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Annals of Neurology

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https://www.readbyqxmd.com/read/29461643/dysregulation-of-neurog2-plays-a-key-role-in-focal-cortical-dysplasia
#1
Simoni H Avansini, Fábio R Torres, André S Vieira, Danyella B Dogini, Fabio Rogerio, Ana C Coan, Marcia E Morita, Marilisa M Guerreiro, Clarissa L Yasuda, Rodrigo Secolin, Benilton S Carvalho, Murilo G Borges, Vanessa S Almeida, Patrícia A O R Araújo, Luciano Queiroz, Fernando Cendes, Iscia Lopes-Cendes
OBJECTIVE: Focal cortical dysplasias (FCDs) are an important cause of drug-resistant epilepsy. In this work we aimed to investigate whether abnormal gene regulation, mediated by microRNA, could be involved in FCD type II. METHODS: We used total RNA from the brain tissue of 16 patients with FCD type II and 28 controls. MicroRNA expression was initially assessed by microarray. Quantitative PCR (qPCR), in situ hybridization, luciferase reporter assays and deep sequencing for genes in the mTOR pathway were performed to validate and further explore our initial study...
February 20, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29460297/excess-amyloid-beta-can-be-degraded-in-healthy-humans
#2
LETTER
Arash Sadri
No abstract text is available yet for this article.
February 20, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29457845/reply-to-excess-amyloid-beta-can-be-degraded-in-healthy-humans
#3
LETTER
Brendan P Lucey, Terry J Hicks, Donald L Elbert, Vitaliy Ovod, Kwasi G Mawuenyega, John C Morris, Randall J Bateman
No abstract text is available yet for this article.
February 19, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29451323/-18f-av-1451-tau-pet-and-primary-progressive-aphasia
#4
Keith A Josephs, Peter R Martin, Hugo Botha, Christopher G Schwarz, Joseph R Duffy, Heather M Clark, Mary M Machulda, Jonathan Graff-Radford, Stephen D Weigand, Matthew L Senjem, Rene L Utianski, Daniel A Drubach, Bradley F Boeve, David T Jones, David S Knopman, Ronald C Petersen, Clifford R Jack, Val J Lowe, Jennifer L Whitwell
OBJECTIVES: To assess [ 18 F]AV-1451 tau-PET uptake patterns across the primary progressive aphasia (PPA) variants (logopenic, semantic and agrammatic), examine regional uptake patterns of [ 18 F]AV-1451 independent of clinical diagnosis, and compare the diagnostic utility of [ 18 F]AV-1451, [ 18 F]-fluorodeoxygluclose (FDG)-PET and MRI to differentiate the PPA variants. METHODS: We performed statistical parametric mapping of [ 18 F]AV-1451 across 40 PPA patients (logopenic-PPA=14, semantic-PPA=13 and agrammatic-PPA=13) compared to 80 cognitively normal, PiB-negative controls, age and gender matched 2:1...
February 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29451321/predicting-recovery-in-acute-post-stroke-aphasia
#5
Argye E Hillis, Yuan Ye Beh, Rajani Sebastian, Bonnie Breining, Donna C Tippett, Amy Wright, Sadhvi Saxena, Chris Rorden, Leonardo Bonilha, Alexandra Basilakos, Grigori Yourganov, Julius Fridriksson
OBJECTIVE: Many stroke patients show remarkable recovery of language after initial severe impairment, but it is difficult to predict which patients will show good recovery. We aimed to identify patient and lesion characteristics that together predict the best naming outcome in four studies. METHODS: We report two longitudinal studies that identified two variables at onset that were strongly associated with good recovery of naming (the most common residual deficit in aphasia) in the first six months after stroke: damage to left posterior superior temporal gyrus (pSTG) and/or superior longitudinal fasciculus/arcuate fasciculus (SLF/AF) and selective serotonin reuptake inhibitor (SSRI) use...
February 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29443416/diabetic-neuropathy-differs-between-type-1-and-type-2-diabetes-insights-from-magnetic-resonance-neurography
#6
Johann M E Jende, Jan B Groener, Dimitrios Oikonomou, Sabine Heiland, Stefan Kopf, Mirko Pham, Peter Nawroth, Martin Bendszus, Felix T Kurz
OBJECTIVE: To visualize and quantify differences of microstructural nerve damage in distal symmetric diabetic neuropathy (DPN) between type 1 diabetes (T1D) and type 2 diabetes (T2D), and to detect correlations between neuropathic symptoms and serological risk factors. METHODS: 3T magnetic resonance neurography of the sciatic nerve was performed in 120 patients (T1D n=35; T2D n=85) with either DPN (n=84) or no DPN (NDPN; n=36). Results were subsequently correlated with clinical, serological, and electrophysiological patient data...
February 14, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29420861/do-subjects-with-minimal-motor-features-have-prodromal-pd
#7
Yaping Chu, Aron S Buchman, C W Olanow, Jeffrey H Kordower
BACKGROUND: Understanding the pathological changes underlying mild motor features of the eldery and defining a patient population with prodromal Parkinson's disease (PD) are of great clinical importance. It remains unclear, however, how to accurately and specifically diagnose prodromal PD. We examined whether older adults with minimal parkinsonian motor features have nigrostriatal degeneration and α-synuclein pathology consistent with prodromal PD. METHODS: Brain sections were obtained from older adults with a clinical diagnosis of PD (N=21) and without a clinical diagnosis of PD (N=27) who underwent motor examination proximate to death...
February 8, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29420859/amygdala-stimulation-induced-apnea-is-attention-and-nasal-breathing-dependent
#8
William P Nobis, Stephen Schuele, Jessica W Templer, Guangyu Zhou, Gregory Lane, Joshua M Rosenow, Christina Zelano
OBJECTIVE: Evidence suggests disordered breathing is critically involved in Sudden unexplained death in epilepsy (SUDEP). To that end, evaluating structures that are activated by seizures and can activate brain regions that produce cardiorespiratory changes can further our understanding of the pathophysiology of SUDEP. Prior preclinical studies have shown that electrical stimulation of the human amygdala induces apnea, suggesting a role for the amygdala in controlling respiration. In this study, we aimed to both confirm these findings in a larger group of patients with intractable temporal lobe epilepsy (TLE) and also further explore the anatomical and cognitive properties of this effect...
February 8, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29420845/conscious-control-of-breathing-a-key-to-sudep-prevention
#9
Tobias Loddenkemper
No abstract text is available yet for this article.
February 8, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29420840/stereotactic-laser-amygdalohippocampotomy-for-mesial-temporal-lobe-epilepsy
#10
Robert E Gross, Matthew A Stern, Jon T Willie, Rebecca E Fasano, Amit M Saindane, Bruno P Soares, Nigel P Pedersen, Daniel L Drane
OBJECTIVE: To evaluate the outcomes one-year and longer following stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy in a large series of patients treated over a five-year period since introduction of this novel technique. METHODS: Surgical outcomes of a consecutive series of fifty-eight patients with mesial temporal lobe epilepsy who underwent the surgery at our institution with at least 12-months follow-up were retrospectively evaluated...
February 8, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29406582/high-complement-levels-in-astrocyte-derived-exosomes-of-alzheimer-s-disease
#11
Edward J Goetzl, Janice B Schwartz, Erin L Abner, Gregory A Jicha, Dimitrios Kapogiannis
OBJECTIVE: Astrocytes fulfill neuronal trophic roles normally, but are transformed in Alzheimer's disease (AD) into A1-type reactive astrocytes that may destroy neurons through unknown mechanisms. METHODS: To investigate astrocyte inflammatory mechanisms, astrocyte-derived exosomes (ADEs) were isolated immunochemically from plasmas of AD patients and matched controls for ELISA quantification of complement proteins. RESULTS: ADE levels of C1q, C4b, C3d, factor B, factor D, Bb, C3b and C5b-C9 terminal complement complex (TCC), but not mannose-binding lectin (MBL), normalized by the CD81 exosome marker were significantly higher for AD patients (n=28) than age- and gender-matched controls (all p<0...
February 6, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29406578/n-methyl-d-aspartate-receptor-antibody-production-from-germinal-center-reactions-therapeutic-implications
#12
Mateusz Makuch, Robert Wilson, Adam Al-Diwani, James Varley, Anne-Katrin Kienzler, Jennifer Taylor, Antonio Berretta, Darren Fowler, Belinda Lennox, M Isabel Leite, Patrick Waters, Sarosh R Irani
Introduction N-methyl-D-aspartate receptor (NMDAR)-antibody encephalitis is mediated by IgG-autoantibodies directed against the NR1-subunit of the NMDAR. Around 20% of patients have an underlying ovarian teratoma, and the condition responds to early immunotherapies and ovarian teratoma removal. However, despite clear therapeutic relevance, mechanisms of NR1-IgG production and the contribution of germinal center B cells to NR1-IgG levels are unknown. Methods Clinical data and longitudinal paired serum NR1-reactive IgM and IgG levels from ten patients with NMDAR-antibody encephalitis were determined...
February 6, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29405351/predicting-clinical-diagnosis-in-huntington-s-disease-an-imaging-polymarker
#13
Sarah L Mason, Richard E Daws, Eyal Soreq, Eileanoir B Johnson, Rachael I Scahill, Sarah J Tabrizi, Roger A Barker, Adam Hampshire
OBJECTIVE: Huntington's disease (HD) gene-carriers can be identified prior to clinical diagnosis; however, statistical models for predicting when overt motor symptoms will manifest are too imprecise to be useful at the level of the individual. Perfecting this prediction is integral to the search for disease modifying therapies. This study aimed to identify an imaging marker capable of reliably predicting real-life clinical diagnosis in HD. METHOD: A multivariate machine learning approach was applied to resting-state and structural MRI scans from 19 pre-manifest HD gene carriers (preHD, 8 of whom developed clinical disease in the 5 years post-scanning) and 21 healthy controls...
February 5, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29405350/orthostatic-heart-rate-changes-in-patients-with-autonomic-failure-caused-by-neurodegenerative-synucleinopathies
#14
Lucy Norcliffe-Kaufmann, Horacio Kaufmann, Jose-Alberto Palma, Cyndya A Shibao, Italo Biaggioni, Amanda C Peltier, Wolfgang Singer, Phillip A Low, David S Goldstein, Christopher H Gibbons, Roy Freeman, David Robertson
OBJECTIVE: Blunted tachycardia during hypotension is a characteristic feature of patients with autonomic failure, but the range has not been defined. This study reports the range of orthostatic heart rate (HR) changes in patients with autonomic failure caused by neurodegenerative synucleinopathies. METHODS: Patients evaluated at sites of the U.S. Autonomic Consortium (NCT01799915) underwent standardized autonomic function tests and full neurological evaluation. RESULTS: We identified 402 patients with orthostatic hypotension (OH) who had normal sinus rhythm...
February 5, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29394509/increase-of-hcn-current-in-the-aberrant-excitability-of-spinal-muscular-atrophy
#15
Hsing-Jung Lai, Chien-Lin Chen, Li-Kai Tsai
Objective The pathophysiology of spinal muscular atrophy (SMA) is still unclear. Methods The nerve excitability test in SMA patients and a mouse model of SMA was carried out to explore the pathophysiology of nodal and internodal currents, and quantitative PCR, Western blotting and whole-cell patch-clamp recording were used for the identified hypothesis. Results The nerve excitability test in SMA patients showed increased inward rectification in the current-threshold relationship and increased overshoot after hyperpolarizing threshold electrotonus, which indicates increased hyperpolarization-activated cyclic nucleotide-gated (HCN) current; these findings correlated with disease severity...
February 2, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29394508/activation-of-pial-and-dural-macrophages-and-dendritic-cells-by-csd-67-chrs
#16
Aaron J Schain, Agustin Melo-Carrillo, David Borsook, Jaime Grutzendler, Andrew M Strassman, Rami Burstein
OBJECTIVE: Cortical spreading depression (CSD) has long been implicated in migraine attacks with aura. The process by which CSD, a cortical event that occurs within the blood brain barrier (BBB), results in nociceptor activation outside the BBB is likely mediated by multiple molecules and cells. The objective of this study was to determine whether CSD activates immune cells inside the BBB (pia), outside the BBB (dura), or in both, and if so, when. METHODS: Investigating cellular events in the meninges shortly after CSD, we used in-vivo 2-photon imaging to identify changes in macrophages and dendritic cells (DC) that reside in the pia, arachnoid, and dura, and their anatomical relationship to TRPV1 axons...
February 2, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29394507/interpreting-alzheimer-s-disease-polygenic-scores
#17
Chin Hong Tan, Rahul S Desikan
No abstract text is available yet for this article.
February 2, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29394506/when-less-is-more-brain-comment-on-rivaroxaban-plasma-levels-in-acute-ischemic-stroke-and-intracerebral-hemorrhage
#18
Patrick D Lyden
No abstract text is available yet for this article.
February 2, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29394505/sleep-and-cognitive-decline-a-prospective-non-demented-elderly-cohort-study
#19
Seung Wan Suh, Ji Won Han, Ju Ri Lee, Seonjeong Byun, Soon Jai Kwon, Sang Hoon Oh, Kyoung Hwan Lee, Guehee Han, Jong Woo Hong, Kyung Phil Kwak, Bong-Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hui Kim, Seung-Ho Ryu, Seok Woo Moon, Joon Hyuk Park, Jiyeong Seo, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim
OBJECTIVE: To investigate sleep disturbances that induce cognitive changes over four years in non-demented elderlies. METHODS: Data were acquired from a nationwide, population-based, prospective cohort of Korean elderlies (2,238 normal cognition [NC] and 655 mild cognitive impairment [MCI]). At baseline and 4-year follow up assessments, sleep-related parameters (mid-sleep time, sleep duration, latency, subjective quality, efficiency and daytime dysfunction) and cognitive status were measured using Pittsburgh Sleep Quality Index and Consortium to Establish a Registry for Alzheimer's Disease Assessment, respectively...
February 2, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29394504/rivaroxaban-plasma-levels-in-acute-ischemic-stroke-and-intracerebral-hemorrhage
#20
David J Seiffge, Georg Kägi, Patrik Michel, Urs Fischer, Yannick Béjot, Susanne Wegener, Marialuisa Zedde, Guillaume Turc, Charlotte Cordonnier, Peter S Sandor, Gilles Rodier, Andrea Zini, Manuel Cappellari, Sabine Schädelin, Alexandros A Polymeris, David Werring, Sebastian Thilemann, Ilaria Maestrini, Eivind Berge, Christopher Traenka, Jochen Vehoff, Gian Marco De Marchis, Monika Kapauer, Nils Peters, Gaia Sirimarco, Leo H Bonati, Marcel Arnold, Philippe A Lyrer, Emmanuel De Maistre, Andreas Luft, Dimtrios A Tsakiris, Stefan T Engelter
OBJECTIVE: Information about Rivaroxaban plasma levels (RivLev) may guide treatment decisions in patients with acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH) taking rivaroxaban. METHODS: In a multicenter registry-based study (Novel-Oral-Anticoagulants-In-Stroke-Patients collaboration;NOACISP;ClinicalTrials.gov:NCT02353585) of patients with stroke while taking rivaroxaban, we compared RivLev in patients with AIS and ICH. We determined how many AIS-patients had RivLev≤100ng/ml, indicating possible eligibility for thrombolysis and how many ICH-patients had RivLev≥75ng/ml, possibly eligible for the use of specific reversal agents...
February 2, 2018: Annals of Neurology
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