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Arteriosclerosis, Thrombosis, and Vascular Biology

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https://www.readbyqxmd.com/read/30354252/contribution-of-the-tnf-%C3%AE-tumor-necrosis-factor-%C3%AE-tnf-rp55-tumor-necrosis-factor-receptor-p55-axis-in-the-resolution-of-venous-thrombus
#1
Mizuho Nosaka, Yuko Ishida, Akihiko Kimura, Yumi Kuninaka, Akira Taruya, Machi Furuta, Naofumi Mukaida, Toshikazu Kondo
Objective- Deep vein thrombosis results from a combination of risk factors including genetic conditions, obesity, drugs, pregnancy, aging, and malignancy. We examined pathophysiological roles of the TNF-α (tumor necrosis factor-α)-TNF-Rp55 (tumor necrosis factor receptor p55) axis in thrombus resolution using Tnfrp55-/- (TNF-Rp55-deficient) mice. Approach and Results- On ligating the inferior vena cava of wild-type (WT) mice, venous thrombi formed and grew progressively until 5 days but shrunk to <50% of the thrombus weight at day 14...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354251/endothelial-specific-cre-mouse-models
#2
Sophie Payne, Sarah De Val, Alice Neal
The field of vascular biology has gained enormous insight from the use of Cre and inducible Cre mouse models to temporally and spatially manipulate gene expression within the endothelium. Models are available to constitutively or inducibly modulate gene expression in all or a specified subset of endothelial cells. However, caution should be applied to both the selection of allele and the analysis of resultant phenotype: many similarly named Cre models have divergent activity patterns while ectopic or inconsistent Cre or inducible Cre expression can dramatically affect results...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354250/hippo-pathway-looms-large-for-the-function-of-the-jcad-junctional-protein-associated-with-coronary-artery-disease-on-endothelial-cells
#3
EDITORIAL
Rajat M Gupta
No abstract text is available yet for this article.
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354249/microfluidic-modeling-of-thrombolysis
#4
Stéphane Loyau, Benoit Ho-Tin-Noé, Marie-Charlotte Bourrienne, Yacine Boulaftali, Martine Jandrot-Perrus
Objective- Despite the high clinical relevance of thrombolysis, models for its study in human flowing blood are lacking. Our objective was to develop a microfluidic model for comparative evaluation of thrombolytic therapeutic strategies. Approach and Results- Citrated human blood was supplemented with 3,3'-dihexyloxacarbocyanine iodide and Alexa Fluor 647 fibrinogen conjugate, recalcified, and perfused for 3 to 4 minutes at venous or arterial wall shear rate in microfluidic flow chambers coated with collagen and tissue factor to generate nonocclusive fluorescent thrombi...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354248/mechanisms-by-which-lrp1-low-density-lipoprotein-receptor-related-protein-1-maintains-arterial-integrity
#5
EDITORIAL
Steven L Gonias
No abstract text is available yet for this article.
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354247/mannose-binding-lectin-drives-platelet-inflammatory-phenotype-and-vascular-damage-after-cerebral-ischemia-in-mice-via-il-interleukin-1%C3%AE
#6
Franca Orsini, Stefano Fumagalli, Eszter Császár, Krisztina Tóth, Daiana De Blasio, Rosalia Zangari, Nikolett Lénárt, Ádám Dénes, Maria-Grazia De Simoni
Objective- Circulating complement factors are activated by tissue damage and contribute to acute brain injury. The deposition of MBL (mannose-binding lectin), one of the initiators of the lectin complement pathway, on the cerebral endothelium activated by ischemia is a major pathogenic event leading to brain injury. The molecular mechanisms through which MBL influences outcome after ischemia are not understood yet. Approach and Results- Here we show that MBL-deficient (MBL-/- ) mice subjected to cerebral ischemia display better flow recovery and less plasma extravasation in the brain than wild-type mice, as assessed by in vivo 2-photon microscopy...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354246/myeloid-hmg-coa-3-hydroxy-3-methylglutaryl-coenzyme-a-reductase-determines-atherosclerosis-by-modulating-migration-of-macrophages
#7
Kent Sakai, Shuichi Nagashima, Tetsuji Wakabayashi, Bayasgalan Tumenbayar, Hiroko Hayakawa, Morisada Hayakawa, Tadayoshi Karasawa, Ken Ohashi, Hisataka Yamazaki, Akihito Takei, Shoko Takei, Daisuke Yamamuro, Manabu Takahashi, Hiroaki Yagyu, Jun-Ichi Osuga, Masafumi Takahashi, Shin-Ichi Tominaga, Shun Ishibashi
Objective- Inhibition of HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is atheroprotective primarily by decreasing plasma LDL (low-density lipoprotein)-cholesterol. However, it is unknown whether inhibition of HMGCR in myeloid cells contributes to this atheroprotection. We sought to determine the role of myeloid HMGCR in the development of atherosclerosis. Approach and Results- We generated mice with genetically reduced Hmgcr in myeloid cells ( Hmgcr m- /m - ) using LysM (Cre) and compared various functions of their macrophages to those of Hmgcr fl/fl control mice...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354245/palmitoylethanolamide-promotes-a-proresolving-macrophage-phenotype-and-attenuates-atherosclerotic-plaque-formation
#8
Petteri Rinne, Raquel Guillamat-Prats, Martina Rami, Laura Bindila, Larisa Ring, Leo-Pekka Lyytikäinen, Emma Raitoharju, Niku Oksala, Terho Lehtimäki, Christian Weber, Emiel P C van der Vorst, Sabine Steffens
Objective- Palmitoylethanolamide is an endogenous fatty acid mediator that is synthetized from membrane phospholipids by N-acyl phosphatidylethanolamine phospholipase D. Its biological actions are primarily mediated by PPAR-α (peroxisome proliferator-activated receptors α) and the orphan receptor GPR55. Palmitoylethanolamide exerts potent anti-inflammatory actions but its physiological role and promise as a therapeutic agent in chronic arterial inflammation, such as atherosclerosis remain unexplored. Approach and Results- First, the polarization of mouse primary macrophages towards a proinflammatory phenotype was found to reduce N-acyl phosphatidylethanolamine phospholipase D expression and palmitoylethanolamide bioavailability...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354244/recent-highlights-of-atvb
#9
Jacqueline S Dron, Julieta Lazarte, Robert A Hegele
No abstract text is available yet for this article.
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354243/lrp1-low-density-lipoprotein-receptor-related-protein-1-regulates-smooth-muscle-contractility-by-modulating-ca-2-signaling-and-expression-of-cytoskeleton-related-proteins
#10
Dianaly T Au, Zhekang Ying, Erick O Hernández-Ochoa, William E Fondrie, Brian Hampton, Mary Migliorini, Rebeca Galisteo, Martin F Schneider, Alan Daugherty, Debra L Rateri, Dudley K Strickland, Selen C Muratoglu
Objective- Mutations affecting contractile-related proteins in the ECM (extracellular matrix), microfibrils, or vascular smooth muscle cells can predispose the aorta to aneurysms. We reported previously that the LRP1 (low-density lipoprotein receptor-related protein 1) maintains vessel wall integrity, and smLRP1-/- mice exhibited aortic dilatation. The current study focused on defining the mechanisms by which LRP1 regulates vessel wall function and integrity. Approach and Results- Isometric contraction assays demonstrated that vasoreactivity of LRP1-deficient aortic rings was significantly attenuated when stimulated with vasoconstrictors, including phenylephrine, thromboxane receptor agonist U-46619, increased potassium, and L-type Ca2+ channel ligand FPL-64176...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354242/tnf-%C3%AE-tumor-necrosis-factor-%C3%AE
#11
EDITORIAL
Prakash Saha, Alberto Smith
No abstract text is available yet for this article.
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354241/unlocking-the-molecular-secrete-s-of-%C3%AE-granule-biogenesis
#12
EDITORIAL
Leila J Noetzli, Joseph E Italiano
No abstract text is available yet for this article.
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354240/endothelial-mitochondrial-preprotein-translocase-tomm7-rac1-signaling-axis-dominates-cerebrovascular-network-homeostasis
#13
Dan Shi, Man Qi, Liping Zhou, Xiang Li, Le Ni, Changming Li, Tianyou Yuan, Yunqian Wang, Yongli Chen, Chaoyue Hu, Dandan Liang, Li Li, Yi Liu, Jun Li, Yi-Han Chen
Objective- Mitochondria are the important yet most underutilized target for cardio-cerebrovascular function integrity and disorders. The Tom (translocases of outer membrane) complex are the critical determinant of mitochondrial homeostasis for making organs acclimate physiological and pathological insults; however, their roles in the vascular system remain unknown. Approach and Results- A combination of studies in the vascular-specific transgenic zebrafish and genetically engineered mice was conducted. Vascular casting and imaging, endothelial angiogenesis, and mitochondrial protein import were performed to dissect potential mechanisms...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354239/inflammasome-activation-aggravates-cutaneous-xanthomatosis-and-atherosclerosis-in-acat1-acyl-coa-cholesterol-acyltransferase-1-deficiency-in-bone-marrow
#14
Tetsuji Wakabayashi, Manabu Takahashi, Daisuke Yamamuro, Tadayoshi Karasawa, Akihito Takei, Shoko Takei, Hisataka Yamazaki, Shuichi Nagashima, Ken Ebihara, Masafumi Takahashi, Shun Ishibashi
Objective- ACAT1 (Acyl-CoA cholesterol acyltransferase 1) esterifies cellular free cholesterol, thereby converting macrophages to cholesteryl ester-laden foam cells in atherosclerotic lesions and cutaneous xanthoma. Paradoxically, however, loss of ACAT1 in bone marrow causes the aggravation of atherosclerosis and the development of severe cutaneous xanthoma in hyperlipidemic mice. Recently, it has been reported that cholesterol crystals activate NLRP3 (NACHT, LRR [leucine-rich repeats], and PYD [pyrin domain] domain-containing protein 3) inflammasomes, thereby contributing to the development of atherosclerosis...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354238/v-atpase-vacuolar-atpase-activity-required-for-abca1-atp-binding-cassette-protein-a1-mediated-cholesterol-efflux
#15
Shuhui Wang Lorkowski, Gregory Brubaker, Kailash Gulshan, Jonathan D Smith
Objective- We have shown that ABCA1 (ATP-binding cassette protein A1) mediates unfolding of the apoA1 (apolipoprotein A1) N-terminal helical hairpin during apoA1 lipidation. Others have shown that an acidic pH exposes the hydrophobic surface of apoA1. We postulated that the V-ATPase (vacuolar ATPase) proton pump facilitates apoA1 unfolding and promotes ABCA1-mediated cholesterol efflux. Approach and Results- We found that V-ATPase inhibitors dose-dependently decreased ABCA1-mediated cholesterol efflux to apoA1 in baby hamster kidney cells and RAW264...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354237/differential-gene-expression-in-macrophages-from-human-atherosclerotic-plaques-shows-convergence-on-pathways-implicated-by-genome-wide-association-study-risk-variants
#16
Joshua T Chai, Neil Ruparelia, Anuj Goel, Theodosios Kyriakou, Luca Biasiolli, Laurienne Edgar, Ashok Handa, Martin Farrall, Hugh Watkins, Robin P Choudhury
Objective- Plaque macrophages are intricately involved in atherogenesis and plaque destabilization. We sought to identify functional pathways in human plaque macrophages that are differentially regulated in respect of (1) plaque stability and (2) lipid content. We hypothesized that differentially regulated macrophage gene sets would relate to genome-wide association study variants associated with risk of acute complications of atherosclerosis. Approach and Results- Forty patients underwent carotid magnetic resonance imaging for lipid quantification before endarterectomy...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354236/impaired-hdl-high-density-lipoprotein-mediated-macrophage-cholesterol-efflux-in-patients-with-abdominal-aortic-aneurysm-brief-report
#17
Diego Martínez-López, Lídia Cedó, Jari Metso, Elena Burillo, Annabel García-León, Marina Canyelles, Jes S Lindholt, Monica Torres-Fonseca, Luis Miguel Blanco-Colio, Jesús Vázquez, Francisco Blanco-Vaca, Matti Jauhiainen, Jose Luis Martín-Ventura, Joan Carles Escolà-Gil
Objective- The ability of HDL (high-density lipoprotein) to promote macrophage cholesterol efflux is considered the main HDL cardioprotective function. Abdominal aortic aneurysm (AAA) is usually characterized by cholesterol accumulation and macrophage infiltration in the aortic wall. Here, we aim to evaluate the composition of circulating HDL particles and their potential for promoting macrophage cholesterol efflux in AAA subjects. Approach and Results- First, we randomly selected AAA and control subjects from Spain...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354235/transfusion-of-platelets-loaded-with-recombinant-adamts13-a-disintegrin-and-metalloprotease-with-thrombospondin-type-1-repeats-13-is-efficacious-for-inhibiting-arterial-thrombosis-associated-with-thrombotic-thrombocytopenic-purpura
#18
Mohammad S Abdelgawwad, Wenjing Cao, Liang Zheng, Nicole K Kocher, Lance A Williams, X Long Zheng
Objective- ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats-13) cleaves VWF (von Willebrand factor). This process is essential for hemostasis. Severe deficiency of plasma ADAMTS13 activity, most commonly resulting from autoantibodies against ADAMTS13, causes thrombotic thrombocytopenic purpura. Therapeutic plasma exchange is the standard of care to date, which removes autoantibodies and replenishes ADAMTS13. However, such a therapy is often ineffective to raise plasma ADAMTS13 activity, and in-hospital mortality rate remains as high as 20%...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354234/endothelial-fn-fibronectin-deposition-by-%C3%AE-5%C3%AE-1-integrins-drives-atherogenic-inflammation
#19
Zaki Al-Yafeai, Arif Yurdagul, Jonette M Peretik, Mabruka Alfaidi, Patrick A Murphy, A Wayne Orr
Objective- Alterations in extracellular matrix quantity and composition contribute to atherosclerosis, with remodeling of the subendothelial basement membrane to an FN (fibronectin)-rich matrix preceding lesion development. Endothelial cell interactions with FN prime inflammatory responses to a variety of atherogenic stimuli; however, the mechanisms regulating early atherogenic FN accumulation remain unknown. We previously demonstrated that oxLDL (oxidized low-density lipoprotein) promotes endothelial proinflammatory gene expression by activating the integrin α5β1, a classic mediator of FN fibrillogenesis...
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/30354233/platelets-can-soak-it-up-and-then-spit-it-out
#20
EDITORIAL
Kandace Gollomp, David F Friedman, Mortimer Poncz
No abstract text is available yet for this article.
November 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
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