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British Journal of Ophthalmology

Aniruddha Kishandutt Agarwal, Kanika Aggarwal, Ramanuj Samanta, Archana Angrup, Manisha Biswal, Pallab Ray, Mohit Dogra, Deeksha Katoch, Reema Bansal, Ramandeep Singh, Mangat R Dogra, Vishali Gupta
PURPOSE: To study features, management and outcomes of cluster endophthalmitis following intravitreal bevacizumab (BCZ) injection in North India. METHODS: In this retrospective study, 28 patients (23 men) (mean age of 59.07±13 years) who received intravitreal injection of BCZ were included. Demographic details, best corrected visual acuity (BCVA), clinical features, microbiological findings and management of patients who developed endophthalmitis after injection of contaminated BCZ injections were reviewed...
November 12, 2018: British Journal of Ophthalmology
Hee Kyung Yang, Sang Jun Park, Seong Jun Byun, Kyu Hyung Park, Jeong-Whun Kim, Jeong-Min Hwang
BACKGROUND/AIMS: To determine whether the development of non-arteritic anterior ischaemic optic neuropathy (NAION) is increased among patients newly diagnosed with obstructive sleep apnoea (OSA) in a large general population. METHODS: A 12-year nationwide, population-based, retrospective cohort study including 1 025 340 beneficiaries in the 2002-2013 Korean National Health Insurance Service database was performed. We identified 919 patients newly diagnosed with OSA aged ≥40 years and matched 9190 non-OSA controls using estimated propensity scores in reference to age, sex, demographics, comorbidities and co-medications...
November 9, 2018: British Journal of Ophthalmology
Ji Eun Lee, Hee Kyung Yang, Jae Hyoung Kim, Jeong-Min Hwang
AIMS: To determine the structure-function relationship between the degree of superior oblique (SO) hypoplasia and ocular motility in unilateral SO palsy. METHODS: A total of 166 patients with unilateral SO palsy were divided into three groups based on their aetiology and high-resolution MRI findings by an in-plane resolution of 0.25  mm: (1) congenital SO palsy and unilateral trochlear nerve agenesis (absent group, n=79), (2) congenital SO palsy and symmetric trochlear nerves on both sides (present group, n=40) and (3) acquired SO palsy (acquired group, n=47) who all had symmetric trochlear nerves on both sides...
November 8, 2018: British Journal of Ophthalmology
Allison Low, Ambar Faridi, Kavita V Bhavsar, Glenn C Cockerham, Michele Freeman, Rochelle Fu, Robin Paynter, Karli Kondo, Devan Kansagara
Intravitreal antivascular endothelial growth factor (VEGF) agents are widely used to treat ocular conditions but the benefits and harms of these treatments are uncertain. We conducted a systematic review to compare the effects of aflibercept, bevacizumab and ranibizumab on best-corrected visual acuity (BCVA) changes, quality of life and ocular or systemic adverse events in patients with neovascular age-related macular degeneration (NVAMD), diabetic macular oedema (DME) and central or branch retinal vein occlusion (RVO)...
November 8, 2018: British Journal of Ophthalmology
Vinay Nangia, Jost B Jonas, Ronnie George, Vijaya Lingam, Leon Ellwein, Maria Vittoria Cicinelli, Aditi Das, Seth R Flaxman, Jill E Keeffe, John H Kempen, Janet Leasher, Hans Limburg, Kovin Naidoo, Konrad Pesudovs, Serge Resnikoff, Alexander J Silvester, Nina Tahhan, Hugh R Taylor, Tien Y Wong, Rupert R A Bourne
BACKGROUND: To assess prevalence and causes of vision loss in Central and South Asia. METHODS: A systematic review of medical literature assessed the prevalence of blindness (presenting visual acuity<3/60 in the better eye), moderate and severe vision impairment (MSVI; presenting visual acuity <6/18 but ≥3/60) and mild vision impairment (MVI; presenting visual acuity <6/12 and ≥6/18) in Central and South Asia for 1990, 2010, 2015 and 2020. RESULTS: In Central and South Asia combined, age-standardised prevalences of blindness, MSVI and MVI in 2015 were for men and women aged 50+years, 3...
November 8, 2018: British Journal of Ophthalmology
Katie M Williams, Eva Kraphol, Ekaterina Yonova-Doing, Pirro G Hysi, Robert Plomin, Christopher J Hammond
PURPOSE: Myopia is an increasingly prevalent condition globally. A greater understanding of contemporaneous, early life factors associated with myopia risk is urgently required, particularly in younger onset myopia as this correlates with higher severity and increased complications in adult life. METHODS: Analysis of a subset of the longitudinal, UK-based Twins Early Development Study (n=1991) recruited at birth between 1994 and 1996. Subjective refraction was obtained from the twin's optometrists; mean age 16...
November 6, 2018: British Journal of Ophthalmology
Mohamed Dirani, Jonathan G Crowston, Tien Y Wong
No abstract text is available yet for this article.
November 6, 2018: British Journal of Ophthalmology
Ilse Mombaerts, Elodie Witters
BACKGROUND/AIMS: Although a Jones tube is considered the mainstay for epiphora in patients with total blockage of the canalicular system, it has been discouraged in children for reasons of inadequate self-care and maintenance. The purpose of this study is to compare the long-term outcome of Jones tube surgery in paediatric versus adult patients. METHODS: Retrospective, interventional case series of a single academic institution. The medical records of all children (≤16 years old) and adults (>16 years old) who underwent conjunctivorhinostomy with placement of a 130° angled extended Jones tube were reviewed...
November 5, 2018: British Journal of Ophthalmology
Jayme R Vianna, Ziad Butty, Lucas A Torres, Glen P Sharpe, Donna M Hutchison, Lesya M Shuba, Marcelo T Nicolela, Balwantray C Chauhan
BACKGROUND/AIMS: To determine the effect of glaucoma on outer retinal layer thickness in eyes with horizontal hemifield visual field (VF) defects. METHODS: We conducted a cross-sectional study in glaucomatous eyes with repeatable (in three or examinations) horizontal hemifield VF (programme 24-2) defect defined as: all five nasal VF locations immediately either above or below the horizontal midline abnormal in the pattern deviation plot with p<0.5%; no mirror-image adjacent 5 VF locations abnormal in the pattern deviation plot and no non-edge VF locations in the non-affected hemifield abnormal in the pattern deviation plot with p<1%...
November 1, 2018: British Journal of Ophthalmology
Rohan W Essex, Vuong Nguyen, Vincent Daien, Sarah Steinmann, Richard Walton, Mark C Gillies, Daniel Barthelmes
OBJECTIVE: To compare the outcomes of trainee-led and specialist-led management of neovascular age-related macular degeneration. DESIGN: Prospective multicentre registry-based observational study. SETTING: Ophthalmology training centres in Australia and Europe where both trainee-led and specialist-led models of care coexist. PARTICIPANTS: Treatment-naïve eyes with neovascular age-related macular degeneration and at least 12 months follow-up...
November 1, 2018: British Journal of Ophthalmology
Simon K H Szeto, Raymond Wong, Jerry Lok, Fangyao Tang, Zihan Sun, Tiffany Tso, Thomas C H Lam, Clement C Tham, Danny S Ng, Carol Y Cheung
AIMS: To evaluate the performance of ultrawide field scanning laser ophthalmoscopy (UWF-SLO) for assessing diabetic retinopathy (DR) and diabetic macular oedema (DME) in a Chinese population, compared with clinical examination. METHODS: This is a retrospective cohort study. A series of 322 eyes from 164 patients with DM were included. Each patient underwent both dilated fundal examination with DR and DME grading by retina specialist and non-mydriatic 200° UWF-SLO (Daytona, Optos, Dunfermline, UK)...
October 31, 2018: British Journal of Ophthalmology
Nikolas J S London, Richard S Kaiser, Mohammed Ali Khan, Rayan A Alshareef, Mohammed Khuthaila, Abtin Shahlaee, Anthony Obeid, Vanessa A London, Francis Char DeCroos, Omesh P Gupta, Jason Hsu, James F Vander, Marc J Spirn, Carl D Regillo
PURPOSE: To examine the effect of low-dose, oral isotretinoin in lowering the risk of proliferative vitreoretinopathy (PVR) following rhegmatogenous retinal detachment (RRD) repair. METHODS: Prospective, open label, dual-cohort study with pathology-matched historical controls. The prospective experimental arms included two cohorts, composed of 51 eyes with recurrent PVR-related RRD and 58 eyes with primary RRD associated with high-risk features for developing PVR...
October 31, 2018: British Journal of Ophthalmology
Jasmine H Francis, Federica Catalanotti, Jonathan Landa, Christopher A Barker, Alexander N Shoushtari, David H Abramson
BACKGROUND: Metastases to the liver are often the first finding in patients with uveal melanoma with extraocular disease, but little has been published on the utility of staging MRI at initial diagnosis. We aimed to evaluate the proportion of abnormal hepatic findings on baseline MRI and accuracy of MRI in patients with newly diagnosed uveal melanoma. METHODS: This is a single-centre, retrospective, institutional review board-approved study of 145 consecutive patients diagnosed with uveal melanoma, at Memorial Sloan Kettering Cancer Center between 2004 and 2016, who had staging MRI within 1  month of diagnosis...
October 31, 2018: British Journal of Ophthalmology
Xiao-Yi Qin, Zhe-Hao Jin, You-Pei Wang, Zong-Duan Zhang
BACKGROUND/AIMS: To describe the clinicopathological and immunohistochemical characteristics of 10 patients representing a new entity of benign conjunctival myxoid stromal tumours. METHODS: Retrospective review of clinical findings, histopathological and immunohistochemical studies identified 10 cases of low-grade conjunctival myxoid stromal tumours. Specimens were routinely processed and stained with H&E. Immunohistochemical stains for CD34, CD68, vimentin, S100, smooth muscle actin (SMA), myosin, desmin, actin, Bcl-2 and Ki-67 were performed...
October 31, 2018: British Journal of Ophthalmology
Chikako Harada, Atsuko Kimura, Xiaoli Guo, Kazuhiko Namekata, Takayuki Harada
Glaucoma is one of the leading causes of vision loss in the world. Currently, pharmacological intervention for glaucoma therapy is limited to eye drops that reduce intraocular pressure (IOP). Recent studies have shown that various factors as well as IOP are involved in the pathogenesis of glaucoma, especially in the subtype of normal tension glaucoma. To date, various animal models of glaucoma have been established, including glutamate/aspartate transporter knockout (KO) mice, excitatory amino acid carrier 1 KO mice, optineurin E50K knock-in mice, DBA/2J mice and experimentally induced models...
October 26, 2018: British Journal of Ophthalmology
Junting Huang, Jiewen Fu, Shangyi Fu, Lisha Yang, Kailai Nie, Chengxia Duan, Jingliang Cheng, Yumei Li, Hongbin Lv, Rui Chen, Longqian Liu, Junjiang Fu
BACKGROUND/AIM: Gyrate atrophy of the choroid and retina (GACR) is an extremely rare autosomal recessive inherited disorder characterised by progressive vision loss. To identify the disease-causing gene in a consanguineous Chinese pedigree with GACR, we aimed to accurately diagnose patients with GACR through a combination of next-generation sequencing (NGS) genetic diagnosis, clinical imaging and amino acid metabolic analysis. METHODS: A consanguineous Chinese pedigree with GACR, including two patients, was recruited and a comprehensive ophthalmological evaluation was performed...
October 26, 2018: British Journal of Ophthalmology
Jonathan E Lu, Jasmine H Francis, Ira J Dunkel, Carol L Shields, Michael D Yu, Jesse L Berry, Kaitlin Kogachi, Alison H Skalet, Audra K Miller, Pranav R Santapuram, Anthony B Daniels, David H Abramson
BACKGROUND/AIMS: Enucleation for retinoblastoma is performed less often in the past decade due to increasingly widespread alternative therapies, but enucleation remains an important option. There is a paucity of reports on the current incidence of metastases and metastatic deaths in unilateral retinoblastoma from US centres. METHODS: Retrospective chart review at five tertiary retinoblastoma centres in the USA for unilateral retinoblastoma patients treated with primary enucleation, 2007-2017, with <u>></u>1 year of follow-up or treatment failure...
October 25, 2018: British Journal of Ophthalmology
Daniel Shu Wei Ting, Louis R Pasquale, Lily Peng, John Peter Campbell, Aaron Y Lee, Rajiv Raman, Gavin Siew Wei Tan, Leopold Schmetterer, Pearse A Keane, Tien Yin Wong
Artificial intelligence (AI) based on deep learning (DL) has sparked tremendous global interest in recent years. DL has been widely adopted in image recognition, speech recognition and natural language processing, but is only beginning to impact on healthcare. In ophthalmology, DL has been applied to fundus photographs, optical coherence tomography and visual fields, achieving robust classification performance in the detection of diabetic retinopathy and retinopathy of prematurity, the glaucoma-like disc, macular oedema and age-related macular degeneration...
October 25, 2018: British Journal of Ophthalmology
Tadanobu Yoshikawa, Kenji Obayashi, Kimie Miyata, Tetsuo Ueda, Norio Kurumatani, Keigo Saeki, Nahoko Ogata
BACKGROUND: Glaucoma may cause physiological and behavioural circadian misalignment because of the loss of intrinsically photosensitive retinal ganglion cells, the primary receptors of environmental light. Although studies have suggested a high prevalence of depression in patients with glaucoma, it is unclear whether the association is independent of the light exposure profiles as an important confounding factor. METHODS: In this cross-sectional study of a community-based cohort of 770 elderly individuals (mean age, 70...
October 25, 2018: British Journal of Ophthalmology
Eva K Fenwick, Ryan E K Man, Alfred Tau Liang Gan, Neelam Kumari, Charlene Wong, Amudha Aravindhan, Preeti Gupta, Jie Jin Wang, Paul Mitchell, Tien Yin Wong, Ching-Yu Cheng, Ecosse Luc Lamoureux
BACKGROUND/AIMS: To assess the independent impact of diabetic retinopathy (DR) on three domains of vision-related quality of life (VRQoL) in a Chinese Singapore population. METHODS: The Singapore Chinese Eye Study (n=3353; 2009-2011) was a population-based, prospective, cross-sectional study conducted at the Singapore Eye Research Institute. The study population included 292 adults with diabetes, with and without DR. DR (better eye) was categorised as presence and absence of any DR; severity of DR (no vision-threatening DR (VTDR); severe non-proliferative DR (NPDR); PDR and/or clinically significant macular oedema and VTDR)...
October 25, 2018: British Journal of Ophthalmology
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