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Annals of Surgery

Anthony D Yang, Daniel Brock Hewitt, Eddie Blay, Lindsey J Kreutzer, Christopher M Quinn, Kimberly A Cradock, Vivek Prachand, Karl Y Bilimoria
OBJECTIVES: The aims of this study were to: (1) measure the rate of failure to provide defect-free postoperative venous thromboembolism (VTE) chemoprophylaxis, (2) identify reasons for failure to provide defect-free VTE chemoprophylaxis, and (3) examine patient- and hospital-level factors associated with failure. SUMMARY BACKGROUND DATA: Current VTE quality measures are inadequate. VTE outcome measures are invalidated for interhospital comparison by surveillance bias...
January 8, 2019: Annals of Surgery
Alma L Moekotte, Sanne Lof, Stijn Van Roessel, Martina Fontana, Stephan Dreyer, Alaaeldin Shablak, Fabio Casciani, Vasileios K Mavroeidis, Stuart Robinson, Khalid Khalil, George Gradinariu, Nicholas Mowbray, Bilal Al-Sarireh, Giuseppe Kito Fusai, Keith Roberts, Steve White, Zahir Soonawalla, Nigel B Jamieson, Roberto Salvia, Marc G Besselink, Mohammed Abu Hilal
OBJECTIVE: The aim of the study was to define histopathologic characteristics that independently predict overall survival (OS) and disease-free survival (DFS), in patients who underwent resection of an ampullary adenocarcinoma with curative intent. SUMMARY BACKGROUND DATA: A broad range of survival rates have been described for adenocarcinoma of the ampulla of Vater, presumably due to morphological heterogeneity which is a result of the different epitheliums ampullary adenocarcinoma can arise from (intestinal or pancreaticobiliary)...
January 7, 2019: Annals of Surgery
Oksana Babchenko, Catharine B Garland, Michael L Bentz, Samuel O Poore
No abstract text is available yet for this article.
January 3, 2019: Annals of Surgery
Sashwati Roy, Suman Santra, Amitava Das, Sriteja Dixith, Mithun Sinha, Subhadip Ghatak, Nandini Ghosh, Pradipta Banerjee, Savita Khanna, Shomita Mathew-Steiner, Piya Das Ghatak, Britani N Blackstone, Heather M Powell, Valerie K Bergdall, Daniel J Wozniak, Chandan K Sen
OBJECTIVE: The objective of this work was to causatively link biofilm properties of bacterial infection to specific pathogenic mechanisms in wound healing. BACKGROUND: Staphylococcus aureus is one of the four most prevalent bacterial species identified in chronic wounds. Causatively linking wound pathology to biofilm properties of bacterial infection is challenging. Thus, isogenic mutant stains of S. aureus with varying degree of biofilm formation ability was studied in an established preclinical porcine model of wound biofilm infection...
January 3, 2019: Annals of Surgery
Fernando Dip, Emanuelle LoMenzo, Luis Sarotto, Edward Phillips, Hernan Todeschini, Mario Nahmod, Lisandro Alle, Sylke Schneider, Ludwig Kaja, Luigi Boni, Pedro Ferraina, Thomas Carus, Norihiro Kokudo, Takeaki Ishizawa, Mathew Walsh, Conrad Simpfendorfer, Roy Mayank, Kevin White, Raul J Rosenthal
BACKGROUND: Incisionless near-infrared fluorescent cholangiography (NIFC) is emerging as a promising tool to enhance the visualization of extrahepatic biliary structures during laparoscopic cholecystectomies. METHODS: We conducted a single-blind, randomized, 2-arm trial comparing the efficacy of NIFC (n = 321) versus white light (WL) alone (n = 318) during laparoscopic cholecystectomy. Using the KARL STORZ Image1 S imaging system with OPAL1 technology for NIR/ICG imaging, we evaluated the detection rate for 7 biliary structures-cystic duct (CD), right hepatic duct (RHD), common hepatic duct, common bile duct, cystic common bile duct junction, cystic gallbladder junction (CGJ), and accessory ducts -before and after surgical dissection...
January 2, 2019: Annals of Surgery
Silvio Nadalin, Ivan Capobianco, Alfred Koenigsrainer
No abstract text is available yet for this article.
December 29, 2018: Annals of Surgery
Joaquim M Havens, Pooja U Neiman, Braidie L Campbell, Martin A Croce, David A Spain, Lena M Napolitano
No abstract text is available yet for this article.
December 29, 2018: Annals of Surgery
Katherine E Law, Bethany R Lowndes, Scott R Kelley, Renaldo C Blocker, David W Larson, M Susan Hallbeck, Heidi Nelson
OBJECTIVE: Surgeon workload, or human "cost" of performing a procedure, is not well understood in light of emerging surgical technologies. This pilot study quantified surgeon workload for colorectal procedures and identified patient, surgeon, and procedural factors impacting workload. SUMMARY BACKGROUND DATA: Innovative technologies and procedures in surgery have generally been promoted for the advancement of patient care. The resulting surgeon workload is poorly studied with little knowledge of the contributing factors impacting workload...
December 29, 2018: Annals of Surgery
Inca H R Hundscheid, Dirk H S M Schellekens, Joep Grootjans, Joep P M Derikx, Wim A Buurman, Cornelis H C Dejong, Kaatje Lenaerts
BACKGROUND AND OBJECTIVE: Sex differences in responses to intestinal ischemia-reperfusion (IR) have been recognized in animal studies. We aimed to investigate sexual dimorphism in human small intestinal mucosal responses to IR. METHODS: In 16 patients (8 men and 8 women) undergoing pancreaticoduodenectomy, an isolated part of jejunum was subjected to IR. In each patient, intestinal tissue and blood was collected directly after 45 minutes of ischemia without reperfusion (45I-0R), after 30 minutes of reperfusion (45I-30R), and after 120 minutes of reperfusion (45I-120R), as well as a control sample not exposed to IR, to assess epithelial damage, unfolded protein response (UPR) activation, and inflammation...
December 29, 2018: Annals of Surgery
Gao-Min Liu, Yao-Ming Zhang
No abstract text is available yet for this article.
December 29, 2018: Annals of Surgery
Regent Lee, Philip D Charles, Pierfrancesco Lapolla, Ismail Cassimjee, Honglei Huang, Benedikt Kessler, Roman Fischer, Ashok Handa
No abstract text is available yet for this article.
December 26, 2018: Annals of Surgery
Jaclyn T Mauch, Fabiola A Enriquez, Judy A Shea, Frances K Barg, Irfan A Rhemtulla, Robyn B Broach, Sheri L Thrippleton, John P Fischer
OBJECTIVE: Our study completes the development and estimates the psychometric properties of a novel, ventral hernia-specific patient reported outcomes (PRO) tool-the Abdominal Hernia-Q (AHQ). SUMMARY BACKGROUND DATA: A standardized method for measuring hernia-related PRO has not been identified. There remains a need for a broadly applicable, hernia-specific tool that incorporates patient viewpoints and offers pre- and postoperative forms. METHODS: Concept elicitation interviews, focus groups, and cognitive debriefing interviews were completed to define content...
December 26, 2018: Annals of Surgery
Joceline V Vu, David C Cron, Jay S Lee, Vidhya Gunaseelan, Pooja Lagisetty, Matthew Wixson, Michael J Englesbe, Chad M Brummett, Jennifer F Waljee
OBJECTIVE: We characterized patterns of preoperative opioid use in patients undergoing elective surgery to identify the relationship between preoperative use and subsequent opioid fill after surgery. BACKGROUND: Preoperative opioid use is common, and varies by dose, recency, duration, and continuity of fills. To date, there is little evidence to guide postoperative prescribing need based on prior opioid use. METHODS: We analyzed claims data from Clinformatics DataMart Database for patients aged 18 to 64 years undergoing major and minor surgery between 2008 and 2015...
December 26, 2018: Annals of Surgery
Richard Wagner, Colin Graydon, Oliver Johannes Deffaa
No abstract text is available yet for this article.
December 22, 2018: Annals of Surgery
Kristin A Sonderman, Lindsey L Wolf, Arin L Madenci, Nicollette K Kwon, Lindsey B Armstrong, Kerollos Nashat Wanis, Kathryn Taylor, Tarsicio Uribe-Leitz, Tracey P Koehlmoos, Robert L Ricca, Brent R Weil, Christopher B Weldon, Adil H Haider, Samuel E Rice-Townsend
OBJECTIVE: To describe variability in and consequences of opioid prescriptions following pediatric laparoscopic appendectomy. SUMMARY BACKGROUND DATA: Postoperative opioid prescribing patterns may contribute to persistent opioid use in both adults and children. METHODS: We included children <18 years enrolled as dependents in the Military Health System Data Repository who underwent uncomplicated laparoscopic appendectomy (2006-2014). For the primary outcome of days of opioids prescribed, we evaluated associations with discharging service, standardized to the distribution of baseline covariates...
December 22, 2018: Annals of Surgery
Erling Oma, Kristian K Jensen, Thue Bisgaard, Lars N Jorgensen
OBJECTIVE: To determine the optimal timing of elective repair, the primary objective of this study was to assess if parity at the time of repair and subsequent pregnancy were associated with reoperation for recurrence. The secondary objective was to examine if parity was associated with hernia formation requiring surgical repair. SUMMARY BACKGROUND DATA: Women of childbearing age constitute 18% of patients operated on for a primary ventral hernia, but consensus is lacking on the management in women who might subsequently become pregnant...
December 22, 2018: Annals of Surgery
Katsunori Nishikawa, Tetsuji Fujita, Masami Yuda, Yujiro Tanaka, Akira Matsumoto, Yuichiro Tanishima, Nobuyoshi Hanyu, Katsuhiko Yanaga
OBJECTIVE: The study's primary aim was to evaluate the effectiveness of thermal imaging (TI) and its secondary aim was to compare TI and indocyanine green (ICG) fluorescence angiography, with respect to the evaluation of the viability of the gastric conduit. SUMMARY BACKGROUND DATA: The optimal method for evaluating perfusion in the gastric conduit for esophageal reconstruction has not been established. METHODS: We reviewed the prospectively collected data of 263 patients who had undergone esophagectomy with gastric conduit reconstruction...
December 22, 2018: Annals of Surgery
Andrew M Ibrahim, Kyle H Sheetz, Justin B Dimick
No abstract text is available yet for this article.
December 21, 2018: Annals of Surgery
Alessandra L Moore, Heather E desJardins-Park, Bryan A Duoto, Shamik Mascharak, Matthew P Murphy, Dre M Irizarry, Deshka S Foster, Ruth E Jones, Leandra A Barnes, Clement D Marshall, Ryan C Ransom, Gerlinde Wernig, Michael T Longaker
OBJECTIVE: To investigate the effects of local doxycycline administration on skin scarring. BACKGROUND: Skin scarring represents a major source of morbidity for surgical patients. Doxycycline, a tetracycline antibiotic with off-target effects on the extracellular matrix, has demonstrated antifibrotic effects in multiple organs. However, doxycycline's potential effects on skin scarring have not been explored in vivo. METHODS: Female C57BL/6J mice underwent dorsal wounding following an established splinted excisional skin wounding model...
December 21, 2018: Annals of Surgery
Ashley M Kranz, Andrew Mulcahy, Teague Ruder, Susan Lovejoy, Ateev Mehrotra
OBJECTIVE: To describe patterns of postoperative visits reported for Medicare fee-for-service (FFS) patients. BACKGROUND: Payment for most surgical procedures bundles postoperative visits within a global period of either 10 or 90 days after a procedure. There is concern that payments for some procedures are excessive because the number of postoperative visits provided is less than the number of postoperative visits used to help determine payment. To obtain data to inform this concern, Medicare required select surgeons to report on their postoperative visits starting July 1, 2017...
December 21, 2018: Annals of Surgery
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