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British Journal of Surgery

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https://www.readbyqxmd.com/read/29790154/omission-of-surgery-in-older-women-with-early-breast-cancer-has-an-adverse-impact-on-breast-cancer-specific-survival
#1
S E Ward, P D Richards, J L Morgan, G R Holmes, J W Broggio, K Collins, M W R Reed, L Wyld
BACKGROUND: Primary endocrine therapy is used as an alternative to surgery in up to 40 per cent of women with early breast cancer aged over 70 years in the UK. This study investigated the impact of surgery versus primary endocrine therapy on breast cancer-specific survival (BCSS) in older women. METHODS: Cancer registration data for 2002-2010 were obtained from two English regions. A retrospective analysis was performed for women with oestrogen receptor (ER)-positive disease, using statistical modelling to show the effect of treatment (surgery or primary endocrine therapy) and age and health status on BCSS...
May 22, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29770959/ten-years-of-the-surgical-safety-checklist
#2
T G Weiser, A B Haynes
No abstract text is available yet for this article.
May 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29744860/oncological-outcome-after-mri-based-selection-for-neoadjuvant-chemoradiotherapy-in-the-ocum-rectal-cancer-trial
#3
R Ruppert, T Junginger, H Ptok, J Strassburg, C A Maurer, P Brosi, J Sauer, J Baral, M Kreis, D Wollschlaeger, P Hermanek, S Merkel
BACKGROUND: It is not clear whether all patients with rectal cancer need chemoradiotherapy. A restrictive use of neoadjuvant chemoradiotherapy (nCRT) based on MRI findings for rectal cancer was investigated in this study. METHODS: This prospective multicentre observational study included patients with stage cT2-4 rectal cancer, with any cN and cM0 status. Carcinomas in the middle and lower third that were 1 mm or less from the mesorectal fascia, all cT4 tumours, and all cT3 tumours of the lower third were classified as high risk, and these patients received nCRT followed by total mesorectal excision (TME)...
May 9, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29741294/synaptotagmin-xiii-expression-and-peritoneal-metastasis-in-gastric-cancer
#4
M Kanda, D Shimizu, H Tanaka, C Tanaka, D Kobayashi, M Hayashi, H Takami, Y Niwa, S Yamada, T Fujii, H Sugimoto, Y Kodera
BACKGROUND: Peritoneal metastasis is a frequent cause of death in patients with gastric cancer. The aim of this study was to identify molecules responsible for mediating peritoneal metastasis of gastric cancer. METHODS: Transcriptome and bioinformatics analyses were conducted to identify molecules associated with peritoneal metastasis. The therapeutic effects of intraperitoneally administered small interfering (si) RNA were evaluated using mouse xenograft models...
May 9, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29738626/validation-of-at-least-1-mm-as-cut-off-for-resection-margins-for-pancreatic-adenocarcinoma-of-the-body-and-tail
#5
T Hank, U Hinz, I Tarantino, J Kaiser, W Niesen, F Bergmann, T Hackert, M W Büchler, O Strobel
BACKGROUND: The definition of resection margin (R) status in pancreatic cancer is under debate. Although a margin of at least 1 mm is an independent predictor of survival after resection for pancreatic head cancer, its relevance to pancreatic body and tail cancers remains unclear. This study aimed to validate R status based on a 1-mm tumour-free margin as a prognostic factor for resected adenocarcinoma involving the pancreatic body and tail. METHODS: Patients who underwent distal or total pancreatectomy for adenocarcinomas of the pancreatic body and tail between January 2006 and December 2014 were identified from a prospective database...
May 8, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29737513/development-and-validation-of-a-difficulty-score-to-predict-intraoperative-complications-during-laparoscopic-liver-resection
#6
M C Halls, G Berardi, F Cipriani, L Barkhatov, P Lainas, S Harris, M D'Hondt, F Rotellar, I Dagher, L Aldrighetti, R I Troisi, B Edwin, M Abu Hilal
BACKGROUND: Previous studies have demonstrated that patient, surgical, tumour and operative variables affect the complexity of laparoscopic liver resections. However, current difficulty scoring systems address only tumour factors. The aim of this study was to develop and validate a predictive model for the risk of intraoperative complications during laparoscopic liver resections. METHODS: The prospectively maintained databases of seven European tertiary referral liver centres were compiled...
May 8, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29708592/meta-analysis-comparing-upfront-surgery-with-neoadjuvant-treatment-in-patients-with-resectable-or-borderline-resectable-pancreatic-cancer
#7
REVIEW
E Versteijne, J A Vogel, M G Besselink, O R C Busch, J W Wilmink, J G Daams, C H J van Eijck, B Groot Koerkamp, C R N Rasch, G van Tienhoven
BACKGROUND: Studies comparing upfront surgery with neoadjuvant treatment in pancreatic cancer may report only patients who underwent resection and so survival will be skewed. The aim of this study was to report survival by intention to treat in a comparison of upfront surgery versus neoadjuvant treatment in resectable or borderline resectable pancreatic cancer. METHODS: MEDLINE, Embase and the Cochrane Library were searched for studies reporting median overall survival by intention to treat in patients with resectable or borderline resectable pancreatic cancer treated with or without neoadjuvant treatment...
April 30, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29691863/population-based-study-of-mortality-and-major-amputation-following-lower-limb-revascularization
#8
K Heikkila, I M Loftus, D C Mitchell, A S Johal, S Waton, D A Cromwell
BACKGROUND: The aim of this study was to estimate separate risks of major lower limb amputation and death following revascularization for peripheral artery disease (PAD) using competing risks analysis. METHODS: Routinely collected data from Hospital Episode Statistics (HES) were used to identify patients who underwent endovascular or open lower limb revascularization for PAD in England from 2005 to 2015. The primary outcomes were major lower limb amputation and death within 5 years of revascularization...
April 25, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29691844/genetic-and-morphological-evaluation-game-score-for-patients-with-colorectal-liver-metastases
#9
G A Margonis, K Sasaki, S Gholami, Y Kim, N Andreatos, N Rezaee, A Deshwar, S Buettner, P J Allen, T P Kingham, T M Pawlik, J He, J L Cameron, W R Jarnagin, C L Wolfgang, M I D'Angelica, M J Weiss
BACKGROUND: This study sought to develop a clinical risk score for resectable colorectal liver metastasis (CRLM) by combining clinicopathological and clinically available biological indicators, including KRAS. METHODS: A cohort of patients who underwent resection for CRLM at the Johns Hopkins Hospital (JHH) was analysed to identify independent predictors of overall survival (OS) that can be assessed before operation; these factors were combined into the Genetic And Morphological Evaluation (GAME) score...
April 25, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29691840/cost-effectiveness-of-population-based-vascular-disease-screening-and-intervention-in-men-from-the-viborg-vascular-viva-trial
#10
R Søgaard, J S Lindholt
BACKGROUND: Population-based screening and intervention for abdominal aortic aneurysm, peripheral artery disease and hypertension was recently reported to reduce the relative risk of mortality among Danish men by 7 per cent. The aim of this study was to investigate the cost-effectiveness of vascular screening versus usual care (ad hoc primary care-based risk assessment) from a national health service perspective. METHODS: A cost-effectiveness evaluation was conducted alongside an RCT involving all men from a region in Denmark (50 156) who were allocated to screening (25 078) or no screening (25 078) and followed for up to 5 years...
April 25, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29691839/gene-expression-profiles-for-a-prognostic-immunoscore-in-gastric-cancer
#11
D Zeng, R Zhou, Y Yu, Y Luo, J Zhang, H Sun, J Bin, Y Liao, J Rao, Y Zhang, W Liao
BACKGROUND: Increasing evidence has indicated an association between immune infiltration in gastric cancer and clinical outcome. However, reliable prognostic signatures, based on systematic assessments of the immune landscape inferred from bulk tumour transcriptomes, have not been established. The aim was to develop an immune signature, based on the cellular composition of the immune infiltrate inferred from bulk tumour transcriptomes, to improve the prognostic predictions of gastric cancer...
April 25, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29688585/reappraisal-of-classification-of-distal-cholangiocarcinoma-based-on-tumour-depth
#12
H Aoyama, T Ebata, M Hattori, M Takano, H Yamamoto, M Inoue, Y Asaba, M Ando, M Nagino
BACKGROUND: In the eighth edition of the AJCC cancer staging classification, the T system for distal cholangiocarcinoma (DCC) has been revised from a layer-based to a depth-based approach. The aim of this study was to propose an optimal T classification using a measured depth in resectable DCC. METHODS: Patients who underwent pancreatoduodenectomy for DCC at 32 hospitals between 2001 and 2010 were included. The distance between the level of the naive bile duct and the deepest cancer cells was measured as depth of invasion (DOI)...
April 24, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29683483/randomized-clinical-trial-of-elective-resection-versus-observation-in-diverticulitis-with-extraluminal-air-or-abscess-initially-managed-conservatively
#13
K You, R Bendl, C Taut, R Sullivan, M Gachabayov, R Bergamaschi
BACKGROUND: The aim of this RCT was to determine whether elective resection following successful non-operative management of a first episode of acute sigmoid diverticulitis complicated by extraluminal air with or without abscess is superior to observation in terms of recurrence rates. METHODS: This was a single-centre, sequential design RCT. Patients were randomized to elective surgery or observation following non-operative management and colonoscopy. Non-operative management included nil by mouth, intravenous fluids, intravenous antibiotics, CT with intravenous contrast on arrival at hospital, and repeat CT with intravenous and rectal contrast on day 3 in hospital...
April 23, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29683203/risk-of-recurrence-and-death-in-patients-with-breast-cancer-after-delayed-deep-inferior-epigastric-perforator-flap-reconstruction
#14
H Adam, A C Docherty Skogh, Å Edsander Nord, I Schultz, J Gahm, P Hall, J Frisell, M Halle, J de Boniface
BACKGROUND: Postmastectomy reconstruction using a deep inferior epigastric perforator (DIEP) flap is increasingly being performed in patients with breast cancer. The procedure induces extensive tissue trauma, and it has been hypothesized that the release of growth factors, angiogenic agonists and immunomodulating factors may reactivate dormant micrometastasis. The aim of the present study was to estimate the risk of breast cancer recurrence in patients undergoing DIEP flap reconstruction compared with that in patients treated with mastectomy alone...
April 23, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29683188/prediction-of-major-complications-after-hepatectomy-using-liver-stiffness-values-determined-by-magnetic-resonance-elastography
#15
N Sato, A Kenjo, T Kimura, R Okada, T Ishigame, Y Kofunato, T Shimura, K Abe, H Ohira, S Marubashi
BACKGROUND: Liver fibrosis is a risk factor for hepatectomy but cannot be determined accurately before hepatectomy because diagnostic procedures are too invasive. Magnetic resonance elastography (MRE) can determine liver stiffness (LS), a surrogate marker for assessing liver fibrosis, non-invasively. The aim of this study was to investigate whether the LS value determined by MRE is predictive of major complications after hepatectomy. METHODS: This prospective study enrolled consecutive patients who underwent hepatic resection between April 2013 and August 2016...
April 23, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29683186/morbidity-and-mortality-according-to-age-following-gastrectomy-for-gastric-cancer
#16
S D Nelen, K Bosscha, V E P P Lemmens, H H Hartgrink, R H A Verhoeven, J H W de Wilt
BACKGROUND: This study investigated age-related differences in surgically treated patients with gastric cancer, and aimed to identify factors associated with outcome. METHODS: Data from the Dutch Upper Gastrointestinal Cancer Audit were used. All patients with non-cardia gastric cancer registered between 2011 and 2015 who underwent surgery were selected. Patients were analysed by age group (less than 70 years versus 70 years or more). Multivariable logistic regression was used to assess the influence of clinicopathological factors on morbidity and mortality...
April 23, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29667178/cost-utility-analysis-of-bariatric-surgery
#17
O Borisenko, V Lukyanov, A R Ahmed
BACKGROUND: The objective of the study was to evaluate the cost-utility of bariatric surgery in England. METHODS: A state-transition Markov model was developed to compare the costs and outcomes of two treatment approaches for patients with morbid obesity: bariatric surgery, including gastric bypass, sleeve gastrectomy and adjustable gastric banding; and non-surgical usual care. Parameters of the effectiveness of surgery and complications were informed by data from the UK National Bariatric Surgery Registry, the Scandinavian Obesity Registry and the Swedish Obese Subjects study...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29665031/mortality-following-surgery-for-trauma-in-an-indian-trauma-cohort
#18
M Mansourati, V Kumar, M Khajanchi, M L Saha, S Dharap, R Seger, M Gerdin Wärnberg
BACKGROUND: India accounts for 20 per cent of worldwide trauma mortality. Little is known about the quality of trauma surgery in an Indian setting. The aim of this study was to estimate the overall perioperative mortality rate, and to assess the association between type of acute surgical intervention and perioperative mortality among adult patients treated for trauma in an urban Indian setting. METHODS: Data were obtained from injured adult patients enrolled in four urban Indian hospitals during 2013-2015...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29665028/meta-analysis-evaluating-music-interventions-for-anxiety-and-pain-in-surgery
#19
REVIEW
A Y R Kühlmann, A de Rooij, L F Kroese, M van Dijk, M G M Hunink, J Jeekel
BACKGROUND: This study aimed to evaluate anxiety and pain following perioperative music interventions compared with control conditions in adult patients. METHODS: Eleven electronic databases were searched for full-text publications of RCTs investigating the effect of music interventions on anxiety and pain during invasive surgery published between 1 January 1980 and 20 October 2016. Results and data were double-screened and extracted independently. Random-effects meta-analysis was used to calculate effect sizes as standardized mean differences (MDs)...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29664999/randomized-clinical-trial-of-the-effect-of-a-fibrin-sealant-patch-on-pancreatic-fistula-formation-after-pancreatoduodenectomy
#20
M Schindl, R Függer, P Götzinger, F Längle, M Zitt, S Stättner, P Kornprat, K Sahora, D Hlauschek, M Gnant
BACKGROUND: The potential for a fibrin sealant patch to reduce the risk of postoperative pancreatic fistula (POPF) remains uncertain. The aim of this study was to evaluate whether a fibrin sealant patch is able to reduce POPF in patients undergoing pancreatoduodenectomy with pancreatojejunostomy. METHODS: In this multicentre trial, patients undergoing pancreatoduodenectomy were randomized to receive either a fibrin patch (patch group) or no patch (control group), and stratified by gland texture, pancreatic duct size and neoadjuvant treatment...
April 17, 2018: British Journal of Surgery
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