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British Journal of Ophthalmology

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https://www.readbyqxmd.com/read/28077370/preoperative-aqueous-humour-flare-values-do-not-predict-proliferative-vitreoretinopathy-in-patients-with-rhegmatogenous-retinal-detachment
#1
Verena C Mulder, Jan Tode, Elon Hc van Dijk, Konstantine Purtskhvanidze, Johann Roider, Jan C van Meurs, Felix Treumer
BACKGROUND/AIMS: Patients with rhegmatogenous retinal detachment (RRD) who develop postoperative proliferative vitreoretinopathy (PVR) have been found to have higher preoperative laser flare values than patients with RRD who do not develop this complication. Measurement of laser flare has therefore been proposed as an objective, rapid and non-invasive method for identifying high-risk patients. The purpose of our study was to validate the use of preoperative flare values as a predictor of PVR risk in two additional patient cohorts, and to confirm the sensitivity and specificity of this method for identifying high-risk patients...
January 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28077369/the-relationship-between-central-visual-field-sensitivity-and-macular-ganglion-cell-inner-plexiform-layer-thickness-in-glaucoma
#2
Ji-Woong Lee, Esteban Morales, Farideh Sharifipour, Navid Amini, Fei Yu, Abdelmonem A Afifi, Anne L Coleman, Joseph Caprioli, Kouros Nouri-Mahdavi
AIMS: To explore the correlation of local macular ganglion cell/inner plexiform layer (GC/IPL) thickness measurements with sensitivity at individual test locations on the central 10-2 visual fields (VFs) in patients with glaucoma. METHODS: One hundred thirty-seven eyes of 125 patients with spectral domain optical coherence tomography (OCT) and 10-2 VFs were included. The exported thickness matrices (200×200) of GC/IPL measurements were centred on the fovea. Total deviation values at each test location were correlated with the 20 000 GC/IPL thickness measurements in the corresponding inferior or superior hemiretina, and areas of highest correlation were plotted...
January 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057649/choroid-morphometric-analysis-in-non-neovascular-age-related-macular-degeneration-by-means-of-optical-coherence-tomography-angiography
#3
Maria Vittoria Cicinelli, Alessandro Rabiolo, Alessandro Marchese, Luigi de Vitis, Adriano Carnevali, Lea Querques, Francesco Bandello, Giuseppe Querques
AIMS: To describe the vascular changes in patients affected by non-neovascular age-related macular degeneration (AMD), featuring reticular pseudodrusen (RPD), drusen, or both RPD and drusen by means of optical coherence tomography angiography (OCT-A). METHODS: Cross-sectional observational case series. Patients with non-neovascular AMD presenting at the Medical Retina Service of the Department of Ophthalmology, University Vita-Salute San Raffaele in Milan were recruited...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057648/in-vitro-experiment-to-elucidate-the-mechanism-of-the-soft-shell-technique-for-preventing-subretinal-migration-of-perfluoro-octane
#4
Yau Kei Chan, Yongjie Lu, Gabriela Czanner, Jing Wu, Ho Ching Cheng, Rumana Hussain, Taiji Sakamoto, Ho Cheung Shum, David Wong
AIM: Perfluorocarbon liquid (PFCL) can migrate into subretinal space in detached and stiffened retina with open holes during vitreoretinal surgery. An innovative 'soft shell' technique was introduced to reduce the complication using hyaluronate (HA) to 'cover' the retinal hole. This study aims to study the effectiveness of this technique in vitro. METHODS: Ex vivo porcine retina was mounted on a transwell insert. Beneath the retina was an aqueous solution. Two retinal holes were made using needle punctures...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057647/characterisation-of-choroidal-morphological-and-vascular-features-in-diabetes-and-diabetic-retinopathy
#5
Preeti Gupta, Sri Gowtham Thakku, Charumathi Sabanayagam, Gavin Tan, Chui Ming Gemmy Cheung, Ecosse L Lamoureux, Tien-Yin Wong, Ching-Yu Cheng
AIM: We aimed to characterise specific morphological and vascular features of the choroid in Indian adults with diabetes and diabetic retinopathy (DR). METHODS: Consecutive participants from the Singapore Indian Eye Study's 6-year follow-up examination underwent choroidal imaging using spectral domain optical coherence tomography (OCT) with enhanced depth imaging. Raw OCT images were loaded on a custom-written application on MATLAB that enabled delineation for detailed morphological and vascular analyses...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057646/incidence-mechanism-and-outcomes-of-schisis-retinal-detachments-revealed-through-a-prospective-population-based-study
#6
Kanmin Xue, Mahiul M K Muqit, Eric Ezra, Stephen J Charles, David Yorston, Arijit Mitra, Chetan K Patel
AIM: To determine the incidence, presentation and outcomes of progressive sight-threatening retinal detachment (RD) complicating degenerative retinoschisis. METHODS: We conducted the first prospective population-based epidemiological study of progressive schisis detachment over a 1-year period (2014-2015) in the UK. Case ascertainment was via monthly British Ophthalmological Surveillance Unit reporting cards sent to all ophthalmologists in the UK. For each reported case, data were collected using incident and 6 months follow-up questionnaires gathering information including demographic, presenting symptoms, retinal findings, primary management, primary outcome, secondary management and secondary outcome...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057645/optical-coherence-tomography-angiography-in-acute-non-arteritic-anterior-ischaemic-optic-neuropathy
#7
Sourabh Sharma, Marcus Ang, Raymond P Najjar, Chelvin Sng, Carol Y Cheung, Annadata V Rukmini, Leopold Schmetterer, Dan Milea
PURPOSE: To characterise vascular changes in eyes with acute non-arteritic anterior ischaemic optic neuropathy (NAION), using optical coherence tomography angiography (OCT-A) imaging. METHODS: This hospital-based observational case-control study included included five patients with acute NAION (6 eyes), within 7 days after onset of symptoms and 19 age-matched healthy controls (19 eyes). OCT-A (RTVue XR 100; Optovue, Fremont, California, USA), covering a 4.5×4...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057644/efficacy-of-topical-cysteamine-in-nephropathic-cystinosis
#8
Amal Al-Hemidan, Samir S Shoughy, Igor Kozak, Khalid F Tabbara
PURPOSE: The aim of this study is to evaluate the efficacy of topical cysteamine 0.55% eye drops in the treatment of corneal cystine crystal deposits in patients with nephropathic cystinosis. METHODS: Thirty-two patients with nephropathic cystinosis were prospectively included in the study. Patients with corneal cystinosis were treated with topical cysteamine 0.55% eye drops. They were examined before treatment, on each monthly visit and after treatment at the last follow-up...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057643/retinal-segmented-layers-with-strong-aquaporin-4-expression-suffered-more-injuries-in-neuromyelitis-optica-spectrum-disorders-compared-with-optic-neuritis-with-aquaporin-4-antibody-seronegativity-detected-by-optical-coherence-tomography
#9
Chun Xia Peng, Hong Yang Li, Wei Wang, Jun Qing Wang, Lei Wang, Quan Gang Xu, Shan Shan Cao, Huan Fen Zhou, Shuo Zhao, Shi Hui Wei
PURPOSE: To evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO) with ON eyes (NMO-ON) compared with an AQP4-Ab seronegative ON (AQP4-Ab-/ON) cohort using optical coherence tomography (OCT). METHODS: We recruited 109 patients with ON (161 eyes) and 47 healthy controls. All patients with ON were subdivided into three subcohorts: 37 patients (54 eyes) with AQP4-Ab+/ON, 45 patients (65 eyes) with AQP4-Ab-/ON and 27 patients (42 eyes) with NMO-ON...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057642/accelerated-transepithelial-corneal-cross-linking-for-progressive-keratoconus-a-prospective-study-of-12%C3%A2-months
#10
Wei Aixinjueluo, Tomohiko Usui, Takashi Miyai, Tetsuya Toyono, Toshihiro Sakisaka, Satoru Yamagami
BACKGROUND/AIMS: To evaluate the clinical results of accelerated transepithelial corneal cross-linking (CXL) in Japanese patients with progressive keratoconus (KCN). METHODS: Thirty eyes of 19 patients (16 male, 3 female patients) with progressive KCN were included. The mean age was 24.9±7.0 (range 16-38) years. All patients received ultraviolet A radiation for 3 min at an irradiance of 30 mW/cm(2). Patients were followed up on the first day, at 1 week and 2 weeks, and at 1 month, 3 months, 6 months and 12 months postoperatively...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28043985/in-vivo-confocal-microscopy-appearance-of-fusarium-and-aspergillus-species-in-fungal-keratitis
#11
Jaya Devi Chidambaram, Namperumalsamy Venkatesh Prajna, Natasha Larke, David Macleod, Palepu Srikanthi, Shruti Lanjewar, Manisha Shah, Prajna Lalitha, Shanmugam Elakkiya, Matthew J Burton
BACKGROUND: Clinical outcomes in fungal keratitis vary between Fusarium and Aspergillus spp, therefore distinguishing between species using morphological features such as filament branching angles, sporulation along filaments (adventitious sporulation) or dichotomous branching may be useful. In this study, we assessed these three features within Heidelberg Retina Tomograph 3 in vivo confocal microscopy (IVCM) images from culture-positive Fusarium and Aspergillus spp keratitis participants...
January 2, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28043984/cataract-surgery-in-uveitis-a-multicentre-database-study
#12
Colin J Chu, Andrew D Dick, Robert L Johnston, Yit C Yang, Alastair K Denniston
BACKGROUND/AIMS: Cataract is an important source of visual loss in patients with uveitis. Whether or not outcomes of cataract surgery in eyes with uveitis are worse compared with non-uveitic eyes have to date been compromised by lack of reliable estimates of benefit and harm, which require data from large cohorts. METHODS: Electronic medical record data were extracted from eight independent UK clinical sites for eyes undergoing cataract extraction between January 2010 and December 2014...
January 2, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28003235/patients-perception-of-ded-and-its-relation-with-time-to-diagnosis-and-quality-of-life-an-international-and-multilingual-survey
#13
Marc Labetoulle, Maurizio Rolando, Christophe Baudouin, Gysbert van Setten
BACKGROUND/AIMS: To improve understanding of patients' experience and perception of dry eye disease (DED) and its impact on quality of life (QoL). METHODS: This survey was observational, non-interventional and cross-sectional. The survey was conducted online on 706 patients with DED from five European countries (France, Germany, Italy, Spain and the UK). All patients met the following inclusion criteria: 40 years or older with DED diagnosed by a healthcare professional (HCP), not wearing contact lenses and using tear substitutes daily for at least 6 months...
December 21, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27974291/organ-cultured-prestripped-donor-tissue-for-dmek-surgery-clinical-outcomes
#14
Johannes Menzel-Severing, Friedrich E Kruse, Theofilos Tourtas
AIM: To determine whether clinical performance is negatively affected by prestripping Descemet membrane endothelial keratoplasty (DMEK) grafts from organ-cultured corneas. METHODS: We reviewed clinical records of all patients who underwent DMEK surgery for Fuchs endothelial dystrophy between 28 October 2014 and 11 August 2015. Grafts had been prepared from organ-cultured corneoscleral buttons 24 hours prior to surgery or during surgery. We included only patients for which at least one follow-up examination was available at a minimum of 2 months postoperatively...
December 14, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27965261/very-early-endothelial-cell-loss-after-penetrating-keratoplasty-with-organ-cultured-corneas
#15
Anne Sophie Gauthier, Thibaud Garcin, Gilles Thuret, Zhiguo He, Remy Jullienne, Marie Caroline Trone, Chaker Nefzaoui, Sophie Acquart, Fabien Forest, Michel Péoc'h, Bernard Delbosc, Philippe Gain
AIMS: After keratoplasty, postoperative endothelial cell loss is calculated between the eye bank endothelial cell density (ebECD) and the postoperative specular microscopy (SM). To elucidate the very early cell loss, always described after penetrating keratoplasty (PK), we designed two complementary studies. METHODS: (1) Clinical prospective study of 90 consecutive PKs (keratoconus, Fuchs' corneal dystrophy, lattice dystrophy, bullous keratopathy) with organ-cultured corneas and postoperative follow-up by SM at day 5 (D5), D15, month 1 (M1) and M3...
December 13, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27941050/effects-of-ocular-and-systemic-factors-on-the-progression-of-glaucomatous-visual-field-damage-in-various-sectors
#16
Ryo Asaoka, Hiroshi Murata, Yuri Fujino, Kazunori Hirasawa, Masaki Tanito, Shiro Mizoue, Kazuhiko Mori, Katsuyoshi Suzuki, Takehiro Yamashita, Kenji Kashiwagi, Atsuya Miki, Nobuyuki Shoji
BACKGROUND/AIM: To investigate the effects of ocular and systemic risk factors for glaucomatous progression in different sectors of the visual field (VF). METHOD: 409 eyes from 268 patients with 10 reliable VFs from the Japanese Archive of Multicentral Databases in Glaucoma (JAMDIG) were investigated. VFs were divided into six sectors (mean total deviation (mTD)s20+, mTDs10-20 and mTDs0-10, >20°, 10-20° and <10° in the superior hemifield, respectively; and mTDi20+, mTDi10-20 and mTDi0-10, >20°, 10-20° and <10° in the inferior hemifield, respectively)...
December 9, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27941049/understanding-the-reasons-for-loss-to-follow-up-in-patients-with-glaucoma-at-a-tertiary-referral-teaching-hospital-in-korea
#17
Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
BACKGROUND/AIMS: To assess the reasons and factors for discontinuation of follow-up among patients with glaucoma at a tertiary referral teaching hospital in Seoul, Korea. METHODS: We identified all adult patients with glaucoma (≥18 years), who had visited the glaucoma clinic of Seoul National University Hospital between April 2012 and March 2014 and had missed an appointment by at least 12 months. These patients were traced via cellular phone, and their true status and reasons for discontinuation of follow-up were documented...
December 9, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27941048/the-association-between-skin-autofluorescence-and-mean-deviation-in-patients-with-open-angle-glaucoma
#18
Noriko Himori, Hiroshi Kunikata, Ryo Kawasaki, Yukihiro Shiga, Kazuko Omodaka, Hidetoshi Takahashi, Toshio Miyata, Toru Nakazawa
BACKGROUND: It has been suggested that local and systemic oxidative stress levels are causal risk factors for glaucoma. AIM: To evaluate the effect of age on the role of systemic oxidative stress in open-angle glaucoma (OAG). METHODS: This study included 502 eyes of 251 Japanese patients with OAG. Systemic oxidative stress was assessed with skin autofluorescence (SAF), an indicator of advanced glycogen end products. We selected the youngest and oldest patients by quartile (≤58 and ≥74 years old, respectively) and determined the univariate correlation between SAF and mean deviation (MD) of the visual field in both eyes of each group...
December 9, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27941047/cataract-surgery-in-children-with-retinopathy-of-prematurity-rop-surgical-outcomes
#19
Chinyelu Nkemdilim Ezisi, Ramesh Kekunnaya, Subhadra Jalali, Divya Balakrishnan, Padmaja Kumari Rani, Ashik Mohamed, Preeti Patil Chhablani
PURPOSE: To report the outcomes of cataract surgery in children with retinopathy of prematurity (ROP). METHODS: A retrospective case review of all children diagnosed with ROP from January 2001 to December 2014 was done and those who underwent cataract surgery were included in the study. Details of ROP and cataract treatment, postoperative complications and outcomes were analysed. RESULTS: Of the 2258 children diagnosed to have ROP, 28 eyes of 22 children were included, 14 boys and 8 girls...
December 9, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27941046/topical-1-5-fluoruracil-as-a-sole-treatment-of-corneoconjunctival-ocular-surface-squamous-neoplasia-long-term-study
#20
Raffaele Parrozzani, Luisa Frizziero, Sara Trainiti, Ilaria Testi, Giacomo Miglionico, Elisabetta Pilotto, Stella Blandamura, Ambrogio Fassina, Edoardo Midena
AIMS: To report long-term clinical outcome of topical 1% 5-fluoruracil (5-FU) as a sole treatment of ocular surface squamous neoplasia (OSSN). METHODS: 41 patients affected by OSSN were included. Each patient underwent full ophthalmological examination at baseline, with cytological or histological confirmation. Patients were treated by topical chemotherapy with 1% 5-FU four times a day for 4 weeks. One course was defined as 4 weeks of topical chemotherapy. Adjunctive courses were administered after 1 month of chemotherapy-free interval...
December 9, 2016: British Journal of Ophthalmology
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