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https://www.readbyqxmd.com/read/28810062/the-association-between-patient-attitudes-and-values-and-the-strength-of-consideration-for-contralateral-prophylactic-mastectomy-in-a-population-based-sample-of-breast-cancer-patients
#1
Sarah T Hawley, Kent A Griffith, Ann S Hamilton, Kevin C Ward, Monica Morrow, Nancy K Janz, Steven J Katz, Reshma Jagsi
BACKGROUND: Little is known about how the individual decision styles and values of breast cancer patients at the time of treatment decision making are associated with the consideration of different treatment options and specifically with the consideration of contralateral prophylactic mastectomy (CPM). METHODS: Newly diagnosed patients with early-stage breast cancer who were treated in 2013-2014 were identified through the Surveillance, Epidemiology, and End Results registries of Los Angeles and Georgia and were surveyed approximately 7 months after surgery (n = 2578; response rate, 71%)...
August 15, 2017: Cancer
https://www.readbyqxmd.com/read/28787086/advances-in-the-diagnosis-of-hereditary-kidney-cancer-initial-results-of-a-multigene-panel-test
#2
Kevin A Nguyen, Jamil S Syed, Carin R Espenschied, Holly LaDuca, Ansh M Bhagat, Alfredo Suarez-Sarmiento, Timothy K O'Rourke, Karina L Brierley, Erin W Hofstatter, Brian Shuch
BACKGROUND: Panel testing has been recently introduced to evaluate hereditary cancer; however, limited information is available regarding its use in kidney cancer. METHODS: The authors retrospectively reviewed test results and clinical data from patients who underwent targeted multigene panel testing of up to 19 genes associated with hereditary kidney cancer from 2013 to 2016. The frequency of positive (mutation/variant likely pathogenic), inconclusive (variant of unknown significance), and negative results was evaluated...
August 8, 2017: Cancer
https://www.readbyqxmd.com/read/28786207/three-year-cytohistological-correlation-of-salivary-gland-fna-cytology-at-a-tertiary-center-with-the-application-of-the-milan-system-for-risk-stratification
#3
Manish Rohilla, Priya Singh, Arvind Rajwanshi, Nalini Gupta, Radhika Srinivasan, Pranab Dey, Rakesh K Vashishta
BACKGROUND: Fine-needle aspiration (FNA) cytology of salivary glands is a well-established technique that plays a critical role in the preoperative diagnosis of lesions. A risk stratification of FNA diagnostic categories has been recently proposed to be useful in reporting. The aims of this study were to evaluate the diagnostic accuracy of salivary gland FNA and to apply the proposed Milan system for reporting salivary gland lesions. METHODS: A retrospective audit of FNA specimens of salivary gland lesions reported from 2014 to 2016 was performed...
August 7, 2017: Cancer
https://www.readbyqxmd.com/read/28786105/double-blind-randomized-phase-3-trial-of-low-dose-13-cis-retinoic-acid-in-the-prevention-of-second-primaries-in-head-and-neck-cancer-long-term-follow-up-of-a-trial-of-the-eastern-cooperative-oncology-group-acrin-cancer-research-group-c0590
#4
Aarti K Bhatia, Ju-Whei Lee, Harlan A Pinto, Charlotte D Jacobs, Paul J Limburg, Philip Rubin, Robert M Arusell, Eamonn P Dunphy, Janardan D Khandekar, Seth A Reiner, Luis Baez-Diaz, Paul Celano, Shuli Li, Yi Li, Barbara A Burtness, George L Adams, Kishan J Pandya
BACKGROUND: 13-Cis retinoic acid (13-CRA) is a synthetic vitamin A derivative. High-dose 13-CRA in patients with squamous cell cancers of the head and neck (SCCHNs) reduces the incidence of second primary tumors (SPTs). The authors report long-term results from a phase 3 randomized trial that compared treatment with low-dose 13-CRA versus placebo for patients who had early stage SCCHN, with a focus on the development of SPTs and overall survival (OS). METHODS: In total, 176 patients who received treatment for stage I/II SCCHN were randomized to receive either low-dose 13-CRA (weight-based dose of 7...
August 7, 2017: Cancer
https://www.readbyqxmd.com/read/28782114/cancer-survivorship-and-opioid-prescribing-rates-a-population-based-matched-cohort-study-among-individuals-with-and-without-a-history-of-cancer
#5
Rinku Sutradhar, Armend Lokku, Lisa Barbera
BACKGROUND: Little is known about opioid prescribing among individuals who have survived cancer. Our aim is to examine a predominantly socio-economically disadvantaged population for differences in opioid prescribing rates among cancer survivors compared with matched controls without a prior diagnosis of cancer. METHODS: This was a retrospective population-wide matched cohort study. Starting in 2010, individuals residing in Ontario, Canada, who were 18 to 64 years of age and at least 5 years past their cancer diagnosis were matched to controls without a prior cancer diagnosis based on sex and calendar year of birth...
August 7, 2017: Cancer
https://www.readbyqxmd.com/read/28759174/next-generation-learning-and-training-the-cy-test-experience
#6
Ambrogio Fassina, Rocco Cappellesso, Martin Tötsch, Helena Barroca, Caterina Marchiò, Roberto Dina, Emanuela Ovcin, Gianni Bussolati
No abstract text is available yet for this article.
July 31, 2017: Cancer
https://www.readbyqxmd.com/read/28759154/the-evolving-role-of-cytopathology-in-the-era-of-neoadjuvant-chemotherapy-for-the-accurate-pathologic-diagnosis-of-epithelial-ovarian-cancer
#7
https://www.readbyqxmd.com/read/28759150/adequate-sampling-of-multiple-thyroid-nodules-by-fine-needle-aspiration
#8
Andrew A Renshaw, Ewing W Gould
BACKGROUND: Recommendations regarding how many nodules to biopsy with thyroid fine-needle aspiration vary. METHODS: The authors reviewed fine-needle aspiration specimens of 12,763 nodules from 10,506 patients and correlated them with the number of nodules biopsied. RESULTS: Compared with patients in whom only a single nodule was biopsied, patients in whom multiple nodules were biopsied were found to be significantly younger, more likely female, and to have larger tumors, and those tumors were more often papillary (all P<...
July 31, 2017: Cancer
https://www.readbyqxmd.com/read/28759121/health-care-disparities-among-octogenarians-and-nonagenarians-with-stage-ii-and-iii-rectal-cancer
#9
Richard J Cassidy, Jeffrey M Switchenko, En Cheng, Renjian Jiang, Jaymin Jhaveri, Kirtesh R Patel, Daniel G Tanenbaum, Maria C Russell, Conor E Steuer, Theresa W Gillespie, Mark W McDonald, Jerome C Landry
BACKGROUND: Octogenarians and nonagenarians with stage II/III rectal adenocarcinomas are underrepresented in the randomized trials that have established the standard-of-care therapy of preoperative chemoradiation followed by definitive resection (ie, chemoradiation and then surgery [CRT+S]). The purpose of this study was to evaluate the impact of therapies on overall survival (OS) for patients with stage II/III rectal cancers and determine predictors of therapy within the National Cancer Data Base (NCDB)...
July 31, 2017: Cancer
https://www.readbyqxmd.com/read/28759114/nonrhabdomyosarcoma-soft-tissue-sarcoma-nrsts-in-pediatric-and-young-adult-patients-results-from-a-prospective-study-using-limited-margin-radiotherapy
#10
Christopher L Tinkle, Israel Fernandez-Pineda, April Sykes, Zhaohua Lu, Chia-Ho Hua, Michael D Neel, Armita Bahrami, Barry L Shulkin, Sue C Kaste, Alberto Pappo, Sheri L Spunt, Matthew J Krasin
BACKGROUND: Indications for and delivery of adjuvant therapies for pediatric nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) have been derived largely from adult studies; therefore, significant concern remains regarding radiation exposure to normal tissue. The authors report long-term treatment outcomes and toxicities for pediatric and young adult patients with high-grade NRSTS who were treated on a prospective trial using limited-margin radiotherapy. METHODS: Sixty-two patients (ages 3-22 years) with predominantly high-grade NRSTS requiring radiation were treated on a phase 2 institutional study of conformal external-beam radiotherapy and/or brachytherapy using a 1...
July 31, 2017: Cancer
https://www.readbyqxmd.com/read/28759113/feasibility-and-preliminary-effects-of-resistance-training-and-nutritional-supplements-during-versus-after-radiotherapy-in-patients-with-head-and-neck-cancer-a-pilot-randomized-trial
#11
Jon Arne Sandmael, Asta Bye, Tora Skeidsvoll Solheim, Guro Birgitte Stene, Lene Thorsen, Stein Kaasa, Jo-Åsmund Lund, Line Merethe Oldervoll
BACKGROUND: Patients with head and neck cancer (HNC) experience involuntary weight loss that has a negative impact on physical function, morbidity, and survival. The objective of the current study was to evaluate the feasibility of an exercise and nutrition intervention during radiotherapy (RT) compared with after RT, and to examine preliminary effects on skeletal muscle mass. METHODS: Patients with HNC were randomized to an exercise and nutrition intervention during RT (EN-DUR) or after RT (EN-AF)...
July 31, 2017: Cancer
https://www.readbyqxmd.com/read/28759109/probing-the-phosphatidylinositol-3-kinase-mammalian-target-of-rapamycin-pathway-in-gliomas-a-phase-2-study-of-everolimus-for-recurrent-adult-low-grade-gliomas
#12
Michael Wahl, Susan M Chang, Joanna J Phillips, Annette M Molinaro, Joseph F Costello, Tali Mazor, Sanda Alexandrescu, Janine M Lupo, Sarah J Nelson, Mitchel Berger, Michael Prados, Jennie W Taylor, Nicholas Butowski, Jennifer L Clarke, Daphne Haas-Kogan
BACKGROUND: Activation of the phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is common in patients with low-grade gliomas (LGGs), but agents that inhibit this pathway, including mTOR inhibitors, have not been studied in this population. METHODS: Fifty-eight patients with pathologic evidence of recurrence after they had initially been diagnosed with World Health Organization (WHO) grade II gliomas were enrolled into a prospective phase 2 clinical trial and received daily everolimus (RAD001) for 1 year or until progression...
July 31, 2017: Cancer
https://www.readbyqxmd.com/read/28759108/a-call-for-action-increasing-enrollment-of-untreated-patients-with-higher-risk-myelodysplastic-syndromes-in-first-line-clinical-trials
#13
REVIEW
Amer M Zeidan, Maximilian Stahl, Mikkael A Sekeres, David P Steensma, Rami S Komrokji, Steven D Gore
Hypomethylating agents (HMAs) have changed the landscape of the management of patients with higher-risk myelodysplastic syndromes (HR-MDS). HMAs have improved hematopoiesis and quality of life and, in the case of azacitidine, prolonged survival in a large randomized trial. However, multiple real-life and registry analyses have demonstrated minimal survival gains at the population level after the approval of HMAs. Furthermore, the 24-month median survival observed with azacitidine in the landmark AZA-001 trial has not been replicated in population-based studies or in other clinical trials using azacitidine monotherapy arms...
July 31, 2017: Cancer
https://www.readbyqxmd.com/read/28759103/contribution-of-solid-organ-transplant-recipients-to-the-pediatric-non-hodgkin-lymphoma-burden-in-the-united-states
#14
Elizabeth L Yanik, Meredith S Shiels, Jodi M Smith, Christina A Clarke, Charles F Lynch, Amy R Kahn, Lori Koch, Karen S Pawlish, Eric A Engels
BACKGROUND: Pediatric solid organ transplant recipients have a 100 to 200 times higher risk of non-Hodgkin lymphoma (NHL) than the general pediatric population. Consequently, transplant-related NHL may contribute considerably to the pediatric NHL burden in the United States. METHODS: A cohort study using a linkage between the US transplant registry and 16 cancer registries was conducted. Cancer incidence rates were calculated for people less than 20 years old in the transplant and general populations...
July 31, 2017: Cancer
https://www.readbyqxmd.com/read/28753230/a-centralized-mailed-program-with-stepped-increases-of-support-increases-time-in-compliance-with-colorectal-cancer-screening-guidelines-over-5-years-a-randomized-trial
#15
Beverly B Green, Melissa L Anderson, Andrea J Cook, Jessica Chubak, Sharon Fuller, Richard T Meenan, Sally W Vernon
BACKGROUND: Screening over many years is required to optimize reductions in colorectal cancer (CRC) mortality. However, no prior trials have compared strategies for obtaining long-term adherence. METHODS: Systems of Support to Increase Colorectal Cancer Screening and Follow-Up was implemented in an integrated health care organization in Washington State. Between 2008 and 2009, 4675 individuals aged 50 to 74 years were randomized to receive the usual care (UC), which included clinic-based strategies to increase CRC screening (arm 1), or, in years 1 and 2, mailings with a call-in number for colonoscopy and mailed fecal tests (arm 2), mailings plus brief telephone assistance (arm 3), or mailings and assistance plus nurse navigation (arm 4)...
July 28, 2017: Cancer
https://www.readbyqxmd.com/read/28749548/c-myc-positive-relapsed-and-refractory-diffuse-large-b-cell-lymphoma-impact-of-additional-hits-and-outcomes-with-subsequent-therapy
#16
Narendranath Epperla, Kami J Maddocks, Mohammed Salhab, Julio C Chavez, Nishitha Reddy, Reem Karmali, Elvira Umyarova, Veronika Bachanova, Cristiana Costa, Martha Glenn, Oscar Calzada, Ana C Xavier, Zheng Zhou, Nasheed M Hossain, Francisco J Hernandez-Ilizaliturri, Zeina Al-Mansour, Stefan K Barta, Saurabh Chhabra, Frederick Lansigan, Amitkumar Mehta, Michael V Jaglal, Andrew Evans, Christopher R Flowers, Jonathon B Cohen, Timothy S Fenske, Mehdi Hamadani, Luciano J Costa
BACKGROUND: The impact of MYC proto-oncogene, basic helix-loop-helix (MYC) translocations (with or without additional rearrangements involving the B-cell lymphoma 2 [BCL2] or BCL6 genes) on the response to salvage therapy and survival in patients with diffuse large B-cell lymphoma (DLBCL) who experience primary treatment failure is not well defined. METHODS: This was a multicenter, retrospective study of the impact of MYC, BCL2, and BCL6 rearrangements in patients with DLBCL who failed to achieve complete remission or relapsed within 6 months after they completed upfront chemoimmunotherapy...
July 27, 2017: Cancer
https://www.readbyqxmd.com/read/28749536/the-lack-of-a-relationship-between-physician-payments-from-drug-manufacturers-and-medicare-claims-for-abiraterone-and-enzalutamide
#17
Jathin Bandari, Omar M Ayyash, Robert M Turner, Bruce L Jacobs, Benjamin J Davies
BACKGROUND: Interactions between industry and prescribers have raised concerns regarding conflicts of interest. To the best of the authors' knowledge, quantitative data measuring these interactions have been limited until recently. In the current study, the authors sought to determine whether an association exists between industry payments and prescriber behavior with regard to abiraterone and enzalutamide. METHODS: Two Centers for Medicare and Medicaid Services databases were combined to analyze oncologists and urologists who received industry payments and/or prescribed abiraterone and enzalutamide...
July 27, 2017: Cancer
https://www.readbyqxmd.com/read/28746789/cytogenetic-clonal-evolution-in-myelodysplastic-syndromes-is-associated-with-inferior-prognosis
#18
Judith Neukirchen, Michael Lauseker, Barbara Hildebrandt, Ann-Christin Nolting, Jennifer Kaivers, Guido Kobbe, Norbert Gattermann, Rainer Haas, Ulrich Germing
BACKGROUND: The karyotype of bone marrow cells at the time of diagnosis is a strong prognostic parameter for overall survival as well as acute myeloid leukemia (AML) progression in patients with myelodysplastic syndromes (MDS). However, to the authors' knowledge, few data exist regarding the prognostic impact of cytogenetic clonal evolution during the course of MDS. METHODS: The authors evaluated follow-up karyotype analyses in 549 patients from the Dusseldorf MDS Registry...
July 26, 2017: Cancer
https://www.readbyqxmd.com/read/28746751/cancer-donor-preferences-for-disposition-of-their-biospecimens-after-biobank-closure
#19
Samuel C Allen, Margie D Dixon, Jeffrey M Switchenko, Rebecca D Pentz
BACKGROUND: Biobank funding is unstable and biobank administrators are concerned about loss of funding and subsequent biobank closure. Nevertheless, only a minority of biobanks have policies regarding the distribution or destruction of tissue if the biobank were to close. To the authors' knowledge, the current study is the first to report on the preferences of oncology biospecimen donors regarding the handling of their biospecimens in the event of biobank closure. METHODS: A total of 98 biospecimen donors who were diagnosed with cancer at the Georgia Cancer Center for Excellence at Grady Memorial Hospital or the Winship Cancer Institute were interviewed concerning their preferences for the handling of their biospecimens in the event of biobank closure...
July 26, 2017: Cancer
https://www.readbyqxmd.com/read/28743170/current-trends-in-patient-enrollment-for-robotic-assisted-laparoscopic-prostatectomy-in-belgium
#20
Simone Albisinni, Steven Joniau, Thierry Quackels, Greet De Coster, Peter Dekuyper, Ben Van Cleynenbreugel, Nancy Van Damme, Elisabeth Van Eycken, Filip Ameye, Thierry Roumeguère
BACKGROUND: During the last decade, an inverse stage migration has been observed in radical prostatectomy series at tertiary centers. However, it remains unclear whether similar trends can also be observed in solely robotic practices, including nonreferral centers. The aim of this study was to investigate the clinical and pathological trends in robotic-assisted laparoscopic prostatectomy (RALP) enrollment in Belgium over a period of 6 years through an analysis of a prospective registry...
July 25, 2017: Cancer
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