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British Journal of Surgery

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https://www.readbyqxmd.com/read/28102886/translational-research-in-surgical-oncology
#1
K Søreide, M Sund
No abstract text is available yet for this article.
January 19, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28093728/meta-analysis-of-the-potential-economic-impact-following-introduction-of-absorbable-antimicrobial-sutures
#2
REVIEW
D J Leaper, C E Edmiston, C E Holy
BACKGROUND: Despite several randomized trials, systematic reviews and meta-analyses that have demonstrated the effectiveness of antimicrobial (triclosan-coated or -impregnated) sutures (TCS), the clinical and economic impact of using these sutures compared with conventional non-antimicrobial-coated absorbable sutures (NCS) remains poorly documented. METHODS: An independent systematic review and meta-analysis of all published evidence from January 2005 to September 2016 comparing TCS with NCS was conducted...
January 17, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28093723/meta-analysis-and-trial-sequential-analysis-of-triclosan-coated-sutures-for-the-prevention-of-surgical-site-infection
#3
REVIEW
S W de Jonge, J J Atema, J S Solomkin, M A Boermeester
BACKGROUND: Triclosan-coated sutures (TCS) were developed to reduce the risk of surgical-site infection (SSI). Level 1A evidence of effectiveness has been presented in various recent meta-analyses, yet well designed RCTs have not been able to reproduce these favourable results. The aim of this study was to evaluate all available evidence critically with comprehensive analysis to seek a more reliable answer regarding the effectiveness of TCS in the prevention of SSI. METHODS: PubMed, MEDLINE, Embase and Cochrane Library databases were searched from 1990 to November 2015 for RCTs that compared TCS with sutures that were exactly the same, but uncoated, in the prevention of SSI...
January 17, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28093719/metabolic-nodal-response-as-a-prognostic-marker-after-neoadjuvant-therapy-for-oesophageal-cancer
#4
J M Findlay, K M Bradley, L M Wang, J M Franklin, E J Teoh, F V Gleeson, N D Maynard, R S Gillies, M R Middleton
BACKGROUND: The ability to predict recurrence and survival after neoadjuvant chemotherapy (NAC) and surgery for oesophageal cancer remains elusive. This study evaluated the role of [(18) F]fluorodeoxyglucose (FDG) PET-CT in assessing tumour and nodal response as a prognostic marker. METHODS: This was a single-centre UK cohort study. From 2006 to 2014, patients with oesophageal cancer staged with PET-CT before NAC, and restaged by CT or PET-CT before resection, were included...
January 17, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28092401/randomized-clinical-trial-of-preoperative-oral-versus-intravenous-iron-in-anaemic-patients-with-colorectal-cancer
#5
B D Keeler, J A Simpson, O Ng, H Padmanabhan, M J Brookes, A G Acheson
BACKGROUND: Treatment of preoperative anaemia is recommended as part of patient blood management, aiming to minimize perioperative allogeneic red blood cell transfusion. No clear evidence exists outlining which treatment modality should be used in patients with colorectal cancer. The study aimed to compare the efficacy of preoperative intravenous and oral iron in reducing blood transfusion use in anaemic patients undergoing elective colorectal cancer surgery. METHODS: Anaemic patients with non-metastatic colorectal adenocarcinoma were recruited at least 2 weeks before surgery and randomized to receive oral (ferrous sulphate) or intravenous (ferric carboxymaltose) iron...
January 16, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28079259/three-point-transfusion-risk-score-in-hepatectomy
#6
M Lemke, C H L Law, J Li, E Dixon, M Tun Abraham, R Hernandez Alejandro, S Bennett, G Martel, P J Karanicolas
BACKGROUND: Perioperative red blood cell transfusions are required in up to 23 per cent of patients undergoing hepatectomy. Previous research has developed three transfusion risk scores to assess risk of perioperative red blood cell transfusion. Here, the performance of these transfusion risk scores was evaluated in a multicentre cohort of patients who underwent hepatectomy and compared with that of a simplified transfusion risk score. METHODS: A database of patients undergoing hepatectomy at four specialized centres between 2008 and 2012 was developed...
January 12, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28079258/combined-effect-of-therapeutic-strategies-for-bleeding-injury-on-early-survival-transfusion-needs-and-correction-of-coagulopathy
#7
K Balvers, S van Dieren, K Baksaas-Aasen, C Gaarder, K Brohi, S Eaglestone, S Stanworth, P I Johansson, S R Ostrowski, J Stensballe, M Maegele, J C Goslings, N P Juffermans
BACKGROUND: The combined effects of balanced transfusion ratios and use of procoagulant and antifibrinolytic therapies on trauma-induced exsanguination are not known. The aim of this study was to investigate the combined effect of transfusion ratios, tranexamic acid and products containing fibrinogen on the outcome of injured patients with bleeding. METHODS: A prospective multicentre observational study was performed in six level 1 trauma centres. Injured patients who received at least 4 units of red blood cells (RBCs) were analysed and divided into groups receiving a low (less than 1 : 1) or high (1 or more : 1) ratio of plasma or platelets to RBCs, and in receipt or not of tranexamic acid or fibrinogen products (fibrinogen concentrates or cryoprecipitate)...
January 12, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28079252/outcomes-of-surgical-shunts-and-transjugular-intrahepatic-portasystemic-stent-shunts-for-complicated-portal-hypertension
#8
I Hosokawa, R Adam, M-A Allard, G Pittau, E Vibert, D Cherqui, A Sa Cunha, H Bismuth, M Miyazaki, D Castaing
BACKGROUND: Transjugular intrahepatic portasystemic stent shunt (TIPSS), instead of surgical shunt, has become the standard treatment for patients with complicated portal hypertension. This study compared outcomes in patients who underwent TIPSS or surgical shunting for complicated portal hypertension. METHODS: This was a retrospective study of all consecutive patients who received portasystemic shunts from 1994 to 2014 at a single institution. Patients who underwent surgical shunting were compared with those who had a TIPSS procedure following one-to-one propensity score matching...
January 12, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28072456/systemic-inflammatory-markers-and-outcome-in-patients-with-locally-advanced-adenocarcinoma-of-the-oesophagus-and-gastro-oesophageal-junction
#9
V P Jagadesham, S M Lagarde, A Immanuel, S M Griffin
BACKGROUND: Raised levels of systemic inflammatory markers are associated with poor survival in patients with cancer. The aim of this study was to assess the prognostic value of markers of systemic inflammation in patients with adenocarcinoma of the oesophagus or gastro-oesophageal junction. METHODS: Data from a consecutive series of patients undergoing transthoracic oesophagectomy following neoadjuvant therapy at a single centre were analysed. Fibrinogen, albumin, C-reactive protein, leucocyte differential and platelet counts were measured before surgery...
January 10, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28072447/randomized-clinical-trial-comparing-standard-diet-with-perioperative-oral-immunonutrition-in-total-gastrectomy-for-gastric-cancer
#10
S Ida, N Hiki, H Cho, K Sakamaki, S Ito, K Fujitani, N Takiguchi, Y Kawashima, K Nishikawa, M Sasako, T Aoyama, M Honda, T Sato, S Nunobe, T Yoshikawa
BACKGROUND: Total gastrectomy for gastric cancer is associated with excessive weight loss and decreased calorie intake. Nutritional support using eicosapentaenoic acid modulates immune function and limits catabolism in patients with advanced cancer, but its impact in the perioperative period is unclear. METHODS: This was a randomized phase III clinical trial of addition of eicosapentaenoic acid-rich nutrition to a standard diet in patients having total gastrectomy for gastric cancer...
January 10, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28072446/randomized-clinical-trial-of-preoperative-dexamethasone-on-postoperative-nausea-and-vomiting-after-laparoscopy-for-suspected-appendicitis
#11
J Kleif, A Kirkegaard, J Vilandt, I Gögenur
BACKGROUND: Few studies have investigated the effects of preoperative dexamethasone in acute surgical patients. This study examined the effects of 8 mg dexamethasone administered intravenously 30 min before surgery for suspected acute appendicitis. METHODS: A multicentre, parallel-group, double-blind, placebo-controlled study was conducted at two university hospitals in Denmark. Adults undergoing laparoscopic surgery for suspected appendicitis were eligible for inclusion...
January 10, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28052310/ten-year-report-on-axillary-recurrence-after-negative-sentinel-node-biopsy-for-breast-cancer-from-the-swedish-multicentre-cohort-study
#12
J de Boniface, J Frisell, L Bergkvist, Y Andersson
BACKGROUND: The omission of axillary lymph node dissection (ALND) in patients with breast cancer with a negative finding on sentinel node biopsy (SNB) has reduced arm morbidity substantially. Early follow-up reports have shown the rate of axillary recurrence to be significantly lower than expected, with a median false-negative rate of 7 per cent for SNB. Long-term follow-up is needed as recurrences may develop late. METHODS: The Swedish Multicentre Cohort Study included 3518 women with breast cancer and a clinically negative axilla, in whom SNB was planned...
January 4, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28052308/prognostic-value-of-carbohydrate-antigen-19-9-in-patients-undergoing-resection-of-biliary-tract-cancer
#13
S Yamashita, G Passot, T A Aloia, Y S Chun, M Javle, J E Lee, J-N Vauthey, C Conrad
BACKGROUND: The clinical significance of abnormally high levels of carbohydrate antigen (CA) 19-9 after resection of biliary tract cancer (BTC) is not well established. The aim of this study was to determine the prognostic value of CA19-9 normalization in patients undergoing resection of BTC with curative intent. METHODS: Patients with BTC undergoing resection with curative intent (1996-2015) were divided into those with normal preoperative CA19-9 level (normal CA19-9 group), those with an abnormally high preoperative CA19-9 level (over 37 units/ml) and normal postoperative CA19-9 level (normalization group), and those with an abnormally high preoperative CA19-9 level and abnormally high postoperative CA19-9 level (non-normalization group)...
January 4, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28004852/splenic-preservation-in-laparoscopic-distal-pancreatectomy
#14
M-H Dai, N Shi, C Xing, Q Liao, T-P Zhang, G Chen, W-M Wu, J-C Guo, Z-W Liu, Y-P Zhao
BACKGROUND: Laparoscopic spleen-preserving distal pancreatectomy (LSPDP) is designed principally for the removal of benign and low-grade malignant lesions in the left pancreas. The aims of this study were to compare LSPDP with laparoscopic distal pancreatectomy with splenectomy (LDPS), compare two splenic preservation techniques (splenic vessel preservation and Warshaw technique) and investigate factors that influence splenic preservation. METHODS: Information from patients who underwent laparoscopic distal pancreatectomy between December 2004 and January 2016 at a single institution was reviewed...
December 22, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/28004850/meta-analysis-of-prophylactic-mesh-to-prevent-parastomal-hernia
#15
REVIEW
A J Cross, P L Buchwald, F A Frizelle, T W Eglinton
BACKGROUND: Rates of parastomal hernia following stoma formation remain high. Previous systematic reviews suggested that prophylactic mesh reduces the rate of parastomal hernia; however, a larger trial has recently called this into question. The aim was to determine whether mesh placed at the time of primary stoma creation prevents parastomal hernia. METHODS: The Cochrane Central Register of Controlled Trials, MEDLINE, Embase and CINAHL were searched using medical subject headings for parastomal hernia, mesh and prevention...
December 22, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/28001294/longitudinal-analysis-of-reporting-and-quality-of-systematic-reviews-in-high-impact-surgical-journals
#16
REVIEW
S J Chapman, T M Drake, W S Bolton, J Barnard, A Bhangu
BACKGROUND: The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) Statement aims to optimize the reporting of systematic reviews. The performance of the PRISMA Statement in improving the reporting and quality of surgical systematic reviews remains unclear. METHODS: Systematic reviews published in five high-impact surgical journals between 2007 and 2015 were identified from online archives. Manuscripts blinded to journal, publication year and authorship were assessed according to 27 reporting criteria described by the PRISMA Statement and scored using a validated quality appraisal tool (AMSTAR, Assessing the Methodological Quality of Systematic Reviews)...
December 21, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/28000931/network-meta-analysis-of-the-effect-of-preoperative-carbohydrate-loading-on-recovery-after-elective-surgery
#17
REVIEW
M A Amer, M D Smith, G P Herbison, L D Plank, J L McCall
BACKGROUND: Three meta-analyses have summarized the effects of preoperative carbohydrate administration on postoperative outcomes in adult patients undergoing elective surgery. However, these studies could not account for the different doses of carbohydrate administered and the different controls used. Multiple-treatments meta-analysis allows robust synthesis of all available evidence in these situations. METHODS: Article databases were searched systematically for RCTs comparing preoperative carbohydrate administration with water, a placebo drink, or fasting...
December 21, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27990637/gastrointestinal-symptoms-and-food-intolerance-2-years-after-laparoscopic-roux-en-y-gastric-bypass-for-morbid-obesity
#18
T C C Boerlage, A W J M van de Laar, S Westerlaken, V E A Gerdes, D P M Brandjes
BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) is an effective treatment for morbid obesity, but might aggravate gastrointestinal complaints and food intolerance. The long-term prevalence of these symptoms has not been well studied. METHODS: In a cross-sectional study, all patients who underwent primary LRYGB from May to October 2012 were approached 2 years after surgery to complete a general health questionnaire, the Gastrointestinal Symptom Rating Scale (GSRS), and a food intolerance questionnaire...
December 19, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27935014/systematic-review-and-qualitative-evidence-synthesis-of-patient-reported-outcome-measures-for-abdominal-aortic-aneurysm
#19
REVIEW
R Duncan, M Essat, G Jones, A Booth, H Buckley Woods, E Poku, E Kaltenthaler, A D Keetharuth, S Palfreyman, J Michaels
BACKGROUND: The aim was to identify and evaluate existing patient-reported outcome measures (PROMs) for use in patients with an abdominal aortic aneurysm (AAA) to inform the selection for use in surgical practice. METHODS: Two reviews were conducted: a systematic review to identify valid, reliable and acceptable PROMs for patients with an AAA, and a qualitative evidence synthesis to assess the relevance to patients of the identified PROM items. PROM studies were evaluated for their psychometric properties using established assessment criteria, and for their methodological quality using the COSMIN checklist...
December 9, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27918069/quality-of-reporting-in-surgical-randomized-clinical-trials
#20
J Yu, X Li, Y Li, X Sun
BACKGROUND: RCTs testing surgical interventions can change clinical practice. The adequate reporting of surgical trials is an important issue. METHODS: A cross-sectional survey was undertaken by searching PubMed for two-arm parallel randomized trials assessing surgical interventions published in 2003 or 2013. Quality of reporting was evaluated against the CONSORT checklist containing 29 items (standard CONSORT plus CONSORT Extension for Trials Assessing Non-Pharmacological Treatments)...
December 5, 2016: British Journal of Surgery
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