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Annals of the Rheumatic Diseases

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https://www.readbyqxmd.com/read/30636215/decreased-chance-of-a-live-born-child-in-women-with-rheumatoid-arthritis-after-assisted-reproduction-treatment-a-nationwide-cohort-study
#1
Bente Mertz Nørgård, Michael Due Larsen, Sonia Friedman, Torben Knudsen, Jens Fedder
OBJECTIVES: No studies have examined the efficacy of assisted reproductive technology (ART) treatment in women with rheumatoid arthritis. Therefore, we examined the chance of live birth after ART treatment in women with rheumatoid arthritis compared with women without rheumatoid arthritis. METHODS: Our cohort study is based on nationwide Danish health registries, comprising all women with an embryo transfer during 1 January 1994 through 30 June 2017. The cohorts comprised 1149 embryo transfers in women with rheumatoid arthritis, and 198 941 embryo transfers in women without rheumatoid arthritis...
January 12, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30636214/jan-g%C3%A3-sta-waldenstr%C3%A3-m-and-rheumatology
#2
Frank A Wollheim
No abstract text is available yet for this article.
January 12, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30636213/verna-wright-father-of-the-spondyloarthropathies
#3
Philip S Helliwell
No abstract text is available yet for this article.
January 12, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30636212/current-challenges-in-the-development-of-new-treatments-for-lupus
#4
Maria Dall'Era, Ian N Bruce, Caroline Gordon, Susan Manzi, Janis McCaffrey, Peter E Lipsky
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a considerable impact on patients' quality of life. Despite the plethora of clinical trials for SLE since the turn of the millennium, only one new treatment has been approved for the condition, and the overall pace of successful drug development remains slow. Nevertheless, the myriad of clinical studies has yielded insights that have informed and refined our understanding of eligibility criteria, outcome measures and trial design in SLE...
January 12, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30626658/association-of-synovial-tissue-polyfunctional-t-cells-with-dapsa-in-psoriatic-arthritis
#5
Sarah M Wade, Mary Canavan, Trudy McGarry, Candice Low, Siobhan C Wade, Ronan H Mullan, Douglas J Veale, Ursula Fearon
OBJECTIVE: This study examines polyfunctional T-cells in psoriatic arthritis (PsA) synovial tissue and their associations with clinical disease and implications for therapy. METHODS: PsA synovial tissue was enzymatically/mechanically digested to generate synovial tissue single cell suspensions. Frequencies of polyfunctional CD4, CD8, T-helper 1 (Th1), Th17 and exTh17 cells, using CD161 as a marker of Th17 plasticity, were determined by flow cytometry in matched PsA synovial tissue and peripheral blood...
January 9, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30626657/derivation-and-validation-of-the-sle-disease-activity-score-sle-das-a-new-sle-continuous-measure-with-high-sensitivity-for-changes-in-disease-activity
#6
Diogo Jesus, Ana Matos, Carla Henriques, Margherita Zen, Maddalena Larosa, Luca Iaccarino, José António Pereira Da Silva, Andrea Doria, Luís Sousa Inês
OBJECTIVES: To derive and validate a new disease activity measure for systemic lupus erythematosus (SLE), the SLE Disease Activity Score (SLE-DAS), with improved sensitivity to change as compared with SLE Disease Activity Index (SLEDAI), while maintaining high specificity and easiness of use. METHODS: We studied 520 patients with SLE from two tertiary care centres (derivation and validation cohorts). At each visit, disease activity was scored using the Physician Global Assessment (PGA) and SLEDAI 2000 (SLEDAI-2K)...
January 9, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30612119/iga-vasculitis-in-adults-few-certainties-and-many-uncertainties
#7
Alojzija Hočevar, Matija Tomšič, Žiga Rotar
No abstract text is available yet for this article.
January 5, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30612118/molecular-profile-and-proangiogenic-activity-of-the-adipose-derived-stromal-vascular-fraction-used-as-an-autologous-innovative-medicinal-product-in-patients-with-systemic-sclerosis
#8
Jérémy Magalon, Mélanie Velier, Stéphanie Simoncini, Pauline François, Baptiste Bertrand, Aurélie Daumas, Audrey Benyamine, Romain Boissier, Laurent Arnaud, Luc Lyonnet, Samantha Fernandez, Françoise Dignat-George, Dominique Casanova, Benjamin Guillet, Brigitte Granel, Pascale Paul, Florence Sabatier
OBJECTIVE: The autologous stromal vascular fraction (SVF) from adipose tissue is an alternative to cultured adipose-derived stem cells for use in regenerative medicine and represents a promising therapy for vasculopathy and hand disability in systemic sclerosis (SSc). However, the bioactivity of autologous SVF is not documented in this disease context. This study aimed to compare the molecular and functional profiles of the SVF-based medicinal product obtained from SSc and healthy subjects...
January 5, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30612117/clinical-phenotypes-of-igg4-related-disease-an-analysis-of-two-international-cross-sectional-cohorts
#9
Zachary S Wallace, Yuqing Zhang, Cory A Perugino, Ray Naden, Hyon K Choi, John H Stone
OBJECTIVE: IgG4-related disease (IgG4-RD) is a heterogeneous, multiorgan condition of unclear aetiology that can cause organ failure. Difficulty recognising IgG4-RD contributes to diagnostic delays. We sought to identify key IgG4-RD phenotypes. METHODS: We used two cross-sectional studies assembled by an international, multispecialty network of IgG4-RD specialists who submitted 765 cases to derive and replicate phenotypic groups. Phenotype groups of disease manifestations and key covariate distributions across the identified groups were measured using latent class analysis...
January 5, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30612116/mycophenolate-mofetil-versus-cyclophosphamide-for-remission-induction-in-anca-associated-vasculitis-a-randomised-non-inferiority-trial
#10
Rachel B Jones, Thomas F Hiemstra, Jose Ballarin, Daniel Engelbert Blockmans, Paul Brogan, Annette Bruchfeld, Maria C Cid, Karen Dahlsveen, Janak de Zoysa, Georgína Espigol-Frigolé, Peter Lanyon, Chen Au Peh, Vladimir Tesar, Augusto Vaglio, Michael Walsh, Dorothy Walsh, Giles Walters, Lorraine Harper, David Jayne
OBJECTIVES: Cyclophosphamide induction regimens are effective for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), but are associated with infections, malignancies and infertility. Mycophenolate mofetil (MMF) has shown high remission rates in small studies of AAV. METHODS: We conducted a randomised controlled trial to investigate whether MMF was non-inferior to cyclophosphamide for remission induction in AAV. 140 newly diagnosed patients were randomly assigned to MMF or pulsed cyclophosphamide...
January 5, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30612115/risk-of-serious-infections-in-patients-with-rheumatoid-arthritis-treated-in-routine-care-with-abatacept-rituximab-and-tocilizumab-in-denmark-and-sweden
#11
Kathrine Lederballe Grøn, Elizabeth V Arkema, Bente Glintborg, Frank Mehnert, Mikkel Østergaard, Lene Dreyer, Mette Nørgaard, Niels Steen Krogh, Johan Askling, Merete Lund Hetland
OBJECTIVE: To estimate (1) crude and age-and gender-adjusted incidence rates (IRs) of serious infections (SI) and (2) relative risks (RR) of SI in patients with rheumatoid arthritis (RA) initiating treatment with abatacept, rituximab or tocilizumab in routine care. METHODS: This is an observational cohort study conducted in parallel in Denmark and Sweden including patients with RA in Denmark (DANBIO) and Sweden (Anti-Rheumatic Treatment in Sweden Register/Swedish Rheumatology Quality Register) who started abatacept/rituximab/tocilizumab in 2010-2015...
January 5, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30610068/-to-switch-or-not-to-switch-the-missing-piece-in-the-puzzle-of-biosimilar-literature
#12
Marc Scherlinger, Thierry Schaeverbeke
No abstract text is available yet for this article.
January 4, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30610067/effect-of-a-treat-to-target-intervention-of-cardiovascular-risk-factors-on-subclinical-and-clinical-atherosclerosis-in-rheumatoid-arthritis-a-randomised-clinical-trial
#13
Benjamin Burggraaf, Deborah F van Breukelen-van der Stoep, Marijke A de Vries, Boudewijn Klop, Anho H Liem, Gert-Jan M van de Geijn, Noelle van der Meulen, Erwin Birnie, Ellen M van der Zwan, Jende van Zeben, Manuel Castro Cabezas
BACKGROUND: Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease (CVD). No long-term intervention trials on CVD risk factors have been published, and a debate on the efficacy of controlling traditional risk factors in RA is ongoing. We aimed to evaluate a treat-to-target approach versus usual care regarding traditional CVD risk factors in patients with RA. METHODS: In this open-label, randomised controlled trial, patients with RA aged <70 years without prior CVD or diabetes mellitus were randomised 1:1 to either a treat-to-target approach or usual care of traditional CVD risk factors...
January 4, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30610066/organ-damage-in-patients-treated-with-belimumab-versus-standard-of-care-a-propensity-score-matched-comparative-analysis
#14
Murray B Urowitz, Robert L Ohsfeldt, Ronald C Wielage, Kari A Kelton, Yumi Asukai, Sulabha Ramachandran
OBJECTIVES: The study (206347) compared organ damage progression in patients with systemic lupus erythematosus (SLE) who received belimumab in the BLISS long-term extension (LTE) study with propensity score (PS)-matched patients treated with standard of care (SoC) from the Toronto Lupus Cohort (TLC). METHODS: A systematic literature review identified 17 known predictors of organ damage to calculate a PS for each patient. Patients from the BLISS LTE and the TLC were PS matched posthoc 1:1 based on their PS (±calliper)...
January 4, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30610065/validity-of-the-swedish-version-of-the-systemic-sclerosis-quality-of-life-questionnaire-sscqol-a-novel-measure-of-quality-of-life-for-patients-with-systemic-sclerosis
#15
Gunnel Sandqvist, Roger Hesselstrand
No abstract text is available yet for this article.
January 4, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30610064/rituximab-in-moderate-to-severe-non-renal-systemic-lupus-erythematosus-a-reanalysis-of-the-explorer-study
#16
Marc Scherlinger, Claire Carcaud, Marie-Elise Truchetet, Thomas Barnetche, Pierre Duffau, Lionel Couzi, Julien Seneschal, Patrick Blanco, Estibaliz Lazaro, Christophe Richez
No abstract text is available yet for this article.
January 4, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30610063/established-organ-damage-reduces-belimumab-efficacy-in-systemic-lupus-erythematosus
#17
Ioannis Parodis, Alvaro Gomez, Sharzad Emamikia, Katerina Chatzidionysiou
No abstract text is available yet for this article.
January 4, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30610062/response-to-effectiveness-of-low-dose-radiation-therapy-on-symptoms-in-patients-with-knee-osteoarthritis-by-wu-et-al
#18
Elien A M Mahler, Michiel J M Minten, Mathilde M Leseman-Hoogenboom, Philip M P Poortmans, Jan Willem H Leer, Simone S Boks, Frank H J van den Hoogen, Alfons A den Broeder, Cornelia Hm van den Ende
No abstract text is available yet for this article.
January 4, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30610061/critical-role-for-arginase-ii-in-osteoarthritis-pathogenesis
#19
Wan-Su Choi, Jeong-In Yang, Wihak Kim, Hyo-Eun Kim, Seul-Ki Kim, Yoonkyung Won, Young-Ok Son, Churl-Hong Chun, Jang-Soo Chun
OBJECTIVE: Osteoarthritis (OA) appears to be associated with various metabolic disorders, but the potential contribution of amino acid metabolism to OA pathogenesis has not been clearly elucidated. Here, we explored whether alterations in the amino acid metabolism of chondrocytes could regulate OA pathogenesis. METHODS: Expression profiles of amino acid metabolism-regulating genes in primary-culture passage 0 mouse chondrocytes were examined by microarray analysis, and selected genes were further characterised in mouse OA chondrocytes and OA cartilage of human and mouse models...
January 4, 2019: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30606740/evaluation-of-retinal-microvascular-perfusion-in-systemic-sclerosis-a-case-control-study
#20
Matthias Rothe, Felix Rommel, Sebastian Klapa, Jens Y Humrich, Relana Nieberding, Tanja Lange, Jan A M Sochurek, Pauline Plöttner, Salvatore Grisanti, Gabriela Riemekasten, Mahdy Ranjbar
No abstract text is available yet for this article.
January 3, 2019: Annals of the Rheumatic Diseases
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