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BJU International

S Cashman, S Biers, T Greenwell, C Harding, R Morley, S Fowler, N Thiruchelvam
OBJECTIVES: To analyse the results of the British Association of Urological Surgeons' stress urinary incontinence audit, and present the contemporary management of stress urinary incontinence by UK urologists. PATIENTS AND METHODS: The BAUS audit tool is an online resource, to which all UK urologists performing procedures for stress urinary incontinence (SUI) are invited to submit data. The data entries for procedures performed 2014-2016 were collated and analysed...
September 17, 2018: BJU International
Thomas Steuber, Pierre Tennstedt, Annalisa Macagno, Alcibiade Athanasiou, Anja Wittig, Ramy Huber, Bruno Golding, Ralph Schiess, Silke Gillessen
OBJECTIVES: To investigated and further validate if two novel cancer-related glycoproteins - discovered by a genetic-guided proteomics approach - can distinguish benign disease from prostate cancer (PCa) in men with enlarged prostates. PATIENTS AND METHODS: A retrospective study was performed that included men with a total PSA of 2.0-10 ng/ml, negative digital rectal examination (DRE) and enlarged prostate volume (≥35 ml). Serum samples were collected between 2011 and 2016 at a single centre from 474 men before undergoing prostate biopsy...
September 14, 2018: BJU International
Irmina Maria Michalek, Jan Ivar Martinsen, Elisabete Weiderpass, Kristina Kjaerheim, Elsebeth Lynge, Pär Sparen, Laufey Tryggvadottir, Eero Pukkala
OBJECTIVES: To evaluate occupational variation in the incidence of the malignant neoplasm of the renal pelvis in the population of the Nordic countries. MATERIALS AND METHODS: The study cohort comprised of 14.9 million individuals. The data on occupational history were obtained from national censuses. Standardized incidence ratios (SIR) were calculated for each occupation. RESULTS: The highest SIRs were found in seamen (1.51, 95% confidence interval [CI] 1...
September 14, 2018: BJU International
Pan Song, Chuiguo Huang, Yan Wang, Wen Zhu, Yiwei Yue, Jinjin Feng, Xiangfei He, Qingwei Wang, Jianguo Wen
OBJECTIVE: To assess the efficacy of desmopressin (D), alarm (A), desmopressin plus alarm (DA), and desmopressin plus anticholinergic agent (DAA) in the management of pediatrics monosymptomatic nocturnal enuresis (MNE) by network meta-analysis. MATERIAL AND METHODS: We searched the electronic databases including PubMed, Cochrane Library, Embase and Web of Science from inception to March 1, 2018. The randomized controlled trials (RCTs) which compared D, A DA, DAA were identified...
September 14, 2018: BJU International
Maria I Van Rompay, J Curtis Nickel, Gayatri Ranganathan, Philip W Kantoff, Keith R Solomon, Jennifer L Lund, John B McKinlay
OBJECTIVE: To investigate the use of 5α-reductase inhibitors (5ARIs) and α-blockers among men with benign prostatic hyperplasia (BPH) in relation to prostate cancer (PC) incidence, severity, and mortality. PATIENTS AND METHODS: A retrospective 20-year cohort study in Saskatchewan men aged 40-89 years with a BPH-coded medical claim between 1995 and 2014 was conducted. Cox proportional hazards regression was used to compare incidence of a PC diagnosis, metastatic PC, Gleason score 8-10 PC, and PC mortality among 5ARI users (n=4,571), α-blocker users (n=7,764), and non-users (n=11,677)...
September 14, 2018: BJU International
Teppei Matsumoto, Shingo Hatakeyama, Atsushi Imai, Toshikazu Tanaka, Kazuhisa Hagiwara, Sakae Konishi, Kazutaka Okita, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Shigeyuki Nakaji, Chikara Ohyama
OBJECTIVE: We aimed to investigate the relationship between oxidative stress and LUTS in a community-dwelling population. MATERIALS AND METHODS: The cross-sectional study included 1113 subjects who participated in the Iwaki Health Promotion Project of 2015 in Hirosaki, Japan. LUTS were assessed using structured questionnaires including the International Prostate Symptom Score (IPSS) and the Overactive Bladder Symptom Score (OABSS). IPSS > 7, OABSS > 5, nocturia > 1, or urge incontinence > 1 were defined as moderate to severe symptoms...
September 14, 2018: BJU International
Geoffrey Hackett, Nigel Cole, Akhilesh Mulay, Richard C Strange, Sudarshan Ramachandran
OBJECTIVE: To further characterise the beneficial impact of testosterone replacement therapy (TRT) on the association between mortality and hypogonadism (HG) in men with type 2 diabetes (T2DM). We aimed to determine firstly, if changes in cardiovascular disease (CVD) risk factors following TRT play a role, secondly whether the reduction in mortality is lost following TRT discontinuation and finally, the presence of subgroups where benefit may be greater. MATERIALS AND METHODS: We studied 857 men with T2DM, screened for the BLAST RCT, over 3...
September 14, 2018: BJU International
Riccardo Bertolo, Riccardo Campi, Tobias Klatte, Maximilian C Kriegmair, Maria Carmen Mir, Idir Ouzaid, Maciej Salagierski, Sam Bhayani, Inderbir Gill, Jihad Kaouk, Umberto Capitanio
BACKGROUND: Precise tumor excision and renal reconstruction significantly affect the amount of vascularized parenchyma preserved during minimally-invasive partial nephrectomy (MIPN), which is a primary determinant of ultimate renal function. However, current knowledge on renorrhaphy techniques is sparse with no consensus on the best approach. OBJECTIVE: to summarize the available evidence on renorrhaphy techniques and to assess their impact on perioperative outcomes after MIPN...
September 14, 2018: BJU International
P Mourmouris, S Keskin, A Skolarikos, O B Argun, A A Karagiannis, I Tufek, C Obek, A R Kural
OBJECTIVE: To report the first prospective comparative analysis of robotic versus open simple prostatectomy for large prostate glands. MATERIALS AND METHODS: We prospectively analyzed 41 patients that underwent surgery for benign prostate hyperplasia from 2014-2017 at two university institutions. Patients were grouped according to the procedure (open or robotic) and matched in terms of age, prostate volume, BMI and PSA. The two groups were followed prospectively for 3 months and their postoperative and functional outcomes were compared...
September 10, 2018: BJU International
G Fraisse, L Colleter, B Peyronnet, Z Khene, Q Mandoorah, Y Soorojebally, A Bourgi, A De La Taille, M Roupret, E De Kerviler, F Desgrandchamps, K Bensalah, A Masson-Lecomte
OBJECTIVES: To compare the oncological outcomes of percutaneous cryoablation (PCA) versus robot-assisted partial nephrectomy (RPN) for the treatment of T1 renal tumors. MATERIALS AND METHODS: We included retrospectively all patients treated by RPN or PCA for malignant renal tumor in 4 centres between 2009 and 2016. Tumors were paired one by one using radiological tumor stage and RENAL score (package matchit, R software version 3.2.2). Malignancy was confirmed using biopsy for all patients in the PCA group...
August 28, 2018: BJU International
Giulia Lane, Michael Risk, Yunhua Fan, Suprita Krishna, Badrinath Konety
OBJECTIVES: To evaluate whether patients with persistent muscle-invasive bladder cancer (MIBC) after undergoing neoadjuvant chemotherapy (NAC) and radical cystectomy (RC) have worse overall survival (OS) and cancer-specific survival (CSS) than patients with similar pathology who undergo RC alone. MATERIALS AND METHODS: Using the Surveillance, Epidemiology and End Results (SEER)-Medicare database, we identified the records of patients with pT2-4N0M0 disease who underwent RC, with and without NAC, for MIBC between 2004 and 2011...
August 20, 2018: BJU International
Xavier Bonet, Gabriel Ogaya-Pinies, Tracey Woodlief, Eduardo Hernandez-Cardona, Hariharan Ganapathi, Travis Rogers, Rafael F Coelho, Bernardo Rocco, Francesc Vigués, Vipul Patel
OBJECTIVE: To show the feasibility, oncological and functional outcomes of neurovascular bundle (NVB) preservation during salvage robot-assisted radical prostatectomy (RARP). PATIENTS AND METHODS: In the present institutional review board-approved retrospective analysis, between January 2008 and March 2016, 80 patients underwent salvage RARP, performed by a single surgeon (V.P), because of local recurrence after primary treatment. These patients were categorized into two groups depending on the degree of nerve-sparing (NS) performed: a good-NS group (≥50% of NVB preservation) and a poor-NS group (<50% of NVB preservation)...
August 20, 2018: BJU International
Sangjun Yoo, Sohee Oh, Juhyun Park, Sung Yong Cho, Min Chul Cho, Hyeon Jeong, Hwancheol Son
OBJECTIVES: To investigate the influence of lifestyle, metabolic syndrome (MetS) on the prevalence of benign prostatic hyperplasia (BPH) requiring treatment using a large historical cohort. MATERIALS AND METHODS: This study included 130,454 men selected from the National Health Insurance Service health checkup database. Men were divided into the two groups according to the presence of MetS. A generalized estimating equation was performed to assess the predictors of BPH requiring treatment after adjusting other variables...
August 19, 2018: BJU International
Johannes Breyer, Ralph M Wirtz, Philipp Erben, Sebastien Rinaldetti, Thomas S Worst, Robert Stoehr, Markus Eckstein, Danijel Sikic, Stefan Denzinger, Maximilian Burger, Arndt Hartmann, Wolfgang Otto
OBJECTIVE: To investigate the role of forkhead box protein M1 (FOXM1) mRNA expression and its prognostic value in stage pT1 non-muscle-invasive bladder cancer (NMIBC). PATIENTS AND METHODS: Clinical data and formalin-fixed paraffin-embedded tissues from transurethral resection of the bladder from patients with stage pT1 NMIBC, treated with an organ-preserving approach, were analysed retrospectively. Total RNA was isolated using commercial RNA extraction kits, and mRNA expression of FOXM1, MKI67, KRT20 and KRT5 was measured by single-step quantitative RT-PCR using RNA-specific TaqMan Assays...
August 18, 2018: BJU International
Daniel G Wong, Michelle K Arevalo, Niccolo Maria Passoni, Nida S Iqbal, Thomas Jascur, Adam J Kern, Emma J Sanchez, Arthi Satyanarayan, Jyothsna Gattineni, Linda A Baker
OBJECTIVE: To design a novel system of scoring prune belly syndrome (PBS) phenotypic severity at any presenting age and apply it to a large pilot cohort. PATIENTS AND METHODS: From 2000 to 2017, patients with PBS were recruited to our prospective PBS study and medical records were cross-sectionally analysed, generating individualised RUBACE scores. We designed the pragmatic RUBACE-scoring system based on six sub-scores (R: renal, U: ureter, B: bladder/outlet, A: abdominal wall, C: cryptorchidism, E: extra-genitourinary, generating the acronym RUBACE), yielding a potential summed score of 0-31...
August 16, 2018: BJU International
Paras H Shah, Timothy D Lyon, Christine M Lohse, John C Cheville, Bradley C Leibovich, Stephen A Boorjian, R Houston Thompson
OBJECTIVE: To investigate the prognostic significance of various patterns of extrarenal extension that comprise pathological stage T3a clear-cell renal cell carcinoma (ccRCC) amongst patients undergoing nephrectomy for non-metastatic disease. PATIENTS AND METHODS: A retrospective review of 563 patients who underwent radical nephrectomy for pathologically confirmed T3aN0/NxM0 ccRCC between 1970 and 2011 was performed. All pathological slides were re-reviewed by one urological pathologist...
August 16, 2018: BJU International
Claire Pascoe, Catriona Duncan, Benjamin W Lamb, Niall F Davis, Thomas H Lynch, Declan G Murphy, Nathan Lawrentschuk
Haemorrhage is a frequent complication of radiation cystitis leading to emergency presentations in patients with prior pelvic radiation therapy. Standard initial patient management strategies involve resuscitation, bladder washout with clot evacuation and continuous bladder irrigation. Beyond this, definitive surgical treatment is associated with significant morbidity and mortality. Alternative less invasive management options for non-emergent haemorrhagic cystitis include systemic medical therapies, hyperbaric oxygen, intra-vesical therapies and laser ablation...
August 16, 2018: BJU International
Collene E Anderson, Jonviea D Chamberlain, Xavier Jordan, Thomas M Kessler, Eugenia Luca, Sandra Möhr, Jürgen Pannek, Martin Schubert, Martin W G Brinkhof
OBJECTIVE: To understand the occurrence of and risk factors for urinary tract infections (UTIs) in patients with spinal cord injury (SCI) undergoing specialized SCI rehabilitation in Switzerland. PATIENTS AND METHODS: This study used data collected from 369 patients, who participated in a nationwide rehabilitation cohort for SCI in Switzerland between 2013 and 2017. Information on UTIs as well as their potential determinants, including demographics, lesion characteristics, and time-updated data on functional independence and bladder management, was used...
August 16, 2018: BJU International
Mark Johnson, Amr Raheem, Francesco De Luca, Marcus Hallerstrom, Yasmeen Zainal, Sameer Poselay, Baharak Mohammadi, Amr Moubasher, Thomas Frederick Johnson, Asif Muneer, Philippa Sangster, David J Ralph
OBJECTIVE: To describe the prevalence of Y-chromosome microdeletions in a multi-ethnic urban population in London, UK. To also determine predictive factors and a clinical threshold for genetic testing in men with Y chromosome microdeletions. PATIENTS AND METHODS: A retrospective cohort study of 1473 men that were referred to a tertiary Andrology centre with male factor infertility between July 2004 and December 2016. All had a genetic evaluation, hormonal profile and 2 abnormal semen analyses...
August 16, 2018: BJU International
K M Gallagher, E Christopher, A J Cameron, S Little, A Innes, G Davis, J Keanie, P Bollina, S A McNeill
OBJECTIVES: This study aimed to report outcomes from a multi-parametric MRI (MP-MRI) based active surveillance programme that did not perform protocol biopsies after the first confirmatory biopsy. PATIENTS AND METHODS: All patients diagnosed with Gleason 3+3 prostate cancer because of a raised PSA who had MP-MRI scan after diagnosis were included. Patients were recorded in a prospective clinical database and followed up with PSA monitoring and repeat MRI scans. In patients who remained on active surveillance after the first MRI +/- confirmatory biopsy we investigated PSA dynamics for association with subsequent progression...
August 16, 2018: BJU International
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