journal
MENU ▼
Read by QxMD icon Read
search

Annals of Medicine

journal
https://www.readbyqxmd.com/read/28010116/chrono-integrates-behavioral-stress-and-epigenetic-control-of-metabolism
#1
Fumiyuki Hatanaka, Toru Takumi
Circadian rhythms are a critical part of the body's homeostatic mechanisms. These rhythms repeat with a cycle-length of approximately 24 h and are generated by a transcriptional-translational feedback loop. These rhythms are critical for proper behavioral, physiological, and molecular functions. CHRONO, a novel circadian clock gene, forms a complex with other clock proteins and modulates the circadian machinery. CHRONO also interacts with histone deacetylase (HDAC) to modulate the epigenetic status of the transcriptional regulation...
January 19, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28084122/plasma-endothelin-1-levels-in-patients-with-resistant-hypertension-effects-of-renal-sympathetic-denervation
#2
Luigi Petramala, Federica Olmati, Massimo Mancone, Antonio Concistré, Matteo Galassi, Cristiano Marinelli, Gianfranco Tonnarini, Piernatale Lucia, Umberto Costi, Gino Iannucci, Gennaro Sardella, Claudio Letizia
INTRODUCTION: Resistant arterial hypertension (RHT) is defined as poor controlled blood pressure (BP) despite optimal doses of 3 or more antihypertensive agents, including a diuretic. In the development of RHT, hyperactivity of sympathetic (SNS) and renin-angiotensin-aldosterone (SRAA) systems are involved, and SNS is a potent stimulator of vasoactive endothelin-1 (ET1) peptide. Renal sympathetic denervation (RSD) through disrupting renal afferent and efferent nerves attenuates SNS activity...
January 13, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28084107/the-risk-of-gastrointestinal-bleeding-in-patients-receiving-dabigatran-etexilate-a-systematic-review-and-meta-analysis-of-the-literature
#3
Matteo Nicola Dario Di Minno, Pasquale Ambrosino, Alessandro Di Minno, Elena Tremoli, Giovanni Di Minno
BACKGROUND: Evidence on the risk of gastrointestinal (GI) bleeding associated with dabigatran etexilate (DE) is contrasting. We performed a meta-analysis of literature to address this issue. METHODS AND RESULTS: Studies on GI bleeding risk in patients receiving DE or vitamin-K antagonists (VKA) were systematically searched. Twenty-three studies (26 datasets) showed no difference in the GI bleeding risk between the 250,871 patients treated with DE and the 460,386 receiving VKA (OR: 1...
January 13, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28042730/sex-age-and-time-to-cardioversion-risk-factors-for-cardioversion-of-acute-atrial-fibrillation-from-the-fincv-study
#4
Aissa Bah, Ilpo Nuotio, Toni Grönberg, Antti Ylitalo, K E Juhani Airaksinen, Juha E K Hartikainen
BACKGROUND: Female sex, old age, and time to cardioversion increase the risk of thromboembolic complications (TEC) after cardioversion of atrial fibrillation (AF) < 48 h. The interaction of these variables is not known. We investigated the interaction of sex, age, and time to electrical cardioversion (ECV) on TEC in anticoagulant-naive patients with acute AF. METHODS AND RESULTS: The primary outcome was a TEC within 30 days following ECV. Patients were divided into three age groups and time to cardioversion into <12 h and ≥12 h in 4715 ECVs...
December 31, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/28042729/critical-laboratory-values-in-hemostasis-towards-consensus
#5
Giuseppe Lippi, Dorothy Adcock, Ana-Maria Simundic, Armando Tripodi, Emmanuel J Favaloro
The term 'critical values' can be defined to entail laboratory test results which significantly lie outside the normal (reference) range and necessitate immediate reporting to safeguard patient health, as well as those displaying a highly and clinically significant variation compared to previous data. The identification and effective communication of "highly pathological" values has engaged the minds of many clinicians, healthcare and laboratory professionals for decades, since these activities are vital to good laboratory practice...
December 31, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/28042719/insulins-nph-glargine-and-detemir-and-risk-of-severe-hypoglycaemia-among-working-age-adults
#6
Arto Y Strandberg, Houssem Khanfir, Sari Mäkimattila, Tero Saukkonen, Timo E Strandberg, Fabian Hoti
INTRODUCTION: The longer acting basal insulin analogues glargine and detemir have shown a lower incidence of hypoglycaemia compared to insulin NPH in clinical studies. We evaluated the real-life risk of severe hypoglycaemia among new users of insulins in the working-age population in Finland. METHODS: All persons aged 18-65 years with diabetes mellitus who were newly prescribed with insulins NPH, glargine, or detemir during 2006-2009, were identified from national registers...
December 31, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27499431/serum-uric-acid-change-and-modification-of-blood-pressure-and-fasting-plasma-glucose-in-an-overall-healthy-population-sample-data-from-the-brisighella-heart-study
#7
Arrigo F G Cicero, Martina Rosticci, Marilisa Bove, Federica Fogacci, Marina Giovannini, Riccardo Urso, Sergio D'Addato, Claudio Borghi
BACKGROUND: Serum uric acid (SUA) is an emerging risk factor for incident hypertension and type 2 diabetes. It is less clear if changes in SUA are associated to different incidence in these main cardiovascular risk factors. METHODS: From the cohort of the Brisighella Heart Study, we selected non-diabetic subjects that in 2008 were untreated with SUA-lowering drugs nor antihypertensive ones. Then we divided the subjects in four main groups: the ones that maintained their SUA level unchanged during the next 4 years, the ones that increased it >1 mg/dL without treatment, the ones that reduced it >1 mg/dL without drug treatment and the ones that reduced it >1 mg/dL with the continuous use of allopurinol...
December 16, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27786563/non-invasive-pre-implantation-aneuploidy-screening-and-diagnosis-of-beta-thalassemia-ivsii654-mutation-using-spent-embryo-culture-medium
#8
WeiQiang Liu, JianQiao Liu, HongZi Du, JiaWei Ling, XiaoFang Sun, DunJin Chen
BACKGROUND: Cell-free nuclear DNA has been isolated from spent embryo culture medium. Whether this small amount of DNA can be amplified at the whole genome level and the concordance rate of karyotypes and specific alleles between biopsied cells and media has not been evaluated. METHODS: Seven couples were recruited, 88 donated embryos and their corresponding media were collected for whole genome amplification (WGA). The efficiency of WGA, the concordance of chromosome status, and the HBB gene IVSII654 allele between biopsied cells and media were investigated...
December 14, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27936959/significance-of-perioperative-goal-directed-hemodynamic-approach-in-preventing-postoperative-complications-in-patients-after-cardiac-surgery-a-meta-analysis-and-systematic-review
#9
Peng Li, Li-Ping Qu, Dong Qi, Bo Shen, Yi-Mei Wang, Jia-Rui Xu, Wu-Hua Jiang, Hao Zhang, Xiao-Qiang Ding, Jie Teng
PURPOSE: Goal-directed hemodynamic therapy (GDT) is used to prevent hypoperfusion resulting from surgery. The objective of this study was to analyze the efficacy and importance of perioperative GDT. METHODS: PUBMED, MEDLINE, CENTRAL, and Google Scholar databases were searched until June 17, 2016 using the search terms: cardiac output, cardiac surgical procedures, hemodynamics, goal-directed therapy, and intraoperative. Randomized-controlled trials with pre-emptive hemodynamic intervention for cardiac surgical population versus standard hemodynamic therapy were included...
December 12, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27936950/cardiometabolic-diseases-of-civilization-history-and-maturation-of-an-evolving-global-threat-an-update-and-call-to-action
#10
Richard Kones, Umme Rumana
Despite striking extensions of lifespan, leading causes of death in most countries now constitute chronic, degenerative diseases which outpace the capacity of health systems. Cardiovascular disease is the most common cause of death in both developed and undeveloped countries. In America, nearly half of the adult population has at least one chronic disease, and polypharmacy is commonplace. Prevalence of ideal cardiovascular health has not meaningfully improved over the past two decades. The fall in cardiovascular deaths in Western countries, half due to a fall in risk factors and half to improved treatments, have plateaued, and this reversal is due to the dual epidemics of obesity and diabetes type 2...
December 12, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27690642/regulatory-t-cd4%C3%A2-%C3%A2-cd25-lymphocytes-increase-in-symptomatic-carotid-artery-stenosis
#11
Flavia Del Porto, Noemi Cifani, Maria Proietta, Sara Perrotta, Raffaele Dito, Cira di Gioia, Raffaella Carletti, Luigi Rizzo, Gianluigi Orgera, Michele Rossi, Livia Ferri, Luigi Tritapepe, Maurizio Taurino
BACKGROUND: Atherosclerosis is a multifactorial disease characterized by an immune-inflammatory remodeling of the arterial wall. Treg and Th17 subpopulations are detectable inside atherosclerotic plaque; however, their behavior in symptomatic carotid artery stenosis (CAS) is not fully elucidated. The aim of this study was to evaluate Th17 and Treg subsets and their ratio in patients affected by symptomatic and asymptomatic CAS. METHODS: 14 patients with symptomatic CAS (CAS-S group), 41 patients with asymptomatic CAS (CAS-A group), 32 subjects with traditional cardiovascular risk factors (RF group), and 10 healthy subjects (HS group) were enrolled...
December 8, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27791388/a-narrative-review-about-blood-laboratory-testing-for-early-prediction-of-preeclampsia-chasing-the-finish-line-or-at-the-starting-blocks
#12
Martina Montagnana, Elisa Danese, Giuseppe Lippi, Cristiano Fava
Preeclampsia (PE) affects 2-8% of pregnancies worldwide, thus representing an important cause of maternal and neonatal morbidity, up to death. Many studies have been designed to identify putative biomarkers for accurate and timely diagnosing PE, but only some of them were focused on specific and sensitive biomarkers for early prediction of this life-threatening condition. In particular, some prospective studies aimed to investigate the predictive role of circulating biomarkers before 20 weeks of gestation in the general pregnant population yielded conflicting results...
October 28, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27764976/clinical-usefulness-of-the-oxford-classification-in-determining-immunosuppressive-treatment-in-iga-nephropathy
#13
Chang-Yun Yoon, Tae Ik Chang, Ea Wha Kang, Beom Jin Lim, Jeong Hae Kie, Youn Kyung Kee, Hyoungnae Kim, Seohyun Park, Hae-Ryong Yun, Su-Young Jung, Jong Hyun Jhee, Young Eun Kwon, Hyung Jung Oh, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Hyeon Joo Jeong, Seung Hyeok Han
BACKGROUND: The Oxford classification has been widely used in IgA nephropathy. However, its clinical usefulness of determining immunosuppression is unknown. AIM: Whether the Oxford classification could predict the development of proteinuria ≥1 g/g Cr and worsening kidney function, as well as the clinical efficacy of corticosteroid treatment according to each histologic variable of the Oxford-MEST. METHODS: We included 377 patients with early-stage IgA nephropathy...
November 29, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27685190/pathogenesis-of-ligaments-ossification-in-spondyloarthritis-insights-and-doubts
#14
Anna Neve, Nicola Maruotti, Addolorata Corrado, Francesco Paolo Cantatore
Despite intensive research in spondyloarthritis pathogenesis, some important questions still remain unanswered, particularly concerning enthesis new bone formation. Several evidences suggest that it prevalently occurs by endochondral ossification, however it remains to identify factors that can induce and influence its initiation and progression. Recent progress, achieved in animal models and in vitro and genetic association studies, has led us to hypothesize that several systemic factors (adipokines and gut hormones) and local factors (BMP and Wnt signaling) as well as angiogenesis and mechanical stress are involved...
November 12, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27665938/center-based-patient-care-enhances-survival-of-elderly-patients-suffering-from-peripheral-arterial-disease
#15
Clemens Höbaus, Carsten Thilo Herz, Florian Obendorf, Marie-Therese Howanietz, Thomas Wrba, Renate Koppensteiner, Gerit-Holger Schernthaner
OBJECTIVES: Recent advances in catheter-based intervention in patients with symptomatic peripheral arterial disease (PAD) have halved mortality. Mortality of PAD patients still remains high compared to other clinical forms of atherosclerosis. Intensified patient care might increase adherence to medical management and benefit the survival of PAD patients. METHODS: Two patient cohorts were compared in a longitudinal prospective follow-up study. 370 PAD patients were included in the intensified center-based vascular medicine group (VMC group) and 332 PAD patients were treated by their usual primary care physician (PCP group)...
November 12, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27813419/anti-interleukin-2-receptor-antibodies-for-the-prevention-of-rejection-in-liver-transplant-recipients-a-systematic-review-and-meta-analysis
#16
Yi Zhang, Weidong Jin, Xun Cai
BACKGROUND: Antibody induction therapy aims to prevent acute cellular rejection by reducing T-cell proliferation and activation. We evaluated the efficacy and side effects of two anti-interleukin-2 receptor antibodies (IL2RA), basiliximab and daclizumab, for prevention of liver transplant rejection in adult patients. METHODS: Randomized controlled trials on basiliximab or daclizumab were identified by searching multiple databases and reference lists published up to July, 2015...
November 4, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27786555/seasonality-of-stroke-in-finland
#17
Jussi Sipilä, Jori O Ruuskanen, Tommi Kauko, Päivi Rautava, Ville Kytö
INTRODUCTION: The burden of stroke is increasing globally. Reports on seasonal variations in stroke occurrence are conflicting and long-term data is absent. METHODS: A retrospective cohort study using discharge registry data of all acute stroke admissions in Finland in 2004-2014 for patients ≥18 years age. 97018 admissions for ischemic stroke (IS) were included, 18252 admissions for intracerebral haemorrhage (ICH) and 11271 admissions for subarachnoid haemorrhage (SAH)...
October 27, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27786552/use-of-antidementia-drugs-and-risk-of-pneumonia-in-older-persons-with-alzheimer-s-disease
#18
Pasi Lampela, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Piia Lavikainen, Sirpa Hartikainen, Heidi Taipale
INTRODUCTION: Persons with Alzheimer's disease are at an increased risk of pneumonia, but the comparative risks during specific antidementia treatments are not known. We compared the risk of pneumonia in use of donepezil, rivastigmine (oral, transdermal), galantamine and memantine. PATIENTS AND METHODS: We used data from a nationwide cohort of community-dwelling individuals diagnosed with Alzheimer's disease during 2005-2011 in Finland, who initiated monotherapy with acetylcholinesterase inhibitor or memantine (n = 65481)...
October 27, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27764967/cardiovascular-fitness-in-young-males-and-risk-of-unprovoked-venous-thromboembolism-in-adulthood
#19
Bengt Zöller, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
BACKGROUND: Whether high cardiovascular fitness is associated with reduced risk of venous thromboembolism (VTE) is unknown. The present study aims to determine whether high cardiovascular fitness reduces the risk of VTE. METHODS: A Swedish cohort of male conscripts (n = 773,925) born in 1954-1970 with no history of previous VTE were followed from enlistment (1972-1990) until 2010. Data on cardiovascular fitness using a cycle ergonometric test (maximal aerobic workload in Watt [Wmax]) at conscription were linked with national hospital register data and the Multi-Generation Register...
March 2017: Annals of Medicine
https://www.readbyqxmd.com/read/27763780/systemic-effects-of-controlled-exposure-to-diesel-exhaust-a-meta-analysis-from-randomized-controlled-trials
#20
Jefferson Luis Vieira, Francisco Yuri Macedo, Alexandre Miguel Benjo, Guilherme V Guimarães, Johanna Paola Contreras, Edimar A Bocchi
INTRODUCTION: Ambient air pollution is associated with adverse cardiovascular events. This meta-analysis aimed to investigate the short-term association between air pollution and cardiovascular effects on healthy volunteers. METHODS: We searched databases to identify randomized trials with controlled human exposures to either of two models for studying ambient particulate matter: diesel-exhaust or concentrated ambient particles. Estimates of size effect were performed using standardized mean difference (SMD)...
March 2017: Annals of Medicine
journal
journal
20033
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"