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British Journal of Ophthalmology

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https://www.readbyqxmd.com/read/28928267/impact-of-type-i-boston-keratoprosthesis-implantation-on-vision-related-quality-of-life
#1
Marcus Ang, Ryan Man, Eva Fenwick, Ecosse Lamoureux, Mark Wilkins
AIM: To determine the impact of type I Boston keratoprosthesis (KPro) implantation on vision-related quality of life (VRQoL). METHODS: Prospective study in 33 patients (mean age 56±12 years, 67% male) with bilateral corneal blindness, who underwent a KPro implantation at a single tertiary eye hospital (June 2011-July 2015). VRQoL was evaluated using the Impact of Vision Impairment Questionnaire (IVI) at baseline and at 3-6 months postsurgery, after stabilisation of best-corrected visual acuity (BCVA)...
September 19, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28928266/inter-relationship-between-visual-symptoms-activity-limitation-and-psychological-functioning-in-patients-with-diabetic-retinopathy
#2
Eva K Fenwick, Grand H-L Cheng, Ryan E K Man, Jyoti Khadka, Gwyn Rees, Tien Y Wong, Konrad Pesudovs, Ecosse Luc Lamoureux
AIMS: We explored the direct and indirect impact of restrictions in daily living activities on the relationship between perceived visual symptoms associated with diabetic retinopathy (DR) and psychological functioning. METHODS: In this prospective, cross-sectional study, 514 tertiary patients with DR (mean age±SD, 60.4±12.6 years; 64% male) answered questions related to nine domains of DR-specific quality of life. These were classified into the following predictor, mediating and outcome variables: visual symptoms (predictor variable); activity limitation, driving, lighting, social restriction, inconvenience, mobility (mediating variables); and emotional distress and concerns (outcome variables)...
September 19, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28928265/outcomes-of-lensectomy-and-risk-factors-for-failure-in-spherophakic-eyes-with-secondary-glaucoma
#3
Divya P Rao, Praveen J John, Mohammed Hasnat Ali, Ramesh Kekunnaya, Subhadra Jalali, Chandra Sekhar Garudadri, Sirisha Senthil
PURPOSE: To report the outcomes of lensectomy in spherophakic eyes with subluxated or dislocated crystalline lenses and secondary glaucoma. METHODS: Lensectomy was performed in 52 eyes, 36 eyes with lens subluxation and 16 eyes with lens dislocation with secondary glaucoma from 1991 to 2016. Glaucoma was diagnosed based on intraocular pressure (IOP) ≥22 mm Hg and/or glaucomatous optic disc damage. Complete success was defined as IOP ≥5 and ≤21 mm Hg without antiglaucoma medications (AGMs) or surgery, and eyes needing oral AGM or surgical intervention for IOP control or those with complication causing loss of light perception were considered failure...
September 19, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28928264/role-of-ultrasound-biomicroscopy-in-diagnosis-of-ocular-toxocariasis
#4
Qian Chen, Junxiang Gu, Rui Jiang, Min Zhou, Qing Chang
PURPOSE: To investigate ultrasound biomicroscopy (UBM) characteristics of patients with ocular toxocariasis (OT) and to explore the role of UBM in the diagnosis and differential diagnosis of OT. DESIGN: Cross-sectional study. METHODS: 78 eyes of 77 patients clinically consistent with OT and confirmed by serum and/or intraocular antibodies in a single tertiary centre (Fudan University Eye and ENT Hospital, Shanghai) between July 2009 and July 2016 were included in the study...
September 19, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28903967/long-term-follow-up-of-benign-positional-vertical-opsoclonus-in-infants-retrospective-cohort
#5
Amir Sternfeld, Daniella Lobel, Hana Leiba, Judith Luckman, Shalom Michowiz, Nitza Goldenberg-Cohen
BACKGROUND/AIMS: Benign positional vertical opsoclonus in infants, also described as paroxysmal tonic downgaze, is an unsettling phenomenon that leads to extensive work-up, although benign course has been reported in sporadic cases. We describe long-term follow-up of a series of infants with the phenomenon. METHODS: This retrospective cohort included all infants diagnosed with rapid downgaze eye movement in 2012-2015 and followed until 2016. The databases of two medical centres were retrospectively reviewed...
September 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28903966/laser-in-glaucoma-and-ocular-hypertension-light-trial-a-multicentre-randomised-controlled-trial-design-and-methodology
#6
Gus Gazzard, Evgenia Konstantakopoulou, David Garway-Heath, Keith Barton, Richard Wormald, Stephen Morris, Rachael Hunter, Gary Rubin, Marta Buszewicz, Gareth Ambler, Catey Bunce
PURPOSE: The Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial aims to establish whether initial treatment with selective laser trabeculoplasty (SLT) is superior to initial treatment with topical medication for primary open-angle glaucoma (POAG) or ocular hypertension (OHT). DESIGN: The LiGHT Trial is a prospective, unmasked, multicentre, pragmatic, randomised controlled trial. 718 previously untreated patients with POAG or OHT were recruited at six collaborating centres in the UK between 2012 and 2014...
September 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28903965/enteric-coated-mycophenolate-sodium-in-the-treatment-of-non-infectious-intermediate-uveitis-results-of-a-prospective-controlled-randomised-open-label-early-terminated-multicentre-trial
#7
Christoph M E Deuter, Katrin Engelmann, Arnd Heiligenhaus, Ines Lanzl, Friederike Mackensen, Thomas Ness, Uwe Pleyer, Nicole Stuebiger, Barbara Wilhelm, Holger Luedtke, Manfred Zierhut, Deshka Doycheva
BACKGROUND/AIMS: To evaluate the efficacy, safety and tolerability of enteric-coated mycophenolate sodium (EC-MPS) in combination with low-dose corticosteroids compared with a monotherapy with low-dose corticosteroids in subjects with non-infectious intermediate uveitis (IU). METHODS: Open-label, prospective, controlled, randomised multicentre trial. Patients were randomised in a 1:1 ratio to either the treatment group (prednisolone plus EC-MPS) or control group (prednisolone monotherapy)...
September 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28903964/clinical-profile-of-pythium-keratitis-perioperative-measures-to-reduce-risk-of-recurrence
#8
Shweta Agarwal, Geetha Iyer, Bhaskar Srinivasan, Mamta Agarwal, Shobha Panchalam Sampath Kumar, Lily K Therese
PURPOSE: To report the clinical profile and role of perioperative adjunctive measures to reduce the risk of recurrence in Pythium insidiosum keratitis. METHODS: Retrospective analysis of 10 eyes of 10 patients with P. insidiosum keratitis. Diagnosis was confirmed by PCR DNA sequencing. RESULTS: 7out of 10 patients were from urban locales, and none had any obvious history of injury with vegetative matter and were being treated for fungal keratitis...
September 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28903963/predictors-of-radio-induced-visual-impairment-after-radiosurgery-for-uveal-melanoma
#9
Carmen Rosaria Gigliotti, Giulio Modorati, Maura Di Nicola, Claudio Fiorino, Lucia Alessia Perna, Elisabetta Miserocchi, Alberto Franzin, Piero Picozzi, Angelo Bolognesi, Pietro Mortini, Antonella Del Vecchio, Riccardo Calandrino
AIMS: The aim of the present work is to assess the main predictors of the most clinically relevant radio-induced effects after Gamma Knife stereotactic radiosurgery (GKRS) for uveal melanoma (UM). MATERIALS AND METHODS: Medical records and three-dimensional dosimetry data of critical structures of 66 patients were retrospectively reviewed. Cox's proportional hazard model was used to identify clinical and dosimetric variables as independent risk factor for GKRS-related complications...
September 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28903962/an-evaluation-of-intracameral-mydriasis-for-routine-cataract-surgery
#10
Christopher B Schulz, Srini V Goverdhan, Roger C Humphry
BACKGROUND: Intracameral Mydrane might facilitate a more streamlined cataract service and improve the patient experience. There is limited 'real-world' evidence of its use in a UK setting. METHODS: As part of a local evaluation of cataract surgery using intracameral Mydrane (group 2; n=60), data were collected on intraoperative pupil size and postoperative visual acuity (VA), as well as the rate of mechanical pupil dilation, intraoperative floppy iris syndrome (IFIS) and complications...
September 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28903961/paediatric-optic-neuritis-factors-leading-to-unfavourable-outcome-and-relapses
#11
Delphine Averseng-Peaureaux, Marie Mizzi, Helene Colineaux, Laurence Mahieu, Maria Carmela Pera, David Brassat, Yves Chaix, Emilie Berard, Kumaran Deiva, Emmanuel Cheuret
OBJECTIVES: To identify prognostic factors associated with poor visual recovery and chronic relapsing diseases, for example, multiple sclerosis (MS), in children with optic neuritis (ON) at onset. METHODS: This multicentre retrospective study included 102 children with a first ON episode between 1990 and 2012. The primary criterion was poor visual recovery determined by visual acuity, and the secondary was relapses following ON. RESULTS: Median age was 11 years, 66% were girls and mean follow-up was 24 months...
September 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28893761/effectiveness-of-expanding-annual-mass-azithromycin-distribution-treatment-coverage-for-trachoma-in-niger-a-cluster-randomised-trial
#12
Abdou Amza, Boubacar Kadri, Beido Nassirou, Sun Y Cotter, Nicole E Stoller, Sheila K West, Robin L Bailey, Travis C Porco, Bruce D Gaynor, Jeremy D Keenan, Thomas M Lietman, Catherine E Oldenburg
BACKGROUND/AIMS: The WHO recommends 3-5 years of annual mass azithromycin distribution with at least 80% treatment coverage to districts with active trachoma prevalence over 10% among children. Here, we assess the efficacy of expanding the coverage target to at least 90% for trachoma control in a mesoendemic region of Niger. METHODS: Twenty-four communities were randomised to a single day of azithromycin distribution with a coverage target of 80% of the community or up to 4 days of treatment, aiming for greater than 90% coverage...
September 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28893760/characteristics-of-early-filtering-blebs-that-predict-successful-trabeculectomy-identified-via-three-dimensional-anterior-segment-optical-coherence-tomography
#13
Akiko Narita, Yuki Morizane, Tomoe Miyake, Jiro Seguchi, Tetsuya Baba, Fumio Shiraga
BACKGROUND/AIMS: To identify the cross-sectional characteristics of filtering blebs at 2 weeks post-trabeculectomy associated with intraocular pressure (IOP) control at 1 year post-trabeculectomy. METHODS: Ninety-nine eyes of 94 patients who had undergone primary trabeculectomy were included in this retrospective consecutive case series study. Surgical success was defined as an IOP ≤15 mm Hg and a >20% reduction in IOP without glaucoma medication or additional glaucoma surgeries at 1 year post-trabeculectomy...
September 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28860140/lens-power-in-iranian-schoolchildren-a-population-based-study
#14
Hassan Hashemi, Reza Pakzad, Rafael Iribarren, Mehdi Khabazkhoob, Mohammad Hassan Emamian, Akbar Fotouhi
AIMS: To evaluate lens power (LP) in schoolchildren aged 6-12 years. METHODS: This cross-sectional study was conducted in Shahroud, northeast Iran. The students were selected through random cluster sampling and underwent the measurements of biometry, uncorrected and corrected visual acuity, non-cycloplegic and cycloplegic refraction. The LP was calculated using the Bennett formula. RESULTS: Of 6624 invited children, 5620 (84.8%) participated in the study and data of 4870 children were finally analysed...
August 31, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28855198/diagnostic-accuracy-of-optical-coherence-tomography-for-diagnosing-glaucoma-secondary-analyses-of-the-gate-study
#15
Gianni Virgili, Manuele Michelessi, Jonathan Cook, Charles Boachie, Jennifer Burr, Katie Banister, David F Garway-Heath, Rupert R A Bourne, Almudena Asorey Garcia, Craig R Ramsay, Augusto Azuara-Blanco
BACKGROUND/AIMS: To assess the diagnostic performance of retinal nerve fibre layer (RNFL) data of optical coherence tomography (OCT) for detecting glaucoma. METHODS: Secondary analyses of a prospective, multicentre diagnostic study (Glaucoma Automated Tests Evaluation (GATE)) referred to hospital eye services in the UK were conducted. We included data from 899 of 966 participants referred to hospital eye services with suspected glaucoma or ocular hypertension. We used both eyes' data and logistic regression-based receiver operator characteristics analysis to build a set of models to measure the sensitivity and specificity of the average and inferior quadrant RNFL thickness data of OCT...
August 30, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28855197/optical-coherence-tomography-angiography-reproducibility-of-lesion-size-measurements-in-neovascular-age-related-macular-degeneration-amd
#16
Francesca Amoroso, Alexandra Miere, Oudy Semoun, Camille Jung, Vittorio Capuano, Eric H Souied
PURPOSE: To evaluate the reproducibility and interuser agreement of measurements of choroidal neovascularisation in optical coherence tomography angiography (OCTA). DESIGN: Prospective non-interventional study. METHODS: Consecutive patients, presenting with neovascular age-related macular degeneration (AMD), underwent two sequential OCTA examinations (AngioVue, Optovue, Fremont, California, USA), performed by the same trained examiner. Neovascular lesion area was then measured on both examinations in the choriocapillaris automatic segmentation by two masked readers, using the semiautomated measuring software embedded in the instrument...
August 30, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28855196/a-worldwide-survey-of-retinopathy-of-prematurity-screening
#17
Justin S Mora, Christopher Waite, Clare E Gilbert, Brenda Breidenstein, John J Sloper
BACKGROUND: To ascertain which countries in the world have retinopathy of prematurity (ROP) screening programmes and guidelines and how these were developed. METHODS: An email database was created and requests were sent to ophthalmologists in 141 nations to complete an online survey on ROP screening in their country. RESULTS: Representatives from 92/141 (65%) countries responded. 78/92 (85%) have existing ROP screening programmes, and 68/78 (88%) have defined screening criteria...
August 30, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28855195/prevalence-and-risk-factors-for-diabetic-retinopathy-in-china-a-multi-hospital-based-cross-sectional-study
#18
Guihua Zhang, Haoyu Chen, Weiqi Chen, Mingzhi Zhang
PURPOSE: To determine the prevalence and risk factors for diabetic retinopathy (DR) and sight-threatening diabetic retinopathy (STDR) in a multi-hospital-based DR screening programme among patients with diabetes in China, the Lifeline Express Diabetic Retinopathy Screening Program. METHODS: Patients with diabetes in eight hospitals across mainland China (both southern and northern) from January 2014 to July 2016 were recruited in this programme. All participants underwent a standardised interview and examinations and received digital fundus photography...
August 30, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28855194/keratopigmentation-with-micronised-mineral-pigments-complications-and-outcomes-in-a-series-of-234-eyes
#19
Jorge L Alio, Olena Al-Shymali, Maria A Amesty, Alejandra E Rodriguez
AIM: To report the complications observed in a consecutive large series of cases treated with keratopigmentation (KTP). METHODS: KTP was performed in 234 eyes of 204 patients for therapeutic and cosmetic reasons. From them, 50 eyes of 29 patients suffered complications. Different KTP techniques and three generations of pigments (GP) were used. The follow-up period ranged from 4 months to 12 years. Light sensitivity (LS), visual field (VF) limitations and MRI alterations were considered functional complications...
August 30, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28855193/risk-of-corneal-ulcer-in-patients-with-end-stage-renal-disease-a-retrospective-large-scale-cohort-study
#20
Ren-Long Jan, Ming-Cheng Tai, Shih-Feng Weng, Chun Chang, Jhi-Joung Wang, Yuh-Shin Chang
BACKGROUND/AIMS: To investigate the risk of corneal ulcer in patients with end-stage renal disease (ESRD). METHODS: This retrospective, nationwide, matched cohort study included 92 967 patients with ESRD recruited between 2000 and 2009 from the Taiwan National Health Insurance Research Database. The same number of age-matched and sex-matched patients without ESRD were selected from the Taiwan Longitudinal Health Insurance Database, 2000 as the control group. Data for each patient were collected from the index date until December 2011...
August 30, 2017: British Journal of Ophthalmology
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