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British Journal of Ophthalmology

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https://www.readbyqxmd.com/read/28432114/intereye-asymmetry-in-bilateral-keratoconus-keratoconus-suspect-and-normal-eyes-and-its-relationship-with-disease-severity
#1
Mohammad Naderan, Mohammad Taher Rajabi, Parviz Zarrinbakhsh
BACKGROUND/AIM: To describe the intereye asymmetry in patients with keratoconus (KC), keratoconus suspect (KCS) and normal participants, and to evaluate the relationship between asymmetry and disease severity. METHODS: In this prospective observational comparative study, 446 patients with bilateral KC, 68 patients with bilateral KCS and 306 normal participants underwent topographic, keratometric and pachymetric evaluations by Pentacam as well as refractive and visual acuity examinations...
April 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28432113/automated-quantitative-characterisation-of-retinal-vascular-leakage-and-microaneurysms-in-ultra-widefield-fluorescein-angiography
#2
Justis P Ehlers, Kevin Wang, Amit Vasanji, Ming Hu, Sunil K Srivastava
Ultra-widefield fluorescein angiography (UWFA) is an emerging imaging modality used to characterise pathology in the retinal vasculature such as microaneurysms (MAs) and vascular leakage. Despite its potential value for diagnosis and disease surveillance, objective quantitative assessment of retinal pathology by UWFA is currently limited because it requires laborious manual segmentation by trained human graders. In this report, we describe a novel fully automated software platform, which segments MAs and leakage areas in native and dewarped UWFA images with retinal vascular disease...
April 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28432112/reduction-of-severe-visual-loss-and-complications-following-intra-arterial-chemotherapy-iac-for-refractory-retinoblastoma
#3
M Ashwin Reddy, Zishan Naeem, Catriona Duncan, Fergus Robertson, Jane Herod, Adam Rennie, Alki Liasis, Dorothy Ann Thompson, Mandeep Sagoo
BACKGROUND: Intra-arterial chemotherapy (IAC) for retinoblastoma has been documented as causing visual loss and ocular motility problems. A lack of safety data has precluded its acceptance in all centres. METHODS: Retrospective cohort study of patients with retinoblastoma from 2013 to 2015 who had a healthy foveola and relapsed following systemic chemotherapy. All required IAC. The correlation of complications with doses of melphalan +/- topotecan used and putative catheterisation complications was assessed...
April 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28432111/regional-vascular-density-visual-field-sensitivity-relationship-in-glaucoma-according-to-disease-severity
#4
Joong Won Shin, Jiyun Lee, Junki Kwon, Jaewan Choi, Michael S Kook
AIMS: To study whether there are global and regional relationships between peripapillary vascular density (pVD) assessed by optical coherence tomography angiography (OCT-A) and visual field (VF) mean sensitivity at different glaucoma stages. METHODS: Microvascular images and peripapillary retinal nerve fibre layer (pRNFL) thicknesses were obtained using a Cirrus OCT-A device in 91 glaucoma subjects. The pVD was measured at various spatial locations according to the Garway-Heath map, using a MATLAB software (The MathWorks, Natick, Massachusetts)...
April 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28432110/anterior-but-not-posterior-choroid-changed-before-and-during-valsalva-manoeuvre-in-healthy-chinese-a-ubm-and-ss-oct-study
#5
Fei Li, Kai Gao, Xingyi Li, Shida Chen, Wenbin Huang, Xiulan Zhang
PURPOSE: To determine if the anterior choroid is involved in ocular change during the Valsalva manoeuvre (VM). MATERIALS AND METHODS: Fifty-three healthy volunteers aged 18-65 years with normal visual field test results and no history of intraocular pressure (IOP) exceeding 21 mm Hg were recruited. Anterior and posterior choroidal changes before and during VM were recorded by ultrasound microscope and swept-source optical coherence tomography, respectively. Parameters of the anterior segment included ciliary body thickness (CBT0), thickness of the choroid at a distance of 4 mm from the root of the iris (CT4), anterior placement of the ciliary body (APCB) and trabecular-ciliary angle (TCA)...
April 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28432109/early-response-to-ranibizumab-predictive-of-functional-outcome-after-dexamethasone-for-unresponsive-diabetic-macular-oedema
#6
Maria Vittoria Cicinelli, Michele Cavalleri, Lea Querques, Alessandro Rabiolo, Francesco Bandello, Giuseppe Querques
PURPOSE: To analyse the effects of intravitreal dexamethasone implant in patients suffering from diabetic macular oedema (DME) on the basis of their visual and functional response to antivascular endothelial growth factor (VEGF) loading dose, in order to early shift to corticosteroids in poorly responding patients. DESIGN: Retrospective monocentric study. METHODS: Data of patients with diabetes shifted to 0.7 mg dexamethasone implant after three injections of ranibizumab (RNB) and followed-up to 12 months were reviewed...
April 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28416495/ultrastructural-study-of-peripheral-and-central-stroma-of-keratoconus-cornea
#7
Aljoharah Alkanaan, Robert Barsotti, Omar Kirat, Turki Almubrad, Adnan Khan, Saeed Akhtar
PURPOSE: Assess the lamellar organisation of the peripheral and central stroma of the keratoconus (KC) and normal cornea. METHODS: Five normal and three KC corneas were fixed in 2.5% glutaraldehyde and processed for electron microscopy. The ultrathin sections were observed under JEOL 1400 TEM, and digital images were taken with a bottom-mounted 11-megapixel Quamisa camera, using the iTEM software. Measurements of the lamellae were carried out using the iTEM software...
April 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28416494/long-term-clinical-course-of-normotensive-preperimetric-glaucoma
#8
Akira Sawada, Yusuke Manabe, Tetsuya Yamamoto, Chisato Nagata
AIMS: To evaluate the long-term clinical course of normotensive preperimetric glaucoma (PPG). METHODS: We retrospectively analysed 130 eyes of 130 patients initially diagnosed as having preperimetric normal tension glaucoma and followed these cases for at least 5 years with reliable visual field (VF) examinations by standard automated perimetry. When the VF defect (VFD) met Anderson-Patella's criteria on three or more consecutive examinations, and consistently met the criteria on subsequent examinations, we concluded that a glaucomatous VFD was present...
April 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28416493/phacoemulsification-compared-with-phacotrabeculectomy-surgery-a-within-person-observational-cohort-study
#9
Kazim Dhalla, Simon Cousens, Ian E Murdoch
AIM: To compare reduction in intraocular pressure (IOP) and gain in visual acuity (VA) following phacotrabeculectomy (PT) and phacoemulsification(phaco) in Tanzanian patients with primary open angle glaucoma(POAG). SETTING: CCBRT Hospital, Dar es Salaam, Tanzania. DESIGN: Within-person observational cohort study. METHODS: Within each patient, one eye had PT and the other phaco. Patients were followed for up to 5-1/2 years, and IOP and VA in each eye were assessed...
April 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28416492/intravitreal-triamcinolone-acetate-for-radiation-maculopathy-recalcitrant-to-high-dose-intravitreal-bevacizumab
#10
Richard I Kaplan, Sonal S Chaugule, Paul T Finger
BACKGROUND/AIMS: To evaluate the effect of adjuvant intravitreal triamcinolone acetonide (ITA) for radiation maculopathy (RM) recalcitrant to high-dose bevacizumab in patients with choroidal melanoma after plaque radiotherapy. METHODS: Eight eyes of eight patients with RM secondary to plaque radiotherapy for choroidal melanoma, recalcitrant to high-dose bevacizumab (3.0 mg) were retrospectively evaluated. Intravitreal injections of ITA (4 mg/0.1 mL) were performed at 4-week to 16-week intervals as an adjunct to continued bevacizumab therapy...
April 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28404670/intravitreal-dexamethasone-implant-in-radiation-induced-macular-oedema
#11
Luisa Frizziero, Raffaele Parrozzani, Sara Trainiti, Elisabetta Pilotto, Giacomo Miglionico, Serena Pulze, Edoardo Midena
AIMS: To evaluate the efficacy and duration of activity of a single intravitreal dexamethasone implant in patients affected by radiation maculopathy. METHODS: Thirteen consecutive eyes of 13 patients affected by radiation maculopathy secondary to eye irradiation for a primary uveal melanoma (Iodine-125 brachytherapy) and treated with a single intravitreal 0.7 mg dexamethasone implant were retrospectively evaluated. Each patient underwent full ophthalmological examination, including fluorescein angiography and spectral domain optical coherence tomography (SD-OCT), even in en-face modality...
April 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28404669/retinopathy-of-prematurity-screening-and-treatment-in-costa-rica
#12
Ana Catalina Tabarez-Carvajal, Milagro Montes-Cantillo, Kelly H Unkrich, Rupal H Trivedi, Mae Millicent Winfrey Peterseim
AIM: To determine the recent demographic data, risk factors and results of retinopathy of prematurity (ROP) screening and treatment in Costa Rica. METHODS: The medical records of all preterm infants meeting ROP screening criteria (≤34 weeks' gestational age (GA) or birth weight (BW) ≤1750g, and those determined at risk by neonatologists) in the national healthcare system, Costa Rica, January 2010-December 2014, were retrospectively reviewed. The numbers and percentages of infants with ROP, risk factors, percentage of patients treated and treatment outcomes were determined...
April 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28404668/nasalised-distribution-of-peripapillary-retinal-nerve-fibre-layers-in-large-discs
#13
Eun Jung Lee, Jong Chul Han, Changwon Kee
BACKGROUND: To describe the distribution pattern of the peripapillary retinal nerve fibre layer (RNFL) and major retinal vessel positions in patients with a large disc. METHODS: The medical records of patients with a large disc and those of normal controls were reviewed retrospectively. Comprehensive ophthalmic examinations including Cirrus HD-optical coherence tomography (OCT) and Heidelberg Retinal Tomography III (HRT III) were performed. We divided patients into two groups (large disc group and control group) using an HRT-measured disc size of 2...
April 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28404667/distinct-clinical-characteristics-of-atypical-optic-neuritis-with-seronegative-aquaporin-4-antibody-among-chinese-patients
#14
Huanfen Zhou, Quangang Xu, Shuo Zhao, Wei Wang, Junqing Wang, Zhiye Chen, Dahe Lin, Xiaoming Li, Chunxia Peng, Nanping Ai, Shihui Wei
OBJECTIVE: To evaluate the clinical features and prognosis of atypical optic neuritis (ON) with seronegative aquaporin-4 (AQP4) antibody in Chinese patients. METHODS: All patients with first or relapsing ON were recruited from the Neuro-ophthalmology Department of the Chinese People's Liberation Army General Hospital from January 2013 to December 2014 and assigned to one of three groups based on diagnosis: atypical ON, typical ON and neuromyelitis optica spectrum disorder (NMOSD)-ON...
April 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28404666/cardiovascular-medication-and-intraocular-pressure-results-from-the-gutenberg-health-study
#15
René Höhn, Alireza Mirshahi, Stefan Nickels, Andreas Schulz, Philipp S Wild, Maria Blettner, Norbert Pfeiffer
BACKGROUND: Intraocular pressure (IOP) is well known to be associated with blood pressure and other cardiovascular risk factors. The influence of systemic cardiovascular, in particular antihypertensive, medication on IOP is still controversial. This study analyses the association between the use of cardiovascular medications and IOP in a large European cohort. METHODS: The Gutenberg Health Study is a population-based, prospective,observational cohort study in mid-western Germany...
April 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28396340/myopic-glaucomatous-eyes-with-or-without-optic-disc-shape-alteration-a-longitudinal-study
#16
Junki Kwon, Kyung Rim Sung, Ji Min Park
AIMS: To compare the clinical courses of patients with myopic primary open angle glaucoma (POAG) with and without optic disc shape alterations. METHODS: In this longitudinal retrospective study, 146 eyes from 146 patients with myopic (axial length(AXL),>24 mm) POAG were classified according to optic disc shape alterations defined by optic disc tilt and/or rotation. Glaucomatous progression was determined by either serial optic disc/retinal nerve fibre layer photographs or visual field (VF) exams...
April 10, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28396339/poppers-legal-highs-with-questionable-contents-a-case-series-of-poppers-maculopathy
#17
Rebecca Rewbury, Edward Hughes, Robert Purbrick, Stephen Prior, Mark Baron
BACKGROUND: Poppers are volatile alkyl nitrite compounds that are inhaled to enhance sexual experience and for their psychoactive effects. A less well-known side effect is foveal maculopathy, which has emerged following changes in their chemical composition. It is unclear if certain individuals are more susceptible to retinal damage or if there is a relationship between pattern of inhalation and brands used. METHODS: A case series of 12 patients presenting to Sussex Eye Hospital, Brighton, with poppers-related visual impairment...
April 10, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28391239/retinal-detachment-surgery-in-western-australia-2000-2013-a-whole-population-study
#18
Siobhan Manners, Jonathon Q Ng, Anna Kemp-Casey, Kyle Chow, Chee-Yiong Kang, David B Preen
AIMS: To determine the background incidence rate of retinal detachment (RD) in Western Australia (WA) between 2000 and 2013, identify sociodemographic features associated with increased risk of incident RD and examine trends in surgical repair technique. METHODS: A whole-population retrospective observational study of all people in WA was carried out using linked hospital inpatient records. Cases of RD were identified using a combination of International Classification of Diseases, Ninth revision, Clinical Modification (ICD-9-CM) and ICD-10-AM (Australian modification) diagnosis and procedure codes from routinely collected hospital inpatient data provided by the WA Data Linkage Branch...
April 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28351927/factors-influencing-intraocular-pressure-corneal-thickness-and-corneal-biomechanics-after-congenital-cataract-surgery
#19
Amir Faramarzi, Sepehr Feizi, Ali Maghsoodlou
AIMS: This study aims to compare intraocular pressure (IOP), central corneal thickness (CCT) and corneal biomechanics among patients with aphakia, patients with primary and secondary pseudophakia and matched controls following congenital cataract surgery and to investigate the factors influencing these variables. METHODS: This study included 36 aphakic eyes, 47 primary pseudophakic eyes and 30 secondary pseudophakic eyes. Thirty-four normal eyes of matched volunteers were recruited for comparisons...
March 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28351926/epiblepharon-in-congenital-glaucoma-case-control-study
#20
Namju Kim, Yung Ju Yoo, Ho-Kyung Choung, Sang In Khwarg
BACKGROUND/AIMS: To assess the prevalence, clinical features and risk factors of lower lid epiblepharon among patients with congenital glaucoma. METHODS: Cross-sectional, observational, case-control study. Patients diagnosed with congenital glaucoma between August 1999 and November 2014 were included. Demographic and clinical characteristic data were collected. Age-matched normal controls were recruited form general population. Main outcome measures were the prevalence, laterality and factors associated with epiblepharon in patients with congenital glaucoma...
March 28, 2017: British Journal of Ophthalmology
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