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Brain Injury: [BI]

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https://www.readbyqxmd.com/read/29345501/-it-s-nothing-you-could-ever-prepare-anyone-for-the-experiences-of-young-people-and-their-families-following-parental-stroke
#1
Clare Coppock, Scott Ferguson, Anna Green, David Winter
AIMS: This study sought to explore the experiences of young people (aged 8-16) and their families following parental acquired brain injury (ABI), with the aim of developing an understanding of the ways in which members of a family make sense of events post-injury, and to consider the implications of different perspectives on adjustment and coping. DESIGN: The study applied a qualitative approach using a thematic analysis methodology. PROCEDURE: Individual semi-structured interviews were conducted with 10 individuals from three families affected by parental stroke...
January 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29341793/platelet-transfusion-does-not-improve-outcomes-in-patients-with-brain-injury-on-antiplatelet-therapy
#2
Jeremy L Holzmacher, Cassandra Reynolds, Mayur Patel, Patrick Maluso, Seth Holland, Nathaniel Gamsky, Henry Moore, Elizabeth Acquista, Matthew Carrick, Richard Amdur, Heather Hancock, Michael Metzler, Julie Dunn, Babak Sarani
INTRODUCTION: Platelet dysfunction following traumatic brain injury (TBI) is associated with worse outcomes. The efficacy of platelet transfusion to reverse antiplatelet medication (APM) remains unknown. Thrombelastography platelet mapping (TEG-PM) assesses platelet function. We hypothesize that platelet transfusion can reverse the effects of APM but does not improve outcomes following TBI. METHODS: An observational study at six US trauma centres was performed. Adult patients on APM with CT evident TBI after blunt injury were enrolled...
January 17, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29341786/unscheduled-adolescents-return-to-the-emergency-department-following-acute-concussion
#3
Dana Baron Shahaf, Sapir Bar, Ronit Leiba, Vered Dvir, Itai Shavit
OBJECTIVE: Emergency department (ED) visits due to concussion have increased over recent years. We aimed to identify variables associated with unscheduled adolescents return to the ED. METHODS: A retrospective cohort study was conducted. All children aged 11 to 18 years who were admitted to the ED due to concussion between 2011 and 2016 were included. Multivariable logistic regression was performed to identify predictors of ED return. RESULTS: Overall, 616 adolescents were admitted to the ED due to concussion...
January 17, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29333886/anaemia-worsens-early-functional-outcome-after-traumatic-brain-injury-a-preliminary-study
#4
N Scott Litofsky, Douglas C Miller, Zhenzhou Chen, Agnes Simonyi, Diana Klakotskaia, Andrew Giritharan, Qi Feng, Diane McConnell, Jiankun Cui, Zezong Gu
OBJECTIVE: To determine early effects on outcome from traumatic brain injury (TBI) induced by controlled cortical impact (CCI) associated with anaemia in mice. HYPOTHESIS: Outcome from TBI with concomitant anaemia would be worse than TBI without anaemia. METHODS: CCI was induced with electromagnetic impaction in four groups of C57BL/6J mice: sham, sham+anaemia; TBI; and TBI+anaemia. Anaemia was created by withdrawal of 30% of calculated intravascular blood volume and saline replacement of equal volume...
January 15, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29283288/a-novel-method-for-the-rapid-detection-of-post-translationally-modified-visinin-like-protein-1-in-rat-models-of-brain-injury
#5
Melissa A Bradley-Whitman, Kelly N Roberts, Erin L Abner, Stephen W Scheff, Bert C Lynn, Mark A Lovell
BACKGROUND: Although elevated serum levels of visinin-like protein 1 (VILIP-1), a neuron-specific calcium sensor protein, are associated with ischaemic stroke, only a single study has evaluated VILIP-1 as a biomarker of traumatic brain injury (TBI). The current proof-of-concept study was designed to determine whether serum VILIP-1 levels increase post-injury in a well-characterized rat unilateral cortical contusion model. METHODS: Lateral flow devices (LFDs) rapidly (< 20 min) detected trace serum levels (pg/mL) of VILIP-1 in a small input sample volume (10 µL)...
December 28, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29283287/hypopituitarism-3-and-12-months-after-traumatic-brain-injury-and-subarachnoid-haemorrhage
#6
Asta Dogg Jonasdottir, Petur Sigurjonsson, Ingvar Hakon Olafsson, Sigurbergur Karason, Gudmundur Sigthorsson, Helga Agusta Sigurjonsdottir
OBJECTIVE: High prevalence of hypopituitarism (HP) has been reported after traumatic brain injury (TBI) and subarachnoid haemorrhage (SAH). The aim of the study was to prospectively evaluate the prevalence and progression of HP in patients after TBI and SAH in Icelandic population. DESIGN: A 12 month prospective single-centre study. METHODS AND PROCEDURES: A total of 27 patients were included, 15 patients with TBI and 12 patients with SAH...
December 28, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29283285/the-therapeutic-value-of-cranioplasty-in-individuals-with-brain-injury
#7
Neil Jasey, Irene Ward, Anthony Lequerica, Nancy D Chiaravalloti
PRIMARY OBJECTIVE: To examine the effect of cranioplasty on recovery. RESEARCH DESIGN: Retrospective cohort study. METHOD AND PROCEDURES: Retrospective chart review conducted in 2011 and 2012 on adult inpatients with craniectomy who completed a continuous episode of inpatient rehabilitation before and after receiving their cranioplasty. Patients were matched 1:1 or age, gender, functional level at admission, injury severity and length of stay with inpatients who completed rehabilitation before cranioplasty...
December 28, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29283279/virtual-peer-delivered-memory-intervention-a-single-case-experimental-design-in-an-adolescent-with-chronic-memory-impairment
#8
Janine M Cooper, Stephen Lockett, Alissandra McIlroy, Linda Gonzalez
BACKGROUND: Children and adolescents with chronic memory impairment may develop coping strategies that enable functioning, yet these often remain undetectable using traditional psychometric measures. Personalized intervention studies that promote the use of such strategies designed specifically for use by this young cohort are scarce. OBJECTIVE: To investigate the effect of a novel virtual reality peer-delivered memory intervention on the everyday functioning and well-being of SE, a 17-year-old female with a history of chronic verbal memory issues, impaired autobiographical event recall and elevated mood symptoms...
December 28, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29278927/time-since-injury-limits-but-does-not-prevent-improvement-and-maintenance-of-gains-in-balance-in-chronic-stroke
#9
Roberto Llorens, Enrique Noé, Mariano Alcañiz, Judith E Deutsch
OBJECTIVE: To determine the influence of time since injury on the efficacy and maintenance of gains of rehabilitation of balance after stroke. METHOD: Forty-seven participants were assigned to a least (6-12 months), a moderate (12-24 months), or a most chronic (>24 months) group. Participants trained for 20 one-hour sessions, administered three to five times a week, combining conventional physical therapy and visual feedback-based exercises that trained the ankle and hip strategies...
December 26, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29265938/vegetative-state-outcomes-improved-over-the-last-two-decades
#10
Elena Aidinoff, Zeev Groswasser, Uri Bierman, Ilana Gelernter, Amiram Catz, Rotem Gur-Pollack
OBJECTIVE: To describe late outcomes in patients with prolonged unawareness, and factors affecting them. DESIGN: A retrospective study of 154 patients with traumatic brain injury (TBI) and 52 with non-traumatic brain injury (NTBI), admitted for intensive care and consciousness rehabilitation (ICCR), in a vegetative state (VS) lasting over 1 month. RESULTS: Survival rate (67% total) was higher than in past studies carried out at the same facility (p < 0...
December 21, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29227174/gambogic-amide-a-selective-trka-agonist-does-not-improve-outcomes-from-traumatic-brain-injury-in-mice
#11
Maddison R Johnstone, Mujun Sun, Caroline J Taylor, Rhys D Brady, Brian L Grills, Jarrod E Church, Sandy R Shultz, Stuart J McDonald
OBJECTIVES: There is evidence that treatment with nerve growth factor (NGF) may reduce neuroinflammation and apoptosis after a traumatic brain injury (TBI). NGF is thought to exert its effects via binding to either TrkA or p75 neurotrophin receptors. This study aimed to investigate the effects of a selective TrkA agonist, gambogic amide (GA), on TBI pathology and outcomes in mice following lateral fluid percussion injury. METHODS: Male C57BL/6 mice were given either a TBI or sham injury, and then received subcutaneous injections of either 2 mg/kg of GA or vehicle at 1, 24, and 48 h post-injury...
December 11, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29215914/feasibility-and-effectiveness-of-a-parenting-programme-for-mexican-parents-of-children-with-acquired-brain-injury-case-report
#12
Clara Chavez-Arana, Cathy Catroppa, Guillermina Yáñez Téllez, Celia Godfrey, Belén Prieto-Corona, Miguel A de León, Antonio García, Vicki Anderson
BACKGROUND: Acquired brain injury (ABI) during childhood typically causes behaviour problems in the child and high levels of stress in the family. OBJECTIVES: (1) To investigate the feasibility and effectiveness of a parenting programme to: improve behaviour and self-regulation (SR) in Mexican children with ABI, enhance parenting skills, and decrease parental stress in parents of children with ABI; (2) to explore the impact of parent SR on child. METHODS: Case study design with four participants post-ABI, aged 7-12 years, recruited in Mexico City...
December 7, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29211506/validity-of-low-resolution-eye-tracking-to-assess-eye-movements-during-a-rapid-number-naming-task-performance-of-the-eyetribe-eye-tracker
#13
Jenelle Raynowska, John-Ross Rizzo, Janet C Rucker, Weiwei Dai, Joel Birkemeier, Julian Hershowitz, Ivan Selesnick, Laura J Balcer, Steven L Galetta, Todd Hudson
OBJECTIVE: To evaluate the performance of the EyeTribe compared to the EyeLink for eye movement recordings during a rapid number naming test in healthy control participants. BACKGROUND: With the increasing accessibility of portable, economical, video-based eye trackers such as the EyeTribe, there is growing interest in these devices for eye movement recordings, particularly in the domain of sports-related concussion. However, prior to implementation there is a primary need to establish the validity of these devices...
December 6, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29211502/physical-activity-perceptions-of-people-with-severe-traumatic-brain-injury-living-in-the-community
#14
Penelope Analytis, Adam McKay, Megan Hamilton, Gavin Williams, Narelle Warren, Jennie Ponsford
PRIMARY OBJECTIVE: Increasing physical activity (PA) among people with severe traumatic brain injury (TBI) represents an important long-term rehabilitation goal. To design effective interventions to promote PA, the factors associated with PA engagement post-TBI need to be understood. RESEARCH DESIGN: A qualitative study design was employed to investigate the factors influencing PA engagement in people with severe TBI living in the community. METHODS AND PROCEDURES: Face-to-face interviews were conducted with eight people with severe TBI three to five years post-injury...
December 6, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29206059/efficacy-of-an-intervention-programme-for-rehabilitation-of-awareness-of-deficit-after-acquired-brain-injury-a-pilot-study
#15
Dolores Villalobos, Álvaro Bilbao, Alfonso Espejo, Javier García-Pacios
BACKGROUND: Impaired Awareness of Deficit (AD) is a frequent symptom after suffering acquired brain injury (ABI) that severely influences patients' daily lives. PRIMARY OBJECTIVE: Pilot study to assess the effectiveness of a structured intervention programme which was developed from a biopsychosocial approach, and relied on common therapeutic strategies of proven effectiveness. METHODS: We assessed the effectiveness of our intervention on a sample of 60 patients with ABI, 30 of whom received the specific AD intervention programme, while the other 30 followed an equivalent rehabilitation approach where they received no specific intervention on AD...
December 5, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29200309/survival-and-mortality-following-tbi
#16
Zeev Groswasser, Israela Peled
OBJECTIVES: Evaluation of life expectancy (LE) post traumatic brain injury (TBI) is important for planning services for patients and for dealing with medico-legal aspects. We hypothesized that LE for patients who survived 2 years post injury is equal to that of the general population (GP). METHODS: A cohort of 279 patients was assembled during a 5-year period and was followed for 22-27 years. During follow-up, 32 patients (11.5%) died, creating a huge censored data (88...
December 4, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29190189/changes-in-working-memory-performance-in-youth-following-concussion
#17
Stephanie L Green, Michelle L Keightley, Nancy J Lobaugh, Deirdre R Dawson, Alex Mihailidis
OBJECTIVE: The purpose of this study was to compare the working memory (WM) performance pre- and post-concussion, and investigate the relationships between performance changes and characteristics such as self-reported symptom scores, number of days post-injury and age at injury in 10-14-year-old youth. METHODS: Twenty-one youth (17 males) aged 10-14 years recruited from the community completed verbal and non-verbal WM tasks pre- and post-concussion. Performance was measured using accuracy and performance errors (false alarms and misses)...
November 30, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29190153/cognitive-function-and-participation-in-children-and-youth-with-mild-traumatic-brain-injury-two-years-after-injury
#18
S A M Lambregts, J E M Smetsers, I M A J Verhoeven, A J de Kloet, I G L van de Port, G M Ribbers, C E Catsman-Berrevoets
BACKGROUND: 10-20% of children and youth with mild traumatic brain injury (mTBI) suffer from long-term cognitive impairments with, supposedly, a negative impact on most domains of functioning. OBJECTIVES: To describe cognitive functioning and participation in children and youth two-years post-mTBI and to determine associated risk factors. METHODS: Cross-sectional study among 73 patients (aged 6-22 years), hospital diagnosed with mTBI. Linear regression modelling was used to investigate the effect of potential predictors on cognitive functioning as measured with a neuropsychological assessment (NPA), two-years post-injury...
November 30, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29190150/intravenous-saline-administration-in-patients-with-severe-acquired-brain-injury-and-orthostatic-intolerance-for-tilt-table-mobilization
#19
Christian Riberholt, Niels Olesen, Peter Hovind, Jesper Mehlsen, Tue Hvass Petersen
PRIMARY OBJECTIVE: This study aimed to investigate the effect of intravenous saline administration on orthostatic hypotension (OH) during head up tilt (HUT) and the change in the renin-angiotensin-aldosterone system before and after HUT in patients with severe acquired brain injury (ABI). RESEARCH DESIGN: The study is designed as an observational study. METHODS AND PROCEDURES: Fourteen patients with ABI, low level of consciousness and OH were monitored before, during and after HUT with non-invasive beat-to-beat blood pressure measurement, and transcranial Doppler determination of middle cerebral artery blood flow velocity...
November 30, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29190146/prevalence-of-depression-after-tbi-in-a-prospective-cohort-the-shefbit-study
#20
Rajiv Singh, Suzanne Mason, Fiona Lecky, Jeremy Dawson
OBJECTIVE: The objective is to measure the prevalence of depression after traumatic brain injury (TBI) and the features associated with increased risk in a cohort that reflects clinical practice. METHODS: Prospective TBI admissions to a large Teaching Hospital Emergency Department were recruited over a 2-year period. Assessments for depression and other psychosocial and global outcomes were completed at 3 months post-injury. Comparisons were made with demographic and injury features of interest to establish any associations of depression risk...
November 30, 2017: Brain Injury: [BI]
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