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British Journal of Ophthalmology

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https://www.readbyqxmd.com/read/28729372/intraoperative-optical-coherence-tomography-compatible-surgical-instruments-for-real-time-image-guided-ophthalmic-surgery
#1
Justis P Ehlers, Atsuro Uchida, Sunil K Srivastava
Intraoperative optical coherence tomography (OCT) is a potentially transformational technology that is now commercially available to ophthalmic surgeons. Currently, the use of the technology is primarily limited to a 'stop and image' approach due to the lack of OCT compatibility with surgical instrumentation. In this report, we describe multiple OCT-compatible surgical instruments that were developed for various surgical needs, based on previous evaluation of potential surgical materials for optical features and physical properties...
July 20, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729371/geographic-atrophy-phenotype-identification-by-cluster-analysis
#2
Jordi Monés, Marc Biarnés
BACKGROUND/AIMS: To identify ocular phenotypes in patients with geographic atrophy secondary to age-related macular degeneration (GA) using a data-driven cluster analysis. METHODS: This was a retrospective analysis of data from a prospective, natural history study of patients with GA who were followed for ≥6 months. Cluster analysis was used to identify subgroups within the population based on the presence of several phenotypic features: soft drusen, reticular pseudodrusen (RPD), primary foveal atrophy, increased fundus autofluorescence (FAF), greyish FAF appearance and subfoveal choroidal thickness (SFCT)...
July 20, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729370/anterior-segment-optical-coherence-tomography-angle-and-vault-analysis-after-toric-and-non-toric-implantable-collamer-lens-v4c-implantation-in-patients-with-high-myopia
#3
Guillermo Garcia-De la Rosa, Andrew Olivo-Payne, Juan Carlos Serna-Ojeda, Maria Sandra Salazar-Ramos, Alejandro Lichtinger, Arturo Gomez-Bastar, Arturo Ramirez-Miranda, Alejandro Navas, Enrique O Graue-Hernandez
OBJECTIVE: To assess anterior segment changes, including iridocorneal angle and vault, after toric and non-toric implantable collamer lens (ICL) V4c (STAAR Surgical AG) implantation under different lighting conditions. METHODS: Longitudinal, prospective, case series. Patients with high myopia (>6 dioptres) underwent toric and non-toric ICL V4c implantation. Optical coherence tomography measurements were taken under different lighting conditions preoperatively and at 1 week and 1, 6 and 12 months of follow-up...
July 20, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729369/pigmentary-retinopathy-rod-cone-dysfunction-and-sensorineural-deafness-associated-with-a-rare-mitochondrial-trna-lys-m-8340g-a-gene-variant
#4
Jaidip S Gill, Steven A Hardy, Emma L Blakely, Sila Hopton, Andrea H Nemeth, Carl Fratter, Joanna Poulton, Robert W Taylor, Susan M Downes
BACKGROUND/AIM: The rare mitochondrial DNA (mtDNA) variant m.8340G>A has been previously reported in the literature in a single, sporadic case of mitochondrial myopathy. In this report, we aim to investigate the case of a 39-year-old male patient with sensorineural deafness who presented to the eye clinic with nyctalopia, retinal pigmentary changes and bilateral cortical cataracts. METHODS: The patient was examined clinically and investigated with autofluorescence, full-field electroretinography, electro-oculogram and dark adaptometry...
July 20, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729368/increased-stroke-risk-among-patients-with-open-angle-glaucoma-a-10-year-follow-up-cohort-study
#5
Tyler Hyungtaek Rim, Sang Yeop Lee, Hyoung Won Bae, Sung Soo Kim, Chan Yun Kim
BACKGROUND: Although several studies showed the association between stroke and open-angle glaucoma (OAG), there is still lack of longitudinal studies based on large populations. Therefore, in this study, we investigated the risk of stroke after OAG diagnosis over a 10-year follow-up period. METHODS: We performed a retrospective nationwide propensity score-matched cohort study. OAG and comparison groups were selected from a large database from the Korean National Health Insurance Service, comprising 1 025 340 random subjects...
July 20, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28724636/predictive-imaging-biomarkers-relevant-for-functional-and-anatomical-outcomes-during-ranibizumab-therapy-of-diabetic-macular-oedema
#6
Bianca S Gerendas, Sonja Prager, Gabor Deak, Christian Simader, Jan Lammer, Sebastian M Waldstein, Tadhg Guerin, Michael Kundi, Ursula Margarethe Schmidt-Erfurth
BACKGROUND/AIMS: The objective is to identify imaging biomarkers in optical coherence tomography predicting functional/anatomical outcomes in diabetic macular oedema (DMO). METHODS: The presented study is a post hoc analysis of the RESTORE/RESTORE-extension studies. Best-corrected visual acuity (BCVA) was analysed using general estimating equation models using treatment group/morphological features as predictor variables. In addition, linear multiple regression models analysed BCVA gain up to 12 and 36 months with BCVA/morphological baseline characteristics as independent predictor variables...
July 19, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28698242/abnormal-fixational-eye-movements-in-strabismus
#7
Fatema F Ghasia, Jorge Otero-Millan, Aasef G Shaikh
INTRODUCTION: Fixational saccades are miniature eye movements that constantly change the gaze during attempted visual fixation. Visually guided saccades and fixational saccades represent an oculomotor continuum and are produced by common neural machinery. Patients with strabismus have disconjugate binocular horizontal saccades. We examined the stability and variability of eye position during fixation in patients with strabismus and correlated the severity of fixational instability with strabismus angle and binocular vision...
July 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28698241/longitudinal-characterisation-of-function-and-structure-of-bietti-crystalline-dystrophy-report-on-a-novel-homozygous-mutation-in-cyp4v2
#8
Catherine M Lockhart, Travis B Smith, Paul Yang, Malini Naidu, Allan E Rettie, Abhinav Nath, Richard Weleber, Edward J Kelly
BACKGROUND: Bietti crystalline dystrophy (BCD) is a rare inherited disorder characterised by fine crystalline deposits in the corneal limbus and retinal posterior pole. In 2004, mutations in the CYP4V2 gene were identified as the cause of BCD. Here, we describe the report of a homozygous point mutation in a patient with BCD and provide detailed characterisation of functional and structural changes over 20 years. METHODS: At regular intervals, the patient underwent repeat ophthalmic evaluations...
July 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28689170/late-outcomes-of-gold-weights-and-platinum-chains-for-upper-eyelid-loading
#9
We Fong Siah, Sonali Nagendran, Petrina Tan, Syed Mustafa Ali Ahmad, Andre S Litwin, Raman Malhotra
AIM: To identify late outcomes of gold weights (GWs) and platinum chains (PCs) for upper eyelid loading in the management of lagophthalmos. METHODS: A retrospective case series of upper eyelid GWs and PCs at a single centre over a 10-year period (2004-2013). Two independent, blinded assessors graded standard photographs for any weight-related morbidity (poor upper eyelid contour, weight prominence and migration). RESULTS: Primary upper eyelid loading (high-tarsal technique) was performed in 154 eyelids of 136 patients (facial nerve palsy, n=99; non-paralytic, n=37)...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28689169/leber-congenital-amaurosis-early-onset-severe-retinal-dystrophy-clinical-features-molecular-genetics-and-therapeutic-interventions
#10
REVIEW
Neruban Kumaran, Anthony T Moore, Richard G Weleber, Michel Michaelides
Leber congenital amaurosis (LCA) and early-onset severe retinal dystrophy (EOSRD) are both genetically and phenotypically heterogeneous, and characterised clinically by severe congenital/early infancy visual loss, nystagmus, amaurotic pupils and markedly reduced/absent full-field electroretinograms. The vast genetic heterogeneity of inherited retinal disease has been established over the last 10 - 20 years, with disease-causing variants identified in 25 genes to date associated with LCA/EOSRD, accounting for 70-80% of cases, with thereby more genes yet to be identified...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28689168/systemic-diseases-in-patients-with-htlv-1-associated-uveitis
#11
Kumiko Nakao, Noriko Abematsu, Taiji Sakamoto
BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) carriers may develop severe systemic diseases, such as adult T cell leukaemia (ATL) or HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This study aims to investigate systemic diseases of HTLV-1 carriers who had developed HTLV-1-associated uveitis (HAU). METHODS: We investigated the occurrence of systemic diseases in 200 patients with HAU by performing a retrospective investigation of their medical records and examining the results of a postal survey...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28689167/the-interpretation-of-results-of-10-2-visual-fields-should-consider-individual-variability-in-the-position-of-the-optic-disc-and-temporal-raphe
#12
Fumi Tanabe, Chota Matsumoto, Allison M McKendrick, Sachiko Okuyama, Shigeki Hashimoto, Yoshikazu Shimomura
AIMS: To clarify the anatomical relation between the optic disc and temporal raphe and to examine how these are related to test points in the 10-2 visual field test pattern. SUBJECTS AND METHODS: For 22 eyes of volunteers with normal vision (+0.75 D spherical equivalent 7.88 D), a volume scan was used to obtain en-face images from a plane fitted to the inner limiting membrane using optical coherence tomography (OCT). The clearest en-face retinal nerve fibre (RNF) image was chosen for each subject and superimposed on fundus photographs using blood vessels for alignment...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28689166/ocular-surface-cytokine-profile-in-chronic-stevens-johnson-syndrome-and-its-response-to-mucous-membrane-grafting-for-lid-margin-keratinisation
#13
Srividya Gurumurthy, Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal, Narayanasamy Angayarkanni
BACKGROUND: To study the tear cytokine and the conjunctival and oral mucosal marker profile in chronic ocular Stevens-Johnson syndrome (SJS) and their alteration following mucous membrane grafting (MMG) for lid margin keratinisation (LMK). METHODS: In a 1-year prospective study, SJS cases (n=25) and age-matched/sex-matched healthy controls (n=25) were recruited. Tear specimen (Schirmer's strip), conjunctival and oral mucosal imprints were collected from controls and SJS cases pre-MMG and post-MMG (at first follow-up, n=17)...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28689165/tear-film-and-ocular-surface-assessment-in-psoriasis
#14
Emanuela Aragona, Laura Rania, Elisa Imelde Postorino, Alberto Interdonato, Roberta Giuffrida, Serafinella Patrizia Cannavò, Domenico Puzzolo, Pasquale Aragona
BACKGROUND: Psoriasis is a skin disease with also systemic involvement: its impact on the eye is not well established and often clinically underestimated. Aim of this study was to investigate the presence of ocular discomfort symptoms and of ocular surface changes in a population of patients with psoriasis. METHODS: For this cross-sectional, comparative study, 66 patients with psoriasis were subdivided according to the presence of arthritis and to the use of biological therapy...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28659392/change-in-vision-related-quality-of-life-and-influencing-factors-in-asians-receiving-treatment-for-neovascular-age-related-macular-degeneration
#15
Eva K Fenwick, Gemmy Chui Ming Cheung, Alfred Tl Gan, Gavin Tan, Shu Yen Lee, Doric Wong, Ian Yeo, Ranjana Mathur, Tien Y Wong, Ecosse L Lamoureux
AIM: To assess the change in vision-related quality of life (VRQoL) after treatment for neovascular age-related macular degeneration (nAMD) and factors influencing this change in an Asian population. METHODS: In this longitudinal study, 116 patients (mean age±SD=66.5±9.9 years; 59.5% male) who underwent treatment for nAMD were recruited from a tertiary eye centre in Singapore. Best-corrected visual acuity (BCVA) and the Impact of Vision Impairment (IVI) questionnaire were evaluated at baseline and month 12...
June 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28659391/primary-enucleation-for-group-d-retinoblastoma-in-the-era-of-systemic-and-targeted-chemotherapy-the-price-of-retaining-an-eye
#16
Ido D Fabian, Andrew W Stacey, Kenneth C Johnson, Tanzina Chowdhury, Catriona Duncan, M Ashwin Reddy, Mandeep S Sagoo
BACKGROUND: Chemotherapy is increasingly used as primary treatment for group D retinoblastoma, whereas primary enucleation is considered to have a diminishing role. This study aimed to compare the management course, including number of examinations under anaesthesia (EUAs), of group D patients treated by enucleation versus chemotherapy. METHODS: A retrospective analysis of 92 group D patients, of which 40 (37 unilateral) underwent primary enucleation and 52 (17 unilateral) were treated with intravenous chemotherapy...
June 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28659390/risk-of-bias-assessment-of-randomised-controlled-trials-in-high-impact-ophthalmology-journals-and-general-medical-journals-a-systematic-review
#17
REVIEW
Lazar Joksimovic, Robert Koucheki, Marko Popovic, Yusuf Ahmed, Matthew B Schlenker, Iqbal Ike K Ahmed
Evidence-based treatments in ophthalmology are often based on the results of randomised controlled trials. Biased conclusions from randomised controlled trials may lead to inappropriate management recommendations. This systematic review investigates the prevalence of bias risk in randomised controlled trials published in high-impact ophthalmology journals and ophthalmology trials from general medical journals. Using Ovid MEDLINE, randomised controlled trials in the top 10 high-impact ophthalmology journals in 2015 were systematically identified and critically appraised for the prevalence of bias risk...
June 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28659389/diagnosis-of-lyme-associated-uveitis-value-of-serological-testing-in-a-tertiary-centre
#18
Alexia Bernard, Laurent Kodjikian, Amro Abukhashabh, Chantal Roure-Sobas, Andre Boibieux, Philippe Denis, Christiane Broussolle, Pascal Seve
AIMS: To determine the frequency and clinical presentation of Lyme disease in patients with uveitis and to assess the value of Borrelia burgdorferi serological testing. METHODS: Retrospective study on all patients with uveitis who were referred to our tertiary hospital were serologically tested for Lyme in our laboratory between 2003 and 2016. Screening consisted of determining B. burgdorferi serum IgG and IgM by ELISA method. The patient's serology was considered as positive if the ELISA-positive result in IgM and/or IgG was confirmed by an immunoblot positive in IgM and/or IgG...
June 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28659388/incidence-risk-factors-and-management-of-intractable-diplopia
#19
David Newsham, Anna R O'Connor, Richard A Harrad
AIMS: There is a paucity of literature concerning intractable diplopia. The aims of this study were to determine the incidence of intractable diplopia in the UK, identify the causes and any associated risk factors, establish how cases are managed and if the treatment is successful and tolerated. METHODS: A 1-year prospective observational study was undertaken via the British Ophthalmological Surveillance Unit (BOSU). This involved implementation of a reporting mechanism, which then triggered distribution of an incident questionnaire to explore clinical details concerning each case and a follow-up questionnaire 6 months later to explore how the case had been managed...
June 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28655731/ultra-low-dose-intravitreal-bevacizumab-for-the-treatment-of-retinopathy-of-prematurity-a-case-series
#20
Roxane J Hillier, Alan J Connor, Ayad E Shafiq
BACKGROUND: Intravitreal bevacizumab (IVB) has emerged as an effective treatment modality for the management of retinopathy of prematurity (ROP) where the disease is severe and posterior. Despite evidence of systemic vascular endothelial growth factor suppression and concerns about how this might affect the developing neonate, the optimal dose is unknown to date. We report our experience of using ultra-low-dose (0.16 mg) IVB, one-quarter of the 'standard' dose that has widely been reported in the treatment of ROP...
June 27, 2017: British Journal of Ophthalmology
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