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Bone Marrow Transplantation

journal
https://www.readbyqxmd.com/read/29743574/peripheral-hematopoietic-stem-cell-mobilization-utilizing-growth-factors-in-donors-with-sickle-cell-trait-is-safe-and-effective
#1
LETTER
Moussab Damlaj, Ahmed Alaskar, Samer Ghazi, Bader Alahmari, Ayman Alhejazi, Mohsen Al-Zahrani
No abstract text is available yet for this article.
May 9, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29743573/foxp3-expression-in-induced-t-regulatory-cells-derived-from-human-umbilical-cord-blood-vs-adult-peripheral-blood
#2
Jeong-Su Do, Fei Zhong, Alex Y Huang, Wouter J Van't Hof, Marcie Finney, Mary J Laughlin
Foxp3 is essential for T regulatory cell (Treg) function. Broad complex-Tramtrack-Bric-a-brac domain (BTB) and Cap'n'collar (CNC) homology 1, transcription factor 2 (BACH2) stabilizes Treg immune homeostasis in murine studies. However, little is known regarding what role, if any, BACH2 may have in Foxp3 regulation in human-induced Treg (iTreg). We examined Foxp3 expression and regulation comparing iTreg differentiated from umbilical cord blood (UCB) vs. adult blood (AB) naive CD4+ T-cells. Foxp3 expression was higher in UCB vs...
May 9, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29740182/overcoming-human-disagreement-assessing-erythematous-lesion-severity-on-3d-photos-of-chronic-graft-versus-host-disease
#3
LETTER
Eric R Tkaczyk, Fuyao Chen, Jianing Wang, Jocelyn S Gandelman, Inga Saknite, Laura E Dellalana, Madan H Jagasia, Benoit M Dawant
No abstract text is available yet for this article.
May 8, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29740181/adoptive-transfer-of-cellular-immunity-against-cytomegalovirus-by-virus-specific-lymphocytes-from-a-third-party-family-donor
#4
LETTER
Monika Lindemann, Britta Eiz-Vesper, Nina K Steckel, Sabine Tischer, Melanie Fiedler, Andreas Heinold, Vesna Klisanin, Britta Maecker-Kolhoff, Rainer Blasczyk, Peter A Horn, Dietrich W Beelen, Michael Koldehoff
No abstract text is available yet for this article.
May 8, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29740180/high-dose-chemotherapy-and-autotransplants-for-plasma-cell-myeloma-in-jordan
#5
LETTER
Khalid Halahleh, Mohammad Ma'koseh, Husam Abu-Jazar, Sameer Yaser, Hani Howar, Mohamad Al-Rawashdeh, Abdelghani Tbakhi, Rula Najjar, Nilly Hussein, Dalia Al-Rimawi, Robert Peter Gale, Mahmoud Sarhan
No abstract text is available yet for this article.
May 8, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29740179/iodine-staining-and-p16-immunohistochemistry-as-a-novel-screening-for-secondary-esophageal-neoplasm-after-hematopoietic-stem-cell-transplantation
#6
LETTER
Takahiko Sato, Aika Seto, Yusuke Kagaya, Naomi Kawashima, Daisuke Koyama, Takanobu Morishita, Yukiyasu Ozawa, Koichi Miyamura, Takeo Yamaguchi, Jun-Ichi Haruta, Masafumi Ito
No abstract text is available yet for this article.
May 8, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29740178/trends-and-outcomes-first-100-bone-marrow-transplants-at-a-tertiary-care-center-in-islamabad-pakistan
#7
LETTER
Fahad Mushtaq, Umer Farooq, Kamran Rashid, Ayesha Junaid, Tahir Aziz, Yasir Iqbal, Shawana Kamran, Danish Khan, Waseem Sajjad, M Ayaz Mir
No abstract text is available yet for this article.
May 8, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29740177/longitudinal-follow-up-of-response-status-and-concomitant-immunosuppression-in-patients-treated-with-extracorporeal-photopheresis-for-chronic-graft-versus-host-disease
#8
Marietta Nygaard, Tonny Karlsmark, Niels Smedegaard Andersen, Ida Marie Schjødt, Søren Lykke Petersen, Lone Smidstrup Friis, Brian Thomas Kornblit, Henrik Sengeløv
Improvement in chronic graft vs. host disease (cGvHD) following treatment with extracorporeal photopheresis (ECP) has been shown previously. However, the effect is often measured at only one point in time or as best response. Chronic GvHD activity fluctuates over time, so we retrospectively evaluated cGvHD responses in 54 patients with primarily moderate or severe cGvHD throughout the ECP treatment course and after stopping ECP. The dominant response was partial remission (PR) in 33 patients, no change (NC) in 10 patients, progressive disease (PD) in 10 patients and complete remission (CR) in one patient...
May 8, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29728701/ibrutinib-for-bridging-to-allogeneic-hematopoietic-cell-transplantation-in-patients-with-chronic-lymphocytic-leukemia-or-mantle-cell-lymphoma-a-study-by-the-ebmt-chronic-malignancies-and-lymphoma-working-parties
#9
Peter Dreger, Mauricette Michallet, Paul Bosman, Sascha Dietrich, Mohamad Sobh, Ariane Boumendil, Arnon Nagler, Christof Scheid, Jan Cornelissen, Dietger Niederwieser, Lutz Müller, Elizabeth Vandenberghe, Ilaria Scortechini, Helene Schoemans, Niels S Andersen, Jürgen Finke, Domenico Russo, Per Ljungman, Jakob Passweg, Michel van Gelder, Nadira Durakovic, Helene Labussiere-Wallet, Tobias Berg, Gerald Wulf, Wolfgang Bethge, Donald Bunjes, Stefan Stilgenbauer, Maria Elisa Canepari, Michel Schaap, Christopher P Fox, Nicolaus Kröger, Silvia Montoto, Johannes Schetelig
The aim of this retrospective study was to investigate the safety and efficacy of allogeneic hematopoietic cell transplantation (alloHCT) in patients pre-treated with ibrutinib. Eligible were patients aged >18 years allotransplanted for chronic lymphocytic leukemia (CLL) or mantle cell lymphoma (MCL) after prior exposure to ibrutinib who were registered with the EBMT registry. Seventy patients (CLL 48, MCL 22) were included. At the time of alloHCT, 73% of the patients were ibrutinib responsive. All patients except one engrafted, and acute GVHD grade 2-4 (3-4) was observed in 49% (12%) of 68 evaluable patients...
May 4, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29728700/combination-therapy-with-carfilzomib-lenalidomide-and-dexamethasone-krd-results-in-an-unprecedented-purity-of-the-stem-cell-graft-in-newly-diagnosed-patients-with-myeloma
#10
Nishant Tageja, Neha Korde, Dickran Kazandjian, Sandhya Panch, Elisabet Manasanch, Manisha Bhutani, Mary Kwok, Sham Mailankody, Constance Yuan, Maryalice Stetler-Stevenson, Susan F Leitman, Claude Sportes, Ola Landgren
Still, many physicians give 4 cycles of combination therapy to multiple myeloma patients prior to collection of stem cells for autologous bone marrow transplant. This tradition originates from older doxorubicin-containing regiments which limited the number of cycles due to cumulative cardiotoxicity. Using older regiments, most patients had residual myeloma cells in their autologous stem-cell grafts during collection. Emerging data show that newly diagnosed multiple myeloma patients treated with modern carfilzomib/lenalidomide/dexamethasone (KRd) therapy, on average, take 6 cycles until reaching minimal residual disease (MRD) negativity...
May 4, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29728699/circulating-monocyte-subsets-in-human-chronic-graft-versus-host-disease
#11
Takaaki Konuma, Chisato Kohara, Eri Watanabe, Motoko Mizukami, Etsuko Nagai, Maki Oiwa-Monna, Susumu Tanoue, Masamichi Isobe, Koji Jimbo, Seiko Kato, Satoshi Takahashi, Arinobu Tojo
Chronic graft-versus-host disease (cGVHD) is a major cause of late morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Monocytes/macrophages play a central role in inflammation, tissue repair, and fibrosis, which are the main clinical features of cGVHD. Here, we examined the expression levels of activation markers, chemokine receptors, and scavenger receptors for each circulating monocyte subset in 145 patients without disease recurrence at least 12 months after undergoing allogeneic HCT...
May 4, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29728698/impact-of-high-dose-steroid-premedication-on-the-outcome-of-myeloablative-t-cell-replete-haploidentical-peripheral-blood-stem-cell-transplant
#12
LETTER
Ayman Saad, Alankrita Taneja, Antonio Di Stasi, Rehan Sarmad, Rivvi Kukkamalla, Luciano Costa, Donna Salzman, Racquel Innis-Shelton, Joseph H Chewning, Ruby F Meredith, Vera Hauptfeld, Samantha Langford, KirbyAnn Plessala, Ravi Bhatia, Lawrence S Lamb, Shin Mineishi
No abstract text is available yet for this article.
May 4, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29728697/hematopoietic-stem-cell-transplantation-for-adult-sickle-cell-disease-in-the-era-of-universal-donor-availibility
#13
Hafiz Muhammad Aslam, Said Yousuf, Adetola Kassim, Shumaila Muhammad Iqbal, Shahrukh K Hashmi
Current projections estimate that the number of newborns with sickle cell disease (SCD) globally will exceed 400,000 by 2050. Over the last three decades, increased newborn screening, supportive care, and use of hydroxyurea therapy, have decreased early childhood mortality among individuals affected with SCD. Despite hematopoietic cell transplantation (HCT) being curative in SCD, its impact on disease free survival remains unknown, especially in adults, partly due to previous limitations in donor options and perceived mortality in adults using myeloablative conditioning...
May 4, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29728696/introducing-prof-shaun-mccann-bone-marrow-transplantation-s-new-sommelier
#14
EDITORIAL
Robert Peter Gale
No abstract text is available yet for this article.
May 4, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29725110/how-to-define-and-measure-thymopoiesis-after-transplantation
#15
LETTER
Coco de Koning, Stefan Nierkens, Jaap Jan Boelens
No abstract text is available yet for this article.
May 3, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29725109/busulfan-fludarabine-and-cyclophosphamide-bfc-conditioning-allowed-stable-engraftment-after-haplo-identical-allogeneic-stem-cell-transplantation-in-children-with-adrenoleukodystrophy-and-mucopolysaccharidosis
#16
LETTER
Yao Chen, Lan-Ping Xu, Xiao-Hui Zhang, Huan Chen, Feng-Rong Wang, Kai-Yan Liu, Jiong Qin, Yan-Ling Yang, Xiao-Jun Huang
No abstract text is available yet for this article.
May 3, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29720705/recommendations-from-the-european-society-for-blood-and-marrow-transplantation-ebmt-for-a-curriculum-in-hematopoietic-cell-transplantation
#17
Mohamad Mohty, Rafael F Duarte, Jurgen Kuball, Peter Bader, Grzegorz W Basak, Chiara Bonini, Enric Carreras, Christian Chabannon, Carlo Dufour, Andrew Gennery, Arjan Lankester, Francesco Lanza, Per Ljungman, Silvia Montoto, Arnon Nagler, John A Snowden, Jan Styczynski, Anna Sureda, Nicolaus Kröger
Hematopoietic cell transplantation (HCT) is increasingly used worldwide. This treatment approach is complex and requires specific knowledge and training. The European Society for Blood and Marrow Transplantation (EBMT) identified the need for a set of international recommendations for the clinical training of physicians to qualify them as being competent in performing HCT procedures as well as novel cellular immune therapies and taking care of such patients. The goal is to implement an EBMT HCT-focused global curriculum (EBMT-GC) that can serve as a tool for the development of the HCT sub-specialty worldwide...
May 2, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29720704/diagnostic-value-of-highly-sensitive-chimerism-analysis-after-allogeneic-stem-cell-transplantation
#18
Lea Sellmann, Kim Rabe, Ivonne Bünting, Elke Dammann, Gudrun Göhring, Arnold Ganser, Michael Stadler, Eva M Weissinger, Lothar Hambach
Conventional analysis of host chimerism (HC) frequently fails to detect relapse before its clinical manifestation in patients with hematological malignancies after allogeneic stem cell transplantation (allo-SCT). Quantitative PCR (qPCR)-based highly-sensitive chimerism analysis extends the detection limit of conventional (short tandem repeats-based) chimerism analysis from 1 to 0.01% host cells in whole blood. To date, the diagnostic value of highly-sensitive chimerism analysis is hardly defined. Here, we applied qPCR-based chimerism analysis to 901 blood samples of 71 out-patients with hematological malignancies after allo-SCT...
May 2, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29712994/allogeneic-hematopoietic-stem-cell-transplantation-should-be-in-preference-to-conventional-chemotherapy-as-post-remission-treatment-for-adults-with-lymphoblastic-lymphoma
#19
LETTER
Luxin Yang, Yamin Tan, Jimin Shi, Yanmin Zhao, Yuanyuan Zhu, Yongxian Hu, Wenjue Pan, Yishan Ye, Jingsong He, Weiyan Zheng, Jie Sun, Zhen Cai, He Huang, Yi Luo
No abstract text is available yet for this article.
April 30, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29712993/development-of-a-quantitative-pcr-detecting-cunninghamella-bertholletiae-to-help-in-diagnosing-this-rare-and-aggressive-mucormycosis
#20
Anne-Pauline Bellanger, Ana Berceanu, Steffi Rocchi, Benoit Valot, Jean Fontan, Adrien Chauchet, Nicolas Belin, Emeline Scherer, Eric Deconinck, Jean-Christophe Navellou, Laurence Millon
Mucormycosis is an invasive mold infection, frequently fatal in immunocompromised patients. We report the case of a patient with chronic lymphocytic leukemia admitted to the hematology unit for febrile aplasia. Pulmonary lesions suggesting a fungal infection expanded/increased despite a combination of posaconazole and liposomal amphotericin B. The fungal biomarkers performed repeatedly were negative. At D65 after chemotherapy a bronchial biopsy was positive for Cunninghamella bertholletiae. The patient died despite appropriate antifungal management...
April 30, 2018: Bone Marrow Transplantation
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