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Andrea L Canada, Patricia E Murphy, Kevin D Stein, Kassandra I Alcaraz, George Fitchett
BACKGROUND: Existing research indicates that religion, spirituality, or both are important to the quality of life of patients with cancer. The current study is the first to characterize trajectories of spiritual well-being (SWB) over time and to identify their predictors in a large, diverse sample of long-term cancer survivors. METHODS: The participants were 2365 cancer survivors representing 10 cancer diagnoses from the American Cancer Society's Studies of Cancer Survivors-I, and they were assessed at 3 time points: 1, 2, and 9 years after their diagnosis...
January 11, 2019: Cancer
Gunn Ammitzbøll, Christoffer Johansen, Charlotte Lanng, Elisabeth Wreford Andersen, Niels Kroman, Bo Zerahn, Ole Hyldegaard, Merete Celano Wittenkamp, Susanne Oksbjerg Dalton
BACKGROUND: Existing research suggests that progressive resistance training (PRT) after breast cancer (BC) surgery is safe, but the preventive effect on arm lymphedema has yet to be determined. METHODS: Women aged 18 to 75 years who were undergoing BC surgery with axillary lymph node dissection were eligible for the study. Recruited on the day of surgery, participants were allocated to intervention or usual care by computer randomization. The intervention consisted of PRT 3 times per week: in the first 20 weeks as a supervised group exercise and in the last 30 weeks as a self-administered exercise...
January 11, 2019: Cancer
Chloe J Taub, Marc E Lippman, Barry I Hudson, Bonnie B Blomberg, Alain Diaz, Hannah M Fisher, Erica R Nahin, Suzanne C Lechner, Taekyoung Kwak, Gyong Ha Hwang, Michael H Antoni
BACKGROUND: Women with breast cancer (BCa) experience heightened distress, which is related to greater inflammation and poorer outcomes. The s100 protein family facilitates the inflammatory response by regulating myeloid cell function through the binding of Toll-like receptor 4 and the receptor for advanced glycation end products (RAGE). The heterodimer s100A8/A9 RAGE ligand is associated with hastened tumor development and metastasis. Previously, a 10-week stress-management intervention using cognitive behavioral therapy (CBT) and relaxation training (RT) was associated with less leukocyte inflammatory gene expression in patients with BCa; however, its impact on s100A8/A9 was not examined...
January 11, 2019: Cancer
Katherine H Ross, Keerthi Gogineni, Preeti D Subhedar, Jolinta Y Lin, Lauren E McCullough
No abstract text is available yet for this article.
January 11, 2019: Cancer
Christine M Veenstra, Lauren P Wallner, Paul H Abrahamse, Nancy K Janz, Steven J Katz, Sarah T Hawley
BACKGROUND: Patients with breast cancer involve multiple decision support persons (DSPs) in treatment decision making, yet little is known about DSP engagement in decision making and its association with patient appraisal of the decision process. METHODS: Patients newly diagnosed with breast cancer reported to Georgia and Los Angeles Surveillance, Epidemiology, and End Results registries in 2014-2015 were surveyed 7 months after their diagnosis. The individual most involved in each respondent's decision making (the key DSP) was surveyed...
January 11, 2019: Cancer
Stephen Grant, Mona Kamal, Abdallah S R Mohamed, Jhankruti Zaveri, Martha P Barrow, G Brandon Gunn, Stephen Y Lai, Jan S Lewin, David I Rosenthal, Xin Shelley Wang, Clifton D Fuller, Katherine A Hutcheson
BACKGROUND: Two patient-reported outcomes (PROs) of swallowing and their correlation to quality of life (QOL) were compared in long-term survivors of oropharyngeal cancer (OPC). METHODS: Scores on the single dysphagia item from the 28-item, multisymptom MD Anderson Symptom Inventory-Head and Neck (MDASI-HN-S) were compared with scores on the dysphagia-specific composite MD Anderson Dysphagia Inventory (MDADI) and the EuroQol visual analog scale (EQ-VAS) in 714 patients who had received definitive radiotherapy ≥12 months before the survey...
January 11, 2019: Cancer
Alexander P Cole, Sean A Fletcher, Sebastian Berg, Junaid Nabi, Brandon A Mahal, Guru P Sonpavde, Paul L Nguyen, Stuart R Lipsitz, Maxine Sun, Toni K Choueiri, Mark A Preston, Adam S Kibel, Quoc-Dien Trinh
BACKGROUND: There are race-based differences in bladder cancer survival. To better understand this phenomenon, this study was designed to assess the statistical contributions of tumor, treatment, and access variables to race-based differences in survival. METHODS: Data were extracted from the National Cancer Data Base on black and white adults with muscle-invasive bladder cancer from 2004 to 2015. The impact of tumor, access, and treatment variables on differences in survival was inferred by the performance of sequential propensity score-weighted analyses in which black and white patients were balanced with respect to demographics and health status (comorbidities) tumor characteristics, treatment, and access-related variables...
January 11, 2019: Cancer
Todd M Gibson, Gregory T Armstrong, Leslie L Robison
No abstract text is available yet for this article.
January 9, 2019: Cancer
Christina Signorelli, Claire E Wakefield, Joanna E Fardell, Mary-Ellen Brierley, Anne-Sophie Darlington, Jane Williamson, Peter Downie, Richard J Cohn
No abstract text is available yet for this article.
January 9, 2019: Cancer
Jean L Koff, Edmund K Waller
In an article published in this issue of Cancer, D'Arcy et al link the incidence of cancer among recipients of solid organ transplantation (SOT) in the Scientific Registry of Transplant Recipients with data from regional and statewide cancer registries to examine cancer-specific mortality for common malignancies in SOT recipients. This analysis helps to illuminate the role of immune surveillance across a broad range of malignancies and compares the incidence of cancers due to virally mediated oncogenesis (lymphoma, squamous cell carcinoma of the aerodigestive epithelium, and hepatitis-induced liver cancer) with the incidence of other malignancies...
January 9, 2019: Cancer
Monica E D'Arcy, Anna E Coghill, Charles F Lynch, Lori A Koch, Jie Li, Karen S Pawlish, Cyllene R Morris, Chandrika Rao, Eric A Engels
BACKGROUND: Transplant recipients have an elevated risk of cancer because of immunosuppressive medications used to prevent organ rejection, but to the authors' knowledge no study to date has comprehensively examined associations between transplantation status and mortality after a cancer diagnosis. METHODS: The authors assessed cases in the US general population (N=7,147,476) for 16 different cancer types as ascertained from 11 cancer registries. The presence of a solid organ transplant prior to diagnosis (N=11,416 cancer cases) was identified through linkage with the national transplantation registry (1987-2014)...
January 9, 2019: Cancer
Sumanta K Pal, Andres Forero-Torres, John A Thompson, John C Morris, Saurabh Chhabra, Christopher J Hoimes, Nicholas J Vogelzang, Thomas Boyd, Paulo G Bergerot, Jacob J Adashek, Hong Li, Xuesong Yu, Elaina M Gartner, Anne-Sophie Carret, David C Smith
BACKGROUND: Cluster of differentiation 70 (CD70) is frequently expressed in renal cell carcinoma (RCC) and has immunomodulatory properties. An antibody-drug conjugate targeting CD70, SGN-CD70A, was developed to treat patients with CD70-positive RCC. METHODS: The objective of this phase 1, open-label, dose-escalation, multicenter study was to evaluate the safety and tolerability of SGN-CD70A and establish its maximum tolerated dose in patients with CD70-positive, metastatic RCC (mRCC)...
January 9, 2019: Cancer
Janet K Papadakos, Rebecca C Charow, Christine J Papadakos, Lesley J Moody, Meredith E Giuliani
BACKGROUND: The benefits of patient-reported outcome measures (PROMs) are well known; however, their readability has come into question because multiple PROMs have been found to be incomprehensible to patients. This is a critical safety and equity consideration because PROMs are increasingly being integrated into routine clinical practice. A key strategy for promoting patient comprehension is the use of plain language. The aim of this study was to determine whether PROMs routinely used in the cancer setting meet plain-language best practices...
January 8, 2019: Cancer
Anthony P Y Liu, Camden Hastings, Shengjie Wu, Johnnie K Bass, Andrew M Heitzer, Jason Ashford, Robert Vestal, Mary E Hoehn, Yahya Ghazwani, Sahaja Acharya, Heather M Conklin, Frederick Boop, Thomas E Merchant, Amar Gajjar, Ibrahim Qaddoumi
BACKGROUND: Low-grade gliomas (LGGs) and low-grade glioneuronal tumors (LGGNTs) diagnosed during the first year of life carry unique clinical characteristics and challenges in management. However, data on the treatment burden, outcomes, and morbidities are lacking. METHODS: A retrospective study of LGGs and LGGNTs diagnosed in patients younger than 12 months at St. Jude Children's Research Hospital (1986-2015) was conducted. RESULTS: For the 51 patients (including 31 males), the mean age at diagnosis was 6...
January 8, 2019: Cancer
Carminia M Della Corte, Carl M Gay, Lauren A Byers
No abstract text is available yet for this article.
January 8, 2019: Cancer
Guru Sonpavde, Neeraj Agarwal, Gregory Russell Pond, Rebecca J Nagy, Roberto H Nussenzveig, Andrew W Hahn, Oliver Sartor, Theodore Stewart Gourdin, Lakshminarayanan Nandagopal, Elisa M Ledet, Gurudatta Naik, Andrew J Armstrong, Jue Wang, Mehmet Asim Bilen, Shilpa Gupta, Petros Grivas, Sumanta K Pal, Richard B Lanman, AmirAli Talasaz, Michael B Lilly
BACKGROUND: Because cell-free DNA (cfDNA) analysis facilitates the noninvasive genomic profiling of metastatic castration-resistant prostate cancer (mCRPC), the authors evaluated the association between cfDNA alterations and outcomes and evolution with therapy. METHODS: Patients with mCRPC underwent cfDNA genomic profiling using Guardant360, which examines major cancer-associated genes. Clinical factors, therapy information, failure-free survival, and overall survival (OS) were obtained for select patients...
January 8, 2019: Cancer
Amit Tirosh, Sanjit Mukherjee, Justin Lack, Sudheer Kumar Gara, Sophie Wang, Martha M Quezado, Xavier M Keutgen, Xiaolin Wu, Maggie Cam, Suresh Kumar, Dhaval Patel, Naris Nilubol, Monica Varun Tyagi, Electron Kebebew
BACKGROUND: Aberrant methylation is a known cause of cancer initiation and/or progression. There are scant data on the genome-wide methylation pattern of nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) and sporadic and hereditary NFPanNETs. METHODS: Thirty-three tissue samples were analyzed: they included samples from sporadic (n = 9), von Hippel-Lindau (VHL)-related (n = 10), and multiple endocrine neoplasia type 1 (MEN1)-related NFPanNETs (n = 10) as well as normal islet cells (n = 4) for comparison...
January 8, 2019: Cancer
Ronac Mamtani, Xin Victoria Wang, Bishal Gyawali, Robert S DiPaola, C Neill Epperson, Naomi B Haas, Janice P Dutcher
BACKGROUND: In phase 3 trials of patients with resected high-risk renal cell carcinoma, adjuvant sunitinib has demonstrated no overall survival (OS) benefit, an uncertain disease-free survival (DFS) benefit, and increased toxicity versus placebo. To identify patients who may derive benefit or harm from adjuvant therapy, the authors assessed the effects of age and sex on treatment outcomes in the phase 3 Adjuvant Sorafenib or Sunitinib for Unfavorable Renal Cancer (ASSURE) trial. METHODS: The authors conducted a post hoc subgroup analysis of age and sex among patients in the ASSURE trial...
January 8, 2019: Cancer
Erin E Hahn, Yi-Lin Wu, Corrine E Munoz-Plaza, Jazmine Garcia Delgadillo, Robert M Cooper, Chun R Chao
BACKGROUND: Hodgkin lymphoma (HL) is a leading cancer diagnosis for adolescents and young adults (AYAs), with an overall 5-year survival rate of >80%. However, to the authors' knowledge, little is known regarding posttreatment patterns of care. In the current study, the authors characterized the use of guideline-recommended services in a cohort of AYA survivors of HL in Kaiser Permanente Southern California. METHODS: Patients with HL who were diagnosed between ages 15 and 39 years between 2000 and 2010 were identified...
January 8, 2019: Cancer
Sebastian Berg, David D'Andrea, Malte W Vetterlein, Alexander Cole, Sean A Fletcher, Marieke J Krimphove, Maya Marchese, Stuart R Lipsitz, Guru Sonpavde, Joachim Noldus, Shahrokh F Shariat, Adam S Kibel, Quoc-Dien Trinh, Matthew Mossanen
BACKGROUND: The use of adjuvant chemotherapy (AC) in pure urothelial carcinoma of the bladder is established. Regarding variant histology, there is a gap in knowledge concerning the optimal treatment after radical cystectomy (RC). The objective of this study was to assess the effect of AC on overall survival (OS) in patients who had pure urothelial carcinoma, urothelial carcinoma with concomitant variant histology, or another pure variant histology. METHODS: Within the National Cancer Data Base, 15,397 patients who underwent RC for nonmetastatic, localized carcinoma of the bladder and had positive lymph nodes (T2N+) or locally advanced stage (≥T3N0/N+) were identified, excluding those who had previously received neoadjuvant chemotherapy...
January 8, 2019: Cancer
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