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British Journal of Ophthalmology

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https://www.readbyqxmd.com/read/29777048/corneal-shape-changes-of-the-total-and-posterior-cornea-after-temporal-versus-nasal-clear-corneal-incision-cataract-surgery
#1
Ken Hayashi, Tatsuhiko Sato, Motoaki Yoshida, Koichi Yoshimura
AIM: To compare changes in the shape and astigmatism of the total and posterior cornea between eyes with a nasal clear corneal incision (CCI) and eyes with a temporal CCI in cataract surgery. METHODS: The left eyes of 100 patients undergoing phacoemulsification were randomly assigned to undergo a 2.4 mm nasal (nasal CCI group) or temporal CCI (temporal CCI group). Corneal astigmatic changes were compared between groups using power vector analysis, and corneal shape changes were compared using videokeratography maps at 2 days, and at 2, 4 and 8 weeks postoperatively...
May 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29777047/in-vivo-confocal-microscopy-indicates-an-inverse-relationship-between-the-sub-basal-corneal-plexus-and-the-conjunctivalisation-in-patients-with-limbal-stem-cell-deficiency
#2
Manuel Caro-Magdaleno, Asunción Alfaro-Juárez, Jesús Montero-Iruzubieta, Ana Fernández-Palacín, Ana Muñoz-Morales, Manuel Alberto Castilla-Martino, Consuelo Spínola-Muñoz, Enrique Rodríguez-de-la-Rúa
BACKGROUND/AIMS: Limbal stem cell deficiency (LSCD) is characterised by a marked decrease in limbal stem cells. It is classified primarily using subjective slit-lamp observations. In vivo confocal microscopy (IVCM) can non-invasively provide objective information on the condition of the limbal niche, the corneal epithelial basal cell density and the corneal sub-basal nerve plexus density (SND). We here used IVCM to evaluate changes in SND to improve LSCD classification. METHODS: We evaluated and classified 38 patients (76 eyes, 44 with LSC and 32 control eyes) using the Rama, López-García and Deng (clinical and confocal) classifications and evaluated the concordance of the confocal and clinical classifications...
May 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29777046/lack-of-tumour-pigmentation-in-conjunctival-melanoma-is-associated-with-light-iris-colour-and-worse-prognosis
#3
Niels J Brouwer, Marina Marinkovic, Gregorius P M Luyten, Carol L Shields, Martine J Jager
AIM: To investigate whether differences in iris colour, skin colour and tumour pigmentation are related to clinical outcome in conjunctival melanoma. METHODS: Data of 70 patients with conjunctival melanoma from the Leiden University Medical Center (Leiden, The Netherlands) and 374 patients from the Wills Eye Hospital (Philadephia, USA) were reviewed. The relation between iris colour, skin colour and tumour pigmentation versus clinical parameters and outcome was investigated using univariate and multivariate regression analyses...
May 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29777045/ten-year-incidence-of-primary-angle-closure-in-elderly-chinese-the-liwan-eye-study
#4
Lanhua Wang, Wenyong Huang, Shengsong Huang, Jian Zhang, Xinxing Guo, David S Friedman, Paul J Foster, Mingguang He
PURPOSE: To determine the 10-year incidence of all forms of primary angle closure (PAC) in phakic eyes and its risk factors in an urban Chinese population aged 50 years and older. METHODS: Survivors of 1405 baseline participants were invited to attend the 10-year follow-up visit in the Liwan Eye Study. Participants with established baseline angle closure, including primary angle closure suspects (PACS), PAC and primary angle closure glaucoma (PACG), or those who underwent bilateral cataract surgery during the 10-year period, as well as those who did not tolerate gonioscopic examinations, were excluded from this analysis...
May 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29777044/the-impact-of-sign-glaucoma-guidelines-on-false-positive-referrals-from-community-optometrists-in-central-scotland
#5
Samantha Sii, Ahmad Nasser, Cheng Yi Loo, Catherine Croghan, Alan Rotchford, Pankaj Kumar Agarwal
BACKGROUND: Since the introduction of National Institute for Health and Care Excellence glaucoma guidelines 2009, the number of referrals from community optometrists to hospital eye services has increased across the UK, resulting in increase in first visit discharge rates (FVDRs). AIM: To assess the impact of Scottish Intercollegiate Guidelines Network (SIGN) 144 on quality of referrals from community optometrists. METHODOLOGY: A retrospective study of patient records who attended as new adult glaucoma referrals to clinics in Princess Alexandra Eye Pavilion, Edinburgh, and in Greater Glasgow and Clyde, was carried out across October-November 2014 (group 1) and September-October 2016 (group 2), before and after the introduction of SIGN 144...
May 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29777043/new-advances-in-amblyopia-therapy-i-binocular-therapies-and-pharmacologic-augmentation
#6
Courtney L Kraus, Susan M Culican
Amblyopia therapy options have traditionally been limited to penalisation of the non-amblyopic eye with either patching or pharmaceutical penalisation. Solid evidence, mostly from the Pediatric Eye Disease Investigator Group, has validated both number of hours a day of patching and days per week of atropine use. The use of glasses alone has also been established as a good first-line therapy for both anisometropic and strabismic amblyopia. Unfortunately, visual acuity equalisation or even improvement is not always attainable with these methods...
May 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29735479/comparison-of-long-term-clinical-evolution-in-highly-myopic-eyes-with-vertical-oval-shaped-dome-with-or-without-untreated-serous-retinal-detachment
#7
Antonio García-Ben, Ignacio Garcia-Basterra, Ana González-Gómez, Isabel Baquero-Aranda, María José Morillo-Sanchez, Antonio Soler-García, Jose Manuel García-Campos
BACKGROUND: To compare the long-term clinical evolution of highly myopic eyes with vertical oval-shaped dome associated with or without untreated serous retinal detachment. METHODS: Twenty-eight patients with high myopia (40 eyes) with smooth macular elevations related to a vertical oval-shaped dome were recruited. Serous retinal detachment was investigated; 11 eyes had persistent submacular fluid (study group) and 29 eyes lacked submacular fluid (control group)...
May 7, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29712637/efficacy-of-non-fovea-sparing-ilm-peeling-for-symptomatic-myopic-foveoschisis-with-and-without-macular-hole
#8
Amer Hamad Al-Badawi, Mohamad Amr Salah Eddin Abdelhakim, Tamer Ahmed Macky, Hassan Aly Mortada
AIM: To study anatomical and visual outcomes of pars plana vitrectomy (PPV) with non-fovea-sparing (entire) internal limiting membrane (ILM) peeling in eyes with myopic foveoschisis (MF). METHODS: Prospective interventional case series of eyes undergoing PPV with entire ILM peeling for symptomatic MF. MAIN OUTCOME MEASURES: Preoperative spectral domain optical coherence tomography (SD - OCT) epiretinal membrane, anomalous posterior vitreous detachment, vitreoschisis and postoperative changes in SD-OCT central foveal thickness (CFT), ellipsoid zone defect, foveal detachment (FD), macular hole (MH) diameter (if present) and best-corrected visual acuity (BCVA) in logarithm of the minimum angle of resolution (logMAR)...
April 30, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29706604/clinical-characteristics-and-treatment-outcomes-of-natural-killer-t-cell-lymphoma-involving-the-ocular-adnexa
#9
Ga-In Lee, Yoon-Duck Kim, Stephanie Ming Young, Seonae Shin, Kyung In Woo
AIMS: To evaluate the clinical characteristics and treatment outcomes of natural killer/T-cell lymphoma (NKTL) involving the ocular adnexa. METHODS: Retrospective, comparative, observational case series. A total of 350 patients with NKTL, including 27 patients with NKTL involving the ocular adnexa from 1999 to 2016. The patients were grouped into two groups: group 1 comprised patients presenting with ophthalmic symptoms, and group 2 comprised patients presenting with symptoms from other organs but subsequently developed ophthalmic involvement...
April 29, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29706603/impact-of-drusen-and-drusenoid-retinal-pigment-epithelium-elevation-size-and-structure-on-the-integrity-of-the-retinal-pigment-epithelium-layer
#10
Schlanitz Ferdinand, Bernhard Baumann, Stefan Sacu, Lukas Baumann, Michael Pircher, Christoph K Hitzenberger, Ursula Margarethe Schmidt-Erfurth
PURPOSE: To evaluate the impact of drusen size and structure on retinal pigment epithelium (RPE) and photoreceptor layers in eyes with early to intermediate age-related macular degeneration (AMD) using polarisation-sensitive optical coherence tomography (OCT). DESIGN: Retrospective investigation of an observational cross-sectional study. PARTICIPANTS: Patients with early to intermediate AMD. METHODS: Twenty-five eyes of 25 patients with drusen were imaged with polarisation-sensitive OCT using macular volume scans...
April 29, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29706602/association-between-hla-b-44-03-hla-c-07-01-haplotype-and-cold-medicine-related-stevens-johnson-syndrome-with-severe-ocular-complications-in-thailand
#11
Passara Jongkhajornpong, Kaevalin Lekhanont, Phattrawan Pisuchpen, Patchima Chantaren, Vilavun Puangsricharern, Pinnita Prabhasawat, Kanya Suphapeetiporn, Shigeru Kinoshita, Mayumi Ueta
BACKGROUND: Polymorphisms in human leucocyte antigen (HLA) class I genes have been found to be associated with cold medicine (CM)-related Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with severe ocular complications (SOC). Because ethnic differences in genetic predisposition to SJS/TEN among different populations have been proposed, we focused on Thai patients and investigated the association between HLA class I genotypes and CM-SJS/TEN with SOC. METHODS: This multicentre case-control study was conducted between September 2014 and August 2017...
April 29, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29706601/quantifying-vascular-density-and-morphology-using-different-swept-source-optical-coherence-tomography-angiographic-scan-patterns-in-diabetic-retinopathy
#12
Takao Hirano, Jyunya Kitahara, Yuichi Toriyama, Hirotsugu Kasamatsu, Toshinori Murata, Srinivas Sadda
AIMS: To evaluate quantitative metrics of the retinal microvasculature in eyes with diabetic retinopathy (DR) using various en face swept-source optical coherence tomography angiography (SS-OCTA) image sizes. METHODS: Non-segmented and segmented images were acquired using an SS-OCTA device (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA). The scanning protocols included the 3×3 mm, 6×6 mm and 12×12 mm fields of view. Quantitative analysis of the perfusion density (PD), vessel length density (VLD) and fractal dimension (FD) was performed...
April 29, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29706600/retrospective-cohort-study-exploring-whether-an-association-exists-between-spatial-distribution-of-cystoid-spaces-in-cystoid-macular-oedema-secondary-to-retinitis-pigmentosa-and-response-to-treatment-with-carbonic-anhydrase-inhibitors
#13
Stacey A Strong, Nashila Hirji, Ana Quartilho, Angelos Kalitzeos, Michel Michaelides
BACKGROUND: Carbonic anhydrase inhibitors (CAIs) are frequently used as an initial step to treat retinitis pigmentosa-associated cystoid macular oedema (RP-CMO). Interestingly, it has been postulated that CAIs might reduce outer nuclear layer (ONL) fluid more effectively than inner nuclear layer (INL) fluid due to better access to retinal pigment epithelium basolateral membrane than neurosensory retina. This retrospective cohort study explores if an association between spatial distribution of cystoid spaces in RP-CMO and CAI response exists...
April 29, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29699987/decreased-expression-of-a20-is-associated-with-ocular-behcet-s-disease-bd-but-not-with-vogt-koyanagi-harada-vkh-disease
#14
Yue He, Chaokui Wang, Guannan Su, Bolin Deng, Zi Ye, Yang Huang, Gangxiang Yuan, Kijlstra Aize, Hong Li, Peizeng Yang
PURPOSE: A20 is a ubiquitously expressed and inducible cytosolic protein, which plays an important role in the negative regulation of inflammation and immunity. In this study, we investigated the role of A20 in Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) disease. METHODS: The levels of A20 in peripheral blood mononuclear cells (PBMCs) and dendritic cells (DCs) were detected in BD patients with active and inactive uveitis, VKH patients with active and inactive uveitis, and normal subjects, respectively, by real-time PCR...
April 26, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29699986/resting-nailfold-capillary-blood-flow-in-primary-open-angle-glaucoma
#15
Clara C Cousins, Jonathan C Chou, Scott H Greenstein, Stacey C Brauner, Lucy Q Shen, Angela V Turalba, Patricia Houlihan, Robert Ritch, Janey L Wiggs, Paul A Knepper, Louis R Pasquale
BACKGROUND/AIMS: An altered haemodynamic profile for various ocular posterior segment capillary beds has been documented in primary open-angle glaucoma (POAG). POAG may also involve abnormal non-ocular blood flow, and the nailfold capillaries, which are not affected by elevated intraocular pressure (IOP), are readily assessable. METHODS: We measured resting nailfold capillary blood flow in 67 POAG and 63 control subjects using video capillaroscopy. Masked readers tracked blood column voids between consecutive, registered image sequence frames, measured vessel diameter and calculated blood flow...
April 26, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29699985/global-prevalence-of-visual-impairment-associated-with-myopic-macular-degeneration-and-temporal-trends-from-2000-through-2050-systematic-review-meta-analysis-and-modelling
#16
Timothy R Fricke, Monica Jong, Kovin S Naidoo, Padmaja Sankaridurg, Thomas J Naduvilath, Suit May Ho, Tien Yin Wong, Serge Resnikoff
PURPOSE: We used systematic review and meta-analysis to identify and assimilate evidence quantifying blindness and visual impairment (VI) associated with myopic macular degeneration (MMD), then derived models to predict global patterns. The models were used to estimate the global prevalence of blindness and VI associated with MMD from 2000 to 2050. METHODS: The systematic review identified 17 papers with prevalence data for MMD VI fitting our inclusion criteria...
April 26, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29699984/prevalence-of-glaucoma-in-the-australian-national-eye-health-survey
#17
Stuart Keel, Jing Xie, Joshua Foreman, Pei Ying Lee, Mostafa Alwan, Eamonn T Fahy, Peter van Wijngaarden, Jennifer C Fan Gaskin, Ghee Soon Ang, Jonathan G Crowston, Hugh R Taylor, Mohamed Dirani
AIM: To estimate the prevalence of glaucoma in Australia. METHODS: This was a population-based study of 3098 non-Indigenous Australians (50-98 years) and 1738 Indigenous Australians (40-92 years) stratified by remoteness. Each participant underwent a standard examination that included visual field assessment, tonometry and non-mydriatic fundus photography. Two fellowship-trained glaucoma specialists independently assessed relevant case notes (past ocular history, best-corrected visual acuity, frequency doubling technology visual fields, Van Herick grade, intraocular pressure and optic disc-centred photographs) and assigned a diagnosis ranked on a scale of certainty: none, possible, probable or definite glaucoma...
April 26, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29699983/correspondence-between-retinotopic-cortical-mapping-and-conventional-functional-and-morphological-assessment-of-retinal-disease
#18
Markus Ritter, Allan Hummer, Anna A Ledolter, Graham E Holder, Christian Windischberger, Ursula M Schmidt-Erfurth
PURPOSE: The present study describes retinotopic mapping of the primary visual cortex using functional MRI (fMRI) in patients with retinal disease. It addresses the relationship between fMRI data and data obtained by conventional assessment including microperimetry (MP) and structural imaging. METHODS: Initial testing involved eight patients with central retinal disease (Stargardt disease, STGD) and eight with peripheral retinal disease (retinitis pigmentosa, RP), who were examined using fMRI and MP (Nidek MP-1)...
April 26, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29699982/atypical-epiretinal-tissue-in-full-thickness-macular-holes-pathogenic-and-prognostic-significance
#19
Kunho Bae, Soo Min Lee, Se Woong Kang, Eung Suk Kim, Seung-Young Yu, Kyung Tae Kim
BACKGROUND: To elucidate the clinical characteristics of a full-thickness macular hole (FTMH) with atypical epiretinal tissue (AET), and expand the spectrum of pathogenesis of MH. METHODS: This study involved 225 consecutive eyes of 211 patients who underwent surgery for an idiopathic FTMH. Eyes were divided into two groups according to the presence of AET. Tomographic features at baseline, closure rate of the MH and visual outcomes were compared between the two groups...
April 26, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29699981/microaneurysm-turnover-is-a-predictor-of-diabetic-retinopathy-progression
#20
Rajeev K R Pappuru, Luísa Ribeiro, Conceição Lobo, Dalila Alves, José Cunha-Vaz
AIM: To analyse retinopathy phenotypes and microaneurysm (MA) turnover in mild non-proliferative diabetic retinopathy (NPDR) as predictors of progression to diabetic central-involved macular oedema (CIMO) in patients with type 2 diabetes mellitus (DM) in two different ethnic populations. METHODS: 205 patients with type 2 DM and mild NPDR were followed in a prospective observational study for 2 years or until development of CIMO, in two centres from different regions of the world...
April 26, 2018: British Journal of Ophthalmology
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