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BJU International

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https://www.readbyqxmd.com/read/29140596/florence-robotic-intracorporeal-neobladder-florin-a-new-reconfiguration-strategy-developed-following-the-ideal-guidelines
#1
Andrea Minervini, Davide Vanacore, Gianni Vittori, Martina Milanesi, Agostino Tuccio, Giampaolo Siena, Riccardo Campi, Andrea Mari, Andrea Gavazzi, Marco Carini
OBJECTIVE: To describe our step-by-step technique for robotic intracorporeal neobladder configuration, including the stages of conception, development and exploration of this surgical innovation, according to the IDEAL Collaboration guidelines. PATIENTS AND METHODS: FloRIN neobladder was performed after the following main surgical steps: isolation of 50 cm of ileum; bowel anastomosis; urethro-ileal anastomosis creating an asymmetrical U shape (30 cm distally and 20 cm proximally to anastomosis), ileum detubularisation; posterior wall reconfiguration as an L; bladder neck reconstruction; anterior folding of the posterior plate to reach the 12 o'clock position; uretero-enteral "orthotopic" bilateral anastomosis...
November 15, 2017: BJU International
https://www.readbyqxmd.com/read/29124911/first-north-american-validation-and-head-to-head-comparison-of-four-preoperative-nomograms-for-prediction-of-lymph-node-invasion-before-radical-prostatectomy
#2
Marco Bandini, Michele Marchioni, Raisa S Pompe, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Firas Abdollah, Markus Graefen, Francesco Montorsi, Fred Saad, Shahrokh F Shariat, Alberto Briganti, Pierre I Karakiewicz
OBJECTIVES: To perform a head-to-head comparison of four nomograms, namely the Cagiannos, the 2012-Briganti, the Godoy and the online-Memorial Sloan Kettering Cancer Center (MSKCC), for prediction of lymph node invasion (LNI) in a North American population. MATERIALS & METHODS: 19,775 clinically localized prostate cancer (PCa) patients underwent radical prostatectomy and pelvic lymph node dissection (PLND) were identified within the Surveillance Epidemiology and End Results (SEER) database...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29124889/the-neurosafe-approach-to-nerve-sparing-in-robotic-assisted-radical-prostatectomy-in-a-british-setting-a-prospective-observational-comparative-study
#3
George Mirmilstein, Bhavan Rai, Olayinka Gbolahan, Vinaya Srirangam, Ashish Narula, Samita Agarwal, Tim Lane, Nikhil Vasdev, Jim Adshead
OBJECTIVES: To evaluate the NeuroSAFE technique in a British setting in men undergoing RALP. PATIENTS AND METHODS: We retrospectively analysed our prospectively maintained database of patients who underwent RALP between Nov 2008 and Feb 2017. We examined preoperative pathological and functional parameters, intra-operative nerve sparing, post-operative histology as well as functional and oncological follow-up. We compared those who had a NeuroSAFE approach and those who had nerve sparing without NeuroSAFE...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29124881/the-implications-of-baseline-bone-health-assessment-at-initiation-of-androgen-deprivation-therapy-for-prostate-cancer
#4
Peter S Kirk, Tudor Borza, Vahakn B Shahinian, Megan E V Caram, Danil V Makarov, Jeremy B Shelton, John T Leppert, Ryan M Blake, Jennifer A Davis, Brent K Hollenbeck, Anne Sales, Ted A Skolarus
OBJECTIVES: To assess bone density testing (BDT) use among prostate cancer survivors receiving ADT, and downstream implications for osteoporosis and fracture diagnoses as well as pharmacologic osteoporosis treatment in a national integrated delivery system. METHODS: We identified 17,017 men with prostate cancer who received any ADT between 2005 and 2014 using Veterans Health Administration cancer registry and administrative data. We identified claims for BDT within a 3-year period of ADT initiation...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29124877/sporadic-primary-hyperparathyroidism-and-stone-disease-a-comprehensive-metabolic-evaluation-before-and-after-parathyroidectomy
#5
Giovanni S Marchini, Kauy V M Faria, Fábio C M Torricelli, Manoj Monga, Miguel Srougi, William C Nahas, Eduardo Mazzucchi
OBJECTIVES: to characterize the stone risk and the impact of parathyroidectomy on the metabolic profile of patients with primary hyperparathyroidism (PHPT) and urolithiasis. SUBJECTS AND METHODS: We analyzed the prospectively collected charts of patients treated at our stone clinic from Jan/2001-Jan/2016 searching for patients with PHPT and urolithiasis. Imaging evaluation of the kidneys, bones and parathyroid glands were assessed. We analyzed the demographic data, serum and urinary parameters before and after parathyroidectomy...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29124870/defining-a-hba1c-value-that-predicts-increased-risk-of-penile-implant-infection
#6
Mohamad Habous, Raanan Tal, Tarek Soliman, Alaa Tealab, Mohammed Nassar, Zenhom Mekawi, Saad Mahmoud, Osama Abdelwahab, Mohamed Elkhouly, Hatem Kamr, Abdallah Remeah, Saleh Binsaleh, David Ralph, John Mulhall
OBJECTIVES: To explore the association between HbA1C level and penile implant infection rates and to define a cut-off value that predicted implant infection. PATIENTS AND METHODS: A multi center prospective study included all patients undergoing penile implant surgery between 2009-15. Preoperative, perioperative and postoperative management were identical for the entire cohort. Univariate analysis was performed to define predictors of implant infection. HbA1c levels were analyzed as a continuous variable and sequential analysis was conducted utilizing 0...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29124853/intracorporeal-robotic-assisted-radical-cystectomy-together-with-an-enhanced-recovery-programme-improves-postoperative-outcomes-by-aggregating-marginal-gains
#7
Wei Shen Tan, Mae-Yen Tan, Benjamin W Lamb, Ashwin Sridhar, Anna Mohammed, Hilary Baker, Senthil Nathan, Timothy Briggs, Melanie Tan, John D Kelly
OBJECTIVE: To assess the cumulative effect of an enhanced recovery after surgery (ERAS) pathway and a minimally invasive RARC with intracorporeal urinary diversion (iRARC) in comparison to open radical cystectomy (ORC) on hospital length of stay (LOS) and perioperative outcomes. MATERIALS & METHODS: Between Feb 2009 and Oct 2017, 304 radical cystectomy cases were performed at a single institution (54 ORC, 250 RARC). Data were prospectively collected. We identified 45 consecutive ORC cases performed without ERAS before the commencement of the RARC programme (Cohort A), 50 consecutive iRARC cases performed without ERAS (Cohort B) and 40 iRARC cases with ERAS (Cohort C)...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29105258/surgical-management-of-azoospermia-can-the-nhs-england-clinical-commissioning-policy-reduce-geographical-inequality-of-services
#8
LETTER
Majid Shabbir, Chitranjan J Shukla, Gareth Brown, Trevor John Dorkin, Marc Lucky, Richard Pearcy, Rowland Rees, Duncan Summerton, Asif Muneer
Developments in assisted reproductive techniques (ART) have transformed the management of male factor infertility and the advent of intracytoplasmic sperm injection (ICSI) in 1993 was a landmark in the management of the infertile male. While this has been an undoubted success, it has led to a shift away from understanding and correcting the potential reversible causes of male factor infertility, to one that simply overcomes it with assisted reproductive techniques (ART). The aetiology of male infertility can broadly be divided into impaired spermatogenesis, or impaired sperm transport within the genital tract...
November 3, 2017: BJU International
https://www.readbyqxmd.com/read/29072817/the-impact-of-the-global-bcg-shortage-on-treatment-patterns-population-based-data
#9
LETTER
Marlon Perera, Nathan Papa, Daniel Christidis, Shannon McGrath, Todd Manning, Matthew Roberts, Damien Bolton, Nathan Lawrentschuk, Shomik Sengupta
An international shortage of Intravesical Bacillus Calmette-Guérin (BCG) therapy has considerably affected clinical practice patterns for non-muscle invasive bladder cancer. We aimed to review the trends of BCG therapy in Australia between April 2006 and 2016 using Pharmaceutical Benefits Australia data. A sudden, global drop in October/November 2014 and a precipitous fall for the CIS indication in June/July 2012 was identified. After restoration of supply, BCG prescriptions for primary and relapsing TCC rebounded to a higher level than prior to the first shock...
October 26, 2017: BJU International
https://www.readbyqxmd.com/read/29072806/strategies-for-success-a-multi-institutional-study-on-robotic-partial-nephrectomy-for-complex-renal-lesions
#10
D B Hennessey, G Wei, D Moon, N Kinnear, D M Bolton, N Lawrentschuk, Y K Chan
OBJECTIVE: Due to their size, location and proximity to the hilum, some complex renal tumours may preclude a minimally invasive approach to nephron sparing surgery. We describe our technique, illustrated with images and videos, of robotic partial nephrectomy for challenging renal tumours. PATIENTS AND METHODS: A study of 249 patients who underwent robotic partial nephrectomy (RPN) in multiple institutions was performed. Patients were identified using prospective RPN databases...
October 26, 2017: BJU International
https://www.readbyqxmd.com/read/29063734/identifying-the-candidate-for-super-extended-staging-pelvic-lymph-node-dissection-among-patients-with-high-risk-prostate-cancer
#11
Giorgio Gandaglia, Emanuele Zaffuto, Nicola Fossati, Marco Bandini, Nazareno Suardi, Elio Mazzone, Paolo Dell'Oglio, Armando Stabile, Massimo Freschi, Francesco Montorsi, Alberto Briganti
OBJECTIVES: To assess if the preoperative lymph node invasion (LNI) risk could be used to tailor the extent of pelvic lymph node dissection (PLND) according to individual profile in prostate cancer (PCa) patients undergoing radical prostatectomy (RP) and to identify those who would benefit from the removal of the common iliac and presacral nodes. PATIENTS AND METHODS: 471 high-risk PCa patients treated with RP and a super-extended PLND that included the removal of the pre-sacral and common iliac nodes between 2006 and 2016 were identified...
October 24, 2017: BJU International
https://www.readbyqxmd.com/read/29063728/laparoscopic-and-robotic-assisted-versus-open-radical-prostatectomy-for-the-treatment-of-localised-prostate-cancer-a-cochrane-systematic-review
#12
Dragan Ilic, Sue M Evans, Christie Ann Allan, Jae Hung Jung, Declan Murphy, Mark Frydenberg
To determine the effects of laparoscopic radical prostatectomy (LRP), or robotic-assisted radical prostatectomy (RARP), compared to open radical prostatectomy (ORP) in men with localised prostate cancer. We performed a comprehensive search using multiple databases (CENTRAL, MEDLINE, EMBASE) and abstract proceedings with no restrictions on the language of publication or publication status, up until 9 June 2017. We included all randomised or pseudo-randomised controlled trials with a direct comparison of LRP and RARP to ORP...
October 24, 2017: BJU International
https://www.readbyqxmd.com/read/29063725/associations-of-specific-postoperative-complications-with-costs-after-radical-cystectomy
#13
Matthew Mossanen, Ross E Krasnow, Stuart R Lipsitz, Mark A Preston, Adam S Kibel, Albert Ha, John L Gore, Angela B Smith, Jeffrey J Leow, Quoc D Trinh, Steven L Chang
BACKGROUND: Radical cystectomy (RC) is a morbid surgery plagued by complications. Expenditures attributed to specific complications after RC is not well characterized. We sought to quantify the financial impact of complications after RC and their associations with respective 90-day costs. METHODS: We used the Premier Hospital Database to identify 9,137 RC patients (weighted population of 57,553) from 360 hospitals between 2003-2013. Complications were categorized according to Agency for Healthcare Research and Quality Clinical Classifications...
October 24, 2017: BJU International
https://www.readbyqxmd.com/read/29063682/early-discharge-and-post-discharge-outcomes-in-patients-undergoing-radical-cystectomy-for-bladder-cancer
#14
Leilei Xia, Benjamin L Taylor, Andrew D Newton, Aseem Malhotra, Jose E Pulido, Marshall C Strother, Thomas J Guzzo
OBJECTIVE: To assess whether discharging patients early after radical cystectomy (RC) is associated with increased risk of readmissions and post-discharge complications. MATERIALS AND METHODS: The National Surgical Quality Improvement Program (NSQIP) database was queried to identify patients who underwent an elective RC from 2012 to 2015. Patients were stratified into two groups: those with hospital length of stay (LOS) of 4-5 days (early-discharge) and those with LOS of 6-9 days (routine-discharge)...
October 24, 2017: BJU International
https://www.readbyqxmd.com/read/29063681/oxidative-stress-and-its-possible-relation-to-lower-urinary-tract-functional-pathology
#15
REVIEW
K-E Andersson
Oxidative stress is considered to reflect an imbalance between the systemic manifestation of reactive oxygen and nitrogen species (RONS) and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. RONS are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. They are normally generated as by-products of oxygen metabolism; however, environmental stressors (i...
October 24, 2017: BJU International
https://www.readbyqxmd.com/read/29044968/a-prospective-randomised-placebo-controlled-study-of-the-impact-of-dutasteride-tamsulosin-combination-therapy-on-sexual-function-domains-in-sexually-active-men-with-lower-urinary-tract-symptoms-luts-secondary-to-benign-prostatic-hyperplasia-bph
#16
Claus G Roehrborn, Michael J Manyak, Juan Manuel Palacios-Moreno, Timothy H Wilson, Erik Pm Roos, Javier Cambronero Santos, Dimitrios Karanastasis, Janet Plastino, Francois Giuliano, Raymond C Rosen
OBJECTIVE: To prospectively assess the impact of the fixed-dose combination of the 5-alpha reductase inhibitor (5ARI), dutasteride 0.5 mg and the alpha-1 blocker, tamsulosin 0.4 mg (DUT-TAM FDC) therapy on sexual function domain scores in sexually active males with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH), using the Men's Sexual Health Questionnaire (MSHQ). PATIENTS AND METHODS: This European and Australian double-blind, placebo-controlled, parallel-group study was conducted at 51 centres...
October 16, 2017: BJU International
https://www.readbyqxmd.com/read/29032582/national-cohort-study-comparing-severe-medium-term-urinary-complications-following-radical-prostatectomy-robot-assisted-versus-laparoscopic-versus-retropubic-open-radical-prostatectomy
#17
A Sujenthiran, J Nossiter, M Parry, S C Charman, A Aggarwal, H Payne, P Dasgupta, N W Clarke, J van der Meulen, P Cathcart
OBJECTIVES: Despite the rapid adoption of robot-assisted radical prostatectomy (RARP), there is little evidence about the occurrence of medium-term urinary complications with this type of surgery compared to laparoscopic (LRP) or retropubic open radical prostatectomy (ORP). The aim of this study was to evaluate the occurrence of severe urinary complications within two years of surgery in men undergoing RARP, LRP or ORP. PATIENTS AND METHODS: Population-based cohort study of men who underwent RARP (n=4,947), LRP (n= 5,479), or ORP (n=6,873) between 2008 and 2012 in the English National Health Service (NHS) using national cancer registry records linked to Hospital Episodes Statistics - an administrative database of admissions to NHS hospitals...
October 15, 2017: BJU International
https://www.readbyqxmd.com/read/29032581/utilization-and-quality-outcomes-of-ct1a-ct1b-and-ct2a-partial-nephrectomy-analysis-of-the-national-cancer-database
#18
Katherine Fero, Zachary A Hamilton, Ahmet Bindayi, James D Murphy, Ithaar H Derweesh
OBJECTIVE: To describe utilization and compare quality outcomes of partial nephrectomy (PN) for cT1a, cT1b and cT2a renal mass using a large national database. METHODS: Retrospective analysis of patients from the US National Cancer Database who underwent PN for cT1a/cT1b/T2a renal cell carcinoma between 2004-2013. We examined utilization of PN over time and quality indicators [positive surgical margin (PSM) and 30-day postoperative readmission rates (30Day-Readmit)]...
October 15, 2017: BJU International
https://www.readbyqxmd.com/read/29032580/impact-of-ureteroscopy-before-radical-nephroureterectomy-for-upper-tract-urothelial-carcinomas-on-oncological-outcomes-a-meta-analysis
#19
Run-Qi Guo, Peng Hong, Geng-Yan Xiong, Lei Zhang, Dong Fang, Xue-Song Li, Kai Zhang, Li-Qun Zhou
OBJECTIVES: To investigate whether ureteroscopy (URS) before radical nephroureterectomy (RNU) for upper tract urothelial carcinomas (UTUCs) has an impact on oncological outcomes. PATIENTS AND METHODS: We performed a systematic literature search of PubMed, Web of Science, and EMBASE for citations published prior to September 2017 that described URS performed on patients with UTUC and conducted a standard meta-analysis on survival outcomes. RESULTS: Our meta-analysis included eight eligible studies containing 3975 patients...
October 15, 2017: BJU International
https://www.readbyqxmd.com/read/29032579/incidentally-detected-testicular-lesions-10-mm-in-diameter-can-orchidectomy-be-avoided
#20
Glenda Scandura, Clare Verrill, Andrew Protheroe, Johnson Joseph, Wendy Ansell, Anju Sahdev, Jonathan Shamash, Daniel M Berney
OBJECTIVE: To investigate the pathology of excised testicular lesions <10 mm. PATIENTS AND METHODS: The pathological reports of 2,681 patients from Barts Health NHS Trust and Oxford University Hospitals NHS Foundation Trust (OUHFT) were reviewed as part of a service evaluation audit from January 2003 to May 2016. Cases with a maximum diameter of <10 mm were selected. Clinical features were also accessed, where available, to look for patient demographics, pre-diagnostic levels of serum markers, ultrasonograophic (US) findings and clinical details...
October 15, 2017: BJU International
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