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BJU International

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https://www.readbyqxmd.com/read/27873452/improving-clinical-prognostic-stratification-models-for-men-with-prostate-cancer-a-practical-step-closer-to-more-individualised-care-without-added-costs
#1
LETTER
Vincent J Gnanapragasam, Anne Y Warren
Risk stratification remains the cornerstone in deciding management for men with non-metastatic prostate cancer. Current risk stratification systems however have barely changed in two decades and have shown significant shortcomings with regards intra and inter-group heterogeneity in disease behaviour and therapy outcomes. A number of sophisticated and expensive molecular tests have been developed and more are being investigated to address this gap. However, new thinking on how to better use existing pathological information and refining clinical risk models may already offer significant incremental benefits in improving prognostic prediction without additional costs or resourcing...
November 22, 2016: BJU International
https://www.readbyqxmd.com/read/27868328/long-term-outcome-of-the-adjustable-transobturator-male-system-atoms-results-of-a-european-multicentre-study
#2
Alexander Friedl, Sandra Mühlstädt, Roman Zachoval, Alessandro Giammò, Danijel Kivaranovic, Maximilian Rom, Paolo Fornara, Clemens Brössner
OBJECTIVE: To evaluate the long-term effectiveness and safety of the adjustable transobturator male system (ATOMS(®) , Agency for Medical Innovations A.M.I., Feldkirch, Austria) in a European-wide multicentre setting. PATIENTS AND METHODS: In all, 287 men with stress urinary incontinence (SUI) were treated with the ATOMS device between June 2009 and March 2016. Continence parameters (daily pad test/pad use), urodynamics (maximum urinary flow rate, voiding volume, residual urine), and pain/quality of life (QoL) ratings (visual analogue scale/Leeds Assessment of Neuropathic Symptoms and Signs, International Consultation on Incontinence Questionnaire-Short Form [ICIQ-SF]/Patient Global Impression of Improvement [PGI-I]) were compared preoperatively and after intermediate (12 months) as well as after individual maximum follow-up...
November 21, 2016: BJU International
https://www.readbyqxmd.com/read/27862898/low-dose-desmopressin-combined-with-serum-sodium-monitoring-can-prevent-clinically-significant-hyponatraemia-in-patients-treated-for-nocturia
#3
Kristian Vinter Juul, Anders Malmberg, Egbert van der Meulen, Johan Vande Walle, Jens Peter Nørgaard
OBJECTIVE: To explore risk factors for desmopressin-induced hyponatraemia and evaluate the impact of a serum sodium monitoring plan. SUBJECTS AND METHODS: This was a meta-analysis of data from three clinical trials of desmopressin in nocturia. Participants received placebo or desmopressin orally disintegrating tablet ([ODT], 10-100 μg). Incidence of serum sodium <130 mmol/L was recorded by age, sex and dose. Potential predictors of clinically significant hyponatraemia were identified using multivariate analysis in a Cox proportional hazards model...
November 15, 2016: BJU International
https://www.readbyqxmd.com/read/27862828/introduction-of-robotically-assisted-radical-cystectomy-within-an-established-enhanced-recovery-programme
#4
Catherine Miller, Nicholas J Campain, Rachel Dbeis, Mark Daugherty, Nicholas Batchelor, Elizabeth Waine, John S McGrath
OBJECTIVES: In recent years, there has been rapid adoption of robotically-assisted surgery (RAS) for the treatment of pelvic urological cancers. This is particularly true for radical prostatectomy (RP) where robotically-assisted laparoscopic prostatectomy (RALP) has become the predominant surgical approach across England. Despite this, less than 15% of patients undergoing radical cystectomy (RC) in England in 2014 underwent a robotically-assisted radical cystectomy (RARC). However, as expertise in RAS spreads, an increasing number of cancer centres are now adopting this approach for patients undergoing RC...
November 15, 2016: BJU International
https://www.readbyqxmd.com/read/27862831/prostatic-urethral-lift-pul-vs-transurethral-resection-of-the-prostate-turp-2-year-results-of-the-bph6-prospective-multi-center-randomised-study
#5
C Gratzke, N Barber, M Speakman, R Berges, U Wetterauer, D Greene, K-D Sievert, C Chapple, J Sonksen
OBJECTIVES: To compare Prostatic Urethral Lift (PUL) to Transurethral Resection of the Prostate (TURP) with regard to symptoms, recovery experience, sexual function, continence, safety, quality of life, sleep and overall patient perception. SUBJECTS/PATIENTS AND METHODS: 80 patients with lower urinary tract symptoms due to benign prostatic hyperplasia (BPH) enrolled in a prospective, randomised, controlled, non-blinded study conducted at 10 European centers. The BPH6 responder endpoint assessed symptom relief, quality of recovery, erectile function preservation, ejaculatory function preservation, continence preservation, and safety...
November 14, 2016: BJU International
https://www.readbyqxmd.com/read/27860090/guideline-of-guidelines-priapism
#6
REVIEW
Asif Muneer, David Ralph
Priapism is defined as a prolonged penile erection lasting for more than 4 hours in the absence of sexual stimulation and remains despite orgasm. Current priapism guidelines for priapism have been published following a comprehensive literature review and expert consensus by the American Urological Association (AUA) and by an evidence review according to the Oxford Centre for Evidence based medicine by the European Association of Urology (EAU). Although there are both local and regional guidelines available throughout the UK, these tend to be adaptations of guidelines from larger urology organisations and there are currently no guidelines from the British Association of Urological Surgeons (BAUS)...
November 14, 2016: BJU International
https://www.readbyqxmd.com/read/27862869/multicentre-evaluation-of-target-and-systematic-biopsies-using-magnetic-resonance-and-ultrasound-image-fusion-guided-transperineal-prostate-biopsy-in-patients-with-a-previous-negative-biopsy
#7
N L Hansen, C Kesch, T Barrett, B Koo, J P Radtke, D Bonekamp, H P Schlemmer, A Y Warren, K Wieczorek, M Hohenfellner, C Kastner, B Hadaschik
OBJECTIVES: To evaluate the detection rates of targeted and systematic biopsies in magnetic resonance (MRI) and transrectal ultrasound (US) image-fusion transperineal prostate biopsy for patients with previous benign transrectal US guided biopsies in two high-volume centres. PATIENTS AND METHODS: Two centre, prospective outcome study of 487 patients with previous benign biopsies that underwent transperineal MRI/US fusion-guided target and systematic saturation biopsy from 2012 to 2015...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27862866/utility-of-patient-specific-silicone-renal-models-for-planning-and-rehearsal-of-complex-tumor-resections-prior-to-robotic-assisted-laparoscopic-partial-nephrectomy
#8
Friedrich-Carl von Rundstedt, Jason M Scovell, Smriti Agrawal, Jacques Zaneveld, Richard E Link
OBJECTIVE: Surgical planning for robotic partial nephrectomy (RALPN) depends on preoperative imaging and interpretation of spatial relationships between tumor and renal anatomy. We describe our experience using patient specific tissue-like kidney models created with advanced 3D printing technology for preoperative planning and surgical rehearsal prior to RALPN . PATIENTS AND METHODS: A feasibility study of 10 patients with solid renal masses who underwent RALPN after preoperative rehearsal using 3D print models...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27862863/value-of-111-in-psma-radioguided-surgery-for-salvage-lymphadenectomy-in-recurrent-prostate-cancer-correlation-with-histopathology-and-clinical-follow-up
#9
Isabel Rauscher, Charlotte Düwel, Martina Wirtz, Margret Schottelius, Hans-Jürgen Wester, Kristina Schwamborn, Bernhard Haller, Markus Schwaiger, Jürgen E Gschwend, Matthias Eiber, Tobias Maurer
OBJECTIVES: To evaluate the use of (111) In-labeled PSMA-I&T based radioguided surgery ((111) In-PSMA-RGS) for salvage surgery in recurrent prostate cancer (PC) using comparison of intraoperative γ-probe measurements to histopathological results of dissected specimens. Furthermore, the success of (111) In-PSMA-RGS was determined by postoperative prostate-specific antigen (PSA) responses, PC-specific treatment-free survival as well as postoperative complication rates. PATIENTS AND METHODS: In this study, 31 consecutive patients with localized recurrent PC undergoing salvage surgery with PSMA-targeted RGS using an (111) In-labeled PSMA ligand were retrospectively included from April 2014 to July 2015...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27862832/risk-stratification-a-tool-to-predict-the-course-of-active-surveillance-for-localized-prostate-cancer
#10
Jan Herden, Axel Heidenreich, Lothar Weissbach
OBJECTIVE: To investigate a cohort of patients under active surveillance (AS) for localized prostate cancer (PCa) concerning possible differences in discontinuation rates, subsequent therapies, reasons for intervention, and pathologic findings after deferred surgery depending on stratification in very low-, low-, and intermediate/high-risk PCa. PATIENTS AND METHODS: HAROW is a non-interventional, observational, outcomes research study on the management of localized PCa in the community setting...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27862825/competency-based-training-in-robotic-surgery-benchmark-scores-for-virtual-reality-robotic-simulation
#11
N Raison, K Ahmed, N Fossati, N Buffi, A Mottrie, P Dasgupta, H van der Poel
OBJECTIVES: To develop benchmark scores of competency for use within a competency-based virtual reality (VR) robotic training curriculum. SUBJECTS AND METHODS: This longitudinal, observational study analysed results from 9 EAU hands-on-training courses in VR simulation. 223 participants ranging from novice to expert robotic surgeons completed 1565 exercises. Competency was set at 75% of the mean expert score. Benchmark scores for all general performances metrics generated by the simulator were calculated...
November 10, 2016: BJU International
https://www.readbyqxmd.com/read/27862836/36-month-data-for-the-advance-xp-%C3%A2-male-sling-results-of-a-prospective-multicentre-study
#12
Ricarda M Bauer, Markus T Grabbert, Benedikt Klehr, Peter Gebhartl, Christian Gozzi, Roland Homberg, Florian May, Peter Rehder, Christian G Stief, Alexander Kretschmer
OBJECTIVES: To evaluate the efficacy and safety of the AdVance XP(®) sling (Boston Scientific, formerly American Medical Systems) in male stress urinary incontinence (SUI) after radical prostatectomy in a prospective multicentre study, as in recent years several studies have shown the effectiveness and safety of the AdVance sling for treating male SUI and in 2010 the second-generation AdVance XP was introduced with several changes in the sling design and a new needle shape. PATIENTS AND METHODS: In all, 115 patients were included...
November 8, 2016: BJU International
https://www.readbyqxmd.com/read/27862806/a-prospective-and-randomised-trial-comparing-fluoroscopic-total-ultrasonographic-and-combined-guidance-for-renal-access-in-mini-percutaneous-nephrolithotomy
#13
Wei Zhu, Jiasheng Li, Jian Yuan, Yongda Liu, Shaw P Wan, Guanzhao Liu, Wenzhong Chen, Wenqi Wu, Jintai Luo, Dongliang Zhong, Defeng Qi, Ming Lei, Wen Zhong, Ze Zhang, Zhaohui He, Zhijian Zhao, Suilin Lu, Yuji Wu, Guohua Zeng
OBJECTIVE: To compare the safety and efficacy of fluoroscopic guidance (FG), total ultrasonographic guidance (USG), and combined ultrasonographic and fluoroscopic guidance (CG) for percutaneous renal access in mini-percutaneous nephrolithotomy (mini-PCNL). PATIENTS AND METHODS: The present study was conducted between July 2014 and May 2015 as a prospective randomised trial at the First Affiliated Hospital of Guangzhou Medical University. In all, 450 consecutive patients with renal stones of >2 cm were randomised to undergo FG, USG, or CG mini-PCNL (150 patients for each group)...
November 8, 2016: BJU International
https://www.readbyqxmd.com/read/27862788/robot-assisted-partial-nephrectomy-continued-refinement-of-outcomes-beyond-the-initial-learning-curve
#14
David J Paulucci, Ronney Abaza, Daniel D Eun, Ashok K Hemal, Ketan K Badani
OBJECTIVES: To evaluate trends in peri-operative outcomes of 250 consecutive cases beyond the initial learning curve (LC) of robot-assisted partial nephrectomy (RAPN) among multiple surgeons. PATIENTS AND METHODS: A multi-institutional database was used to evaluate trends in patient demographics (e.g. age, gender, comorbidities), tumour characteristics (e.g. size, complexity) and peri-operative outcomes (e.g. warm ischaemia time [WIT], operating time, complications, estimated blood loss [EBL], trifecta achievement) in consecutive cases 50-300 (n = 960) from 2008 to 2016 among four experienced surgeons...
November 8, 2016: BJU International
https://www.readbyqxmd.com/read/27860163/11c-acetate-pet-ct-imaging-for-detection-of-recurrent-disease-following-radical-prostatectomy-or-radiotherapy-in-patients-with-prostate-cancer
#15
L Esch, M Fahlbusch, P Albers, H Hautzel, V Müller-Mattheis
OBJECTIVES: To evaluate the effectiveness of CT-matched 11C-acetate PET (AC-PET) in prostate cancer patients with PSA relapse following radical prostatectomy (RP) or radiotherapy (RT) in a prospective study. SUBJECTS AND METHODS: In 103 relapsing patients after RP (n=97) or RT (n=6) AC-PET images and CT scans were obtained. In PET positive patients with localized recurrence detected lesions were resected and histologically verified or -after local RT- followed-up by PSA testing...
November 8, 2016: BJU International
https://www.readbyqxmd.com/read/27860149/management-and-outcomes-of-patients-with-renal-medullary-carcinoma-a-multi-center-collaborative-study
#16
Amishi Y Shah, Jose A Karam, Gabriel G Malouf, Priya Rao, Zita D Lim, Eric Jonasch, Lianchun Xiao, Jianjun Gao, Ulka N Vaishampayan, Daniel Y Heng, Elizabeth R Plimack, Elizabeth A Guancial, Chunkit Fung, Stefanie R Lowas, Pheroze Tamboli, Kanishka Sircar, Surena F Matin, W Kimryn Rathmell, Christopher G Wood, Nizar M Tannir
OBJECTIVE: To describe the management strategies and outcomes of patients with renal medullary carcinoma (RMC) and characterize predictors of overall survival (OS). PATIENTS AND METHODS: RMC is a rare and aggressive malignancy that afflicts young patients with sickle cell trait; there are limited data on management to date. This is a study of patients with RMC who were treated during 2000-2015 at eight academic institutions in North America and France. The Kaplan-Meier method was used to estimate OS, measured from initial RMC diagnosis to date of death...
November 8, 2016: BJU International
https://www.readbyqxmd.com/read/27801536/contemporary-minimally-invasive-surgery-for-adrenal-masses-it-s-not-all-about-pure-laparoscopy
#17
LETTER
Nicola Pavan, Ithaar Derweesh, Jens Rassweiler, Benjamin Challacombe, Homayoun Zargar, James Porter, Evangelos Liatsikos, Jihad Kaouk, Francesco Porpiglia, Riccardo Autorino
No abstract text is available yet for this article.
November 1, 2016: BJU International
https://www.readbyqxmd.com/read/27797436/radio-guided-sentinel-lymph-node-detection-and-lymph-node-mapping-in-invasive-urinary-bladder-cancer-a-prospective-clinical-study
#18
F Aljabery, I Shabo, Hans Olson, Oliver Gimm, Staffan Jahnson
OBJECTIVES: We investigated the possibility to detect sentinel nodes in patients with urinary bladder cancer (UBC) intra-operatively and whether the histopathological status of the identified sentinel nodes reflected that of the lymphatic field. PATIENTS AND METHODS: We studied 103 patients with UBC pathological stage T1-T4 who were treated with cystectomy and pelvic lymph node (LN) dissection during 2005-2011 at the Department of Urology, Linköping University Hospital...
October 31, 2016: BJU International
https://www.readbyqxmd.com/read/27779799/diagnosis-and-long-term-outcome-of-renal-cysts-after-laparoscopic-partial-nephrectomy-in-children
#19
Ciro Esposito, Maria Escolino, Bernardita Troncoso Solar, Roberta Iacona, Rosanna Esposito, Alessandro Settimi, Imran Mushtaq
OBJECTIVE: To document the imaging follow-up of laparoscopic partial nephrectomy (LPN) in children and to investigate the natural history of cystic lesions following LPN. PATIENTS AND METHODS: We reviewed the ultrasonography (US) imaging reports performed during the follow-up of 125 children (77 girls, 48 boys; mean age 3.2 years) who underwent LPN in two centres of paediatric surgery in the period 2005-2015. RESULTS: A transperitoneal approach was adopted in 83 children and a retroperitoneal approach in 42...
October 25, 2016: BJU International
https://www.readbyqxmd.com/read/27763717/additive-effects-of-the-rho-kinase-inhibitor-y-27632-and-vardenafil-on-relaxation-of-the-corpus-cavernosum-tissue-of-patients-with-erectile-dysfunction-and-clinical-phosphodiesterase-type-5-inhibitor-failure
#20
Pieter Uvin, Maarten Albersen, Ine Bollen, Maarten Falter, Emmanuel Weyne, Loes Linsen, Hanna Tinel, Peter Sandner, Trinity J Bivalacqua, Dirk J M K De Ridder, Frank Van der Aa, Bert Brône, Koenraad Van Renterghem
OBJECTIVES: To evaluate the expression of the Rho/Rho-associated protein kinase (ROCK) pathway in the corpus cavernosum of patients with severe erectile dysfunction (ED) compared with healthy human corpus cavernosum, and to test the functional effects of two Rho kinase inhibitors (RKIs) on erectile tissue of patients with severe ED, which did not respond to phosphodiesterase type 5 inhibitors (PDE5Is). PATIENTS AND METHODS: Human corpus cavernosum samples were obtained after consent from men undergoing penile prosthesis implantation (n = 7 for organ bath experiments, n = 17 for quantitative PCR [qPCR])...
October 20, 2016: BJU International
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