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Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/28710902/a-brief-psychological-intervention-for-mothers-of-children-with-food-allergy-can-change-risk-perception-and-reduce-anxiety-outcomes-of-a-randomised-controlled-trial
#1
Robert J Boyle, Thisanayagam Umasunthar, Jared G Smith, Heather Hanna, Annabella Procktor, Katherine Phillips, Camila Pinto, Claudia Gore, Helen E Cox, John O Warner, Bea Vickers, Matthew Hodes
BACKGROUND: Mothers of children with food allergy have increased anxiety, which may be influenced by healthcare professionals' communication of risk. OBJECTIVE: To evaluate a brief psychological intervention for reducing anxiety in mothers of children with food allergy. METHODS: Two hundred mothers of children with food allergy were recruited from allergy clinics. A computer-generated randomization list was used to allocate participants to a single-session Cognitive Behavioural Therapy intervention including a risk communication module, or standard care...
July 15, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28710890/food-allergy-phenotypes-the-key-to-personalized-therapy
#2
Antoine Deschildre, Stéphanie Lejeune, Mélanie Cap, Sophie Flammarion, Line Jouannic, Flore Amat, Jocelyne Just
Food allergies (FAs) are of increasing public health concern and are characterized by a large spectrum of diseases. Their diversity is well known for immunologic pathways (IgE, non-IgE mediated FAs), and natural history. Many other factors and patient characteristics are involved including type of food, exposure route, allergic comorbidities, gender, racial and ethnic backgrounds, co-factors and health conditions. Food allergen components and sensitization profiles are also involved in FA phenotypes. A new approach to chronic disorders based on the identification of phenotypes through extensive knowledge of all the complex components is also applicable to FAs and could lead towards integrative care management...
July 15, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28703932/biomarkers-in-allergic-asthma-which-matrix-should-we-use
#3
LETTER
Mauro Maniscalco, Andrea Motta
We have read with great interest the review article by Villaseñor et al. [1] on metabolomics strategies for the identification of novel biomarkers associated with specific phenotypes of allergic asthma. The paper also suggests the usefulness of specific biological matrices in the metabolomics approach to respiratory pathologies, indicating preferentially bronchoalveolar lavage fluid (BALF), lung biopsy or sputum for exploratory studies on molecular mechanism of a respiratory disease, and plasma or urine for detecting diagnostic or prognostic biomarkers...
July 13, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28696503/dose-response-relationship-of-a-new-timothy-grass-pollen-allergoid-in-comparison-to-a-6-grass-pollen-allergoid
#4
O Pfaar, J M Hohlfeld, B Al-Kadah, B Hauswald, B Homey, N Hunzelmann, S Schliemann, P Velling, M Worm, L Klimek
BACKGROUND: Subcutaneous allergen immunotherapy with grass pollen allergoids has been proven to be effective and safe in the treatment of patients with allergic rhinoconjunctivitis. Based on the extensive cross-reactivity among Pooideae species, it has been suggested that grass pollen extracts could be prepared from a single species, rather than from a multiple species mixture. OBJECTIVE: To find the optimal dose of a Phleum pratense allergoid preparation and compare its efficacy and safety to a 6-grass pollen allergoid preparation...
July 11, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28695715/patient-reported-signs-of-dampness-at-home-may-be-a-risk-factor-for-chronic-rhinosinusitis-a-cross-sectional-study
#5
Caroline Ahlroth Pind, María Gunnbjörnsdottír, Anders Bjerg, Bengt Järvholm, Bo Lundbäck, Andrei Malinovschi, Roelinde Middelveld, Johan Nilsson Sommar, Dan Norbäck, Christer Janson
BACKGROUND: An association between dampness at home and respiratory conditions has been convincingly demonstrated in children. Fewer studies have been performed in adults and data are lacking for chronic rhinosinusitis (CRS). With a prevalence of 10.9% in Europe, CRS imposes a significant burden on quality of life, as well as economy. OBJECTIVE: Our aim was to study CRS and other respiratory conditions in relation to dampness at home in a representative sample of adults...
July 11, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28685970/invariant-natural-killer-cells-change-after-an-oral-allergy-desensitization-protocol-for-cow-s-milk
#6
Antonella Cianferoni, Rushani Saltzman, Francesca Saretta, Simona Barni, Emily Dudek, Mary Kelleher, Jonathan M Spergel
BACKGROUND: Cow milk (CM) allergy (CMA) affects up to 3% of the pediatric population and recent data suggest that only about 50% will outgrow by age 8. Oral immunotherapy (OIT) is a type of immune-modulating treatment that is able to induce desensitization to food allergens, to increase tolerance threshold, to reduce the risk of anaphylaxis, and to improve the patient's quality of life. The examination of the immunological changes observed during the establishment of food allergy (FA) desensitization in FA patients is a window into the pathogenesis of food allergy and food tolerance development...
July 7, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28681506/safety-and-pharmacodynamics-of-intranasal-gsk2245035-a-tlr7-agonist-for-allergic-rhinitis-a-randomized-trial
#7
Anne K Ellis, Daphne C Tsitoura, Diana Quint, William Powley, Laurie A Lee
BACKGROUND: Toll-like receptor 7 (TLR7) stimulation in the airways may reduce responses to aeroallergens by induction of type 1 interferons (IFNs). GSK2245035 is a novel selective TLR7 agonist in pharmaceutical development. OBJECTIVE: Assessment of safety, pharmacodynamics and nasal allergic reactivity following repeated weekly intranasal (i.n.) GSK2245035. METHODS: This randomized, double-blind, placebo-controlled study (TL7116958) was conducted over two pollen seasons (2013-2014) and follow-up study (204509) conducted one year later...
July 5, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28665552/comorbidities-in-adults-with-asthma-population-based-cross-sectional-analysis-of-1-4-million-adults-in-scotland
#8
Christopher J Weatherburn, Bruce Guthrie, Stewart W Mercer, Daniel R Morales
BACKGROUND: Comorbidity in people with asthma can significantly increase asthma morbidity and lower adherence to asthma guidelines. OBJECTIVE: The objective of this study was to comprehensively measure the prevalence of physical and mental health comorbidities in adults with asthma using a large nationally representative population. METHODS: Cross-sectional analysis of routine primary care electronic medical records for 1,424,378 adults in the UK, examining the prevalence of 39 comorbidities in people with and without asthma, before and after adjustment for age, sex, social deprivation and smoking status using logistic regression...
June 30, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28665534/bronchoprotective-tolerance-with-indacaterol-is-not-modified-by-concomitant-tiotropium-in-persistent-asthma
#9
Sunny Jabbal, Arvind Manoharan, Brian Lipworth
BACKGROUND: Tiotropium is a long acting antimuscarinic (LAMA), licenced as triple therapy with inhaled corticosteroid and long acting beta-agonist (ICS/LABA). There may be a synergistic benefit between LAMA and LABA as a consequence of receptor cross-talk, which in turn could modify beta-2 receptor down-regulation and associated tolerance induced by LABA. OBJECTIVE: We hypothesise this mechanism may result in a reduction of airway hyperresponsiveness (AHR) when using triple therapy...
June 30, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28658564/a-clustering-approach-to-identify-and-characterize-the-asthma-and-chronic-obstructive-pulmonary-disease-overlap-phenotype
#10
Keita Hirai, Toshihiro Shirai, Masayuki Suzuki, Taisuke Akamatsu, Takahito Suzuki, Ichiro Hayashi, Akito Yamamoto, Takefumi Akita, Satoru Morita, Kazuhiro Asada, Daiki Tsuji, Kazuyuki Inoue, Kunihiko Itoh
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases. The phenotypes that have clinical features of both asthma and COPD are still incompletely understood. OBJECTIVE: To clarify the best discriminators of the asthma-COPD overlap phenotype from asthma and COPD subgroups using a clustering approach. METHODS: This study assessed pathophysiological parameters, including mRNA expression levels of T helper cell-related transcription factors, namely, TBX21 (Th1), GATA3 (Th2), RORC (Th17), and FOXP3 (Treg), in peripheral blood mononuclear cells in asthma patients (n = 152) and in COPD patients (n = 50)...
June 28, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28639292/answer-to-biomarkers-in-allergic-asthma-which-matrix-should-we-use
#11
LETTER
Alma Villaseñor, Domenico Rosace, David Obeso, Marina Pérez-Gordo, Tomás Chivato, Coral Barbas, Domingo Barber, María M Escribese
We appreciate comments from Dr. M. Maniscalco and A. Motta on our review article [1]. The comments made on the matter about which biological matrix(ces) should be used in the quest of biomarkers in allergic asthma are well accepted. However, we would like to open the discussion about the topics exposed by the authors. Definitely, asthma is a very complex disease which presents heterogeneous clinical symptoms and multiple causes. Presenting diverse sub-phenotypes, to date there is not enough information to characterize them in the clinical setting [2, 3]...
June 22, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28626990/exhaled-breath-profiles-in-the-monitoring-of-loss-of-control-and-clinical-recovery-in-asthma
#12
P Brinkman, M A van de Pol, M G Gerritsen, L D Bos, T Dekker, B S Smids, A Sinha, C J Majoor, M M Sneeboer, H H Knobel, T J Vink, F H de Jongh, R Lutter, P J Sterk, N Fens
BACKGROUND: Asthma is a chronic inflammatory airway disease, associated with episodes of exacerbations. Therapy with inhaled corticosteroids (ICS) targets airway inflammation, which aims to maintain and restore asthma control. Clinical features are only modestly associated with airways inflammation. Therefore, we hypothesized that exhaled volatile metabolites identify longitudinal changes between clinically stable episodes and loss of asthma control. OBJECTIVES: To determine whether exhaled volatile organic compounds (VOCs) as measured by gas-chromatography/mass-spectrometry (GC/MS) and electronic nose (eNose) technology discriminate between clinically stable and unstable episodes of asthma...
June 19, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28618148/mechanisms-underlying-induction-of-allergic-sensitization-by-pru-p-3
#13
L Tordesillas, N Cubells-Baeza, C Gómez-Casado, C Berin, V Esteban, W Barcik, L O'Mahony, C Ramirez, L F Pacios, M Garrido-Arandia, A Díaz-Perales
BACKGROUND: Recently, the nature of the lipid-ligand of Pru p 3, one of the most common plant food allergens in southern Europe, has been identified as a derivative of the alkaloid camptothecin bound to phytosphingosine. However, the origin of its immunological activity is still unknown. OBJECTIVE: We sought to evaluate the role of the Pru p 3 lipid-ligand in the immunogenic activity of Pru p 3. METHODS: In vitro cultures of different cell types (monocyte-derived dendritic cells [moDCs], PBMCs [peripheral blood mononuclear cells] and epithelial and iNKT-hybridoma cell lines) have been used to determine the immunological capacity of the ligand, by measuring cell proliferation, maturation markers and cytokine production...
June 15, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28618090/roadmap-for-the-clinical-application-of-the-basophil-activation-test-in-food-allergy
#14
Alexandra F Santos, Wayne G Shreffler
The diagnosis of IgE-mediated food allergy based solely on the clinical history and the documentation of specific IgE to whole allergen extract or single allergens is often ambiguous, requiring oral food challenges (OFC), with the attendant risk and inconvenience to the patient, to confirm the diagnosis of food allergy. This is a considerable proportion of patients assessed in Allergy clinics. The basophil activation test (BAT) has emerged as having superior specificity and comparable sensitivity to diagnose food allergy, when compared with skin prick test and specific IgE...
June 15, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28608416/increased-prevalence-of-allergic-asthma-from-1996-to-2006-and-further-to-2016-results-from-three-population-surveys
#15
Helena Backman, Petri Räisänen, Linnea Hedman, Caroline Stridsman, Martin Andersson, Anne Lindberg, Bo Lundbäck, Eva Rönmark
BACKGROUND: During the latter half of the 20(th) century the prevalence of asthma and many other allergic diseases has increased. Information on asthma prevalence trends after 2010, especially regarding studies separating allergic asthma from non-allergic asthma is lacking. OBJECTIVE: The aim was to estimate prevalence trends of current asthma, both allergic and non-allergic, from 1996 to 2016. METHODS: Three cross-sectional samples from the same area of Sweden, 20-69 years, participated in surveys with the same questionnaire in 1996 (n=7104 participants, 85% response rate), 2006 (n=6165, 77%) and 2016 (n=5466, 53%), respectively...
June 13, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28599075/increased-risk-of-asthma-in-overweight-children-born-large-for-gestational-age
#16
Leonardo A Pinto, Stefano Guerra, Josep M Anto, Dirkje Postma, Gerard H Koppelman, Johan C de Jongste, Ulrike Gehring, Henriette A Smit, Alet Wijga
BACKGROUND: Being born large for gestational age (LGA) is a marker of increased growth velocity in fetal life and a risk factor for childhood overweight. Both being born LGA and childhood overweight may influence the development of asthma, although the role of overweight in the association between LGA and childhood asthma is unclear. Importantly, recent studies have suggested that the association between overweight and asthma may be related to non-allergic pathways. If this also applies to the association between LGA and asthma, the association between being born LGA and asthma may be different for atopic and non-atopic children...
June 9, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28547822/in-memory-and-celebration-dr-james-j-lee
#17
LETTER
Helene F Rosenberg, Allison D Fryer, Ariel Munitz, Bruce S Bochner, David B Jacoby, Francesca Levi-Schaffer, Gerald J Gleich, Glenn T Furuta, Marc E Rothenberg, Paige Lacy, Patricia C Fulkerson, Simon P Hogan, Steven J Ackerman, Paul S Foster
We come together to mourn the untimely passing of Dr. James (Jamie) J. Lee, Professor of Biochemistry and Molecular Biology in the Division of Pulmonary Medicine at Mayo Clinic Arizona. A leading scientist, talented teacher, prominent role model, and Eosino-philosopher-in-Chief, Jamie's many enthusiasms and joy for science inspired us all. Together with his wife and research partner, Dr. Nancy Lee, Jamie's academic career was dedicated to improving our understanding of eosinophils and to exploring their contributions to chronic respiratory diseases and cancer...
May 26, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28543872/pai-1-gain-of-function-genotype-factors-increasing-pai-1-levels-and-airway-obstruction-the-gala-ii-cohort
#18
Michael G Sherenian, Seong H Cho, Albert Levin, Jin-Young Min, Sam S Oh, Donglei Hu, Joshua Galanter, Saunak Sen, Scott Huntsman, Celeste Eng, Jose R Rodriguez-Santana, Denise Serebrisky, Pedro C Avila, Ravi Kalhan, Lewis J Smith, Luisa N Borrell, Max A Seibold, L Keoki Williams, Esteban G Burchard, Rajesh Kumar
BACKGROUND: PAI-1 gain of function variants promote airway fibrosis, and are associated with asthma and with worse lung function in subjects with asthma. OBJECTIVE: We sought to determine if the association of a gain-of-function polymorphism in Plasminogen Activator Inhibitor -1 (PAI-1) with airway obstruction is modified by asthma status, and whether any genotype effect persists after accounting for common exposures that increase PAI-1 level. METHODS: We studied 2070 Latino children (8-21y) with genotypic and pulmonary function data from the GALA II cohort...
May 24, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28502108/expression-of-the-filaggrin-gene-in-umbilical-cord-blood-predicts-eczema-risk-in-infancy-a-birth-cohort-study
#19
Ali H Ziyab, Susan Ewart, Gabrielle A Lockett, Hongmei Zhang, Hasan Arshad, John W Holloway, Wilfried Karmaus
BACKGROUND: Filaggrin gene (FLG) expression, particularly in the skin, has been linked to the development of the skin barrier and is associated with eczema risk. However, knowledge as to whether FLG expression in umbilical cord blood (UCB) is associated with eczema development and prediction is lacking. OBJECTIVE: This study sought to assess whether FLG expression in UCB associates with and predicts the development of eczema in infancy. METHODS: Infants enrolled in a birth cohort study (n = 94) were assessed for eczema at ages 3-, 6-, and 12-months...
May 14, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28493312/minor-allergen-patterns-in-birch-pollen-allergen-products-a-question-of-pollen
#20
J Zimmer, S Döring, D Strecker, J H Trösemeier, K M Hanschmann, F Führer, S Vieths, S Kaul
BACKGROUND: Contrary to the scientific differentiation between major and minor allergens, the regulatory framework controlling allergen products in the EU distinguishes relevant and non-relevant allergens. Given the lack of knowledge on their clinical relevance, minor allergens are usually not controlled by allergen product specifications. Especially in birch pollen (BP) allergen products, minor allergens are commonly disregarded. OBJECTIVES: To quantify three minor allergens in BP allergen products from different manufacturers and to assess the influence of the utilized BP on minor allergen patterns...
May 10, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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