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Annals of the Rheumatic Diseases

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https://www.readbyqxmd.com/read/29331963/response-to-standard-dose-of-ustekinumab-for-childhood-onset-deficiency-of-interleukin-36-receptor-antagonist-by-cherqaoui-et-al
#1
Nadia Bonekamp, Roberta Caorsi, Joost Frenkel, Marco Gattorno
No abstract text is available yet for this article.
January 13, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29331962/splicing-variant-of-wdfy4-augments-mda5-signalling-and-the-risk-of-clinically-amyopathic-dermatomyositis
#2
Yuta Kochi, Yoichiro Kamatani, Yuya Kondo, Akari Suzuki, Eiryo Kawakami, Ryosuke Hiwa, Yukihide Momozawa, Manabu Fujimoto, Masatoshi Jinnin, Yoshiya Tanaka, Takashi Kanda, Robert G Cooper, Hector Chinoy, Simon Rothwell, Janine A Lamb, Jiří Vencovský, Heřman Mann, Koichiro Ohmura, Keiko Myouzen, Kazuyoshi Ishigaki, Ran Nakashima, Yuji Hosono, Hiroto Tsuboi, Hidenaga Kawasumi, Yukiko Iwasaki, Hiroshi Kajiyama, Tetsuya Horita, Mariko Ogawa-Momohara, Akito Takamura, Shinichiro Tsunoda, Jun Shimizu, Keishi Fujio, Hirofumi Amano, Akio Mimori, Atsushi Kawakami, Hisanori Umehara, Tsutomu Takeuchi, Hajime Sano, Yoshinao Muro, Tatsuya Atsumi, Toshihide Mimura, Yasushi Kawaguchi, Tsuneyo Mimori, Atsushi Takahashi, Michiaki Kubo, Hitoshi Kohsaka, Takayuki Sumida, Kazuhiko Yamamoto
OBJECTIVES: Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases in which both genetic and environmental factors play important roles. To identify genetic factors of IIM including polymyositis, dermatomyositis (DM) and clinically amyopathic DM (CADM), we performed the first genome-wide association study for IIM in an Asian population. METHODS: We genotyped and tested 496 819 single nucleotide polymorphism for association using 576 patients with IIM and 6270 control subjects...
January 13, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29321158/response-to-calprotectin-is-not-independent-from-baseline-erosion-in-predicting-radiological-progression-in-early-rheumatoid-arthritis-by-chevreau-et-al
#3
Maria Karolina Jonsson, Nina Paulshus Sundlisæter, Hilde Haugedal Nordal, Hilde Berner Hammer, Anna-Birgitte Aga, Désirée van der Heijde, Tore Kristian Kvien, Bjørg-Tilde Svanes Fevang, Siri Lillegraven, Espen Andre Haavardsholm
No abstract text is available yet for this article.
January 10, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29321157/calprotectin-is-not-independent-from-baseline-erosion-in-predicting-radiological-progression-in-early-rheumatoid-arthritis-comment-on-calprotectin-as-a-marker-of-inflammation-in-patients-with-early-rheumatoid-arthritis-by-jonsson-et-al
#4
LETTER
Maxime Chevreau, Marie-Hélène Paclet, Xavier Romand, Jean-Louis Quesada, Olivier Vittecoq, Philippe Dieudé, Bertrand Toussaint, Philippe Gaudin, Athan Baillet
No abstract text is available yet for this article.
January 10, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29317407/a20-haploinsufficiency-ha20-clinical-phenotypes-and-disease-course-of-patients-with-a-newly-recognised-nf-kb-mediated-autoinflammatory-disease
#5
Florence A Aeschlimann, Ezgi D Batu, Scott W Canna, Ellen Go, Ahmet Gül, Patrycja Hoffmann, Helen L Leavis, Seza Ozen, Daniella M Schwartz, Deborah L Stone, Annet van Royen-Kerkof, Daniel L Kastner, Ivona Aksentijevich, Ronald M Laxer
OBJECTIVES: The association between mutations in TNFAIP3, encoding the NF-kB regulatory protein A20, and a new autoinflammatory disease has recently been recognised. This study aims at describing the clinical phenotypes and disease course of patients with A20 haploinsufficiency (HA20). METHODS: Data for all cases from the initial publication, and additional cases identified through collaborations since, were collected using standardised data collection forms. RESULTS: A total of 16 patients (13 female) from seven families with a genetic diagnosis of HA20 were included...
January 9, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29317406/response-to-performance-of-the-2017-european-league-against-rheumatism-american-college-of-rheumatology-classification-criteria-for-adult-and-juvenile-idiopathic-inflammatory-myopathies-in-clinical-practice-by-ho%C3%A4-evar-et-al
#6
https://www.readbyqxmd.com/read/29311148/protein-kinases-g-are-essential-downstream-mediators-of-the-antifibrotic-effects-of-sgc-stimulators
#7
Alexandru-Emil Matei, Christian Beyer, Andrea-Hermina Györfi, Alina Soare, Chih-Wei Chen, Clara Dees, Christina Bergmann, Andreas Ramming, Andreas Friebe, Franz Hofmann, Oliver Distler, Georg Schett, Jörg H W Distler
OBJECTIVES: Stimulators of soluble guanylate cyclase (sGC) are currently investigated in clinical trials for the treatment of fibrosis in systemic sclerosis (SSc). In this study, we aim to investigate the role of protein kinases G (PKG) as downstream mediators of sGC-cyclic guanosine monophosphate (cGMP) in SSc. METHODS: Mice with combined knockout of PKG1 and 2 were challenged with bleomycin and treated with the sGC stimulator BAY 41-2272. Fibroblasts were treated with BAY 41-2272 and with the PKG inhibitor KT 5823...
January 8, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29311147/remission-or-low-disease-activity-as-a-target-in-systemic-lupus-erythematosus
#8
LETTER
Manuel Francisco Ugarte-Gil, Daniel Wojdyla, Guillermo J Pons-Estel, Bernardo A Pons-Estel, Graciela S Alarcón
No abstract text is available yet for this article.
January 8, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29311146/impact-of-broad-regulatory-regions-on-gdf5-expression-and-function-in-knee-development-and-susceptibility-to-osteoarthritis
#9
Steve K Pregizer, Ata M Kiapour, Mariel Young, Hao Chen, Michael Schoor, Zun Liu, Jiaxue Cao, Vicki Rosen, Terence D Capellini
OBJECTIVES: Given the role of growth and differentiation factor 5 (GDF5) in knee development and osteoarthritis risk, we sought to characterise knee defects resulting from Gdf5 loss of function and how its regulatory regions control knee formation and morphology. METHODS: The brachypodism (bp) mouse line, which harbours an inactivating mutation in Gdf5, was used to survey how Gdf5 loss of function impacts knee morphology, while two transgenic Gdf5 reporter bacterial artificial chromosome mouse lines were used to assess the spatiotemporal activity and function of Gdf5 regulatory sequences in the context of clinically relevant knee anatomical features...
January 8, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29311145/depression-and-anxiety-associate-with-less-remission-after-1-year-in-rheumatoid-arthritis
#10
LETTER
Aleid C Boer, Tom W J Huizinga, Annette H M van der Helm-van Mil
No abstract text is available yet for this article.
January 8, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29306872/patterns-and-predictors-of-skin-score-change-in-early-diffuse-systemic-sclerosis-from-the-european-scleroderma-observational-study
#11
Ariane L Herrick, Sebastien Peytrignet, Mark Lunt, Xiaoyan Pan, Roger Hesselstrand, Luc Mouthon, Alan J Silman, Graham Dinsdale, Edith Brown, László Czirják, Jörg H W Distler, Oliver Distler, Kim Fligelstone, William J Gregory, Rachel Ochiel, Madelon C Vonk, Codrina Ancuţa, Voon H Ong, Dominique Farge, Marie Hudson, Marco Matucci-Cerinic, Alexandra Balbir-Gurman, Øyvind Midtvedt, Paresh Jobanputra, Alison C Jordan, Wendy Stevens, Pia Moinzadeh, Frances C Hall, Christian Agard, Marina E Anderson, Elisabeth Diot, Rajan Madhok, Mohammed Akil, Maya H Buch, Lorinda Chung, Nemanja S Damjanov, Harsha Gunawardena, Peter Lanyon, Yasmeen Ahmad, Kuntal Chakravarty, Søren Jacobsen, Alexander J MacGregor, Neil McHugh, Ulf Müller-Ladner, Gabriela Riemekasten, Michael Becker, Janet Roddy, Patricia E Carreira, Anne Laure Fauchais, Eric Hachulla, Jennifer Hamilton, Murat İnanç, John S McLaren, Jacob M van Laar, Sanjay Pathare, Susanna M Proudman, Anna Rudin, Joanne Sahhar, Brigitte Coppere, Christine Serratrice, Tom Sheeran, Douglas J Veale, Claire Grange, Georges-Selim Trad, Christopher P Denton
OBJECTIVES: Our aim was to use the opportunity provided by the European Scleroderma Observational Study to (1) identify and describe those patients with early diffuse cutaneous systemic sclerosis (dcSSc) with progressive skin thickness, and (2) derive prediction models for progression over 12 months, to inform future randomised controlled trials (RCTs). METHODS: The modified Rodnan skin score (mRSS) was recorded every 3 months in 326 patients. 'Progressors' were defined as those experiencing a 5-unit and 25% increase in mRSS score over 12 months (±3 months)...
January 6, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29306871/adalimumab-concentration-based-tapering-strategy-as-good-as-the-recommended-dosage
#12
EDITORIAL
Denis Mulleman, Alejandro Balsa
No abstract text is available yet for this article.
January 6, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29301783/2017-eular-recommendations-for-a-core-data-set-to-support-observational-research-and-clinical-care-in-rheumatoid-arthritis
#13
Helga Radner, Katerina Chatzidionysiou, Elena Nikiphorou, Laure Gossec, Kimme L Hyrich, Condruta Zabalan, Yvonne van Eijk-Hustings, Paula R Williamson, Andra Balanescu, Gerd R Burmester, Loreto Carmona, Maxime Dougados, Axel Finckh, Glenn Haugeberg, Merete Lund Hetland, Susan Oliver, Duncan Porter, Karim Raza, Patrick Ryan, Maria Jose Santos, Annette van der Helm-van Mil, Piet van Riel, Gabrielle von Krause, Jakub Zavada, William G Dixon, Johan Askling
Personalised medicine, new discoveries and studies on rare exposures or outcomes require large samples that are increasingly difficult for any single investigator to obtain. Collaborative work is limited by heterogeneities, both what is being collected and how it is defined. To develop a core set for data collection in rheumatoid arthritis (RA) research which (1) allows harmonisation of data collection in future observational studies, (2) acts as a common data model against which existing databases can be mapped and (3) serves as a template for standardised data collection in routine clinical practice to support generation of research-quality data...
January 4, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29295825/a-pivotal-phase-iii-randomised-placebo-controlled-study-of-belimumab-in-patients-with-systemic-lupus-erythematosus-located-in-china-japan-and-south-korea
#14
Fengchun Zhang, Sang-Cheol Bae, Damon Bass, Myron Chu, Sally Egginton, David Gordon, David A Roth, Jie Zheng, Yoshiya Tanaka
BACKGROUND: Intravenous belimumab plus standard of care (SoC) is approved in the USA and Europe for treatment of active, autoantibody-positive systemic lupus erythematosus (SLE). METHODS: This phase III, multicentre, randomised, double-blind, placebo-controlled study (BEL113750; NCT01345253) was conducted in 49 centres across China, Japan and South Korea (May 2011-September 2015). Patients with SLE were randomised 2:1 to intravenous belimumab 10 mg/kg or placebo, plus SoC, every 4 weeks until Week 48...
January 2, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29295824/inconsistency-between-danish-incidence-and-prevalence-data-about-psoriatic-arthritis-psa
#15
LETTER
Philipp Sewerin, Annika Hoyer, Matthias Schneider, Benedikt Ostendorf, Ralph Brinks
No abstract text is available yet for this article.
January 2, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29288210/switching-from-the-bio-originators-to-biosimilar-is-it-premature-to-recommend-this-procedure
#16
LETTER
Fabrizio Cantini, Maurizio Benucci
No abstract text is available yet for this article.
December 29, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29288209/efficacy-and-safety-of-tocilizumab-in-patients-with-refractory-takayasu-arteritis
#17
LETTER
Young Ho Lee, Gwan Gyu Song
No abstract text is available yet for this article.
December 29, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29288208/simultaneous-inhibition-of-%C3%AE-4-%C3%AE-7-integrin-and-tumour-necrosis-factor-%C3%AE-in-concomitant-spondyloarthritis-and-inflammatory-bowel-disease
#18
LETTER
Nicolas Richard, Elizabeth M Hazel, Nigil Haroon, Robert D Inman
No abstract text is available yet for this article.
December 29, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29275334/effect-of-rituximab-on-a-salivary-gland-ultrasound-score-in-primary-sj%C3%A3-gren-s-syndrome-results-of-the-tractiss-randomised-double-blind-multicentre-substudy
#19
Benjamin A Fisher, Colin C Everett, John Rout, John L O'Dwyer, Paul Emery, Costantino Pitzalis, Wan-Fai Ng, Andrew Carr, Colin T Pease, Elizabeth J Price, Nurhan Sutcliffe, Jimmy Makdissi, Anwar R Tappuni, Nagui S T Gendi, Frances C Hall, Sharon P Ruddock, Catherine Fernandez, Claire T Hulme, Kevin A Davies, Christopher John Edwards, Peter C Lanyon, Robert J Moots, Euthalia Roussou, Andrea Richards, Linda D Sharples, Michele Bombardieri, Simon J Bowman
OBJECTIVES: To compare the effects of rituximab versus placebo on salivary gland ultrasound (SGUS) in primary Sjögren's syndrome (PSS) in a multicentre, multiobserver phase III trial substudy. METHODS: Subjects consenting to SGUS were randomised to rituximab or placebo given at weeks 0, 2, 24 and 26, and scanned at baseline and weeks 16 and 48. Sonographers completed a 0-11 total ultrasound score (TUS) comprising domains of echogenicity, homogeneity, glandular definition, glands involved and hypoechoic foci size...
December 23, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29275333/adjuvite-a-double-blind-randomised-placebo-controlled-trial-of-adalimumab-in-early-onset-chronic-juvenile-idiopathic-arthritis-associated-anterior-uveitis
#20
Pierre Quartier, Amandine Baptiste, Véronique Despert, Emma Allain-Launay, Isabelle Koné-Paut, Alexandre Belot, Laurent Kodjikian, Dominique Monnet, Michel Weber, Caroline Elie, Bahram Bodaghi
OBJECTIVES: To assess the efficacy and safety of adalimumab on uveitis in patients with early onset, chronic, juvenile idiopathic arthritis (JIA)-associated or idiopathic anterior uveitis and an inadequate response to topical steroids and methotrexate (MTX). METHODS: Patients aged 4 years or more with ocular inflammation quantified by laser flare photometry (LFP) ≥30 photon units/ms were double-blindly randomised (1:1) to 2 groups, one treated with placebo and one with adalimumab subcutaneously at a dose of 24 mg/m2 in patients aged <13 years, 40 mg in the others, every other week...
December 23, 2017: Annals of the Rheumatic Diseases
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