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Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/30508327/are-environmental-risk-factors-for-current-wheeze-in-the-international-study-of-asthma-and-allergies-in-childhood-isaac-phase-three-due-to-reverse-causation
#1
Richard J Silverwood, Charlotte E Rutter, Edwin A Mitchell, M Innes Asher, Luis Garcia Marcos, David P Strachan, Neil Pearce
BACKGROUND: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global prevalence of symptoms of asthma in children. We undertook comprehensive analyses addressing risk factors for asthma symptoms in combination, at both the individual and the school level, to explore the potential role of reverse causation due to selective avoidance or confounding by indication. OBJECTIVE: To explore the role of reverse causation in risk factors of asthma symptoms...
December 3, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30506823/rush-desensitization-with-a-single-antigen-induces-subclinical-activation-of-mast-cells-and-protects-against-bystander-challenge-in-dually-sensitized-mice
#2
Kristin E Killoran, Laura E Kropp, Alyssa R Lindrose, Holly E Curtis, David Cook, Edward Mitre
BACKGROUND: Rush desensitization can provide short-term tolerance to individuals who are allergic to certain medications in instances where other therapeutic interventions are limited. While rush DS is typically successful in preventing adverse type I hypersensitivity reactions, the mechanism of allergic protection remains unknown. Given the rise in prevalence of individuals displaying multiple allergies, understanding the impact of rush DS on "bystander" allergens, or additional allergens to which an individual is sensitized, could help inform clinical recommendations...
December 2, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30506749/an-integrated-framework-using-high-dimensional-mass-cytometry-and-fluorescent-flow-cytometry-identifies-discrete-b-cell-subsets-in-patients-with-red-meat-allergy
#3
Kelly M Cox, Scott P Commins, Brian J Capaldo, Lisa J Workman, Thomas A E Platts-Mills, El-Ad D Amir, Josephine A Lannigan, Alexander J Schuyler, Loren D Erickson
BACKGROUND: B cells play a critical role in the development and maintenance of food allergy by producing allergen-specific IgE. Despite the importance of B cells in IgE-mediated food allergy, the identity of sIgE-producing human B cells and how IgE is regulated are poorly understood. OBJECTIVE: To identify the immunophenotypes of circulating B cells associated with the production of galactose-alpha-1,3-galactose specific IgE production in patients with red meat allergy...
December 2, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30472801/perinatal-probiotic-intervention-prevented-allergic-disease-in-a-caesarean-delivered-subgroup-at-13-year-follow-up
#4
S Kallio, A K Kukkonen, E Savilahti, M Kuitunen
BACKGROUND: The long-term effects of probiotic intervention for primary prevention of allergic diseases are not well known. We previously reported less eczema until 10 years in our probiotic intervention trial. OBJECTIVE: To investigate the effect of early probiotic intervention on the prevalence of allergic diseases up to 13 years of age. METHODS: Pregnant women (n=1223) carrying a child at a high risk of allergy (at least one parent with allergic disease) were randomised to receive a mixture of probiotics (Lactobacillus rhamnosus GG and LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii) or placebo in a double-blind manner from 36 weeks of gestation until birth...
November 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30461089/impact-of-parental-asthma-prenatal-maternal-asthma-control-and-vitamin-d-status-on-risk-of-asthma-and-recurrent-wheeze-in-3-year-old-children
#5
Hooman Mirzakhani, Vincent J Carey, Robert Zeiger, Leonard B Bacharier, George T O'Connor, Michael X Schatz, Nancy Laranjo, Scott T Weiss, Augusto A Litonjua
BACKGROUND: While familial clustering of asthma is known, few studies have reported on the relative roles of paternal and maternal asthma, and the role of maternal asthma control in pregnancy on the risk for asthma in the child. OBJECTIVE: We aimed to investigate the relative roles of paternal asthma, maternal asthma, and maternal asthma control during pregnancy on the risk of asthma or recurrent wheeze in 3-year old children how prenatal and cord blood vitamin D status might affect this risk...
November 21, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30447026/individual-risk-assessment-tool-for-school-age-asthma-prediction-in-uk-birth-cohort
#6
Ran Wang, Angela Simpson, Adnan Custovic, Phil Foden, Danielle Belgrave, Clare S Murray
BACKGROUND: Current published asthma predictive tools have moderate positive likelihood ratios (LR+) but high negative likelihood ratios (-LR) based on their recommended cut-offs, which limit their clinical usefulness. OBJECTIVE: To develop a simple clinically applicable asthma prediction tool within a population-based birth cohort. METHOD: Children from the Manchester Asthma and Allergy Study (MAAS) attended follow-up at ages 3, 8 and 11 years...
November 16, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30431680/follow-up-of-patients-with-negative-drug-provocation-tests-to-betalactams
#7
LETTER
Anca Mirela Chiriac, Antonino Romano, Najah Ben Fadhel, Francesco Gaeta, Nicolas Molinari, Michela Maggioletti, Pascal Demoly
Drug allergy work-up in betalactam (BL) allergy is probably the most-developed drug-allergy evaluation at present [1]. During the last few years, the debate on whether one-day or several-day (prolonged) drug provocation test (DPT) should be performed in non-immediate reactions (i.e., occurring >1h after the last administered dose) in order to increase sensitivity has been ongoing and groups working in drug allergy diagnosis have been deploying pro and con arguments and studies in favour of either option [2-5]...
November 15, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30431203/th2-cell-differentiation-from-naive-cd4-t-cells-is-enhanced-by-autocrine-cc-chemokines-in-atopic-diseases
#8
Hirokuni Hirata, Tatsuo Yukawa, Ayae Tanaka, Tomoyuki Miyao, Takeshi Fukuda, Yasutsugu Fukushima, Kazuhiro Kurasawa, Masafumi Arima
BACKGROUND: Chemokines are involved not only in regulating leukocyte recruitment, but also in other activities. However, functions other than cell recruitment remain poorly understood. We have already shown that the production of CC chemokine ligand (CCL)17 and CCL22 by antigen-stimulated naïve CD4+ T cells was higher in asthmatic patients than in healthy controls. However, the role of these chemokines in stimulated naïve CD4+ T cells remains unclear. OBJECTIVE: To clarify the biological function of CCL17 and CCL22 on naïve CD4+ T, we examined effects of these two chemokines on naïve CD4+ T cells expressing CC chemokine receptor (CCR)4 (a receptor for CCL17 and CCL22) during differentiation of Th2 cells in asthmatic patients as allergic subjects...
November 15, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30418690/germination-of-pollen-grains-in-the-esophagus-of-individuals-with-eosinophilic-esophagitis
#9
Alicia Armentia, Sara Martín Armentia, Rafael Álvarez-Nogal, Blanca Martín Armentia, Manuel José Gayoso, Delia Fernández-González
BACKGROUND: Eosinophilic esophagitis (EoE) is characterized by esophageal dysfunction and, histologically, by eosinophilic inflammation. There is no a clear etiologic treatment. EoE exacerbations are often seasonal. We hypothesized that the inflammatory response of the esophageal mucosa in patients with high levels of antibodies to pollen allergens and worsened seasonal EoE might be due to swallowing airborne pollen and the intrusion into the esophageal mucosa of pollen allergens and pollen tubes, which encounter a pH and humidity resembling the stigma at pollination...
November 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30415509/variability-of-blood-eosinophils-in-patients-in-a-clinic-for-severe-asthma
#10
E Rakowski, S Zhao, M Liu, S Bajaj, N Durmus, G Grunig, M Curotto de Lafaille, Y Wu, J Reibman
BACKGROUND: Blood eosinophils are used to determine eligibility for agents targeting IL-5 in patients with uncontrolled asthma. However, little is known about the variability of blood eosinophil measures in these patients before treatment initiation. OBJECTIVE: To characterize variability and patterns of variability of blood eosinophil levels in a real-world clinic for severe asthmatics. METHODS: Retrospective review of blood eosinophils measured over a 5-year period in patients enrolled in an urban clinic...
November 11, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30415501/dividing-neutrophils-in-subsets-reveals-a-significant-role-for-activated-neutrophils-in-the-development-of-airway-hyperreactivity
#11
Sandra Ekstedt, Jesper Säfholm, Susanna Kumlien Georén, Lars Olaf Cardell
BACKGROUND: Previous research has emphasized the importance of eosinophils in allergic asthma, while paying less attention to neutrophils. The known functionality of neutrophils in the inflammatory process has recently changed and knowledge about subsets of neutrophils, as characterized by their expression of CD16 and CD62L, has surfaced. Their specific roles in asthma are still unknown. OBJECTIVE: To study the functional differences between subsets of neutrophils by characterising the impact of individual subsets on airway smooth muscle reactivity...
November 11, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30415484/traffic-related-air-pollution-induces-non-allergic-eosinophilic-airway-inflammation-and-cough-hypersensitivity-in-guinea-pigs
#12
Zhangfu Fang, Chuqin Huang, Junfeng Jim Zhang, Jiaxing Xie, Shouhui Dai, Erjia Ge, Juan Xiang, Hongmei Yao, Rongquan Huang, Xinhui Bi, Boguang Wang, Nanshan Zhong, Kefang Lai
BACKGROUND: The pathogenesis and pathophysiology of eosinophilia-related chronic cough such as non-asthmatic eosinophilic bronchitis and cough variant asthma are still not clear. OBJECTIVE: This study is to examine the potential role of traffic-related air pollution (TRAP) in eosinophilic inflammation and cough responses. METHODS: Non-sensitized guinea pigs were exposed to TRAP in an urban traffic tunnel or kept in a filtered air environment for 7 or 14 days...
November 11, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30415478/antihistamine-resistant-chronic-spontaneous-urticaria-1-year-data-from-the-aware-study
#13
M Maurer, U Raap, P Staubach, G Richter-Huhn, A Bauer, E M Oppel, U Hillen, D Baeumer, M Reinhardt, N Chapman-Rothe
BACKGROUND: Previous reports indicate that patients with chronic spontaneous urticaria (CSU) are undertreated and that physicians show poor adherence to guideline recommendations. Awareness of CSU has improved in recent years, but it remains unclear if this has improved the management of these patients in clinical practice. OBJECTIVE: To describe disease burden, quality of life (QoL), and treatment patterns of patients with H1 -antihistamine-refractory CSU in Germany...
November 11, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30408255/the-basophil-activation-test-reduces-the-need-for-a-food-challenge-test-in-children-suspected-of-ige-mediated-cow-s-milk-allergy
#14
Janneke Ruinemans-Koerts, Yvonne Schmidt-Hieltjes, A D Jansen, Huub F J Savelkoul, Annejet Plaisier, Petra van Setten
BACKGROUND: The gold standard for the diagnosis of cow's milk allergy is the Double-Blind Placebo-Controlled Food Challenge (DBPCFC) test. However, disadvantages of the DBPCFC are the potential risk of anaphylactic reactions, the time consuming procedure and high costs. OBJECTIVE: The aim of this study is to determine the reliability of the Basophil Activation Test (BAT) both for the initial diagnosis of cow's milk allergy in children and for determination of tolerance in children with cow's milk allergy...
November 8, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30407672/low-dose-provocation-and-skin-tests-in-patients-with-hypersensitivity-to-gadolinium-based-contrast-agents
#15
LETTER
Vannina Seta, Hafida Gaouar, Antoine Badaoui, Camille Francès, Annick Barbaud, Angèle Soria
Reported reactions rates with gadolinium-based contrast agents (GBCA) ranged from 0.07 to 2.4%, the rate of hypersensitivity reaction (HS) is around 0.1% (1) and immediate and delayed HS have been reported (1-4). The diagnosis of HS to GBCA is challenging, based on clinical history and skin tests. Although little data is available on the performances of the GBCA skin tests, its negative predictive value appears to be of interest (5). This article is protected by copyright. All rights reserved.
November 8, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30383313/blocking-antibodies-induced-by-peanut-oral-and-sublingual-immunotherapy-suppress-basophil-activation-and-are-associated-with-sustained-unresponsiveness
#16
Kelly Orgel, Caitlin Burk, Johanna Smeekens, Jada Suber, Lakeya Hardy, Rishu Guo, A Wesley Burks, Michael Kulis
BACKGROUND: Oral and sublingual immunotherapies for peanut allergy have demonstrated efficacy in small clinical trials, however, mechanisms and biomarkers correlating with clinical outcomes remain elusive. Previous studies have demonstrated a role for IgG in post-OIT plasma in the suppression of IgE-mediated mast cell reactions. OBJECTIVE: The aim of this study was to characterize the role that peanut oral and sublingual immunotherapy-induced plasma factors play in the inhibition of ex vivo basophil activation and whether inhibitory activity is associated with clinical outcomes...
November 1, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30379368/fevipiprant-a-dp-2-receptor-antagonist-inhibits-eosinophil-migration-towards-mast-cells
#17
LETTER
Revital Shamri, Gerald Dubois, Veit J Erpenbeck, David Mankuta, David A Sandham, Francesca Levi-Schaffer
No abstract text is available yet for this article.
October 31, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30365193/fixed-airflow-obstruction-relates-to-eosinophil-activation-in-asthmatics
#18
Ida Mogensen, Kjell Alving, Sven-Erik Dahlen, Anna James, Bertil Forsberg, Junya Ono, Shoichiro Ohta, Per Venge, Magnus Borres, Kenji Izuhara, Christer Janson, Andrei Malinovschi
BACKGROUND: Some asthmatics develop irreversible chronic airflow obstruction, e.g., fixed airflow obstruction (fixed-AO). This is probably a consequence of airway remodeling, but neither its relation to inflammation, nor which asthma biomarkers can be clinically useful are elucidated. We hypothesized that the presence of type-2 inflammation relates to fixed-AO. OBJECTIVES: Evaluate the presence of four markers for type-2 inflammation in fixed airflow obstruction among asthmatics...
October 26, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30353972/combined-administration-of-anti-il-13-and-anti-il-17a-at-individually-sub-therapeutic-doses-limits-asthma-like-symptoms-in-a-mouse-model-of-th2-th17-high-asthma
#19
Dasom Kim, Jaclyn W McAlees, Lindsay J Bischoff, Davinder Kaur, Lauren K Houshel, Jerilyn Gray, Julie Hargis, Xenia Davis, Paul L Dudas, Hitesh Deshmukh, Ian P Lewkowich
BACKGROUND: Recent studies have demonstrated that Th2 responses have the ability to antagonize Th17 responses. In mouse models of allergic asthma, blockade of Th2-effector cytokines results in elaboration of Th17 responses and associated increases in pulmonary neutrophilia. While these can be controlled by simultaneous blockade of Th17-associated effector cytokines, clinical trials of anti-IL-17/IL-17RA blocking therapies have demonstrated increased of risk of bacterial and fungal infections...
October 24, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30326160/bradykinin-mechanism-is-the-main-responsible-for-death-by-isolated-asphyxiating-angioedema-in-france
#20
LETTER
Julia Crochet, Marion Lepelley, Nassima Yahiaoui, Céline Vermorel, Jean-Luc Bosson, Pauline Pralong, Marie Thérèse Leccia, Laurence Bouillet
Angioedema (AE) is a sudden localized, subcutaneous or submucosal, swelling due to one of two major possible mechanisms: mast cell induced (MC-AE) or bradykinin mediated (BkAE). MC-AE may be allergic or non-allergic (mast cell degranulation non-specific to the antigen). BkAE may be hereditary, with (C1-INH-HAE) or without C1 inhibitor (C1-INH) deficiency. BkAE may also be acquired with C1-INH deficiency (C1-INH-AAE), complicating some blood diseases, dysimmunities or be iatrogenic, mainly due to angiotensin converting enzyme inhibitors (ACEi)...
October 16, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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