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Alison T Brenner, Jewels Rhode, Jeff Y Yang, Dana Baker, Rebecca Drechsel, Marcus Plescia, Daniel S Reuland, Tom Wroth, Stephanie B Wheeler
BACKGROUND: Colorectal cancer (CRC) screening is effective but underused. Screening rates are lower among Medicaid beneficiaries versus other insured populations. No studies have examined mailed fecal immunochemical testing (FIT)-based outreach programs for Medicaid beneficiaries. METHODS: In a patient-level randomized controlled trial, a mailed CRC screening reminder plus FIT, sent from an urban health department to Medicaid beneficiaries, was compared with the same reminder without FIT...
July 13, 2018: Cancer
Andrew Kolarich, Thomas J George, Steven J Hughes, Daniel Delitto, Carmen J Allegra, William A Hall, George J Chang, Sanda A Tan, Christiana M Shaw, Atif Iqbal
BACKGROUND: The incidence of rectal cancer in patients younger than 50 years is increasing. To test the hypothesis that the biology in this younger cohort may differ, this study compared survival patterns, stratifying patients according to National Comprehensive Cancer Network (NCCN) guideline-driven care and age. METHODS: The National Cancer Data Base was queried for patients treated with curative-intent transabdominal resections with negative surgical margins for stage I to III rectal cancer between 2004 and 2014...
July 9, 2018: Cancer
Matthew F Kalady
No abstract text is available yet for this article.
July 9, 2018: Cancer
James L Klosky, Vicky Lehmann, Jessica S Flynn, Yin Su, Hui Zhang, Kathryn M Russell, Lauren A M Schenck, Leslie R Schover
BACKGROUND: Although survivors of adolescent-onset cancers are at risk of infertility, the majority desire children. Fertility preservation options are available for adolescents, but sperm banking remains underused. To the authors' knowledge, patient factors that influence decisions to bank sperm are poorly understood. METHODS: A cross-sectional study of 146 adolescent males who were newly diagnosed with cancer and who completed surveys within 1 week of treatment initiation was performed...
July 5, 2018: Cancer
Douglas B Johnson
No abstract text is available yet for this article.
July 5, 2018: Cancer
Filippo Alongi, Stefanie Corradini, Stefano Arcangeli
No abstract text is available yet for this article.
July 5, 2018: Cancer
Alexander T Faje, Donald Lawrence, Keith Flaherty, Christine Freedman, Riley Fadden, Krista Rubin, Justine Cohen, Ryan J Sullivan
BACKGROUND: It remains unclear whether high doses of glucocorticoids have a negative impact on the efficacy of checkpoint inhibitors. To control for the potential association between immune-related adverse events (irAEs) and improved survival, this study examined a unique cohort of patients who had the same irAE treated with varying glucocorticoid doses. METHODS: In total, 98 patients with melanoma who had ipilimumab-induced hypophysitis were identified retrospectively in the Partners Healthcare system using an automated electronic medical record query tool...
July 5, 2018: Cancer
Suzanne E Dahlberg, Robert J Gray
No abstract text is available yet for this article.
July 5, 2018: Cancer
Andrew Krane, Lauren Terhorst, Dana H Bovbjerg, Michael F Scheier, Barbara Kucinski, David A Geller, Wallis Marsh, Allan Tsung, Jennifer L Steel
BACKGROUND: The aim of this study was to examine predictors of health behaviors over time and the link between health behaviors and survival after a diagnosis of advanced cancer. METHODS: Patients with a diagnosis of advanced cancer were administered a battery of questionnaires measuring optimism, depressive symptoms, physical activity, intake of fruits and vegetables, and alcohol and tobacco use over an 18-month period. Analyses included generalized linear mixed models and Cox regression survival analyses...
July 5, 2018: Cancer
Marc A Dall'Era, Mary J Lo, Jaclyn Y Chen, Rosemary Cress, Ann S Hamilton
No abstract text is available yet for this article.
July 5, 2018: Cancer
Mosunmoluwa Oyenuga, John K Yang, Anna E Prizment, Sally Bushhouse, Ellen W Demerath, Logan G Spector
BACKGROUND: Minnesota has the second largest Hmong population in the United States. The objective of the current study was to estimate the cancer incidence among Hmong individuals in Minnesota between 2000 and 2012 to determine targets for screening and interventions. METHODS: Cancer cases in Minnesota between 2000 and 2012 were obtained from the Minnesota Cancer Surveillance System, and proportional incidence ratios (PIRs) were calculated. The 2000 and 2010 US Census reports were used to obtain total population estimates...
July 5, 2018: Cancer
Ali A Mokdad, Xian-Jin Xie, Hong Zhu, David E Gerber, Daniel F Heitjan
BACKGROUND: Phase I cancer trials increasingly incorporate dose-expansion cohorts (DECs), reflecting a growing demand to acquire more information about investigational drugs. Protocols commonly fail to provide a sample-size justification or analysis plan for the DEC. In this study, we develop a statistical framework for the design of DECs. METHODS: We assume the maximum tolerated dose (MTD) for the investigational drug has been identified in the dose-escalation stage of the trial...
July 5, 2018: Cancer
Martin T King, Paul L Nguyen, Ninjin Boldbaatar, Clare M Tempany, Robert A Cormack, Clair J Beard, Mark D Hurwitz, W Warren Suh, Anthony V D'Amico, Peter F Orio
BACKGROUND: Partial prostate treatment has emerged as a potential method for treating patients with favorable-risk prostate cancer while minimizing toxicity. The authors previously demonstrated poor rates of biochemical disease control for patients with National Comprehensive Cancer Network (NCCN) intermediate-risk disease using partial gland treatment with brachytherapy. The objective of the current study was to estimate the rates of distant metastasis and prostate cancer-specific mortality (PCSM) for this cohort...
July 5, 2018: Cancer
Chiranjeev Dash, Teletia R Taylor, Kepher H Makambi, Jennifer Hicks, James M Hagberg, Lucile L Adams-Campbell
BACKGROUND: This study examined the effects of supervised and home-based exercise interventions on changes in metabolic syndrome (MetS) according to breast cancer risk (high vs low) in black women enrolled in the Focused Intervention on Exercise to Reduce Cancer (FIERCE) trial. METHODS: Postmenopausal, obese, metabolically unhealthy black women, 45 to 65 years old, were randomized to supervised aerobic exercise (73 women), home-based walking-based exercise (69 women), or a control arm (71 women)...
July 5, 2018: Cancer
Anick Nater, Lindsay A Tetreault, Branko Kopjar, Paul M Arnold, Mark B Dekutoski, Joel A Finkelstein, Charles G Fisher, John C France, Ziya L Gokaslan, Laurence D Rhines, Peter S Rose, Arjun Sahgal, James M Schuster, Alexander R Vaccaro, Michael G Fehlings
BACKGROUND: This study was designed to identify preoperative predictors of survival in surgically treated patients with metastatic epidural spinal cord compression (MESCC), to examine how these predictors are related to 8 prognostic models, and to perform the first full external validation of these models in accordance with the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) statement. METHODS: One hundred forty-two surgically treated patients with MESCC were enrolled in a prospective, multicenter North American cohort study and were followed for 12 months or until death...
July 5, 2018: Cancer
Kelley R Jordan, Brett R Loman, Michael T Bailey, Leah M Pyter
Increasing scientific attention is focused on the gut-brain axis, including the ability of the gastrointestinal (GI) tract to modulate central nervous system function. Changes in the intestinal microbiome can influence affective-like behavior, cognitive performance, fatigue, and sleep in rodents and humans. Patients with cancer who are receiving chemotherapy experience similar negative behavioral changes and concurrent GI symptoms. These chemotherapy comorbidities can be long-lasting and may reduce patients' quality of life and motivation to comply with treatment...
July 5, 2018: Cancer
Todd M Gibson, Chenghong Li, Gregory T Armstrong, Deo Kumar Srivastava, Wendy M Leisenring, Ann Mertens, Tara M Brinkman, Lisa Diller, Paul C Nathan, Melissa M Hudson, Leslie L Robison
BACKGROUND: Survivors of childhood cancer are at significant risk for serious chronic health conditions and subsequent cancers because of their prior treatment exposures. However, little is known about survivors' perceptions of their future health risks. METHODS: This study examined self-reported levels of concern about future health and subsequent cancer in 15,620 adult survivors of childhood cancer (median age, 26 years; median time since diagnosis, 17 years) and 3991 siblings in the Childhood Cancer Survivor Study...
June 25, 2018: Cancer
Jennifer R Bail, Andrew D Frugé, Mallory G Cases, Jennifer F De Los Santos, Julie L Locher, Kerry P Smith, Alan B Cantor, Harvey J Cohen, Wendy Demark-Wahnefried
BACKGROUND: The current study assessed the feasibility of a mentored home-based vegetable gardening intervention and examined changes in health-related outcomes among breast cancer survivors (BCS). METHODS: BCS were randomized to either a year-long vegetable gardening intervention to begin immediately or a wait-list control. Master Gardeners mentored participants in planning, planting, and maintaining 3 seasonal gardens over the course of 1 year. Participant accrual, retention, and satisfaction rates of ≥80% served as feasibility (primary outcome) benchmarks...
June 22, 2018: Cancer
Ryan D Frank, Stacey J Winham, Robert A Vierkant, Marlene H Frost, Derek C Radisky, Karthik Ghosh, Kathleen R Brandt, Mark E Sherman, Daniel W Visscher, Lynn C Hartmann, Amy C Degnim, Celine M Vachon
BACKGROUND: More than 1.5 million women per year have a benign breast biopsy resulting in concern about their future breast cancer (BC) risk. This study examined the performance of 2 BC risk models that integrate clinical and histologic findings in this population. METHODS: The BC risk at 5 and 10 years was estimated with the Breast Cancer Surveillance Consortium (BCSC) and Benign Breast Disease to Breast Cancer (BBD-BC) models for women diagnosed with benign breast disease (BBD) at the Mayo Clinic from 1997 to 2001...
June 22, 2018: Cancer
Evan M Graboyes, Mark A Ellis, Hong Li, John M Kaczmar, Anand K Sharma, Eric J Lentsch, Terry A Day, Chanita Hughes Halbert
BACKGROUND: Patients who travel a long distance (≥50 miles) for cancer care have improved outcomes. However, to the authors' knowledge, the prevalence of long travel distances for treatment by patients with head and neck squamous cell carcinoma (HNSCC), and the effect of travel distance on overall survival (OS), remains unknown. METHODS: The authors used the National Cancer Data base from 2004 through 2013 to identify patients with HNSCC undergoing definitive treatment...
June 22, 2018: Cancer
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