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Bone Marrow Transplantation

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https://www.readbyqxmd.com/read/28218757/allogeneic-stem-cell-transplantation-for-refractory-acute-myeloid-leukemia-in-pediatric-patients-the-uk-experience
#1
P O'Hare, G Lucchini, M Cummins, P Veys, M Potter, S Lawson, A Vora, R Wynn, A Peniket, K Kirkland, R Pearce, J Perry, P J Amrolia
We report outcomes for 44 children who underwent stem cell transplantation (SCT) for refractory AML in the UK between 2000 and 2012. Median age at SCT was 11.5 years. Twenty-three patients had primary refractory and 21 relapsed refractory AML. Refractory disease was confirmed by cytogenetics/molecular genetics in 24 cases. Median follow-up of the whole cohort is 6.8 years (2.1-14.9 years). Thirty patients (68%) achieved a CR following SCT. Transplant-related mortality at 1 year was 18%. Acute GVHD incidence was 52% (grade ⩾III 19%), chronic 7%...
February 20, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28218756/untreated-donor-specific-antibodies-against-hla-are-associated-with-poor-outcomes-in-peripheral-blood-haploidentical-hematopoietic-cell-transplantation
#2
J Zou, R Romee, M Slade, D Phelan, J Keller, T Mohanakumar, B J Grossman
No abstract text is available yet for this article.
February 20, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28218755/changes-in-the-incidence-patterns-and-outcomes-of-graft-failure-following-hematopoietic-stem-cell-transplantation-for-hurler-syndrome
#3
S H Lum, W P Miller, S Jones, K Poulton, W Ogden, H Lee, A Logan, D Bonney, T C Lund, P J Orchard, R F Wynn
Hematopoietic stem cell transplantation (HSCT) is the standard of care in children with Hurler syndrome (HS) as it is the only therapy that can arrest disease progression. We examined the incidence, patterns and outcomes of graft failure in all HS children undergoing first HSCT at the Royal Manchester Children's Hospital or the University of Minnesota Children's Hospital from 1983 to 2016. Implementation of busulfan pharmacokinetic monitoring started in 2004 in both institutions. Two hundred and forty HS children were included in this analysis (historical era (pre-2004), n=131; current era (post 2004), n=109)...
February 20, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28218754/cmv-viral-load-in-bronchoalveolar-lavage-for-diagnosis-of-pneumonia-in-allogeneic-hematopoietic-stem-cell-transplantation
#4
L Iglesias, M M Perera, L Torres-Miñana, M J Pena-López
The objective of this report is to analyze the value of CMV viral load (VL) in bronchoalveolar lavage (BAL) in recipients of allogeneic hematopoietic stem cell transplantation (AHSCT) and to analyze the concordance between CMV quantification in plasma and BAL samples. Fifty-six patients were included; in 16 (28.6%) patients with symptoms of lung disease a BAL sample was collected, 7 (43.7%) patients had a VL >150 copies/mL (six had probable CMV pneumonia). Patients with CMV pneumonia were female (100%), of median age 53...
February 20, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28218753/a-short-tale-of-blood-kidney-and-brain-bk-virus-encephalitis-in-an-allogeneic-stem-cell-transplant-recipient
#5
C Bourlon, S Alamoudi, D Kumar, A Viswabandya, S Thyagu, F V Michelis, D D-H Kim, J H Lipton, H A Messner, U Deotare
No abstract text is available yet for this article.
February 20, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28218752/the-hla-conundrum-in-bone-marrow-transplantation-correct-interpretation-of-anti-hla-antibodies-in-haploidentical-donor-selection
#6
A L Dias, S Hashmi, W Hogan, N Baig, L Wakefield, J Kreuter, M J Gandhi
No abstract text is available yet for this article.
February 20, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28218751/scleral-lenses-for-severe-chronic-gvhd-related-keratoconjunctivitis-sicca-a-retrospective-study-by-the-sfgm-tc
#7
L Magro, J Gauthier, M Richet, M Robin, S Nguyen, F Suarez, J-H Dalle, T Fagot, A Huynh, M-T Rubio, R Oumadely, S Vigouroux, N Milpied, A Delcampe, I Yakoub-Agha
Chronic GvHD-related keratoconjunctivitis sicca (cGvHD-related KCS) can significantly alter the quality of life of patients after allogeneic hematopoietic stem cell transplantation. The aim of this work was to assess the efficacy and tolerability of scleral lenses to treat severe cGvHD-related KCS. In this retrospective, multicenter study, we included 60 consecutive patients diagnosed with cGvHD-related KCS and fitted with scleral lenses. Patients were evaluated at baseline and at 2 months with the following tests: the Ocular Surface Disease Index (OSDI) to assess quality of life, the Oxford score to grade corneal damage and the logarithm of minimal angle of resolution (Log MAR) scale to determine visual acuity...
February 20, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28194031/hematopoietic-stem-cell-remobilization-with-vinorelbine-and-filgrastim-in-aml
#8
V Blum, A D Heini, U Novak, B M Taleghani, G M Baerlocher, K Leibundgut, K Seipel, Y Banz, M Bargetzi, T Pabst
No abstract text is available yet for this article.
February 13, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28194030/increased-incidence-of-oral-and-gastrointestinal-secondary-cancer-after-allogeneic-hematopoietic-stem-cell-transplantation
#9
Y Tanaka, S Kurosawa, K Tajima, T Tanaka, R Ito, Y Inoue, K Okinaka, Y Inamoto, S Fuji, S-W Kim, R Tanosaki, T Yamashita, T Fukuda
No abstract text is available yet for this article.
February 13, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28165448/effective-desensitization-of-donor-specific-hla-antibodies-using-platelet-transfusion-bearing-targeted-hla-in-a-case-of-hla-mismatched-allogeneic-stem-cell-transplantation
#10
T Yamashita, K Ikegame, H Kojima, H Tanaka, K Kaida, T Inoue, H Ogawa
No abstract text is available yet for this article.
February 6, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28134923/transforming-growth-factor-%C3%AE-1-functional-polymorphisms-in-myeloablative-sibling-hematopoietic-stem-cell-transplantation
#11
M Berro, M V Palau Nagore, M M Rivas, P Longo, C Foncuberta, A Vitriú, G Remaggi, J Martínez Rolon, G Jaimovich, A Requejo, L Feldman, K Padros, M B Rodríguez, B E Shaw, I Larripa, C B Belli, G D Kusminsky
Hematopoietic stem cell transplantation (HSCT) with sibling donors (s.d.) is a life-saving intervention for patients with hematological malignancies. Numerous genetic factors have a role in transplant outcome. Several functional polymorphisms have been identified in TGF-β1 gene, such as single-nucleotide polymorphism (SNP) at +29C>T within exon 1. Two hundred and forty five patient/donor pairs who underwent a s.d. HSCT in our centers were genotyped for this SNP. In the myeloablative cohort, +29CC donors were associated with an increase in severe chronic GvHD (32% vs 16%, hazard ratio (HR) 9...
January 30, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28134922/maldi-tof-ms-in-post-transplant-bloodstream-infections-reliable-identification-of-causative-bacteria-in-the-neutropenic-phase
#12
M Kanaya, Y Hayashi, D Hashimoto, T Endo, J Sugita, H Ohigashi, J Hashiguchi, T Matsukawa, S Matsuoka, M Kosugi-Kanaya, H Goto, M Onozawa, K Kahata, K Fujimoto, T Kondo, K Akizawa, H Shibuya, C Shimizu, T Teshima
No abstract text is available yet for this article.
January 30, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28134921/improving-outcomes-after-allogeneic-hematopoietic-cell-transplantation-for-hodgkin-lymphoma-in-the-brentuximab-vedotin-era
#13
L Hegerova, Q Cao, A Lazaryan, B L McClune, D J Weisdorf, C G Brunstein, V Bachanova
Allogeneic hematopoietic cell transplantation (alloHCT) remains a valuable treatment alternative for relapsed/refractory (R/R) Hodgkin lymphoma (HL). Data on alloHCT outcomes in the era of new HL therapies are needed. We evaluated 72R/R HL patients who received reduced intensity conditioning alloHCT and compared the time periods 2009-2013 (n=20) with 2000-2008 (n=52). Grafts included HLA-matched sibling (35%), unrelated donor (8%) and umbilical cord blood (56%). In the recent period, patients more often received brentuximab vedotin (BV, 60% vs 2%), had fewer comorbidities (Sorror index 0: 60% vs 12%) and were in complete remission (50% vs 23%)...
January 30, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28134920/lymphocyte-expansion-after-unrelated-cord-blood-allogeneic-stem-cell-transplantation-in-adults
#14
Y Le Bris, T Guillaume, A Ménard, M Illiaquer, J Martin, S Malard, A Duquesne, P Peterlin, C Debord, N Robillard, M Eveillard, S Wuillème, J Delaunay, M Mohty, A Garnier, P Moreau, M C Béné, P Chevallier
Limited information is available regarding the incidence and features of lymphocyte expansions after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Large granular lymphocytes (LGL) expansions have been reported after bone marrow or peripheral blood, but not after unrelated cord blood (UCB) allo-HSCT, associated with indolent clinical courses and favorable outcomes. Here, we considered 85 recipients of UCB allo-HSCT to more broadly define the impact of lymphocytosis, not limited to LGL. Sustained lymphocytosis was observed in 21 (25%) patients at a median onset of 12...
January 30, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28112753/is-day-1-omission-of-methotrexate-associated-with-higher-incidence-of-acute-gvhd-in-hematopoietic-stem-cell-transplantation
#15
E Leon-Rodriguez, M M Rivera-Franco, A Campos-Castro
No abstract text is available yet for this article.
January 23, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28112752/carmustine-replacement-in-intensive-chemotherapy-preceding-reinjection-of-autologous-hscs-in-hodgkin-and-non-hodgkin-lymphoma-a-review
#16
REVIEW
G Damaj, J Cornillon, K Bouabdallah, R Gressin, S Vigouroux, T Gastinne, F Ranchon, H Ghésquières, G Salles, I Yakoub-Agha, E Gyan
High-dose chemotherapy preceding autologous hematopoietic stem cell transplantation (auto-HSCT) is one treatment option for patients with Hodgkin (HL) or non-Hodgkin lymphoma (NHL). The most frequently used intensive chemotherapy is a combination of carmustine (BCNU), etoposide, cytarabine and melphalan (BEAM). However, BCNU is consistently in short supply, and there has been a recent dramatic increase in its cost, necessitating the utilization of conditioning alternatives. The busulfan-based conditioning regimen known as the busulfan-cyclophosphamide-etoposide (BuCyE) combination is the second most-studied conditioning regimen worldwide after BEAM, and it exhibits a benefit/risk ratio that is comparable to that of BEAM...
January 23, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28112751/going-home-for-the-holidays-take-a-shortcut
#17
L Metheny, M de Lima
No abstract text is available yet for this article.
January 23, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28112750/investigating-the-temporal-course-relevance-and-risk-factors-of-fatigue-over-5-years-a-prospective-study-among-patients-receiving-allogeneic-hsct
#18
P Esser, K Kuba, A Mehnert, A Schwinn, L Schirmer, F Schulz-Kindermann, M Kruse, U Koch, A R Zander, N Kröger, G Schilling, H Götze, A Scherwath
Although allogeneic hematopoietic stem cell transplantation (HSCT) features severe physical and psychological strain, no previous study has prospectively investigated fatigue beyond 3 years after transplantation. We investigated the temporal course of fatigue over 5 years, compared patients with the general population (GP) and tested for treatment- and complication-related risk factors. Patients were assessed before conditioning (T0, N=239) and at 100-day (T1, N=150), 1-year (T2, N=102) and 5-year (T3, N=45) follow-up...
January 23, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28112749/reduced-intensity-conditioning-allogeneic-hematopoietic-cell-transplantation-for-younger-patients-with-acute-myeloid-leukemia-a-registry-based-study
#19
M Yanada, S Kurosawa, T Kobayashi, Y Ozawa, H Kanamori, N Kobayashi, M Sawa, H Nakamae, N Uchida, H Hashimoto, T Fukuda, M Hirokawa, Y Atsuta, S Yano
Clinical efficacy of allogeneic hematopoietic cell transplantation (HCT) using reduced-intensity conditioning (RIC) for younger patients remains unclear. We therefore performed a retrospective registry-based study to evaluate outcomes for patients with AML aged between 16 and 49 years who underwent RIC allogeneic HCT. Patients receiving RIC (N=125) showed significantly worse survival than those receiving myeloablative conditioning (MAC; N=1,554) (47.7% for RIC and 54.2% for MAC at 4 years, P=0.047). However, the difference became marginal after adjustment for patient characteristics (P=0...
January 23, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28112748/outcome-after-failure-of-allogeneic-hematopoietic-stem-cell-transplantation-in-children-with-acute-leukemia-a-study-by-the-soci%C3%A3-t%C3%A3-francophone-de-greffe-de-moelle-et-de-th%C3%A3-rapie-cellulaire-sfgm-tc
#20
C Roux, K Tifratene, G Socié, C Galambrun, Y Bertrand, F Rialland, C Jubert, C Pochon, C Paillard, A Sirvent, B Nelken, J P Vannier, C Freycon, Y Beguin, N Raus, I Yakoub-Agha, M Mohty, J-H Dalle, G Michel, C Pradier, R Peffault de Latour, P-S Rohrlich
Allogeneic hematopoietic stem cell transplantation (SCT) contributes to improved outcome in childhood acute leukemia (AL). However, therapeutic options are poorly defined in the case of post-transplantation relapse. We aimed to compare treatment strategies in 334 consecutive children with acute leukemia relapse or progression after SCT in a recent 10-year period. Data could be analyzed in 288 patients (157 ALL, 123 AML and 8 biphenotypic AL) with a median age of 8.16 years at transplantation. The median delay from first SCT to relapse or progression was 182 days...
January 23, 2017: Bone Marrow Transplantation
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