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British Journal of Ophthalmology

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https://www.readbyqxmd.com/read/28546151/comparison-of-intraocular-pressure-during-the-application-of-a-liquid-patient-interface-femto-ldv-z8-for-femtosecond-laser-assisted-cataract-surgery-using-two-different-vacuum-levels
#1
Martina Ebner, Siegfried Mariacher, Kai Januschowski, Katrin Boden, Anna-Maria Seuthe, Peter Szurman, Karl Thomas Boden
BACKGROUND: To evaluate intraocular pressure (IOP) using the application of a novel liquid patient interface for femtosecond laser-assisted cataract surgery with the FEMTO LDV Z8. METHODS: IOP was evaluated in enucleated porcine eyes prior, during and after the application of the Femto LDV Z8 liquid patient interface (Ziemer Ophthalmic Systems, Switzerland) using intracameral cannulation (n=20), intravitreal cannulation (n=20), rebound tonometry (n=20) and indentation tonometry (n=20)...
May 25, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546150/six-year-outcomes-of-antivascular-endothelial-growth-factor-monotherapy-for-polypoidal-choroidal-vasculopathy
#2
Taiichi Hikichi
OBJECTIVE: To evaluate the 6-year outcomes of anti-VEGF (vascular endothelial growth factor) monotherapy for polypoidal choroidal vasculopathy (PCV). METHODS: The charts of 66 eyes of 66 patients with newly diagnosed, symptomatic, treatment-naive PCV were reviewed retrospectively. All patients were treated with 0.5 mg intravitreal ranibizumab (IVR) injections for 3 months followed by as-needed reinjections based on monthly examinations until 3 years after the first IVR injection...
May 25, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546149/progression-of-lamellar-hole-associated-epiretinal-proliferation-and-retinal-changes-during-long-term-follow-up
#3
Denise Compera, Ricarda G Schumann, Matteo G Cereda, Alessandra Acquistapace, Viviane Lita, Siegfried G Priglinger, Giovanni Staurenghi, Ferdinando Bottoni
PURPOSE: To report on progression of lamellar hole-associated epiretinal proliferation (LHEP) in eyes with lamellar macular holes (LMH) using spectral-domain optical coherence tomography (SD-OCT), and to correlate with intraretinal changes and visual function. METHODS: From a retrospectively reviewed series of 167 eyes with non-full-thickness macular holes, we exclusively included a subgroup of 34 eyes with LMH and LHEP by SD-OCT evaluation. In these eyes, area of LHEP, intraretinal changes of defect diameter, central retinal thickness, defects of the ellipsoid zone and occurrence of a contractive epiretinal membrane were analysed...
May 25, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28500230/conjunctival-lymphangiectasia-associated-with-classic-fabry-disease
#4
Melanie D Sivley, Eric L Wallace, David G Warnock, William J Benjamin
BACKGROUND: Fabry disease (FD) is a treatable multisystem disease caused by a defect in the alpha-galactosidase gene. Ocular signs of FD, including corneal verticillata, are among the earliest diagnostic findings. Conjunctival lymphangiectasia (CL) has not previously been associated with FD. METHODS: We examined the eyes of a cohort of 13 adult patients, eight men and five women, with documented classic FD, all treated with enzyme replacement therapy (ERT) at the University of Alabama at Birmingham between February 2014 and April 2015...
May 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28495907/interdevice-comparison-of-retinal-sensitivity-assessments-in-a-healthy-population-the-centervue-maia-and-the-nidek-mp-3-microperimeters
#5
Siva Balasubramanian, Akihito Uji, Jianqin Lei, Swetha Velaga, Muneeswar Nittala, SriniVas Sadda
BACKGROUND: To compare and correlate the retinal sensitivity measurements obtained with Nidek Microperimetry-3 (MP-3) and the CenterVue Macular Integrity Assessment (MAIA) microperimeters among healthy subjects. METHODS: In this prospective comparative study, 31 eyes of 23 subjects underwent complete ophthalmological examination including retinal sensitivity assessments using two microperimeters, the MP-3 (Nidek Technologies) and the MAIA (CenterVue). The mean retinal sensitivity (dB) and its corresponding luminance (asb) and contrast (log units) were analysed between the two instruments...
May 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28495906/emergency-corneal-grafting-in-the-uk-a-6-year-analysis-of-the-uk-transplant-registry
#6
Parwez Hossain, Abdo Karim Tourkmani, Dimitri Kazakos, Mark Jones, David Anderson
BACKGROUND: Corneal graft (CG) surgery is the most common and successful tissue transplant worldwide. A small and important group of patients are operated in emergency situations, typically to save a perforated eye. Our knowledge of the indications and outcomes of emergency corneal graft (eCG) is limited. METHODS: Retrospective, multifactorial analysis of all CGs registered by the UK Transplant Service from April 1999 to March 2005. RESULTS: A total of 12 976 CGs were performed...
May 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28495905/long-term-outcomes-of-the-boston-type-i-keratoprosthesis-in-eyes-with-previous-herpes-simplex-virus-keratitis
#7
Melinda Fry, Carolina Aravena, Fei Yu, Jaffer Kattan, Anthony J Aldave
PURPOSE: To report the long-term outcomes of the Boston type I keratoprosthesis (Kpro) in eyes with prior herpes simplex virus (HSV) keratitis. METHODS: Retrospective review of all Kpro procedures performed by a single surgeon from 1 May 2004 to 1 January 2015. RESULTS: 13 of 173 Kpro procedures were performed in 11 eyes with prior HSV keratitis. There was not a significant difference in the percentage of eyes with and without prior HSV keratitis with preoperative (9% vs 8%, p=1...
May 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28495904/assessing-total-retinal-blood-flow-in-diabetic-retinopathy-using-multiplane-en-face-doppler-optical-coherence-tomography
#8
Alex D Pechauer, Thomas S Hwang, Ahmed M Hagag, Liang Liu, Ou Tan, Xinbo Zhang, Maria Parker, David Huang, David J Wilson, Yali Jia
AIM: To assess total retinal blood flow (TRBF) in diabetic retinopathy (DR) using multiplane en face Doppler optical coherence tomography (OCT). METHODS: A 70 kHz spectral-domain OCT system scanned a 2×2 mm area centred at the optic disc of the eyes with DR and healthy participants. The multiplane en face Doppler OCT algorithm generated a three-dimensional volumetric data set consisting of 195 en face planes. The TRBF was calculated from the maximum flow values of each branching retinal vein at an optimised en face plane...
May 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28490427/effect-of-acute-intraocular-pressure-elevation-on-the-minimum-rim-width-in-normal-ocular-hypertensive-and-glaucoma-eyes
#9
Sourabh Sharma, Tin A Tun, Mani Baskaran, Eray Atalay, Sri Gowtham Thakku, Zhang Liang, Dan Milea, Nicholas G Strouthidis, Tin Aung, Michael Ja Girard
BACKGROUND: To estimate and compare changes in the Bruch's membrane opening-minimum rim width (BMO-MRW) and area in normal, ocular hypertensive and glaucoma eyes following acute elevations in intraocular pressure (IOP). METHODS: The optic nerve heads (ONHs) of 104 subjects (31 normals, 20 ocular hypertension (OHT) and 53 with primary glaucoma) were imaged using Spectral-domain optical coherence tomography (OCT; Spectralis, Heidelberg Engineering, Germany). IOP was raised twice by applying a force (0...
May 10, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28487377/the-uk-diabetic-retinopathy-electronic-medical-record-uk-dr-emr-users-group-report-2-real-world-data-for-the-impact-of-cataract-surgery-on-diabetic-macular-oedema
#10
Alastair K Denniston, Usha Chakravarthy, Haogang Zhu, Aaron Y Lee, David P Crabb, Adnan Tufail, Clare Bailey, Toks Akerele, Sahar Al-Husainy, Christopher Brand, Louise Downey, Alan Fitt, Rehna Khan, Vineeth Kumar, Aires Lobo, Sajjad Mahmood, Kaveri Mandal, Martin Mckibbin, Geeta Menon, Salim Natha, Jong Min Ong, Marie D Tsaloumas, Atul Varma, Elizabeth Wilkinson, Robert L Johnston, Catherine A Egan
AIM: To assess the rate of 'treatment-requiring diabetic macular oedema (DMO)' in eyes for the two  years before and after cataract surgery. METHODS: Multicentre national diabetic retinopathy (DR) database study with anonymised data extraction across 19 centres from an electronic medical record system. INCLUSION CRITERIA: eyes undergoing cataract surgery in patients with diabetes with no history of DMO prior to study start. The minimum dataset included: age, visual acuity (all time-points), injection episodes, timing of cataract surgery and ETDRS grading of retinopathy and maculopathy...
May 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28487376/visual-and-ocular-motor-function-in-the-atypical-form-of-neurodegeneration-with-brain-iron-accumulation-type-i
#11
Joana Jesus-Ribeiro, Cláudia Farinha, Margarida Amorim, Anabela Matos, Aldina Reis, João Lemos, Miguel Castelo-Branco, Cristina Januário
BACKGROUND/AIMS: Neurodegeneration with brain iron accumulation (NBIA) type I is a rare disease that can be divided into a classical or atypical variant, according to age of onset and clinical pattern. Neuro-ophthalmological involvement has been documented in the classical variant but only anecdotically in the atypical variant. We sought to describe the visual and ocular motor function in patients with atypical form of NBIA type I. METHODS: Cross-sectional study, including patients with genetically confirmed NBIA type I and classified as atypical variant, who underwent ophthalmological examination with best corrected visual acuity (BCVA), optical coherence tomography (OCT), fundus autofluorescence (FAF), electroretinography (ERG), visual evoked potentials (VEP) and video-oculography...
May 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28478396/uk-amd-dr-emr-report-ix-comparative-effectiveness-of-predominantly-as-needed-prn-ranibizumab-versus-continuous-aflibercept-in-uk-clinical-practice
#12
Aaron Y Lee, Cecilia S Lee, Catherine A Egan, Clare Bailey, Robert L Johnston, Salim Natha, Robin Hamilton, Rehna Khan, Sahar Al-Husainy, Christopher Brand, Toks Akerele, Martin Mckibbin, Louise Downey, Adnan Tufail
AIMS: To compare the effectiveness of continuous aflibercept versus pro re nata (PRN) ranibizumab therapy for neovascular age-related macular degeneration (nAMD). METHODS: Multicentre, national electronic medical record (EMR) study on treatment naive nAMD eyes undergoing PRN ranibizumab or continuous (fixed or treat and extend (F/TE)) aflibercept from 21 UK hospitals. Anonymised data were extracted, and eyes were matched on age, gender, starting visual acuity (VA) and year of starting treatment...
May 6, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28478395/outcomes-of-penetrating-keratoplasty-in-congenital-hereditary-endothelial-dystrophy
#13
Hamed AlArrayedh, Louis Collum, Conor C Murphy
BACKGROUND/AIM: To report the outcome of penetrating keratoplasty (PKP) in Irish patients with congenital hereditary endothelial dystrophy (CHED). METHODS: A retrospective case series review of patients with CHED who underwent PKP was conducted. The outcomes of PKP in 14 patients with CHED at the Royal Victoria Eye and Ear Hospital in Dublin from 1978 to 2013 were described following case note review. The main outcome measures were best-corrected visual acuity (BCVA) and graft survival...
May 6, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28478394/safety-and-efficacy-of-a-low-cost-glaucoma-drainage-device-for-refractory-childhood-glaucoma
#14
Sushmita Kaushik, Pankaj Kataria, Srishti Raj, Surinder Singh Pandav, Jagat Ram
BACKGROUND: To evaluate the safety and efficacy of a low-cost glaucoma drainage device (GDD), Aurolab aqueous drainage implant (AADI), similar in design to the Baerveldt glaucoma implant (BGI), in refractory childhood glaucoma. METHODS: This prospective interventional study was conducted in a tertiary care postgraduate teaching institute. Children aged <16 years with uncontrolled intraocular pressure (IOP) refractory to medical treatment and considered at high risk of failure following trabeculectomy were recruited...
May 6, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28455280/-the-patient-is-speaking-discovering-the-patient-voice-in-ophthalmology
#15
REVIEW
Samera Dean, Jonathan M Mathers, Melanie Calvert, Derek G Kyte, Dolores Conroy, Annie Folkard, Sue Southworth, Phil Murray, Alastair K Denniston
Eye disease can be devastating. The most feared impact is sight loss, but in a number of ophthalmic conditions, there can be wide-ranging systemic, psychological, emotional and social effects of both the disease and its treatment. External tests of visual function, such as visual acuity, are inadequate to understand the overall impact of ophthalmic disease on a patient's functional vision or daily life. This can lead to a discordance between the patient's priorities and perspective on the one hand and the efforts of clinicians and other stakeholders on the other hand...
April 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28450381/investigating-the-usefulness-of-a-cluster-based-trend-analysis-to-detect-visual-field-progression-in-patients-with-open-angle-glaucoma
#16
Shuichiro Aoki, Hiroshi Murata, Yuri Fujino, Masato Matsuura, Atsuya Miki, Masaki Tanito, Shiro Mizoue, Kazuhiko Mori, Katsuyoshi Suzuki, Takehiro Yamashita, Kenji Kashiwagi, Kazunori Hirasawa, Nobuyuki Shoji, Ryo Asaoka
BACKGROUND/AIMS: To investigate the usefulness of the Octopus (Haag-Streit) EyeSuite's cluster trend analysis in glaucoma. METHODS: Ten visual fields (VFs) with the Humphrey Field Analyzer (Carl Zeiss Meditec), spanning 7.7 years on average were obtained from 728 eyes of 475 primary open angle glaucoma patients. Mean total deviation (mTD) trend analysis and EyeSuite's cluster trend analysis were performed on various series of VFs (from 1st to 10th: VF1-10 to 6th to 10th: VF6-10)...
April 27, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28450380/in-vivo-confocal-microscopy-and-tear-cytokine-analysis-in-post-lasik-ectasia
#17
Natasha Kishore Pahuja, Rohit Shetty, Rashmi Deshmukh, Anupam Sharma, Rudy M M A Nuijts, Vishal Jhanji, Swaminathan Sethu, Arkasubhra Ghosh
AIM: Corneal keratectasia is one of the complications associated with laser in situ keratomileusis (LASIK) that results in vision impairment. The pathogenesis of post-LASIK ectasia (PLE) remains underexplored. We report the tear cytokine profile and in vivo confocal microscopy (IVCM) findings in eyes with PLE. METHODS: This retrospective study included age-matched 7 (14 eyes) post-LASIK controls (PLCs) and 6 (12 eyes) PLE subjects. Corneal topography was used to categorise the subjects into PLC and PLE groups...
April 27, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28450379/posner-schlossman-syndrome-in-wenzhou-china-a-retrospective-review-study
#18
Jun Hong Jiang, Shao Dan Zhang, Ma Li Dai, Juan Yuan Yang, Yan Qian Xie, Cheng Hu, Guang Yun Mao, Fan Lu, Yuan Bo Liang
AIM: To describe the incidence of Posner-Schlossman syndrome (PSS) in Lucheng District, Wenzhou, China, over a 10-year period. METHODS: We reviewed retrospectively the medical records of all inpatient and outpatient patients diagnosed with PSS during the years 2005-2014 in the Eye Hospital of Wenzhou Medical University. The keywords of 'glaucomatocyclitic crisis', 'Posner-Schlossman syndrome' and 'PSS' were used for the retrieval. Only patients with registered residing address in Lucheng District where the hospital located were finally selected...
April 27, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28450378/long-term-outcomes-of-orbital-fat-decompression-in-graves-orbitopathy
#19
Anny M Cheng, Yi-Hsuan Wei, Sean Tighe, Hosam Sheha, Shu-Lang Liao
PURPOSE: To evaluate the long-term clinical efficacy of orbital fat decompression in treating proptosis in Graves' ophthalmopathy (GO). METHODS: Retrospective review of 1604 eyes of 845 patients with symmetric (1518 eyes) and asymmetric (86 eyes) proptosis who received orbital fat decompression between 2003 and 2014. Changes in Hertel values were evaluated at baseline, 6 months postoperatively and yearly thereafter. Recurrence of proptosis, diplopia and other complications that required additional surgeries were documented and analysed...
April 27, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28450377/fundus-findings-in-a-series-of-patients-with-extrapulmonary-tuberculosis-in-thailand
#20
Choeng Jirawison, Yingna Liu, Karjbundid Surasit, Ernest Maningding, Siripim Kamphaengkham, Somsanguan Ausayakhun, David Heiden, Todd P Margolis, John A Gonzales, Nisha R Acharya, Jeremy David Keenan
AIM: The aim of this study was to determine the frequency of fundus abnormalities among patients who are undergoing or have recently completed treatment for extrapulmonary tuberculosis (eTB). METHODS: This is a prospective cross-sectional study conducted in a TB clinic of a tertiary hospital in northern Thailand. All patients who had eTB between January 2014 and August 2015 were invited by telephone to return to the clinic for fundus photography. Three uveitis specialists reviewed all photographs to identify posterior segment lesions that were consistent with ocular TB...
April 27, 2017: British Journal of Ophthalmology
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