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Annals of Neurology

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https://www.readbyqxmd.com/read/28544007/fletcher-h-mcdowell-md-1923-2017
#1
EDITORIAL
Jesse M Cedarbaum, Mindy Aisen, Bruce T Volpe
No abstract text is available yet for this article.
May 22, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28543735/the-repetition-of-behavioral-assessments-in-diagnosis-of-disorders-of-consciousness
#2
Sarah Wannez, Lizette Heine, Marie Thonnard, Olivia Gosseries, Steven Laureys
OBJECTIVE: To determine whether repeated examinations using the Coma Recovery Scale-Revised have an impact on diagnostic accuracy of patients with disorders of consciousness and to provide guidelines regarding the number of assessments required for obtaining a reliable diagnosis. METHODS: 123 adult patients with chronic disorders of consciousness were referred to our tertiary center. They were assessed at least 6 times with the Coma Recovery Scale-Revised within a 10-day period...
May 22, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28543731/neuroimaging-biomarkers-and-impaired-olfaction-in-cognitively-normal-individuals
#3
Maria Vassilaki, Teresa J Christianson, Michelle M Mielke, Yonas E Geda, Walter K Kremers, Mary M Machulda, David S Knopman, Ronald C Petersen, Val J Lowe, Clifford R Jack, Rosebud O Roberts
OBJECTIVE: There is a need for inexpensive non-invasive tests to identify older healthy persons at risk for Alzheimer's disease (AD) for enrollment in AD prevention trials. Our objective was to examine whether abnormalities in neuroimaging measures of amyloid and neurodegeneration are correlated with odor identification (OI) in the population-based Mayo Clinic Study of Aging (MCSA). METHODS: Cognitively normal (CN) participants had olfactory function assessed using the Brief Smell Identification Test (B-SIT), underwent magnetic resonance imaging (MRI; n=829) to assess a composite Alzheimer's disease (AD) signature cortical thickness and hippocampal volume (HVa), and, (11) C-Pittsburgh compound B ((11) C-PiB; n=306) and (18) fluorodeoxyglucose ((18) F-FDG; n=305) positron emission tomography (PET) scanning to assess amyloid accumulation and brain hypometabolism, respectively...
May 22, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28543679/the-missing-the-short-and-the-long-l-dopa-responses-and-dopamine-actions
#4
Roger L Albin, Daniel K Leventhal
We attempt to correlate the clinical pharmacology of dopamine replacement therapy (DRT) in Parkinson Disease with known features of striatal dopamine actions. Despite its obvious impact, DRT does not normalize motor function, likely due to disrupted phasic dopaminergic signaling. The DRT Short Duration Response is likely a permissive-paracrine effect, possibly resulting from dopaminergic support of corticostriate synaptic plasticity. The DRT Long Duration Response may result from mimicry of tonic dopamine signaling regulation of movement vigor...
May 22, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28512753/serum-neurofilament-light-a-biomarker-of-neuronal-damage-in-multiple-sclerosis
#5
Giulio Disanto, Christian Barro, Pascal Benkert, Yvonne Naegelin, Sabine Schädelin, Antonella Giardiello, Chiara Zecca, Kaj Blennow, Henrik Zetterberg, David Leppert, Ludwig Kappos, Claudio Gobbi, Jens Kuhle
OBJECTIVE: Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the CSF and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. We explored the value of an ultrasensitive single-molecule array (Simoa) serum NfL (sNfL) assay in MS. METHODS: sNfL levels were measured in healthy controls (HC, n=254) and two independent MS cohorts: (1) cross-sectional with paired serum and CSF samples (n=142); (2) longitudinal with repeated serum sampling (n=246, median (IQR) follow-up 3...
May 16, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28486789/ct-perfusion-to-predict-response-to-recanalization-in-ischemic-stroke
#6
Maarten G Lansberg, Soren Christensen, Stephanie Kemp, Michael Mlynash, Nishant Mishra, Christian Federau, Jenny P Tsai, Sun Kim, Raul G Nogueria, Tudor Jovin, Thomas G Devlin, Naveed Akhtar, Dileep R Yavagal, Diogo Haussen, Seena Dehkharghani, Roland Bammer, Matus Straka, Greg Zaharchuk, Michael P Marks, Gregory W Albers
OBJECTIVE: To assess the utility of CT perfusion for selection of patients for endovascular therapy up to 18 hours after symptom onset. METHODS: We conducted a multicenter cohort study of consecutive acute stroke patients scheduled to undergo endovascular therapy within 90 min after a baseline CTP. Patients were classified as 'target mismatch' if they had a small ischemic core and a large penumbra on their baseline CT perfusion. Reperfusion was defined as >50% reduction in critical hypoperfusion between the baseline CT perfusion and the 36-hour follow-up MRI...
May 9, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28486773/nonpublication-of-trial-results-for-new-neurological-drugs-a-systematic-review
#7
REVIEW
Amanda K Hakala, Dean Fergusson, Jonathan Kimmelman
OBJECTIVE: To evaluate nonpublication rates among trials of new successful and unsuccessful neurological drugs. METHODS: 'Licensed' drugs consisted of all novel agents receiving FDA licensure 2005 to 2012 inclusive in seven neurological disorders. 'Stalled' drugs included all experimental agents tested in the same domains that had at least one completed phase III trial in the same timeframe but failed to receive FDA approval. Trials of these drugs were included in our sample if their primary outcome collection occurred before October 1, 2010...
May 9, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28486769/chemotherapy-induced-peripheral-neuropathy-a-current-review
#8
REVIEW
Nathan P Staff, Anna Grisold, Wolfgang Grisold, Anthony J Windebank
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect experienced by patients receiving treatment for cancer. Approximately 30-40% of patients treated with neurotoxic chemotherapy will develop CIPN and there is considerable variability in its severity between patients. It is often sensory-predominant with pain and can lead to long-term morbidity in survivors. The prevalence and burden of CIPN late effects will likely increase as cancer survival rates continue to improve. In this review, we discuss the approach to peripheral neuropathy in patients with cancer and address the clinical phenotypes and pathomechanisms of specific neurotoxic chemotherapeutic agents...
May 9, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28480639/pyrimethamine-significantly-lowers-csf-sod1-in-als-patients-with-sod1-mutations
#9
Dale J Lange, Mona Shahbazi, Vincenzo Silani, Albert C Ludolph, Jochen H Weishaupt, Senda Ajroud-Driss, Kara G Fields, Rahul Remanan, Stanley H Appel, Claudia Morelli, Alberto Doretti, Luca Maderna, Stefano Messina, Ulrike Weiland, Stefan L Marklund, Peter M Andersen
BACKGROUND: Cu/Zn superoxide dismutase (SOD1) reduction prolongs survival in SOD1-transgenic animal models. Pyrimethamine produces dose dependent SOD1 reduction in cell culture systems. A previous phase-1 trial showed pyrimethamine lowers SOD1 levels in leucocytes in patients with SOD1 mutations. This study investigated whether pyrimethamine lowered SOD1 levels in the cerebrospinal fluid (CSF) in patients carrying SOD1 mutations linked to ALS (fALS/SOD1). METHODS AND STUDY DESIGN: Multicenter (5 sites), open-label, 9-month duration, dose-ranging, to determine safety and efficacy of pyrimethamine to lower SOD1 levels in the CSF of FALS/SOD1...
May 8, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28472861/pure-autonomic-failure-vs-manifest-cns-synucleinopathy-relevance-of-stridor-and-autonomic-biomarkers
#10
LETTER
Horacio Kaufmann, Lucy Norcliffe-Kaufmann, Jose-Alberto Palma
No abstract text is available yet for this article.
May 4, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28472851/letter-on-natural-history-of-pure-autonomic-failure-a-united-states-prospective-cohort
#11
LETTER
Michael H Silber, Bradley F Boeve, Erik K St Louis
No abstract text is available yet for this article.
May 4, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28470695/sublethal-oligodendrocyte-injury-a-reversible-condition-in-multiple-sclerosis
#12
Qiao-Ling Cui, Damla Khan, Malena Rone, Vijayaraghava Rao, Radia Marie Johnson, Yun Hsuan Lin, Philippe-Antoine Bilodeau, Jeffery A Hall, Moses Rodriguez, Timothy E Kennedy, Samuel K Ludwin, Jack P Antel
OBJECTIVE: Degeneration of oligodendroglial distal processes has been identified as an early event in MS lesion development. Our objective was to further define the development of the "dying-back" oligodendrocyte lesion in situ and to model the development and potential reversibility of such responses using dissociated cultures of adult human brain-derived oligodendrocytes. Methods In situ analyses were performed on glutaraldehyde-fixed thin sections of clinically acute and pathologically active cases of MS...
May 3, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28470693/stn-dbs-is-neuroprotective-in-the-a53t-%C3%AE-synuclein-parkinson-s-disease-rat-model
#13
Thomas Musacchio, Maike Rebenstorff, Felix Fluri, Jonathan M Brotchie, Jens Volkmann, James B Koprich, Chi Wang Ip
OBJECTIVE: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective symptomatic therapy for motor deficits in Parkinson's disease (PD). An additional, disease-modifying effect has been suspected from studies in toxin-based PD animal models, but these models do not reflect the molecular pathology and progressive nature of PD, that would be required to evaluate a disease-modifying action. Defining a disease-modifying effect, could radically change the way in which DBS is used in PD...
May 3, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28470692/viral-tracing-of-presynaptic-inputs-to-newly-born-dentate-granule-cells-in-a-rodent-model-of-mesial-temporal-lobe-epilepsy
#14
Scott C Baraban
No abstract text is available yet for this article.
May 3, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28470680/rabies-tracing-of-birthdated-dentate-granule-cells-in-rat-temporal-lobe-epilepsy
#15
Xi Du, Helen Zhang, Jack M Parent
OBJECTIVE: To understand how monosynaptic inputs onto adult-born dentate granule cells (DGCs) are altered in experimental mesial temporal lobe epilepsy (mTLE) and whether their integration differs from early-born DGCs that are mature at the time of epileptogenesis. METHODS: A dual-virus tracing strategy combining retroviral birthdating with rabies virus-mediated putative retrograde trans-synaptic tracing was used to identify and compare presynaptic inputs onto adult- and early-born DGCs in the rat pilocarpine model of mTLE...
May 3, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28470675/early-prediction-of-coma-recovery-after-cardiac-arrest-with-blinded-pupillometry
#16
Daria Solari, Andrea O Rossetti, Laurent Carteron, John-Paul Miroz, Jan Novy, Philippe Eckert, Mauro Oddo
Objectives Prognostication studies on comatose cardiac arrest (CA) patients are limited by lack of blinding, potentially causing overestimation of outcome predictors and self-fulfilling prophecy. Using a blinded approach, we analysed the value of quantitative automated pupillometry to predict neurological recovery after CA. Methods We examined a prospective cohort of 103 comatose adult patients who were unconscious 48 hours after CA and underwent repeated measurements of quantitative pupillary light reflex (PLR) using the Neurolight-Algiscan® device...
May 3, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28445916/brain-regions-essential-for-word-comprehension-drawing-inferences-from-patients
#17
Argye E Hillis, Christopher Rorden, Julius Fridriksson
Lesion-deficit association studies are important as they can reveal brain regions essential for specific functions, but sometimes appear to yield conflicting results. We aimed to show how pitfalls of lesions studies can be avoided, and converging results obtained, illustrating from studies of the role of posterior superior temporal gyrus in auditory word comprehension. We review published lesion studies on auditory comprehension and present new data from both acute and chronic stroke that address weaknesses in some previous studies...
April 26, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28440033/rigor-reproducibility-and-in-vitro-csf-assays-the-devil-in-the-details
#18
LETTER
Olivia A Moody, Sahil Talwar, Meagan A Jenkins, Amanda A Freeman, Lynn Marie Trotti, Paul S García, Donald Bliwise, Joseph W Lynch, Brad Cherson, Eric M Hernandez, Neil Feldman, Prabhjyot Saini, David B Rye, Andrew Jenkins
No abstract text is available yet for this article.
April 25, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28439988/confirmation-of-absence-of-gaba-a-receptor-potentiation-in-idiopathic-hypersomnia
#19
LETTER
Yves Dauvilliers, Pierre Charnet
No abstract text is available yet for this article.
April 25, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28439961/involvement-of-the-cerebellum-in-parkinson-s-disease-and-dementia-with-lewy-bodies
#20
K Seidel, M Bouzrou, N Heidemann, R Krüger, L Schöls, Wfa den Dunnen, H-W Korf, U Rüb
Patient brains with Parkinson's disease or Dementia with Lewy bodies show aggregation of alpha-synuclein in pre-cerebellar brainstem structures. Furthermore, patients exhibit resting tremor, unstable gait and impaired balance which may be associated with cerebellar dysfunction. Therefore, we screened the cerebella of 12 patients with alpha-synucleinopathies for neuropathological changes. Cerebellar nuclei and neighboring white matter displayed numerous aggregates, while lobules were mildly affected. Cerebellar aggregation pathology may suggest a prion-like spread originating from affected precerebellar structures and the high homogeneity between patients with Dementia with Lewy bodies and Parkinson's disease shows that both diseases likely belong to the same neuropathological spectrum...
April 25, 2017: Annals of Neurology
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