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Annals of Surgery

Chi-Fu Jeffrey Yang, Arvind Kumar, Mark F Berry, Thomas A D'Amico
No abstract text is available yet for this article.
November 6, 2018: Annals of Surgery
Jennifer H Kuo, Quan Y Duh, Herbert Chen, Victoria Lai, Meredith J Sorensen, John A Chabot, James A Lee
OBJECTIVE: To examine the evolution of an academic endocrine surgeon's practice over time. SUMMARY BACKGROUND: Amid growing recognition that surgical volume and specialization are linked to better outcomes, endocrine surgery is one of the youngest fields to develop its own formal fellowship training program. However, 3 decades after the emergence of endocrine surgery as a distinct specialty, the medical community and public still have a limited understanding of endocrine surgeons and what they do...
November 6, 2018: Annals of Surgery
Laura L Meijer, Ingrid Garajová, Chiara Caparello, Tessa Y S Le Large, Adam E Frampton, Enrico Vasile, Niccola Funel, Geert Kazemier, Elisa Giovannetti
OBJECTIVE: The aim of the study was to identify plasma microRNA (miRNA) biomarkers for stratifying and monitoring patients with locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC) treated with FOLFIRINOX, and to investigate their functional roles. SUMMARY BACKGROUND DATA: FOLFIRINOX has become a standard therapy for patients with advanced PDAC and can be used to potentially downstage disease. However, only a subset of patients respond, and biomarkers to guide decision-making are urgently needed...
November 1, 2018: Annals of Surgery
Gregory A Dumanian, Benjamin K Potter, Lauren M Mioton, Jason H Ko, Jennifer E Cheesborough, Jason M Souza, William J Ertl, Scott M Tintle, George P Nanos, Ian L Valerio, Todd A Kuiken, A Vania Apkarian, Kyle Porter, Sumanas W Jordan
OBJECTIVE: To compare targeted muscle reinnervation (TMR) to "standard treatment" of neuroma excision and burying into muscle for postamputation pain. SUMMARY BACKGROUND DATA: To date, no intervention is consistently effective for neuroma-related residual limb or phantom limb pain (PLP). TMR is a nerve transfer procedure developed for prosthesis control, incidentally found to improve postamputation pain. METHODS: A prospective, randomized clinical trial was conducted...
October 26, 2018: Annals of Surgery
Andrew Gelman
No abstract text is available yet for this article.
October 25, 2018: Annals of Surgery
Robert Bendavid
No abstract text is available yet for this article.
October 18, 2018: Annals of Surgery
Craig White, Milton C Weinstein, Abbey L Fingeret, Gregory W Randolph, Akira Miyauchi, Yasuhiro Ito, Tiannan Zhan, Ayman Ali, G Scott Gazelle, Carrie C Lubitz
OBJECTIVE: To assess relative clinical and economic performance of the revised American Thyroid Association (ATA) thyroid cancer guidelines compared to current standard of care. BACKGROUND: Diagnosis of thyroid cancer in the United States has tripled whereas mortality has only marginally increased. Most patients present with small papillary carcinomas and have historically received at least a total thyroidectomy as a treatment. In 2015, the ATA released the revised guidelines recommending an option for active surveillance (AS) of small papillary thyroid carcinoma and thyroid lobectomy for larger unifocal tumors...
October 17, 2018: Annals of Surgery
Antonio Pea, Jun Yu, Luigi Marchionni, Michael Noe, Claudio Luchini, Alessandra Pulvirenti, Roeland F de Wilde, Lodewijk A Brosens, Neda Rezaee, Ammar Javed, Stefano Gobbo, Paolo Regi, Roberto Salvia, Claudio Bassi, Jin He, Matthew J Weiss, John L Cameron, G Johan A Offerhaus, Ralph H Hruban, Rita T Lawlor, Aldo Scarpa, Christopher M Heaphy, Laura D Wood, Christopher L Wolfgang
OBJECTIVE: The aim of this study was to investigate the key molecular alterations in small primary pancreatic neuroendocrine tumors (PanNETs) associated with the development of liver metastases. BACKGROUND: Well-differentiated PanNETs with small size are typically indolent; however, a limited subset metastasize to the liver. METHODS: A total of 87 small primary PanNETs (<3 cm), including 32 metastatic cases and 55 nonmetastatic cases after a 5-year follow-up, were immunolabeled for DAXX/ATRX and analyzed for alternative lengthening of telomeres (ALT) by Fluorescence In Situ Hybridization...
October 17, 2018: Annals of Surgery
Jordan M Cloyd, Takashi Mizuno, Yoshikuni Kawaguchi, Heather A Lillemoe, Georgios Karagkounis, Kiyohiko Omichi, Yun Shin Chun, Claudius Conrad, Ching-Wei D Tzeng, Bruno C Odisio, Steven Y Huang, Marshall Hicks, Steven H Wei, Thomas A Aloia, Jean-Nicolas Vauthey
OBJECTIVE: The aim of this study was to evaluate trends over time in perioperative outcomes for patients undergoing hepatectomy. BACKGROUND: As perioperative care and surgical technique for hepatectomy have improved, the indications for and complexity of liver resections have evolved. However, the resulting effect on the short-term outcomes over time has not been well described. METHODS: Consecutive patients undergoing hepatectomy during 1998 to 2015 at 1 institution were analyzed...
October 17, 2018: Annals of Surgery
Shogo Kobayashi, Hiroaki Nagano, Akira Tomokuni, Kunihito Gotoh, Daisuke Sakai, Etsuro Hatano, Satoru Seo, Hiroaki Terajima, Yoichiro Uchida, Tetsuo Ajiki, Hironaga Satake, Keiko Kamei, Taiji Tohyama, Tetsuro Hirose, Iwao Ikai, Satoshi Morita, Tatsuya Ioka
OBJECTIVE: To evaluate each arm independently and compare adjuvant gemcitabine (GEM) and S-1 chemotherapy after major hepatectomy (hemihepatectomy or trisectionectomy) for biliary tract cancer (BTC). BACKGROUND: Standardized adjuvant therapy is not performed after major hepatectomy for BTC, and we determined the recommended dose in the former study (KHBO1003). METHODS: We performed a multicenter, randomized phase II study. The primary measure was 1-year recurrence-free survival (RFS); the secondary measures were other RFS, overall survival (OS), and others...
October 17, 2018: Annals of Surgery
Joonas H Kauppila, Asif Johar, Pernilla Lagergren
OBJECTIVE: To evaluate the impact of postoperative medical and surgical complications on health-related quality of life (HRQOL) in esophageal cancer. BACKGROUND: Complications after esophageal surgery negatively affect HRQOL, but it is unclear whether medical and surgical complications differ in effects. METHODS: This Swedish population-based, nationwide, and prospective cohort study enrolled 616 patients undergoing esophageal cancer surgery during 2001 to 2005, with 10 years of follow-up...
October 17, 2018: Annals of Surgery
Jason D Keune
No abstract text is available yet for this article.
October 17, 2018: Annals of Surgery
Sergio A Acuna, Tyler R Chesney, Joshua K Ramjist, Prakesh S Shah, Erin D Kennedy, Nancy N Baxter
OBJECTIVE: To determine whether laparoscopic surgery is noninferior to open surgery for rectal cancer in terms of quality of surgical resection outcomes. BACKGROUND: Randomized clinical trials (RCTs) have evaluated the oncologic safety of laparoscopic versus open surgery for rectal cancer with conflicting results. Prior meta-analyses comparing these operative approaches in terms of quality of surgical resection aimed to demonstrate if one approach was superior. However, this method is not appropriate and potentially misleading when noninferiority RCTs are included...
October 17, 2018: Annals of Surgery
Jeroen E H Ponten, Wouter K G Leclercq, Tanja Lettinga, Jeroen Heemskerk, Joop L M Konsten, Nicole D Bouvy, Simon W Nienhuijs
OBJECTIVE: The objective of this trial was to identify a superior method for umbilical and epigastric hernia repair in terms of complications. Complications such as an extended operation duration, additional use of painkillers, reoperation, infection, seroma, extended wound care, extended hospitalization, and early recurrence were reported according to the Clavien-Dindo grading system. SUMMARY BACKGROUND DATA: Over the years mesh repair is proven the gold standard for umbilical and epigastric hernias...
October 17, 2018: Annals of Surgery
Giuseppe Malleo, Laura Maggino, Cristina R Ferrone, Giovanni Marchegiani, Andrew L Warshaw, Keith D Lillemoe, Claudio Bassi, Carlos Fernàndez-Del Castillo, Roberto Salvia
OBJECTIVE: To reappraise the concept of conditional survival (CS) following pancreatectomy for pancreatic ductal adenocarcinoma (PDAC), accounting for the patient's present disease status relative to recurrence. BACKGROUND: CS, defined as the probability of surviving an additional time frame based on accrued lifespan, offers dynamic survival projections as compared with baseline overall survival. METHODS: Patients undergoing pancreatectomy for PDAC at 2 institutions from 2000 to 2013 were retrospectively analyzed...
October 17, 2018: Annals of Surgery
Fredrik Lohmander, Jakob Lagergren, Pankaj G Roy, Hemming Johansson, Yvonne Brandberg, Catharina Eriksen, Jan Frisell
OBJECTIVE: To evaluate clinical outcomes of using acellular dermal matrix (ADM) with implant based breast reconstructions (IBBRs) in a randomized controlled trial. SUMMARY BACKGROUND DATA: The use of ADMs in IBBRs is widespread, but link between ADM and complications remain a controversial topic. In view of reports concerning harm, we present 6-months safety data of ADM-assisted IBBR in the setting of breast cancer treatment. METHODS: An open-label, randomized, controlled trial recruiting patients from 4 centers in Sweden and 1 in UK...
October 17, 2018: Annals of Surgery
Benjamin S Brooke
No abstract text is available yet for this article.
October 11, 2018: Annals of Surgery
Alberto Biondi, Roberto Persiani
No abstract text is available yet for this article.
October 11, 2018: Annals of Surgery
Laurence Chiche
No abstract text is available yet for this article.
October 11, 2018: Annals of Surgery
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