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Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/29451337/eosinophil-derived-exosomes-contribute-to-asthma-remodelling-by-activating-structural-lung-cells
#1
José A Cañas, Beatriz Sastre, José M Rodrigo-Muñoz, Mar Fernández-Nieto, Pilar Barranco, Santiago Quirce, Joaquín Sastre, Victoria Del Pozo
BACKGROUND: Eosinophils, a central factor in asthma pathogenesis, have the ability to secrete exosomes. However, the precise role played by exosomes in the biological processes leading up to asthma has not been fully defined. OBJECTIVE: We hypothesised that exosomes released by eosinophils contribute to asthma pathogenesis by activating structural lung cells. METHODS: Eosinophils from asthmatic patients and healthy volunteers were purified from peripheral blood, and exosomes were isolated from eosinophils of asthmatic and healthy individuals...
February 16, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29442385/is-yoghurt-an-acceptable-alternative-to-raw-milk-for-reducing-eczema-and-allergy-in-infancy
#2
LETTER
Julian Crane, Christine Barthow, Edwin A Mitchell, Thorsten V Stanley, Gordon Purdie, Judy Rowden, Janice Kang, Fiona Hood, Phillipa Barnes, Penny Fitzharris, Robyn Maude, Peter Stone, Rinki Murphy, Kristin Wickens
We have recently completed a randomised controlled trial of maternal supplementation of the probiotic Lactobacillus rhamnosus HN001 (HN001), exploring effects on maternal and infant health. The methodology(1) and the maternal outcomes, gestational diabetes and symptoms of postnatal depression and anxiety have recently been published(2) (3). Briefly, mothers were randomised at 14-16 weeks gestation to receive HN001 (6x 109cfu) or placebo daily during pregnancy and for 6 months postpartum while breast feeding...
February 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29436051/alum-adjuvanted-allergoids-induce-functional-ige-blocking-antibodies
#3
LETTER
M Reithofer, S L Böll, C Kitzmüller, F Horak, M Sotoudeh, B Bohle, B Jahn-Schmid
The only therapy that is able to modulate the cause of IgE-mediated allergy and to attain a long-term effect is allergen-specific immunotherapy (AIT). In conventional subcutaneous AIT, the vaccine consists of an extract from an allergen source that contains major and minor allergens as well as non-allergenic proteins. To reduce IgE-mediated side effects caused by the injection of intact allergens, chemically modified extracts with less IgE-binding activity, named allergoids, have been used for AIT since the 1980's...
February 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29431885/important-and-specific-role-for-basophils-in-acute-allergic-reactions
#4
Peter Korošec, Bernhard F Gibbs, Matija Rijavec PhD, Adnan Custovic, Paul J Turner
IgE-mediated allergic reactions involve the activation of effector cells, predominantly through the high-affinity IgE receptor (FcεRI) on mast cells and basophils. Although the mast cell is considered the major effector cell during acute allergic reactions, more recent studies indicate a potentially important and specific role for basophils and their migration which occurs rapidly upon allergen challenge in humans undergoing anaphylaxis. We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis, and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response...
February 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29431874/short-chain-fatty-acids-induce-tissue-plasminogen-activator-in-airway-epithelial-cells-via-gpr41-43
#5
Yoshimasa Imoto, Atsushi Kato, Tetsuji Takabayashi, Masafumi Sakashita, James E Norton, Lydia A Suh, Roderick G Carter, Ava R Weibman, Kathryn E Hulse, Whitney Stevens, Kathleen E Harris, Anju T Peters, Leslie C Grammer, Bruce K Tan, Kevin Welch, David B Conley, Robert C Kern, Shigeharu Fujieda, Robert P Schleimer
BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous chronic inflammatory disease generally divided based on presence or absence of nasal polyps (NPs). One of the features of NPs is excessive fibrin deposition, which is associated with down regulation of tissue plasminogen activator (t-PA) in NPs. As t-PA is expressed in epithelial cells, and epithelium is readily accessible to topical therapies, identifying compounds that can mediate the induction of t-PA would be a potential new strategy for the treatment of NPs...
February 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29423947/the-effects-of-a-ccr3-inhibitor-axp1275-on-allergen-induced-airway-responses-in-adults-with-mild-to-moderate-atopic-asthma
#6
G M Gauvreau, J M FitzGerald, L P Boulet, R M Watson, L Hui, H Villineuve, T X Scime, A R Schlatman, C Obminski, J Kum, S Boehme, T W Ly, K B Bacon, P M O'Byrne
BACKGROUND: CCR3 is the cognate receptor for major human eosinophil chemoattractants from the eotaxin family of proteins that are elevated in asthma and correlate with disease severity. OBJECTIVE: This proof-of-mechanism study examined the effect of AXP1275, an oral, small-molecule inhibitor of CCR3, on airway responses to inhaled allergen challenge. METHODS: Twenty-one subjects with mild atopic asthma and documented early and late asthmatic responses to an inhaled aeroallergen completed a randomized double-blind crossover study to compare early and late allergen-induced asthmatic responses, methacholine PC20 , blood and sputum eosinophils, and exhaled nitric oxide after 2 weeks of treatment with once-daily doses of AXP1275 (50 mg) or placebo...
February 9, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29412488/influence-of-peanut-matrix-on-stability-of-allergens-in-gastric-simulated-digesta-2s-albumins-are-main-contributors-to-the-ige-reactivity-of-short-digestion-resistant-peptides
#7
Ivana Prodic, Dragana Stanic-Vucinic, Danijela Apostolovic, Jelena Mihailovic, Milica Radibratovic, Jelena Radosavljevic, Lidija Burazer, Milos Milcic, Katarina Smiljanic, Marianne van Hage, Tanja Cirkovic Velickovic
BACKGROUND: Most food allergens sensitizing via the gastrointestinal tract are stable proteins that are resistant to pepsin digestion, in particular major peanut allergens, Ara h 2 and Ara h 6. Survival of their large fragments is essential for sensitizing capacity. However, the immunoreactive proteins/peptides to which the immune system of the gastrointestinal tract is exposed during digestion of peanut proteins is unknown. Particularly, the IgE-reactivity of short digestion-resistant peptides (<10 kDa) released by gastric digestion under standardized and physiologically relevant in vitro conditions has not been investigated...
February 7, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29412485/advancing-the-management-of-obstructive-airways-diseases-through-translational-research
#8
Celeste Porsbjerg, Asger Sverrild, Katherine J Baines, Andrew Searles, Steven Maltby, Paul S Foster, Chris Brightling, Peter G Gibson
Obstructive airways diseases (OAD) represent a huge burden of illness worldwide, and in spite of the development of effective therapies, significant morbidity and mortality related to asthma and COPD still remains. Over the past decade, our understanding of OAD has improved vastly, and novel treatments have evolved. This evolution is the result of successful translational research, which has connected clinical presentations of OAD and underlying disease mechanisms, thereby enabling the development of targeted treatments...
February 7, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29405462/environmental-peanut-exposure-increases-the-risk-of-peanut-sensitization-in-high-risk-children
#9
Helen A Brough, Inger Kull, Kerry Richards, Eva Hallner, Cilla Söderhäll, Abdel Douiri, Martin Penagos, Erik Melén, Anna Bergström, Victor Turcanu, Magnus Wickman, Gideon Lack
BACKGROUND: High household peanut consumption is associated with the development of peanut allergy, especially when peanut allergic cases are compared against atopic controls; thus environmental peanut exposure (EPE) may be a risk factor for peanut sensitization and allergy. In this study we explored the relationship between EPE and school-age peanut sensitization in a population based cohort. METHODS: Maternal bed-dust was collected postnatally and EPE was quantified using a polyclonal peanut ELISA...
February 6, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29383792/repeated-vaccination-with-tetanus-toxoid-of-plasma-donors-with-pre-existing-specific-ige-transiently-elevates-tetanus-specific-ige-but-does-not-induce-allergic-symptoms
#10
LETTER
Peter-Paul A Unger, Mateusz Makuch, Marja Aalbers, Ninotska I L Derksen, Anja Ten Brinke, Rob C Aalberse, Theo Rispens, S Marieke van Ham
IgE responses against allergens have acquired much attention due to their pathogenic nature as mediators of allergic reactions. In contrast, IgE responses against vaccines like Diphtheria-Tetanus-Pertussis (DTP) and the potential persistence of IgE production have received relatively little attention, presumably because of the low prevalence of allergic symptoms. In general, common early sensitivity reactions against vaccines, including tetanus toxoid, consist of mild local reactions and are not contraindicative of future vaccinations (1, 2)...
January 31, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29383785/neutrophilia-gelatinase-release-and-microvascular-leakage-induced-by-human-mast-cell-tryptase-in-a-mouse-model-lack-of-a-role-of-protease-activated-receptor-2-par2
#11
Mogibelrahman M S Khedr, Ahmed M Abdelmotelb, Sylvia L F Pender, Xiaoying Zhou, Andrew F Walls
BACKGROUND: Tryptase, the most abundant protease of the human mast cell, has been implicated as a key mediator of allergic inflammation that acts through activation of PAR2. OBJECTIVES: To investigate the contribution of PAR2 in the pro-inflammatory actions mediated by tryptase in a mice model. METHODS: We have injected recombinant human βII-tryptase into the peritoneum of PAR2-deficient and wild-type C57BL/6 mice. After 6, 12 and 24 hours mice were euthanized, peritoneal lavage performed and inflammatory changes investigated...
January 31, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29383782/step-down-of-inhaled-corticosteroids-in-non-eosinophilic-asthma-a-prospective-trial-in-real-life
#12
Sophie Demarche, Florence Schleich, Monique Henket, Virginie Paulus, Renaud Louis, Thierry Van Hees
BACKGROUND: While non-eosinophilic asthmatics are usually considered poorly responsive to inhaled corticosteroids (ICS), studies assessing a step-down of ICS in this specific population are currently lacking. OBJECTIVES: To assess the proportion of non-eosinophilic asthmatics in whom ICS may be withdrawn without any clinical degradation and to determine the predictive markers of a failure to stop treatment with ICS. METHODS: This prospective study was completed by 36 non-eosinophilic asthmatics, defined by sputum eosinophils <3% and blood eosinophils <400/μL...
January 31, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29383778/obese-asthmatics-are-characterised-by-altered-adipose-tissue-macrophage-activation
#13
Hashim A Periyalil, Lisa G Wood, Timothy A Wright, Constantin Karihaloo, Malcolm R Starkey, April S Miu, Katherine J Baines, Philip M Hansbro, Peter G Gibson
Adipose tissue-derived inflammation is linked to obesity-related co-morbidities. This study aimed to quantify and immuno-phenotype adipose tissue macrophages (ATMs) from obese asthmatics and obese non-asthmatics, and to examine associations between adipose tissue, systemic and airway inflammation. Visceral (VAT) and sub-cutaneous (SAT) adipose tissue were collected from obese adults undergoing bariatric surgery and processed to obtain the stromovascular fraction. Pro- (M1) and anti-inflammatory (M2) macrophages were quantified by flow cytometry...
January 31, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29383776/temperature-controlled-laminar-airflow-tla-device-in-the-treatment-of-children-with-severe-atopic-eczema-open-label-proof-of-concept-study
#14
Claudia Gore, Robin B Gore, Sara Fontanella, Sadia Haider, Adnan Custovic
BACKGROUND: Children with severe, persistent atopic eczema (AE) have limited treatment options, often requiring systemic immunosuppression. OBJECTIVE: To evaluate the effect of the temperature-controlled laminar airflow (TLA) treatment in children/adolescents with severe AE. METHODS: We recruited 15 children aged 2-16 years with longstanding, severe AE and sensitization to ≥1 perennial inhalant allergen. Run-in period of 6-10 weeks (3 visits), was followed by 12-month treatment with overnight TLA (Airsonett® , Sweden)...
January 31, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29381238/16s-rrna-profiling-of-the-dermatophagoides-farinae-core-microbiome-enterococcus-and-bartonella
#15
LETTER
Ju Yeong Kim, Myunghee Yi, Younjee Hwang, Jin Young Lee, In-Yong Lee, Dongeun Yong, Tai-Soon Yong
Characterization of the house dust mite (HDM; Dermatophagoides farinae) microbiome is important because it may exert immunomodulatory effects on the pathogenesis of allergic diseases, owing to its ability to generate microbe-associated molecules such as lipopolysaccharides and lipoteichoic acid.[1] In a recent study, whole-genome shotgun sequencing of D. farinae revealed that Enterobacter were the most abundant bacteria[2], while another study using 16S rRNA cloning reported that Bartonella was the most abundant bacterial taxon...
January 30, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29377469/component-resolved-diagnostics-demonstrates-that-most-peanut-allergic-individuals-could-potentially-introduce-tree-nuts-to-their-diet
#16
Riikka Uotila, Anna Kaarina Kukkonen, W Marty Blom, Ben Remington, Joost Westerhout, Anna Susanna Pelkonen, Mika Juhani Mäkelä
BACKGROUND: Nut allergy varies from pollen cross-allergy, to primary severe allergy with life-threatening symptoms. The screening of IgE antibodies to a wide spectrum of allergens, including species-specific and cross-reactive allergens, is made possible via microarray analysis. OBJECTIVE: We sought to study the association of variable IgE sensitization profiles to clinical response in peanut-challenged children and adolescents in a birch-endemic region. In addition, we studied the avoidance of tree nuts and species-specific sensitizations...
January 29, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29377450/absence-of-serum-ige-antibodies-indicates-non-type-2-disease-in-young-asthmatics
#17
N Tsolakis, A Malinovschi, L Nordvall, C Janson, M P Borres, K Alving
BACKGROUND: Atopic asthma is associated with elevated type-2 biomarkers such as fraction of exhaled nitric oxide (FeNO) and blood eosinophil (B-Eos) count. However, increased type-2 markers have also been reported in traditionally-defined non-atopic asthma. OBJECTIVE: To determine a clinically useful level of IgE sensitisation for ruling out type-2 asthma. METHODS: Asthmatics (N = 408; age 10-35 years) were analysed using the multi-allergen tests Phadiatop and fx5 (ImmunoCAP)...
January 29, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29369458/clinical-reactivity-of-celery-cultivars-in-allergic-patients-role-of-api-g-1
#18
S Dölle, S Welter, E Ruppel, K Lehmann, D Schwarz, E Jensen-Jarolim, P Zieglmayer, P Franken, M Worm
BACKGROUND: Celery (Apium graveolens L.) is a vegetable consumed worldwide. Celery stalks and celeriac roots are often ingredients in convenient food products like spice blends and soups. OBJECTIVE: In this study, we examined the allergenicity of distinct celeriac cultivars. METHODS: Sixteen celery allergic patients were identified using a double-blind, placebo-controlled food challenge (DBPCFC). Ten different celeriac cultivars were used for skin prick testing in the patients...
January 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29369455/development-and-validation-of-the-cholinergic-urticaria-quality-of-life-questionnaire-cholu-qol
#19
J Ruft, A Asady, P Staubach, T Casale, G Sussmann, T Zuberbier, M Maurer, K Weller, S Altrichter
BACKGROUND: Cholinergic urticaria (CholU), a common form of chronic inducible urticaria, is characterized by itchy wheals that occur in response to physical exercise or passive warming. CholU patients frequently exhibit a high burden of disease. As of yet, no specific instrument is available to assess their disease-related quality of life (QoL) impairment. OBJECTIVE: The aim of this study was to develop and validate the first disease specific QoL instrument for CholU patients, the Cholinergic Urticaria Quality of Life Questionnaire (CholU-QoL)...
January 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29368358/birth-order-and-pediatric-allergic-disease-a-nationwide-longitudinal-survey
#20
Tomonobu Kikkawa, Takashi Yorifuji, Yosuke Fujii, Masato Yashiro, Ayumi Okada, Masanori Ikeda, Hiroyuki Doi, Hirokazu Tsukahara
BACKGROUND: Environmental factors seem to be related to the incidence of allergic disease. Children with a later birth order are often exposed to environments where pathogens and endotoxins can be found, and thus have a higher risk of developing infectious diseases. Therefore, birth order is regarded as an indicator that reflects postnatal environment. However, longitudinal studies are limited on this subject. This study sought to elucidate the relationships between birth order and allergic disease...
January 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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