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Bone Marrow Transplantation

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https://www.readbyqxmd.com/read/28805792/immune-reconstitution-in-patients-with-acquired-severe-aplastic-anemia-after-haploidentical-stem-cell-transplantation
#1
X-Y Pei, X-Y Zhao, L-P Xu, Y Wang, X-H Zhang, Y-J Chang, X-J Huang
Immune recovery (IR) after haploidentical stem cell transplantation (haplo-SCT) in severe aplastic anemia (SAA) patients remains relatively unknown. In this study, we examined immune cell subset counts and immunoglobulins in 81 SAA patients from day 30 to day 365 after haplo-SCT. Simultaneously, we determined which factors influence IR and analyzed the effects of immune cell subsets on transplant outcomes. We found that: (i) The reconstitution of different immune cell subsets occurred at different rates after haplo-SCT...
August 14, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28805791/low-circulating-mannan-binding-lectin-levels-correlate-with-increased-frequency-and-severity-of-febrile-episodes-in-myeloma-patients-who-undergo-asct-and-do-not-receive-antibiotic-prophylaxis
#2
E Eleutherakis-Papaiakovou, M-A Dimopoulos, E Kastritis, D Christoulas, M Roussou, M Migkou, M Gavriatopoulou, D Fotiou, I Panagiotidis, D C Ziogas, N Kanellias, C Papadimitriou, E Terpos
Patients with multiple myeloma (MM) who undergo autologous stem cell transplantation (ASCT) are susceptible to severe infections. Low levels of circulating mannan-binding lectin (MBL) are associated with increased risk of infection. In this prospective study, we evaluated 100 patients who underwent ASCT regarding the effect of MBL on the incidence and severity of febrile episodes. Seventeen patients had MBL levels <500 ng/mL (11 received antibiotic prophylaxis and 6 did not). Although there was no statistical difference regarding the development of febrile episodes between patients with low and normal MBL, among 17 patients with low MBL levels, six out of eleven patients who received antibiotic prophylaxis developed a febrile episode compared with six out of six patients who did not receive antibiotic prophylaxis and developed a febrile episode...
August 14, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28805790/successful-reduced-intensity-hematopoietic-cell-transplant-in-a-patient-with-deficiency-of-adenosine-deaminase-2
#3
H Hashem, A Vatsayan, A Gupta, K Nagle, M Hershfield, J Dalal
No abstract text is available yet for this article.
August 14, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28805789/multiple-myeloma-with-extramedullary-disease-impact-of-autologous-stem-cell-transplantation-on-outcome
#4
L Kumar, R Gogi, A K Patel, A Mookerjee, R K Sahoo, P S Malik, A Sharma, S Thulkar, R Kumar, A Biswas, O D Sharma, R Gupta
No abstract text is available yet for this article.
August 14, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28783149/patient-perspectives-on-physical-function-after-allogeneic-hematopoietic-stem-cell-transplantation-a-qualitative-study
#5
A T Freeman, A M Stover, N S Grover, T C Shea, B B Reeve, W A Wood
No abstract text is available yet for this article.
August 7, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28783148/clinical-characteristics-and-outcome-of-human-herpesvirus-6-encephalitis-after-allogeneic-hematopoietic-stem-cell-transplantation
#6
M Ogata, K Oshima, T Ikebe, K Takano, H Kanamori, T Kondo, Y Ueda, T Mori, H Hashimoto, H Ogawa, T Eto, T Ueki, T Miyamoto, T Ichinohe, Y Atsuta, T Fukuda
In this retrospective analysis using the Transplant Registry Unified Management Program, we identified 145 patients with human herpesvirus (HHV)-6 encephalitis among 6593 recipients. The cumulative incidences of HHV-6 encephalitis at 100 days after transplantation in all patients, recipients of bone marrow or PBSCs and recipients of cord blood were 2.3%, 1.6% and 5.0%, respectively. Risk factors identified in multivariate analysis were male sex, type of transplanted cells (relative risk in cord blood transplantation, 11...
August 7, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28783147/marrow-ablative-chemotherapy-followed-by-tandem-autologous-hematopoietic-cell-transplantation-in-pediatric-patients-with-malignant-brain-tumors
#7
J A Guerra, G Dhall, A Marachelian, E Castillo, J Malvar, K Wong, R Sposto, J L Finlay
To improve survival in young children with malignant brain tumors, irradiation-avoiding or -minimizing marrow-ablative chemotherapy (HDCx) with autologous hematopoietic cell transplantation (AuHCT) has been investigated. We evaluated the outcome of 44 children with malignant brain tumors treated with HDCx and tandem AuHCT at Children's Hospital Los Angeles between June 1999 and July 2012. Forty-four children with malignant brain tumors were studied. Twenty-one had medulloblastoma/primitive neuro-ectodermal tumor, eight atypical teratoid/rhabdoid tumor (ATRT), five high-grade glioma, four malignant germ cell tumor, three ependymoma and three choroid plexus carcinoma...
August 7, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28783146/mesenchymal-stromal-cells-for-steroid-refractory-acute-gvhd
#8
C Fernández-Maqueda, R Gonzalo-Daganzo, C Regidor, T Martín-Donaire, R Sánchez, J L Bueno, G Bautista, A De Liglesia, Y Gutiérrez, M García-Berciano, R Forés, A Royuela, M N Fernández, R F Duarte, J R Cabrera-Marín
No abstract text is available yet for this article.
August 7, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28783145/is-there-any-role-for-physical-therapy-in-chronic-gvhd
#9
J Mohammed, B N Savani, A El-Jawahri, J Vanderklish, A L Cheville, S K Hashmi
Chronic GvHD is the leading cause of non-relapse mortality in recipients of hematopoietic cell transplantation. Although the benefit of physical therapy (PT) has been reported in some GvHD studies, a literature gap is identified in demonstrating the exact role of different types of PT interventions and their impact on GvHD outcomes. An electronic search was undertaken using 13 peer-reviewed databases from 1994 to 2016. JADAD scoring method was used to score the quality of articles. PT interventions utilized for non-GvHD aspects of transplantation were excluded...
August 7, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28783144/immune-mediated-cytopenia-in-pediatric-primary-immune-deficiency-patients-following-hsct
#10
J H Chewning, I Aban, H L Haines, R Brown, H H Buchanan, F D Goldman
No abstract text is available yet for this article.
August 7, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28783143/unrelated-cord-blood-transplantation-in-aplastic-anemia-is-anti-thymocyte-globulin-indispensable-for-conditioning
#11
K Kudo, H Muramatsu, A Narita, N Yoshida, R Kobayashi, H Yabe, M Endo, M Inoue, J Hara, S Kounami, J Inagaki, Y Hashii, K Kato, K Tabuchi, S Kojima
No abstract text is available yet for this article.
August 7, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28783142/intractable-cerebral-nocardia-mexicana-in-a-gvhd-patient-successfully-treated-with-linezolid
#12
A Majeed, A Mushtaq, T Zangeneh, R E Ramahi, S Batool, H Khan, A Latif, V Kapoor, F Anwer
No abstract text is available yet for this article.
August 7, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28783141/haematopoietic-stem-cell-transplantation-induces-severe-dysbiosis-in-intestinal-microbiota-of-paediatric-all-patients
#13
K Lähteenmäki, P Wacklin, M Taskinen, E Tuovinen, O Lohi, J Partanen, J Mättö, K Vettenranta
No abstract text is available yet for this article.
August 7, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28759027/higher-rates-of-relapse-in-maternal-recipients-of-haploidentical-hematopoietic-stem-cell-transplantation-from-adult-offspring-donors-for-aml-and-myelodysplastic-syndrome
#14
P R Geethakumari, B Leiby, R Nair, S O Alpdogan, M Carabasi, J Filicko-O'Hara, S Gaballa, M Kasner, T Klumpp, U Martinez-Outschoorn, N Palmisiano, J L Wagner, P Porcu, N Flomenberg, D Grosso
No abstract text is available yet for this article.
July 31, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28759026/association-between-gvhd-and-nivolumab-in-the-fda-adverse-event-reporting-system
#15
Y Oshima, T Tanimoto, K Yuji, A Tojo
No abstract text is available yet for this article.
July 31, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28759025/diagnosis-and-severity-criteria-for-sinusoidal-obstruction-syndrome-veno-occlusive-disease-in-pediatric-patients-a-new-classification-from-the-european-society-for-blood-and-marrow-transplantation
#16
S Corbacioglu, E Carreras, M Ansari, A Balduzzi, S Cesaro, J-H Dalle, F Dignan, B Gibson, T Guengoer, B Gruhn, A Lankester, F Locatelli, A Pagliuca, C Peters, P G Richardson, A S Schulz, P Sedlacek, J Stein, K-W Sykora, J Toporski, E Trigoso, K Vetteranta, J Wachowiak, E Wallhult, R Wynn, I Yaniv, A Yesilipek, M Mohty, P Bader
The advances in hematopoietic cell transplantation (HCT) over the last decade have led to a transplant-related mortality below 15%. Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication of HCT that belongs to a group of diseases increasingly identified as transplant-related, systemic endothelial diseases. In most cases, SOS/VOD resolves within weeks; however, severe SOS/VOD results in multi-organ dysfunction/failure with a mortality rate >80%. A timely diagnosis of SOS/VOD is of critical importance, given the availability of therapeutic options with favorable tolerability...
July 31, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28737776/therapeutic-salivary-monitoring-of-iv-busulfan-in-patients-undergoing-hematopoietic-stem-cell-transplantation-a-pilot-study
#17
L M Bezinelli, F P Eduardo, D L C de Carvalho, C E Dos Santos Ferreira, E V de Almeida, L R Sanches, I Esteves, P V Campregher, N Hamerschlak, L Corrêa
Individual therapeutic monitoring of busulfan (BU) minimizes its toxicity and improves the therapeutic outcomes during hematopoietic stem cell transplantation (HSCT). For individual dose adjustment, several blood collections are performed that are uncomfortable for patients. The aim of this pilot study was to validate a laboratory method for quantification of BU in saliva and to present the results obtained using this protocol in HSCT patients. We performed analyses of selectivity, precision and accuracy of saliva with standard concentrations of BU using ultra-high-performance liquid chromatography with diode array detection...
July 24, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28737775/fertility-preservation-issues-in-pediatric-hematopoietic-stem-cell-transplantation-practical-approaches-from-the-consensus-of-the-pediatric-diseases-working-party-of-the-ebmt-and-the-international-bfm-study-group
#18
A Balduzzi, J-H Dalle, K Jahnukainen, M von Wolff, G Lucchini, M Ifversen, K T Macklon, C Poirot, T Diesch, A Jarisch, D Bresters, I Yaniv, B Gibson, A M Willasch, R Fadini, L Ferrari, A Lawitschka, A Ahler, N Sänger, S Corbacioglu, M Ansari, R Moffat, A Dalissier, E Beohou, P Sedlacek, A Lankester, C D De Heredia Rubio, K Vettenranta, J Wachowiak, A Yesilipek, E Trigoso, T Klingebiel, C Peters, P Bader
Fertility preservation is an urgent challenge in the transplant setting. A panel of transplanters and fertility specialists within the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation (EBMT) and the International BFM Study Group provides specific guidelines. Patients and families should be informed of possible gender- and age-specific cryopreservation strategies that should be tailored according to the underlying disease, clinical condition and previous exposure to chemotherapy...
July 24, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28737774/outcomes-of-salvage-autologous-stem-cell-transplantation-for-multiple-myeloma-with-cytopenias-and-exposure-to-novel-agents
#19
D Tremblay, G Lancman, E Moshier, N Bar, S Jagannath, A Chari
No abstract text is available yet for this article.
July 24, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28737773/the-incidence-of-atrial-fibrillation-among-patients-with-al-amyloidosis-undergoing-high-dose-melphalan-and-stem-cell-transplantation-experience-at-a-single-institution
#20
M Arun, D Brauneis, G Doros, A C Shelton, J M Sloan, K Quillen, F L Ruberg, V Sanchorawala, C Varga
No abstract text is available yet for this article.
July 24, 2017: Bone Marrow Transplantation
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