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Annals of the Rheumatic Diseases

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https://www.readbyqxmd.com/read/28096072/response-to-eletter-infections-in-giant-cell-arteritis-and-therapeutic-implications-by-moiseev-et-al
#1
LETTER
Rennie L Rhee, Peter C Grayson, Peter A Merkel, Gunnar Tomasson
No abstract text is available yet for this article.
January 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28096071/clinical-benefit-of-vedolizumab-on-articular-manifestations-in-patients-with-active-spondyloarthritis-associated-with-inflammatory-bowel-disease
#2
LETTER
Ambrogio Orlando, Rosalba Orlando, Francesco Ciccia, Sara Renna, Aroldo Rizzo, Mario Cottone, Fabio Salvatore Macaluso
No abstract text is available yet for this article.
January 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28093419/the-risk-of-fracture-among-patients-with-psoriatic-arthritis-and-psoriasis-a-population-based-study
#3
Alexis Ogdie, Lauren Harter, Daniel Shin, Joshua Baker, Junko Takeshita, Hyon K Choi, Thorvardur Jon Love, Joel M Gelfand
OBJECTIVE: To determine the risk of fracture and osteoporosis among patients with psoriatic arthritis (PsA) and psoriasis, compared with the general population and patients with rheumatoid arthritis (RA). METHODS: A population-based cohort study was performed in The Health Improvement Network in the UK using data from 1994 to 2014. Patients aged 18-89 years with PsA or psoriasis and up to five unexposed controls matched by practice and start date within that practice were included...
January 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28093418/cell-specific-epigenome-wide-dna-methylation-profile-in-long-term-cultured-minor-salivary-gland-epithelial-cells-from-patients-with-sj%C3%A3-gren-s-syndrome
#4
Amandine Charras, Orsia D Konsta, Christelle Le Dantec, Cristina Bagacean, Efstathia K Kapsogeorgou, Athanasios G Tzioufas, Jacques-Olivier Pers, Anne Bordron, Yves Renaudineau
OBJECTIVES: The aetiology of primary Sjögren's syndrome (pSS), also referred to as autoimmune epithelitis, is incompletely understood but includes an epigenetic contribution. Accordingly, the aim of this study was to investigate DNA methylation in salivary gland epithelial cells (SGEC), and to compare results with those publicly available from pSS B and T cells. METHODS: Long-term cultured SGEC were selected to conduct an epigenome-wide association study (EWAS) in patients with pSS with comparison to controls using the HumanMethylation 450 K array from Illumina...
January 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28093417/cardiovascular-risk-of-patients-with-gout-seen-at-rheumatology-clinics-following-a-structured-assessment
#5
Mariano Andrés, José Antonio Bernal, Francisca Sivera, Neus Quilis, Loreto Carmona, Paloma Vela, Eliseo Pascual
OBJECTIVES: Gout-associated cardiovascular (CV) risk relates to comorbidities and crystal-led inflammation. The aim was to estimate the CV risk by prediction tools in new patients with gout and to assess whether ultrasonographic carotid changes are present in patients without high CV risk. METHODS: Cross-sectional study. Consecutive new patients with crystal-proven gout underwent a structured CV consultation, including CV events, risk factors and two risk prediction tools-the Systematic COronary Evaluation (SCORE) and the Framingham Heart Study (FHS)...
January 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28087507/response-to-does-inflammation-predict-radiographic-progression-in-hand-osteoarthritis-by-li-et-al
#6
LETTER
Alexander Mathiessen, Barbara Slatkowsky-Christensen, Tore K Kvien, Hilde Berner Hammer, Ida K Haugen
No abstract text is available yet for this article.
January 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28087506/a-randomised-phase-ii-study-evaluating-the-efficacy-and-safety-of-subcutaneously-administered-ustekinumab-and-guselkumab-in-patients-with-active-rheumatoid-arthritis-despite-treatment-with-methotrexate
#7
Josef S Smolen, Sandeep K Agarwal, Elena Ilivanova, Xie Lillian Xu, Ye Miao, Yanli Zhuang, Ivo Nnane, Waldemar Radziszewski, Andrew Greenspan, Anna Beutler, Daniel Baker
OBJECTIVE: Interleukin (IL)-12 and IL-23 have been implicated in the pathogenesis of rheumatoid arthritis (RA). The safety and efficacy of ustekinumab, a human monoclonal anti-IL-12/23 p40 antibody, and guselkumab, a human monoclonal anti-IL-23 antibody, were evaluated in adults with active RA despite methotrexate (MTX) therapy. METHODS: Patients were randomly assigned (1:1:1:1:1) to receive placebo at weeks 0, 4 and every 8 weeks (n=55), ustekinumab 90 mg at weeks 0, 4 and every 8 weeks (n=55), ustekinumab 90 mg at weeks 0, 4 and every 12 weeks (n=55), guselkumab 50 mg at weeks 0, 4 and every 8 weeks (n=55), or guselkumab 200 mg at weeks 0, 4 and every 8 weeks (n=54) through week 28; all patients continued a stable dose of MTX (10-25 mg/week)...
January 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28087505/2016-update-of-the-asas-eular-management-recommendations-for-axial-spondyloarthritis
#8
Désirée van der Heijde, Sofia Ramiro, Robert Landewé, Xenofon Baraliakos, Filip Van den Bosch, Alexandre Sepriano, Andrea Regel, Adrian Ciurea, Hanne Dagfinrud, Maxime Dougados, Floris van Gaalen, Pál Géher, Irene van der Horst-Bruinsma, Robert D Inman, Merryn Jongkees, Uta Kiltz, Tore K Kvien, Pedro M Machado, Helena Marzo-Ortega, Anna Molto, Victoria Navarro-Compàn, Salih Ozgocmen, Fernando M Pimentel-Santos, John Reveille, Martin Rudwaleit, Jochen Sieper, Percival Sampaio-Barros, Dieter Wiek, Jürgen Braun
To update and integrate the recommendations for ankylosing spondylitis and the recommendations for the use of tumour necrosis factor inhibitors (TNFi) in axial spondyloarthritis (axSpA) into one set applicable to the full spectrum of patients with axSpA. Following the latest version of the European League Against Rheumatism (EULAR) Standardised Operating Procedures, two systematic literature reviews first collected the evidence regarding all treatment options (pharmacological and non-pharmacological) that were published since 2009...
January 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28087504/does-inflammation-predict-radiographic-progression-in-hand-osteoarthritis
#9
LETTER
Hui Li, Hua Liu
No abstract text is available yet for this article.
January 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28073801/predictors-of-work-disability-after-start-of-anti-tnf-therapy-in-a-national-cohort-of-swedish-patients-with-rheumatoid-arthritis-does-early-anti-tnf-therapy-bring-patients-back-to-work
#10
T Olofsson, I F Petersson, J K Eriksson, M Englund, J A Nilsson, P Geborek, L T H Jacobsson, J Askling, M Neovius
OBJECTIVES: To examine predictors of work ability gain and loss after anti-tumour necrosis factor (TNF) start, respectively, in working-age patients with rheumatoid arthritis (RA) with a special focus on disease duration. METHODS: Patients with RA, aged 19-62 years, starting their first TNF inhibitor 2006-2009 with full work ability (0 sick leave/disability pension days during 3 months before bio-start; n=1048) or no work ability (90 days; n=753) were identified in the Swedish biologics register (Anti-Rheumatic Treatment In Sweden, ARTIS) and sick leave/disability pension days retrieved from the Social Insurance Agency...
January 10, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28073800/relationship-between-exposure-to-tumour-necrosis-factor-inhibitor-therapy-and-incidence-and-severity-of-myocardial-infarction-in-patients-with-rheumatoid-arthritis
#11
Audrey S L Low, Deborah P M Symmons, Mark Lunt, Louise K Mercer, Chris P Gale, Kath D Watson, William G Dixon, Kimme L Hyrich
OBJECTIVES: Patients with rheumatoid arthritis (RA) are at increased risk of myocardial infarction (MI) compared with subjects without RA, with the increased risk driven potentially by inflammation. Tumour necrosis factor inhibitors (TNFi) may modulate the risk and severity of MI. We compared the risk and severity of MI in patients treated with TNFi with that in those receiving synthetic disease-modifying antirheumatic drugs (sDMARDs). METHODS: This analysis included patients with RA recruited from 2001 to 2009 to the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis starting TNFi (etanercept/infliximab/adalimumab) and a biologic-naïve comparator cohort receiving sDMARD...
January 10, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28069577/mitochondrial-dna-haplogroups-and-ageing-mechanisms-in-osteoarthritis
#12
EDITORIAL
Ana M Valdes, Mary B Goldring
No abstract text is available yet for this article.
January 9, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28069576/dysbiosis-and-zonulin-upregulation-alter-gut-epithelial-and-vascular-barriers-in-patients-with-ankylosing-spondylitis
#13
Francesco Ciccia, Giuliana Guggino, Aroldo Rizzo, Riccardo Alessandro, Michele Maria Luchetti, Simon Milling, Laura Saieva, Heleen Cypers, Tommaso Stampone, Paola Di Benedetto, Armando Gabrielli, Alessio Fasano, Dirk Elewaut, Giovanni Triolo
BACKGROUND: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied. The aim of this study was to investigate the role of ileal bacteria in modulating local and systemic immune responses in AS. METHODS: Ileal biopsies were obtained from 50 HLA-B27(+) patients with AS and 20 normal subjects. Silver stain was used to visualise bacteria. Ileal expression of tight and adherens junction proteins was investigated by TaqMan real-time (RT)-PCR and immunohistochemistry...
January 9, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28062405/presence-of-multiple-spondyloarthritis-spa-features-is-important-but-not-sufficient-for-a-diagnosis-of-axial-spondyloarthritis-data-from-the-spondyloarthritis-caught-early-space-cohort
#14
Z Ez-Zaitouni, P A C Bakker, M van Lunteren, I J Berg, R Landewé, M van Oosterhout, M Lorenzin, D van der Heijde, F A van Gaalen
OBJECTIVES: Concerns have been raised about overdiagnosis of axial spondyloarthritis (axSpA). We investigated whether patients with chronic back pain (CBP) of short duration and multiple SpA features are always diagnosed with axSpA by the rheumatologist, and to what extent fulfilment of the Assessment of SpondyloArthritis International Society (ASAS) axSpA criteria is associated with an axSpA diagnosis. METHODS: Baseline data from 500 patients from the SPondyloArthritis Caught Early cohort which includes patients with CBP (≥3 months, ≤2 years, onset <45 years) were analysed...
January 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28062404/endothelial-to-mesenchymal-transition-contributes-to-endothelial-dysfunction-and-dermal-fibrosis-in-systemic-sclerosis
#15
Mirko Manetti, Eloisa Romano, Irene Rosa, Serena Guiducci, Silvia Bellando-Randone, Amato De Paulis, Lidia Ibba-Manneschi, Marco Matucci-Cerinic
OBJECTIVE: Systemic sclerosis (SSc) features multiorgan fibrosis orchestrated predominantly by activated myofibroblasts. Endothelial-to-mesenchymal transition (EndoMT) is a transdifferentiation by which endothelial cells (ECs) lose their specific morphology/markers and acquire myofibroblast-like features. Here, we determined the possible contribution of EndoMT to the pathogenesis of dermal fibrosis in SSc and two mouse models. METHODS: Skin sections were immunostained for endothelial CD31 or vascular endothelial (VE)-cadherin in combination with α-smooth muscle actin (α-SMA) myofibroblast marker...
January 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28057666/plasma-oxypurinol-as-a-measure-of-adherence-in-clinical-trials
#16
LETTER
Lisa K Stamp, Tony Merriman, Christopher Frampton, Mei Zhang, Mary Wallace, Jeffrey N Miner, Nicola Dalbeth
No abstract text is available yet for this article.
January 5, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28057665/giant-cell-arteritis-infections-and-biologics
#17
LETTER
Sergey Moiseev, Pavel Novikov, Ilya Smitienko, Elena Shchegoleva
No abstract text is available yet for this article.
January 5, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28052860/increased-prevalence-of-coronary-plaque-in-patients-with-psoriatic-arthritis-without-prior-diagnosis-of-coronary-artery-disease
#18
Jiayun Shen, Ka-Tak Wong, Isaac T Cheng, Qing Shang, Edmund K Li, Priscilla Wong, Emily W Kun, Mei Yan Law, Ronald Yip, Isaac Yim, Shirley Ying, Martin Li, Tena K Li, Chun-Kwok Wong, Tracy Y Zhu, Jack Jock-Wai Lee, Mimi Chang, Alex Pui-Wai Lee, Lai-Shan Tam
OBJECTIVES: To evaluate coronary atherosclerosis in patients with psoriatic arthritis (PsA) and control subjects using coronary CT angiography (CCTA). METHODS: Ninety consecutive patients with PsA (male: 56(62.2%); 50.3±11.1 years) were recruited. 240 controls (male: 137(57.1%); 49.6±10.7 years) without known cardiovascular (CV) diseases who underwent CCTA due to chest pain and/or multiple CV risk factors were recruited for comparison. RESULTS: Patients with PsA and controls were matched in age, gender and traditional CV risk factors (all p>0...
January 4, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28043999/response-to-autoinflammatory-disease-damage-index-addi-a-possible-newborn-also-in-hidradenitis-suppurativa-daily-practice-by-damiani-et-al
#19
LETTER
Kim V Annink, Nienke M Ter Haar, Joost Frenkel
No abstract text is available yet for this article.
January 2, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28043998/presence-of-anticitrullinated-protein-antibodies-in-a-large-population-based-cohort-from-the-netherlands
#20
A van Zanten, S Arends, C Roozendaal, P C Limburg, F Maas, L A Trouw, R E M Toes, T W J Huizinga, H Bootsma, E Brouwer
OBJECTIVES: To determine the prevalence of anticitrullinated protein antibodies (ACPAs) and their association with known rheumatoid arthritis (RA) risk factors in the general population. METHODS: Lifelines is a multidisciplinary prospective population-based cohort study in the Netherlands. Cross-sectional data from 40 136 participants were used. The detection of ACPA was performed by measuring anti-CCP2 on the Phadia-250 analyser with levels ≥6.2 U/mL considered positive...
January 2, 2017: Annals of the Rheumatic Diseases
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