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Annals of the Rheumatic Diseases

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https://www.readbyqxmd.com/read/30030264/is-mir200b-5p-a-new-predictor-of-lymphoma-or-associated-with-lymphocytes-infiltrate-within-salivary-glands
#1
LETTER
Gaetane Nocturne, Raphaele Seror, Xavier Mariette
No abstract text is available yet for this article.
July 20, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30030263/frequency-of-tumour-necrosis-factor-alpha-receptor-superfamily-1a-multiple-sclerosis-associated-variants-in-patients-with-rheumatoid-arthritis-with-anti-tumour-necrosis-factor-therapy-related-demyelinating-complications
#2
LETTER
Samuel Bitoun, Corinne Miceli-Richard, Céline Verstuyft, Pierre Antoine Juge, Philippe Dieudé, Jean-Marie Berthelot, Christophe Richez, Cécile Cauquil, Christelle Sordet, Sylvie Melac-Ducamp, Laure Gossec, Beatrice Bouvard, Emmanuelle Dernis, Eric Houvenagel, Marie-Astrid Boutry-Bacle, Xavier Mariette, Raphaèle Seror
No abstract text is available yet for this article.
July 20, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30030262/multi-omics-analyses-unveil-stat1-as-a-potential-modifier-gene-in-mevalonate-kinase-deficiency
#3
Raphael Carapito, Christine Carapito, Aurore Morlon, Nicodème Paul, Alvaro Sebastian Vaca Jacome, Ghada Alsaleh, Véronique Rolli, Ouria Tahar, Ismail Aouadi, Magali Rompais, François Delalande, Angélique Pichot, Philippe Georgel, Laurent Messer, Jean Sibilia, Sarah Cianferani, Alain Van Dorsselaer, Seiamak Bahram
OBJECTIVES: The objective of the present study was to explain why two siblings carrying both the same homozygous pathogenic mutation for the autoinflammatory disease hyper IgD syndrome, show opposite phenotypes, that is, the first being asymptomatic, the second presenting all classical characteristics of the disease. METHODS: Where single omics (mainly exome) analysis fails to identify culprit genes/mutations in human complex diseases, multiomics analyses may provide solutions, although this has been seldom used in a clinical setting...
July 20, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30030261/response-to-is-mir200b-5p-a-new-predictor-of-lymphoma-or-associated-with-lymphocytes-infiltrate-within-salivary-glands-by-nocturne-et-al
#4
Efstathia K Kapsogeorgou, Aristea Papageorgiou, Athanase D Protogerou, Michael Voulgarelis, Athanasios G Tzioufas
No abstract text is available yet for this article.
July 20, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30026257/single-cell-rna-seq-analysis-reveals-the-progression-of-human-osteoarthritis
#5
Quanbo Ji, Yuxuan Zheng, Guoqiang Zhang, Yuqiong Hu, Xiaoying Fan, Yu Hou, Lu Wen, Li Li, Yameng Xu, Yan Wang, Fuchou Tang
OBJECTIVES: Understanding the molecular mechanisms underlying human cartilage degeneration and regeneration is helpful for improving therapeutic strategies for treating osteoarthritis (OA). Here, we report the molecular programmes and lineage progression patterns controlling human OA pathogenesis using single-cell RNA sequencing (scRNA-seq). METHODS: We performed unbiased transcriptome-wide scRNA-seq analysis, computational analysis and histological assays on 1464 chondrocytes from 10 patients with OA undergoing knee arthroplasty surgery...
July 19, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30021804/photosensitivity-and-type-i-ifn-responses-in-cutaneous-lupus-are-driven-by-epidermal-derived-interferon-kappa
#6
Mrinal K Sarkar, Grace A Hile, Lam C Tsoi, Xianying Xing, Jianhua Liu, Yun Liang, Celine C Berthier, William R Swindell, Matthew T Patrick, Shuai Shao, Pei-Suen Tsou, Ranjitha Uppala, Maria A Beamer, Anshika Srivastava, Stephanie L Bielas, Paul W Harms, Spiro Getsios, James T Elder, John J Voorhees, Johann E Gudjonsson, J Michelle Kahlenberg
OBJECTIVE: Skin inflammation and photosensitivity are common in patients with cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE), yet little is known about the mechanisms that regulate these traits. Here we investigate the role of interferon kappa (IFN-κ) in regulation of type I interferon (IFN) and photosensitive responses and examine its dysregulation in lupus skin. METHODS: mRNA expression of type I IFN genes was analysed from microarray data of CLE lesions and healthy control skin...
July 18, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30021803/slit2-robo4-axis-may-contribute-to-endothelial-cell-dysfunction-and-angiogenesis-disturbance-in-systemic-sclerosis
#7
Eloisa Romano, Mirko Manetti, Irene Rosa, Bianca Saveria Fioretto, Lidia Ibba-Manneschi, Marco Matucci-Cerinic, Serena Guiducci
OBJECTIVE: In systemic sclerosis (SSc), early microvascular injury is followed by impaired angiogenesis and peripheral capillary loss. Here, we investigated the possible contribution of the neurovascular guidance molecule Slit2 and its Roundabout (Robo) receptors to SSc-related endothelial cell dysfunction. METHODS: Circulating Slit2 levels were measured in patients with SSc and healthy controls. Slit2, Robo1 and Robo4 expression was investigated in SSc and healthy skin biopsies and explanted dermal microvascular endothelial cells (MVECs)...
July 18, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30018071/clinical-associations-and-expression-pattern-of-the-autoimmunity-susceptibility-factor-diora-1-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#8
LETTER
Lara A Aqrawi, Lara Mentlein, Lauro Meneghel, Albin Björk, Gudny Ella Thorlacius, Margarita Ivanchenko, Jorge I Ramírez Sepúlveda, Kathrine Skarstein, Marika Kvarnström, Susanna Brauner, Alexander Espinosa, Marie Wahren-Herlenius
No abstract text is available yet for this article.
July 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30012643/increase-in-circulating-cells-coexpressing-m1-and-m2-macrophage-surface-markers-in-patients-with-systemic-sclerosis
#9
LETTER
Stefano Soldano, Amelia Chiara Trombetta, Paola Contini, Veronica Tomatis, Barbara Ruaro, Renata Brizzolara, Paola Montagna, Alberto Sulli, Sabrina Paolino, Carmen Pizzorni, Vanessa Smith, Maurizio Cutolo
No abstract text is available yet for this article.
July 16, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30007905/epidemiology-and-socioeconomic-impact-of-the-rheumatic-diseases-on-indigenous-people-an-invisible-syndemic-public-health-problem
#10
Ingris Peláez-Ballestas, Ysabel Granados, Rosana Quintana, Adalberto Loyola-Sánchez, Flor Julián-Santiago, Celenia Rosillo, Alfonso Gastelum-Strozzi, Jose Alvarez-Nemegyei, Natalia Santana, Adriana Silvestre, Cesar Pacheco-Tena, Mario Goñi, Conrado García-García, Ligia Cedeño, Bernardo A Pons-Éstel
Epidemiological studies in Latin America suggest indigenous people lack proper healthcare for musculoskeletal (MSK) and rheumatic diseases. OBJECTIVES: This study aimed to estimate the prevalence of MSK disorders and rheumatic diseases in eight Latin American indigenous communities, and to identify which factors influence such prevalence using network analysis and syndemic approach. METHODS: This is a cross-sectional, community-based census study according to Community-Oriented Program for the Control of Rheumatic Diseases methodology...
July 14, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30002086/response-to-the-use-of-dual-energy-ct-to-detect-and-depict-bone-marrow-oedema-in-rheumatoid-arthritis-is-it-ready-to-substitute-mri-by-wu-et-al
#11
Lennart Jans, Isabelle De Kock, Nele Herregods, Koenraad L Verstraete, Filip E Van den Bosch, Philippe Carron, Edwin H Oei, Dirk Elewaut, Peggy Jacques
No abstract text is available yet for this article.
July 12, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30002085/use-of-dual-energy-ct-to-detect-and-depict-bone-marrow-oedema-in-rheumatoid-arthritis-is-it-ready-to-substitute-mri
#12
LETTER
Haijun Wu, Guangfeng Zhang, Xiaoyu Huang, Changhong Liang
No abstract text is available yet for this article.
July 12, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29997113/apolipoprotein-b-binds-to-enolase-1-and-aggravates-inflammation-in-rheumatoid-arthritis
#13
Joo Youn Lee, Min Jueng Kang, Ji Yong Choi, Ji Soo Park, Jin Kyun Park, Eun Young Lee, Eun Bong Lee, Thomas Pap, Eugene C Yi, Yeong Wook Song
OBJECTIVE: Immune cells from patients with rheumatoid arthritis (RA) express more enolase-1 (ENO1) on their surface than those from healthy subjects, and they elicit an enhanced inflammatory response. This study is aimed to identify the ligands of ENO1 that could promote inflammatory loops in vitro and enhance the arthritis severity in vivo. METHODS: ENO1-binding proteins in RA synovial fluid were identified by mass spectromety, and affinity to ENO1 was evaluated by means of a ligand blotting and binding assay, surface plasmon resonance and confocal microscopy...
July 11, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29997112/2018-eular-recommendations-for-physical-activity-in-people-with-inflammatory-arthritis-and-osteoarthritis
#14
Anne-Kathrin Rausch Osthoff, Karin Niedermann, Jürgen Braun, Jo Adams, Nina Brodin, Hanne Dagfinrud, Tuncay Duruoz, Bente Appel Esbensen, Klaus-Peter Günther, Emailie Hurkmans, Carsten Bogh Juhl, Norelee Kennedy, Uta Kiltz, Keegan Knittle, Michael Nurmohamed, Sandra Pais, Guy Severijns, Thijs Willem Swinnen, Irene A Pitsillidou, Louise Warburton, Zhivko Yankov, Theodora P M Vliet Vlieland
Regular physical activity (PA) is increasingly promoted for people with rheumatic and musculoskeletal diseases as well as the general population. We evaluated if the public health recommendations for PA are applicable for people with inflammatory arthritis (iA; Rheumatoid Arthritis and Spondyloarthritis) and osteoarthritis (hip/knee OA) in order to develop evidence-based recommendations for advice and guidance on PA in clinical practice. The EULAR standardised operating procedures for the development of recommendations were followed...
July 11, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29997111/glucocorticoid-receptor-in-stromal-cells-is-essential-for-glucocorticoid-mediated-suppression-of-inflammation-in-arthritis
#15
Mascha Koenen, Stephan Culemann, Sabine Vettorazzi, Giorgio Caratti, Lucien Frappart, Wolfgang Baum, Gerhard Krönke, Ulrike Baschant, Jan P Tuckermann
BACKGROUND: Glucocorticoid (GC) therapy is frequently used to treat rheumatoid arthritis due to potent anti-inflammatory actions of GCs. Direct actions of GCs on immune cells were suggested to suppress inflammation. OBJECTIVES: Define the role of the glucocorticoid receptor (GR) in stromal cells for suppression of inflammatory arthritis. METHODS: Bone marrow chimeric mice lacking the GR in the hematopoietic or stromal compartment, respectively, and mice with impaired GR dimerisation (GRdim ) were analysed for their response to dexamethasone (DEX, 1 mg/kg) treatment in serum transfer-induced arthritis (STIA)...
July 11, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29997110/characterisation-of-the-nasal-microbiota-in-granulomatosis-with-polyangiitis
#16
Rennie L Rhee, Antoine G Sreih, Catherine E Najem, Peter C Grayson, Chunyu Zhao, Kyle Bittinger, Ronald G Collman, Peter A Merkel
OBJECTIVES: Prior studies have suggested a potential link between nasal microbes and granulomatosis with polyangiitis (GPA; Wegener's), but these studies relied on culture-dependent methods. This study comprehensively examined the entire community of nasal microbiota (bacteria and fungi) in participants with GPA compared with healthy controls using deep sequencing methods. METHODS: 16S rRNA and internal transcribed spacer gene sequencing were performed on nasal microbial DNA isolated from nasal swabs of 60 participants with GPA and 41 healthy controls...
July 11, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29991474/response-to-inconsistency-between-supplement-and-article-by-babaoglu-h
#17
Désirée van der Heijde, Natasha de Peyrecave, Tommi Nurminen
No abstract text is available yet for this article.
July 10, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29991473/synovial-macrophage-m1-polarisation-exacerbates-experimental-osteoarthritis-partially-through-r-spondin-2
#18
Haiyan Zhang, Chuangxin Lin, Chun Zeng, Zhenyu Wang, Hua Wang, Jiansen Lu, Xin Liu, Yan Shao, Chang Zhao, Jianying Pan, Song Xu, Yue Zhang, Denghui Xie, Daozhang Cai, Xiaochun Bai
OBJECTIVES: To investigate the roles and regulatory mechanisms of synovial macrophages and their polarisation in the development of osteoarthritis (OA). METHODS: Synovial tissues from normal patients and patients with OA were collected. M1 or M2-polarised macrophages in synovial tissues of patients with OA and OA mice were analysed by immunofluorescence and immunohistochemical staining. Mice with tuberous sclerosis complex 1 (TSC1) or Rheb deletion specifically in the myeloid lineage were generated and subjected to intra-articular injection of collagenase (collagenase-induced osteoarthritis, CIOA) and destabilisation of the medial meniscus (DMM) surgery to induce OA...
July 10, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29980577/tetraspanin-cd82-affects-migration-attachment-and-invasion-of-rheumatoid-arthritis-synovial-fibroblasts
#19
Elena Neumann, Maria C Schwarz, Rebecca Hasseli, Marie-Lisa Hülser, Simon Classen, Michael Sauerbier, Stefan Rehart, Ulf Mueller-Ladner
Tetraspanins function as membrane adaptors altering cell-cell fusion, antigen presentation, receptor-mediated signal transduction and cell motility via interaction with membrane proteins including other tetraspanins and adhesion molecules such as integrins. CD82 is expressed in several malignant cells and well described as tumour metastasis suppressor. Rheumatoid arthritis (RA) is based on persistent synovial inflammation and joint destruction driven to a large extent by transformed-appearing activated synovial fibroblasts (SF) with an increased migratory potential...
July 6, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29980576/inequity-in-access-to-bdmard-care-and-how-it-influences-disease-outcomes-across-countries-worldwide-results-from-the-meteor-registry
#20
Sytske Anne Bergstra, Jaime C Branco, David Vega-Morales, Karen Salomon-Escoto, Nimmisha Govind, Cornelia F Allaart, Robert B M Landewé
OBJECTIVE: To establish in a global setting the relationships between countries' socioeconomic status (SES), measured biological disease modifying antirheumatic drug (bDMARD)-usage and disease outcomes. To assess if prescription and reimbursement rules and generic access to medication relates to a countries' bDMARD-usage. METHODS: Data on disease activity and drug use from countries that had contributed at least 100 patients were extracted from the METEOR database...
July 6, 2018: Annals of the Rheumatic Diseases
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