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Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

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https://www.readbyqxmd.com/read/29676834/working-while-unwell-workplace-impairment-in-people-with-severe-asthma
#1
Sarah A Hiles, Erin S Harvey, Vanessa M McDonald, Matthew Peters, Philip Bardin, Paul N Reynolds, John W Upham, Melissa Baraket, Zaheerodin Bhikoo, Jeffrey Bowden, Ben Brockway, Li Ping Chung, Belinda Cochrane, Gloria Foxley, Jeffrey Garrett, Mark Hew, Lata Jayaram, Christine Jenkins, Constance Katelaris, Gregory Katsoulotos, Mariko S Koh, Vicky Kritikos, Marina Lambert, David Langton, Alexis Lara Rivero, Guy B Marks, Peter G Middleton, Aldoph Nanguzgambo, Naghmeh Radhakrishna, Helen Reddel, Janet Rimmer, Anne Marie Southcott, Michael Sutherland, Francis Thien, Peter Ab Wark, Ian A Yang, Elaine Yap, Peter G Gibson
BACKGROUND: Severe asthma affects quality of life; however, its impact on workplace productivity is poorly understood. OBJECTIVE: To compare workplace productivity - absenteeism and presenteeism - and impairment in daily activities in severe and non-severe asthma over time and identify characteristics associated with presenteeism in severe asthma. METHODS: The Severe Asthma Web-based Database (SAWD) is an ongoing observational registry from Australia, New Zealand and Singapore...
April 20, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29676818/new-insights-into-the-phenotypes-of-atopic-dermatitis-linked-with-allergies-and-asthma-in-children-an-overview
#2
F Amat, A Soria, P Tallon, M Bourgoin-Heck, N Lambert, A Deschildre, J Just
Atopic dermatitis (AD) is a complex disease with multiple causes and complex mechanistic pathways according to age of onset, severity of the illness, ethnic modifiers, response to therapy, and triggers. A group of difficult-to-manage patients characterized by early-onset AD and severe lifelong disease associated with allergic asthma and/or food allergy, has been identified. In this paper, we focus on these severe phenotypes, analyzing their links with other atopic comorbidities, and taking into account the results from recent cohort studies and meta-analyses...
April 20, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29671921/the-basophil-proteome-in-chronic-spontaneous-urticaria-distinguishes-responders-to-omalizumab-from-non-responders
#3
LETTER
Jenny M Stitt, Monika Dzieciatkowska, Michael G Edwards, Kirk Hansen, Garrett Hedlund, Stephen C Dreskin
Chronic spontaneous urticaria (CSU) is a disease of unknown etiology in which urticarial lesions are present for 6 weeks or more, without an apparent trigger. Although the pathophysiology of the condition is unclear, there is a documented association between disease activity and blood basophil number and function. CSU patients are basopenic, and those with the most severe symptoms have the lowest number of basophils. This article is protected by copyright. All rights reserved.
April 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29671917/threshold-dose-distribution-for-cashew-nut-allergy-in-children
#4
LETTER
Amandine Divaret-Chauveau, Isabelle Clerc-Urmès, Jean-Marie Renaudin, Vanina Cordebar, Pascale Dumond, Cyril Schweitzer
Allergy to cashew nut in children is increasingly recognized in clinical practice and the prevalence of this allergy seems to increase. Furthermore, previous studies showed the potential for cashew nut to cause anaphylaxis [1]. Despite the increasing prevalence of cashew nut allergy and the severity of the reaction to this allergen, there are only few studies on this allergy, especially on the threshold dose. This article is protected by copyright. All rights reserved.
April 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29665158/peanut-gastro-intestinal-delivery-oral-immunotherapy-in-adolescents-results-of-the-build-up-phase-of-a-randomized-double-blind-placebo-controlled-trial-pita-study
#5
Jean-Luc Fauquert, Elodie Michaud, Bruno Pereira, Lise Bernard, Nelly Gourdon-Dubois, Paul-Olivier Rouzaire, Emmanuelle Rochette, Etienne Merlin, Bertrand Evrard
BACKGROUND: Oral immunotherapy to peanut is effective in desensitizing patients but has significant side effects including anaphylaxis and gastro-intestinal symptoms. In most protocols peanut is administered in a vehicle food. OBJECTIVE: In an exclusively adolescent population, we tested a new approach using sealed capsules of peanut (Gastro-Intestinal Delivery Oral Immunotherapy or GIDOIT) in order to bypass the upper gastro-intestinal tract. The primary aim was to assess the efficacy of the oral build-up phase of GIDOIT and the secondary aim to analyse its safety...
April 17, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29665127/proteomic-analysis-of-serum-and-sputum-analytes-distinguishes-controlled-and-poorly-controlled-asthmatics
#6
Marion T Kasaian, Julie Lee, Agnes Brennan, Spencer I Danto, Kendall E Black, Lori Fitz, Anne E Dixon
BACKGROUND: A major goal of asthma therapy is to achieve disease control, with maintenance of lung function, reduced need for rescue medication, and prevention of exacerbation. Despite current standard of care, up to 70% of patients with asthma remain poorly controlled. Analysis of serum and sputum biomarkers could offer insights into parameters associated with poor asthma control. OBJECTIVE: To identify signatures as determinants of asthma disease control, we performed proteomics using Olink proximity extension analysis...
April 17, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29608226/clinical-implications-of-food-allergen-threshold
#7
François Graham, Philippe A Eigenmann
Food allergy has increased in recent decades and has a major impact on patients' quality of life. There is currently no treatment in routine clinical practice and patients are often faced with accidental reactions. Precautionary allergen labeling (PAL) has been used by the food industry to attempt to minimize this risk, although not standardized and often ambiguous. Estimating the risk of reacting to traces in foods is complicated by heterogeneous amounts of allergens in foods with precautionary labeling and individual variability of reaction thresholds...
April 2, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29603809/management-of-hypersensitivity-reactions-to-tocilizumab
#8
LETTER
Pauline Tétu, Aurore Hamelin, Philippe Moguelet, Annick Barbaud, Angèle Soria
Following their increased use, monoclonal antibodies (mAbs) hypersensitivity reactions (HSR) have become more frequent and can occur after the first exposure or after multiple exposures. The immunological mechanisms of these HSR have not been fully elucidated. Infusion reactions can be "cytokine storm-like" reactions or direct complement activation but a drug-specific IgE mediated mast cell activation can also be involved. This article is protected by copyright. All rights reserved.
March 31, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29603800/remodeling-and-inflammation-in-preschoolers-with-severe-recurrent-wheeze-and-asthma-outcome-at-school-age
#9
Guillaume Lezmi, Antoine Deschildre, Rola Abou Taam, Michael Fayon, Sylvain Blanchon, Françoise Troussier, Philippe Mallinger, Bruno Mahut, Philippe Gosset, Jacques de Blic
BACKGROUND: The influence of airway remodeling and inflammation in preschoolers with severe recurrent wheeze on asthma outcomes is poorly understood. OBJECTIVE: To assess their association with asthma symptoms and lung function at school age. METHODS: Preschoolers (38.4 months) initially investigated with bronchial biopsies were re-assessed for asthma symptoms and lung function at school age. RESULTS: Thirty six of 49 preschoolers (73...
March 31, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29575336/simultaneously-elevated-feno-and-blood-eosinophils-relate-to-asthma-morbidity-in-asthmatics-from-nhanes-2007-12
#10
Ida Mogensen, Kjell Alving, Tiago Jacinto, João A Fonseca, Christer Janson, Andrei Malinovschi
BACKGROUND: Fraction of exhaled nitric oxide (FeNO) and blood eosinophil (B-Eos) count are biomarkers for type 2 inflammation. However, they signal different inflammatory pathways. Simultaneously elevated, they are related to more asthma events in a general population and among younger asthmatics. OBJECTIVE: To investigate if simultaneously elevated FeNO and B-Eos relate to asthma outcomes and lung function among subjects with asthma at a wide age span, and how different cut offs for the markers affect these relations...
March 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29575251/treatment-for-moderate-to-severe-atopic-dermatitis-at-alpine-and-moderate-maritime-climates-differentially-affect-helper-t-cells-and-memory-b-cells-in-children
#11
Jorn J Heeringa, Karin B Fieten, Finola M Bruins, Els van Hoffen, Edward F Knol, Suzanne G M A Pasmans, Menno C van Zelm
BACKGROUND: Treatment of atopic dermatitis (AD) is focused on topical anti-inflammatory therapy, epidermal barrier repair and trigger avoidance. Multidisciplinary treatment in both moderate maritime and alpine climates can successfully reduce disease activity in children with AD. However, it remains unclear whether abnormalities in B- and T-cell memory normalize and if this differs between treatment strategies. OBJECTIVE: To determine whether successful treatment in maritime and alpine climates normalises B- and T-lymphocytes in children with moderate to severe AD...
March 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29575216/variation-in-the-association-of-der-p-1-and-der-f-1-with-asthma-and-rhinitis-in-9-11-years-old-schoolchildren-the-french-six-cities-study
#12
LETTER
Shreosi Sanyal, Nour Baïz, Denis Andre Charpin, Caillaud Denis, Frédéric De Blay, François Lavaud, Chantal Raherison, Isabella Annesi-Maesano
Allergic asthma and rhinitis largely occur due to atopic sensitization to different allergens. Several studies have firmly established that allergic sensitization to indoor dust mites, as assessed by specific immunoglobulin E (IgE) or skin prick tests to specific allergens, is significantly related to respiratory allergic symptoms [1-4]. Among the house dust mites, Dermatophagoides pteronyssinus (Der p 1) and Dermatophagoides farinae (Der f 1) are the most potent mites that can cause an exacerbation in the case of allergic rhinitis and asthma [5]...
March 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29575179/sensitisation-to-minor-cat-allergen-components-is-associated-with-type-2-biomarkers-in-young-asthmatics
#13
N Tsolakis, A Malinovschi, L Nordvall, L Mattsson, J Lidholm, C Pedroletti, C Janson, M P Borres, K Alving
BACKGROUND: Cat allergy is a major trigger of asthma worldwide. Molecular patterns of cat sensitisation vary between individuals, but their relationship to inflammation in asthmatics has not been extensively studied. OBJECTIVE: To investigate the prevalence and levels of IgE antibodies against different cat allergen components and their relationship to type-2 inflammation and total IgE among young asthmatic subjects sensitised to furry animals. METHODS: Patients with asthma (age 10-35 years; n=266) and IgE sensitisation to cat, dog or horse extract (ImmunoCAP), were analysed for IgE to the cat allergen components Fel d 1 (secretoglobin), Fel d 2 (serum albumin), Fel d 4 and Fel d 7 (lipocalins)...
March 25, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29573024/barriers-and-facilitators-to-self-management-of-asthma-in-adolescents-an-interview-study-to-inform-development-of-a-novel-intervention
#14
Simone Holley, Dawn Walker, Rebecca Knibb, Sue Latter, Christina Liossi, Frances Mitchell, Ruth Radley, Graham Roberts
BACKGROUND AND OBJECTIVE: Despite literature that spans twenty years describing the barriers to asthma self-management in adolescents, successful, clinically-based interventions to address this important issue are lacking. Given the limitations of some of the previous studies, we conducted a study that aimed to gain a broader insight into barriers and facilitators to self-management of asthma by adolescents, not just adherence to treatment, and triangulated their views with those of their parents and healthcare professionals...
March 23, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29570230/association-between-the-age-of-solid-food-introduction-and-eczema-a-systematic-review-and-a-meta-analysis
#15
Nilakshi T Waidyatillake, Shyamali C Dharmage, Katrina Allen, Gayan Bowatte, Robert Boyle, John Burgess, Jennifer Koplin, Vanessa Garcia-Larsen, Adrian J Lowe, Caroline Lodge
INTRODUCTION: Eczema is a common childhood ailment responsible for a considerable disease burden. Both timing of introduction to solid food and allergenic food are believed to be related to childhood eczema. Despite the growing body of evidence, the relationship between timing of any solid food introduction (allergenic and/or non-allergenic) and development of eczema has not previously been systematically reviewed. METHODS: PubMed and EMBASE databases were searched using food and eczema terms...
March 23, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29542223/2s-protein-ara-h-7-0201-has-unique-epitopes-compared-to-other-ara-h-7-isoforms-and-is-comparable-to-2s-proteins-ara-h-2-and-6-in-basophil-degranulation-capacity
#16
S M Hayen, A M Ehlers, C F den Hartog Jager, J Garssen, E F Knol, A C Knulst, W Suer, L E M Willemsen, H G Otten
BACKGROUND: Screening for specific IgE against 2S albumin proteins Ara h 2 and 6 has good positive predictive value in diagnosing peanut allergy. From the third 2S member Ara h 7, three isoforms have been identified. Their allergenicity has not been elucidated. OBJECTIVE: This study investigated the allergenicity of Ara h 7 isoforms compared to Ara h 2 and 6. METHODS: Sensitization of 15 DBPCFC confirmed peanut allergic patients to recombinant Ara h 2...
March 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29526044/effects-of-personal-air-pollution-exposure-on-asthma-symptoms-lung-function-and-airway-inflammation
#17
Lucy Chambers, Joanne Finch, Karen Edwards, Antoine Jeanjean, Roland Leigh, Sherif Gonem
BACKGROUND: There is evidence that air pollution increases the risk of asthma hospitalisations and healthcare utilisation, but the effects on day-to-day asthma control are not fully understood. OBJECTIVE: We undertook a prospective single-centre panel study to test the hypothesis that personal air pollution exposure is associated with asthma symptoms, lung function and airway inflammation. METHODS: Thirty-two patients with a clinical diagnosis of asthma were provided with a personal air pollution monitor (Cairclip NO2 /O3 ) which was kept on or around their person throughout the 12-week follow-up period...
March 11, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29520864/complex-association-patterns-for-inflammatory-mediators-in-induced-sputum-from-subjects-with-asthma
#18
A T Hastie, C Steele, C W Dunaway, W C Moore, B M Rector, E Ampleford, H Li, L C Denlinger, N Jarjour, D A Meyers, E R Bleecker
BACKGROUND: The release of various inflammatory mediators into the bronchial lumen is thought to reflect both the type and degree of airway inflammation, eosinophilic Th2, and Th9, or neutrophilic Th1, and Th17, in patients with asthma. AIMS: We investigated whether cytokines and chemokines differed in sputum from subjects with more severe compared with milder asthma, and if unbiased factor analysis of cytokine and chemokine groupings indicates specific inflammatory pathways...
March 9, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29513401/novel-innate-and-adaptive-lymphocytes-the-new-players-in-the-pathogenesis-of-inflammatory-upper-airway-diseases
#19
Y Liu, Y Yao, Z-C Wang, Q Ning, Z Liu
Host immunity (innate and adaptive immunity) plays essential roles in the pathogenesis of inflammatory upper airway diseases, including allergic rhinitis and chronic rhinosinusitis. Recently, the discovery of novel innate immune cells, particularly innate lymphoid cells, has renewed our view on the role of innate immunity in inflammatory upper airway diseases. Meanwhile, the identification of new subsets of T helper (Th) cells, including Th22, Th9 and follicular Th cells, and regulatory B cells in the adaptive immunity, has broadened our knowledge on the complex immune networks in inflammatory upper airway diseases...
March 7, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29513367/the-familial-aggregation-of-atopic-diseases-and-depression-or-anxiety-in-children
#20
Bronwyn K Brew, Cecilia Lundholm, Tong Gong, Henrik Larsson, Catarina Almqvist
BACKGROUND: Children with asthma and atopic diseases have an increased risk of depression or anxiety. Each of these diseases have strong genetic and environmental components, therefore it seems likely that there is a shared liability rather than causative risk. OBJECTIVE: To investigate the existence and nature of familial aggregation for the comorbidity of atopic diseases and depression or anxiety. METHODS: Participants came from the Childhood and Adolescent Twin Study in Sweden (CATSS), n= 14197...
March 7, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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