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Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/30099793/identification-of-gibberellin-regulated-protein-as-a-new-allergen-in-orange-allergy
#1
N Inomata, M Miyakawa, N Ikeda, K Oda, M Aihara
BACKGROUND: To date, three orange allergens have been reported. However, it is still unclear whether gibberellin-regulated proteins (GRPs), identified as new allergens in other fruit allergies, are also involved in orange allergy. OBJECTIVE: To investigate the allergenicity of orange GRP and to determine the clinical characteristics of patients with orange allergy who are sensitized to orange GRP. METHODS: We enrolled 14 patients (4 men, 10 women, mean age 29...
August 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30091213/dietary-patterns-and-respiratory-health-in-adults-from-nine-european-countries-evidence-from-the-ga-2-len-study
#2
Ioannis Bakolis, Richard Hooper, Claus Bachert, Bibi Lange, Tari Haahtela, Thomas Keil, Stephanie Hofmaier, Wytske Fokkens, Barbara Rymarczyk, Christer Janson, Peter G J Burney, Vanessa Garcia-Larsen
BACKGROUND: Dietary patterns defined using Principal Component Analysis (PCA) offer an alternative to the analysis of individual foods and nutrients and have been linked with asthma and allergic disease. However, results have not been reproducible in different settings. OBJECTIVE: To identify dietary patterns common to different European countries and examine their associations with asthma and allergic symptoms. METHODS: In sixteen study centres in nine European countries, 3206 individuals aged 15-77 years completed a common, internationally validated, Food Frequency Questionnaire and a respiratory symptoms questionnaire...
August 9, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30084516/soluble-cd14-concentration-in-human-breast-milk-and-its-potential-role-in-child-atopic-dermatitis-results-of-the-ulm-birth-cohort-studies
#3
Chad A Logan, Johannes M Weiss, Wolfgang Koenig, Bernd Stahl, Prudence R Carr, Hermann Brenner, Dietrich Rothenbacher, Jon Genuneit
BACKGROUND: Soluble CD14 (sCD14) is one of many factors in human breast milk which may influence programming of the immune response in the breastfed child. Though previous studies have mostly found little association between sCD14 concentration in breast milk and atopic outcomes, recent evidence continues to support a role of sCD14 in immune-related disease. OBJECTIVE: We aimed to clarify whether an association exists between sCD14 concentration in human breast milk (m-sCD14) and child atopic dermatitis (AD) diagnosis by age 3 years within the context of two large birth cohorts...
August 7, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30084510/inhibition-of-h3k27me3-demethylases-attenuates-asthma-by-reversing-the-shift-in-airway-smooth-muscle-phenotype
#4
Qijun Yu, Xiaowei Yu, Wenxue Zhao, Manni Zhu, Zhengxia Wang, Jiaxiang Zhang, Mao Huang, Xiaoning Zeng
BACKGROUND: The shift in airway smooth muscle cells (ASMCs) phenotype between proliferation and contraction during asthma has been reported recently, highlighting a role of ASMCs plasticity in the pathophysiology of asthma. As an event involved in epigenetic post-translational modification, histone H3 lysine27 (H3K27) demethylation has attracted significant attention with respect to the epigenetic changes in diverse cells; however, little is known about its contribution to the switching of ASMCs phenotype in asthma...
August 7, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30079619/efficacy-and-safety-of-allergen-immunotherapy-in-patients-with-allergy-to-molds-a-systematic-review
#5
Danilo Di Bona, Flavia Frisenda, Marcello Albanesi, Gabriele Di Lorenzo, Maria Filomena Caiaffa, Luigi Macchia
BACKGROUND: Allergen immunotherapy (AIT) with mold extracts has been performed for many years but the final demonstration of its clinical efficacy is still missing, due to the small number of studies and their inconsistent results. OBJECTIVE: To systematically review efficacy and safety of AIT for the treatment of respiratory allergies to molds. DESIGN: The primary outcomes were safety and reduction of symptoms (Symptom Score, SS) and medication use (Medication Score, MS) in patients treated with AIT compared to controls...
August 6, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30044028/sensitization-to-hymenoptera-venom-marker-allergens-prevalence-predisposing-factors-and-clinical-implications
#6
Johanna Stoevesandt, Christine Hosp, Andreas Kerstan, Axel Trautmann
BACKGROUND: The prevalence and predisposing factors of asymptomatic sensitization to Hymenoptera venom marker allergens are largely unknown. OBJECTIVE: To evaluate sensitization profiles in a group of 490 dermatologic patients without a history of sting-induced anaphylaxis. METHODS: Clinical data were collected using a structured questionnaire; sera were tested for total IgE and specific IgE to venom preparations, recombinant venom marker allergens, inhalative allergens, and cross-reactive carbohydrate determinants...
July 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30028047/tumstatin-fragment-selectively-inhibits-neutrophil-infiltration-in-experimental-asthma-exacerbation
#7
Gyde Nissen, Henrike Hollaender, Francesca S M Tang, Michael Wegmann, Lars Lunding, Christina Vock, Anna Bachmann, Solveig Lemmel, Rainer Bartels, Brian G Oliver, Janette K Burgess, Tim Becker, Matthias V Kopp, Markus Weckmann
BACKGROUND: Asthma is a chronic inflammatory disease with structural changes present. Burgess and colleagues recently found tumstatin markedly reduced in adult asthmatic lung tissue compared to non-asthmatics. ECM-fragments such as tumstatin are named matrikines and act independently of the parent molecule. The role of Col IV matrikines in neutrophil inflammation (e.g. exacerbation in asthma) have not been investigated to date. Severe adult asthma phenotypes are dominated by neutrophilic inflammation and show a high frequency of severe exacerbations...
July 20, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30025179/asian-children-living-in-australia-have-a-different-profile-of-allergy-and-anaphylaxis-than-australian-born-children-a-state-wide-survey
#8
Yichao Wang, Katrina J Allen, Noor H A Suaini, Rachel L Peters, Anne-Louise Ponsonby, Jennifer J Koplin
BACKGROUND: Asian children born in Australia have higher rates of eczema and nut allergy than non-Asian children. However, it is not known whether this country of birth differential exists for other allergies or anaphylaxis risk. OBJECTIVE: We investigated the influence of maternal and child's country of birth on the prevalence of parent-reported eczema, asthma, food allergy, and being diagnosed by a doctor as being "at risk of anaphylaxis". METHODS: We assessed the relationship between mother and child country of birth and allergies using the 2010 School Entrant Health Questionnaire, completed for 57,005 5-year old children (85...
July 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30019503/does-allergy-explain-why-some-children-have-severe-asthma
#9
K Bonner, G Roberts
Asthma is a common disease in childhood with a minority of affected children having severe asthma. Children with severe asthma can be differentiated from those with mild-moderate disease by greater allergic sensitisation and increased airway inflammation. Many children with asthma have co-existing allergic disease. Increasing severity of allergic rhinitis is associated with increasing severity of asthma, even after adjustment for atopy. Food allergy seems to be a particularly strong marker of severe asthma...
July 17, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30004599/lysozyme-a-new-allergen-in-donkey-s-milk
#10
LETTER
Matteo Martini, Kyra Swiontek, Leonardo Antonicelli, Maria Stella Garritani, Maria Beatrice Bilò, Gianni Mistrello, Stefano Amato, Dominique Revets, Markus Ollert, Martine Morisset, Christiane Hilger
In addition to its cosmetic properties, well known since antiquity, donkey's milk (DM) has gained attention as a substitute for cow's milk (CM) in CM allergic patients. Different mammalian milks have been investigated in order to find valid alternatives of CM, which is highly cross-reactive with goat's and sheep's milk proteins, but not with camel, horse milk (HM) and DM, which are tolerated by more than 80% of CM allergic children. However, anaphylactic reactions to DM were reported in few of these children2 and in one adult...
July 13, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29999223/electronic-clinical-decision-support-system-for-allergic-rhinitis-management
#11
A-L Courbis, R Murray, S Arnavielhe, D Caimmi, A Bedbrook, M Van Eerd, G De Vries, G Dray, I Agache, M Morais-Almeida, C Bachert, K C Bergmann, S Bosnic-Anticevich, J Brozek, C Bucca, P Camargos, G W Canonica, W Carr, T Casale, Jaoa A Fonseca, T Haahtela, O Kalayci, L Klimek, P Kuna, V Kvedariene, D Larenas Linnemann, P Lieberman, J Mullol, R Ohehir, N G Papadopoulos, D Price, D Ryan, B Samolinski, F E Simons, P Tomazic, M Triggiani, A Valiulis, E Valovirta, M Wagenmann, M Wickman, A Yorgancioglu, J Bousquet
BACKGROUND: Allergic rhinitis (AR) management has changed in recent years following the switch from the concept of disease severity to the concept of disease control, publication of the AR clinical decision support system (CDSS) and development of mobile-health (m-health) tools for patients (e.g. Allergy Diary). The Allergy Diary Companion app for health care providers is currently being developed and will be launched in 2018. It incorporates the AR CDSS to provide evidence based treatment recommendations, linking all key stakeholders in AR management...
July 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29998524/population-pharmacokinetics-of-subcutaneous-c1-inhibitor-for-prevention-of-attacks-in-patients-with-hereditary-angioedema
#12
Dipti Pawaskar, Michael A Tortorici, Bruce Zuraw, Timothy Craig, Marco Cicardi, Hilary Longhurst, H Henry Li, William R Lumry, Inmaculada Martinez-Saguer, Joshua Jacobs, Jonathan A Bernstein, Marc A Riedl, Constance H Katelaris, Paul K Keith, Annette Feussner, Jagdev Sidhu
BACKGROUND: Long-term prophylaxis with subcutaneous (SC) administration of a highly concentrated plasma-derived C1 esterase inhibitor (C1-INH) formulation was recently approved by the Food and Drug Administration for hereditary angioedema (HAE) attack prevention. OBJECTIVE: To characterize the population pharmacokinetics of C1-INH (SC) (HAEGARDA® ; CSL Behring) in healthy volunteers and HAE patients, and assess the variability and influence of covariates on pharmacokinetics...
July 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29992665/tropomyosins-in-mosquito-and-house-dust-mite-cross-react-at-the-humoral-and-cellular-level
#13
J F Cantillo, L Puerta, E Fernandez-Caldas, J L Subiza, I Soria, S Wöhrl, C Ebner, W Keller, Y Resch-Marat, S Vrtala, B Bohle
BACKGROUND: Aedes aegypti and Dermatophagoides pteronyssinus contain important allergens including cross-reactive tropomyosins. However, the functional and clinical relevance of their cross-reactivity is still debated. OBJECTIVE: To analyse the humoral and cellular cross-reactivity of recombinant Aed a 10.01, Aed a 10.02, and Der p 10. METHODS: Sera from 15 Austrian house dust mite-allergic, Der p 10-sensitized individuals were tested for IgE-reactivity to recombinant tropomyosins in ELISA, inhibition ELISA and basophil activation tests...
July 10, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29992645/gly-m-5-gly-m-8-fusion-component-as-a-potential-novel-candidate-molecule-for-diagnosing-soybean-allergy-in-japanese-children
#14
Nobuyuki Maruyama, Sakura Sato, Cerrone Cabanos, Akira Tanaka, Komei Ito, Motohiro Ebisawa
BACKGROUND: Soybean is a major food allergen in children. Component-resolved diagnostics has improved the accuracy of diagnosing immunoglobulin E (IgE)-mediated food allergies. OBJECTIVE: We aimed to develop a novel component for the diagnosis of soybean allergy using recombinant technology. METHODS: Japanese paediatric patients with suspected soybean allergy (n = 91) were included, and symptomatic (n = 40) and asymptomatic (n = 51) cases were divided through oral food challenge testing...
July 10, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29978510/anti-inflammatory-effects-of-the-gag-binding-cxcl9-74-103-peptide-in-dinitrofluorobenzene-induced-contact-hypersensitivity-in-mice
#15
Vincent Vanheule, Helena Crijns, Fariba Poosti, Pieter Ruytinx, Nele Berghmans, Tanja Gerlza, Isabelle Ronsse, Noëmie Pörtner, Patrick Matthys, Andreas J Kungl, Ghislain Opdenakker, Sofie Struyf, Paul Proost
BACKGROUND: To recruit leukocytes to an inflammatory site, chemokine binding to glycosaminoglycans (GAGs) is critical. Therefore, strategies to interfere with this interaction, aiming at the production of anti-inflammatory agents, were developed. These include production of modified chemokines without affinity for G protein-coupled receptors but with enhanced affinity for GAGs. Such modified chemokines compete with functional chemokines for GAG-binding, prevent chemokine immobilization and presentation, and inhibit leukocyte migration...
July 6, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29975808/high-ambient-levels-of-grass-weed-and-other-pollens-are-associated-with-asthma-admissions-in-children-and-adolescents-a-large-5-year-case-crossover-study
#16
Som Kumar Shrestha, Constance Katelaris, Shyamali C Dharmage, Pamela Burton, Don Vicendese, Rachel Tham, Michael J Abramson, Bircan Erbas
BACKGROUND: Pollen is an important aeroallergen that triggers asthma exacerbations in children, but we know little about the impact of different pollen types in cities with varying climatic conditions and pollen seasons. OBJECTIVES: We aimed to assess the role of ambient level of different types of pollen on a large time series of child and adolescent asthma hospitalizations in Sydney, Australia. METHODS: Childhood asthma hospitalization and the daily ambient pollen concentrations of different species were collected in South-West Sydney...
July 5, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29975807/towards-complete-identification-of-allergens-in-jack-jumper-myrmecia-pilosula-ant-venom-and-their-clinical-relevance-an-immunoproteomic-approach
#17
Troy Wanandy, Richard Wilson, David Gell, Hayley E Rose, Nuri Gueven, Noel W Davies, Simon G A Brown, Michael D Wiese
BACKGROUND: The venomous stings of Jack Jumper ant (JJA; species of the Myrmecia pilosula taxonomic group) are a significant public health issue in parts of south-eastern and south-western Australia, causing anaphylaxis in approximately three percent of the population. Three allergenic peptides, Myr p 1, Myr p 2, and Myr p 3, and one histamine-releasing peptide, pilosulin 5, have been fully described, but there are at least five additional high molecular weight IgE-binding components that have not been identified...
July 5, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29975437/prevalence-of-allergy-to-human-seminal-fluid-among-women-with-allergy-to-male-dog-and-sensitization-to-can-f-5
#18
LETTER
David González-de-Olano, Mar Gandolfo-Cano, María P de-Calzada-Bustingorri, Eloína González-Mancebo, Ana de-Andrés-Martín, Javier Cuesta-Herranz, Borja Bartolomé-Zavala, Carlos Pastor-Vargas
The number of households with pets is progressively increasing. The amount of registered dogs in our country arises up to over 5 million, and they are currently the main pet.1 It is estimated that 27% of European adults coming to the clinic for suspected allergy to inhalant allergens are sensitized to dogs,2 and mammal epithelia are the third cause of rhinitis and asthma after dust mites and pollen in Spain.3 This article is protected by copyright. All rights reserved.
July 5, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29974988/identification-of-peptides-with-tolerogenic-potential-in-a-hydrolyzed-whey-based-infant-formula
#19
Joost W Gouw, Juandy Jo, Laura A P M Meulenbroek, Sam Heijjer, Erica Kremer, Elena Sandalova, André C Knulst, Prescilla Jeurink, Johan Garssen, Anneke Rijnierse, Léon M J Knippels
BACKGROUND: Failure to induce oral tolerance may result in food allergy. Hydrolyzed cow's milk-based infant formulas are recommended in subjects with a high risk of developing allergic disease. Presentation of T-cell epitopes is a prerequisite to generate regulatory T cells that could contribute to oral tolerance. OBJECTIVE: To investigate whether a specific hydrolyzed whey-based infant formula contains peptides that function as T-cell epitopes to support the development of oral tolerance to whey...
July 5, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29957871/threshold-stimulated-kallikrein-activity-distinguishes-bradykinin-from-histamine-mediated-angioedema
#20
M L Lara-Marquez, S C Christiansen, M A Riedl, J Herschbach, B L Zuraw
BACKGROUND: The lack of specific biomarkers makes the diagnosis of hereditary angioedema (HAE) with normal levels of C1-inhibitor (C1INH) protein (HAE-nl-C1INH) and idiopathic non-histaminergic angioedema (INHA) difficult. Confirming or excluding these diagnoses is a significant challenge for clinicians evaluating patients with angioedema. OBJECTIVE: To develop a reliable biomarker that would aid the diagnosis of HAE-nl-C1INH and INHA. METHODS: 154 consecutive patients referred for angioedema at a single center were enrolled and evaluated...
June 29, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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