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Annals of the Rheumatic Diseases

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https://www.readbyqxmd.com/read/28630236/european-evidence-based-recommendations-for-diagnosis-and-treatment-of-childhood-onset-systemic-lupus-erythematosus-the-share-initiative
#1
Noortje Groot, Nienke de Graeff, Tadej Avcin, Brigitte Bader-Meunier, Paul Brogan, Pavla Dolezalova, Brian Feldman, Isabelle Kone-Paut, Pekka Lahdenne, Stephen D Marks, Liza McCann, Seza Ozen, Clarissa Pilkington, Angelo Ravelli, Annet van Royen-Kerkhof, Yosef Uziel, Bas Vastert, Nico Wulffraat, Sylvia Kamphuis, Michael W Beresford
Childhood-onset systemic lupus erythematosus (cSLE) is a rare, multisystem and potentially life-threatening autoimmune disorder with significant associated morbidity. Evidence-based guidelines are sparse and management is often based on clinical expertise. SHARE (Single Hub and Access point for paediatric Rheumatology in Europe) was launched to optimise and disseminate management regimens for children and young adults with rheumatic diseases like cSLE. Here, we provide evidence-based recommendations for diagnosis and treatment of cSLE...
June 19, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28611082/a-population-based-cohort-study-of-rheumatoid-arthritis-associated-interstitial-lung-disease-comorbidity-and-mortality
#2
Charlotte Hyldgaard, Ole Hilberg, Alma Becic Pedersen, Sinna Pilgaard Ulrichsen, Anders Løkke, Elisabeth Bendstrup, Torkell Ellingsen
OBJECTIVES: To compare mortality risks in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and patients with RA without ILD. DESIGN: Matched cohort study. SETTING: The study was conducted in Denmark, using nationwide, prospectively collected data. PARTICIPANTS: Among patients with RA diagnosed between 2004 and 2016, 679 patients with RA-ILD were matched for birth year, gender and age at RA diagnosis with 11 722 patients with RA but without ILD MAIN OUTCOME MEASURES: Mortality risks were assessed using Kaplan-Meier mortality curves, and hazard rate ratios (HRRs) for death were estimated using Cox proportional hazards regression models...
June 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28611081/umbilical-cord-mesenchymal-stem-cells-for-the-treatment-of-autoimmune-diseases-beware-of-cell-to-cell-contact
#3
LETTER
Alessia Alunno, Onelia Bistoni, Pia Montanucci, Giuseppe Basta, Riccardo Calafiore, Roberto Gerli
No abstract text is available yet for this article.
June 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28611080/magnetic-resonance-imaging-assessed-inflammation-in-the-wrist-is-associated-with-patient-reported-physical-impairment-global-assessment-of-disease-activity-and-pain-in-early-rheumatoid-arthritis-longitudinal-results-from-two-randomised-controlled-trials
#4
Daniel Glinatsi, Joshua F Baker, Merete L Hetland, Kim Hørslev-Petersen, Bo J Ejbjerg, Kristian Stengaard-Pedersen, Peter Junker, Torkell Ellingsen, Hanne M Lindegaard, Ib Hansen, Tine Lottenburger, Jakob M Møller, Lykke Ørnbjerg, Aage Vestergaard, Anne Grethe Jurik, Henrik S Thomsen, Trine Torfing, Signe Møller-Bisgaard, Mette B Axelsen, Mikkel Østergaard
OBJECTIVES: To examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PROs). METHODS: Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTRA/OPERA) were assessed according to the Outcome Measures in Rheumatology RA MRI score (RAMRIS) for synovitis, tenosynovitis, osteitis, bone erosions and joint space narrowing (JSN) at baseline, 1 and 5 years follow-up...
June 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606971/response-to-does-il-38-act-on-macrophages-and-or-dendritic-cells-in-arthritis-by-jiang-et-al
#5
Marie-Astrid Boutet, Frédéric Blanchard, Benoît Le Goff
No abstract text is available yet for this article.
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606970/the-dynamics-of-response-as-measured-by-multiple-composite-outcome-tools-in-the-tight-control-of-inflammation-in-early-psoriatic-arthritis-ticopa-trial
#6
Laura C Coates, Farrouq Mahmood, Paul Emery, Philip G Conaghan, Philip S Helliwell
BACKGROUND: We aimed to evaluate the dynamics of treatment response with different composite measures in the TIght COntrol of inflammation in early Psoriatic Arthritis (TICOPA) trial. METHODS: Participants with early disease-modifying antirheumatic drug-naïve psoriatic arthritis (PsA) were randomised 1:1 to either tight control (TC; 4 weekly review with therapy escalation if criteria not met) or standard care (SC; 12 weekly review). We calculated modified versions of the Psoriatic ArthritiS Disease Activity Score (PASDAS), Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) Composite scorE (GRACE) and Composite Psoriatic Disease Activity Index (CPDAI) at baseline and 12 weekly to 48 weeks by blinded assessor...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606969/faecal-microbiota-study-reveals-specific-dysbiosis-in-spondyloarthritis
#7
Maxime Breban, Julien Tap, Ariane Leboime, Roula Said-Nahal, Philippe Langella, Gilles Chiocchia, Jean-Pierre Furet, Harry Sokol
OBJECTIVE: Altered microbiota composition or dysbiosis is suspected to be implicated in the pathogenesis of chronic inflammatory diseases, such as spondyloarthritis (SpA) and rheumatoid arthritis (RA). METHODS: 16S ribosomal RNA gene sequencing was performed on faecal DNA isolated from stool samples in two consecutive cross-sectional cohorts, each comprising three groups of adult volunteers: SpA, RA and healthy controls (HCs). In the second study, HCs comprised a majority of aged-matched siblings of patients with known HLA-B27 status...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606968/dendritic-cells-should-not-be-overlooked-when-studying-the-effect-of-il-38-administration-in-arthritis
#8
LETTER
Kuo Jiang, Yunshan Guo, Lin Xiao, Wenjie Pan, Jianbing Ma
No abstract text is available yet for this article.
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606967/anca-associated-vasculitis-mission-incomplete
#9
LETTER
Sergey V Moiseev, Pavel I Novikov, Ilya Smitienko
No abstract text is available yet for this article.
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606966/obesity-and-rates-of-clinical-remission-and-low-mri-inflammation-in-rheumatoid-arthritis
#10
Michael D George, Mikkel Østergaard, Philip G Conaghan, Paul Emery, Daniel G Baker, Joshua F Baker
OBJECTIVES: Obesity has been proposed as a risk factor for refractory rheumatoid arthritis (RA). We evaluated the impact of obesity on achieving clinical and imaging definitions of low disease activity. METHODS: This study evaluated 470 patients with RA from GO-BEFORE and GO-FORWARD randomised clinical trials. Included patients had blinded clinical disease activity measures and MRI at baseline, 24 and 52 weeks. Synovitis, osteitis and total inflammation scores were determined using the RA MRI scoring system...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606965/low-disease-activity-das28%C3%A2-3-2-reduces-the-risk-of-first-cardiovascular-event-in-rheumatoid-arthritis-a-time-dependent-cox-regression-analysis-in-a-large-cohort-study
#11
Elke Ea Arts, Jaap Fransen, Alfons A Den Broeder, Piet L C M van Riel, Calin D Popa
OBJECTIVE: Systemic inflammation appears to contribute to the excess risk of cardiovascular disease (CVD) in rheumatoid arthritis (RA). The objective of this study was to investigate the effect of different levels of disease activity over time, particularly low disease activity and remission, on CVD risk in patients with RA. METHODS: Data from the Nijmegen early RA inception cohort were used. The primary outcome was first CVD events within the first 10 years of follow-up...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606964/differences-in-the-symptomatic-phase-preceding-acpa-positive-and-acpa-negative-ra-a-longitudinal-study-in-arthralgia-during-progression-to-clinical-arthritis
#12
Leonie E Burgers, Hanna W van Steenbergen, Robin M Ten Brinck, Tom Wj Huizinga, Annette Hm van der Helm-van Mil
OBJECTIVE: Although anticitrullinated protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) have different aetiopathology, the clinical presentation at the time of diagnosis is similar. This study evaluated whether there are phenotypic differences in the symptomatic pre-RA phase. METHODS: Patients with arthralgia included in the Leiden clinically suspect arthralgia cohort who developed arthritis during follow-up were studied (n=67). Symptoms at symptom onset, symptoms and signs at presentation with arthralgia and time to arthritis development were compared between ACPA-positive and ACPA-negative patients...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606963/a-single-nucleotide-polymorphism-in-the-ncf1-gene-leading-to-reduced-oxidative-burst-is-associated-with-systemic-lupus-erythematosus
#13
Lina M Olsson, Åsa C Johansson, Birgitta Gullstrand, Andreas Jönsen, Saedis Saevarsdottir, Lars Rönnblom, Dag Leonard, Jonas Wetterö, Christopher Sjöwall, Elisabet Svenungsson, Iva Gunnarsson, Anders A Bengtsson, Rikard Holmdahl
OBJECTIVES: Ncf1 polymorphisms leading to low production of reactive oxygen species (ROS) are strongly associated with autoimmune diseases in animal models. The human NCF1 gene is very complex with both functional and non-functional gene copies and genotyping requires assays specific for functional NCF1 genes. We aimed at investigating association and function of the missense single nucleotide polymorphism (SNP), rs201802880 (here denoted NCF1-339) in NCF1 with systemic lupus erythematosus (SLE)...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606962/endothelin-1-promotes-vascular-smooth-muscle-cell-migration-across-the-artery-wall-a-mechanism-contributing-to-vascular-remodelling-and-intimal-hyperplasia-in-giant-cell-arteritis
#14
Ester Planas-Rigol, Nekane Terrades-Garcia, Marc Corbera-Bellalta, Ester Lozano, Marco A Alba, Marta Segarra, Georgina Espígol-Frigolé, Sergio Prieto-González, José Hernández-Rodríguez, Sara Preciado, Rodolfo Lavilla, Maria C Cid
BACKGROUND: Giant-cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries, frequently involving the temporal arteries (TA). Inflammation-induced vascular remodelling leads to vaso-occlusive events. Circulating endothelin-1 (ET-1) is increased in patients with GCA with ischaemic complications suggesting a role for ET-1 in vascular occlusion beyond its vasoactive function. OBJECTIVE: To investigate whether ET-1 induces a migratory myofibroblastic phenotype in human TA-derived vascular smooth muscle cells (VSMC) leading to intimal hyperplasia and vascular occlusion in GCA...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28606961/long-term-outcomes-after-disease-activity-guided-dose-reduction-of-tnf-inhibition-in-rheumatoid-arthritis-3-year-data-of-the-dress-study-a-randomised-controlled-pragmatic-non-inferiority-strategy-trial
#15
Chantal Am Bouman, Noortje van Herwaarden, Frank Hj van den Hoogen, Jaap Fransen, Ronald F van Vollenhoven, Johannes Wj Bijlsma, Aatke van der Maas, Alfons A den Broeder
OBJECTIVE: Tumour necrosis factor inhibitors (TNFi) are effective in rheumatoid arthritis (RA), but disadvantages include adverse events (AEs) and high costs. This can be improved by disease activity-guided dose reduction (DR). We aimed to assess long-term outcomes of TNFi DR in RA by using 3-year data from the DRESS study (Dose REduction Strategy of Subcutaneous TNF inhibitors study). METHODS: In the intervention phase (month 0-18) of the DRESS study (Dutch trial register, NTR 3216), patients were randomised to DR or usual care (UC)...
June 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28600350/rheumatoid-arthritis-and-polymyalgia-rheumatica-occurring-after-immune-checkpoint-inhibitor-treatment
#16
Rakiba Belkhir, Sébastien Le Burel, Laetitia Dunogeant, Aurélien Marabelle, Antoine Hollebecque, Benjamin Besse, Alexandra Leary, Anne-Laure Voisin, Clémence Pontoizeau, Laetitia Coutte, Edouard Pertuiset, Gaël Mouterde, Olivier Fain, Olivier Lambotte, Xavier Mariette
OBJECTIVES: Immune checkpoint inhibitors (ICIs) targeting cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 (PD-1) have demonstrated improved survival for multiple cancers. However, these new drug classes have led to increased immune-related adverse events (IrAE). Rheumatic IrAEs have not been well described in clinical trials. We report here cases of rheumatoid arthritis (RA) and polymyalgia rheumatica (PMR) occurring after ICI treatment. METHODS: This was a retrospective study of patients receiving an ICI in whom symptoms of arthritis or arthralgia developed and revealed a diagnosis of RA or PMR...
June 9, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28596185/response-to-quantifying-the-hepatotoxic-risk-of-alcohol-consumption-in-patients-with-rheumatoid-arthritis-by-kremer-and-weinblatt
#17
Jenny H Humphreys, Ruth Costello, Suzanne Mm Verstappen, William G Dixon
No abstract text is available yet for this article.
June 8, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28596184/quantifying-the-hepatotoxic-risk-of-alcohol-consumption-in-patients-with-rheumatoid-arthritis-taking-methotrexate
#18
LETTER
Joel M Kremer, Michael E Weinblatt
No abstract text is available yet for this article.
June 8, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28584189/the-efficacy-of-motivational-counselling-and-sms-reminders-on-daily-sitting-time-in-patients-with-rheumatoid-arthritis-a-randomised-controlled-trial
#19
Tanja Thomsen, Mette Aadahl, Nina Beyer, Merete Lund Hetland, Katrine Løppenthin, Julie Midtgaard, Robin Christensen, Mikkel Østergaard, Poul Jørgen Jennum, Bente Appel Esbensen
OBJECTIVES: The aim of this report is to investigate the efficacy of an individually tailored, theory-based behavioural intervention for reducing daily sitting time, pain and fatigue, as well as improving health-related quality of life, general self-efficacy, physical function and cardiometabolic biomarkers in patients with rheumatoid arthritis (RA). METHODS: In this randomised controlled trial 150 patients with RA were randomised to an intervention or a no-intervention control group...
June 5, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28584188/how-are-enthesitis-dactylitis-and-nail-involvement-measured-and-reported-in-recent-clinical-trials-of-psoriatic-arthritis-a-systematic-literature-review
#20
LETTER
Sofia Ramiro, Josef S Smolen, Robert Landewé, Désirée van der Heijde, Laure Gossec
No abstract text is available yet for this article.
June 5, 2017: Annals of the Rheumatic Diseases
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