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Annals of Surgical Oncology

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https://www.readbyqxmd.com/read/28936799/proteomic-features-of-colorectal-cancer-identify-tumor-subtypes-independent-of-oncogenic-mutations-and-independently-predict-relapse-free-survival
#1
Callisia N Clarke, Michael S Lee, Wei Wei, Ganiraju Manyam, Zhi-Qin Jiang, Yiling Lu, Jeffrey Morris, Bradley Broom, David Menter, Eduardo Vilar-Sanchez, Kanwal Raghav, Cathy Eng, George J Chang, Iris Simon, Rene Bernards, Michael Overman, Gordon B Mills, Dipen Maru, Scott Kopetz
BACKGROUND: The directed study of the functional proteome in colorectal cancer (CRC) has identified critical protein markers and signaling pathways; however, the prognostic relevance of many of these proteins remains unclear. METHODS: We determined the prognostic implications of the functional proteome in 263 CRC tumor samples from patients treated at MD Anderson Cancer Center (MDACC) and 462 patients from The Cancer Genome Atlas (TCGA) to identify patterns of protein expression that drive tumorigenesis...
September 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28933054/high-stmn1-expression-is-associated-with-cancer-progression-and-chemo-resistance-in-lung-squamous-cell-carcinoma
#2
Pinjie Bao, Takehiko Yokobori, Bolag Altan, Misaki Iijima, Youko Azuma, Ryoichi Onozato, Toshiki Yajima, Akira Watanabe, Akira Mogi, Kimihiro Shimizu, Toshiteru Nagashima, Yoichi Ohtaki, Kai Obayashi, Seshiru Nakazawa, Tuya Bai, Reika Kawabata-Iwakawa, Takayuki Asao, Kyoichi Kaira, Masahiko Nishiyama, Hiroyuki Kuwano
BACKGROUND: Known as a microtubule-destabilizing protein, STMN1 (gene symbol: STMN1) regulates the dynamics of microtubules, cell cycle progress, and chemo-resistance against taxane agents. It is highly expressed in various human cancers and involved in cancer progression as well as poor prognosis. METHODS: Expression of STMN1 was examined by immunohistochemistry using FFPE tissue sections from 186 patients with lung squamous cell carcinoma (LSCC). Analysis of STMN1 suppression was performed for STMN1 small interfering RNA (siRNA)-transfected LSCC cell lines to determine the change in proliferation, invasive and apoptosis abilities, and paclitaxel sensitivity...
September 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28929463/individualized-treatment-sequencing-selection-contributes-to-optimized-survival-in-patients-with-rectal-cancer-and-synchronous-liver-metastases
#3
Claudius Conrad, Jean-Nicolas Vauthey, Okuno Masayuki, Rahul A Sheth, Suguru Yamashita, Guillaume Passot, Christina E Bailey, Daria Zorzi, Scott Kopetz, Thomas A Aloia, Y Nancy You
BACKGROUND: The optimal treatment sequence for patients with advanced rectal cancer and synchronous resectable liver metastases is controversial. We examined the outcomes associated with an individualized selection of classic, reversed, or combined approaches. METHODS: Between 1999 and 2014, 268 patients with rectal cancer and synchronous liver-only metastases underwent curative-intent multimodality therapy. Demographics and tumor and treatment details were reviewed...
September 19, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28924845/inspection-of-perirectal-lymph-nodes-by-one-step-nucleic-acid-amplification-predicts-lateral-lymph-node-metastasis-in-advanced-rectal-cancer
#4
Yuichiro Miyake, Tsunekazu Mizushima, Taishi Hata, Hidekazu Takahashi, Hiroyuki Hanada, Hiroki Shoji, Masatoshi Nomura, Naotsugu Haraguchi, Junichi Nishimura, Chu Matsuda, Ichiro Takemasa, Yuichiro Doki, Ikuhiro Maeda, Masaki Mori, Hirofumi Yamamoto
BACKGROUND: Lateral lymph node dissection (LLND) is performed for advanced rectal cancers in Japan; however, it can cause sexual and urinary dysfunction. The incidence of lateral LN metastasis is estimated at 7-13.9%; therefore, excessive rectal surgery with LLND should be avoided, especially for prophylactic purposes. To identify the patients who require LLND, we examined metastases in perirectal LNs by using a one-step nucleic acid amplification (OSNA) assay to predict lateral LN metastases...
September 18, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28916978/tumor-biology-predicts-pathologic-complete-response-to-neoadjuvant-chemotherapy-in-patients-presenting-with-locally-advanced-breast-cancer
#5
Lori F Gentile, George Plitas, Emily C Zabor, Michelle Stempel, Monica Morrow, Andrea V Barrio
BACKGROUND: Neoadjuvant chemotherapy (NAC) is used to convert patients with inoperable locally advanced breast cancer (LABC) to operability, but has not traditionally been used to avoid mastectomy or axillary dissection in this subset. OBJECTIVE: The purpose of this study was to determine the rates of pathologic complete response (pCR) in LABC patients, and identify factors predictive of pCR to determine if responding patients might be suitable for limited surgery...
September 15, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28913761/radioactive-seed-localization-versus-wire-guided-localization-for-nonpalpable-breast-cancer-a-cost-and-operating-room-efficiency-analysis
#6
Yimeng Zhang, Jean Seely, Erin Cordeiro, Joshua Hefler, Kednapa Thavorn, Mukta Mahajan, Sue Domina, Jon Aro, Andrea Marie Ibrahim, Angel Arnaout, Denis Gravel, Carolyn Nessim
BACKGROUND: This study aimed to compare the cost and resource use between our first-year experience using breast-conserving surgery (BCS) with radioactive seed localization (RSL) and the previous-year standard practice of BCS with wire-guided localization (WGL) for patients with nonpalpable breast cancer at a large Canadian tertiary center. METHODS: For this retrospective cohort study, data for BCS cases with RSL was collected from 1 April 2015 to 31 March 2016 and for BCS cases with WGL from 1 April 2014 to 31 March 2015...
September 14, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28905248/sexual-function-and-breast-specific-sensuality-remain-important-after-breast-cancer-surgery
#7
EDITORIAL
Sarah A McLaughlin, Lauren F Cornell, Dawn M Mussallem
No abstract text is available yet for this article.
September 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28895113/validation-of-the-8th-edition-of-the-ajcc-tnm-staging-system-for-gastric-cancer-using-the-national-cancer-database
#8
Haejin In, I Solsky, B Palis, M Langdon-Embry, J Ajani, T Sano
BACKGROUND: The 8th edition AJCC gastric cancer staging manual was refined using Japanese and Korean data from the International Gastric Cancer Association (IGCA). This study evaluated the eighth edition's validity for U.S. POPULATIONS: HASH(0x50448c0) METHODS: National Cancer Database (NCDB) was used to obtain data on gastric cancer patients diagnosed from 2004 to 2008 who underwent surgery and to examine differences in stage grouping and survival between AJCC 7th and 8th editions...
September 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28895112/external-validation-of-the-prognostic-nomogram-compass-for-patients-with-peritoneal-carcinomatosis-of-colorectal-cancer
#9
Karel Demey, Albert Wolthuis, Anthony de Buck van Overstraeten, Steffen Fieuws, Vincent Vandecaveye, Eric Van Cutsem, André D'Hoore
BACKGROUND: To optimize outcome, selection of patients for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is critical. Recently, Simkens et al.7 evaluated the peritoneal surface disease severity score (PSDSS) and suggested a new prognostic nomogram, the colorectal peritoneal metastases prognostic surgical score (COMPASS) based on age, peritoneal carcinomatosis index score, locoregional lymph node status, and signet ring cell histology. This COMPASS nomogram had better discriminative ability according to the Harrell c-index than PSDSS (c = 0...
September 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28895107/external-beam-radiation-therapy-for-resectable-soft-tissue-sarcoma-a-systematic-review-and-meta-analysis
#10
Markus Albertsmeier, Alexandra Rauch, Falk Roeder, Sandro Hasenhütl, Sebastian Pratschke, Michaela Kirschneck, Alessandro Gronchi, Nina L Jebsen, Philippe A Cassier, Paul Sargos, Claus Belka, Lars H Lindner, Jens Werner, Martin K Angele
PURPOSE: The aim of this study was to evaluate the role of preoperative and postoperative external beam radiation therapy (EBRT) in the treatment of resectable soft tissue sarcomas (STSs) of different tumor locations. METHODS: A systematic literature search was performed to identify studies investigating the effects of EBRT (versus no EBRT) on local recurrence (LR) and overall survival (OS) or comparing different EBRT sequences. Random effects meta-analyses were calculated and presented as cumulative odds ratios (ORs)...
September 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28895102/the-impact-of-nodal-dissection-on-staging-in-adrenocortical-carcinoma
#11
Suraj Panjwani, Maureen D Moore, Katherine D Gray, Brendan M Finnerty, Toni Beninato, Laurent Brunaud, Thomas J Fahey, Rasa Zarnegar
BACKGROUND: The role of lymphadenectomy in adrenocortical carcinoma (ACC) is controversial, and formal lymph node (LN) dissection is not routine. We sought to determine the minimum number of LNs that must be examined to accurately identify a patient as node negative. METHODS: The National Cancer Database was used to identify patients diagnosed with ACC from 2004 to 2013 who underwent surgical resection. Patients with distant metastases, multivisceral resection, or missing surgical or lymphadenectomy data were excluded...
September 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28895087/benefit-of-adjuvant-radiotherapy-for-local-control-distant-metastasis-and-survival-outcomes-in-patients-with-localized-soft-tissue-sarcoma-comparative-effectiveness-analysis-of-an-observational-cohort-study
#12
Florian Posch, Richard Partl, Carmen Döller, Jakob M Riedl, Maria Smolle, Lukas Leitner, Marko Bergovec, Bernadette Liegl-Atzwanger, Michael Stotz, Angelika Bezan, Armin Gerger, Martin Pichler, Karin S Kapp, Herbert Stöger, Andreas Leithner, Joanna Szkandera
BACKGROUND: This study aimed to quantify the benefit of adjuvant radiotherapy (AXRT) for local control, distant metastasis, and long-term survival outcomes in patients with localized soft tissue sarcoma (STS). METHODS: This single-center retrospective observational study enrolled 433 STS patients who underwent surgery with curative intent. An inverse probability of treatment-weighted (IPTW) analysis was implemented to account rigorously for imbalances in prognostic variables between the adjuvant treatment groups...
September 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28895084/the-oncologic-impact-of-postoperative-complications-following-resection-of-truncal-and-extremity-soft-tissue-sarcomas
#13
Justine S Broecker, Cecilia G Ethun, David K Monson, Alexandra G Lopez-Aguiar, Nina Le, Mia McInnis, Karen Godette, Nickolas B Reimer, Shervin V Oskouei, Keith A Delman, Charles A Staley, Shishir K Maithel, Kenneth Cardona
INTRODUCTION: Postoperative complications (POCs) negatively impact oncologic outcomes in some malignancies; however, little is known regarding their effect in soft tissue sarcoma (STS). The aim of this study was to determine the impact of POCs on survival after resection of truncal and extremity STS. METHODS: All patients who underwent resection for a primary truncal or extremity STS at a single academic institution from 2000 to 2015 were included and analyzed. Primary outcome was disease-specific survival (DSS)...
September 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28887762/evolution-of-the-staging-system-in-breast-cancer
#14
EDITORIAL
Cory A Donovan, Armando E Giuliano
No abstract text is available yet for this article.
September 8, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28887726/long-term-follow-up-of-desmoid-fibromatosis-treated-with-pf-03084014-an-oral-gamma-secretase-inhibitor
#15
Victor Manuel Villalobos, Francis Hall, Antonio Jimeno, Lia Gore, Kenneth Kern, Rossano Cesari, Bo Huang, Jeffrey T Schowinsky, Patrick Judson Blatchford, Brianna Hoffner, Anthony Elias, Wells Messersmith
BACKGROUND: Desmoid fibromatosis is a fibroblastic neoplasm driven by aberrations within the WNT pathway, exhibiting mutations in β-catenin or APC. We review the long-term follow-up of patients in a phase I study treated with an oral gamma secretase inhibitor, PF-03084014. METHODS: PF-03084014 was administered orally at doses ranging from 20 to 330 mg twice daily. Tumor assessments were performed using computed tomography/magnetic resonance imaging (CT/MRI) within 4 weeks of study entry, and every other cycle through cycle 9...
September 8, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28884452/microsurgical-reconstruction-following-oncologic-resection-in-pediatric-patients-a-15-year-experience
#16
Margaret J Starnes-Roubaud, Matthew M Hanasono, Michael E Kupferman, Jun Liu, Edward I Chang
BACKGROUND: Free tissue transfer in the pediatric population is a challenging endeavor, even for experienced microsurgeons. Some surgeons argue these cases can be limited by vessel size and spasticity and should be undertaken only when absolutely necessary. We present a 15-year experience examining outcomes of free tissue transfer in pediatric oncologic patients. METHODS: All free flaps performed at a single institution in pediatric patients (age range 3-17) between January 2000 and December 2014 were reviewed...
September 7, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28884434/clinical-predictors-of-malignancy-in-patients-with-pheochromocytoma-and-paraganglioma
#17
Mashaal Dhir, Wei Li, Melissa E Hogg, David L Bartlett, Sally E Carty, Kelly L McCoy, Sue M Challinor, Linwah Yip
BACKGROUND AND PURPOSE: Factors associated with malignancy in patients with pheochromocytoma (adrenal tumors, Pheo) and paraganglioma (extra-adrenal, PGL) are not well-defined and all patients require lifelong surveillance. The primary aim of our study was to determine genetic and clinical variables associated with malignancy in patients with Pheo/PGL. METHODS: Single institution retrospective review was performed of all patients who underwent surgery (1/95-1/15) for Pheo/PGL...
September 7, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28879416/patient-age-and-tumor-subtype-predict-the-extent-of-axillary-surgery-among-breast-cancer-patients-eligible-for-the-american-college-of-surgeons-oncology-group-trial-z0011
#18
Cecilia T Ong, Samantha M Thomas, Rachel C Blitzblau, Oluwadamilola M Fayanju, Tristen S Park, Jennifer K Plichta, Laura H Rosenberger, Terry Hyslop, E Shelley Hwang, Rachel A Greenup
BACKGROUND: The American College of Surgeons Oncology Group (ACOSOG) Z0011 trial established the safety of omitting axillary lymph node dissection (ALND) for early-stage breast cancer patients with limited nodal disease undergoing lumpectomy. We examined the extent of axillary surgery among women eligible for Z0011 based on patient age and tumor subtype. METHODS: Patients with cT1-2, cN0 breast cancers and one or two positive nodes diagnosed from 2009 to 2014 and treated with lumpectomy were identified in the National Cancer Data Base...
September 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28871564/redefining-the-positive-margin-in-pancreatic-cancer-impact-on-patterns-of-failure-long-term-survival-and-adjuvant-therapy
#19
Arsen Osipov, Nicholas Nissen, Joanne Rutgers, Deepti Dhall, Jason Naziri, Shefali Chopra, Quanlin Li, Andrew Eugene Hendifar, Richard Tuli
PURPOSE: There is debate regarding the definition and clinical significance of margin clearance in pancreatic ductal adenocarcinoma (PDA). A comprehensive archival analysis of surgical resection margins was performed to determine the effect on locoregional recurrence and survival, and the impact of adjuvant therapy in PDA. METHODS: We identified 105 patients with resected PDA. Pancreatic, anterior, bile duct, and posterior surgical resection margins (PM; posterior surface, uncinate and vascular groove) were identified...
September 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28871563/prognostic-value-of-the-age-adjusted-charlson-comorbidity-index-acci-on-short-and-long-term-outcome-in-patients-with-advanced-primary-epithelial-ovarian-cancer
#20
Annett Kahl, Andreas du Bois, Philipp Harter, Sonia Prader, Stephanie Schneider, Florian Heitz, Alexander Traut, Pier Francesco Alesina, Beate Meier, Martin Walz, Annettte Brueckner, Harald-Thomas Groeben, Violeta Brunkhorst, Sebastian Heikaus, Beyhan Ataseven
BACKGROUND: We evaluated the prognostic impact of the age-adjusted Charlson Comorbidity Index (ACCI) on both postoperative morbidity and overall survival (OS) in patients with advanced epithelial ovarian cancer (EOC) treated at a tertiary gynecologic cancer center. PATIENTS AND METHODS: Exploratory analysis of our prospectively documented tumor registry was performed. Data of all consecutive patients with stage IIIB-IV ovarian cancer who underwent primary cytoreductive surgery (PDS) from January 2000 to June 2016 were analyzed...
September 5, 2017: Annals of Surgical Oncology
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