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Archives of Disease in Childhood. Fetal and Neonatal Edition

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https://www.readbyqxmd.com/read/30425116/premature-small-for-gestational-age-infants-fed-an-exclusive-human-milk-based-diet-achieve-catch-up-growth-without-metabolic-consequences-at-2-years-of-age
#1
Chonnikant Visuthranukul, Steven A Abrams, Keli M Hawthorne, Joseph L Hagan, Amy B Hair
OBJECTIVE: To compare postdischarge growth, adiposity and metabolic outcomes of appropriate for gestational age (AGA) versus small for gestational age (SGA) premature infants fed an exclusive human milk (HM)-based diet in the neonatal intensive care unit. DESIGN: Premature infants (birth weight ≤1250 g) fed an exclusive HM-based diet were examined at 12-15 months corrected gestational age (CGA) (visit 1) for anthropometrics, serum glucose and non-fasting insulin, and at 18-22 months CGA (visit 2) for body composition by dual-energy X-ray absorptiometry...
November 13, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30425115/network-meta-analysis-explained
#2
EDITORIAL
Sofia Dias, Deborah M Caldwell
No abstract text is available yet for this article.
November 13, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30425114/randomised-study-comparing-heart-rate-measurement-in-newly-born-infants-using-a-monitor-incorporating-electrocardiogram-and-pulse-oximeter-versus-pulse-oximeter-alone
#3
Madeleine C Murphy, Laura De Angelis, Lisa K McCarthy, Colm Patrick Finbarr O'Donnell
AIM: To determine whether IntelliVue (ECG plus Masimo pulse oximeter (PO)) measures heart rate (HR) in low-risk newborns more quickly than Nellcor PO (PO alone). METHODS: Unmasked parallel group randomised (1:1) study. RESULTS: We studied 100 infants, 47 randomised to IntelliVue, 53 to Nellcor. Time to first HR was shorter with IntelliVue ECG than Nellcor (median (IQR) 24 (19, 39) vs 48 (36, 69) s, p<0.001). There was no difference in time to display both HR and SpO2 (52 (47, 76) vs 48 (36, 69) s, p=0...
November 13, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30425113/therapeutic-hypothermia-initiated-within-6-hours-of-birth-is-associated-with-reduced-brain-injury-on-mr-biomarkers-in-mild-hypoxic-ischaemic-encephalopathy-a-non-randomised-cohort-study
#4
Paolo Montaldo, Peter J Lally, Vânia Oliveira, Ravi Swamy, Josephine Mendoza, Gaurav Atreja, Ujwal Kariholu, Vijayakumar Shivamurthappa, Natasha Liow, Justinas Teiserskas, Russell Pryce, Aung Soe, Seetha Shankaran, Sudhin Thayyil
OBJECTIVE: To examine the effect of therapeutic hypothermia on MR biomarkers and neurodevelopmental outcomes in babies with mild hypoxic-ischaemic encephalopathy (HIE). DESIGN: Non-randomised cohort study. SETTING: Eight tertiary neonatal units in the UK and the USA. PATIENTS: 47 babies with mild HIE on NICHD neurological examination performed within 6 hours after birth. INTERVENTIONS: Whole-body cooling for 72 hours (n=32) or usual care (n=15; of these 5 were cooled for <12 hours)...
November 13, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30425112/epidemiology-and-healthcare-factors-associated-with-neonatal-enterococcal-infections
#5
Joanna Wang, Christina Kortsalioudaki, Paul T Heath, Jim Buttery, Paul Clarke, Despoina Gkentzi, Mark Anthony, Kenneth Tan
OBJECTIVE: To investigate the epidemiology and healthcare factors associated with late-onset neonatal enterococcal infections. DESIGN: Multicentre, multinational retrospective cohort study using prospectively collected infection data from a neonatal infection surveillance network between 2004 and 2016; this was supplemented with healthcare data from a questionnaire distributed to participating neonatal units. SETTING: Sixty neonatal units across Europe (UK, Greece, Estonia) and Australia...
November 13, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30425111/continuous-glucose-monitoring-in-the-neonatal-intensive-care-unit-not-quite-ready-for-plug-and-play
#6
EDITORIAL
Teri L Hernandez, William W Hay, Paul Joseph Rozance
No abstract text is available yet for this article.
November 13, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30425110/challenges-and-opportunities-for-antibiotic-stewardship-among-preterm-infants
#7
REVIEW
Sagori Mukhopadhyay, Shaon Sengupta, Karen M Puopolo
Antibiotic stewardship programmes aim to optimise antimicrobial use to prevent the emergence of resistance species and protect patients from the side effects of unnecessary medication. The high incidence of systemic infection and associated mortality from these infections leads neonatal providers to frequently initiate antibiotic therapy and make empiric antibiotic courses one of the main contributors of antibiotic use in the neonatal units. Yet, premature infants are also at risk for acute life-threatening complications associated with antibiotic use such as necrotising enterocolitis and for long-term morbidities such as asthma...
November 13, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30385514/cerebral-autoregulation-in-premature-infants-during-the-first-96-hours-of-life-and-relationship-to-adverse-outcomes
#8
Suma B Hoffman, Yun-Ju Cheng, Laurence S Magder, Narendra Shet, Rose M Viscardi
OBJECTIVE: To test the hypothesis that impaired cerebral autoregulation (ICA) increases the susceptibility of premature infants to adverse outcomes, we determined the relationship of ICA and cerebral reactivity (CR) measured in the first 96 hours of life to the outcome of grade 3 or 4 intraventricular haemorrhage (IVH) and/or death within 1 month. SETTING: Single-centre level IV neonatal intensive care unit. PATIENTS: Neonates 24-29 weeks' gestation less than 12 hours old with invasive blood pressure monitoring...
November 1, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30385513/point-of-care-measurements-of-blood-ketones-in-newborns
#9
Deborah L Harris, Philip J Weston, Jane E Harding
OBJECTIVE: Babies may use alternative cerebral fuels including ketones when blood glucose concentrations are low, but laboratory ketone measurements are slow and expensive. Point-of-care measurement of ketone concentrations, if sufficiently accurate, may provide useful information for clinical care. PATIENTS AND DESIGN: Eligible babies were 35-42 weeks' gestation, ≤10 days old and admitted to the newborn intensive care unit. At the time of clinically indicated blood tests, additional samples were taken to measure beta-hydroxybutyrate using a point-of-care analyser and the laboratory method...
November 1, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30355782/uk-neonatal-resuscitation-survey
#10
Elinor Charles, Katie Hunt, Vadivelam Murthy, Christopher Harris, Anne Greenough
BACKGROUND: Previous surveys have demonstrated that neonatal resuscitation practices on the delivery suite vary between UK units, particularly according to the hospital's neonatal unit's level. Our aim was to determine if recent changes to the Resuscitation Council guidelines had influenced clinical practice. METHODS: Surveys of resuscitation practices at UK delivery units carried out in 2012 and 2017 were compared. RESULTS: Comparing 2017 with 2012, initial resuscitation using air was more commonly used in both term (98% vs 75%, p<0...
October 24, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30355781/cerebrovascular-autoregulation-in-preterm-fetal-growth-restricted-neonates
#11
Emily Cohen, Willem Baerts, Alexander Caicedo Dorado, Gunnar Naulaers, Frank van Bel, Petra M A Lemmers
OBJECTIVE: To investigate the effect of fetal growth restriction (FGR) on cerebrovascular autoregulation in preterm neonates during the first 3 days of life. DESIGN: Case-control study. SETTING: Neonatal intensive care unit of the Wilhelmina Children's Hospital, The Netherlands. PATIENTS: 57 FGR (birth weight <10th percentile) and 57 appropriate for gestational age (AGA) (birth weight 20th-80th percentiles) preterm neonates, matched for gender, gestational age, respiratory and blood pressure support...
October 24, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30355780/beta-blocker-therapy-in-recipients-of-twin-to-twin-transfusion-syndrome
#12
Kerstin Gruendler, Christoph E Schwarz, Laila Lorenz, Christian F Poets, Axel R Franz
Recipients of severe twin-to-twin transfusion syndrome (TTTS) may suffer from low cardiac output caused by myocardial hypertrophy and sudden postnatal drop in preload. Our hypothesis was that selective beta-1 adrenergic blockers improve cardiac function in TTTS recipients with left ventricular outflow tract obstruction. We analysed data from two TTTS recipients treated with esmolol/metoprolol. Despite intense circulatory support, both patients showed severe hypotension and tachycardia before therapy. Echocardiographic findings included hypertrophic ventricles with thickened intraventricular septum, reduced aortic valve velocity time integral (AV-VTI), left ventricular outflow tract obstruction and collapsing ventricles in systole...
October 24, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30355779/assessment-of-neonatal-heart-rate-immediately-after-birth-using-digital-stethoscope-handheld-ultrasound-and-electrocardiography-an-observational-cohort-study
#13
Bryony P Treston, Jana Semberova, Robert Kernan, Erica Crothers, Aoife Branagan, Niamh O'Cathain, Jan Miletin
No abstract text is available yet for this article.
October 24, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30355778/it-is-time-to-standardise-the-length-of-postnatal-antibiotic-administration-nationally
#14
Michael Malley, Marnie Bruce, Hannah Devlin, Harsita Patel, Dheeraj Narendra, Seth Cox, Ravi Chotalia
No abstract text is available yet for this article.
October 24, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30337333/newborn-self-inflating-manual-resuscitators-precision-robotic-testing-of-safety-and-reliability
#15
Mark B Tracy, Robert Halliday, Sally K Tracy, Murray K Hinder
AIM: A controlled bench test was undertaken to determine the performance variability among a range of neonatal self-inflating bags (SIB) compliant with current International Standards Organisation (ISO). INTRODUCTION: Use of SIB to provide positive pressure ventilation during newborn resuscitation is a common emergency procedure. The United Nations programmes advocate increasing availability of SIB in low-income and middle-income nations and recommend devices compliant with ISO...
October 18, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30322975/proton-magnetic-resonance-spectroscopy-lactate-n-acetylaspartate-within-2-weeks-of-birth-accurately-predicts-2-year-motor-cognitive-and-language-outcomes-in-neonatal-encephalopathy-after-therapeutic-hypothermia
#16
Subhabrata Mitra, Giles S Kendall, Alan Bainbridge, Magdalena Sokolska, Mary Dinan, Cristina Uria-Avellanal, David Price, Katie Mckinnon, Roxana Gunny, Angela Huertas-Ceballos, Xavier Golay, Nicola J Robertson
OBJECTIVE: Brain proton (1 H) magnetic resonance spectroscopy (MRS) lactate/N-acetylaspartate (Lac/NAA) peak area ratio is used for prognostication in neonatal encephalopathy (NE). At 3 Tesla in NE babies, the objectives were to assess: (1) sensitivity and specificity of basal ganglia and thalamus (BGT) 1 H MRS Lac/NAA for the prediction of Bayley III outcomes at 2 years using optimised metabolite fitting (Tarquin) with threonine and total NAA; (2) prediction of motor outcome with diffusion-weighted MRI; (3) BGT Lac/NAA correlation with the National Institute of Child Health and Human Development (NICHD) MRI score...
October 15, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30322974/optimising-nutrition-during-therapeutic-hypothermia
#17
EDITORIAL
Shalini Ojha, Jon Dorling, Cheryl Battersby, Nicholas Longford, Chris Gale
No abstract text is available yet for this article.
October 15, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30322973/continuous-infusion-versus-intermittent-bolus-doses-of-fentanyl-for-analgesia-and-sedation-in-neonates-an-open-label-randomised-controlled-trial
#18
Thangaraj Abiramalatha, Sumith Koshy Mathew, Binu Susan Mathew, Machilakath Panangandi Shabeer, Geethanjali Arulappan, Manish Kumar, Visalakshi Jayaseelan, Kurien Anil Kuruvilla
OBJECTIVE: Adequate data on fentanyl pharmacokinetics in neonates are lacking. The study was performed to compare serum concentrations and clinical outcome between continuous infusion (CI) and intermittent bolus (IB) doses of fentanyl for analgesia and sedation in neonates. METHODS: In this open-label randomised controlled trial, neonates requiring 24-48 hours of mechanical ventilation and fentanyl administration were recruited. In CI regimen, 1 mcg/kg loading dose was followed by 1 mcg/kg/hour infusion...
October 15, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30314974/is-preterm-nutrition-a-trade-off-between-head-and-heart
#19
EDITORIAL
Gopi Menon, Angela L Davidson, Amanda Jane Drake, Nicholas D Embleton
No abstract text is available yet for this article.
October 12, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30297334/risk-adjusted-mortality-of-vlbw-infants-in-high-volume-versus-low-volume-nicus
#20
Roland Hentschel, Kilian Guenther, Werner Vach, Ingo Bruder
OBJECTIVE: To examine whether the number of very low birthweight (VLBW) infants treated annually in neonatal intensive care units (NICUs) (hospital volume) has an effect on their in-hospital mortality under the regulatory conditions in Germany. SETTING: The study included VLBW infants with <33 weeks of gestational age and birth weight below 1500 g admitted to NICUs in the state of Baden-Wüerttemberg, Germany, from 2003 to 2008. Cases were extracted from the compulsory German neonatal quality assurance programme with variables essential for calculation of the Clinical Risk Index for Babies (CRIB) and PREM birth model (PREM(bm)) scores...
October 8, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
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