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Annals of Surgical Oncology

Tara L Spivey, Emily D Gutowski, Nantthasorn Zinboonyahgoon, Tari A King, Laura Dominici, Rob R Edwards, Mehra Golshan, Kristin L Schreiber
BACKGROUND: Chronic pain is an important complication of breast surgery, estimated to affect 20-30% of patients. We prospectively examined surgical, demographic, and psychosocial factors associated with chronic pain 6 months after breast surgery. METHODS: Patients undergoing breast surgery for benign and malignant disease preoperatively completed validated questionnaires to assess baseline pain and psychosocial characteristics. Pain at 6 months was quantified as the Pain Burden Index (PBI), which encompasses pain locations, severity, and frequency...
July 16, 2018: Annals of Surgical Oncology
Lucy M De La Cruz, Brian J Czerniecki
BACKGROUND: Although immunotherapy is making rapid inroads as a major treatment method for melanoma, lung, bladder, and hereditary colon cancer, breast cancer (BC) remains one of the tumors yet to experience the cellular immunology explosion despite the fact that heavy lymphocyte responses in breast tumors improve response to therapy and can predict for long-term survival. RESULTS: Immunotherapies in the form of monoclonal antibodies such as trastuzumab and pertuzumab have had an impact on HER2-positive breast cancer (HER2+BC) treatment through antibody-dependent cellular cytotoxicity...
July 16, 2018: Annals of Surgical Oncology
Brice Jabo, Ann C Lin, Mayada A Aljehani, Liang Ji, John W Morgan, Matthew J Selleck, Hahns Y Kim, Sharon S Lum
BACKGROUND: Delays in surgery and adjuvant treatment for breast cancer are associated with decreased survival. However, the time between diagnosis and surgery is rising, partly attributed to the added complexity of immediate breast reconstruction (IBR). We sought to investigate time to treatment and survival outcomes in breast cancer patients undergoing IBR. METHODS: We performed a retrospective review of 2004-2014 California Cancer Registry data for stage 0-III breast cancer patients undergoing mastectomy...
July 16, 2018: Annals of Surgical Oncology
Lisa Martin, Jessica Hopkins, Georgios Malietzis, J T Jenkins, Michael B Sawyer, Ron Brisebois, Anthony MacLean, Gregg Nelson, Leah Gramlich, Vickie E Baracos
BACKGROUND: Sarcopenia, visceral obesity (VO), and reduced muscle radiodensity (myosteatosis) are suggested risk factors for postoperative morbidity in colorectal cancer (CRC), but usually are not concurrently assessed. Published thresholds used to define these features are not CRC-specific and are defined in relation to mortality, not postoperative outcomes. This study aimed to evaluate body composition in relation to length of hospital stay (LOS) and postoperative outcomes. METHODS: Pre-surgical computed tomography (CT) images were assessed for total area and radiodensity of skeletal muscle and visceral adipose tissue in a pooled Canadian and UK cohort (n = 2100)...
July 13, 2018: Annals of Surgical Oncology
Sabrina Shilad, Cagri Cakmakoglu, Graham Schwarz, Stephanie Valente, Risal Djohan, Stephen Grobmyer
No abstract text is available yet for this article.
July 13, 2018: Annals of Surgical Oncology
Jeung Hui Pyo, Hyuk Lee, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Kyoung-Mee Kim, Heejin Yoo, Kyunga Kim, Yoon-Ho Choi, Jae J Kim, Sung Kim
BACKGROUND: Young patients with gastric cancer reportedly have a worse prognosis than older patients due to delayed diagnosis and more aggressive tumor behavior. However, it is unclear whether this applies to early gastric cancer (EGC), for which endoscopic resection is indicated. We investigated the association between age and lymph node metastasis (LNM). METHODS: We identified 4055 patients diagnosed with EGC of differentiated histology who underwent surgery. The association between age and LNM was examined using logistic regression for each T stage separately with adjustments for multiple covariates...
July 13, 2018: Annals of Surgical Oncology
Alexander V Fisher, Daniel E Abbott, Manasa Venkatesh, Glen E Leverson, Stephanie A Campbell-Flohr, Sean M Ronnekleiv-Kelly, Caprice C Greenberg, Emily R Winslow, Sharon M Weber
BACKGROUND: Many surgeons advocate the use of neoadjuvant treatment for resectable pancreatic cancer, however little is known about variation in the utilization of neoadjuvant therapy (NAT) at the hospital level. METHODS: The National Cancer Data Base was used to identify patients undergoing resection for pancreatic cancer between 2006 and 2014 at high-volume centers. Hospitals were grouped by NAT utilization using standard deviations (SD) from the mean as follows: high neoadjuvant utilizers (> 2 SDs above the mean, > 40% of patients receiving NAT); medium-high (1-2 SDs, 27-40%), medium (0-1 SD, 14-26%); or low (- 1...
July 12, 2018: Annals of Surgical Oncology
Mei Gao, Miranda Lin, Manisha Rao, Hannah Thompson, Kelsi Hirai, Minsig Choi, Georgios V Georgakis, Aaron R Sasson, Juan Carlos Bucobo, Demetri Tzimas, Lionel S D'Souza, Jonathan M Buscaglia, James Davis, Kenneth R Shroyer, Jinyu Li, Scott Powers, Joseph Kim
BACKGROUND: Organoids are three-dimensional in vitro models of human disease developed from benign and malignant gastrointestinal tissues with tremendous potential for personalized medicine applications. We sought to determine whether gastric cancer patient-derived organoids (PDOs) could be safely established from endoscopic biopsies for rapid drug screening. METHODS: Patients underwent esophagogastroduodenoscopy (EGD) for surveillance or staging and had additional forceps biopsies taken for PDO creation...
July 12, 2018: Annals of Surgical Oncology
Abhishek Chatterjee, Jennifer Gass, M Barbara Burke, Katherine Kopkash, Mahmoud B El-Tamer, Dennis R Holmes, Patricia Clark, Juliann Reiland
INTRODUCTION: Oncoplastic surgery is emerging as a validated, safe, patient-centric approach to breast cancer surgery in the United States. The American Society of Breast Surgeons Oncoplastic Surgery Committee (ASBrS-OSC) conducted a survey to assess the scope of practice and level of interest in oncoplastic surgery among its members. Furthermore, the group sought to identify barriers to incorporating oncoplastic skills in a surgeon's practice. METHODS: A 10-question survey was administered in March 2017 to the entire ASBrS membership using an online format...
July 12, 2018: Annals of Surgical Oncology
Shan Yang, Jennifer E Axilbund, Erin O'Leary, Scott T Michalski, Robbie Evans, Stephen E Lincoln, Edward D Esplin, Robert L Nussbaum
BACKGROUND: An estimated 5-10% of breast and ovarian cancers are due to hereditary causes such as hereditary breast and ovarian cancer (HBOC) syndrome. Medicare, the third-party payer that covers 44 million patients in the United States, has implemented a set of clinical criteria to determine coverage for the testing of the BRCA1 and BRCA2 genes. These criteria, developed to identify carriers of BRCA1/2 variants, have not been evaluated in the panel testing era. This study investigated a series of Medicare patients undergoing genetic testing for HBOC to determine the efficacy of genetic testing criteria in identifying patients with hereditary risk...
July 11, 2018: Annals of Surgical Oncology
Yu Ohkura, Masaki Ueno, Junichi Shindoh, Toshiro Iizuka, Hairin Ka, Harushi Udagawa
BACKGROUND: Chylothorax is one of the complications of esophagectomy for esophageal cancer. The treatment of this condition has been well discussed, but the risk factors for postoperative chylothorax remain unclear. METHODS: A retrospective review of 294 patients who underwent esophagectomy for esophageal cancer was conducted. These were patients with squamous cell carcinoma or adenocarcinoma of the esophagus including Siewert type I tumor of the esophagogastric junction who underwent subtotal esophagectomy with two-field or three-field lymphadenectomy...
July 11, 2018: Annals of Surgical Oncology
Kelly K Hunt, Hannah F Wingate
No abstract text is available yet for this article.
July 10, 2018: Annals of Surgical Oncology
Soojin Ahn, Margaux Wooster, Christopher Valente, Erin Moshier, Ru Meng, Kereeti Pisapati, Ronald Couri, Laurie Margolies, Hank Schmidt, Elisa Port
BACKGROUND: Screening mammography reduces breast cancer mortality; however, screening recommendations, ordering, and compliance remain suboptimal and controversies regarding the value of screening persist. We evaluated the influence of screening mammography on the extent of breast cancer treatment. METHODS: Patients ≥ 40 years of age diagnosed with breast cancer from September 2008 to May 2016 at a single institution were divided into two groups: those with screening 1-24 months prior to diagnosis, and those with screening at 25+ months, including patients with no prior mammography...
July 9, 2018: Annals of Surgical Oncology
Tasha M Hughes, Elizabeth N Palmer, Quinn Capers, Sherif Abdel-Misih, Alan Harzmann, Eliza Beal, Ingrid Woelfel, Sabrena Noria, Doreen Agnese, Mary Dillhoff, Valerie Grignol, J Harrison Howard, Lawrence A Shirley, Alicia Terando, Carl Schmidt, Jordan Cloyd, Timothy Pawlik
BACKGROUND: Obesity and cancer are two common diseases in the United States. Although there is an interaction of obesity and cancer, little is known about surgeon perceptions and practices in the care of obese cancer patients. We sought to characterize perceptions and practices of surgical oncologists regarding the perioperative care of obese patients being treated for cancer. METHODS: A cross-sectional survey was designed, pilot tested, and utilized to assess perceptions and practices of surgeons treating cancer patients...
July 9, 2018: Annals of Surgical Oncology
Sarah L Blair, Catherine Tsai, Lorraine Tafra
INTRODUCTION: Controversy over the need for sentinel node biopsy (SNB) continues to exist for the optimal treatment of breast cancer in patients ≥ 70 years of age, especially in those with lower-risk disease. Clinicians must balance competing risks to give the best individualized care. METHODS: The American Society of Breast Surgeons (ASBrS) conducted a debate discussing the pros and cons of routinely performing SNB in this age group. Small, randomized studies have been conducted that show no overall survival benefit to axillary intervention (either axillary dissection or SNB) in patients with clinically T1N0 estrogen receptor (ER)- and progesterone receptor (PR)-positive, HER2/neu-negative tumors...
July 9, 2018: Annals of Surgical Oncology
Johannes Asplund, Joonas H Kauppila, Fredrik Mattsson, Jesper Lagergren
BACKGROUND: Gastric adenocarcinoma is the second most common cancer-related death globally. Assessing survival trends can help evaluate changes in detection and treatment. We aimed to determine recent prognosis trends in gastric non-cardia and cardia adenocarcinoma in an unselected cohort with complete follow-up. METHODS: Population-based nationwide cohort study, including 17,491 patients with gastric non-cardia adenocarcinoma and 4698 with cardia adenocarcinoma recorded in the Swedish Cancer Registry in 1990-2013 with follow-up until 2017...
July 9, 2018: Annals of Surgical Oncology
Donald R Lannin
No abstract text is available yet for this article.
July 9, 2018: Annals of Surgical Oncology
Jenny Chang, Laura Denham, Eun Kyu Dong, Kirollos Malek, Sharon S Lum
BACKGROUND: In 2012, the World Health Organization (WHO) released diagnostic criteria for grading phyllodes tumors based on histologic features. This study sought to examine the application of the WHO criteria and the changing epidemiology of fibroepithelial tumors. METHODS: A retrospective review of surgically excised fibroepithelial lesions from 2007 to 2017 at a single tertiary care institution was conducted. Data regarding the WHO criteria (tumor border, stromal cellularity, stromal cell atypia, stromal overgrowth, mitotic activity) and traditional descriptors (leaf-like architecture, periductal stromal condensation) were collected...
July 9, 2018: Annals of Surgical Oncology
S Peter Wu, Moses Tam, Fauzia Shaikh, Anna Lee, Jennifer Chun, Freya Schnabel, Amber Guth, Sylvia Adams, David Schreiber, Cheonguen Oh, Naamit K Gerber
BACKGROUND: Recent data support the use of post-mastectomy radiation therapy (PMRT) in women with one to three positive lymph nodes; however, the benefit of PMRT in patients with micrometastatic nodal disease (N1mi) is unknown. We evaluated the survival impact of PMRT in patients with N1mi within the National Cancer Database. METHODS: The pattern of care and survival benefit of PMRT was examined in women with pT1-2N1mi breast cancer who underwent mastectomy without neoadjuvant chemotherapy...
July 9, 2018: Annals of Surgical Oncology
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