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BJU International

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https://www.readbyqxmd.com/read/28083998/late-surgical-correction-of-hypospadias-increases-the-risk-of-complications-a-501-consecutive-patients-series
#1
Sarah Garnier, Olivier Maillet, Barbara Cereda, Margot Ollivier, Clement Jeandel, Sylvie Broussous, Christophe Lopez, Francoise Paris, Pascal Philibert, Cyril Amouroux, Claire Jeandel, Amandine Coffy, Laura Gaspari, Jean Pierre Daures, Charles Sultan, Nicolas Kalfa
OBJECTIVES: To evaluate the outcome of hypospadias surgery according to age and to determine if some complications are age-related. PATIENTS AND METHODS: This retrospective study was based on 722 hypospadiac boys undergoing primary repair. 501 had a urethroplasty and were included. Not only complications requiring an additional procedure were included (stenosis, fistula, dehiscence, relapse of curvature, urethrocele) but also healing troubles, infections, hematomas and detrusor-sphincter dyssynergy...
January 13, 2017: BJU International
https://www.readbyqxmd.com/read/28075543/prognostic-value-of-tissue-based-biomarker-signature-in-clear-cell-renal-cell-carcinoma
#2
Ahmed Q Haddad, Jun-Hang Luo, Laura-Maria Krabbe, Oussama Darwish, Bishoy Gayed, Ramy Youssef, Payal Kapur, Dinesh Rakheja, Yair Lotan, Arthur Sagalowsky, Vitaly Margulis
OBJECTIVE: To improve risk stratification for recurrence prognostication in localized clear cell renal cell carcinoma (ccRCC) patients. PATIENTS AND METHODS: 367 patients with non-metastatic ccRCC were included. The cohort was divided into a training and validation set. Using tissue microarrays, immunostaining was performed for 24 biomarkers representative of key pathways in ccRCC. Using LASSO Cox regression, we identified several markers which were used to construct a risk classifier for risk of disease recurrence...
January 11, 2017: BJU International
https://www.readbyqxmd.com/read/28075516/quantifying-severe-urinary-complications-after-radical-prostatectomy-the-development-and-validation-of-a-surgical-performance-indicator-using-hospital-administrative-data
#3
A Sujenthiran, S C Charman, M Parry, J Nossiter, A Aggarwal, P Dasgupta, H Payne, N W Clarke, P Cathcart, J van der Meulen
OBJECTIVES: To develop and validate a surgical performance indicator based on severe urinary complications that require an intervention within two years after radical prostatectomy (RP) identified in hospital administrative data. PATIENTS AND METHODS: Men who underwent RP between 2008 and 2012 in England were identified using hospital administrative data. A transparent coding-framework based on procedure codes was developed to identify severe urinary complications which were grouped into "stricture", "incontinence" and "other"...
January 11, 2017: BJU International
https://www.readbyqxmd.com/read/28075514/tango-a-screening-tool-to-identify-comorbidities-on-the-causal-pathway-of-nocturia
#4
W F Bower, G E Rose, C F Ervin, J Goldin, D M Whishaw, F Khan
OBJECTIVES: To develop a robust screening metric for use in identifying non-lower urinary tract comorbidities pertinent to the multidisciplinary assessment of patients with nocturia. METHODS: Variables having a significant risk association with nocturia of greater than once per night were identified. Discriminating items from validated and reliable tools measuring these comorbidities were identified. A self-completed 57-item questionnaire was developed and a medical checklist and pertinent clinical measures added...
January 11, 2017: BJU International
https://www.readbyqxmd.com/read/28075510/development-of-a-voided-urine-assay-for-detecting-prostate-cancer-noninvasively-a-pilot-study
#5
Edouard J Trabulsi, Sushil K Tripathi, Leonard Gomella, Charalambos Solomides, Eric Wickstrom, Mathew L Thakur
OBJECTIVE: To validate a hypothesis that prostate cancer (PCa) can be detected noninvasively by a simple and reliable assay by targeting genomic VPAC receptors expressed on malignant PCa cells shed in voided urine. MATERIALS AND METHODS: VPAC receptors were targeted with a specific biomolecule, TP4303, developed in our laboratory. With an IRB "exempt" approval of use of de-identified discarded samples, an aliquot of urine collected as a standard of care, from patients presenting to the urology clinic, (N=207, M= 176, F= 31, 21 years or older) was cytospun...
January 11, 2017: BJU International
https://www.readbyqxmd.com/read/28063191/salvage-high-intensity-focused-ultrasound-hifu-for-locally-recurrent-prostate-cancer-after-failed-radiation-therapy-multi-institutional-analysis-of-418-patients
#6
Sebastien Crouzet, Andreas Blana, Francois J Murat, Gilles Pasticier, Stephen C W Brown, Giario N Conti, Roman Ganzer, Olivier Chapet, Albert Gelet, Christian G Chaussy, Cary N Robertson, Stefan Thuroff, John F Ward
OBJECTIVE: To report the oncological outcome of Salvage high-intensity focused ultrasound (S-HIFU) for locally recurrent prostate cancer (PCa) following External Beam Radiotherapy (EBRT) from a multicenter database. MATERIALS AND METHODS: This retrospective study comprises patients from 9 centers with local recurrent disease following EBRT treated with S-HIFU from 1995 to 2009. Biochemical free survival rates (BFSR) was based on the "Phoenix" definition (nadir+2)...
January 7, 2017: BJU International
https://www.readbyqxmd.com/read/28063195/first-line-non-cytotoxic-therapy-in-chemotherapy-naive-patients-with-metastatic-castration-resistant-prostate-cancer-a-systematic-review-of-ten-randomised-clinical-trials
#7
REVIEW
Michiel H F Poorthuis, Robin W M Vernooij, R Jeroen A van Moorselaar, Theo M de Reijke
OBJECTIVE: To systematically evaluate all available treatment options in chemotherapy-naive patients with metastatic castration-resistant prostate cancer (mCRPC). METHODS: We systematically searched PubMed, EMBASE, and the Cochrane libraries up to March 1, 2016 for peer-reviewed publications on randomised clinical trials (RCTs). RCTs were included if progression-free survival (PFS), overall survival (OS), quality of life (QoL), or adverse events (AEs) were quantitatively evaluated...
January 6, 2017: BJU International
https://www.readbyqxmd.com/read/28058780/cannabinoids-for-treating-neurogenic-lower-urinary-tract-dysfunction-in-patients-with-multiple-sclerosis-a-systematic-review-and-meta-analysis
#8
Nadim Abo Youssef, Marc P Schneider, Livio Mordasini, Benjamin V Ineichen, Lucas M Bachmann, Emmanuel Chartier-Kastler, Jalesh N Panicker, Thomas M Kessler
OBJECTIVES: To systematically review all available evidence on efficacy and safety of cannabinoids for treating neurogenic lower urinary tract dysfunction (NLUTD) in patients with multiple sclerosis (MS). PATIENTS AND METHODS: The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies were identified by electronic search of Cochrane register, Embase, Medline, Scopus (last search on 11 November 2016)...
January 6, 2017: BJU International
https://www.readbyqxmd.com/read/28058776/guideline-of-guidelines-non-muscle-invasive-bladder-cancer
#9
REVIEW
Solomon L Woldu, Aditya Bagrodia, Yair Lotan
Non-muscle invasive bladder cancer (NMIBC) represents the vast majority of bladder cancer diagnoses, however this definition represents a spectrum of disease with a variable clinical course notable for significant risk of recurrence and potential for progression. Management involves risk-adapted strategies of cystoscopic surveillance and intravesical therapy with a goal of bladder preservation when safe to do so. Multiple organizational guidelines exist to help practitioners manage this complicated disease process, however adherence to management principles amongt practicing urologists is reportedly low...
January 6, 2017: BJU International
https://www.readbyqxmd.com/read/28058773/surgical-histopathology-for-suspected-oncocytoma-on-renal-mass-biopsy-a-systematic-review-and-meta-analysis
#10
REVIEW
Hiten D Patel, Sasha C Druskin, Steven P Rowe, Phillip M Pierorazio, Michael A Gorin, Mohamad E Allaf
OBJECTIVE: To estimate the proportion of oncocytic renal neoplasms diagnosed on renal mass biopsy (RMB) confirmed on surgical pathology. MATERIALS AND METHODS: A systematic review of MEDLINE, Embase, and the Cochrane databases (1997-July 1, 2016) was conducted to quantify all cases of reported oncocytic renal neoplasms on RMB suggestive of an oncocytoma. In addition, institutional data was assessed to identify additional cases. Concordance with surgical histopathology (positive predictive value) was evaluated for patients undergoing surgery by performing a meta-analysis...
January 6, 2017: BJU International
https://www.readbyqxmd.com/read/28058757/prostate-health-index-density-improves-detection-of-clinically-significant-prostate-cancer
#11
Jeffrey J Tosoian, Sasha C Druskin, Darian Andreas, Patrick Mullane, Meera Chappidi, Sarah Joo, Kamyar Ghabili, Mufaddal Mamawala, Joseph Agostino, Ballentine H Carter, Alan W Partin, Lori J Sokoll, Ashley E Ross
OBJECTIVES: To explore the utility of prostate health index (PHI) density for detection of clinically-significant prostate cancer (PCa) in a contemporary cohort of men presenting for diagnostic workup of PCa. PATIENTS & METHODS: The study cohort included patients with elevated PSA (>2 ng/ml) and negative digital rectal examination who underwent PHI testing and prostate biopsy at our institution in 2015. Serum markers were prospectively measured per standard clinical pathway...
January 6, 2017: BJU International
https://www.readbyqxmd.com/read/27988986/efficacy-and-safety-of-tadalafil-5mg-once-daily-in-the-treatment-of-lower-urinary-tract-symptoms-associated-with-benign-prostatic-hyperplasia-luts-bph-in-men-aged-75-years-or-older-integrated-analyses-of-pooled-data-from-multinational-randomised-placebo-controlled
#12
Matthias Oelke, Adrian Wagg, Yasushi Takita, Hartwig Büttner, Lars Viktrup
OBJECTIVE: To assess efficacy and safety of tadalafil in men ≥75 years with lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) and additional safety in men ≥75 years with erectile dysfunction (ED). SUBJECTS AND METHODS: Integrated analysis of 12 Phase II-III randomised, double-blind and/or open-label extension studies to evaluate short-term (12-26 weeks) efficacy and short- and longer-term (42-52 weeks) safety in men <75 vs...
December 18, 2016: BJU International
https://www.readbyqxmd.com/read/27988984/safety-and-early-effectiveness-of-robotic-partial-nephrectomy-for-large-angiomyolipomas
#13
Shay Golan, Scott Johnson, Matthew Maurice, Jihad Kaouk, Weil Lai, Benjamin Lee, Steve Kheyfets, Chandru Sundaram, David Cahn, Robert Uzzo, Arieh Shalhav
OBJECTIVES: To evaluate a multicenter series of robotic assisted partial nephrectomy (RAPN) performed for the treatment of large angiomyolipomas (AMLs). MATERIALS AND METHODS: Between 2005-2016, 40 patients with large or symptomatic AMLs underwent RAPN at 5 academic centers in the United States. Patient demographics, AML characteristics, operative and postoperative clinical outcomes were recorded and analyzed. Surgical outcomes were compared between patients who underwent selective arterial embolization (SAE) before RAPN and patients who did not undergo pre-RAPN SAE...
December 18, 2016: BJU International
https://www.readbyqxmd.com/read/27988978/early-surgical-outcomes-and-oncological-results-of-robotic-assisted-partial-nephrectomy-a-multi-centre-study
#14
R Veeratterapillay, S Addla, C Jelley, J Bailie, D Rix, S Bromage, N Oakley, R Weston, N Soomro
OBJECTIVE: To describe a multi-centre experience of robotic assisted partial nephrectomy (RAPN) in Northern England with focus on early surgical outcomes and oncological results. PATIENTS AND METHODS: All consecutive patients undergoing RAPN at four tertiary referral centres in Northern England in the period 2012-2015 were included for analysis. RAPN was performed via a trans-peritoneal approach using standardised technique. Prospective data collection was performed to capture preoperative characteristics (including the R...
December 18, 2016: BJU International
https://www.readbyqxmd.com/read/27987527/development-validation-and-clinical-application-of-pelvic-lymphadenectomy-assessment-and-completion-evaluation-place-intraoperative-assessment-of-lymph-node-dissection-after-robot-assisted-radical-cystectomy-for-bladder-cancer
#15
Ahmed A Hussein, Nobuyuki Hinata, Shiva Dibaj, Paul R May, Justen D Kozlowski, Hassan Abol-Enein, Ronney Abaza, Daniel Eun, Shamim Khan, James L Mohler, Piyush Agrawal, Kamal Pohar, Richard Sarle, Ronald Boris, Sridhar S Mane, Alan Hutson, Khurshid A Guru
OBJECTIVES: To develop a scoring tool, Pelvic Lymphadenectomy Appropriateness and Completion Evaluation (PLACE), to assess the intraoperative completeness and appropriateness of pelvic lymph node dissection (PLND) following robot-assisted radical cystectomy (RARC). METHODS: A panel of 11 open and robotic surgeons developed the content and structure of PLACE. The PLND template was divided into 3 zones. Twenty-one de-identified videos of bilateral robot-assisted PLND were assessed by the 11 experts using PLACE to determine inter-rater reliability (IRR)...
December 17, 2016: BJU International
https://www.readbyqxmd.com/read/27987524/importance-and-outcome-relevance-of-central-pathology-review-in-prostatectomy-specimens-data-from-the-sakk-09-10-randomized-trial-on-prostate-cancer
#16
Pirus Ghadjar, Stefanie Hayoz, Vera Genitsch, Daniel R Zwahlen, Tobias Hölscher, Philipp Gut, Matthias Guckenberger, Guido Hildebrandt, Arndt-Christian Müller, Martin P Putora, Alexandros Papachristofilou, Lukas Stalder, Christine Biaggi-Rudolf, Marcin Sumila, Helmut Kranzbühler, Yousef Najafi, Piet Ost, Ngwa C Azinwi, Christiane Reuter, Stephan Bodis, Kaouthar Khanfir, Volker Budach, Daniel M Aebersold, George N Thalmann
OBJECTIVES: To conduct a central pathology review within a randomized clinical trial on salvage radiation therapy (RT) in the presence of biochemical recurrence after prostatectomy to assess whether this results in shifts of histopathological prognostic factors such as the Gleason Score. PATIENTS AND METHODS: A total of 350 patients were randomized and specimens of 279 (80%) of the patients were centrally reviewed by a dedicated genitourinary pathologist. The Gleason Score, tumor classification and resection margin status were reassessed and compared with the local pathology reports...
December 17, 2016: BJU International
https://www.readbyqxmd.com/read/27981732/clinical-impact-of-68-ga-psma-pet-ct-in-prostate-cancer-patients-with-rising-psa-after-treatment-with-curative-intent-preliminary-analysis-of-a-multidisciplinary-approach
#17
S Albisinni, C Artigas, F Aoun, I Biaou, J Grosman, T Gil, E Hawaux, K Limani, F Otte, A Peltier, S Sideris, N Sirtaine, P Flamen, R van Velthoven
BACKGROUND: To assess the impact of (68) Ga-(HBED-CC)-PSMA (Prostate Specific Membrane Antigen) PET/CT in the clinical management of PCa patients with rising PSA after treatment with curative intent. (68) Ga-PSMA PET/CT scan is a novel molecular imaging technique in the field of prostate cancer (PCa). METHODS: 131 consecutive patients were referred to our center for a (68) Ga-PSMA PET/CT in the setting of recurring prostate cancer. 11/131(8%) presented persistent PSA after radical prostatectomy, while 120/131 (92%) were referred for biochemical recurrence after surgery, radiotherapy or both...
December 15, 2016: BJU International
https://www.readbyqxmd.com/read/27981731/robotic-salvage-retroperitoneal-and-pelvic-lymph-node-dissection-for-node-only-recurrent-prostate-cancer-technique-and-initial-series
#18
Andre Luis de Castro Abreu, Carlos E S Fay, Daniel Park, David Quinn, Tanya Dorff, John Carpten, Peter Kuhn, Parkash Gill, Fabio Almeida, Inderbir S Gill
OBJECTIVES: To describe the technique of robotic high-extended salvage retroperitoneal and pelvic lymphadenectomy (sRPLND+PLND) for 'node-only' recurrent prostate cancer. MATERIALS AND METHODS: Ten patients underwent robotic sRPLND+PLND (09/2015-03/2016) for 'node-only' recurrent prostate cancer, as identified by carbon-11 acetate PET/CT imaging. Our anatomic template extends from bilateral renal artery/vein cranially up to Cloquet's node caudally, completely excising lymphatic-fatty tissue from aorto-caval and iliac vascular trees; RPLND precedes PLND...
December 15, 2016: BJU International
https://www.readbyqxmd.com/read/27981711/sorafenib-dose-escalation-in-treatment-na%C3%A3-ve-patients-with-metastatic-renal-cell-carcinoma-a-non-randomised-open-label-phase-2b-study
#19
Martin E Gore, Robert J Jones, Alain Ravaud, Markus Kuczyk, Tomasz Demkow, Alessandra Bearz, JoAnn Shapiro, U Phillip Strauss, Camillo Porta
OBJECTIVE: To assess the efficacy and safety of sorafenib dose escalation in metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS: Intra-patient dose escalation may enhance the clinical benefit of targeted anticancer agents in metastatic disease. In this non-randomised, open-label, Phase 2b study, treatment-naïve patients with mRCC were initially treated with the standard oral sorafenib dose (400 mg twice daily [BID]). Two dose escalations were planned, each 200 mg BID after 28 d at the prior level...
December 15, 2016: BJU International
https://www.readbyqxmd.com/read/27930856/protection-from-overtreatment-does-a-randomised-trial-finally-answer-the-key-question-in-localised-prostate-cancer
#20
LETTER
Luke L Wang, Christopher J D Wallis, Niranjan Sathianathen, Nathan Lawrentschuk, Declan G Murphy, Robert Nam, Daniel Moon
For the first time we now have a randomised trial comparing active monitoring, surgery and radiation therapy for the management of localised prostate cancer and the investigators are to be congratulated on this highly anticipated landmark study - the Prostate testing for cancer and Treatment (ProtecT) trial[1]. Comparing 545 patients randomised to active monitoring, 553 to radical prostatectomy, and 545 to radiotherapy, at a median follow-up of 10 years the study reports no significant difference in prostate-cancer specific or overall survival amongst the three groups[1]...
December 8, 2016: BJU International
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