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Annals of Surgical Oncology

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https://www.readbyqxmd.com/read/28229288/complications-in-diep-flap-breast-reconstruction-after-mastectomy-for-breast-cancer-a-prospective-cohort-study-comparing-unilateral-versus-bilateral-reconstructions
#1
Ryckie G Wade, Sergio Razzano, Elaine M Sassoon, Richard M Haywood, Rozina S Ali, Andrea Figus
BACKGROUND: The demand for bilateral breast reconstructions is rising worldwide. In the UK, approximately 30% of breast cancer patients undergoing mastectomy choose autologous tissue breast reconstruction. Although the deep inferior epigastric perforator (DIEP) flap is gaining popularity, bilateral DIEP flap breast reconstruction remains a complex procedure and reliable outcome data are lacking. In the absence of clinical trials, evidence from cohort studies is needed to better inform clinicians and patients...
February 22, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28224367/novel-treatment-with-intraperitoneal-moc31pe-immunotoxin-in-colorectal-peritoneal-metastasis-results-from-the-immunopeca-phase-1-trial
#2
Ida S Frøysnes, Yvonne Andersson, Stein G Larsen, Ben Davidson, Janne-Merete Torset Øien, Kari Hauge Olsen, Karl-Erik Giercksky, Lars Julsrud, Øystein Fodstad, Svein Dueland, Kjersti Flatmark
BACKGROUND: MOC31PE immunotoxin was developed to rapidly kill cells expressing the tumor-associated epithelial cell adhesion molecule, which is highly expressed in colorectal cancer. Although cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may offer long-term survival to patients with peritoneal metastasis from colorectal cancer (PM-CRC), most patients experience disease relapse and novel therapeutic options are needed. On this basis, MOC31PE is being developed as a novel therapeutic principle to target PM-CRC...
February 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28224366/comparison-of-short-term-outcomes-between-open-and-minimally-invasive-esophagectomy-for-esophageal-cancer-using-a-nationwide-database-in-japan
#3
Hiroya Takeuchi, Hiroaki Miyata, Soji Ozawa, Harushi Udagawa, Harushi Osugi, Hisahiro Matsubara, Hiroyuki Konno, Yasuyuki Seto, Yuko Kitagawa
PURPOSE: This study aimed to compare short-term outcomes of minimally invasive esophagectomy (MIE) with those of open esophagectomy (OE) for thoracic esophageal cancer using a nationwide Japanese database. METHODS: Overall, 9584 patients with thoracic esophageal cancer who underwent esophagectomy at 864 hospitals in 2011-2012 were evaluated. We performed one-to-one matching between the MIE and OE groups on the basis of estimated propensity scores for each patient...
February 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28224365/timing-of-surgical-resection-for-curative-colorectal-cancer-with-liver-metastasis
#4
Shahzad M Ali, Timothy M Pawlik, Miguel A Rodriguez-Bigas, John R T Monson, George J Chang, David W Larson
PURPOSE AND DESIGN: Optimal surgical strategy for resectable synchronous colorectal cancer with liver metastasis (SCRLM) remains a therapeutic dilemma. Multiple retrospective studies including several meta-analyses have been published since 2001 to help facilitate the decision making process and identify the optimal surgical approach. Controversy limits the generalization of available data to draw conclusions. A review of available literature on appropriate surgical timing may alleviate confusion among physicians and promote a more evidence based approach...
February 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28224364/the-impact-of-smoking-on-sentinel-node-metastasis-of-primary-cutaneous-melanoma
#5
Maris S Jones, Peter C Jones, Stacey L Stern, David Elashoff, Dave S B Hoon, John Thompson, Nicola Mozzillo, Omgo E Nieweg, Dirk Noyes, Harald J Hoekstra, Jonathan S Zager, Daniel F Roses, Alessandro Testori, Brendon J Coventry, Mark B Smithers, Robert Andtbacka, Doreen Agnese, Erwin Schultz, Eddy C Hsueh, Mark Kelley, Schlomo Schneebaum, Lisa Jacobs, Tawnya Bowles, Mohammed Kashani-Sabet, Douglas Johnson, Mark B Faries
BACKGROUND: Although a well-established causative relationship exists between smoking and several epithelial cancers, the association of smoking with metastatic progression in melanoma is not well studied. We hypothesized that smokers would be at increased risk for melanoma metastasis as assessed by sentinel lymph node (SLN) biopsy. METHODS: Data from the first international Multicenter Selective Lymphadenectomy Trial (MSLT-I) and the screening-phase of the second trial (MSLT-II) were analyzed to determine the association of smoking with clinicopathologic variables and SLN metastasis...
February 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28224363/prognostic-significance-of-sarcopenia-in-patients-with-esophagogastric-junction-cancer-or-upper-gastric-cancer
#6
Kensuke Kudou, Hiroshi Saeki, Yuichiro Nakashima, Keitaro Edahiro, Shotaro Korehisa, Daisuke Taniguchi, Ryosuke Tsutsumi, Sho Nishimura, Yu Nakaji, Shingo Akiyama, Hirotada Tajiri, Ryota Nakanishi, Junji Kurashige, Masahiko Sugiyama, Eiji Oki, Yoshihiko Maehara
BACKGROUND: The association between sarcopenia and postoperative outcomes for patients with gastrointestinal malignancies remains controversial. This study aimed to assess the impact of sarcopenia on short- and long-term outcomes after surgery for esophagogastric junction cancer (EGJC) or upper gastric cancer (UGC). METHODS: The study reviewed 148 patients with EGJC or UGC who underwent surgical resection. The patients were categorized into the sarcopenia group or the non-sarcopenia group according to their skeletal muscle index calculated using abdominal computed tomography images...
February 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28213792/validation-of-the-american-joint-commission-on-cancer-ajcc-8th-edition-staging-system-for-patients-with-pancreatic-adenocarcinoma-a-surveillance-epidemiology-and-end-results-seer-analysis
#7
Sivesh K Kamarajah, William R Burns, Timothy L Frankel, Clifford S Cho, Hari Nathan
BACKGROUND: The 8th edition of the AJCC staging system for pancreatic cancer incorporated several significant changes. This study sought to evaluate this staging system and assess its strengths and weaknesses relative to the 7th edition AJCC staging system. METHODS: Using the Surveillance, Epidemiology and End Results (SEER) database (2004-2013), 8960 patients undergoing surgical resection for non-metastatic pancreatic adenocarcinoma were identified. Overall survival was estimated using the Kaplan-Meier method and compared using log-rank tests...
February 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28213791/tumor-associated-macrophage-infiltration-in-colorectal-cancer-liver-metastases-is-associated-with-better-outcome
#8
Michael J Cavnar, Simon Turcotte, Steven C Katz, Deborah Kuk, Mithat Gönen, Jinru Shia, Peter J Allen, Vinod P Balachandran, Michael I D'Angelica, T Peter Kingham, William R Jarnagin, Ronald P DeMatteo
BACKGROUND: Tumor-associated macrophages (TAMs) support growth in most human cancers, with the notable exception of colorectal adenocarcinoma, in which TAM infiltration of primary tumors is correlated with a better outcome. The importance of TAMs in colorectal liver metastases (CLM) is unknown. METHODS: Using a tissue microarray of CLM resected at their institution from 1998 to 2000, the authors quantified immune marker expression by immunohistochemistry (IHC) using Metamorph Image Analysis software...
February 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28213790/optical-see-through-cancer-vision-goggles-enable-direct-patient-visualization-and-real-time-fluorescence-guided-oncologic-surgery
#9
Suman B Mondal, Shengkui Gao, Nan Zhu, LeMoyne Habimana-Griffin, Walter J Akers, Rongguang Liang, Viktor Gruev, Julie Margenthaler, Samuel Achilefu
BACKGROUND: The inability to visualize the patient and surgical site directly, limits the use of current near infrared fluorescence-guided surgery systems for real-time sentinel lymph node biopsy and tumor margin assessment. METHODS: We evaluated an optical see-through goggle augmented imaging and navigation system (GAINS) for near-infrared, fluorescence-guided surgery. Tumor-bearing mice injected with a near infrared cancer-targeting agent underwent fluorescence-guided, tumor resection...
February 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28213789/a-novel-prognostic-scoring-system-based-on-preoperative-sarcopenia-predicts-the-long-term-outcome-for-patients-after-r0-resection-for-gastric-cancer-experiences-of-a-high-volume-center
#10
Zhi-Fang Zheng, Jun Lu, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Mi Lin, Chang-Ming Huang
BACKGROUND: The relationship between sarcopenia and prognosis of gastric cancer (GC) is unclear. This study aimed to develop a prognostic scoring system combining sarcopenia with preoperative clinical parameters for patients with GC to predict 3-year overall survival (OS) and 3-year recurrence-free survival (RFS). METHODS: In this study, 924 patients with GC who underwent radical gastrectomy were retrospectively analyzed. The data were divided into a training set and a validation set...
February 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28213788/three-different-approaches-to-the-inferior-mesenteric-artery-during-robotic-d3-lymphadenectomy-for-rectal-cancer
#11
Songphol Malakorn, Tarik Sammour, Brian Bednarski, Yi-Qian Nancy You, George J Chang
BACKGROUND: In rectal cancer surgery, proximal ligation of the inferior mesenteric artery (IMA) with radical lymphadenectomy is the accepted standard of care.1 Our purpose is to describe three different standardized technical approaches for the management of the IMA during D3 lymphadenectomy.2 METHODS: Operative videos of three robotic D3 lymphadenectomy procedures for rectal cancer were reviewed and annotated with schematic anatomical descriptions for clarification. RESULTS: There are three methods for the management of the IMA during D3 lymphadenectomy for rectal cancer...
February 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28204963/peritoneal-metastases-from-gastroenteropancreatic-neuroendocrine-tumors-incidence-risk-factors-and-prognosis
#12
Ariana Madani, Irene Thomassen, Yvette R B M van Gestel, Jarmila D W van der Bilt, Harm R Haak, Ignace H J T de Hingh, Valery E P P Lemmens
BACKGROUND: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare neoplasms and data on peritoneal metastases (PM) from these tumors are scarce. OBJECTIVE: The aim of this study was to present population-based data on the incidence, risk factors, and survival of synchronous PM in GEP-NETs. METHODS: Data from all patients diagnosed with a GEP-NET during 2007-2013 were collected from the Netherlands Cancer Registry. Age-standardized incidence rates were calculated and risk factors for developing PM were determined using multivariable logistic regression analysis...
February 15, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28194592/the-yield-of-staging-laparoscopy-in-gastric-cancer-is-affected-by-racial-and-ethnic-differences-in-disease-presentation
#13
Ibrahim Nassour, Hannah Fullington, Linda S Hynan, Adam C Yopp, Mathew M Augustine, Patricio M Polanco, Michael A Choti, John C Mansour, Sam C Wang, Matthew R Porembka
BACKGROUND: Gastric cancer is a heterogeneous disease with variable presentation between racial and ethnic groups. Staging laparoscopy (SL) detects occult metastases not visible on cross-sectional imaging and therefore improves staging. It remains unclear how differences in race and ethnicity affect disease presentation and the yield of SL. METHODS: We performed a retrospective review of a prospectively maintained database to identify patients with gastric cancer treated with curative intent at our institutions from 2008 to 2015...
February 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28194591/complications-in-diep-flap-breast-reconstruction-after-mastectomy-for-breast-cancer-a-prospective-cohort-study-comparing-unilateral-and-bilateral-reconstructions
#14
EDITORIAL
Mark V Schaverien, Charles E Butler
No abstract text is available yet for this article.
February 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28194590/society-of-surgical-oncology-70th-annual-cancer-symposium
#15
(no author information available yet)
No abstract text is available yet for this article.
February 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28188502/efficacy-of-preoperative-portal-vein-embolization-among-patients-with-hepatocellular-carcinoma-biliary-tract-cancer-and-colorectal-liver-metastases-a-comparative-study-based-on-single-center-experience-of-319-cases
#16
Suguru Yamashita, Yoshihiro Sakamoto, Satoshi Yamamoto, Nobuyuki Takemura, Kiyohiko Omichi, Hiroji Shinkawa, Kazuhiro Mori, Junichi Kaneko, Nobuhisa Akamatsu, Junichi Arita, Kiyoshi Hasegawa, Norihiro Kokudo
BACKGROUND: Efficacy of preoperative portal vein embolization (PVE) has been established; however, differences of outcomes among diseases, including hepatocellular carcinoma (HCC), biliary tract cancer (BTC), and colorectal liver metastases (CLM), are unclear. METHODS: Subjects included patients in a prospectively collected database undergoing PVE (from 1995 to 2013). A future liver remnant (FLR) volume ≥40% is the minimal requirement for patients with an indocyanine green retention rate at 15 min (ICGR15) <10%, and stricter criteria (FLR volume ≥50%) have been applied for patients with 20% > ICGR15 ≥ 10%...
February 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28188501/effect-of-extending-the-original-eligibility-criteria-for-the-cross-neoadjuvant-chemoradiotherapy-on-toxicity-and-survival-in-esophageal-cancer
#17
E C de Heer, J B Hulshoff, D Klerk, J G M Burgerhof, D J A de Groot, J Th M Plukker, G A P Hospers
BACKGROUND: Patients with curable esophageal cancer (EC) who proceed beyond the original Chemoradiotherapy for Oesophageal Cancer Followed by Surgery Study (CROSS) eligibility criteria are also treated with neoadjuvant chemoradiotherapy (nCRT). This study assessed the effect that extending the CROSS eligibility criteria for nCRT has on treatment-related toxicity and overall survival (OS) in EC. METHODS: The study enrolled 161 patients with locally advanced EC (T1N1-3/T2-4aN0-3/M0) treated with the CROSS schedule followed by esophagectomy...
February 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28188500/isolated-limb-perfusion-for-melanoma-is-safe-and-effective-in-elderly-patients
#18
Max F Madu, Marion M Deken, Jos A van der Hage, Katarzyna Jóźwiak, Michel W J M Wouters, Alexander C J van Akkooi
BACKGROUND: Data on isolated limb perfusion (ILP) in elderly melanoma patients are scarce. We aimed to evaluate the efficacy and safety of ILP in our institutional cohort of melanoma patients. METHODS: We performed retrospective analysis of stage IIIB/C melanoma patients who underwent ILP for melanoma in-transit metastases (ITMs) in our institution between 2000 and 2016. Normothermic ILP was performed with either melphalan or melphalan and tumor necrosis factor...
February 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28180987/preoperative-high-maximum-standardized-uptake-value-in-association-with-glucose-transporter-1-predicts-poor-prognosis-in-pancreatic-cancer
#19
Akira Chikamoto, Risa Inoue, Yoshiaki Komohara, Kentaro Sakamaki, Daisuke Hashimoto, Shinya Shiraishi, Hiroshi Takamori, Yo-Ichi Yamashita, Naoya Yoshida, Takeharu Yamanaka, Yasuyuki Yamashita, Hideo Baba
BACKGROUND: The diagnosis of malignant diseases worldwide has been determined using (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET). Glucose transporter type 1 (Glut-1) is a key protein associated with the accumulation of FDG in cancer cells. This study evaluated the relationship between Glut-1 expression and FDG accumulation to determine the usefulness of FDG-PET for prediction of long-term outcomes of pancreatic cancer. METHODS: The expression of Glut-1 was immunohistochemically examined in 138 surgically resected pancreatic cancer specimens...
February 8, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28176025/portal-vein-embolization-tailoring-optimizing-and-quantifying-an-invaluable-procedure-in-hepatic-surgery
#20
EDITORIAL
Jean-Nicolas Vauthey, Takashi Mizuno
No abstract text is available yet for this article.
February 7, 2017: Annals of Surgical Oncology
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