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Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/29908086/innate-immune-response-reflects-disease-activity-in-eosinophilic-granulomatosis-with-polyangiitis
#1
Naomi Tsurikisawa, Chiyako Oshikata, Maiko Watanabe, Takahiro Tsuburai, Takeshi Kaneko, Hiroshi Saito
BACKGROUND: Eosinophilic granulomatosis with polyangiitis (EGPA) is a disease characterized by allergic granulomatosis, necrotizing vasculitis, and peripheral blood eosinophilia. Interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and type-2 innate lymphoid cells (ILC2) are involved in the innate and type-2 immune responses in EGPA. However, the relationships among these molecules and the mechanisms underlying the development of EGPA remain unknown. OBJECTIVE: We investigated the relationships among peripheral blood eosinophil count, serum IL-33 and TSLP concentration, and peripheral blood ILC2 count in patients with EGPA, chronic eosinophilic pneumonia (CEP), or bronchial asthma (BA)...
June 16, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29908083/greater-severity-of-peanut-challenge-reactions-using-a-high-fat-versus-low-fat-matrix-vehicle
#2
LETTER
M Eleonore Pettersson, Gerard H Koppelman, Afke M M Schins, C Doriene van Ginkel, Bertine M J Flokstra-de Blok, Boudewijn J Kollen, Anthony E J Dubois
Food allergy is a potentially life-threatening disease with a detrimental effect on the quality of life of caregivers and children.(1) Although many different types of food have been identified as potential elicitors of allergic reactions, only a small number of these foods cause the majority of reactions.(2) Food consists of a complex mixture of nutrient and non-nutrient components and their molecular interactions, which are known as the food matrix. Individual matrix components, or the matrix as a whole, may interact with a food allergen and may influence the clinical response to that allergen...
June 16, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29905025/on-the-reliability-of-the-cd123-endowed-basophil-activation-test-bat-and-its-application-in-food-allergy
#3
LETTER
Salvatore Chirumbolo, Geir Bjørklund, Antonio Vella
the recent paper by Appel et al., evaluated the use of the basophil activaion test (BAT) in sesame allergy and concluded that BAT should be preferentially used in association with high protein sesame extract-skin prick test (HSPE-SPT) for the diagnosis of sesame food allergy, so preventing any ethical issue regarding the possble risk associated with oral food challenge (OFC)1 . The authors used a non commercial BAT approach endowed with the CD123pos /HLADRneg phenotyping protocol and using CD63 and/or CD203c as activation markers2,3 ...
June 15, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29904978/nasal-cytology-methodology-with-application-to-clinical-practice-and-research
#4
Enrico Heffler, Massimo Landi, Cristiano Caruso, Silvia Fichera, Federica Gani, Giuseppe Guida, Maria Teresa Liuzzo, Maria Provvidenza Pistorio, Stefano Pizzimenti, Anna Maria Riccio, Veronica Seccia, Matteo Ferrando, Luca Malvezzi, Giovanni Passalacqua, Matteo Gelardi
Nasal cytology is an easy, cheap, non-invasive and point-of-care method to assess nasal inflammation and disease-specific cellular features. By means of nasal cytology it is possible to distinguish between different inflammatory patterns that are typically associated with specific diseases (i.e.: allergic and non allergic rhinitis). Its use is particularly relevant when other clinical information, such as signs, symptoms, time-course and allergic sensitizations, are not enough to recognize which of the different rhinitis phenotypes is involved; for example, it is only by means of nasal cytology that it is possible to distinguish, among the non allergic rhinitis, those characterized by eosinophilic (NARES), mastcellular (NARMA), mixed eosinophilic-mastcellular (NARESMA) or neutrophilic (NARNE) inflammation...
June 15, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29904971/a-subset-of-walnut-allergic-adults-is-sensitized-to-walnut-11s-globulin-jug-r-4
#5
Mark A Blankestijn, Constance F den Hartog Jager, W Marty Blom, Henny G Otten, G Aard H de Jong, Marco Gaspari, Geert F Houben, André C Knulst, Kitty C M Verhoeckx
BACKGROUND: The role of sensitization to commercially available allergens of English walnut (Juglans regia) Jug r 1, 2 and 3 in walnut allergy has been previously investigated in walnut allergic adults and was unable to explain allcases of walnut allergy. OBJECTIVES: Identify recognized walnut allergens, other than the ones previously investigated (Jug r 1-3), in walnut allergic adults and determine the sensitization frequency and diagnostic value. METHODS: Three different in-house walnut extracts were prepared and analysed on SDS-PAGE blots to identify allergenic walnut proteins...
June 15, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29900607/local-allergic-rhinitis-implications-for-management
#6
Paloma Campo, Ibon Eguiluz-Gracia, Gador Bogas, María Salas, Carmen Plaza Serón, Natalia Pérez, C Mayorga, M J Torres, Mohammed Shamji, Carmen Rondon
A significant proportion of rhinitis patients without systemic IgE-sensitization tested by skin prick test and serum allergen-specific IgE (sIgE) display nasal reactivity upon nasal allergen provocation test (NAPT). This disease phenotype has been termed local allergic rhinitis (LAR). LAR is an underdiagnosed entity affecting children and adults from different parts of the world, with moderate-to-severe symptoms, impairment of quality of life and rapid progression to symptom worsening. LAR is a stable phenotype and not merely an initial state of AR...
June 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29900603/the-enigmatic-role-of-the-neutrophil-in-asthma-friend-foe-or-indifferent
#7
Robert J Snelgrove, Dhiren F Patel, Tulsi Patel, Clare M Lloyd
Whilst severe asthma has classically been categorised as a predominantly Th2 driven pathology, there has in recent years been a paradigm shift with the realisation that it is a heterogeneous disease that may manifest with quite disparate underlying inflammatory and remodelling profiles. A subset of asthmatics, particularly those with a severe, corticosteroid refractory disease, present with a prominent neutrophilic component. Given the potential of neutrophils to impart extensive tissue damage and promote inflammation, it has been anticipated that these cells are closely implicated in the underlying pathophysiology of severe asthma...
June 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29900599/exploring-what-motivates-and-sustains-support-group-engagement-amongst-young-people-with-allergies-a-qualitative-study
#8
Christina J Jones, Lauren A Sommereux, Helen E Smith
BACKGROUND: Positive self-care behaviours are more likely in young people who engage with allergy support groups, but reasons for this association are not well understood. OBJECTIVES: This study explored how and why young people engage with allergy support groups to identify what activities and resources are beneficial. METHODS: In-depth, semi-structured interviews were conducted with young people aged 12-21 years who reported engaging with allergy support groups (in person or on-line)...
June 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29900602/nlrp3-inflammasome-a-likely-target-for-the-treatment-of-allergic-diseases
#9
Yichen Xiao, Wenna Xu, Wenru Su
Allergic diseases, such as asthma, rhinitis, dermatitis, conjunctivitis, and anaphylaxis, have recently become a global public health concern. According to previous studies, the NLRP3 inflammasome is a multi-protein complex known to be associated with many inflammatory conditions. In response to allergens or allergen/damage-associated molecular signals, NLRP3 changes its conformation to allow the assembly of the NLRP3 inflammasome complex and activates caspase-1, which is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines IL-1β and IL-18...
June 13, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29870077/diagnosis-of-concomitant-inducible-laryngeal-obstruction-and-asthma
#10
Joy W Lee, Tunn Ren Tay, Paul Paddle, Amanda L Richards, Lisa Pointon, Miriam Voortman, Michael J Abramson, Ryan Hoy, Mark Hew
BACKGROUND: Inducible laryngeal obstruction, an induced, inappropriate narrowing of the larynx, leading to symptomatic upper airway obstruction, can coexist with asthma. Accurate classification has been challenging because of overlapping symptoms and the absence of sensitive diagnostic criteria for either condition. OBJECTIVE: To evaluate patients with concomitant clinical suspicion for inducible laryngeal obstruction and asthma. We used a multidisciplinary protocol incorporating objective diagnostic criteria to determine whether asthma, inducible laryngeal obstruction, both, or neither diagnosis was present...
June 5, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29851434/vaccines-and-atopic-allergic-children-a-survey-among-private-pediatricians
#11
LETTER
Ania Carsin, Marion Cornus, Anderson Loundou, Georges Thiebault, François Vié Le Sage, Jean-Christophe Dubus
The identification, assessment, and management of vaccine reactions, as well as vaccinations of atopic and allergic patients, particularly egg-allergic patients, have received several recent recommendations [1,2]. However, these recommendations are likely to be read mostly by practitioners specialized in infectious diseases or allergy rather than by primary care general practitioners or pediatricians. This article is protected by copyright. All rights reserved.
May 31, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29808611/plasma-metabolite-profiles-in-children-with-current-asthma
#12
Rachel S Kelly, Joanne E Sordillo, Jessica Lasky-Su, Amber Dahlin, Wei Perng, Sheryl L Rifas-Shiman, Scott T Weiss, Diane R Gold, Augusto A Litonjua, Marie-France Hivert, Emily Oken, Ann Chen Wu
BACKGROUND: Identifying metabolomic profiles of children with asthma has the potential to increase understanding of asthma pathophysiology. OBJECTIVE: To identify differences in plasma metabolites between children with and without current asthma at mid-childhood. METHODS: We used untargeted mass spectrometry to measure plasma metabolites in 237 children (46 current asthma cases and 191 controls) in Project Viva, a birth cohort from eastern Massachusetts, USA...
May 28, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29786918/novel-genes-and-insights-in-complete-asthma-remission
#13
Judith M Vonk, Maartje A E Nieuwenhuis, F Nicole Dijk, Anne Boudier, Valerie Siroux, Emmanuelle Bouzigon, Nicole Probst-Hensch, Medea Imboden, Dirk Keidel, Don Sin, Yohan Bossé, Ke Hao, Maarten van den Berge, Alen Faiz, Gerard H Koppelman, Dirkje S Postma
BACKGROUND: Asthma is a chronic respiratory disease without a cure, though there exists spontaneous remission. Genome wide association(GWA) studies have pinpointed genes associated with asthma development, but did not investigate asthma remission. OBJECTIVES: We performed a GWA study to develop insights in asthma remission. METHODS: Clinical remission (ClinR) was defined by absence of asthma treatment and wheezing in the last year and asthma attacks in the last 3 years, and complete remission (ComR) similarly but additionally with normal lung function and absence of bronchial hyperresponsiveness (BHR)...
May 22, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29781543/prospective-predictors-of-exacerbation-status-in-severe-asthma-over-a-3-year-follow-up
#14
Hirokazu Kimura, Satoshi Konno, Hironi Makita, Natsuko Taniguchi, Kaoruko Shimizu, Masaru Suzuki, Hiroki Kimura, Houman Goudarzi, Yuji Nakamaru, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Yoichi M Ito, Sally E Wenzel, Masaharu Nishimura
BACKGROUND: A predisposition to exacerbations is being recognized as a distinct phenotype with "previous exacerbations" representing the strongest clinical factor associated with future exacerbation. Thus, to identify additional novel biomarkers associated with asthma exacerbations, "past exacerbation status" must be included as a confounding factor. OBJECTIVE: This study aimed to characterize the clinical and biomarker features associated with asthma exacerbations in severe asthma...
May 21, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29779231/specialist-perioperative-allergy-clinic-services-in-the-uk-2018-results-from-the-royal-college-of-anaesthetists-sixth-national-audit-project-nap6-investigation-of-perioperative-anaphylaxis
#15
W Egner, T M Cook, T Garcez, S Marinho, H Kemp, D N Lucas, K Floss, S Farooque, H Torevell, M Thomas, K Ferguson, S Nasser, S Karanam, K-L Kong, N McGuire, M Bellamy, A Warner, J Hitchman, L Farmer, N J N Harper
BACKGROUND: The Royal College of Anaesthetists 6th National Audit Project examined Grade 3-5 perioperative anaphylaxis for one year in the UK. OBJECTIVE: To describe the causes and investigation of anaphylaxis in the NAP6 cohort, in relation to published guidance and previous baseline survey results. METHODS: We used a secure registry to gather details of Grade 3-5 perioperative anaphylaxis. Anonymous reports were aggregated for analysis and reviewed in detail...
May 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29777628/allergy-in-the-elderly-case-note-review
#16
N J Gray, E L Redshaw, D Isaacs, M D Tarzi, H E Smith, A J Frew
The prevalence of IgE-mediated disease increased significantly during the 20th century. In developed countries, about 20% of people have atopic disease, which consumes significant amounts of healthcare funding. For example, in UK general practice, allergic conditions account for 6% of consultations and ~10% of prescribing costs [1]. Whilst most studies of allergy focus on children and adolescents, relatively little has been written about allergy in older people, although food allergy may be increasingly common in this group [2]...
May 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29772098/insights-in-particulate-matter-induced-allergic-airway-inflammation-focus-on-the-epithelium
#17
Katrien C De Grove, Sharen Provoost, Guy G Brusselle, Guy F Joos, Tania Maes
Outdoor air pollution is a major environmental health problem throughout the world. In particular, exposure to particulate matter (PM) has been associated with the development and exacerbation of several respiratory diseases, including asthma. Although the adverse health effects of PM have been demonstrated for many years, the underlying mechanisms have not been fully identified. In this review, we focus on the role of the lung epithelium and specifically highlight multiple cytokines in PM-induced respiratory responses...
May 17, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29758111/genetic-profiles-of-transcriptomic-clusters-of-childhood-asthma-determine-specific-severe-subtype
#18
Y-L Yeh, M-W Su, B-L Chiang, Y-H Yang, C-H Tsai, Y L Lee
BACKGROUND: Previous studies have defined transcriptomic subtypes of adult asthma using samples of induced sputum and bronchial epithelium; however, those procedures are not readily applicable in the clinic, especially for childhood asthma. OBJECTIVE: We aim to dissect the transcriptomic clusters of childhood asthma using highly variably expressed genes of peripheral blood mononuclear cells (PBMC) among patients. METHODS: Gene expression of PBMC from 133 asthmatic children and 11 healthy controls was measured with Illumina microarrays...
May 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29758106/sputum-to-serum-hydrogen-sulfide-ratio-as-a-novel-biomarker-of-predicting-future-risks-of-asthma-exacerbation
#19
Yasuhito Suzuki, Junpei Saito, Masami Kikuchi, Manabu Uematsu, Atsuro Fukuhara, Suguru Sato, Mitsuru Munakata
BACKGROUND: Increased level of hydrogen sulfide (H2 S) in sputum is reported to be a new biomarker of neutrophilic airway inflammation in chronic airway disorders. However, the relationship between H2 S and disease activity remains unclear. OBJECTIVE: We investigated whether H2 S levels could vary during different conditions in asthma. METHOD: H2 S levels in sputum and serum were measured using a sulfide-sensitive electrode in 47 stable asthmatic subjects (S-BA), 21 uncontrolled asthmatic subjects (UC-BA), 26 asthmatic subjects with acute exacerbation (AE-BA), and 15 healthy subjects...
May 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29758103/evaluation-of-the-basophil-activation-test-and-skin-prick-testing-for-the-diagnosis-of-sesame-food-allergy
#20
M Y Appel, L Nachshon, A Elizur, M B Levy, Y Katz, M R Goldberg
BACKGROUND: The prevalence of sesame food allergy (SFA) has increased over recent years, with the potential of anaphylactic reactions upon exposure. Oral food challenge (OFC) remains the diagnostic standard, yet its implementation may be risky. Commercial skin prick tests (SPT) have a low sensitivity. Investigation of alternate diagnostic methods is warranted. OBJECTIVE: To evaluate the utility of SPT and the basophil activation test (BAT) for SFA diagnosis. METHODS: Eighty-two patients with suspected SFA completed an open OFC to sesame or reported a recent confirmed reaction...
May 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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