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BJU International

Kelly Aubertin, Vincent Quoc Trinh, Michael Jermyn, Paul Baksic, Andrée-Anne Grosset, Joannie Desroches, Karl St-Arnaud, Mirela Birlea, Maria Claudia Vladoiu, Mathieu Latour, Roula Albadine, Fred Saad, Frédéric Leblond, Dominique Trudel
OBJECTIVE: To test if Raman spectroscopy is an appropriate tool for the diagnosis and possibly the grading of prostate cancer. PATIENTS & METHODS: Between 20 and 50 Raman spectra were acquired on 32 fresh and non-processed post-prostatectomy specimens using a macroscopic hand-held Raman spectroscopy probe. Each measured area was characterized and categorized following histopathological criterions like tissue type (extra-prostatic or prostatic), tissue malignancy (benign or malignant), cancer grade (Grade Groups (GG) 1-5), and tissue glandular level...
March 15, 2018: BJU International
Giorgio Ivan Russo, Simone Bier, Jörg Hennenlotter, Gunthild Beger, Lucretia Pavlenco, Jens van de Flierdt, Siegfried Hauch, Moritz Maas, Simon Walz, Steffen Rausch, Jens Bedke, Giuseppe Morgia, Arnulf Stenzl, Tilman Todenhöfer
OBJECTIVE: To evaluate the presence of circulating tumour cells (CTC) at different stages of prostate cancer (PC) using the ProstateCancerDetect kit. Moreover, we aimed to assess the expression of transcripts that are specific for cancer stem cells (AdnaTest StemCell) and epithelial mesenchymal transition (EMT) in CTC (AdnaTest EMT) as well as additional genes that are known to promote PC progression. PATIENTS AND METHODS: In this prospective study, we included 81 patients who underwent treatment for PC between 07/2014 and 02/2015, including A) 18 patients (22...
March 15, 2018: BJU International
Cosimo De Nunzio, Riccardo Lombardo, Antonio Nacchia, Giorgia Tema, Andrea Tubaro
OBJECTIVES: To analyse the impact of repeating PSA levels on prostate biopsy decision in a cohort of men undergoing prostate biopsy. MATERIALS AND METHODS: From 2015 onwards, we consecutively enrolled, at a single institution in Italy, men undergoing 12 core trans-rectal ultrasound-guided prostate needle biopsy. Indication for prostate biopsy was a PSA≥4ng/ml. Demographic, clinical and histopathological data were collected. PSA was tested 4 weeks before (PSA1 ) and the day before prostate biopsy (PSA2 )...
March 13, 2018: BJU International
Juha Knaapila, Heini Kallio, Antti J Hakanen, Kari Syvänen, Otto Ettala, Esa Kähkönen, Tarja Lamminen, Marjo Seppänen, Ivan Jambor, Antti Rannikko, Jarno Riikonen, Eveliina Munukka, Erkki Eerola, Marianne Gunell, Peter J Boström
OBJECTIVES: To determine, in a prospective, multicenter setting, the prevalence of fluoroquinolone (FQ) resistant and extended spectrum beta lactamase (ESBL) producing E. coli strains in men undergoing transrectal ultrasound guided prostate biopsy (TRUS-Bx) in Finland and to survey the associated risk factors for having the previously mentioned strains. MATERIALS AND METHODS: This is a substudy of the trial investigating the role of magnetic resonance imaging (MRI) in prostate cancer diagnosis (multi-IMPROD, NCT02241122)...
March 13, 2018: BJU International
Jihad Kaouk, Daniel Sagalovich, Juan Garisto
Prostate cancer (PCa) is the most common malignancy among men in the western world.1 Organ confined PCa treatment relies on a precise evaluation of the primary disease site. With the evolution of technology, prostate imaging modalities such as magnetic resonance imaging (MRI) are being used to localize PCa lesions dramatically impacting the management of this urologic malignancy2 . This article is protected by copyright. All rights reserved.
March 13, 2018: BJU International
Adriana C Vidal, Lauren E Howard, Amanda de Hoedt, Christopher J Kane, Martha K Terris, William J Aronson, Matthew R Cooperberg, Christopher L Amling, Stephen J Freedland
OBJECTIVE: At the population level, obesity is associated with prostate cancer (PC) mortality; however, some studies found higher body mass index (BMI) is associated with better long-term PC outcomes among men with metastatic castration-resistant PC (mCRPC). PATIENTS AND METHODS: We tested whether obesity was associated with progression to metastasis, PC-specific mortality (PCSM), and all-cause mortality (ACM) among 1192 non-metastatic CRPC patients from the SEARCH Database...
March 9, 2018: BJU International
Michael Chao, Huong Ho, Yee Chan, Alwin Tan, Trung Pham, Damien Bolton, Andrew Troy, Catherine Temelcos, Shomik Sengupta, Kevin McMillan, Chee Wee Cham, Madalena Liu, Wei Ding, Brindha Subramanian, Jason Wasiak, Daryl Lim Joon, Sandra Spencer, Nathan Lawrenstchuk
OBJECTIVE: The purpose of this study was to report on the dosimetric benefits and late toxicity outcomes following injection of a hydrogel spacer (HS) between the prostate and rectum for patients treated with prostate radiotherapy. METHODS: A total of 76 patients with a clinical stage of T1-T3a prostate cancer underwent general anaesthesia for fiducial marker insertion plus injection of the HS into the peri-rectal space prior to intensity modulated radiation therapy (IMRT) or volumetric modulated radiation therapy (VMAT)...
March 9, 2018: BJU International
Linda M Huynh, Kathryn Osann, Douglas Skarecky, Thomas E Ahlering
OBJECTIVE: To introduce a patient-reported erection fullness scale (% fullness) following robot-assisted radical prostatectomy as a qualitative adjunct to the IIEF-5 and as a 90-day predictor of two-year potency outcomes. PATIENTS AND METHODS: Prospective data was collected from 540 men with preoperative IIEF-5 22-25 who underwent RARP by a single surgeon, of which 299 had complete data at all time points up to 2 years. In addition to standard assessment tools (IIEF-5 and erections sufficient for intercourse), patients were asked to "indicate the fullness you are able to achieve in erections compared to before surgery?" (0-10…100%)...
March 9, 2018: BJU International
Tobias Gross, Marc Furrer, Petra Schorno, Patrick Y Wuethrich, Marc P Schneider, George N Thalmann, Fiona C Burkhard
OBJECTIVES: To compare functional and oncological outcomes of reproductive organ sparing cystectomy (ROSC) compared to standard cystectomy (SC) in females undergoing orthotopic ileal bladder substitution (OBS). PATIENTS AND METHODS: From 1995 to 2016, 121 consecutive females undergoing OBS were prospectively included in this single center non-randomized clinical follow up study including a ROSC and SC group. Urinary continence, the need for intermittent self-catheterization (ISC), lateral standing micturition cystourethrogram (MCUG), urethral pressure profiles findings, if available, and oncological outcomes were assessed and compared for ROSC or SC...
March 9, 2018: BJU International
Alex Tsui, Diana Kuh, Linda Cardozo, Daniel Davis
OBJECTIVE: To investigate the prevalence of urgency urinary incontinence (UUI) at age 68 years and the contribution of vascular risk factors to male and female UUI pathogenesis in addition to the associations with raised body mass index (BMI). SUBJECTS AND METHODS: In all, 1 762 participants from the Medical Research Council (MRC) National Survey for Health and Development birth cohort who answered the International Consultation on Incontinence Questionnaire short form (ICIQ-SF), at age 68 years, were included...
March 7, 2018: BJU International
Aruni Ghose, Hannah Rose Warren, Nicholas Tobias Johannes Raison, Prokar Dasgupta
Social media has undoubtedly revolutionised the way we communicate and connect with today's global village. With over a billion users and still growing, it has helped stoke academic discussion and transformed conferences through virtual mass dissemination of information. However, a recent controversy has brought to light the growing conflicts between academia and industry in this new age of unrestricted online information exchange. This article is protected by copyright. All rights reserved.
March 6, 2018: BJU International
P Chandak, N Byrne, H Lynch, C Allen, G Rottenberg, A Chandra, N Raison, H Ahmed, V Kasivisvanathan, O Elhage, P Dasgupta
The surgical management of prostate cancer has been shown to be determined by the anatomical location of the tumour and its associated intricate relationship to the neurovascular bundle and the prostatic capsule. Studies have shown an improvement in decision making about preservation or resection of neurovascular bundles during robotic assisted prostatectomy (RARP) [1,2] during which the surgeon lacks the tactile feedback of conventional open surgery. This article is protected by copyright. All rights reserved...
March 6, 2018: BJU International
E Volz-Sidiropoulou, T Rings, A Wagg, N Leistner, S Gauggel, R Kirschner-Hermanns
OBJECTIVES: To develop a new assessment tool to measure disease-related impact of incontinence and care effort in cognitively impaired adults (ICIQ-Cog). The current paper presents the initial psychometric properties of ICIQ-Cog and outlines some possible clinical implications. SUBJECTS/PATIENTS AND METHODS: The ICIQ-Cog consists of 2 scales: a 12-item scale measuring disease-specific bother (ICIQ-Cog-P) and a 4-item scale assessing care efforts (ICIQ-Cog-C). The data for 60 residents of nursing homes suffering from incontinence and cognitive impairments were obtained in a test-retest research design...
March 6, 2018: BJU International
Benoit Peyronnet, Lauranne Tondut, Jean-Christophe Bernhard, Christophe Vaessen, Nicolas Doumerc, Philippe Sebe, Benjamin Pradere, Bertrand Guillonneau, Zine-Eddine Khene, Francois-Xavier Nouhaud, Nicolas Brichart, Thomas Seisen, Quentin Alimi, Jean-Baptiste Beauval, Romain Mathieu, Adham Rammal, Alexandre De La Taille, Herve Baumert, Stéphane Droupy, Franck Bruyere, Morgan Roupret, Arnaud Mejean, Karim Bensalah
OBJECTIVE: To assess the impact of hospital volume (HV) and surgeon volume (SV) on perioperative outcomes of robot assisted partial nephrectomy (RAPN). PATIENTS AND METHODS: All consecutive patients who underwent a RAPN from 2009 to 2015 at eleven institutions were included in a retrospective study. To evaluate the impact of hospital volume we divided RAPN into four quartiles according to the caseload per year: low HV (<20/year); moderate HV (20-44/year); High HV (45-70/year); very high HV (>70/year)...
March 5, 2018: BJU International
Julia Han, Jae Hung Jung, Caitlin J Bakker, Mark H Ebell, Philipp Dahm
OBJECTIVES: To assess the effects of desmopressin as compared to other interventions in the treatment of nocturia in men. PATIENTS AND METHODS: We performed a comprehensive search using multiple databases and abstract proceedings with no restrictions on the language of publication or publication status, up until August 2017. We included randomized or quasi-randomized trials. Inclusion criteria were men with nocturia defined as one or more voids per night. Two review authors independently examined full-text reports, identified relevant studies, assessed the eligibility of studies for inclusion, extracted data and assessed risk of bias...
February 28, 2018: BJU International
David W Donnelly, Conan Donnelly, Therese Kearney, David Weller, Linda Sharp, Amy Downing, Sarah Wilding, Penny Wright, Paul Kind, James W F Catto, William R Cross, Malcolm D Mason, Eilis McCaughan, Richard Wagland, Eila Watson, Rebecca Mottram, Majorie Allen, Hugh Butcher, Luke Hounsome, Peter Selby, Dyfed Huws, David H Brewster, Emma McNair, Carol Rivas, Johana Nayoan, Mike Horton, Lauren Matheson, Adam W Glaser, Anna Gavin
OBJECTIVES: To provide intelligence on the prevalence of urinary, bowel and sexual dysfunction in Northern Ireland (NI) to act as a baseline for studies of prostate cancer (PCa) outcomes and to aid service provision within the general population. SUBJECTS AND METHODS: A cross-sectional postal survey of 10,000 men aged 40 and over in NI, age-matched to the distribution of men living with PCa. The EQ-5D-5L and EPIC-26 instruments were used to enable comparisons with PCa outcome studies...
February 28, 2018: BJU International
Yoshifumi Kadono, Takahiro Nohara, Shohei Kawaguchi, Renato Naito, Satoko Urata, Kazufumi Nakashima, Masashi Iijima, Kazuyoshi Shigehara, Kouji Izumi, Toshifumi Gabata, Atsushi Mizokami
OBJECTIVE: To assess the chronological changes in urinary incontinence and urethral function before and after radical prostatectomy (RP), and compared the findings of pelvic magnetic resonance imaging (MRI) before and after RP to evaluate the anatomical changes. PATIENTS AND METHODS: In total, 185 patients were evaluated for the position of the distal end of the membranous urethra (DMU) on a mid-sagittal MRI slice and for urethral sphincter function using the urethral pressure profilometry; they also underwent the abdominal leak point pressure test before RP and at 10 days and 12 months after RP...
February 28, 2018: BJU International
Christine Herforth, Sean P Stroup, Zinan Chen, Lauren E Howard, Stephen J Freedland, Daniel M Moreira, Martha K Terris, William J Aronson, Matthew R Cooperberg, Christopher L Amling, Christopher J Kane
OBJECTIVE: Positive surgical margins (PSM) after radical prostatectomy (RP) are a significant predictor of biochemical failure and possible disease progression. Close surgical margins (CSM) however represent a diagnostic challenge for surgeons. We sought to evaluate the biochemical recurrence (BCR) patterns among men undergoing RP with specimens having negative, positive, and close surgical margins from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. METHODS: Men undergoing RP between 1988 and 2015 with known final pathologic margin status were evaluated...
February 23, 2018: BJU International
Andrea Braga, Giorgio Caccia, Paola Sorice, Simona Cantaluppi, Anna Chiara Coluccia, Maria Carmela Di Dedda, Luca Regusci, Fabio Ghezzi, Stefano Uccella, Maurizio Serati
OBJECTIVE: To assess the efficacy and safety of retropubic tension-free vaginal tape (TVT) 17 years after implantation for the treatment of female pure stress urinary incontinence (SUI). PATIENTS AND METHODS: A prospective study was conducted in two urogynaecological units in two countries. All consecutive women with urodynamically proven pure SUI treated by TVT were included. Patients with mixed incontinence and/or anatomical evidence of pelvic organ prolapse were excluded...
February 22, 2018: BJU International
Donald Vaganée, Frederik Daems, William Aerts, Rosina Dewaide, Tinne van den Keybus, Karen De Baets, Stefan De Wachter, Gunter De Win
OBJECTIVES: To assess the presence of testicular asymmetry and its currently used cut-off values in varicocele management in a healthy adolescent population. PATIENTS AND METHODS: We conducted an observational cross-sectional study from April 2015 until December 2016 in which we recruited 539 adolescent boys aged 11 to 16 years. A clinical examination including testicular size measurement by ultrasonography was performed. Testicular volume (TV) was calculated using Lambert's formula (L*W*H*0...
February 20, 2018: BJU International
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