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CA: a Cancer Journal for Clinicians

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https://www.readbyqxmd.com/read/29384589/who-s-still-smoking-disparities-in-adult-cigarette-smoking-prevalence-in-the-united-states
#1
Jeffrey Drope, Alex C Liber, Zachary Cahn, Michal Stoklosa, Rosemary Kennedy, Clifford E Douglas, Rosemarie Henson, Jacqui Drope
The continuing high prevalence of cigarette smoking among specific subpopulations, many of them vulnerable, is one of the most pressing challenges facing the tobacco control community. These populations include individuals in lower education and/or socioeconomic groups; from certain racial/ethnic groups; in the lesbian, gay, bisexual, and transgender community; with mental illness; and in the military, particularly among those in the lowest pay grades. Although traditional tobacco control measures are having positive health effects for most groups, the effects are not sufficient for others...
January 31, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29377070/factors-influencing-risk-based-care-of-the-childhood-cancer-survivor-in-the-21st-century
#2
REVIEW
Stephanie B Dixon, Kari L Bjornard, Nicole M Alberts, Gregory T Armstrong, Tara M Brinkman, Wassim Chemaitilly, Matthew J Ehrhardt, Israel Fernandez-Pineda, Lisa M Force, Todd M Gibson, Daniel M Green, Carrie R Howell, Sue C Kaste, Anne C Kirchhoff, James L Klosky, Kevin R Krull, John T Lucas, Daniel A Mulrooney, Kirsten K Ness, Carmen L Wilson, Yutaka Yasui, Leslie L Robison, Melissa M Hudson
The population of adult survivors of childhood cancer continues to grow as survival rates improve. Although it is well established that these survivors experience various complications and comorbidities related to their malignancy and treatment, this risk is modified by many factors that are not directly linked to their cancer history. Research evaluating the influence of patient-specific demographic and genetic factors, premorbid and comorbid conditions, health behaviors, and aging has identified additional risk factors that influence cancer treatment-related toxicity and possible targets for intervention in this population...
January 29, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29369334/the-incidental-thyroid-nodule
#3
REVIEW
Sarah B Fisher, Nancy D Perrier
Incidental thyroid nodules that are found on an imaging study performed for reasons other than thyroid pathology represent a common scenario encountered by health care providers. The initial workup for these nodules comprises a thorough history and physical examination, thyroid function tests, a dedicated thyroid ultrasound, and fine-needle aspiration of any suspicious lesions. Management ranges from observation and reassurance to surgical resection and depends on the cytologic diagnosis. In cases of cytologically indeterminate or discordant nodules, surgical excision (lobectomy) offers a definitive diagnosis, although molecular testing or a reasonable period of observation may be useful as less invasive adjuncts...
January 25, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29338071/the-financial-burden-and-distress-of-patients-with-cancer-understanding-and-stepping-up-action-on-the-financial-toxicity-of-cancer-treatment
#4
REVIEW
Pricivel M Carrera, Hagop M Kantarjian, Victoria S Blinder
"Financial toxicity" has now become a familiar term used in the discussion of cancer drugs, and it is gaining traction in the literature given the high price of newer classes of therapies. However, as a phenomenon in the contemporary treatment and care of people with cancer, financial toxicity is not fully understood, with the discussion on mitigation mainly geared toward interventions at the health system level. Although important, health policy prescriptions take time before their intended results manifest, if they are implemented at all...
January 16, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29319885/patient-selection-in-major-upper-abdominal-surgery-for-cancer-in-octogenarians
#5
Lara C Pullen
No abstract text is available yet for this article.
January 10, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29319847/decision-making-in-breast-cancer-risk-reduction
#6
Lara C Pullen
No abstract text is available yet for this article.
January 10, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29313949/cancer-statistics-2018
#7
Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data, available through 2014, were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data, available through 2015, were collected by the National Center for Health Statistics...
January 4, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29194581/hodgkin-lymphoma-a-review-and-update-on-recent-progress
#8
REVIEW
Satish Shanbhag, Richard F Ambinder
Hodgkin lymphoma (HL) is a unique hematopoietic neoplasm characterized by cancerous Reed-Sternberg cells in an inflammatory background. Patients are commonly diagnosed with HL in their 20s and 30s, and they present with supradiaphragmatic lymphadenopathy, often with systemic B symptoms. Even in advanced-stage disease, HL is highly curable with combination chemotherapy, radiation, or combined-modality treatment. Although the same doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapeutic regimen has been the mainstay of therapy over the last 30 years, risk-adapted approaches have helped de-escalate therapy in low-risk patients while intensifying treatment for higher risk patients...
December 1, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29165798/weight-management-and-physical-activity-throughout-the-cancer-care-continuum
#9
Wendy Demark-Wahnefried, Kathryn H Schmitz, Catherine M Alfano, Jennifer R Bail, Pamela J Goodwin, Cynthia A Thomson, Don W Bradley, Kerry S Courneya, Christie A Befort, Crystal S Denlinger, Jennifer A Ligibel, William H Dietz, Melinda R Stolley, Melinda L Irwin, Marcas M Bamman, Caroline M Apovian, Bernardine M Pinto, Kathleen Y Wolin, Rachel M Ballard, Andrew J Dannenberg, Elizabeth G Eakin, Matt M Longjohn, Susan D Raffa, Lucile L Adams-Campbell, Joanne S Buzaglo, Sharyl J Nass, Greta M Massetti, Erin P Balogh, Elizabeth S Kraft, Anand K Parekh, Darshak M Sanghavi, G Stephen Morris, Karen Basen-Engquist
Mounting evidence suggests that weight management and physical activity (PA) improve overall health and well being, and reduce the risk of morbidity and mortality among cancer survivors. Although many opportunities exist to include weight management and PA in routine cancer care, several barriers remain. This review summarizes key topics addressed in a recent National Academies of Science, Engineering, and Medicine workshop entitled, "Incorporating Weight Management and Physical Activity Throughout the Cancer Care Continuum...
November 22, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29160902/proportion-and-number-of-cancer-cases-and-deaths-attributable-to-potentially-modifiable-risk-factors-in-the-united-states
#10
Farhad Islami, Ann Goding Sauer, Kimberly D Miller, Rebecca L Siegel, Stacey A Fedewa, Eric J Jacobs, Marjorie L McCullough, Alpa V Patel, Jiemin Ma, Isabelle Soerjomataram, W Dana Flanders, Otis W Brawley, Susan M Gapstur, Ahmedin Jemal
Contemporary information on the fraction of cancers that potentially could be prevented is useful for priority setting in cancer prevention and control. Herein, the authors estimate the proportion and number of invasive cancer cases and deaths, overall (excluding nonmelanoma skin cancers) and for 26 cancer types, in adults aged 30 years and older in the United States in 2014, that were attributable to major, potentially modifiable exposures (cigarette smoking; secondhand smoke; excess body weight; alcohol intake; consumption of red and processed meat; low consumption of fruits/vegetables, dietary fiber, and dietary calcium; physical inactivity; ultraviolet radiation; and 6 cancer-associated infections)...
November 21, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29155450/risk-of-ovarian-function-recovery-should-be-considered-when-switching-from-treatment-with-adjuvant-tamoxifen-to-aromatase-inhibitor-therapy-in-women-with-chemotherapy-induced-amenorrhea
#11
https://www.readbyqxmd.com/read/29155447/older-adults-may-not-consider-life-expectancy-an-important-factor-in-cancer-screening
#12
Clement Chung
No abstract text is available yet for this article.
November 20, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29092098/differentiated-and-anaplastic-thyroid-carcinoma-major-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#13
REVIEW
Nancy D Perrier, James D Brierley, R Michael Tuttle
Answer questions and earn CME/CNE This is a review of the major changes in the American Joint Committee on Cancer staging manual, eighth edition, for differentiated and anaplastic thyroid carcinoma. All patients younger than 55 years have stage I disease unless they have distant metastases, in which case, their disease is stage II. In patients aged 55 years or older, the presence of distant metastases confers stage IVB, while cases without distant metastases are further categorized based on the presence/absence of gross extrathyroidal extension, tumor size, and lymph node status...
November 1, 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29028110/melanoma-staging-evidence-based-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#14
Jeffrey E Gershenwald, Richard A Scolyer, Kenneth R Hess, Vernon K Sondak, Georgina V Long, Merrick I Ross, Alexander J Lazar, Mark B Faries, John M Kirkwood, Grant A McArthur, Lauren E Haydu, Alexander M M Eggermont, Keith T Flaherty, Charles M Balch, John F Thompson
Answer questions and earn CME/CNE To update the melanoma staging system of the American Joint Committee on Cancer (AJCC) a large database was assembled comprising >46,000 patients from 10 centers worldwide with stages I, II, and III melanoma diagnosed since 1998. Based on analyses of this new database, the existing seventh edition AJCC stage IV database, and contemporary clinical trial data, the AJCC Melanoma Expert Panel introduced several important changes to the Tumor, Nodes, Metastasis (TNM) classification and stage grouping criteria...
November 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29023645/higher-cigarette-pricing-encourages-older-smokers-to-quit
#15
Lara C Pullen
No abstract text is available yet for this article.
November 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28972651/breast-cancer-statistics-2017-racial-disparity-in-mortality-by-state
#16
Carol E DeSantis, Jiemin Ma, Ann Goding Sauer, Lisa A Newman, Ahmedin Jemal
In this article, the American Cancer Society provides an overview of female breast cancer statistics in the United States, including data on incidence, mortality, survival, and screening. Approximately 252,710 new cases of invasive breast cancer and 40,610 breast cancer deaths are expected to occur among US women in 2017. From 2005 to 2014, overall breast cancer incidence rates increased among Asian/Pacific Islander (1.7% per year), non-Hispanic black (NHB) (0.4% per year), and Hispanic (0.3% per year) women but were stable in non-Hispanic white (NHW) and American Indian/Alaska Native (AI/AN) women...
November 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28961314/key-issues-surrounding-the-health-impacts-of-electronic-nicotine-delivery-systems-ends-and-other-sources-of-nicotine
#17
REVIEW
Jeffrey Drope, Zachary Cahn, Rosemary Kennedy, Alex C Liber, Michal Stoklosa, Rosemarie Henson, Clifford E Douglas, Jacqui Drope
Answer questions and earn CME/CNE Over the last decade, the use of electronic nicotine delivery systems (ENDS), including the electronic cigarette or e-cigarette, has grown rapidly. More youth now use ENDS than any tobacco product. This extensive research review shows that there are scientifically sound, sometimes competing arguments about ENDS that are not immediately and/or completely resolvable. However, the preponderance of the scientific evidence to date suggests that current-generation ENDS products are demonstrably less harmful than combustible tobacco products such as conventional cigarettes in several key ways, including by generating far lower levels of carcinogens and other toxic compounds than combustible products or those that contain tobacco...
November 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28961310/treatment-of-renal-cell-carcinoma-current-status-and-future-directions
#18
REVIEW
Pedro C Barata, Brian I Rini
Answer questions and earn CME/CNE Over the past 12 years, medical treatment for renal cell carcinoma (RCC) has transitioned from a nonspecific immune approach (in the cytokine era), to targeted therapy against vascular endothelial growth factor (VEGF), and now to novel immunotherapy agents. Multiple agents-including molecules against vascular endothelial growth factor, platelet-derived growth factor, and related receptors; inhibitors of other targets, such as the mammalian target of rapamycin and the MET and AXL tyrosine-protein kinase receptors; and an immune-checkpoint inhibitor-have been approved based on significant activity in patients with advanced RCC...
November 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28914965/reviewer-acknowledgment-2017
#19
(no author information available yet)
No abstract text is available yet for this article.
November 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28881380/missed-therapeutic-and-prevention-opportunities-in-women-with-brca-mutated-epithelial-ovarian-cancer-and-their-families-due-to-low-referral-rates-for-genetic-counseling-and-brca-testing-a-review-of-the-literature
#20
REVIEW
Paul J Hoskins, Walter H Gotlieb
Answer questions and earn CME/CNE Fifteen percent of women with epithelial ovarian cancer have inherited mutations in the BRCA breast cancer susceptibility genes. Knowledge of her BRCA status has value both for the woman and for her family. A therapeutic benefit exists for the woman with cancer, because a new family of oral drugs, the poly ADP-ribose polymerase (PARP) inhibitors, has recently been approved, and these drugs have the greatest efficacy in women who carry the mutation. For her family, there is the potential to prevent ovarian cancer in those carrying the mutation by using risk-reducing surgery...
November 2017: CA: a Cancer Journal for Clinicians
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