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Bone Marrow Transplantation

journal
https://www.readbyqxmd.com/read/28504666/conditioning-regimens-for-allogeneic-hematopoietic-stem-cell-transplants-in-acute-myeloid-leukemia
#1
REVIEW
Y S Jethava, S Sica, B Savani, F Socola, M Jagasia, M Mohty, A Nagler, A Bacigalupo
AML is currently the first indication for allogeneic hematopoietic stem cell transplantation (allo-HSCT), as shown by international transplant registries. The conditioning regimens are classified as myeloablative conditioning, non-myeloablative or reduced intensity conditioning. Targeted radioimmunotherapy such as anti-CD45 antibody have also been added to the conditioning regimen in an attempt to improve tumor cell kill. Refinement of standard regimens has led to a reduction of non-relapse mortality, also in the older age group over 60 or 70 years of age...
May 15, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28504665/upper-gi-gvhd-similar-outcomes-to-other-grade-ii-graft-versus-host-disease
#2
R S Mehta, Q Cao, S Holtan, M L MacMillan, D J Weisdorf
The significance of upper gastrointestinal tract (UGI) acute GVHD (aGVHD) compared with other grade II aGVHD is not clearly defined. We compared the outcomes of patients with grade II aGVHD with or without biopsy-proven UGI involvement in three groups: grade II aGVHD without UGI (n=178), grade II aGVHD with UGI and other sites (n=102) and isolated UGI aGVHD (n=32). The overall response (ORR) to steroids at day 28 differed among the three groups (76, 67 and 91%, respectively, P=0.01), but was only marginally different in direct comparison with those without or with UGI aGVHD (P=0...
May 15, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28504664/pre-transplant-ferritin-albumin-and-haemoglobin-are-predictive-of-survival-outcome-independent-of-disease-risk-index-following-allogeneic-stem-cell-transplantation
#3
L Chee, M Tacey, B Lim, A Lim, J Szer, D Ritchie
Prognostic biomarkers are useful in allogeneic stem cell transplantation (SCT) to predict survival and relapse outcomes. We sought to derive a prognostic scoring system, which augmented the predictive power of the disease risk index (DRI) by incorporating biomarkers and validating their significance after SCT. The outcomes of overall survival (OS) and relapse were assessed with non-relapse mortality (NRM) treated as a competing risk to relapse. Six hundred and two patients were identified through a retrospective analysis of allogeneic SCT recipients for haematological malignancy between 2000 and 2013 in a single centre...
May 15, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28504663/a-new-time-dependent-approach-for-assessment-of-the-impact-of-invasive-aspergillosis-shows-effect-on-short-but-not-on-long-term-survival-of-patients-with-aml-or-high-risk-mds
#4
R J van de Peppel, P A von dem Borne, S le Cessie, M G J de Boer
Invasive aspergillosis (IA) has been reported to yield high mortality rates. Patients with an unfavourable prognostic haematological disease not only have a higher probability of developing IA but are also more likely to die due to causes directly related to the underlying disease. This complexity of risk mechanisms confounds the causal interpretation of IA occurrence and mortality. Full consideration of the changing patient characteristics over time is necessary to obtain reliable estimates of the correlation of IA with mortality...
May 15, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28504662/association-between-pretransplant-iron-overload-determined-by-bone-marrow-pathological-analysis-and-bacterial-infection
#5
A Ohmoto, S Fuji, A Miyagi-Maeshima, S-W Kim, K Tajima, T Tanaka, K Okinaka, S Kurosawa, Y Inamoto, H Taniguchi, T Fukuda
No abstract text is available yet for this article.
May 15, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28504661/circulating-tumor-cells-as-a-biomarker-for-response-to-therapy-in-multiple-myeloma-patients-treated-within-the-gmmg-mm5-trial
#6
S Huhn, N Weinhold, J Nickel, M Pritsch, T Hielscher, M Hummel, U Bertsch, B Huegle-Doerr, M Vogel, R Angermund, M Hänel, H J Salwender, K Weisel, J Dürig, M Görner, H Kirchner, N Peter, U Graeven, F Lordick, M Hoffmann, P Reimer, I W Blau, A Jauch, K Dembowsky, T Möhler, P Wuchter, H Goldschmidt
No abstract text is available yet for this article.
May 15, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28481355/population-pharmacokinetics-of-fludarabine-in-patients-with-aplastic-anemia-and-fanconi-anemia-undergoing-allogeneic-hematopoietic-stem-cell-transplantation
#7
E Mohanan, J C Panetta, K M Lakshmi, E S Edison, A Korula, N A Fouzia, A Abraham, A Viswabandya, V Mathews, B George, A Srivastava, P Balasubramanian
Although hematopoietic stem cell transplantation (HSCT) with a conditioning regimen consisting of fludarabine (F-araA) and cyclophosphamide (Cy) is associated with improved outcome in young patients with aplastic anemia (AA) and Fanconi anemia (FA), several factors limit the success of the procedure. We evaluated the population pharmacokinetics (POPPK) of F-araA and its influence on HSCT outcome in patients (n=53) with AA and FA undergoing HSCT. Patients carrying a 5'-UTR polymorphism in NT5E gene (rs2295890 G>C) exhibited significantly lower plasma F-araA clearance compared to those with wild-type genotype (7...
May 8, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28481354/safety-and-cost-effectiveness-of-outpatient-autologous-transplantation-for-multiple-myeloma-in-asia-single-center-perspective-from-singapore
#8
M B Abid, D Christopher, M A Abid, M L Poon, L K Tan, L P Koh, W J Chng
No abstract text is available yet for this article.
May 8, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28481353/b-cell-activating-factor-baff-plasma-level-at-the-time-of-chronic-gvhd-diagnosis-is-a-potential-predictor-of-non-relapse-mortality
#9
R M Saliba, S Sarantopoulos, C L Kitko, A Pawarode, S C Goldstein, J Magenau, A M Alousi, T Churay, H Justman, S Paczesny, P Reddy, D R Couriel
Biological markers for risk stratification of chronic GvHD (cGvHD) could improve the care of patients undergoing allogeneic hematopoietic stem cell transplantation. Increased plasma levels of B-cell activating factor (BAFF), chemokine (C-X-C motif) ligand 9 (CXCL9) and elafin have been associated with the diagnosis, but not with outcome in patients with cGvHD. We evaluated the association between levels of these soluble proteins, measured by ELISA at the time of cGvHD diagnosis and before the initiation of therapy, with non-relapse-mortality (NRM)...
May 8, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28481352/partial-break-in-tolerance-of-nkg2a-lir-1-single-kir-nk-cells-early-in-the-course-of-hla-matched-kir-mismatched-hematopoietic-cell-transplantation
#10
S Rathmann, C Keck, C Kreutz, N Weit, M Müller, J Timmer, S Glatzel, M Follo, M Malkovsky, M Werner, R Handgretinger, J Finke, P Fisch
Natural killer (NK) cell subpopulations from 8 HLA-matched but killer cell immunoglobulin-like receptor (KIR)/HLA-ligand-mismatched patient-donor pairs were analyzed in the course of allogeneic hematopoietic stem cell transplantation (HCT). The patients' post-transplantation NKG2A(-)/LIR-1(-) NK cells, which expressed only inhibitory KIRs for which the patient had no HLA class I ligands, showed higher cytotoxic capacity than the NKG2A(-)/LIR-1(-) NK cells lacking any inhibitory KIRs that remained tolerant throughout the course of HCT...
May 8, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28481351/dental-status-does-not-predict-infection-during-stem-cell-transplantation-a-single-center-survey
#11
A Guenther, E Losch, M Schiessl, A Schrauder, A Humpe, R Repp, T Nitsche, J Wiltfang, M Gramatzki
No abstract text is available yet for this article.
May 8, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28436979/successful-chimeric-ag-receptor-modified-t-cell-therapy-for-isolated-testicular-relapse-after-hematopoietic-cell-transplantation-in-an-acute-lymphoblastic-leukemia-patient
#12
J Yu, Y Hu, C Pu, Z Liang, Q Cui, H Zhang, Y Luo, J Shi, A Jin, L Xiao, Z Wu, H Huang
No abstract text is available yet for this article.
April 24, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28436978/association-of-hematopoietic-cell-transplantation-specific-comorbidity-index-with-resource-utilization-after-allogeneic-transplantation
#13
L Decook, Y-H Chang, J Slack, D Gastineau, J Leis, P Noel, J Palmer, L Sproat, M Sorror, N Khera
Comorbidities affect clinical outcomes and costs in medicine. The hematopoietic cell transplantation (HCT)-specific comorbidity index (HCT-CI) predicts mortality risk after HCT. Its association with resource utilization (RU) is unknown. In this single-center, retrospective study, we examined the association of HCT-CI with RU (readmissions, length of hospital stay (LOS) and days out of hospital alive (DOHA)) in first 100 days (n=328) and 1 year (n=226) in allogeneic HCT patients from January 2010 to June 2014...
April 24, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28436977/provision-of-long-term-monitoring-and-late-effects-services-following-adult-allogeneic-haematopoietic-stem-cell-transplant-a-survey-of-uk-nhs-based-programmes
#14
A Hamblin, D M Greenfield, M Gilleece, N Salooja, M Kenyon, E Morris, N Glover, P Miller, H Braund, A Peniket, B E Shaw, J A Snowden
Despite international guidelines, optimal delivery models of late effects (LE) services for HSCT patients are unclear from the clinical, organizational and economic viewpoints. To scope current LE service delivery models within the UK NHS (National Health Service), in 2014, we surveyed the 27 adult allogeneic HSCT centres using a 30-question online tool, achieving a 100% response rate. Most LE services were led and delivered by senior physicians (>80% centres). Follow-up was usually provided in a dedicated allograft or LE clinic for the first year (>90% centres), but thereafter attrition meant that only ~50% of patients were followed after 5 years...
April 24, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28436976/rbc-depletion-from-a-pbsc-graft
#15
H Bonig, G Bug
No abstract text is available yet for this article.
April 24, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28436975/haploidentical-stem-cell-transplantation-with-cd3-cd19-depleted-peripheral-stem-cells-for-patients-with-advanced-stage-sickle-cell-disease-and-no-alternative-donor-results-of-a-pilot-study
#16
J Foell, B Pfirstinger, K Rehe, D Wolff, E Holler, S Corbacioglu
No abstract text is available yet for this article.
April 24, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28436974/high-dose-thiotepa-based-chemotherapy-with-autologous-stem-cell-support-in-elderly-patients-with-primary-central-nervous-system-lymphoma-a-european-retrospective-study
#17
E Schorb, C P Fox, K Fritsch, L Isbell, A Neubauer, A Tzalavras, R Witherall, S Choquet, O Kuittinen, D De-Silva, K Cwynarski, C Houillier, K Hoang-Xuan, V Touitou, N Cassoux, J-P Marolleau, J Tamburini, R Houot, V Delwail, G Illerhaus, C Soussain, B Kasenda
In this retrospective multicentre study, we investigated the outcomes of elderly primary central nervous system lymphoma (PCNSL) patients (⩾65 years) who underwent high-dose chemotherapy followed by autologous stem cell transplantation (HDT-ASCT) at 11 centres between 2003 and 2016. End points included remission, progression-free survival (PFS), overall survival (OS) and treatment-related mortality. We identified 52 patients (median age 68.5 years, median Karnofsky Performance Status before HDT-ASCT 80%) who all underwent thiotepa-based HDT-ASCT...
April 24, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28436973/a-review-of-hematopoietic-cell-transplantation-in-china-data-and-trends-during-2008-2016
#18
L-P Xu, D-P Wu, M-Z Han, H Huang, Q-F Liu, D-H Liu, Z-M Sun, L-H Xia, J Chen, H-X Wang, C Wang, C-F Li, Y-R Lai, J-M Wang, D-B Zhou, H Chen, Y-P Song, T Liu, K-Y Liu, X-J Huang
Hematopoietic cell transplantation (HCT) activity in China was surveyed to assess its current status. A record number of HCTs (21 884: 16 631 allogeneic (76%) and 5253 autologous (24%)) were reported by 76 centers in China between 1 January 2008 and 30 June 2016. HCT trends included continued growth in transplant activity, a continued rapid increase in haploidentical donors (HID), and slower growth for unrelated donors, matched-related donors (MRD) and cord blood transplantation (CBT). The proportion of HID HCT among allogeneic HCTs increased from 29...
April 24, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28436972/allogeneic-transplantation-in-primary-refractory-aml
#19
P Ferguson, C Craddock
No abstract text is available yet for this article.
April 24, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28436971/when-selecting-a-cord-blood-unit-from-a-firstborn-donor-verify-that-the-patient-shares-an-ag-with-the-unit-that-is-foreign-to-the-mother-of-the-donor
#20
J J van Rood, A Brand, A Scaradavou, F H Claas, M Oudshoorn, C E Stevens
No abstract text is available yet for this article.
April 24, 2017: Bone Marrow Transplantation
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