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British Journal of Ophthalmology

Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal, Ruchika Pattanaik, Ekta Rishi, Pukhraj Rishi, Shanmugasundaram Shanmugasundaram, Viswanathan Natarajan
PURPOSE: To analyse the functional and anatomical outcomes of different types of keratoprostheses in eyes with retained silicone oil following vitreoretinal surgery. METHODS: Retrospective chart review of patients operated with any type of permanent keratoprosthesis (Kpro) in silicone oil-filled eyes between March 2003 and June 2017 were analysed.. RESULTS: 40 silicone oil-filled eyes underwent keratoprostheses, of which 22 were type 1 and 18 were type 2 Kpros (Lucia variant-nine, modified osteo odonto kerato prosthesis (MOOKP)-four, Boston type 2-three and osteoKpro-two) with a mean follow-up of 61...
July 18, 2018: British Journal of Ophthalmology
Yongheng Huang, Lei Zhou, Jingzi ZhangBao, Tongjia Cai, Bei Wang, Xiaoyang Li, Liang Wang, Chuanzhen Lu, Chongbo Zhao, Jiahong Lu, Chao Quan, Min Wang
BACKGROUND/AIMS: Current understanding of the alterations in the retinal vascular network in neuromyelitis optica spectrum disorders (NMOSDs) is limited. We aim to assess the peripapillary and parafoveal vessel density in aquaporin-4 antibody-positive NMOSD patients by optical coherence tomography (OCT) angiography. METHODS: A total of 55 aquaporin-4 antibody-positive NMOSD patients with or without a history of optic neuritis (ON) and 33 healthy controls underwent spectral domain OCT and OCT angiography...
July 18, 2018: British Journal of Ophthalmology
Shi Zhuan Tan, Kenneth Yau, Laura R Steeples, Jane Ashworth, Cecilia Fenerty, Nicholas Jones
BACKGROUND/AIMS: To investigate the incidence, management and outcome of uveitis and raised intraocular pressure (IOP) in children treated at the Manchester Uveitis Clinic (MUC). METHODS: This was a retrospective, observational study of patients who presented with uveitis under the age of 16 to the MUC from July 2002 to June 2016. RESULTS: A total of 320 children were included in the study. Out of these, 55 (17.2%) patients (75 eyes) were found to have raised IOP requiring treatment...
July 18, 2018: British Journal of Ophthalmology
Oded Sagiv, Priyadharsini Nagarajan, Renata Ferrarotto, Thomas J Kandl, Sudip D Thakar, Bonnie S Glisson, Mehmet Altan, Bita Esmaeli
BACKGROUND/AIMS: Locally advanced (T4 per American Joint Committee on Cancer (AJCC) 8th edition) periocular basal cell carcinoma (BCC) can lead to loss of the eye. We report the neoadjuvant use of vismodegib followed by surgery in patients with such lesions with eye preservation as primary goal. METHODS: This retrospective interventional study includes all patients with a T4 periocular BCC (per 8th edition AJCC for eyelid carcinoma) treated by the senior author between 2013 and 2017 with neoadjuvant vismodegib prior to definitive surgery...
July 18, 2018: British Journal of Ophthalmology
Quangang Xu, Wenjuan Du, Huanfen Zhou, Xin Zhang, Hongjuan Liu, Honglu Song, Xueqiong Wang, Shihui Wei
OBJECTIVE: Paraneoplastic optic neuropathy (PON) is relatively uncommon, and the visual outcomes and prognosis of this disease have not been well documented. The aim of this study was to investigate the clinical features and prognosis of antibody-mediated PON. METHODS: Clinical data were retrospectively collected from hospitalised patients diagnosed with PON at the Neuro-Ophthalmology Department at the Chinese People's Liberation Army General Hospital from January 2015 to June 2017...
July 18, 2018: British Journal of Ophthalmology
Li Fong Seet, Yang Fei Tan, Li Zhen Toh, Stephanie Wl Chu, Ying Shi Lee, Subbu S Venkatraman, Tina T Wong
BACKGROUND: To develop targeted antifibrotic therapy for glaucoma filtration surgery; this study determines the effectiveness of small interfering RNA (siRNA) to reduce in vivo secreted protein acidic and rich in cysteine (SPARC) expression using the mouse model of conjunctival scarring. METHODS: Experimental surgery was performed as described for the mouse model of conjunctival scarring. Scrambled (siScram) or Sparc (siSparc) siRNAs, loaded on layer-by-layer (LbL) nanoparticles, were injected into the conjunctiva immediately after surgery...
July 18, 2018: British Journal of Ophthalmology
Shu Min Tang, Tiffany Lau, Shi Song Rong, Seyhan Yazar, Li Jia Chen, David A Mackey, Robyn M Lucas, Chi Pui Pang, Jason C Yam
OBJECTIVE: To conduct a systematic review and meta-analysis of the association of blood vitamin D (25-hydroxyvitamin D, 25(OH)D) concentration and vitamin D pathway genes with myopia. METHODS: We searched the MEDLINE and EMBASE databases for studies published up to 29 January 2018. Cross-sectional or cohort studies which evaluated the blood 25(OH)D concentration, blood 25(OH)D3 concentration or vitamin D pathway genes, in relation to risk of myopia or refractive errors were included...
July 17, 2018: British Journal of Ophthalmology
M Giray Ersoz, Serra Arf, Mumin Hocaoglu, Isil Sayman Muslubas, Murat Karacorlu
AIMS: To determine the demographic and morphological characteristics of patients with central serous chorioretinopathy (CSC) and describe risk factors for CSC. METHODS: We retrospectively reviewed medical records of 811 patients with CSC and 816 healthy controls referred from 2002 to 2018. RESULTS: The female/male ratio of patients with CSC was 1/2.7. Mean age of onset was 45.2 years. The peak prevalence for men occurred at 45-49 years. Women had two prevalence peaks, the higher at 55-59 years and the other at 45-49 years...
July 12, 2018: British Journal of Ophthalmology
Matthew Yu Heng Wong, Nicholas Y Q Tan, Charumathi Sabanayagam
We analysed the 100 top cited articles in ophthalmology to identify and characterise the most influential articles of the past four decades. Two independent investigators searched the Scopus database to determine the 100 most frequently cited articles in ophthalmology (T100-Eye) and general non-ophthalmology journals (T100-Gen) published from 1975 to December 2017. The T100-Eye list consisted of 83 original articles and 17 reviews, and the number of citations ranged from 582 to 2833. Seventy-eight of these articles were published in three journals alone (impact factor (IF): 5...
July 12, 2018: British Journal of Ophthalmology
Yu Meng Wang, Li Ma, Shi Yao Lu, Tommy Chung Yan Chan, Jason C S Yam, Shu Min Tang, Ka Wai Kam, Pancy O S Tam, Clement C Tham, Alvin L Young, Vishal Jhanji, Chi Pui Pang, Li Jia Chen
OBJECTIVE: To investigate the associations between 16 single-nucleotide polymorphisms (SNPs) in 14 genetic loci and keratoconus in an independent Chinese cohort. METHODS: This cross-sectional, case-control association study included a Chinese cohort of 133 patients with keratoconus and 371 control subjects. In a recent meta-analysis study, we identified association of 16 SNPs in 14 gene loci with keratoconus. In this study, we genotyped these 16 SNPs in all the patients and controls and analysed their association with keratoconus, its clinical severities and progression profiles...
July 12, 2018: British Journal of Ophthalmology
Sumit Randhir Singh, Alexandre Matet, Elon H C van Dijk, Alejandra Daruich, Sascha Fauser, Suzanne Yzer, Enrico Peiretti, Sobha Sivaprasad, Andrew J Lotery, Camiel J F Boon, Francine Behar-Cohen, K Bailey Freund, Jay Chhablani
AIM: To report the discordance in central serous chorioretinopathy (CSCR) classification among practising retina specialists. METHODS: The study conducted was a multicentre survey. Multimodal retinal images along with relevant clinical details of 100 cases diagnosed as CSCR (from six centres) were circulated among six retina specialists across the globe. The image sets included colour fundus photographs, fundus autofluorescence images, optical coherence tomography b-scans, fluorescein and indocyanine green angiography of the study and fellow eyes...
July 12, 2018: British Journal of Ophthalmology
Xuehan Qian, Ying Li, Gang Ding, Jing Li, Hongyu Lv, Ning Hua, Nan Wei, Li He, Lirong Wei, Xue Li, Jiaxing Wang
PURPOSE: To evaluate the effectiveness of Spot photoscreener and SW800 vision screener in detecting amblyopia risk factors in Chinese children between 4 and 6 years of age. METHODS: One hundred and thirteen children (226 eyes) underwent complete ophthalmologic examination, cycloplegic retinoscopy refraction, prism cover tests and photoscreen using both Spot (v2.1.4) and SW800 (v1.0.1.0) photoscreeners. The agreement of results obtained from photoscreener and retinoscopy was evaluated by paired t-test as well as Pearson correlation test...
July 9, 2018: British Journal of Ophthalmology
Sameh E Soliman, Cynthia VandenHoven, Leslie D Mackeen, Brenda L Gallie
BACKGROUND/AIMS: To assess tumour control, vision and anatomical visual potential in eyes with perifoveal retinoblastoma treated by sequential photocoagulation from the antifoveal tumour edge inwards, avoiding treatment near the fovea. Patients were monitored for tumour control, foveal and perifoveal anatomy at each treatment session by optical coherence tomography (OCT) and treated for amblyopia when the other eye had better vision. METHODS: Eyes with perifoveal retinoblastoma treated between 1 January 2011 and 31 May 2017 with laser therapy after chemotherapy for juxtafoveal (fovea clear of tumour but <3000 µm from tumour edge) or foveolar retinoblastoma (tumour underlying fovea) were retrospectively reviewed for tumour control without recurrence, anatomical success (foveal pit preservation and/or restoration with ≥500 µm perifoveal retina free of tumour and scar) and functional success (acceptable (>0...
July 5, 2018: British Journal of Ophthalmology
Anthea Burnett, Ling Lee, Fabrizio D'Esposito, Geoffrey Wabulembo, Anaseini Cama, Georgia Guldan, Marleen Nelisse, Samuel Peter Koim, Drew Keys, Alison J Poffley, Hans Limburg, Jambi Garap
BACKGROUND/AIMS: To conduct an assessment of avoidable blindness, diabetes mellitus and diabetic retinopathy (DR) in adults aged 50 years and older in the National Capital District (NCD) region of Papua New Guinea (PNG). METHODS: A cross-sectional population-based survey was performed for which 25 clusters of 50 people aged ≥50 years were randomly selected from the NCD region. The standardised rapid assessment of avoidable blindness (RAAB) with diabetic retinopathy (+DR) methodology was used...
July 4, 2018: British Journal of Ophthalmology
Martha McKenna, Tingting Chen, Helen McAneney, Miguel Angel Vázquez Membrillo, Ling Jin, Wei Xiao, Tunde Peto, Mingguang He, Ruth Hogg, Nathan Congdon
BACKGROUND/AIMS: To determine the diagnostic accuracy of trained rural ophthalmologists and non-medical image graders in the assessment of diabetic retinopathy (DR) in rural China. METHODS: Consecutive patients with diabetes mellitus were examined from January 2014 to December 2015 at 10 county-level facilities in rural Southern China. Trained rural ophthalmologists performed a complete eye examination, recording diagnoses using the UK National Diabetic Eye Screening Programme (NDESP) classification system...
July 4, 2018: British Journal of Ophthalmology
David W Steven, Pouya Alaghband, Kin Sheng Lim
Preservatives continue to be in widespread use in ophthalmic medications due to the convenience they provide, regulatory requirements and the higher cost of alternatives. Benzalkonium chloride (BAK) remains the most commonly used preservative but there is a trend towards the use of preservative-free (PF) drops for glaucoma, although at a higher price. An extensive body of literature explores BAK toxicity on ocular structures in animal and laboratory studies (in vitro and in vivo). Non-randomised controlled studies have provided some supporting evidence of its toxicity in patients, especially in those with pre-existing ocular surface disease (OSD) or on multiple medications...
July 4, 2018: British Journal of Ophthalmology
Andreas Schatz, Vanessa Guggenberger, M Dominik Fischer, Kai Schommer, Karl Ulrich Bartz-Schmidt, Florian Gekeler, Gabriel Willmann
BACKGROUND/AIMS: The study aims to investigate changes in the optic nerve sheath diameter (ONSD) at high altitude and to assess correlation to optic disc oedema (ODE) and acute mountain sickness (AMS). This investigation is part of the Tübingen High Altitude Ophthalmology study. METHODS: Fourteen volunteers ascended to 4559 m for 4 days before returning to low altitude. Ultrasonography of ONSD, quantification of optic disc parameters using a scanning laser ophthalmoscope and fluorescein angiography were performed at 341 m and at high altitude...
July 4, 2018: British Journal of Ophthalmology
Min-Woo Lee, Kyeung-Min Kim, Hyung-Bin Lim, Young-Joon Jo, Jung-Yeul Kim
AIM: To analyse the repeatability of vessel density (VD) measurements using optical coherence tomography angiography (OCTA) in patients with retinal diseases. METHODS: Two consecutive VD measurements using OCTA were analysed prospectively in patients with retinal diseases (diabetic macular oedema (DME), retinal vein occlusion (RVO) with macular oedema, epiretinal membrane (ERM), wet age-related macular degeneration (AMD)). The intraclass correlation coefficient (ICC), coefficient of variation (CV) and test-retest SD of VD measurements were assessed, and linear regression analyses were conducted to identify factors related to repeatability...
July 4, 2018: British Journal of Ophthalmology
David M Wright, Dermot O'Reilly, Augusto Azuara-Blanco, Ruth E Hogg
AIM: To examine associations between uptake of free primary eye care, service availability (density of optometric practices) and service accessibility (household car access and drive time to nearest provider) after accounting for socioeconomic status and other individual, household and area factors. METHODS: We constructed a cohort of 294 870 community-dwelling adults aged 60 years, drawing contextual information from the 2011 Northern Ireland Census. Minimum drive times to the nearest optometry practice (1-19 min) and number of practices were derived for 890 geographical areas...
July 3, 2018: British Journal of Ophthalmology
Marcel Y Avila, Angela M Igua, Amparo M Mora
BACKGROUND: To evaluate the effectiveness of platelet-rich plasma (PRP) injections in the treatment of severe dry eye. METHODS: This prospective, intervention study included patients with severe dry eye who had been diagnosed with Sjogren syndrome. Patients were divided into two groups. The intervention group received PRP (n=15) injections on days 0, 30, 60 and 90, as well as hyaluronic acid five times per day. The comparison group received hyaluronic acid (n=15) five times per day...
July 3, 2018: British Journal of Ophthalmology
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