journal
MENU ▼
Read by QxMD icon Read
search

Arteriosclerosis, Thrombosis, and Vascular Biology

journal
https://www.readbyqxmd.com/read/29326316/fibronectin-containing-extra-domain-a-induces-plaque-destabilization-in-the-innominate-artery-of-aged-apolipoprotein-e-deficient-mice
#1
Prakash Doddapattar, Manish Jain, Nirav Dhanesha, Steven R Lentz, Anil K Chauhan
OBJECTIVE: Fibronectin containing extra domain A (Fn-EDA) is an endogenous ligand of TLR4 (toll-like receptor 4) and is abundant in the extracellular matrix of advanced atherosclerotic lesions in human and mice. Irrespective of sex, deletion of Fn-EDA reduces early atherosclerosis in apolipoprotein E-deficient (Apoe-/-) mice. However, the contribution of Fn-EDA in advanced atherosclerosis remains poorly characterized. We determined the contribution of Fn-EDA in advanced atherosclerotic lesions of aged (1-year-old) Apoe-/- mice...
January 11, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29326315/plasma-n-3-and-n-6-fatty-acids-are-differentially-related-to-carotid-plaque-and-its-progression-mesa-the-multi-ethnic-study-of-atherosclerosis
#2
Brian T Steffen, Weihua Guan, James H Stein, Mathew C Tattersall, Joel D Kaufman, Veit Sandfort, Moyses Szklo, Michael Y Tsai
OBJECTIVE: ω-3 (n-3) fatty acids (FAs) have long been considered healthful dietary components, yet recent clinical trials have questioned their cardiovascular benefits. By contrast, the ω-6 (n-6) FAs have been considered harmful, proatherogenic macronutrients, despite an absence of empirical evidence supporting this hypothesis. We aimed to determine whether plasma n-3 and n-6 FAs are related to risk of carotid plaque and its progression in 3327 participants of the MESA (Multi-Ethnic Study of Atherosclerosis)...
January 11, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29326314/high-density-lipoprotein-cholesterol-and-mortality-too-much-of-a-good-thing
#3
Mark Hamer, Gary O'Donovan, Emmanuel Stamatakis
OBJECTIVE: The objective of this study was to examine the shape of the association between high-density lipoprotein cholesterol (HDL-C) and mortality in a large general population sample. APPROACH AND RESULTS: Adult participants (n=37 059; age=57.7±11.9 years; 46.8% men) were recruited from general population household-based surveys (Health Survey for England and Scottish Health Survey). Individual participant data were linked with the British National Health Service Central Registry to record mortality...
January 11, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29326313/dna-methylation-and-age-independent-cardiovascular-risk-an-epigenome-wide-approach-the-regicor-registre-giron%C3%A3-del-cor-study
#4
Alba Fernández-Sanlés, Sergi Sayols-Baixeras, Santiago Curcio, Isaac Subirana, Jaume Marrugat, Roberto Elosua
OBJECTIVE: The objectives of this study were to decipher whether age-independent cardiovascular risk is associated with DNA methylation at 5'-cytosine-phosphate-guanine-3' (CpG) level and to determine whether these differential methylation signatures are associated with the incidence of cardiovascular events. APPROACH AND RESULTS: We designed a 2-stage, cross-sectional, epigenome-wide association study. Age-independent cardiovascular risk calculation was based on vascular age and on the residuals of the relationship between age and cardiovascular risk...
January 11, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29326312/foxo3a-forkhead-transcription-factor-o-subfamily-member-3a-links-vascular-smooth-muscle-cell-apoptosis-matrix-breakdown-atherosclerosis-and-vascular-remodeling-through-a-novel-pathway-involving-mmp13-matrix-metalloproteinase-13
#5
Haixiang Yu, Adam Fellows, Kirsty Foote, Zhaoqing Yang, Nichola Figg, Trevor Littlewood, Martin Bennett
OBJECTIVE: Vascular smooth muscle cell (VSMC) apoptosis accelerates atherosclerosis and promotes breakdown of the extracellular matrix, but the mechanistic links between these 2 processes are unknown. The forkhead protein FOXO3a (forkhead transcription factor O subfamily member 3a) is activated in human atherosclerosis and induces a range of proapoptotic and other transcriptional targets. We, therefore, determined the mechanisms and consequences of FOXO3a activation in atherosclerosis and arterial remodeling after injury...
January 11, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29301790/chronic-kidney-disease-circulating-calciprotein-particles-and-extracellular-vesicles-promote-vascular-calcification-a-role-for-grp-gla-rich-protein
#6
Carla S B Viegas, Lúcia Santos, Anjos L Macedo, António A Matos, Ana P Silva, Pedro L Neves, An Staes, Kris Gevaert, Rute Morais, Cees Vermeer, Leon Schurgers, Dina C Simes
OBJECTIVE: Inhibition of mineral crystal formation is a crucial step in ectopic calcification. Serum calciprotein particles (CPPs) have been linked to chronic kidney disease (CKD) calcification propensity, but additional knowledge is required to understand their function, assemblage, and composition. The role of other circulating nanostructures, such as extracellular vesicles (EVs) in vascular calcification is currently unknown. Here, we investigated the association of GRP (Gla-rich protein) with circulating CPP and EVs and the role of CKD CPPs and EVs in vascular calcification...
January 4, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29301789/consideration-of-sex-differences-in-design-and-reporting-of-experimental-arterial-pathology-studies-statement-from-atvb-council
#7
REVIEW
Peggy Robinet, Dianna M Milewicz, Lisa A Cassis, Nicholas J Leeper, Hong S Lu, Jonathan D Smith
There are many differences in arterial diseases between men and women, including prevalence, clinical manifestations, treatments, and prognosis. The new policy of the National Institutes of Health, which requires the inclusion of sex as a biological variable for preclinical studies, aims to foster new mechanistic insights and to enhance our understanding of sex differences in human diseases. The purpose of this statement is to suggest guidelines for designing and reporting sex as a biological variable in animal models of atherosclerosis, thoracic and abdominal aortic aneurysms, and peripheral arterial disease...
January 4, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29301788/cardiac-endothelial-cell-transcriptome
#8
Achim Lother, Stella Bergemann, Lisa Deng, Martin Moser, Christoph Bode, Lutz Hein
OBJECTIVE: Endothelial cells (ECs) are a highly specialized cell type with marked diversity between different organs or vascular beds. Cardiac ECs are an important player in cardiac physiology and pathophysiology but are not sufficiently characterized yet. Thus, the aim of the present study was to analyze the cardiac EC transcriptome. APPROACH AND RESULTS: We applied fluorescence-assisted cell sorting to isolate pure ECs from adult mouse hearts. RNAseq revealed 1288 genes predominantly expressed in cardiac ECs versus heart tissue including several transcription factors...
January 4, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29301787/akt2-stabilizes-atp7a-a-copper-transporter-for-sod3-extracellular-superoxide-dismutase-in-vascular-smooth-muscles-novel-mechanism-to-limit-endothelial-dysfunction-in-type-2-diabetes-mellitus
#9
Varadarajan Sudhahar, Mustafa Nazir Okur, Zsolt Bagi, John P O'Bryan, Nissim Hay, Ayako Makino, Vijay S Patel, Shane A Phillips, David Stepp, Masuko Ushio-Fukai, Tohru Fukai
OBJECTIVE: Copper transporter ATP7A (copper-transporting/exporting ATPase) is required for full activation of SOD3 (extracellular superoxide dismutase), which is secreted from vascular smooth muscle cells (VSMCs) and anchors to endothelial cell surface to preserve endothelial function by scavenging extracellular superoxide. We reported that ATP7A protein expression and SOD3 activity are decreased in insulin-deficient type 1 diabetes mellitus vessels, thereby, inducing superoxide-mediated endothelial dysfunction, which are rescued by insulin treatment...
January 4, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29301786/endogenous-line-1-long-interspersed-nuclear-element-1-reverse-transcriptase-activity-in-platelets-controls-translational-events-through-rna-dna-hybrids
#10
Hansjörg Schwertz, Jesse W Rowley, Gerald G Schumann, Ulrike Thorack, Robert A Campbell, Bhanu Kanth Manne, Guy A Zimmerman, Andrew S Weyrich, Matthew T Rondina
OBJECTIVE: One source of endogenous reverse transcriptase (eRT) activity in nucleated cells is the LINE-1/L1 (long interspersed nuclear element-1), a non-LTR retrotransposon that is implicated in the regulation of gene expression. Nevertheless, the presence and function of eRT activity and LINE-1 in human platelets, an anucleate cell, has not previously been determined. APPROACH AND RESULTS: We demonstrate that human and murine platelets possess robust eRT activity and identify the source as being LINE-1 ribonucleoprotein particles...
January 4, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29301785/lp-a-lipoprotein-a-levels-predict-progression-of-carotid-atherosclerosis-in-subjects-with-atherosclerotic-cardiovascular-disease-on-intensive-lipid-therapy-an-analysis-of-the-aim-high-atherothrombosis-intervention-in-metabolic-syndrome-with-low-hdl-high-triglycerides
#11
Daniel S Hippe, Binh An P Phan, Jie Sun, Daniel A Isquith, Kevin O'Brien, John R Crouse, Todd Anderson, John Huston, Santica M Marcovina, Thomas S Hatsukami, Chun Yuan, Xue-Qiao Zhao
OBJECTIVE: To assess whether Lp(a) (lipoprotein(a)) levels and other lipid levels were predictive of progression of atherosclerosis burden as assessed by carotid magnetic resonance imaging in subjects who have been treated with LDL-C (low-density lipoprotein cholesterol)-lowering therapy and participated in the AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes). APPROACH AND RESULTS: AIM-HIGH was a randomized, double-blind study of subjects with established vascular disease, elevated triglycerides, and low HDL-C (high-density lipoprotein cholesterol)...
January 4, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29301784/trpv4-transient-receptor-potential-vanilloid-4-channel-dependent-negative-feedback-mechanism-regulates-gq-protein-coupled-receptor-induced-vasoconstriction
#12
Kwangseok Hong, Eric L Cope, Leon J DeLalio, Corina Marziano, Brant E Isakson, Swapnil K Sonkusare
OBJECTIVE: Several physiological stimuli activate smooth muscle cell (SMC) GqPCRs (Gq protein-coupled receptors) to cause vasoconstriction. As a protective mechanism against excessive vasoconstriction, SMC GqPCR stimulation invokes endothelial cell vasodilatory signaling. Whether Ca2+ influx in endothelial cells contributes to the regulation of GqPCR-induced vasoconstriction remains unknown. Ca2+ influx through TRPV4 (transient receptor potential vanilloid 4) channels is a key regulator of endothelium-dependent vasodilation...
January 4, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29284609/dkk3-dickkopf-3-alters-atherosclerotic-plaque-phenotype-involving-vascular-progenitor-and-fibroblast-differentiation-into-smooth-muscle-cells
#13
Eirini Karamariti, Chungang Zhai, Baoqi Yu, Qiao Lei, Zhihong Wang, Claire M F Potter, Mei Mei Wong, Russell M L Simpson, Zhongyi Zhang, Xiaocong Wang, Ivan Del Barco Barrantes, Christof Niehrs, Deling Kong, Qiang Zhao, Yun Zhang, Yanhua Hu, Cheng Zhang, Qingbo Xu
OBJECTIVES: DKK3 (dickkopf 3), a 36-kD secreted glycoprotein, has been shown to be involved in the differentiation of partially reprogrammed cells and embryonic stem cells to smooth muscle cells (SMCs), but little is known about its involvement in vascular disease. This study aims to assess the effects of DKK3 on atherosclerotic plaque composition. APPROACH AND RESULTS: In the present study, we used a murine model of atherosclerosis (ApoE-/-) in conjunction with DKK3-/- and performed tandem stenosis of the carotid artery to evaluate atherosclerotic plaque development...
December 28, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29284608/melanocortin-1-receptor-deficiency-promotes-atherosclerosis-in-apolipoprotein-e-mice
#14
Petteri Rinne, James J Kadiri, Mauricio Velasco-Delgado, Salla Nuutinen, Miro Viitala, Maija Hollmén, Martina Rami, Eriika Savontaus, Sabine Steffens
OBJECTIVE: The MC1-R (melanocortin 1 receptor) is expressed by monocytes and macrophages where it mediates anti-inflammatory actions. MC1-R also protects against macrophage foam cell formation primarily by promoting cholesterol efflux through the ABCA1 (ATP-binding cassette transporter subfamily A member 1) and ABCG1 (ATP-binding cassette transporter subfamily G member 1). In this study, we aimed to investigate whether global deficiency in MC1-R signaling affects the development of atherosclerosis...
December 28, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29284607/weight-loss-and-exercise-alter-the-high-density-lipoprotein-lipidome-and-improve-high-density-lipoprotein-functionality-in-metabolic-syndrome
#15
Anmar A Khan, Piyushkumar A Mundra, Nora E Straznicky, Paul J Nestel, Gerard Wong, Ricardo Tan, Kevin Huynh, Theodore W Ng, Natalie A Mellett, Jacquelyn M Weir, Christopher K Barlow, Zahir H Alshehry, Gavin W Lambert, Bronwyn A Kingwell, Peter J Meikle
OBJECTIVE: High-density lipoprotein (HDL) lipid composition and function may better reflect cardiovascular risk than HDL cholesterol concentration. This study characterized the relationships between HDL composition, metabolism, and function in metabolic syndrome (MetS) patients and how changes in composition after weight loss (WL) and exercise treatments are related to function. APPROACH AND RESULTS: Plasma samples from MetS patients (n=95) and healthy individuals (n=40) were used in this study...
December 28, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29284606/growth-differentiation-factor-6-promotes-vascular-stability-by-restraining-vascular-endothelial-growth-factor-signaling
#16
Shlomo Krispin, Amber N Stratman, Chase H Melick, Radu V Stan, Matteo Malinverno, Jamie Gleklen, Daniel Castranova, Elisabetta Dejana, Brant M Weinstein
OBJECTIVE: The assembly of a functional vascular system requires a coordinated and dynamic transition from activation to maturation. High vascular endothelial growth factor activity promotes activation, including junction destabilization and cell motility. Maturation involves junctional stabilization and formation of a functional endothelial barrier. The identity and mechanism of action of prostabilization signals are still mostly unknown. Bone morphogenetic protein receptors and their ligands have important functions during embryonic vessel assembly and maturation...
December 28, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29284605/filamin-a-modulates-store-operated-ca2-entry-by-regulating-stim1-stromal-interaction-molecule-1-orai1-association-in-human-platelets
#17
Jose J Lopez, Letizia Albarrán, Isaac Jardín, Jose Sanchez-Collado, Pedro C Redondo, Nuria Bermejo, Regis Bobe, Tarik Smani, Juan A Rosado
OBJECTIVE: Here, we provide evidence for the role of FLNA (filamin A) in the modulation of store-operated calcium entry (SOCE). APPROACH AND RESULTS: SOCE is a major mechanism for calcium influx controlled by the intracellular Ca2+ stores. On store depletion, the endoplasmic reticulum calcium sensor STIM1 (stromal interaction molecule 1) redistributes into puncta at endoplasmic reticulum/plasma membrane junctions, a process supported by the cytoskeleton, where it interacts with the calcium channels; however, the mechanism for fine-tuning SOCE is not completely understood...
December 28, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29284604/homozygous-familial-hypercholesterolemia-patients-with-identical-mutations-variably-express-the-ldlr-low-density-lipoprotein-receptor-implications-for-the-efficacy-of-evolocumab
#18
Aurélie Thedrez, Dirk J Blom, Stéphane Ramin-Mangata, Valentin Blanchard, Mikaël Croyal, Kevin Chemello, Brice Nativel, Matthieu Pichelin, Bertrand Cariou, Steeve Bourane, Lihua Tang, Michel Farnier, Frederick J Raal, Gilles Lambert
OBJECTIVE: Evolocumab, a PCSK9 (proprotein convertase subtilisin kexin type 9)-neutralizing antibody, lowers low-density lipoprotein cholesterol (LDL-C) in homozygous familial hypercholesterolemic (HoFH) patients with reduced LDLR (low-density lipoprotein receptor) function. However, their individual responses are highly variable, even among carriers of identical LDLR genetic defects. We aimed to elucidate why HoFH patients variably respond to PCSK9 inhibition. APPROACH AND RESULTS: Lymphocytes were isolated from 22 HoFH patients enrolled in the TAUSSIG trial...
December 28, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29269515/sex-differences-in-hemodynamic-and-microvascular-mechanisms-of-myocardial-ischemia-induced-by-mental-stress
#19
Samaah Sullivan, Muhammad Hammadah, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ayman Alkhoder, Nino Isakadze, Amit Shah, Oleksiy Levantsevych, Pratik M Pimple, Michael Kutner, Laura Ward, Ernest V Garcia, Jonathon Nye, Puja K Mehta, Tené T Lewis, J Douglas Bremner, Paolo Raggi, Arshed A Quyyumi, Viola Vaccarino
OBJECTIVE: To investigate sex-specific vascular mechanisms for mental stress-induced myocardial ischemia (MSIMI). APPROACH AND RESULTS: Baseline data from a prospective cohort study of 678 patients with coronary artery disease underwent myocardial perfusion imaging before and during a public speaking stressor. The rate-pressure product response was calculated as the difference between the maximum value during the speech minus the minimum value during rest. Peripheral vasoconstriction by peripheral arterial tonometry was calculated as the ratio of pulse wave amplitude during the speech over the resting baseline; ratios <1 indicate a vasoconstrictive response...
December 21, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29269514/2017-scientific-sessions-sol-sherry-distinguished-lecture-in-thrombosis-factor-xi-as-a-target-for-new-anticoagulants
#20
REVIEW
Jeffrey I Weitz, James C Fredenburgh
The goal of anticoagulant therapy is to attenuate thrombosis without compromising hemostasis. Although the direct oral anticoagulants are associated with less intracranial hemorrhage than vitamin K antagonists, bleeding remains their major side effect. Factor XI has emerged as a promising target for anticoagulants that may be safer than those currently available. The focus on factor XI stems from epidemiological evidence of its role in thrombosis, the observation of attenuated thrombosis in factor XI-deficient mice, identification of novel activators, and the fact that factor XI deficiency is associated with only a mild bleeding diathesis...
December 21, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
journal
journal
20047
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"