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Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/30326160/bradykinin-mechanism-is-the-main-responsible-for-death-by-isolated-asphyxiating-angioedema-in-france
#1
LETTER
Julia Crochet, Marion Lepelley, Nassima Yahiaoui, Céline Vermorel, Jean-Luc Bosson, Pauline Pralong, Marie Thérèse Leccia, Laurence Bouillet
Angioedema (AE) is a sudden localized, subcutaneous or submucosal, swelling due to one of two major possible mechanisms: mast cell induced (MC-AE) or bradykinin mediated (BkAE). MC-AE may be allergic or non-allergic (mast cell degranulation non-specific to the antigen). BkAE may be hereditary, with (C1-INH-HAE) or without C1 inhibitor (C1-INH) deficiency. BkAE may also be acquired with C1-INH deficiency (C1-INH-AAE), complicating some blood diseases, dysimmunities or be iatrogenic, mainly due to angiotensin converting enzyme inhibitors (ACEi)...
October 16, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30312497/role-of-house-dust-mite-derived-extracellular-vesicles-in-a-murine-model-of-airway-inflammation
#2
Jun-Pyo Choi, Seong Gyu Jeon, Yoon-Keun Kim, You Sook Cho
BACKGROUND: House dust mite (HDM) is the major source of indoor allergens that cause airway disease. Recent evidence suggests that Gram-negative/positive bacteria produce nano-sized extracellular vesicles (EVs) containing diverse components, including various immunostimulatory molecules. However, the association between bacteria-derived EVs and development of airway disease is unclear. OBJECTIVE: To identify and isolate HDM derived EVs and to evaluate their effect on the development of airway inflammation...
October 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30311981/breastfeeding-duration-modifies-the-effect-of-smoking-during-pregnancy-on-eczema-from-early-childhood-to-adolescence
#3
Nandini Mukherjee, Thomas R Sutter, S Hasan Arshad, John W Holloway, Hongmei Zhang, Wilfried Karmaus
BACKGROUND: Cigarette smoke contains compounds similar to coal tar, an ancient remedy of eczema. Some studies have reported protective effects of maternal gestational smoking on offspring eczema; however, others have shown no or increased risks. Similarly, studies linking breastfeeding duration and eczema have demonstrated contradictory findings. No study has yet investigated combined effects of these two factors on eczema. OBJECTIVE: Since tobacco compounds can pass to offspring via breast milk, we investigated their combined effects on eczema development from childhood to adolescence...
October 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30307073/rational-targeting-cdc42-restrains-th2-cell-differentiation-and-prevents-allergic-airway-inflammation
#4
Jun-Qi Yang, Khalid W Kalim, Yuan Li, Xin Duan, Phuong Nguyen, Gurjit K Khurana Hershey, John Kroner, Brandy Ruff, Zhang Li, Nathan Salomonis, Mark Rochman, Ting Wen, Yi Zheng, Fukun Guo
BACKGROUND: Asthma is an allergic airway inflammation-driven disease that affects more than 300 million people worldwide. Targeted therapies for asthma are largely lacking. Although asthma symptoms can be prevented from worsening, asthma development can't be prevented. Cdc42 GTPase has been shown to regulate actin cytoskeleton, cell proliferation and survival. OBJECTIVES: To investigate the role and targeting of Cdc42 in Th2 cell differentiation and Th2-mediated allergic airway inflammation...
October 11, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30295352/rho-and-rac-but-not-rock-are-required-for-secretion-of-human-and-mouse-eosinophil-associated-rnases
#5
Revital Shamri, Kristen M Young, Peter F Weller
BACKGROUND: Eosinophil-associated RNases (EARs) are stored preformed in eosinophil cytoplasmic secretory granules and have a key role in eosinophil effector functions in host defense and inflammatory disorders. However, the secretion mechanisms of EARs are poorly understood. OBJECTIVE: Our study aimed to understand the involvement of cytoskeleton machinery in EAR secretion. METHODS: Fresh human and mouse eosinophils were stimulated with CCL11 and the secretion of enzymatically active EARs was detected using an RNAse activity assay...
October 8, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30294841/can-alternative-epitope-mapping-approaches-increase-the-impact-of-b-cell-epitopes-in-food-allergy-diagnostics
#6
A M Ehlers, M A Blankestijn, A C Knulst, M Klinge, H G Otten
In vitro allergy diagnostics are currently based on detection of specific IgE binding on intact allergens or a mixture thereof. This approach has drawbacks as it may yield false negative and/or false positive results. Thus, we review the impact of known B-cell epitopes of food allergens to predict transience or persistence, tolerance or allergy and the severity of an allergic reaction and to examine new epitope mapping strategies meant to improve serum-based allergy diagnostics. Recent epitope mapping approaches have been worthwhile in epitope identification and may increase the specificity of allergy diagnostics by using epitopes predominately recognised by allergic patients in some cases...
October 8, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30288827/staphylococcus-aureus-derived-extracellular-vesicles-induce-monocyte-recruitment-by-activating-human-dermal-microvascular-endothelial-cells-in-vitro
#7
Jihye Kim, Bum-Ho Bin, Eun-Jeong Choi, Hyun Gee Lee, Tae Ryong Lee, Eun-Gyung Cho
BACKGROUND: Atopic dermatitis (AD) represents the most common inflammatory skin disorder in children showing massive infiltration of immune cells. The colonization of AD-afflicted skin by Staphylococcus aureus and S. aureus-derived extracellular vesicles (SEVs) has been associated with AD pathogenesis; however, the molecular mechanism underlying SEV-mediated inflammatory responses remains unclear. OBJECTIVE: We investigated how SEVs can mediate inflammatory responses in AD pathogenesis by examining the effect of SEVs on human dermal microvascular endothelia cells (HDMECs)...
October 4, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30288821/early-life-exposure-to-sibling-modifies-the-relationship-between-cd14-polymorphisms-and-allergic-sensitisation
#8
Melisa Yi Zhi Lau, Shyamali Chandrika Dharmage, John Anthony Burgess, Aung Ko Win, Adrian John Lowe, Caroline Lodge, Jennifer Perret, Jennie Hui, Paul Thomas, Graham Giles, Bruce R Thompson, Michael J Abramson, Eugene Haydn Walters, Melanie Claire Matheson
BACKGROUND: Markers of microbial exposure are thought to be associated with risk of allergic sensitisation, however the associations are inconsistent and may be related to gene-environment interactions. OBJECTIVE: To examine the relationship between polymorphisms in the CD14 gene and allergic sensitisation and whether sibling exposure, as a marker of microbial exposure, modified this relationship. METHODS: We used data from the Tasmanian Longitudinal Health Study and the Melbourne Atopy Cohort Study...
October 4, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30288817/food-induced-fatal-anaphylaxis-from-epidemiological-data-to-general-prevention-strategies
#9
Guillaume Pouessel, Paul J Turner, Margitta Worm, Victòria Cardona, Antoine Deschildre, Etienne Beaudouin, Jean-Marie Renaudin, Pascal Demoly, Luciana K Tanno
BACKGROUND: Anaphylaxis hospitalisations are increasing in many countries, in particular for medication and food triggers in young children. Food-related anaphylaxis remains an uncommon cause of death, but a significant proportion of these are preventable. AIM: To review published epidemiological data relating to food-induced anaphylaxis and potential risk factors of fatal and/or near-fatal anaphylaxis cases, in order to provide strategies to reduce the risk of severe adverse outcomes in food anaphylaxis...
October 4, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30288810/updates-on-the-surface-antigens-of-basophils-cd16-on-basophils-of-patients-with-respiratory-or-insect-venom-allergy-and-the-rejection-of-cd203c-and-cd63-externalization-decoupling-by-bisindolylmaleimides
#10
Petr Heneberg, Kamila Riegerová, Adéla Říhová, Daniela Šimčíková, Petr Kučera
BACKGROUND: CD16 was previously suggested to be a new marker of basophils that is subject to downregulation by FcεRI crosslinking. Certain compounds, including supraoptimal concentrations of the PKC inhibitors, bisindolylmaleimides, decouple the release of granules containing CD203c, CD63 and histamine, and may thus help to identify the mechanisms related to the CD16 externalization. OBJECTIVE: We hypothesized that CD16 is differentially expressed on the surface of basophils in patients with birch pollen or insect venom allergy and is subject to a regulation in response to allergens...
October 4, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30269403/ratios-of-specific-igg-4-over-ige-antibodies-do-not-improve-prediction-of-peanut-allergy-nor-of-its-severity-compared-to-specific-ige-alone
#11
M R Datema, E Eller, A H Zwinderman, L K Poulsen, S AVersteeg, R van Ree, Carsten Bindslev-Jensen
BACKGROUND: IgG(4) antibodies have been suggested to play a protective role in the translation of peanut sensitization into peanut allergy. Whether they have added value as diagnostic read-out has not yet been reported. OBJECTIVE: To evaluate whether (1) peanut specific IgG, IgG4 and/or IgA antibodies are associated with tolerance and/or less severe reactions, and (2) they can improve IgE-based diagnostic tests. METHODS: Sera of 137 patients with challenge-proven peanut allergy and of 25 subjects that tolerated peanut, both with known IgE profiles to peanut extract and five individual peanut allergens, were analyzed for specific IgG and IgG4 ...
September 30, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30267550/the-immunome-of-soybean-allergy-comprehensive-identification-and-characterization-of-epitopes
#12
Karolin Kern, Heide Havenith, Nicolas Delaroque, Paul Rautenberger, Jörg Lehmann, Markus Fischer, Holger Spiegel, Stefan Schillberg, Eva Ehrentreich-Foerster, Stefanie Aurich, Regina Treudler, Michael Szardenings
BACKGROUND: The precise mapping of multiple antibody epitopes recognized by patients' sera allows a more detailed and differentiated understanding of immunologic diseases. It may lead to the development of novel therapies and diagnostic tools. OBJECTIVE: Mapping soybean specific epitopes relevant for soybean allergy patients and persons sensitized to soybean, and analysis of their IgE/IgG binding spectrum. METHODS: Identification of epitopes using sera, applying an optimized peptide-phage display library followed by next-generation sequencing, specially designed in silico data analysis and subsequent peptide microarray analysis...
September 29, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30244525/potential-cofactors-in-accidental-food-allergic-reactions-are-frequently-present-but-may-not-influence-severity-and-occurrence
#13
Astrid Versluis, Harmieke van Os-Medendorp, W Marty Blom, Anouska Michelsen-Huisman, Jacqueline J M Castenmiller, Hubert P J M Noteborn, Geert F Houben, André C Knulst
BACKGROUND: Cofactors, like physical exercise and alcohol intake, might be associated with the severity or occurrence of food allergic reactions. OBJECTIVE: To gain insight into the frequency of presence of potential cofactors in accidental food allergic reactions in adults and to what extent these factors influence the severity and occurrence of allergic reactions.  METHODS: A prospective cohort study was conducted, with a one-year follow-up in adult patients with a physician-diagnosed food allergy...
September 23, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30244522/bronchoscopic-mucosal-cryobiopsies-as-a-method-for-studying-airway-disease
#14
Morten Hvidtfeldt, Alexis Pulga, Morten Hostrup, Caroline Sanden, Michiko Mori, Daisy Bornesund, Klaus Richter Larsen, Jonas S Erjefält, Celeste Porsbjerg
BACKGROUND: Investigating disease mechanisms and treatment responses in obstructive airway diseases with invasive sampling is hampered by the small size and mechanical artefacts that conventional forceps biopsies suffer from. Endoscopic cryobiopsies are larger and more intact and are being increasingly used. However, the technique has not yet been explored for obtaining mucosa biopsies. OBJECTIVE: To investigate differences in size and quality of endobronchial mucosal biopsies obtained with cryotechnique and forceps...
September 23, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30244512/excision-release-of-oxidatively-induced-dna-base-lesions-from-the-lung-genome-by-cat-dander-extract-challenge-stimulates-allergic-airway-inflammation
#15
Koa Hosoki, Pawel Jaruga, Toshiko Itazawa, Leopoldo Aguilera-Aguirre, Erdem Coskun, Tapas K Hazra, Istvan Boldogh, Miral Dizdaroglu, Sanjiv Sur
BACKGROUND: Ragweed pollen extract (RWPE) induces TLR4-NFκB-CXCL-dependent recruitment of ROS-generating neutrophils to the airway and OGG1 DNA glycosylase-dependent excision of oxidatively-induced 8-OH-Gua DNA base lesions from the airway epithelial cell genome. Administration of free 8-OH-Gua base stimulates RWPE-induced allergic lung inflammation. These studies suggest that stimulation of innate receptors and their adaptor by allergenic extracts initiates excision of a set of DNA-base lesions that facilitate innate/allergic lung inflammation...
September 23, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30244507/in-utero-exposure-to-cigarette-smoke-and-effects-across-generations-a-conference-of-animals-on-asthma
#16
B Hammer, C Wagner, A Divac Rankov, S Reuter, S Bartel, M N Hylkema, A Krüger, C Svanes, S Krauss-Etschmann
BACKGROUND: The prevalence of asthma and chronic obstructive pulmonary disease (COPD) has risen markedly over the last decades and is reaching epidemic proportions. However, underlying molecular mechanisms are not fully understood, hampering the urgently needed development of approaches to prevent these diseases. It is well established from epidemiological studies that prenatal exposure to cigarette smoke is one of the main risk factors for aberrant lung function development or reduced fetal growth, but also for the development of asthma and possibly COPD later in life...
September 23, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30230072/enterovirus-infection-during-pregnancy-is-inversely-associated-with-atopic-disease-in-the-offspring
#17
Laura Korhonen, Tapio Seiskari, Jussi Lehtonen, Leena Puustinen, Heljä-Marja Surcel, Anna-Maija Haapala, Onni Niemelä, Suvi M Virtanen, Hanna Honkanen, Mira Karjalainen, Jorma Ilonen, Riitta Veijola, Mikael Knip, Maria Lönnrot, Heikki Hyöty
BACKGROUND: Prenatal environment has been shown to influence child's risk of atopic diseases. Laboratory-confirmed data about the role of maternal infections during pregnancy is scarce. OBJECTIVE: The aim of this study was to determine the associations between serologically-confirmed maternal infections during pregnancy and atopic disease in the offspring. METHODS: This was a nested case-control study within a prospective birth cohort study...
September 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30230060/multidisciplinary-approach-to-the-management-of-adult-eosinophilic-oesophagitis-in-the-united-kingdom
#18
LETTER
Hannah Hunter, Kristina Pupinyte, Terry Wong, Sebastian Zeki, Jason M Dunn, Evelyn Toner, Stephen J Till, Miranda C E Lomer
Dietary intervention is effective for the management of eosinophilic oesophagitis (EoE) in both adults and children [1]. The majority of research has been conducted in Spain or the United States [1], with no studies of dietary intervention published in the United Kingdom. Restrictive elimination diets can be challenging and swallowed topical corticosteroids have also been shown to be an effective treatment in adults This article is protected by copyright. All rights reserved.
September 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30230051/the-house-dust-mite-allergen-der-p-5-binds-lipid-ligands-and-stimulates-airway-epithelial-cells-through-a-tlr2-dependent-pathway
#19
Pinya Pulsawat, Tewarit Songrung, Pattraporn Satitsuksanoa, Maxime Le Mignon, Souad Khemili, Dimitri Gilis, Emmanuel Nony, Malcolm W Kennedy, Alain Jacquet
BACKGROUND: Protein crystallographic studies suggest that the house dust mite (HDM) allergen Der p 5 potentially interacts with hydrophobic ligands. Der p 5, in association with its ligand(s), might therefore trigger innate immune signaling pathways in the airway epithelium and influence the initiation of the HDM-allergic response. OBJECTIVE: We investigated the lipid-binding propensities of recombinant (r)Der p 5 and characterized the signaling pathways triggered by the allergen in airway epithelial cells...
September 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30220097/non-atopic-rhinitis-at-age-6-is-associated-with-subsequent-development-of-asthma
#20
Tara F Carr, Debra A Stern, Marilyn Halonen, Anne L Wright, Fernando D Martinez
BACKGROUND: It has been postulated that the association between allergic rhinitis and asthma is attributable to the progressive clinical expression of respiratory inflammation during childhood. The role of non-allergic rhinitis in early life in relation to subsequent asthma has not been extensively explored. OBJECTIVE: We sought to determine whether rhinitis in early life was associated with risk of asthma development into adulthood, and whether this relationship is independent of allergic sensitization...
September 16, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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