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British Journal of Surgery

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https://www.readbyqxmd.com/read/28542731/systematic-review-of-the-influence-of-chemotherapy-associated-liver-injury-on-outcome-after-partial-hepatectomy-for-colorectal-liver-metastases
#1
REVIEW
J Zhao, K M C van Mierlo, J Gómez-Ramírez, H Kim, C H C Pilgrim, P Pessaux, S S Rensen, E P van der Stok, F G Schaap, O Soubrane, T Takamoto, L Viganò, B Winkens, C H C Dejong, S W M Olde Damink
BACKGROUND: The impact of chemotherapy-associated liver injury (CALI) on postoperative outcome in patients undergoing partial hepatectomy for colorectal liver metastases (CRLM) remains controversial. The objective of this study was to clarify the effect of CALI (sinusoidal dilatation (SD), steatosis and steatohepatitis) on postoperative morbidity and mortality by investigating a large data set from multiple international centres. METHODS: PubMed and Embase were searched for studies published between 1 January 2004 and 31 December 2013 with keywords 'chemotherapy', 'liver resection', 'outcome' and 'colorectal metastases' to identify potential collaborating centres...
May 25, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28542986/tryptase-expression-as-a-prognostic-marker-in-patients-with-resected-gastric-cancer
#2
C Lin, H Liu, H Zhang, Y Cao, R Li, S Wu, H Li, H He, J Xu, Y Sun
BACKGROUND: Mast cells play important roles in the progression of various malignancies, but their prognostic value in gastric cancer is unknown. Tryptase expression, as an indicator of mast cell activity, was therefore evaluated to see whether this could be incorporated usefully into a prognostic nomogram after surgery in patients with gastric cancer. METHODS: Tissue microarrays from patients with gastric cancer were created from formalin-fixed, paraffin-embedded resection specimens...
May 24, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28542954/population-based-study-to-re-evaluate-optimal-lymph-node-yield-in-colonic-cancer
#3
J C Del Paggio, Y Peng, X Wei, S Nanji, P H MacDonald, C Krishnan Nair, C M Booth
BACKGROUND: It is well established that lymph node (LN) yield in colonic cancer resection has prognostic significance, although optimal numbers are not clear. Here, LN thresholds associated with both LN positivity and survival were evaluated in a single population-based data set. METHODS: Treatment records were linked to the Ontario Cancer Registry to identify a 25 per cent random sample of all patients with stage II/III colonic cancer between 2002 and 2008. Multivariable regression and Cox models evaluated factors associated with LN positivity and cancer-specific survival (CSS) respectively...
May 24, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28524246/combined-pet-ct-and-axillary-lymph-node-marking-with-radioactive-iodine-seeds-mari-procedure-for-tailored-axillary-treatment-in-node-positive-breast-cancer-after-neoadjuvant-therapy
#4
B B Koolen, M Donker, M E Straver, M E M van der Noordaa, E J T Rutgers, R A Valdés Olmos, M J T F D Vrancken Peeters
BACKGROUND: The treatment of axillary lymph node metastases after neoadjuvant systemic therapy (NST) remains debatable and axillary lymph node dissection (ALND) is still the standard of care. Marking axillary lymph nodes with radioactive iodine seeds (MARI procedure) is accurate in restaging the axilla after NST (false-negative rate 7 per cent). Here, the potential of tailored axillary treatment, determined by combining the results of PET-CT before NST with those of the MARI procedure after NST, was analysed...
May 19, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28517236/effect-of-centralization-on-long-term-survival-after-resection-of-pancreatic-ductal-adenocarcinoma
#5
R Ahola, A Siiki, K Vasama, M Vornanen, J Sand, J Laukkarinen
BACKGROUND: Centralization of pancreatic surgery has resulted in improved short-term outcomes in a number of healthcare systems. The aim of this study was to see whether hospital volume influenced long-term prognosis, use of adjuvant therapy or histopathological evaluation of patients undergoing surgical resection for pancreatic ductal adenocarcinoma (PDAC). METHODS: Patients undergoing surgical resection of PDAC in Finland between 2002 and 2008 were identified from national registers...
May 18, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28493483/preoperative-imaging-and-prediction-of-oesophageal-conduit-necrosis-after-oesophagectomy-for-cancer
#6
P Lainas, D Fuks, S Gaujoux, Z Machroub, A Fregeville, T Perniceni, F Mal, B Dousset, B Gayet
BACKGROUND: Oesophageal conduit necrosis following oesophagectomy is a rare but life-threatening complication. The present study aimed to assess the impact of coeliac axis stenosis on outcomes after oesophagectomy for cancer. METHODS: The study included consecutive patients who had an Ivor Lewis procedure with curative intent for middle- and lower-third oesophageal cancer at two tertiary referral centres. All patients underwent preoperative multidetector CT with arterial phase to detect coeliac axis stenosis...
May 11, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28489253/randomized-clinical-trial-comparing-collagen-plug-and-advancement-flap-for-trans-sphincteric-anal-fistula
#7
J Bondi, J Avdagic, U Karlbom, O Hallböök, D Kalman, J Šaltytė Benth, N Naimy, T Øresland
BACKGROUND: The role of a collagen plug for treating anal fistula is not well established. A randomized prospective multicentre non-inferiority study of surgical treatment of trans-sphincteric cryptogenic fistulas was undertaken, comparing the anal fistula plug with the mucosal advancement flap with regard to fistula recurrence rate and functional outcome. METHODS: Patients with an anal fistula were evaluated for eligibility in three centres, and randomized to either mucosal advancement flap surgery or collagen plug, with clinical follow-up at 3 and 12 months...
May 10, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28489249/validation-of-two-prognostic-models-for-recurrence-and-survival-after-radical-gastrectomy-for-gastric-cancer
#8
M Bencivenga, G Verlato, D-S Han, D Marrelli, F Roviello, H-K Yang, G de Manzoni
BACKGROUND: Prognostic models from Korea and Italy have been developed that predict overall survival and cancer recurrence respectively after radical gastrectomy for gastric cancer. The aim of this study was to validate the two models in independent patient cohorts, and to evaluate which factors may explain differences in prognosis between Korean and Italian patients with gastric cancer. METHODS: Patients who underwent radical gastrectomy for gastric cancer between January 2000 and December 2004 at Seoul National University Hospital and at eight centres in Italy were included...
May 10, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28488801/measuring-and-achieving-the-best-possible-outcomes-in-surgery
#9
P-A Clavien, M A Puhan
No abstract text is available yet for this article.
May 10, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28488733/surgical-resection-for-bismuth-type-iv-perihilar-cholangiocarcinoma
#10
T Ebata, T Mizuno, Y Yokoyama, T Igami, G Sugawara, M Nagino
BACKGROUND: Bismuth type IV perihilar cholangiocarcinoma has traditionally been categorized as unresectable disease. The aim of this study was to review experience with a resection-based strategy in patients who have type IV perihilar cholangiocarcinoma. METHODS: Medical records of consecutive patients with a diagnosis of type IV perihilar cholangiocarcinoma between 2006 and 2015 were reviewed retrospectively. Primary outcomes assessed were surgical results and long-term survival...
May 10, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28488729/randomized-clinical-trial-of-biodegradeable-intraluminal-sheath-to-prevent-anastomotic-leak-after-stapled-colorectal-anastomosis
#11
I S Bakker, A N Morks, H O Ten Cate Hoedemaker, J G M Burgerhof, H G Leuvenink, J B van Praagh, R J Ploeg, K Havenga
BACKGROUND: Anastomotic leakage is a potential major complication after colorectal surgery. The C-seal was developed to help reduce the clinical leakage rate. It is an intraluminal sheath that is stapled proximal to a colorectal anastomosis, covering it intraluminally and thus preventing intestinal leakage in case of anastomotic dehiscence. The C-seal trial was initiated to evaluate the efficacy of the C-seal in reducing anastomotic leakage in stapled colorectal anastomoses. METHODS: This RCT was performed in 41 hospitals in the Netherlands, Germany, France, Hungary and Spain...
May 10, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28480964/survival-benefit-of-liver-resection-for-barcelona-clinic-liver-cancer-stage-b-hepatocellular-carcinoma
#12
H Kim, S W Ahn, S K Hong, K C Yoon, H-S Kim, Y R Choi, H W Lee, N-J Yi, K-W Lee, K-S Suh
BACKGROUND: Although transarterial chemoembolization is recommended as the standard treatment for Barcelona Clinic Liver Cancer stage B hepatocellular carcinoma (BCLC-B HCC), other treatments including liver resection have been used. This study aimed to determine the survival benefit of treatment strategies including resection for BCLC-B HCC compared with non-surgical treatments. METHODS: The nationwide multicentre database of the Korean Liver Cancer Association was reviewed...
May 8, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28449182/validation-of-a-nomogram-for-selecting-patients-for-chemotherapy-after-d2-gastrectomy-for-cancer
#13
Z-X Wang, G-X Li, Z-W Zhou, Z-P Huang, F Wang, R-H Xu
BACKGROUND: According to some guidelines for the management of gastric cancer, adjuvant chemotherapy is recommended for patients with pT3-4 or node-positive disease. The aim of this study was to define low- and high-risk groups in terms of survival, and to predict the benefit of adjuvant fluoropyrimidine plus oxaliplatin (F-OX) chemotherapy. METHODS: Patients with pT3-4 or node-positive gastric cancer after gastrectomy with D2 lymphadenectomy between 2000 and 2013 were included...
April 27, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28444964/randomized-clinical-trial-of-landiolol-hydrochloride-for-the-prevention-of-atrial-fibrillation-and-postoperative-complications-after-oesophagectomy-for-cancer
#14
T Ojima, M Nakamori, M Nakamura, M Katsuda, K Hayata, T Kato, J Kitadani, H Tabata, A Takeuchi, H Yamaue
BACKGROUND: Atrial fibrillation is common after oesophageal surgery. The aim of this study was to evaluate whether landiolol hydrochloride was effective and safe in the prevention of atrial fibrillation after oesophagectomy, and to see whether a reduction in incidence of atrial fibrillation would reduce other postoperative complications. METHODS: This single-centre study enrolled patients scheduled for transthoracic oesophagectomy in a randomized, double-blind, placebo-controlled trial between March 2013 and January 2016...
April 26, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28436602/accuracy-of-circulating-histones-in-predicting-persistent-organ-failure-and-mortality-in-patients-with-acute-pancreatitis
#15
T Liu, W Huang, P Szatmary, S T Abrams, Y Alhamdi, Z Lin, W Greenhalf, G Wang, R Sutton, C H Toh
BACKGROUND: Early prediction of acute pancreatitis severity remains a challenge. Circulating levels of histones are raised early in mouse models and correlate with disease severity. It was hypothesized that circulating histones predict persistent organ failure in patients with acute pancreatitis. METHODS: Consecutive patients with acute pancreatitis fulfilling inclusion criteria admitted to Royal Liverpool University Hospital were enrolled prospectively between June 2010 and March 2014...
April 24, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28425560/impact-of-simulated-three-dimensional-perception-on-precision-of-depth-judgements-technical-performance-and-perceived-workload-in-laparoscopy
#16
S Sakata, P M Grove, A Hill, M O Watson, A R L Stevenson
BACKGROUND: This study compared precision of depth judgements, technical performance and workload using two-dimensional (2D) and three-dimensional (3D) laparoscopic displays across different viewing distances. It also compared the accuracy of 3D displays with natural viewing, along with the relationship between stereoacuity and 3D laparoscopic performance. METHODS: A counterbalanced within-subjects design with random assignment to testing sequences was used. The system could display 2D or 3D images with the same set-up...
April 20, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28401542/quality-of-life-after-mastectomy-with-or-without-immediate-breast-reconstruction
#17
J Dauplat, F Kwiatkowski, P Rouanet, E Delay, K Clough, J L Verhaeghe, I Raoust, G Houvenaeghel, P Lemasurier, E Thivat, C Pomel
BACKGROUND: Mastectomy with immediate breast reconstruction (IBR) is a surgical strategy in breast cancer when breast-conserving surgery is not an option. There is a lack of evidence showing an advantage of mastectomy plus IBR over mastectomy alone on health-related quality of life (QoL). METHODS: A large prospective multicentre survey, STIC-RMI (support of innovative and expensive techniques - immediate breast reconstruction), was undertaken to study the changes in QoL in patients treated by mastectomy with or without IBR...
April 12, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28401534/competing-risks-analysis-of-microsatellite-instability-as-a-prognostic-factor-in-colorectal-cancer
#18
J Toh, P H Chapuis, L Bokey, C Chan, K J Spring, O F Dent
BACKGROUND: Despite an extensive literature suggesting that high microsatellite instability (MSI-H) enhances survival and protects against recurrence after colorectal cancer resection, such effects remain controversial as many studies show only a weak bivariate association or no multivariable association with outcome. This study examined the relationship between MSI status and colorectal cancer outcomes with adjustment for death from other causes as a competing risk. METHODS: A hospital database of patients following colorectal cancer resection was interrogated for clinical, operative, pathology, adjuvant therapy and follow-up information...
April 12, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28401533/long-term-follow-up-of-fenestrated-endovascular-repair-for-juxtarenal-aortic-aneurysm
#19
I N Roy, A M Millen, S M Jones, S R Vallabhaneni, J R H Scurr, R G McWilliams, J A Brennan, R K Fisher
BACKGROUND: Fenestrated endovascular aneurysm repair (FEVAR) is increasingly being used for juxtarenal aortic aneurysms. The aim of this study was to review long-term results and assess the importance of changing stent-graft design on outcomes. METHODS: This was a retrospective review of all patients who underwent FEVAR within a single unit over 12 years (February 2003 to December 2015). Kaplan-Meier analysis of survival, and freedom from target vessel loss, aneurysm expansion, graft-related endoleak and secondary intervention was performed...
April 12, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28394402/dual-hypothermic-oxygenated-machine-perfusion-in-liver-transplants-donated-after-circulatory-death
#20
R van Rijn, N Karimian, A P M Matton, L C Burlage, A C Westerkamp, A P van den Berg, R H J de Kleine, M T de Boer, T Lisman, R J Porte
BACKGROUND: Experimental studies have suggested that end-ischaemic dual hypothermic oxygenated machine perfusion (DHOPE) may restore hepatocellular energy status and reduce reperfusion injury in donation after circulatory death (DCD) liver grafts. The aim of this prospective case-control study was to assess the safety and feasibility of DHOPE in DCD liver transplantation. METHODS: In consecutive DCD liver transplantations, liver grafts were treated with end-ischaemic DHOPE...
April 10, 2017: British Journal of Surgery
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