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Annals of Surgery

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https://www.readbyqxmd.com/read/28085696/commentary-on-a-proposed-road-map-for-the-ethical-evaluation-of-sham-placebo-surgery
#1
Peter Angelos
No abstract text is available yet for this article.
January 12, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28085695/incidence-of-occult-intrahepatic-metastasis-in-hepatocellular-carcinoma-treated-with-transplantation-corresponds-to-early-recurrence-rates-after-partial-hepatectomy
#2
David D Aufhauser, Eran Sadot, Douglas R Murken, Kevin Eddinger, Maarouf Hoteit, Peter L Abt, David S Goldberg, Ronald P DeMatteo, Matthew H Levine
OBJECTIVE: This study aimed to compare the incidence of radiologically unrecognized (occult) hepatocellular carcinoma (HCC) lesions in explant hepatectomy specimens from orthotopic liver transplants (OLTs) performed for HCC with rates of HCC intrahepatic recurrence after resection. SUMMARY OF BACKGROUND DATA: Resection of HCC is associated with high rates of intrahepatic HCC recurrence. However, it is unclear whether these recurrences represent incomplete resection of unrecognized metastatic lesions from the primary tumor or subsequent de novo tumor formation due to inherent biological proclivity for HCC formation...
January 12, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28085694/bioengineering-human-lung-grafts-on-porcine-matrix
#3
Haiyang Zhou, Kentaro Kitano, Xi Ren, Taufiek Konrad Rajab, Min Wu, Sarah E Gilpin, Tong Wu, Lauren Baugh, Lauren D Black, Douglas J Mathisen, Harald C Ott
OBJECTIVE: Bioengineering of viable, functional, and implantable human lung grafts on porcine matrix. SUMMARY BACKGROUND DATA: Implantable bioartificial organ grafts could revolutionize transplant surgery. To date, several milestones toward that goal have been achieved in rodent models. To make bioengineered organ grafts clinically relevant, scaling to human cells and graft size are the next steps. METHODS: We seeded porcine decellularized lung scaffolds with human airway epithelial progenitor cells derived from rejected donor lungs, and banked human umbilical vein endothelial cells...
January 12, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28067675/it-s-time-to-adopt-electronic-prescriptions-for-opioids
#4
Atul A Gawande
No abstract text is available yet for this article.
January 6, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28067674/a-pathology-of-mesh-and-time-dysejaculation-sexual-pain-and-orchialgia-resulting-from-polypropylene-mesh-erosion-into-the-spermatic-cord
#5
Vladimir Iakovlev, Andreas Koch, Kevin Petersen, John Morrison, David Grischkan, Vali Oprea, Robert Bendavid
OBJECTIVE: The ubiquitous use of polypropylene mesh in hernia surgery has spawned a new clinical syndrome: chronic post-herniorrhaphy neuralgia. A subset of that clinical picture is dysejaculation, sexual pain, and orchialgia. We propose to identify the processes that lead to that pain. SUMMARY OF BACKGROUND DATA: Specimens of vas adherent to polypropylene mesh, explanted in an attempt to control severe, life-changing inguinodynia are extremely difficult to obtain...
January 6, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28059833/pushing-the-limits-of-live-donor-liver-transplantation-is-the-western-world-ready-for-dual-grafts
#6
Gonzalo Sapisochin, Nicolas Goldaracena, David R Grant
No abstract text is available yet for this article.
January 4, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28059832/preoperative-disclosure-of-surgical-trainee-involvement-pandora-s-box-or-an-opportunity-for-enlightenment
#7
Brandon M Wojcik, Roy Phitayakorn, Keith D Lillemoe, David C Chang, John T Mullen
No abstract text is available yet for this article.
January 4, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28059834/what-do-we-know-about-intraoperative-teaching-a-systematic-review
#8
Matthew D Timberlake, Helen G Mayo, Lauren Scott, Joshua Weis, Aimee K Gardner
BACKGROUND: There is increasing attention on enhancing surgical trainee performance and competency. The purpose of this review is to identify characteristics and themes related to intraoperative teaching that will better inform interventions and assessment endeavors. METHODS: A systematic search was carried out of the Ovid MEDLINE, Ovid MEDLINE InProcess, Ovid Embase, and the Cochrane Library databases to identify all studies that discussed teaching in the operating room for trainees at the resident and fellow level...
January 3, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28045719/hepatic-histology-and-morphometric-measurements-in-idiopathic-extrahepatic-portal-vein-thrombosis-in-children-correlated-to-clinical-outcome-of-meso-rex-bypass
#9
Niramol Tantemsapya, Riccardo Superina, Deli Wang, Grace Kronauer, Peter F Whitington, Hector Melin-Aldana
OBJECTIVE: The aim of this study was to correlate clinical, histologic, and morphometric features of the liver in children with extrahepatic portal vein thrombosis (EHPVT), with surgical outcome after Meso-Rex bypass (MRB). BACKGROUND: Idiopathic EHPVT, a significant cause of portal hypertension, is surgically corrected by MRB. Correlation of histologic and morphometric features of the liver with outcome has not been reported in children. METHODS: We retrospectively reviewed clinical and intraoperative data of 45 children with idiopathic EHPVT...
December 30, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28045718/william-francis-rienhoff-jr-md-halsted-s-last-resident
#10
Richard F Heitmiller
William Francis Rienhoff Jr. was a skilled and innovative surgeon whose career spanned over 4 decades of patient care, clinical investigative research, and surgical education. He was an unforgettable character for those who knew him. Colleagues, coworkers, and friends developed strong and divergent opinions of him. His professional life coincided with the early development of general and thoracic surgery to which he contributed.
December 30, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28045717/value-of-propensity-score-matching-to-study-surgical-outcomes
#11
E Shelley Hwang, Xiaofei Wang
No abstract text is available yet for this article.
December 30, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28045716/what-is-the-impact-of-intraoperative-re-resection-after-a-positive-pancreatic-margin-frozen-section-in-the-era-of-perioperative-therapies
#12
Philipp Nitschke, Jürgen Weitz, Nuh N Rahbari
No abstract text is available yet for this article.
December 30, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28045715/oncologic-procedures-amenable-to-fluorescence-guided-surgery
#13
Kiranya E Tipirneni, Jason M Warram, Lindsay S Moore, Andrew C Prince, Esther de Boer, Aditi H Jani, Irene L Wapnir, Joseph C Liao, Michael Bouvet, Nicole K Behnke, Mary T Hawn, George A Poultsides, Alexander L Vahrmeijer, William R Carroll, Kurt R Zinn, Eben Rosenthal
OBJECTIVE: Although fluorescence imaging is being applied to a wide range of cancers, it remains unclear which disease populations will benefit greatest. Therefore, we review the potential of this technology to improve outcomes in surgical oncology with attention to the various surgical procedures while exploring trial endpoints that may be optimal for each tumor type. BACKGROUND: For many tumors, primary treatment is surgical resection with negative margins, which corresponds to improved survival and a reduction in subsequent adjuvant therapies...
December 30, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28045714/how-much-should-we-pay-to-minimize-pancreatic-leak-the-cost-effectiveness-of-pasireotide-in-pancreatic-resection-retracted
#14
Daniel E Abbott, Jeffrey M Sutton, Peter L Jernigan, Alex Chang, Patrick Frye, Shimul A Shah, Daniel P Schauer, Mark H Eckman, Syed A Ahmad, Jeffrey J Sussman
INTRODUCTION: Pasireotide was recently shown to decrease leak rates after pancreatic resection, though the significant cost of the drug may be prohibitive. We conducted a cost-effectiveness analysis to determine whether prophylactic pasireotide possesses a reasonable cost profile by improving outcomes. METHODS: A cost-effectiveness model was constructed to compare pasireotide administration after pancreatic resection versus usual care, populated by probabilities of clinical outcomes from a recent randomized trial and hospital costs (2013 US$) from a university pancreatic disease center...
December 30, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28045744/open-pancreaticoduodenectomy-case-volume-predicts-outcome-of-laparoscopic-approach-a-population-based-analysis
#15
Onur C Kutlu, Jeffrey E Lee, Matthew H Katz, Ching-Wei D Tzeng, Robert A Wolff, Gauri R Varadhachary, Jean-Nicolas Vauthey, Jason B Fleming, Claudius Conrad
OBJECTIVE: To determine if laparoscopic pancreaticoduodenectomy (LPD) is safe and offers benefits over open pancreaticoduodenectomy (OPD) at institutions with lower pancreaticoduodenectomy (PD) volume. BACKGROUND: Although a hospital-based case volume-outcome relationship for morbidity, mortality, and oncologic quality has been reported for OPD, comparative trends for LPD have yet to be investigated. METHODS: A total of 4739 patients with complete data were identified in National Cancer Data Base between 2010 and 2011; 4309 patients had OPD and 430 patients had LPD...
December 29, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28027060/methodological-quality-of-surgical-mortality-studies-using-large-hospital-databases-a-systematic-review
#16
Cécile Payet, Jean-Christophe Lifante, Matthew J Carty, Muriel Rabilloud, Antoine Duclos
OBJECTIVE: To review the methodology employed in surgical mortality studies to control for potential confounders. SUMMARY BACKGROUND DATA: Nationwide hospital data are increasingly used to investigate surgical outcomes. However, poor data granularity and coding inaccuracies may lead to flawed findings. METHODS: We conducted a systematic review in accordance with the PRISMA statement in 6 major journals (NEJM, Lancet, BMJ, JAMA, Medical Care, Annals of Surgery) using PubMed from its inception until December 31, 2014...
December 23, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28002059/immunoscore-signature-a-prognostic-and-predictive-tool-in-gastric-cancer
#17
Yuming Jiang, Qi Zhang, Yanfeng Hu, Tuanjie Li, Jiang Yu, Liying Zhao, Gengtai Ye, Haijun Deng, Tingyu Mou, Shirong Cai, Zhiwei Zhou, Hao Liu, Guihua Chen, Guoxin Li, Xiaolong Qi
OBJECTIVE: We postulated that the ImmunoScore (IS) could markedly improve the prediction of postsurgical survival and chemotherapeutic benefits in gastric cancer (GC). SUMMARY BACKGROUND DATA: A prediction model for GC patients was developed using data from 879 consecutive patients. METHODS: The expression of 27 immune features was detected in 251 specimens by using immunohistochemistry, and a 5-feature-based ISGC was then constructed using the LASSO Cox regression model...
December 20, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28002061/response-to-letter-to-the-editor-regarding-the-cobra-trial-what-will-it-take-to-perform-high-quality-hernia-research
#18
Michael J Rosen
No abstract text is available yet for this article.
December 19, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28002060/embryonic-origin-of-primary-colon-cancer-predicts-pathologic-response-and-survival-in-patients-undergoing-resection-for-colon-cancer-liver-metastases
#19
Suguru Yamashita, Kristoffer Watten Brudvik, Scott E Kopetz, Dipen Maru, Callisia N Clarke, Guillaume Passot, Claudius Conrad, Yun Shin Chun, Thomas A Aloia, Jean-Nicolas Vauthey
BACKGROUND: The aim of this study was to determine the prognostic value of embryonic origin in patients undergoing resection after chemotherapy for colon cancer liver metastases (CCLM). METHODS: We identified 725 patients with primary colon cancer and known RAS mutation status who underwent hepatic resection after preoperative chemotherapy for CCLM (1990 to 2015). Survival after resection of CCLM from midgut origin (n = 238) and hindgut origin (n = 487) was analyzed...
December 19, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27997472/ensuring-early-mobilization-within-an-enhanced-recovery-program-for-colorectal-surgery-a-randomized-controlled-trial
#20
Julio Flavio Fiore, Tanya Castelino, Nicolò Pecorelli, Petru Niculiseanu, Saba Balvardi, Olivia Hershorn, Sender Liberman, Patrick Charlebois, Barry Stein, Franco Carli, Nancy Mayo, Liane S Feldman
OBJECTIVE: To estimate the extent to which the addition of staff-directed facilitation of early mobilization to an Enhanced Recovery Program (ERP) impacts recovery after colorectal surgery, compared with usual care. SUMMARY BACKGROUND DATA: Early mobilization is considered an important component of ERPs but, despite guidelines recommendations, adherence remains quite low. The value of dedicating specific resources (eg, staff time) to increase early mobilization is unknown...
December 16, 2016: Annals of Surgery
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