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Annals of the Rheumatic Diseases

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https://www.readbyqxmd.com/read/28522454/multiomic-disease-signatures-converge-to-cytotoxic-cd8-t-cells-in-primary-sj%C3%A3-gren-s-syndrome
#1
Shinya Tasaki, Katsuya Suzuki, Ayumi Nishikawa, Yoshiaki Kassai, Maiko Takiguchi, Rina Kurisu, Yuumi Okuzono, Takahiro Miyazaki, Masaru Takeshita, Keiko Yoshimoto, Hidekata Yasuoka, Kunihiro Yamaoka, Kazuhiro Ikeura, Kazuyuki Tsunoda, Rimpei Morita, Akihiko Yoshimura, Hiroyoshi Toyoshiba, Tsutomu Takeuchi
OBJECTIVES: Multiomics study was conducted to elucidate the crucial molecular mechanisms of primary Sjögren's syndrome (SS) pathology. METHODS: We generated multiple data set from well-defined patients with SS, which includes whole-blood transcriptomes, serum proteomes and peripheral immunophenotyping. Based on our newly generated data, we performed an extensive bioinformatic investigation. RESULTS: Our integrative analysis identified SS gene signatures (SGS) dysregulated in widespread omics layers, including epigenomes, mRNAs and proteins...
May 18, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28522453/classification-and-diagnostic-criteria-in-sj%C3%A3-gren-s-syndrome-a-long-standing-and-still-open-controversy
#2
EDITORIAL
Claudio Vitali, Nicoletta Del Papa
No abstract text is available yet for this article.
May 18, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28522452/arthroscopic-partial-meniscectomy-versus-placebo-surgery-for-a-degenerative-meniscus-tear-a-2-year-follow-up-of-the-randomised-controlled-trial
#3
Raine Sihvonen, Mika Paavola, Antti Malmivaara, Ari Itälä, Antti Joukainen, Heikki Nurmi, Juha Kalske, Anna Ikonen, Timo Järvelä, Tero Ah Järvinen, Kari Kanto, Janne Karhunen, Jani Knifsund, Heikki Kröger, Tommi Kääriäinen, Janne Lehtinen, Jukka Nyrhinen, Juha Paloneva, Outi Päiväniemi, Marko Raivio, Janne Sahlman, Roope Sarvilinna, Sikri Tukiainen, Ville-Valtteri Välimäki, Ville Äärimaa, Pirjo Toivonen, Teppo Ln Järvinen
OBJECTIVE: To assess if arthroscopic partial meniscectomy (APM) is superior to placebo surgery in the treatment of patients with degenerative tear of the medial meniscus. METHODS: In this multicentre, randomised, participant-blinded and outcome assessor-blinded, placebo-surgery controlled trial, 146 adults, aged 35-65 years, with knee symptoms consistent with degenerative medial meniscus tear and no knee osteoarthritis were randomised to APM or placebo surgery. The primary outcome was the between-group difference in the change from baseline in the Western Ontario Meniscal Evaluation Tool (WOMET) and Lysholm knee scores and knee pain after exercise at 24 months after surgery...
May 18, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28522451/ada2-deficiency-dada2-as-an-unrecognised-cause-of-early-onset-polyarteritis-nodosa-and-stroke-a-multicentre-national-study
#4
Roberta Caorsi, Federica Penco, Alice Grossi, Antonella Insalaco, Alessia Omenetti, Maria Alessio, Giovanni Conti, Federico Marchetti, Paolo Picco, Alberto Tommasini, Silvana Martino, Clara Malattia, Romina Gallizi, Rosa Anna Podda, Annalisa Salis, Fernanda Falcini, Francesca Schena, Francesca Garbarino, Alessia Morreale, Manuela Pardeo, Claudia Ventrici, Chiara Passarelli, Qing Zhou, Mariasavina Severino, Carlo Gandolfo, Gianluca Damonte, Alberto Martini, Angelo Ravelli, Ivona Aksentijevich, Isabella Ceccherini, Marco Gattorno
OBJECTIVES: To analyse the prevalence of CECR1 mutations in patients diagnosed with early onset livedo reticularis and/or haemorrhagic/ischaemic strokes in the context of inflammation or polyarteritis nodosa (PAN). Forty-eight patients from 43 families were included in the study. METHODS: Direct sequencing of CECR1 was performed by Sanger analysis. Adenosine deaminase 2 (ADA2) enzymatic activity was analysed in monocyte isolated from patients and healthy controls incubated with adenosine and with or without an ADA1 inhibitor...
May 18, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28507219/subcutaneous-golimumab-for-children-with-active-polyarticular-course-juvenile-idiopathic-arthritis-results-of-a-multicentre-double-blind-randomised-withdrawal-trial
#5
Hermine I Brunner, Nicolino Ruperto, Nikolay Tzaribachev, Gerd Horneff, Vyacheslav G Chasnyk, Violeta Panaviene, Carlos Abud-Mendoza, Andreas Reiff, Ekaterina Alexeeva, Nadina Rubio-Pérez, Vladimir Keltsev, Daniel J Kingsbury, Maria Del Rocio Maldonado Velázquez, Irina Nikishina, Earl D Silverman, Rik Joos, Elzbieta Smolewska, Márcia Bandeira, Kirsten Minden, Annet van Royen-Kerkhof, Wolfgang Emminger, Ivan Foeldvari, Bernard R Lauwerys, Flavio Sztajnbok, Keith E Gilmer, Zhenhua Xu, Jocelyn H Leu, Lilianne Kim, Sarah L Lamberth, Matthew J Loza, Daniel J Lovell, Alberto Martini
OBJECTIVE: This report aims to determine the safety, pharmacokinetics (PK) and efficacy of subcutaneous golimumab in active polyarticular-course juvenile idiopathic arthritis (polyJIA). METHODS: In this three-part randomised double-blinded placebo-controlled withdrawal trial, all patients received open-label golimumab (30 mg/m(2) of body surface area; maximum: 50 mg/dose) every 4 weeks together with weekly methotrexate during Part 1 (weeks 0-16). Patients with at least 30% improvement per American College of Rheumatology Criteria for JIA (JIA ACR30) in Part 1 entered the double-blinded Part 2 (weeks 16-48) after 1:1 randomisation to continue golimumab or start placebo...
May 15, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28501801/a-rare-coding-allele-in-ifih1-is-protective-for-psoriatic-arthritis
#6
Ashley Budu-Aggrey, John Bowes, Philip E Stuart, Matthew Zawistowski, Lam C Tsoi, Rajan Nair, Deepak Rohit Jadon, Neil McHugh, Eleanor Korendowych, James T Elder, Anne Barton, Soumya Raychaudhuri
OBJECTIVES: Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. While many common risk alleles have been reported for association with PsA as well as psoriasis, few rare coding alleles have yet been identified. METHODS: To identify rare coding variation associated with PsA risk or protection, we genotyped 41 267 variants with the exome chip and investigated association within an initial cohort of 1980 PsA cases and 5913 controls. Genotype data for an independent cohort of 2234 PsA cases and 5708 controls was also made available, allowing for a meta-analysis to be performed with the discovery dataset...
May 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28501800/ustekinumab-inhibits-th1-and-th17-polarisation-in-a-patient-with-giant-cell-arteritis
#7
LETTER
Maxime Samson, Thibault Ghesquière, Sabine Berthier, Bernard Bonnotte
No abstract text is available yet for this article.
May 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28501799/high-maternal-expression-of-siglec1-on-monocytes-as-a-surrogate-marker-of-a-type-i-interferon-signature-is-a-risk-factor-for-the-development-of-autoimmune-congenital-heart-block
#8
Anna R Lisney, Franziska Szelinski, Karin Reiter, Gerd R Burmester, Thomas Rose, Thomas Dörner
OBJECTIVES: Autoimmune congenital heart block (CHB) is associated with placental transcytosis of maternal autoantibodies directed against Ro/SS-A and La/SS-B. However, only about 2% of children born to mothers with the respective antibodies are affected, indicating that further risk factors exist, which are not yet fully understood. In this study, we investigated whether a maternal type I interferon (IFN) signature represents a risk factor for the development of CHB. METHODS: Blood samples, clinical data and serological parameters from 9 women with CHB pregnancies, 14 pregnant women with antibodies against Ro/SS-A but without a CHB complication and another 30 healthy pregnant women as controls were studied...
May 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28500058/response-to-hla-a-31-01-is-not-associated-with-the-development-of-methotrexate-pneumonitis-in-the-uk-population-results-from-a-genome-wide-association-study-by-bluett-et-al
#9
Hiroshi Furukawa, Shomi Oka, Kota Shimada, Naoyuki Tsuchiya, Shigeto Tohma
No abstract text is available yet for this article.
May 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28500057/hla-a-31-01-is-not-associated-with-the-development-of-methotrexate-pneumonitis-in-the-uk-population-results-from-a-genome-wide-association-study
#10
LETTER
James Bluett, Sally-Ann Owen, Jonathan Massey, Ana Alfirevic, Munir Pirmohamed, Darren Plant, Suzanne M M Verstappen, Anne Barton
No abstract text is available yet for this article.
May 12, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28495672/elevated-serum-levels-of-sonic-hedgehog-are-associated-with-fibrotic-and-vascular-manifestations-in-systemic-sclerosis
#11
LETTER
Christian Beyer, Dörte Huscher, Andreas Ramming, Christina Bergmann, Jerome Avouac, Serena Guiducci, Florian Meier, Serena Vettori, Elise Siegert, Veronika K Jaeger, Britta Maurer, Gabriela Riemekasten, Ulrich Walker, Ulf Müller-Ladner, Gabriele Valentini, Marco Matucci-Cerinic, Yannick Allanore, Oliver Distler, Georg Schett, Jörg H W Distler
No abstract text is available yet for this article.
May 11, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28487313/knee-extensor-strength-and-body-weight-in-adolescent-men-and-the-risk-of-knee-osteoarthritis-by-middle-age
#12
Aleksandra Turkiewicz, Simon Timpka, Jonas Bloch Thorlund, Eva Ageberg, Martin Englund
OBJECTIVES: To assess the extent to which knee extensor strength and weight in adolescence are associated with knee osteoarthritis (OA) by middle age. METHODS: We studied a cohort of 40 121 men who at age 18 years in 1969/1970 underwent mandatory conscription in Sweden. We retrieved data on isometric knee extensor strength, weight, height, smoking, alcohol consumption, parental education and adult occupation from Swedish registries. We identified participants diagnosed with knee OA or knee injury from 1987 to 2010 through the National Patient Register...
May 9, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28483768/serious-adverse-events-and-the-risk-of-stroke-in-patients-with-rheumatoid-arthritis-results-from-the-german-rabbit-cohort
#13
Y Meissner, A Richter, B Manger, H P Tony, E Wilden, J Listing, A Zink, A Strangfeld
OBJECTIVE: In the general population, the incidence of stroke is increased following other serious events and hospitalisation. We investigated the impact of serious adverse events on the risk of stroke in patients with rheumatoid arthritis (RA), taking risk factors and treatment into account. METHODS: Using data of the German biologics register RABBIT (Rheumatoid Arthritis: Observation of Biologic Therapy) with 12354 patients with RA, incidence rates (IRs) and risk factors for stroke were investigated using multi-state and Cox proportional hazard models...
May 8, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28483767/incidence-and-prevalence-of-psoriatic-arthritis-in-denmark-a-nationwide-register-linkage-study
#14
Alexander Egeberg, Lars Erik Kristensen, Jacob P Thyssen, Gunnar Hilmar Gislason, Alice B Gottlieb, Laura C Coates, Denis Jullien, Paolo Gisondi, Dafna D Gladman, Lone Skov, Lotus Mallbris
OBJECTIVES: To examine the incidence and temporal trends of psoriatic arthritis (PsA) in the general population in Denmark. METHODS: Using nationwide registry data, we estimated the number of patients with incident PsA within each 1-year period between 1997 and 2011 and calculated the rate of PsA cases within gender and age subgroups. Incidence rates were presented per 100 000 person-years. RESULTS: There was a female predominance ranging from 50...
May 8, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28478402/response-to-2016-update-of-the-eular-recommendations-for-the-management-of-rheumatoid-arthritis-no-utopia-for-patients-in-low-middle-income-countries-by-misra-et-al
#15
Josef S Smolen, Robert B M Landewé, Désirée van der Heijde
No abstract text is available yet for this article.
May 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28478401/jak1-dependent-transphosphorylation-of-jak2-limits-the-antifibrotic-effects-of-selective-jak2-inhibitors-on-long-term-treatment
#16
Yun Zhang, Ruifang Liang, Chih-Wei Chen, Tatjana Mallano, Clara Dees, Alfiya Distler, Adam Reich, Christina Bergmann, Andreas Ramming, Kolja Gelse, Dirk Mielenz, Oliver Distler, Georg Schett, Jörg H W Distler
OBJECTIVES: Janus kinase 2 (JAK2) has recently been described as a novel downstream mediator of the pro-fibrotic effects of transforming growth factor-β. Although JAK2 inhibitors are in clinical use for myelodysplastic syndromes, patients often rapidly develop resistance. Tumour cells can escape the therapeutic effects of selective JAK2 inhibitors by mutation-independent transactivation of JAK2 by JAK1. Here, we used selective JAK2 inhibition as a model to test the hypothesis that chronic treatment may provoke resistance by facilitating non-physiological signalling pathways in fibroblasts...
May 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28478400/application-of-the-2015-2016-eular-recommendations-for-cardiovascular-risk-in-daily-practice-data-from-an-observational-study
#17
LETTER
Claire Immediato Daïen, Amandine Tubery, Guilhem du Cailar, Thibault Mura, François Roubille, Jacques Morel, Jean Bousquet, Pierre Fesler, Bernard Combe
No abstract text is available yet for this article.
May 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28478399/a-randomised-double-blind-placebo-controlled-trial-of-allogeneic-umbilical-cord-derived-mesenchymal-stem-cell-for-lupus-nephritis
#18
DanQi Deng, Peilian Zhang, Yun Guo, Teck Onn Lim
OBJECTIVE: We evaluate the efficacy of human umbilical cord-derived mesenchymal stem cell (hUC-MSC) for the treatment of lupus nephritis (LN). Previous reports showed hUC-MSC could have dramatic treatment effect. METHODS: Eighteen patients with WHO class III or IV LN were randomly assigned to hUC-MSC (dose 2×10(8) cells) or placebo. All patients received standard immunosuppressive treatment, which consisted of intravenous methylprednisolone and cyclophosphamide, followed by maintenance oral prednisolone and mycophenolate mofetil...
May 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28476880/eular-recommendations-for-management-of-fibromyalgia
#19
Gary J Macfarlane, Caroline Kronisch, Fabiola Atzeni, Winfried Häuser, Ernest H Choy, Kirstine Amris, Jaime Branco, Fitnat Dincer, Paivi Leino-Arjas, Kathy Longley, Geraldine McCarthy, Suzi Makri, Serge Perrot, Piercarlo Sarzi Puttini, Ann Taylor, Gareth T Jones
No abstract text is available yet for this article.
May 5, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28476879/eplerenone-treatment-alleviates-the-development-of-joint-lesions-in-a-new-rat-model-of-spontaneous-metabolic-associated-osteoarthritis
#20
LETTER
Chaohua Deng, Arnaud Bianchi, Nathalie Presle, David Moulin, Meriem Koufany, Cécile Guillaume, Hervé Kempf, Anne Pizard
No abstract text is available yet for this article.
May 5, 2017: Annals of the Rheumatic Diseases
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