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Archives of Disease in Childhood. Fetal and Neonatal Edition

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https://www.readbyqxmd.com/read/30232094/targeting-glucose-control-in-preterm-infants-pilot-studies-of-continuous-glucose-monitoring
#1
Lynn Thomson, Daniela Elleri, Simon Bond, James Howlett, David B Dunger, Kathryn Beardsall
OBJECTIVE: Hyperglycaemia is common in very preterm infants and is associated with adverse outcomes. Preventing hyperglycaemia without increasing the risk of hypoglycaemia is difficult. Real time tracking with continuous glucose monitors (CGM) may improve glucose control. We assessed the feasibility and safety of CGM to target glucose control in preterm infants, to inform a randomised controlled trial (RCT). DESIGN: We performed a single centre study in very preterm infants during the first week of life...
September 19, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30232093/3d-airway-model-to-assess-airway-dead-space
#2
Ashley Nieves, Ashley Cozzo, Zora Kosoff, Chani Traube, Alan M Groves
High flow therapy works partly by washout of airway dead space, the volume of which has not been quantified in newborns. This observational study aimed to quantify airway dead space in infants and to compare efficacy of washout between high flow devices in three-dimensional (3D) printed airway models of infants weighing 2.5-3.8 kg. Nasopharyngeal airway dead space volume was 1.5-2.0 mL/kg in newborns. A single cannula device produced lower carbon dioxide (CO2 ) levels than a dual cannula device (33.7, 31...
September 19, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30217870/high-frequency-oscillatory-ventilation-with-volume-guarantee-a-single-centre-experience
#3
Gusztav Belteki, Colin J Morley
OBJECTIVE: High-frequency oscillatory ventilation (HFOV) is widely used in neonatology. The Dräger Babylog VN500 ventilator offers volume-guaranteed HFOV (HFOV-VG) mode when the high-frequency tidal volume (VThf) to be delivered can be set. We investigated how HFOV-VG maintains VThf in the short and longer term and how it affects other ventilator parameters and blood gases. METHODS: We downloaded ~3.2 million seconds (36.7 days) of ventilator data from 17 infants ventilated using HFOV-VG during clinical care with 1 Hz sampling rate...
September 14, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30194071/evidence-that-therapeutic-hypothermia-should-be-continued-for-72-hours
#4
Joanne O Davidson, Malcolm Battin, Alistair J Gunn
No abstract text is available yet for this article.
September 7, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30158118/ischaemic-limb-lesion-in-monochorionic-twin-infant
#5
Liaqat Hayat Khan, Shabih Manzar
No abstract text is available yet for this article.
August 29, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30154236/effects-of-a-new-device-for-automated-closed-loop-control-of-inspired-oxygen-concentration-on-fluctuations-of-arterial-and-different-regional-organ-tissue-oxygen-saturations-in-preterm-infants
#6
Marek Gajdos, Markus Waitz, Marc Robin Mendler, Wolfgang Braun, Helmut Hummler
OBJECTIVE: To assess the efficacy of a newly developed system for closed loop control of the fraction of inspired oxygen (FiO2 ) on variation of arterial (SpO2 ) and on regional tissue oxygen saturation (StO2 ) in preterm infants with fluctuations in SpO2 . DESIGN: Randomised crossover trial comparing automated (auto) to manual FiO2 adjustment (manual) during two consecutive 24 hours periods using a Sophie infant ventilator (SPO2 C). SETTING: Tertiary university medical centre...
August 28, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30135111/early-postnatal-growth-failure-in-preterm-infants-is-not-inevitable
#7
Edward Thomas Andrews, James John Ashton, Freya Pearson, R Mark Beattie, Mark John Johnson
BACKGROUND: Previously published data have demonstrated that preterm infants experience a fall across marked centile lines for weight in early life with early poor head growth also reported. This study describes a single neonatal unit's experience of longitudinal change in weight, head circumference (HC) and length in a cohort of preterm infants born <32 weeks' gestation. METHODS: Data were collected from a single neonatal unit between July 2012 and June 2017...
August 22, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30097522/perforated-necrotising-enterocolitis-presenting-as-a-rapidly-expanding-abdominal-mass-in-a-preterm-neonate
#8
Caroline Laura Charlesworth, Fauzia Paize, Kate Amy Kewley
No abstract text is available yet for this article.
August 10, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30097521/caput-medusa-in-a-newborn-infant
#9
Michal Molad, Karen Lavie-Nevo, Corina Hartman
No abstract text is available yet for this article.
August 10, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30068670/how-should-we-chart-the-growth-of-very-preterm-babies
#10
EDITORIAL
Freya Pearson, Mark John Johnson
No abstract text is available yet for this article.
August 1, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30068669/sedation-during-minimal-invasive-surfactant-therapy-a-randomised-controlled-trial
#11
Janneke Dekker, Enrico Lopriore, Henriëtte A van Zanten, Ratna N G B Tan, Stuart B Hooper, Arjan B Te Pas
BACKGROUND AND AIMS: Although sedation for endotracheal intubation of infants is widely adopted, there is no consensus whether sedation should be used for minimal invasive surfactant therapy (MIST). We compared, in a randomised controlled setting, the level of stress and comfort of preterm infants during MIST with and without receiving low-dose sedation. METHODS: Infants between 26 and 36 weeks gestational age were randomised to receive either low-dose sedation (1 mg/kg propofol intravenous) or no premedication during MIST procedure...
August 1, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30068668/volume-targeted-ventilation-one-size-does-not-fit-all-evidence-based-recommendations-for-successful-use
#12
REVIEW
Martin Keszler
Despite level 1 evidence for important benefits of volume-targeted ventilation (VTV), many vulnerable extremely preterm infants continue to be exposed to traditional pressure-controlled ventilation. Lack of suitable equipment and a lack of appreciation of the fact that 'one size does NOT fit all' appear to contribute to the slow uptake of VTV. This review attempts to improve clinicians' understanding of the way VTV works and to provide essential information about evidence-based tidal volume (VT ) targets. Focus on underlying lung pathophysiology, individualised ventilator settings and VT targets are keys to successful use of VTV thereby improving important clinical outcomes...
August 1, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30049729/nebulised-surfactant-to-reduce-severity-of-respiratory-distress-a-blinded-parallel-randomised-controlled-trial
#13
Stefan Minocchieri, Clare A Berry, J Jane Pillow
OBJECTIVE: To evaluate if nebulised surfactant reduces intubation requirement in preterm infants with respiratory distress treated with nasal continuous positive airway pressure (nCPAP). DESIGN: Double blind, parallel, stratified, randomised control trial. SETTING: Sole tertiary neonatal unit in West Australia. PATIENTS: Preterm infants (290 -336  weeks' gestational age, GA) less than 4 hours of age requiring 22%-30% supplemental oxygen, with informed parental written consent...
July 26, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30049728/m%C3%A3-bius-sequence-with-central-hypoventilation-in-a-neonate-after-failed-elective-medical-termination-of-pregnancy
#14
Fahim Patel, Jonathan Cusack
No abstract text is available yet for this article.
July 26, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30049727/supporting-breathing-of-preterm-infants-at-birth-a-narrative-review
#15
REVIEW
Tessa Martherus, André Oberthuer, Janneke Dekker, Stuart B Hooper, Erin V McGillick, Angela Kribs, Arjan B Te Pas
Most very preterm infants have difficulty aerating their lungs and require respiratory support at birth. Currently in clinical practice, non-invasive ventilation in the form of continuous positive airway pressure (CPAP) and positive pressure ventilation (PPV) is applied via facemask. As most very preterm infants breathe weakly and unnoticed at birth, PPV is often administered. PPV is, however, frequently ineffective due to pressure settings, mask leak and airway obstruction. Meanwhile, high positive inspiratory pressures and spontaneous breathing coinciding with inflations can generate high tidal volumes...
July 26, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30049726/postnatal-cardiovascular-adaptation
#16
REVIEW
Andrew William Gill
The heart undergoes rapid transformations in function during the transition to extrauterine life. Our understanding of the adaptive physiology underlying this process is able to inform the clinical management of infants who are struggling to complete this complex transition. Much of our knowledge of the cardiac transition is derived from the preterm infant in whom the preparative adaptations are incomplete and clinical sequelae all too common. This review will re-examine the cardiac transition highlighting the physiology that drives it and suggest appropriate clinical intervention to support the process...
July 26, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30049725/diagnostic-accuracy-of-imaging-studies-in-congenital-lung-malformations
#17
Rodrigo A Mon, Kevin N Johnson, Maria Ladino-Torres, Amer Heider, George B Mychaliska, Marjorie C Treadwell, Shaun M Kunisaki
BACKGROUND: Although fetal ultrasound, fetal MRI and postnatal CT are now widely used in the evaluation of congenital lung malformations (CLM), their diagnostic accuracy remains undefined. OBJECTIVE: To correlate prenatal and postnatal imaging studies with pathological data after CLM resection. DESIGN: Retrospective, descriptive case series study. SETTING: A North American tertiary care centre. PATIENTS: One hundred and three consecutive lung resections for a suspected CLM between 1 January 2005 and 31 December 2015...
July 26, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30049724/blood-pressure-intervention-levels-in-preterm-infants-pilot-randomised-trial
#18
Sujith Stanley Pereira, Ajay Kumar Sinha, Joan Katherine Morris, David F Wertheim, Divyen K Shah, Stephen Terence Kempley
OBJECTIVE: To examine the feasibility of a trial allocating different blood pressure (BP) intervention levels for treatment in extremely preterm infants. DESIGN: Three-arm open randomised controlled trial performed between February 2013 and April 2015. SETTING: Single tertiary level neonatal intensive care unit. PATIENTS: Infants born <29 weeks' gestation were eligible to participate, if parents consented and they did not have a major congenital malformation...
July 26, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30032105/patient-ventilator-asynchrony-in-preterm-infants-on-nasal-intermittent-positive-pressure-ventilation
#19
Cornelia G de Waal, Ruud W van Leuteren, Frans H de Jongh, Anton H van Kaam, Gerard J Hutten
OBJECTIVE: To describe the incidence of patient-ventilator asynchrony and different types of asynchrony in preterm infants treated with non-synchronised nasal intermittent positive pressure ventilation (nIPPV). DESIGN: An observational study was conducted including preterm infants born with a gestational age (GA) less than 32 weeks treated with non-synchronised nIPPV. During 1 hour, spontaneous breathing was measured with transcutaneous electromyography of the diaphragm simultaneous with ventilator inflations...
July 21, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/30030294/oesophageal-atresia-with-tracheo-oesophageal-fistula-an-unusual-radiological-presentation
#20
Neaha Patel, Rainer Ebel
No abstract text is available yet for this article.
July 20, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
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