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Bone Marrow Transplantation

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https://www.readbyqxmd.com/read/29339800/haploidentical-hematopoietic-stem-cell-transplant-for-patients-with-sickle-cell-disease-using-thiotepa-fludarabine-thymoglobulin-low-dose-cyclophosphamide-200-cgy%C3%A2-tbi-and-post-transplant-cyclophosphamide
#1
LETTER
Haydar Frangoul, Misty Evans, Julie Isbell, Katie Bruce, Jennifer Domm
No abstract text is available yet for this article.
January 16, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29339799/complementary-therapies-for-fatigue-after-hematopoietic-stem-cell-transplantation-an-integrative-review
#2
Mohamad Baydoun, Debra L Barton
Fatigue after hematopoietic stem cell transplantation (HSCT) is a persistent problem that limits activities and causes distress. Complementary therapies have shown promising results in improving fatigue in several patient populations. However, it is unknown whether they have the same effect on fatigue in the HSCT population. This integrative review aimed to explore the literature that evaluated complementary therapies for fatigue among HSCT patients. Only eight studies were considered eligible for inclusion in this review...
January 16, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29335633/long-term-survival-among-patients-who-are-disease-free-at-1-year-post-allogeneic-hematopoietic-cell-transplantation-a-single-center-analysis-of-389-consecutive-patients
#3
Melhem M Solh, Asad Bashey, Scott R Solomon, Lawrence E Morris, Xu Zhang, Stacey Brown, H Kent Holland
Allogeneic hematopoietic cell transplantation (HCT) is associated with significant morbidity and mortality especially in the first year after HCT. In this study, we examine the long-term outcomes of patients who survived at least one year post HCT without evidence of relapse. We analyzed the records for 389 consecutive patients receiving an allogeneic transplant from 2005 to 2016 from a MRD, MUD, or haploidentical donor, who were alive and disease free at one year post-transplant. Patient characteristics and outcome parameters were extracted from our institutional database where they had been prospectively entered...
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29335632/long-term-outcome-analysis-of-reduced-intensity-allogeneic-stem-cell-transplantation-in-patients-with-mantle-cell-lymphoma-a-retrospective-study-from-the-ebmt-lymphoma-working-party
#4
Stephen P Robinson, Ariane Boumendil, Herve Finel, Karl S Peggs, Patrice Chevallier, Jorge Sierra, Jürgen Finke, Xavier Poiré, Natacha Maillard, Noël Milpied, Ibrahim Yakoub-Agha, Mickey Koh, Nicolaus Kröger, Arnon Nagler, Yener Koc, Sascha Dietrich, Silvia Montoto, Peter Dreger
Reduced-intensity allogeneic stem cell transplantation (RIST) is usually reserved for patients with mantle cell lymphoma who relapse after an autoSCT. However, the long-term efficacy of RIST and its curative potential have not been clearly demonstrated. We studied the long-term outcome of patients receiving a RIST for MCL as reported to the EBMT. A total of 324 patients, median age 57 years (range 31-70), underwent a RIST between 2000 and 2008; 43% of the patients had received >3 lines of prior therapy, including an autoSCT in 46%...
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29335631/impact-of-hla-allele-mismatch-at-hla-a-b-c-drb1-and-dqb1-on-outcomes-in-haploidentical-stem-cell-transplantation
#5
Ming-Rui Huo, Xu-Ying Pei, Dan Li, Ying-Jun Chang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang
The impact of human leukocyte antigen (HLA) allele mismatch on transplant outcomes in haploidentical stem cell transplantation (haplo-SCT) has not been established. We retrospectively studied 595 patients with hematologic malignancy who received haplo-SCT. The impact of multiple HLA allele mismatches (HLA-A, -B, -C, -DRB1, and -DQB1) and each HLA allele mismatch on transplant outcomes was analyzed. Greater number of HLA allele disparity does not appear worsen outcome. As for each HLA locus, HLA-A mismatch correlated with decreased rate of platelet engraftment (HR 0...
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29335630/haploidentical-stem-cell-transplantation-cures-autoimmune-hepatitis-and-cerebrovascular-disease-in-a-patient-with-sickle-cell-disease
#6
LETTER
Elisabetta Calore, Antonio Marzollo, Mara Cananzi, Marco Pizzi, Massimo Rugge, Sara Rossin, Renzo Manara, Manuela Tumino, Giuseppe Basso, Raffaella Colombatti, Laura Sainati
No abstract text is available yet for this article.
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29335629/a-prospective-randomized-evaluation-of-the-feasibility-of-exergaming-on-patients-undergoing-hematopoietic-stem-cell-transplantation
#7
Helge Schumacher, Sabrina Stüwe, Peter Kropp, Doreen Diedrich, Sebastian Freitag, Nico Greger, Christian Junghanss, Mathias Freund, Inken Hilgendorf
The positive effects of physical and sports therapy for strain dependent physical practice and improved quality of life (QoL) are well known. Nevertheless, the available capacities and problem-oriented therapies in the setting of hematopoietic stem cell transplantation (HSCT) are limited. We conducted a prospective, randomized study among 42 HSCT recipients in order to investigate the influence of exergaming on Nintendo Wii® or classical physiotherapy (PT) on physical fitness and psychological well-being. The trial included evaluation of muscle strength, endurance, physical activity, distress, QoL, anxiety, and depression...
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29335628/endothelial-cell-damage-in-idiopathic-pneumonia-syndrome
#8
LETTER
Thomas Altmann, James Slack, Mary A Slatter, Christopher O'Brien, Andrew Cant, Matthew Thomas, Malcolm Brodlie, Srinivas Annavarapu, Andrew R Gennery
No abstract text is available yet for this article.
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29335627/a-comparison-of-attitudes-toward-hsct-and-survival-estimations-post-hsct-across-two-pediatric-hematology-oncology-and-intensive-care-departments-in-canada
#9
LETTER
Serge Sultan, Marie-France Vachon, Marie-Claude Charette, Émélie Rondeau, Bryan Provost, Guillaume Émériaud, Pierre Teira
No abstract text is available yet for this article.
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29335626/using-liver-elastography-to-diagnose-sinusoidal-obstruction-syndrome-in-pediatric-patients-undergoing-hematopoetic-stem-cell-transplant
#10
Naresh Reddivalla, Amie L Robinson, Kimberly J Reid, Mohamed A Radhi, Jignesh Dalal, Erin K Opfer, Sherwin S Chan
Sinusoidal obstruction syndrome (SOS) is a potentially fatal complication of hematopoietic stem cell transplantation (HSCT). Traditional ultrasound (US) has poor sensitivity and specificity. US shear wave elastography (SWE) is a newer technology that measures liver stiffness. This is a single-institution, prospective cohort study evaluating SWE in patients younger than 21 years who received HSCT from December 2015 through June 2017. SOS was defined using the modified Seattle criteria. Subjects had US with SWE at three scheduled time points...
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29335625/the-european-society-for-blood-and-marrow-transplantation-ebmt-consensus-guidelines-for-the-detection-and-treatment-of-donor-specific-anti-hla-antibodies-dsa-in-haploidentical-hematopoietic-cell-transplantation
#11
REVIEW
Stefan O Ciurea, Kai Cao, Marcelo Fernadez-Vina, Piyanuch Kongtim, Monzr Al Malki, Ephraim Fuchs, Leo Luznik, Xiao-Jun Huang, Fabio Ciceri, Franco Locatelli, Franco Aversa, Luca Castagna, Andrea Bacigalupo, Massimo Martelli, Didier Blaise, Rupert Handgretinger, Denis-Claude Roy, Paul O'Donnell, Asad Bashey, Hillard M Lazarus, Karen Ballen, Bipin N Savani, Mohamad Mohty, Arnon Nagler
Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch...
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29335624/beneficial-impact-of-low-dose-rabbit-anti-thymocyte-globulin-in-unrelated-hematopoietic-stem-cell-transplantation-focusing-on-difference-between-stem-cell-sources
#12
LETTER
Takafumi Shichijo, Shigeo Fuji, Kinuko Tajima, Hiroyuki Kubo, Kenji Nozaki, Tadahiro Honda, Junko Yamaguchi, Ichiro Kawashima, Akihisa Kawajiri, Tomonari Takemura, Akio Onishi, Ayumu Ito, Takashi Tanaka, Yoshihiro Inamoto, Saiko Kurosawa, Sung-Won Kim, Takahiro Fukuda
No abstract text is available yet for this article.
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29335623/sinusoidal-obstruction-syndrome-veno-occlusive-disease-after-high-dose-intravenous-busulfan-melphalan-conditioning-therapy-in-high-risk-ewing-sarcoma
#13
Massimo Eraldo Abate, Anna Paioli, Sivlia Cammelli, Marilena Cesari, Alessandra Longhi, Emanuela Palmerini, Stefano Ferrari, Elisa Carretta, Piero Picci, Fabio Piscaglia
This mono-institutional observational study was conducted to determine incidence, severity, risk factors, and outcome of sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) in high-risk Ewing sarcoma (ES) patients treated with intravenous busulfan and melphalan (BU-MEL) followed by autologous stem cell transplantation (ASCT). During the past 10 years, 75 consecutive ES patients resulted evaluable for the analysis. After diagnosis of SOS/VOD, defibrotide therapy was started as soon as the medication was available...
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29335622/topical-vitamin-d-analog-for-chronic-graft-versus-host-disease-of-the-skin
#14
LETTER
Gregory Wallace, Kasiani C Myers, Ashley Teusink-Cross, Stella M Davies, Pooja Khandelwal, Sonata Jodele
No abstract text is available yet for this article.
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29335621/prognostic-relevance-of-dnmt3a-r882-mutations-in-aml-patients-undergoing-non-myeloablative-conditioning-hematopoietic-stem-cell-transplantation
#15
LETTER
Laura K Schmalbrock, Lynn Bonifacio, Marius Bill, Madlen Jentzsch, Karoline Schubert, Juliane Grimm, Michael Cross, Thoralf Lange, Vladan Vucinic, Wolfram Pönisch, Gerhard Behre, Georg-Nikolaus Franke, Dietger Niederwieser, Sebastian Schwind
No abstract text is available yet for this article.
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29334367/unmanipulated-haploidentical-transplantation-conditioning-with-busulfan-cyclophosphamide-and-anti-thymoglobulin-for-adult-severe-aplastic-anaemia
#16
L-P Xu, Z-L Xu, F-R Wang, X-D Mo, T-T Han, W Han, Y-H Chen, Y-Y Zhang, J-Z Wang, Y Wang, C-H Yan, Y-Q Sun, F-F Tang, X-H Zhang, X-J Huang
We conducted a retrospective analysis to evaluate outcomes of haploidentical transplantation in adult severe aplastic anaemia (SAA) patients. Fifty-one adults received haploidentical transplantation between May 2011 and December 2016. Patients were administered busulfan (Bu), cyclophosphamide (Cy) and anti-thymoglobulin (ATG) as conditioning regimens, followed by bone marrow and peripheral blood transplantation. The patients' median age was 25 years. Forty-nine patients survived for more than 28 days and all achieved donor myeloid engraftment...
January 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29330406/adjuvant-role-of-septifast-to-improve-the-diagnosis-of-sepsis-in-a-large-cohort-of-hematological-patients
#17
Raffaella Greco, Maria Chiara Barbanti, Nicasio Mancini, Lara Crucitti, Chiara Oltolini, Alessandra Forcina, Francesca Lorentino, Luca Vago, Carlo Messina, Daniela Clerici, Mara Morelli, Fabio Giglio, Maria Teresa Lupo Stanghellini, Laura Infurnari, Matteo G Carrabba, Sarah Marktel, Andrea Assanelli, Paolo Scarpellini, Massimo Bernardi, Jacopo Peccatori, Consuelo Corti, Massimo Clementi, Fabio Ciceri
Febrile neutropenia and sepsis are common and life-threatening complications in hematological diseases. This study was performed retrospectively in 514 patients treated for febrile neutropenia at our institute, to investigate the clinical usefulness of a molecular tool, LightCycler® SeptiFast test (SF), to promptly recognize pathogens causing sepsis in hematological patients. We collected 1837 blood samples of 514 consecutive hematological patients. The time of processing is short. Overall, 757 microorganisms in 663 episodes were detected by molecular test and standard blood cultures (BC): 73...
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29330405/better-outcome-with-haploidentical-over-hla-matched-related-donors-in-patients-with-hodgkin-s-lymphoma-undergoing-allogeneic-haematopoietic-cell-transplantation-a-study-by-the-francophone-society-of-bone-marrow-transplantation-and-cellular-therapy
#18
Jordan Gauthier, Xavier Poiré, Anne-Claire Gac, Mathieu Leclerc, Thierry Guillaume, Yves Chalandon, Stéphanie Nguyen, Edouard Forcade, Caroline Régny, Jacques-Olivier Bay, Ali Bazarbachi, Pierre-Simon Rohrlich, Anne Huynh, Jonathan Farhi, Tony Marchand, Jean-Valère Malfuson, Sylvain Pilorge, Hélène Labussière-Wallet, Cécile Renard, Luc-Matthieu Fornecker, Marie Detrait, Rémy Duléry, Jérémy Delage, Anne-Lise Ménard, Amandine Charbonnier, Brigitte Nelken, Charlotte Jubert, Felipe Suarez, Régis Peffault de la Tour, Yves Beguin, Hélène Schoemans, Didier Blaise, Ibrahim Yakoub-Agha
The question of the best donor type between haploidentical (HAPLO) and matched-related donors (MRD) for patients with advanced HL receiving an allogeneic hematopoietic cell transplantation (allo-HCT) is still debated. Given the lack of data comparing these two types of donor in the setting of non-myeloablative (NMA) or reduced-intensity (RIC) allo-HCT, we performed a multicentre retrospective study using graft-vs.-host disease-free relapse-free survival (GRFS) as our primary endpoint. We analysed the data of 151 consecutive HL patients who underwent NMA or RIC allo-HCT from a HAPLO (N  =  61) or MRD (N  =  90) between January 2011 and January 2016...
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29330404/association-analysis-between-sufu-polymorphism-rs17114808-and-acute-graft-versus-host-disease-after-hematopoietic-stem-cell-transplantation
#19
LETTER
Marie C Katz, Sebastian Michaelis, Darina M Siegmund, Renate Koch, Wolfgang Bethge, Rupert Handgretinger, Markus Mezger
No abstract text is available yet for this article.
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29330403/ruxolitinib-in-steroid-refractory-chronic-graft-versus-host-disease-experience-of-a-single-center
#20
LETTER
Aliana Meneses Ferreira, Carolina Atallah Pontes da Silva, André Domingues Pereira, Roberta Shcolnik Szor, Ana Rita Brito Medeiros da Fonseca, Mariana Gomes Serpa, Erick Menezes Xavier, Michelly Kerly Sampaio de Melo, Yana Novis, Luciana Tucunduva, Vanderson Rocha, Celso Arrais-Rodrigues
No abstract text is available yet for this article.
January 12, 2018: Bone Marrow Transplantation
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