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BJU International

Dong Chen, Chonghe Jiang, Xiongfa Liang, Fangling Zhong, Jian Huang, Yongping Lin, Zhijian Zhao, Xiaolu Duan, Guohua Zeng, Wenqi Wu
OBJECTIVES: To obtain more accurate and rapid predictors for postoperative infections following percutaneous nephrolithotomy (PCNL) in complex kidney stone patients, and provide evidence for early prevention and treatment of postoperative infections. MATERIALS AND METHODS: A total of 802 complex kidney stone patients undergone PCNL from September 2016 to September 2017 were recruited. Urine tests, urine cultures and stone cultures were performed, the perioperative data were prospectively recorded...
July 14, 2018: BJU International
Maxim J McKibben, Nabeel Shakir, Joceline S Fuchs, Jeremy M Scott, Allen F Morey
INTRODUCTION AND OBJECTIVES: To compare long term outcomes and erosion rates of 3.5 cm artificial urinary sphincter (AUS) cuffs versus larger cuffs among men with stress urinary incontinence (SUI), with and without a history of pelvic radiation. MATERIALS AND METHODS: We reviewed the records of all men who underwent AUS placement by a single surgeon between September 2009 and June 2017 at our tertiary urban medical center. A uniform perineal approach was used to ensure cuff placement around the most proximal corpus spongiosum after precise spongiosal measurement...
July 14, 2018: BJU International
Firas G Petros, Aradhana M Venkatesan, Diana Kaya, Chaan S Ng, Bryan M Fellman, Jose A Karam, Christopher G Wood, Surena F Matin
OBJECTIVES: To determine conditional survival for patients with small renal masses (SRM) undergoing active surveillance (AS). MATERIALS AND METHODS: Patients were enrolled in a prospective AS protocol at our institution between May 2005 and January 2016. Patients with SRM ≤4cm with serial cross-sectional imaging available in-house for review were included. Overall survival (OS) was estimated using Kaplan-Meier method and modeled via Cox proportional hazards models...
July 14, 2018: BJU International
Wei Shen Tan, Rachael Sarpong, Pramit Khetrapal, Simon Rodney, Hugh Mostafid, Joanne Cresswell, Dawn Watson, Abhay Rane, James Hicks, Giles Hellawell, Melissa Davies, Shalom J Srirangam, Louise Dawson, David Payne, Norman Williams, Chris Brew-Graves, Andrew Feber, John D Kelly
OBJECTIVES: To determine the diagnostic accuracy of urinary cytology to diagnose bladder cancer and upper tract urothelial cancer (UTUC) as well as the outcome of patients with a positive urine cytology and normal haematuria investigations in patients in a multicentre prospective observational study of patients investigated for haematuria. PATIENT AND METHODS: The DETECT I study (clinicaltrials. gov NCT02676180) recruited patients presenting with haematuria following referral to secondary case at 40 hospitals...
July 12, 2018: BJU International
Adam Wiggins, Peter N Tsambarlis, George Abdelsayed, Laurence A Levine
OBJECTIVES: To assess baseline characteristics of a cohort of young men with erectile dysfunction (ED) but no identifiable organic cause and evaluate the efficacy of our treatment algorithm. PATIENTS AND METHODS: We retrospectively reviewed the charts of men under the age of 40 referred to our tertiary care center for evaluation and treatment of their ED between March 2010 and August 2016. Of 185 men reviewed, we included 73 men who were identified as having no identifiable organic cause of their ED and had successfully completed a detailed questionnaire regarding their medical and sexual history at the initial consultation...
July 11, 2018: BJU International
M Vermandere, T Kuijpers, J S Burgers, I Kunnamo, J van Lieshout, E Wallace, J Vlayen, E Schoenfeld, R A Siemieniuk, L Trevena, X Zhu, F Verermen, B Neuschwander, P H Dahm, K A O Tikkinen, K Aubrey-Bassler, R W M Vernooij, B Aertgeerts, G E Bekkering
BACKGROUND: The role of medical expulsive therapy for uncomplicated ureteral stones remains controversial in light of new contradictory trial evidence. A Cochrane review was recently published to summarize the current best evidence on this topic. AIM: To develop an evidence-based recommendation concerning the use of alpha-blockers for uncomplicated ureteral stones, based on an up-to-date Cochrane review. METHOD: We applied the Rapid Recommendations approach to guideline development, which represents an innovative approach by an international collaborative network of clinicians, researchers, methodologists and patient representatives seeking to rapidly respond to new, potentially practice-changing evidence with recommendations developed according to standards for trustworthy guidelines...
July 11, 2018: BJU International
Angela Smith, Siamak Daneshmand, Sanjay Patel, Kamal Pohar, Edouard Trabulsi, Michael Woods, Tracy Downs, Willim Huang, Jeffrey Jones, Michael O'Donnell, Trinity Bivalacqua, Joel DeCastro, Gary Steinberg, Ashish Kamat, Matthew Resnick, Badrinath Konety, Mark Schoenberg, J Stephen Jones, Yair Lotan
PURPOSE: This prospective, multi-center, phase III study evaluated blue light flexible cystoscopy (BLFC) with Hexaminolevulinate (HAL) in office surveillance of patients with non-muscle invasive bladder cancer at high risk of recurrence. We evaluated the impact on pain, anxiety, subjective value of the test, and willingness to pay. MATERIALS AND METHODS: The PROMIS Anxiety, Pain and "Was It Worthwhile" questionnaires were administered at baseline, after surveillance with BLFC, and after resection for those referred to the OR...
July 6, 2018: BJU International
Sahyun Pak, Sejun Park, Myong Kim, Heounjeong Go, Yong Mee Cho, Hanjong Ahn
Intraoperative frozen section (IFS) analysis is a common procedure in general surgical pathology practice. IFS analysis enables identification of the surgical margin status during radical prostatectomy (RP) for prostate cancer. In cases with a positive IFS, further tissue resection is often performed to achieve conversion to a histologically negative margin. However, some advocate that IFS analysis during RP is not justifiable because it has low sensitivity, meaning that a significant proportion of positive margins would be missed with this technique [1, 2]...
July 6, 2018: BJU International
Bhawanie Koonj Beharry, Melinda Craike, Damien Bolton, Patricia M Livingston, Shomik Sengupta
Randomized controlled trials (RCTs) provide the highest quality evidence for clinical practice. The broader applicability of RCT findings assumes that the study participants are representative of the population. However, systematic differences between study participants and non-participants may occur - in part due to stringent inclusion criteria. Recruitment into RCTs can also sometimes be difficult with many clinical trials reporting low recruitment rates for a variety of reasons.[1] The aim of this study was to compare the characteristics of eligible men with prostate cancer who did or did not consent to enroll in the ENGAGE study, a cluster randomized RCT to determine the impact of a clinician referred exercise program...
July 6, 2018: BJU International
R Dhariwal, N Pindoria, P Dasgupta, M S Khan
Bladder cancer is the seventh commonest cancer in the UK and the second leading cause of mortality amongst genitourinary malignancies, representing a significant health burden. In 2011, there was approximately 10,400 new diagnoses of bladder cancer and 5,100 deaths. There has been little progress in 5-year survival rates over the last two decades and hence a desperate need for new therapeutic approaches. The advances in immunotherapy and the introduction of checkpoint inhibitors marks a significant milestone for this disease...
July 4, 2018: BJU International
Felix Cheung, Ali Fathollahi, Emily Vertosick, Thomas R Jarvis, Darren Katz, Jaspreet S Sandhu
OBJECTIVES: To present a modified technique in artificial urinary sphincter (AUS) placement that is associated with low rates of erosion and infection in a high-risk population. MATERIAL AND METHODS: After IRB approval, we identified patients who underwent primary AUS placement using the modified technique between January 2007 and November 2015. Our modification consists of preserving the dorsal fibro-muscular tissue surrounding the bulbar urethra and horizontally transecting the ventral bulbospongiosus muscle during urethral cuff placement...
July 3, 2018: BJU International
Naief Dahran, Magdalena Szewczyk-Bieda, Sarah Vinnicombe, Stewart Fleming, Ghulam Nabi
OBJECTIVES: To investigate relationship between periprostatic adipose tissue (PPAT) adipokines expression and PCa aggressiveness using both pathological features of radical prostatectomy (RP) and multiparametric MRI parameters. PATIENTS AND METHODS: Sixty-nine men were recruited to assess immunohistochemical expression of TNFα- and VEGF of periprostatic fat of radical prostate specimens. Percent immunopositivity was quantified on scanned slides using Aperio Positive Pixel Count algorithm for PPAT TNFα, VEGF and androgen receptors...
July 3, 2018: BJU International
Nathan C Wong, Cameron Lam, Lisa Patterson, Bobby Shayegan
OBJECTIVES: To train and compare machine learning algorithms to traditional regression analysis for the prediction of early biochemical recurrence following robotic prostatectomy. Machine learning allows for the analysis and interpretation of "big data" in a semi-automated and adaptive fashion. Predictive algorithms can arm clinicians with knowledge that can provide personalized medicine to patient care. SUBJECTS AND METHODS: A prospectively collected dataset of 338 patients who underwent robotic prostatectomy for localized prostate cancer was examined...
July 3, 2018: BJU International
Pertti Nurminen, Otto Ettala, Marjo Seppänen, Pekka Taimen, Peter Boström, Antti Kaipia
OBJECTIVES: To investigate the need to biopsy erythematous lesions of bladder after BCG treatment and diagnostic value of voided urine cytology in detection of recurrence. MATERIALS & METHODS: Data on 206 consequent NMIBC patients treated with one or more BCG instillations in 2009-2015 in Satakunta Central Hospital and Turku University Hospital were reviewed. Biopsy histology were pooled according to lesion cystoscopy appearance regarding growth pattern and presence of erythema...
June 29, 2018: BJU International
Tom Stonier, Nick Simson, John Davis, Ben Challacombe
Since robotic-assisted radical prostatectomy (RARP) started to be regularly performed in 2001 the procedure has typically followed the original retropubic approach, with incremental technical improvements in an attempt to improve outcomes. These include the running Van-Velthoven anastomosis, posterior reconstruction or "Rocco stitch" [1], and cold ligation of the Santorini plexus/dorsal vein to maximise urethral length. In 2010 Bocciardi's team in Milan proposed a novel posterior or 'Retzius-sparing' prostatectomy (RS-RARP), mirroring the classic open perineal approach [2]...
June 29, 2018: BJU International
Ugo De Giorgi, Giacomo Cartenì, Diana Giannarelli, Umberto Basso, Luca Galli, Enrico Cortesi, Claudia Caserta, Sandro Pignata, Roberto Sabbatini, Alessandra Bearz, Sebastiano Buti, Giovanni Lo Re, Alfredo Berruti, Sergio Bracarda, Francesco Cognetti, Francesca Rastelli, Giuseppe Fornarini, Camillo Porta, Daniele Turci, Cora N Sternberg, Giuseppe Procopio
OBJECTIVE: To report the safety and efficacy results of patients enrolled in the Italian Nivolumab Renal Cell Cancer Early Access Program. PATIENTS AND METHODS: Patients with metastatic renal cell cancer (mRCC) previously treated with agents targeting the vascular endothelial growth factor pathway were eligible to receive nivolumab 3 mg/kg once every 2 weeks. Patients included in the analysis had received ≥ 1 dose of nivolumab and were monitored for adverse events (AEs) using CTCAE v...
June 29, 2018: BJU International
Paolo Capogrosso, Edoardo Pescatori, Enrico Caraceni, Nicola Mondaini, Lilia Utizi, Tommaso Cai, Andrea Salonia, Alessandro Palmieri, Federico Deho
OBJECTIVES: To investigate scores and predictors of patient's satisfaction at 1-year after penile prosthesis implantation (PPI) using the validated tool called Quality of Life and Sexuality with Penile Prosthesis (QoLSPP). PATIENTS AND METHODS: Analyses were performed for 142 patients prospectively included in the national multicentre registry Italian Nationwide Systematic Inventarisation of Surgical Treatment for Erectile Dysfunction (INSIST-ED) and providing 1-year follow-up data...
June 29, 2018: BJU International
Nelson N Stone, Richard G Stock
To report the long-term results of prostate brachytherapy followed by external beam irradiation (EBRT) in men with a positive seminal vesicle biopsy (+SVB). Materials and Methods 1981 men with localized prostate cancer were treated with permanent brachytherapy of which 615 had staging SVB and 53 (9.4%) were positive. Higher stage, Gleason score and PSA were associated with a positive SVB (p<0.001). Patients with +SVB and negative laparoscopic pelvic lymph node dissection, bone and CT scans had 3 months of androgen deprivation therapy (ADT) followed by Pd-103 implant to the prostate (dose 100 Gy) and proximal SVs and 2 months later 45 Gy EBRT...
June 29, 2018: BJU International
Aram Kim, Min Seo Kim, Young-Jin Park, Woo Suk Choi, Hyoung Keun Park, Sung Hyun Paick, Myung-Soo Choo, Hyeong Gon Kim
OBJECTIVES: To assess and compare the long-term efficacy and safety of single-incision mini-slings (SIMS) except tension-free vaginal tape (TVT)-Secur with standard midurethral slings (SMUS) for female stress urinary incontinence through an updated systematic review and meta-analysis of randomized controlled trials (RCTs) comparing these 2 surgical methods. MATERIALS AND METHODS: A literature review of all RCTs comparing SIMS (Mini-Arc, Contasure-Needleless, Ophira, Tissue Fixation System, and Ajust) except TVT-Secur with SMUS was performed...
June 21, 2018: BJU International
Jemma A Moody, Kamran Ahmed, Tet Yap, Suks Minhas, Majid Shabbir
OBJECTIVES: To determine the impact of testicular cancer and its treatments on fertility and to review the current management options for the infertile, testicular cancer patient, both before diagnosis and after treatment, with the aim to provide practical recommendations to update contemporary guidelines and standardise clinical practice. PATIENTS AND METHODS: Searches for relevant articles on Pubmed and Google Scholar between 2000-2017, with additional articles sourced from reference lists of included publications...
June 19, 2018: BJU International
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