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British Journal of Surgery

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https://www.readbyqxmd.com/read/29315509/carotid-plaque-volume-in-patients-undergoing-carotid-endarterectomy
#1
S Ball, S Rogers, K Kanesalingam, R Taylor, E Katsogridakis, C McCollum
BACKGROUND: The main indication for carotid endarterectomy (CEA) is severity of carotid artery stenosis, even though most strokes in carotid disease are embolic. The relationship between carotid plaque volume (CPV) and symptoms of cerebral ischaemia, and the measurement of CPV by minimally invasive tomographic ultrasound imaging, were investigated. METHODS: The volume of the endarterectomy specimen was measured using a validated saline suspension technique in patients undergoing CEA...
January 8, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29227530/systematic-review-and-network-meta-analysis-of-methods-of-mesh-fixation-during-laparoscopic-ventral-hernia-repair
#2
REVIEW
J J Baker, S Öberg, K Andresen, T W Klausen, J Rosenberg
BACKGROUND: Ventral hernia repairs are common and have high recurrence rates. They are usually repaired laparoscopically with an intraperitoneal mesh, which can be fixed in various ways. The aim was to evaluate the recurrence rates for the different fixation techniques. METHODS: This systematic review included studies with human adults with a ventral hernia repaired with an intraperitoneal onlay mesh. The outcome was recurrence at least 6 months after operation...
December 11, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29210064/normothermic-machine-perfusion-for-the-assessment-and-transplantation-of-declined-human-kidneys-from-donation-after-circulatory-death-donors
#3
S A Hosgood, E Thompson, T Moore, C H Wilson, M L Nicholson
BACKGROUND: A significant proportion of donation after circulatory death (DCD) kidneys are declined for transplantation because of concerns over their quality. Ex vivo normothermic machine perfusion (NMP) provides a unique opportunity to assess the quality of a kidney and determine its suitability for transplantation. METHODS: In phase 1 of this study, declined human DCD kidneys underwent NMP assessment for 60 min. Kidneys were graded 1-5 using a quality assessment score (QAS) based on macroscopic perfusion, renal blood flow and urine output during NMP...
December 6, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29205297/meta-analysis-of-the-procedural-risks-of-carotid-endarterectomy-and-carotid-artery-stenting-over-time
#4
REVIEW
K Lokuge, D D de Waard, A Halliday, A Gray, R Bulbulia, B Mihaylova
BACKGROUND: Stroke/death rates within 30 days of carotid endarterectomy (CEA) and carotid artery stenting (CAS) in RCTs inform current clinical guidelines. However, the risks may have changed in recent years with wider use of effective stroke prevention therapies, especially statins, improved patient selection and growing operator expertise. The aim of this study was to investigate whether the procedural stroke/death risks from CEA and CAS have changed over time. METHODS: MEDLINE and Embase were searched systematically from inception to May 2016 for observational cohort studies of CEA and CAS...
December 4, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29193022/experimental-study-of-delivery-of-humidified-warm-carbon-dioxide-during-open-abdominal-surgery
#5
S Carpinteri, S Sampurno, J Malaterre, R Millen, M Dean, J Kong, T Chittleborough, A Heriot, A C Lynch, R G Ramsay
BACKGROUND: The aim of this study was to monitor the effect of humidified-warm carbon dioxide (HWCO2 ) delivered into the open abdomen of mice, simulating laparotomy. METHODS: Mice were anaesthetized, ventilated and subjected to an abdominal incision followed by wound retraction. In the experimental group, a diffuser device was used to deliver HWCO2 ; the control group was exposed to passive air flow. In each group of mice, surgical damage was produced on one side of the peritoneal wall...
November 28, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29193010/early-versus-late-recurrence-of-intrahepatic-cholangiocarcinoma-after-resection-with-curative-intent
#6
X-F Zhang, E W Beal, F Bagante, J Chakedis, M Weiss, I Popescu, H P Marques, L Aldrighetti, S K Maithel, C Pulitano, T W Bauer, F Shen, G A Poultsides, O Soubrane, G Martel, B G Koerkamp, E Itaru, T M Pawlik
BACKGROUND: The objective of this study was to investigate the characteristics, treatment and prognosis of early versus late recurrence of intrahepatic cholangiocarcinoma (ICC) after hepatic resection. METHODS: Patients who underwent resection with curative intent for ICC were identified from a multi-institutional database. Data on clinicopathological characteristics, initial operative details, timing and sites of recurrence, recurrence management and long-term outcomes were analysed...
November 28, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29193008/comparison-of-gaze-behaviour-of-trainee-and-experienced-surgeons-during-laparoscopic-gastric-bypass
#7
S Erridge, H Ashraf, S Purkayastha, A Darzi, M H Sodergren
BACKGROUND: Eye tracking presents a novel tool that could be used to profile skill levels in surgery objectively. The primary aim of this study was to identify differences in gaze behaviour between expert and junior surgeons performing a laparoscopic Roux-en-Y gastric bypass (LRYGB) for obesity. METHODS: This prospective observational study used a lightweight eye-tracking apparatus to determine the difference in gaze behaviours between expert (more than 75 procedures) and junior (75 or fewer procedures) surgeons at defined stages of LRYGB...
November 28, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29168881/quality-of-life-in-a-randomized-trial-of-early-closure-of-temporary-ileostomy-after-rectal-resection-for-cancer-easy-trial
#8
J Park, A K Danielsen, E Angenete, D Bock, A C Marinez, E Haglind, J E Jansen, S Skullman, A Wedin, J Rosenberg
BACKGROUND: A temporary ileostomy may reduce symptoms from anastomotic leakage after rectal cancer resection. Earlier results of the EASY trial showed that early closure of the temporary ileostomy was associated with significantly fewer postoperative complications. The aim of the present study was to compare health-related quality of life (HRQOL) following early versus late closure of a temporary ileostomy. METHODS: Early closure of a temporary ileostomy (at 8-13 days) was compared with late closure (at more than 12 weeks) in a multicentre RCT (EASY) that included patients who underwent rectal resection for cancer...
November 23, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29168565/growth-rates-of-pulmonary-metastases-after-liver-transplantation-for-unresectable-colorectal-liver-metastases
#9
H Grut, S Solberg, T Seierstad, M E Revheim, T S Egge, S G Larsen, P D Line, S Dueland
BACKGROUND: The previously reported SECA study demonstrated a dramatic 5-year survival improvement in patients with unresectable colorectal liver metastases (CLM) treated with liver transplantation (LT) compared with chemotherapy. The objective of this study was to assess whether immunosuppressive therapy accelerates the growth of pulmonary metastases in patients transplanted for unresectable CLM. METHODS: Chest CT scans from 11 patients in the SECA study resected for 18 pulmonary metastases were reviewed retrospectively...
November 23, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29168556/preliminary-results-of-a-cohort-study-of-induction-chemotherapy-based-treatment-for-locally-recurrent-rectal-cancer
#10
D M G I van Zoggel, S J Bosman, M Kusters, G A P Nieuwenhuijzen, J S Cnossen, G J Creemers, G van Lijnschoten, H J T Rutten
BACKGROUND: A significant number of patients treated for locally recurrent rectal cancer have local or systemic failure, especially after incomplete surgical resection. Neoadjuvant treatment regimens in patients who have already undergone preoperative (chemo)radiotherapy for the primary tumour are limited. The objective of the present study was to evaluate the influence of a neoadjuvant regimen incorporating induction chemotherapy (ICT) in patients with locally recurrent rectal cancer who had preoperative (chemo)radiotherapy for the primary cancer or an earlier local recurrence...
November 23, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29160918/impact-of-weight-loss-and-eating-difficulties-on-health-related-quality-of-life-up-to-10%C3%A2-years-after-oesophagectomy-for-cancer
#11
P Anandavadivelan, A Wikman, A Johar, P Lagergren
BACKGROUND: Severe weight loss is experienced by patients with eating difficulties after surgery for oesophageal cancer. The aim of this prospective cohort study was to asssess the influence of eating difficulties and severe weight loss on health-related quality of life (HRQoL) up to 10 years after oesophagectomy. METHODS: Data on bodyweight and HRQoL were collected at 6 months, 3, 5 and 10 years in patients who underwent surgery for oesophageal cancer in Sweden between 2001 and 2005...
November 21, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29155448/influence-of-national-centralization-of-oesophagogastric-cancer-on-management-and-clinical-outcome-from-emergency-upper-gastrointestinal-conditions
#12
S R Markar, H Mackenzie, T Wiggins, A Askari, A Karthikesalingam, O Faiz, S M Griffin, J D Birkmeyer, G B Hanna
BACKGROUND: In England in 2001 oesophagogastric cancer surgery was centralized. The aim of this study was to evaluate whether centralization of oesophagogastric cancer to high-volume centres has had an effect on mortality from different emergency upper gastrointestinal conditions. METHODS: The Hospital Episode Statistics database was used to identify patients admitted to hospitals in England (1997-2012). The influence of oesophagogastric high-volume cancer centre status (20 or more resections per year) on 30- and 90-day mortality from oesophageal perforation, paraoesophageal hernia and perforated peptic ulcer was analysed...
November 20, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29139566/patient-reported-rates-of-chronic-pain-and-recurrence-after-groin-hernia-repair
#13
K-J Lundström, H Holmberg, A Montgomery, P Nordin
BACKGROUND: The effectiveness of different procedures in routine surgical practice for hernia repair with respect to chronic postoperative pain and reoperation rates is not clear. METHODS: This was prospective cohort study based on a unique combination of patient-reported outcomes and national registry data. Virtually all patients with a groin hernia repair in Sweden between September 2012 and April 2015 were sent a questionnaire 1 year after surgery. Persistent pain, defined as at least 'pain present, cannot be ignored, and interferes with concentration on everyday activities' in the past week was the primary outcome...
November 15, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29131313/risk-score-to-predict-biliary-leakage-after-elective-liver-resection
#14
K Mohkam, O Farges, E Vibert, O Soubrane, R Adam, F-R Pruvot, J-M Regimbeau, M Adham, E Boleslawski, J-Y Mabrut
BACKGROUND: Biliary leakage remains a major cause of morbidity after liver resection. Previous prognostic studies of posthepatectomy biliary leakage (PHBL) lacked power, population homogeneity, and model validation. The present study aimed to develop a risk score for predicting severe PHBL. METHODS: In this multicentre observational study, patients who underwent liver resection without hepaticojejunostomy in one of nine tertiary centres between 2012 and 2015 were randomly assigned to a development or validation cohort in a 2 : 1 ratio...
November 13, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29131303/population-based-incidence-rate-of-inpatient-and-outpatient-surgical-procedures-in-a-high-income-country
#15
E Omling, A Jarnheimer, J Rose, J Björk, J G Meara, L Hagander
BACKGROUND: The WHO and the World Bank ask countries to report the national volume of surgery. This report describes these data for Sweden, a high-income country. METHODS: In an 8-year population-based observational cohort study, all inpatient and outpatient care in the public and private sectors was detected in the Swedish National Patient Register and screened for the occurrence of surgery. The entire Swedish population was eligible for inclusion. All patients attending healthcare for any disease were included...
November 13, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29116657/international-validation-of-the-european-organisation-for-research-and-treatment-of-cancer-qlq-brecon23-quality-of-life-questionnaire-for-women-undergoing-breast-reconstruction
#16
Z E Winters, M Afzal, C Rutherford, B Holzner, G Rumpold, R A da Costa Vieira, S Hartup, K Flitcroft, V Bjelic-Radisic, A Oberguggenberger, M Panouilleres, M Mani, G Catanuto, M Douek, J Kokan, P Sinai, M T King
BACKGROUND: The aim was to carry out phase 4 international field-testing of the European Organisation for Research and Treatment of Cancer (EORTC) breast reconstruction (BRECON) module. The primary objective was finalization of its scale structure. Secondary objectives were evaluation of its reliability, validity, responsiveness, acceptability and interpretability in patients with breast cancer undergoing mastectomy and reconstruction. METHODS: The EORTC module development guidelines were followed...
November 8, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29116656/all-cause-and-cardiovascular-mortality-risk-after-surgery-versus-radioiodine-treatment-for-hyperthyroidism
#17
P Giesecke, V Frykman, G Wallin, S Lönn, A Discacciati, O Törring, M Rosenqvist
BACKGROUND: Little is known about the long-term side-effects of different treatments for hyperthyroidism. The few studies previously published on the subject either included only women or focused mainly on cancer outcomes. This register study compared the impact of surgery versus radioiodine on all-cause and cause-specific mortality in a cohort of men and women. METHODS: Healthcare registers were used to find hyperthyroid patients over 35 years of age who were treated with radioiodine or surgery between 1976 and 2000...
November 8, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29116654/cardiovascular-and-all-cause-mortality-in-patients-with-intermittent-claudication-and-critical-limb-ischaemia
#18
S T W van Haelst, C Koopman, H M den Ruijter, F L Moll, F L Visseren, I Vaartjes, G J de Borst
BACKGROUND: The aim of this study was to evaluate absolute mortality risks and to determine whether changes in mortality risk occurred in patients with intermittent claudication (IC) or critical limb ischaemia (CLI) in the Netherlands between 1998 and 2010. METHODS: Data for patients treated between 1998 and 2010 were obtained from Dutch nationwide registers: the Hospital Discharge Register, Population Register and Cause of Death Register. The registers were used to obtain information regarding IC and CLI hospitalizations, co-morbidities, demographic factors, and date and cause of death...
November 8, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29116653/mir-128-regulation-of-glucose-metabolism-and-cell-proliferation-in-triple-negative-breast-cancer
#19
M Xiao, C Lou, H Xiao, Y Yang, X Cai, C Li, S Jia, Y Huang
BACKGROUND: Triple-negative breast cancer (TNBC) is prone to metastasis and has a poor prognosis, with lower survival rates than other breast cancer subtypes. MicroRNAs have recently emerged as powerful regulators of cancer processes and become a promising target in cancer therapy. METHODS: Expression of miR-128 was examined in invasive ductal breast cancer, and its relationship with clinicopathological features analysed. A series of in vitro and in vivo experiments were performed to investigate the function and mechanism of miR-128 in the development of invasive ductal breast cancer...
November 8, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29114846/savings-from-reducing-low-value-general-surgical-interventions
#20
REVIEW
H T Malik, J Marti, A Darzi, E Mossialos
BACKGROUND: Finding opportunities for improving efficiency is important, given the pressure on national health budgets. Identifying and reducing low-value interventions that deliver little benefit is key. A systematic literature evaluation was done to identify low-value interventions in general surgery, with further assessment of their cost. METHODS: A multiplatform method of identifying low value interventions was undertaken, including a broad literature search, a targeted database search, and opportunistic sampling...
November 8, 2017: British Journal of Surgery
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