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BJU International

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https://www.readbyqxmd.com/read/28220653/systematic-review-of-the-oncological-and-functional-outcomes-of-pelvic-organ-preserving-cystectomy-compared-with-standard-radical-cystectomy-in-women-who-undergo-curative-surgery-and-orthotopic-neobladder-substitution-for-bladder-cancer
#1
REVIEW
Erik Veskimäe, Yann Neuzillet, Mathieu Rouanne, Steven MacLennan, Thomas B L Lam, Yuhong Yuan, Eva Compérat, Nigel C Cowan, Georgios Gakis, Antoine G van der Heijden, Maria J Ribal, J Alfred Witjes, Thierry Lebrét
CONTEXT: Pelvic-organ preserving radical cystectomy (POPRC) for female patients may improve postoperative sexual and urinary functions without compromising the oncological outcome compared with standard radical cystectomy (RC). OBJECTIVE: To determine the effect of POPRC on sexual, oncological and urinary outcomes compared with RC in women who undergo standard curative surgery and orthotopic neobladder substitution for bladder cancer (BCa). EVIDENCE ACQUISITION: Medline, Embase, Cochrane controlled trials databases and clinicaltrial...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28220652/etiology-and-management-of-earlier-versus-later-biochemical-recurrence-following-retropubic-radical-prostatectomy
#2
Elton Llukani, Herbert Lepor
Approximately 100,000 radical prostatectomies (RP) are performed annually in the US with the intent to cure clinically localized prostate cancer. Oncological control following RP is assessed by monitoring serum PSA levels. By consensus, a PSA exceeding 0.2 ng/mL is considered the threshold for a biochemical recurrence (BCR) following RP (3). BCR often predates radiographic and clinical evidence of disease recurrence by many years (4-6). This article is protected by copyright. All rights reserved.
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28220605/outcome-predictors-of-radical-cystectomy-in-patients-with-ct4-prostate-cancer-a-multi-institutional-study-of-62-patients
#3
Martin Spahn, Alessandro Morlacco, Silvan Boxler, Steven Joniau, Alberto Briganti, Francesco Montorsi, Paolo Gontero, Pia Bader, Detlef Frohneberg, Hein van Poppel, R Jeffrey Karnes
OBJECTIVES: To identify which patients with macroscopic bladder infiltrating T4 prostate cancer (PCa) might have favorable outcomes when treated with radical cystectomy (RC) MATERIALS AND METHODS: We evaluated 62 patients with cT4cN0-1cM0 PCa treated with RC and pelvic lymph node dissection between 1972-2011. In addition to descriptive statistics, the Kaplan-Meier method and log-rank tests were used to depict survival rates. Uni- and multivariate Cox regression analysis tested the association between predictors and progression-free, PCa-specific-, and overall survival...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28220601/multiple-sclerosis-and-nephrolithiasis-a-matched-case-comparative-study
#4
Vishnu Ganesan, Wen Min Chen, Rajat Jain, Shubha De, Manoj Monga
OBJECTIVE: To compare stone composition and serum/urine biochemistries in stone formers with multiple sclerosis (MS) against stone formers without MS and to examine the association between mobility, methods of bladder emptying, and stone formation. MATERIALS AND METHODS: In this retrospective case-control study, we identified patients diagnosed with multiple sclerosis and kidney stone disease who were seen at our institution between 2001 and 2016. For the first part of the study, up to 2 controls (stone formers without a history of MS) were identified for each case and matched on age, body mass index (BMI), and sex...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28220593/robot-assisted-approach-to-w-configuration-urinary-diversion-a-step-by-step-technique
#5
Ahmed A Hussein, Youssef E Ahmed, Justen D Kozlowski, Paul May, John Nyquist, Sandra Sexton, Leslie Curtin, James O Peabody, Hassan Abol-Enein, Khurshid A Guru
INTRODUCTION: To describe a detailed step-by-step approach of our technique to robot-assisted intracorporeal "W" orthotopic ileal neobladder (ICNB). METHODS: Five patients underwent robot-assisted radical cystectomy (RARC), extended pelvic lymph node dissection (ePLND) and ICNB. ICNB was divided into 6 key steps to facilitate and enable a detailed analysis and auditing of the technique. No conversion to open surgery was required. Timing for each step was noted. All patients had at least 3 months of follow up...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28220589/pcnl-access-by-urologist-or-interventional-radiologist-practice-and-outcomes-in-the-united-kingdom
#6
James N Armitage, John Withington, Sarah Fowler, William Jg Finch, Neil A Burgess, Stuart O Irving, Jonathan Glass, Oliver J Wiseman
INTRODUCTION AND OBJECTIVE: Obtaining percutaneous access to the renal collecting system is fundamental to safe and effective percutaneous nephrolithotomy (PCNL). Practice varies between countries, hospitals and individual surgeons as to whether access is obtained by a urologist or an interventional radiologist (IR). We compared outcomes of urologist versus IR tracts in the contemporary UK setting. PATIENTS AND METHODS: Data submitted to the British Association of Urological Surgeons (BAUS) PCNL data registry between 2009 and 2015 were analysed according to whether access was obtained by a urologist or an IR...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28220583/morphometric-analysis-of-prostate-zonal-anatomy-using-magnetic-resonance-imaging-mri-the-impact-on-age-related-changes-in-japanese-and-american-populations
#7
Toru Matsugasumi, Atsuko Fujihara, So Ushijima, Motohiro Kanazawa, Yasuhiro Yamada, Takumi Shiraishi, Fumiya Hongo, Kazumi Kamoi, Koji Okihara, Andre Luis de Castro Abreu, Masakatsu Oishi, Toshitaka Shin, Suzanne Palmer, Inderbir S Gill, Osamu Ukimura
OBJECTIVES: Magnetic resonance imaging (MRI) can be used to reliably evaluate prostate zonal anatomy. Objectives of this study was to evaluate the impact of morphometric MRI analysis of the prostate zonal anatomy on aging, prostatic hypertrophy, and lower urinary tract symptoms in patients from Japan and the USA. SUBJECTS AND METHODS: A retrospective analysis of 307 men, including Japanese (n=156) and American (n=151) patients, who consecutively underwent 3-Tesla MRI and International Prostate Symptom Score (IPSS) due to elevated PSA...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28220579/long-term-results-of-ileal-ureteric-replacement-a-25-years-single-centre-experience
#8
Arkadius Kocot, Charis Kalogirou, Daniel Vergho, Hubertus Riedmiller
OBJECTIVES: To report the long-term outcome of ileal ureteric replacement (IUR) in complex reconstruction of the urinary tract. PATIENTS AND METHODS: From 1991 to 2016, IUR was performed in 157 patients with structural or functional ureteric loss. In 52 patients, bilateral IUR became necessary. Implantation sites where either the native urinary bladder (n=79) or intestinal reservoirs (n=78). In the latter group, the technique was used at the time of primary urinary diversion (n=34), in a secondary approach (n=29) and in undiversion or conversion procedures (n=15)...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28207981/a-multiparametric-magnetic-resonance-imaging-based-risk-model-to-determine-the-risk-of-significant-prostate-cancer-prior-to-biopsy
#9
Pim J van Leeuwen, Andrew Hayen, James E Thompson, Daniel Moses, Ron Shnier, Maret Böhm, Magdaline Abuodha, Anne-Maree Haynes, Francis Ting, Jelle Barentsz, Monique Roobol, Justin Vass, Krishan Rasiah, Warick Delprado, Phillip D Stricker
OBJECTIVES: To develop and externally validate a predictive model for detection of significant prostate cancer (PC). SUBJECTS AND METHODS: Development of the model was based on prospective cohort including 393 men who underwent mpMRI prior to biopsy. External validity of the model was then examined retrospectively in 198 men from a separate institution whom underwent a mpMRI followed by biopsy for abnormal PSA/DRE. A model was developed with age, PSA, DRE, prostate volume, previous biopsy and PIRADS score as predictors for significant PC (Gleason 7 with >5% grade 4, ≥ 20% cores positive or ≥ 7mm of PC in any core)...
February 16, 2017: BJU International
https://www.readbyqxmd.com/read/28199761/calculating-life-expectancy-to-inform-prostate-cancer-screening-and-treatment-decisions
#10
LETTER
Scott R Hawken, Gregory B Auffenberg, David C Miller, Brian R Lane, Michael L Cher, Firas Abdollah, Hyunsoon Cho, Khurshid R Ghani
Current guidelines for prostate cancer (PCa) consider life expectancy (LE) an important factor when making screening and treatment decisions. For patients with LE<10 years, most guidelines recommend against PCa screening and active surveillance or definitive treatment of low risk disease.(1,2) Nevertheless, recent work has demonstrated that men with limited LE often undergo PSA screening and biopsy for PCa.(3,4) With an increasing emphasis on guideline-directed management, pragmatic tools for point-of-care 10-year LE estimates are needed to inform these clinical decisions...
February 15, 2017: BJU International
https://www.readbyqxmd.com/read/28192632/assessing-the-relative-influence-of-hospital-and-surgeon-volume-on-short-term-mortality-following-radical-cystectomy
#11
Nikhil Waingankar, Katherine Mallin, Marc Smaldone, Brian L Egleston, Andrew Higgins, David P Winchester, Robert Uzzo, Alexander Kutikov
OBJECTIVES: To assess the relationship between surgeon and hospital volume on mortality following radical cystectomy (RC). PATIENTS AND METHODS: We queried the National Cancer Database (NCDB) for adult patients undergoing RC from 2010-2013. We calculated average volume for each surgeon (SV) and hospital (HV). Using propensity-scored weights for combined volume groups with a proportional hazards regression model, we compared association between HV and SV on 90-day survival following RC...
February 13, 2017: BJU International
https://www.readbyqxmd.com/read/28188689/sentinel-node-biopsy-for-prostate-cancer-report-from-a-consensus-panel-meeting
#12
Henk G van der Poel, Esther M Wit, Cenk Acar, Nynke S van den Berg, Fijs W B van Leeuwen, Renato A Valdes Olmos, Alexander Winter, Friedhelm Wawroschek, Fredrik Liedberg, Steven Maclennan, Thomas Lam
OBJECTIVE: To explore the evidence and knowledge gaps in sentinel node biopsy (SNB) in prostate cancer by a consensus panel of experts. METHODS: A two-round Delphi survey among experts was followed by a consensus panel meeting of 16 experts in February 2016. Agreement voting was performed using the RAND/University of California, Los Angeles Appropriateness Methodology on 150 statements in 9 domains. The disagreement index based on the interpercentile range-adjusted for symmetry score was used to assess consensus and non-consensus among panel members RESULTS: Consensus was obtained on 91 of 150 (61%) statements...
February 10, 2017: BJU International
https://www.readbyqxmd.com/read/28188682/stereotactic-ablative-body-radiotherapy-for-inoperable-primary-kidney-cancer-a-prospective-clinical-trial
#13
Shankar Siva, Daniel Pham, Tomas Kron, Mathias Bressel, Jacqueline Lam, Tan Teng Han, Brent Chesson, Mark Shaw, Sarat Chander, Suki Gill, Nicholas R Brook, Nathan Lawrentschuck, Declan G Murphy, Farshad Foroudi
OBJECTIVE: To assess the feasibility and safety of stereotactic ablative body radiotherapy (SABR) for RCC in patients unsuitable for surgery. Secondary objectives were to assess oncologic and functional outcomes. MATERIALS AND METHODS: This was a prospective interventional clinical trial with institutional ethics board approval. Inoperable patients were enrolled after multidisciplinary consensus for intervention and informed consent. Tumor response was defined using RECIST 1...
February 10, 2017: BJU International
https://www.readbyqxmd.com/read/28182321/detection-and-oncological-effect-of-circulating-tumour-cells-in-patients-with-variant-urothelial-carcinoma-histology-treated-with-radical-cystectomy
#14
Armin Soave, Sabine Riethdorf, Roland Dahlem, Sarah Minner, Lars Weisbach, Oliver Engel, Margit Fisch, Klaus Pantel, Michael Rink
OBJECTIVES: To investigate for the presence of circulating tumour cells (CTC) in patients with variant urothelial carcinoma of the bladder (UCB) histology treated with radical cystectomy (RC), and to determine their impact on oncological outcomes. PATIENTS AND METHODS: We prospectively collected data of 188 patients with UCB treated with RC without neoadjuvant chemotherapy. Pathological specimens were meticulously reviewed for pure and variant UCB histology. Preoperatively collected blood samples (7...
February 9, 2017: BJU International
https://www.readbyqxmd.com/read/28181381/changes-in-penile-length-after-radical-prostatectomy-investigation-of-the-underlying-anatomical-mechanism
#15
Yoshifumi Kadono, Kazuaki Machioka, Kazufumi Nakashima, Masashi Iijima, Kazuyoshi Shigehara, Takahiro Nohara, Kazutaka Narimoto, Kouji Izumi, Yasuhide Kitagawa, Hiroyuki Konaka, Toshifumi Gabata, Atsushi Mizokami
OBJECTIVE: To measure changes in penile length (PL) over time before and after radical prostatectomy (RP), and to investigate the underlying mechanisms for these changes. PATIENTS AND METHODS: The stretched PL (SPL) of 102 patients was measured before, 10 days after, and at 1, 3, 6, 9, 12, 18 and 24 months after RP. The perpendicular distance from the distal end of the membranous urethra to the midline of the pelvic outlet was measured on mid-sagittal magnetic resonance imaging (MRI) slice at three time points: preoperatively; 10 days after RP; and 12 months after RP...
February 8, 2017: BJU International
https://www.readbyqxmd.com/read/28170154/novel-use-of-twitter-to-disseminate-and-evaluate-adherence-with-clinical-guidelines-by-the-european-association-of-urology
#16
LETTER
Stacy Loeb, Morgan Roupret, Inge Van Oort, James N'dow, Marc Van Gurp, Jarka Bloemberg, Julie A Darraugh, Maria Ribal
The European Association of Urology was the first scientific association to systematically convert the clinical guidelines into social media posts for dissemination through twitter. Posts were classified using the hashtag #eauguidelines and each post was <140 characters which is the limit for twitter. The goals of this project were to increase dissemination of the guidelines, and to test adherence with guidelines recommendations through a series of twitter based-polls. During the first 18 months of this project (January 2015 - June 2016), there were 8,709 posts about the guidelines, with a total reach of 9,117,746 impressions...
February 7, 2017: BJU International
https://www.readbyqxmd.com/read/28145037/ureteric-stent-dwelling-time-a-risk-factor-for-post-ureteroscopy-sepsis
#17
Amihay Nevo, Roy Mano, Jack Baniel, David A Lifshitz
OBJECTIVES: To evaluate the association between stent dwelling time and sepsis after ureteroscopy, and identify risk factors for sepsis in this setting. PATIENTS AND METHODS: The prospectively collected database of a single institution was queried for all patients who underwent ureteroscopy for stone extraction between 2010 and 2016. Demographic, clinical, preoperative and operative data were collected. The primary study endpoint was sepsis within 48 h of ureteroscopy...
February 1, 2017: BJU International
https://www.readbyqxmd.com/read/28139068/positive-outcomes-with-first-onabotulinumtoxina-treatment-persist-long-term-with-repeat-treatments-in-patients-with-neurogenic-detrusor-overactivity
#18
Pierre Denys, Roger Dmochowski, Philip Aliotta, David Castro-Diaz, Bertil Blok, Karen Ethans, Tamer Aboushwareb, Andrew Magyar, Michael Kennelly
OBJECTIVE: To examine whether response to first treatment with onabotulinumtoxinA is predictive of long-term treatment outcome in neurogenic detrusor overactivity (NDO) patients. PATIENTS AND METHODS: NDO patients in a 3-year extension study (following a 52-week phase 3 study) received onabotulinumtoxinA 'as needed' based on fulfilment of prespecified retreatment criteria. This post-hoc analysis included patients who received only the 200U dose during the phase 3 and extension studies...
January 31, 2017: BJU International
https://www.readbyqxmd.com/read/28139034/prostate-cancer-screening-practices-in-a-large-integrated-health-system-2007-2014
#19
Anita D Misra-Hebert, Bo Hu, Eric A Klein, Andrew Stephenson, Glen B Taksler, Michael W Kattan, Michael B Rothberg
OBJECTIVES: To assess prostate cancer (PCa) screening practices in primary care since the initial United States Preventive Services Task Force (USPSTF) recommendation against prostate specific antigen (PSA) testing for older men, and to assess primary provider variation associated with PCa screening. PATIENTS AND METHODS: Our study population included 160, 211 men age >= 40 with at least 1 visit in a primary care clinic in any of the study years in a large, integrated health system...
January 31, 2017: BJU International
https://www.readbyqxmd.com/read/28139024/anatomic-patterns-of-recurrence-following-biochemical-relapse-after-post-prostatectomy-salvage-radiation-therapy-a-multi-institutional-study
#20
William C Jackson, Neil Desai, Ahmed E Abugharib, Vasu Tumati, Robert T Dess, Jae Y Lee, Shuang G Zhao, Moaaz Soliman, Michael Folkert, Aaron Laine, Raquibul Hannan, Zachary S Zumsteg, Howard Sandler, Daniel A Hamstra, Jeffrey S Montgomery, David C Miller, Mike A Kozminski, Brent K Hollenbeck, Jason W Hearn, Ganesh Palapattu, Scott A Tomlins, Rohit Mehra, Todd M Morgan, Felix Y Feng, Daniel E Spratt
OBJECTIVES: To characterize the frequency and detailed anatomic sites of failure for patients receiving post-radical prostatectomy (RP) salvage radiation therapy (SRT). MATERIALS/METHODS: A multi-institutional retrospective study was performed on 574 men who underwent SRT between 1986 and 2013. Anatomical recurrence patterns were classified as lymphotropic (lymph nodes only), osteotropic (bone only), or multifocal if both were present. Isolated first failure sites were defined as sites of initial clinically detected recurrence that remained isolated for at least 3 months...
January 31, 2017: BJU International
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