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Annals of the Rheumatic Diseases

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https://www.readbyqxmd.com/read/29779010/low-mir200b-5p-levels-in-minor-salivary-glands-a-novel-molecular-marker-predicting-lymphoma-development-in-patients-with-sj%C3%A3-gren-s-syndrome
#1
Efstathia K Kapsogeorgou, Aristea Papageorgiou, Athanase D Protogerou, Michael Voulgarelis, Athanasios G Tzioufas
OBJECTIVES: Development of non-Hodgkin's lymphoma (NHL) is the major adverse outcome of Sjögren's syndrome (SS) affecting both morbidity and mortality. Preliminary evidence suggested that, although not deregulated compared with sicca controls, miR200b-5p levels are decreased in the minor salivary glands (MSGs) of SS patients with NHL. The aim of the current study was to evaluate the MSG expression of miR200b-5p in SS-associated NHLs and its potential predictive value for the identification of patients with SS susceptible to develop NHL...
May 19, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29776976/anticardiolipin-and-anti-beta-2-glycoprotein-i-antibodies-disappearance-in-patients-with-systemic-lupus-erythematosus-and-antiphospholipid-syndrome-while-on-belimumab
#2
LETTER
Savino Sciascia, Elena Rubini, Massimo Radin, Irene Cecchi, Daniela Rossi, Dario Roccatello
No abstract text is available yet for this article.
May 18, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29776975/response-to-to-dapsa-or-not-to-dapsa-that-is-not-the-question-by-schoels-et-al
#3
Leonieke J J van Mens, Marleen G H van de Sande, Arno W R van Kuijk, Dominique L P Baeten, Laura C Coates
No abstract text is available yet for this article.
May 18, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29764835/infrapatellar-fat-pad-resection-during-total-knee-arthroplasty-yet-another-reason-for
#4
LETTER
Thomas J Ryan
No abstract text is available yet for this article.
May 15, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29760159/inadequate-response-to-treat-to-target-methotrexate-therapy-in-patients-with-new-onset-rheumatoid-arthritis-development-and-validation-of-clinical-predictors
#5
Xavier M Teitsma, Johannes W G Jacobs, Paco M J Welsing, Pascal H P de Jong, Johanna M W Hazes, Angelique E A M Weel, Attila Pethö-Schramm, Michelle E A Borm, Jacob M van Laar, Floris P J G Lafeber, Johannes W J Bijlsma
OBJECTIVE: To identify and validate clinical baseline predictors associated with inadequate response (IR) to methotrexate (MTX) therapy in newly diagnosed patients with rheumatoid arthritis (RA). METHODS: In U-Act-Early, 108 disease-modifying antirheumatic drug (DMARD)-naive patients with RA were randomised to initiate MTX therapy and treated to target until sustained remission (disease activity score assessing 28 joints (DAS28) <2.6 with four or less swollen joints for ≥24 weeks) was achieved...
May 14, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29760158/checkpoint-inhibitor-induced-polymyalgia-rheumatica-controlled-by-cobimetinib-a-mek-1-2-inhibitor
#6
LETTER
Karmela Kim Chan, Anne R Bass
No abstract text is available yet for this article.
May 14, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29760157/methyl-cpg-binding-protein-2-mediates-antifibrotic-effects-in-scleroderma-fibroblasts
#7
Ye He, Pei-Suen Tsou, Dinesh Khanna, Amr H Sawalha
OBJECTIVE: Emerging evidence supports a role for epigenetic regulation in the pathogenesis of scleroderma (SSc). We aimed to assess the role of methyl-CpG-binding protein 2 (MeCP2), a key epigenetic regulator, in fibroblast activation and fibrosis in SSc. METHODS: Dermal fibroblasts were isolated from patients with diffuse cutaneous SSc (dcSSc) and from healthy controls. MeCP2 expression was measured by qPCR and western blot. Myofibroblast differentiation was evaluated by gel contraction assay in vitro...
May 14, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29760156/improved-survival-with-renal-transplantation-for-end-stage-renal-disease-due-to-granulomatosis-with-polyangiitis-data-from-the-united-states-renal-data-system
#8
Zachary S Wallace, Rachel Wallwork, Yuqing Zhang, Na Lu, Frank Cortazar, John L Niles, Eliot Heher, John H Stone, Hyon K Choi
BACKGROUND: Renal transplantation is the optimal treatment for selected patients with end-stage renal disease (ESRD). However, the survival benefit of renal transplantation among patients with ESRD attributed to granulomatosis with polyangiitis (GPA) is unknown. METHODS: We identified patients from the United States Renal Data System with ESRD due to GPA (ESRD-GPA) between 1995 and 2014. We restricted our analysis to waitlisted subjects to evaluate the impact of transplantation on mortality...
May 14, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29760155/association-of-circulating-cxcl10-and-cxcl11-with-systemic-sclerosis
#9
LETTER
Clara Crescioli, Clarissa Corinaldesi, Valeria Riccieri, Valeria Raparelli, Massimiliano Vasile, Francesco Del Galdo, Guido Valesini, Andrea Lenzi, Stefania Basili, Cristina Antinozzi
No abstract text is available yet for this article.
May 14, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29730639/response-to-pitfalls-of-antinuclear-antibody-detection-in-systemic-lupus-erythematosus-the-positive-experience-of-a-national-multi-center-study-by-pregnalato-et-al
#10
David S Pisetsky, Diane M Spencer, Peter E Lipsky, Brad H Rovin
No abstract text is available yet for this article.
May 5, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29730638/response-to-variation-in-antinuclear-antibody-detection-by-automated-indirect-immunofluorescence-analysis-by-van-hoovels-et-al
#11
David S Pisetsky, Diane M Spencer, Peter E Lipsky, Brad H Rovin
No abstract text is available yet for this article.
May 5, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29730637/comparative-effectiveness-of-tocilizumab-versus-tnf-inhibitors-as-monotherapy-or-in-combination-with-conventional-synthetic-disease-modifying-antirheumatic-drugs-in-patients-with-rheumatoid-arthritis-after-the-use-of-at-least-one-biologic-disease-modifying
#12
Kim Lauper, Dan C Nordström, Karel Pavelka, Maria Victoria Hernández, Tore K Kvien, Eirik Klami Kristianslund, Maria Jose Santos, Žiga Rotar, Florenzo Iannone, Catalin Codreanu, Galina Lukina, Sara L Gale, Khaled Sarsour, Yves Luder, Delphine Sophie Courvoisier, Cem Gabay
OBJECTIVE: To compare the effectiveness of tocilizumab (TCZ) and tumour necrosis factor (TNF) inhibitors (TNFi) as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA) after the use of at least one biologic DMARD (bDMARD). METHODS: We included patients with RA having used at least one bDMARD from 10 European registries. We compared drug retention using Kaplan-Meier and Cox models and Clinical Disease Activity Index (CDAI) change over time with mixed-effects models for longitudinal data...
May 5, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29730636/platelet-activation-as-measured-by-plasma-soluble-glycoprotein-vi-is-not-associated-with-disease-activity-or-ischaemic-events-in-giant-cell-arteritis
#13
LETTER
Richard Conway, Anne Madigan, Niamh Redmond, Laura Helbert, Eamonn S Molloy, Eimear Dunne, Dermot Kenny, Geraldine McCarthy
No abstract text is available yet for this article.
May 5, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29730635/to-dapsa-or-not-to-dapsa-that-is-not-the-question
#14
LETTER
Monika M Schoels, Josef S Smolen, Daniel Aletaha
No abstract text is available yet for this article.
May 5, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29730634/changing-patterns-in-clinical-histological-presentation-and-renal-outcome-over-the-last-five-decades-in-a-cohort-of-499-patients-with-lupus-nephritis
#15
Gabriella Moroni, Paolo Gilles Vercelloni, Silvana Quaglini, Mariele Gatto, Davide Gianfreda, Lucia Sacchi, Francesca Raffiotta, Margherita Zen, Gloria Costantini, Maria Letizia Urban, Federico Pieruzzi, Piergiorgio Messa, Augusto Vaglio, Renato Alberto Sinico, Andrea Doria
OBJECTIVES: To evaluate changes in demographic, clinical and histological presentation, and prognosis of lupus nephritis (LN) over time. PATIENTS AND METHODS: We studied a multicentre cohort of 499 patients diagnosed with LN from 1970 to 2016. The 46-year follow-up was subdivided into three periods (P): P1 1970-1985, P2 1986-2001 and P3 2002-2016, and patients accordingly grouped based on the year of LN diagnosis. Predictors of patient and renal survival were investigated by univariate and multivariate proportional hazards Cox regression analyses...
May 5, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29724733/effects-of-immune-checkpoint-inhibitors-on-b-cells-relationship-to-immune-related-adverse-events
#16
David S Pisetsky
No abstract text is available yet for this article.
May 3, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29724732/tofacitinib-in-steroid-dependent-relapsing-polychondritis
#17
LETTER
Alexey D Meshkov, Pavel I Novikov, Evgeny V Zhilyaev, Ilia David J Ilevsky, Sergey V Moiseev
No abstract text is available yet for this article.
May 3, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29724731/exposure-to-passive-smoking-and-rheumatoid-arthritis-risk-results-from-the-swedish-eira-study
#18
Anna Karin Hedström, Lars Klareskog, Lars Alfredsson
INTRODUCTION: Smoking has consistently been associated with increased risk of developing rheumatoid arthritis (RA). The aim of this study was to estimate the influence of passive smoking on the risk of developing anti-cyclic citrullinated peptide antibodies (ACPA)-positive and ACPA-negative RA. METHODS: A population-based case-control study using incident cases of RA was performed in Sweden, and the study population in this report was restricted to include never-smokers (589 cases, 1764 controls)...
May 3, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29724730/metabolic-pathways-and-immunometabolism-in-rare-kidney-diseases
#19
Peter C Grayson, Sean Eddy, Jaclyn N Taroni, Yaíma L Lightfoot, Laura Mariani, Hemang Parikh, Maja T Lindenmeyer, Wenjun Ju, Casey S Greene, Brad Godfrey, Clemens D Cohen, Jeffrey Krischer, Matthias Kretzler, Peter A Merkel
OBJECTIVES: To characterise renal tissue metabolic pathway gene expression in different forms of glomerulonephritis. METHODS: Patients with nephrotic syndrome (NS), antineutrophil cytoplasmic antibody-associated vasculitis (AAV), systemic lupus erythematosus (SLE) and healthy living donors (LD) were studied. Clinically indicated renal biopsies were obtained at time of diagnosis and microdissected into glomerular and tubulointerstitial compartments. Microarray-derived differential gene expression of 88 genes representing critical enzymes of metabolic pathways and 25 genes related to immune cell markers was compared between disease groups...
May 3, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29724729/long-term-efficacy-of-remission-maintenance-regimens-for-anca-associated-vasculitides
#20
Benjamin Terrier, Christian Pagnoux, Élodie Perrodeau, Adexandre Karras, Chahera Khouatra, Olivier Aumaître, Pascal Cohen, Olivier Decaux, Hélène Desmurs-Clavel, François Maurier, Pierre Gobert, Thomas Quémeneur, Claire Blanchard-Delaunay, Bernard Bonnotte, Pierre-Louis Carron, Eric Daugas, Marize Ducret, Pascal Godmer, Mohamed Hamidou, Olivier Lidove, Nicolas Limal, Xavier Puéchal, Luc Mouthon, Philippe Ravaud, Loïc Guillevin
OBJECTIVE: To compare long-term efficacy of remission-maintenance regimens in patients with newly diagnosed or relapsing antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides. METHODS: The 28-month Maintenance of Remission using Rituximab in Systemic ANCA-associated Vasculitis trial compared rituximab with azathioprine to maintain remission in patients with newly diagnosed or relapsing granulomatosis with polyangiitis, microscopic polyangiitis or renal-limited ANCA-associated vasculitis...
May 3, 2018: Annals of the Rheumatic Diseases
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