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Annals of Medicine

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https://www.readbyqxmd.com/read/29027470/next-generation-sequencing-applications-for-cardiovascular-disease
#1
Samira Kalayinia, Hamidreza Goodarzynejad, Majid Maleki, Nejat Mahdieh
The Human Genome Project (HGP), as the primary sequencing of the human genome, lasted more than one decade to be completed using the traditional Sanger's method. At present, next-generation sequencing (NGS) technology could provide the genome sequence data in hours. NGS has also decreased the expense of sequencing; therefore, nowadays it is possible to carry out both whole-genome (WGS) and whole-exome sequencing (WES) for the variations detection in patients with rare genetic diseases as well as complex disorders such as common cardiovascular diseases (CVDs)...
October 13, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28972811/mechanical-dispersion-is-associated-with-poor-outcome-in-heart-failure-with-a-severely-depressed-left-ventricular-function-and-bundle-branch-blocks
#2
Ivan Stankovic, Aleksandra Janicijevic, Aleksandra Dimic, Milica Stefanovic, Radosav Vidakovic, Biljana Putnikovic, Aleksandar N Neskovic
OBJECTIVES: Bundle branch blocks (BBB)-related mechanical dyssynchrony and dispersion may improve patient selection for device therapy, but their effect on the natural history of this patient population is unknown. METHODS: A total of 155 patients with LVEF ≤ 35% and BBB, not treated with device therapy, were included. Mechanical dyssynchrony was defined as the presence of either septal flash or apical rocking. Contraction duration was assessed as time interval from the electrocardiographic R-(Q-)wave to peak longitudinal strain in each of 17 left ventricular segments...
October 13, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28985689/effect-of-age-period-and-birth-cohort-on-the-frequency-of-glucose-6-phosphate-dehydrogenase-deficiency-in-sardinian-adults
#3
Giovanni M Pes, Alessandra Errigo, Angela Bitti, Maria Pina Dore
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited disorder common in Sardinia. In this study the frequency variation of G6PD-deficiency across age groups and birth cohorts were investigated using Age-Period-Cohort analysis. METHODS: Data were collected from the clinical records of 11,252 patients (6,975 women, age range 17-94 years) who underwent endoscopy between 2000 and 2016 at a teaching hospital (University of Sassari), Italy. G6PD status was assessed by enzymatic assay based on G6PD/6GPD ratio...
October 6, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28972808/joint-associations-of-sauna-bathing-and-cardiorespiratory-fitness-on-cardiovascular-and-all-cause-mortality-risk-a-long-term-prospective-cohort-study
#4
Setor K Kunutsor, Hassan Khan, Tanjaniina Laukkanen, Jari A Laukkanen
PURPOSE: We aimed to evaluate the joint impact of cardiorespiratory fitness (CRF) and frequency of sauna bathing (FSB) on the risk of cardiovascular and all-cause mortality. DESIGN: CRF measured by respiratory gas analyses and sauna exposure were assessed at baseline in a prospective study of 2,277 men. CRF was categorized as low and high (median cutoffs) and FSB as low and high (≤ 2 and 3-7 sessions/week respectively). RESULTS: During a median follow-up of 26...
October 3, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28972798/the-role-of-levothyroxine-in-obstetric-practice
#5
Inés Velasco, Peter Taylor
Thyroid hormones play a pivotal role in somatic growth, metabolic regulation and neurodevelopment. There is growing evidence regarding adverse obstetric and perinatal consequences of maternal thyroid hypofunction during early stages of pregnancy. These include: early pregnancy loss, preterm delivery and lower intelligence quotient (IQ) in children. Different clinical guidelines have been published by scientific societies for the management of thyroid diseases during pregnancy and levothyroxine (LT4) has become a therapeutic agent increasingly prescribed by obstetricians...
October 3, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28927303/case-fatality-of-acute-coronary-events-is-improving-even-among-elderly-patients-the-finami-study-1995-2012
#6
Heli Koukkunen, Aki S Havulinna, Seppo Lehto, Matti Ketonen, Juha Mustonen, Juhani K Airaksinen, Olavi Ukkola, Y Antero Kesäniemi, Veikko Salomaa
AIM: To examine trends in incidence and 28-day case fatality of myocardial infarction (MI) in persons aged 75-99 years in four areas of Finland. METHODS AND RESULTS: The Finnish Acute Myocardial Infarction (FINAMI) register is a population-based MI register study, which during 1995-2012 recorded 30561 suspected acute coronary syndromes in persons aged ≥75 years. Of them, 16229 fulfilled the American Heart Association criteria for a definite, probable or possible MI or coronary death...
October 3, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28929822/genetic-and-ethnic-modulation-of-cardiovascular-toxicity-of-vascular-endothelial-growth-factor-inhibitors
#7
Yen-Chou Chen, Cheng-Chih Chung, Yung-Kuo Lin, Yi-Jen Chen
Vascular endothelial growth factor (VEGF) inhibitors, including monoclonal antibodies and tyrosine kinase inhibitors (TKIs), are important as anticancer treatments through curbing tumour angiogenesis and growth. VEGF inhibitors have significant cardiovascular effects. By blocking VEGF receptors, ligands, or signal pathways, VEGF inhibitors disturb the balance between vasodilation and vasoconstriction, undermine endothelial cell integrity, and activate cardiomyocyte apoptosis. VEGF inhibitors increase risks of hypertension, heart failure, thromboembolism and arrhythmia...
September 27, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28892413/enhancing-the-real-world-prediction-of-cardiovascular-events-and-major-bleeding-with-the-cha2ds2-vasc-and-has-bled-scores-using-multiple-biomarkers
#8
Vanessa Roldán, José Miguel Rivera-Caravaca, Alena Shantsila, Amaya García-Fernández, María Asunción Esteve-Pastor, Juan Antonio Vilchez, Marta Romera, Mariano Valdés, Vicente Vicente, Francisco Marín, Gregory Y H Lip
BACKGROUND: Atrial fibrillation (AF)-European guidelines suggest the use of biomarkers to stratify patients for stroke and bleeding risks. We investigated if a multibiomarker strategy improved the predictive performance of CHA2DS2-VASc and HAS-BLED in anticoagulated AF patients. METHODS: We included consecutive patients stabilized for six months on vitamin K antagonists (INRs 2.0-3.0). High sensitivity troponin T, NT-proBNP, interleukin-6, von Willebrand factor concentrations and glomerular filtration rate (eGFR; using MDRD-4 formula) were quantified at baseline...
September 18, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28879775/direct-indirect-and-total-bilirubin-and-risk-of-incident-coronary-heart-disease-in-the-dongfeng-tongji-cohort
#9
Xuefeng Lai, Qin Fang, Liangle Yang, Xuguang Chen, Hao Wang, Lin Ma, Wenting Guo, Miao Liu, Handong Yang, Ce Zhang, Xiulou Li, Xinwen Min, Jing Yuan, Mei-An He, Tangchun Wu, Xiaomin Zhang
BACKGROUND: Total bilirubin (TBIL) is known to be inversely associated with coronary heart disease (CHD) risk, however, whether this association is dose-response remains inconsistent and it is unclear which subtype of bilirubin is responsible for the potential protective effect. METHODS: We included 12, 097 participants who were free of CHD, stroke, cancer and potential liver, biliary and renal diseases at baseline from Sep. 2008 to June 2010 and were followed-up until Oct...
September 7, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28847158/baseline-fatty-acids-food-groups-a-diet-score-and-50-year-all-cause-mortality-rates-an-ecological-analysis-of-the-seven-countries-study
#10
Alessandro Menotti, Daan Kromhout, Paolo Emilio Puddu, Adalberta Alberti-Fidanza, Peter Hollman, Anthony Kafatos, Hanna Tolonen, Hisashi Adachi, David R Jacobs
OBJECTIVES: This analysis deals with the ecologic relationships of dietary fatty acids, food groups and the Mediterranean Adequacy Index (MAI, derived from 15 food groups) with 50-year all-cause mortality rates in 16 cohorts of the Seven Countries Study. MATERIAL AND METHODS: A dietary survey was conducted at baseline in cohorts subsamples including chemical analysis of food samples representing average consumptions. Ecologic correlations of dietary variables were computed across cohorts with 50-year all-cause mortality rates, where 97% of men had died...
September 6, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28829201/correction-to-stadler-et%C3%A2-al-association-of-sleep-disordered-breathing-with-diabetes-associated-kidney-disease
#11
(no author information available yet)
No abstract text is available yet for this article.
August 22, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28805463/oxygen-uptake-at-aerobic-threshold-is-inversely-associated-with-fatal-cardiovascular-and-all-cause-mortality-events
#12
Setor K Kunutsor, Sudhir Kurl, Hassan Khan, Francesco Zaccardi, Rainer Rauramaa, Jari A Laukkanen
PURPOSE: We aimed to assess the associations of oxygen uptake at aerobic threshold (VO2 at AT) with cardiovascular and all-cause mortality. DESIGN: VO2 at AT was assessed in 1663 middle-aged men in a cohort study. Hazard ratios (HRs) were calculated for sudden cardiac death (SCD), fatal coronary heart disease (CHD) and cardiovascular disease (CVD) and all-cause mortality. RESULTS: During a median follow-up of 25.6 years, 138 SCDs, 209 fatal CHDs, 333 fatal CVDs and 719 all-cause mortality events occurred...
August 22, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28797175/role-of-lipids-and-intraplaque-hypoxia-in-the-formation-of-neovascularization-in-atherosclerosis
#13
Dimitry A Chistiakov, Alexandra A Melnichenko, Veronika A Myasoedova, Andrey V Grechko, Alexander N Orekhov
According to the current paradigm, chronic vascular inflammation plays a central role in the pathogenesis of atherosclerosis. The plaque progression is typically completed with rupture and subsequent acute cardiovascular complications. Previously, the role of adventitial vasa vasorum in atherogenesis was underestimated. However, investigators then revealed that vasa vasorum neovascularization can be observed when no clinical manifestation of atherosclerosis is present. Vasa vasorum is involved in various proatherogenic processes such as intimal accumulation of inflammatory leukocytes, intimal thickening, necrotic core formation, intraplaque haemorrhage, lesion rupture and atherothrombosis...
August 22, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28786719/nutraceutical-approaches-to-metabolic-syndrome
#14
Cesare R Sirtori, Chiara Pavanello, Laura Calabresi, Massimiliano Ruscica
Metabolic Syndrome (MetS), affecting at least 30% of adults in the Western World, is characterized by three out of five variables, from high triglycerides, to elevated waist circumference and blood pressure. MetS is not characterized by elevated cholesterolemia, but is rather the consequence of a complex interaction of factors generally leading to increased insulin resistance. Drug treatments are of difficult handling, whereas well-characterized nutraceuticals may offer an effective alternative. Among these, functional foods, e...
August 22, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28844171/a-clinical-decision-making-algorithm-for-penicillin-allergy
#15
Angèle Soria, Elodie Autegarden, Emmanuelle Amsler, Hafida Gaouar, Amandine Vial, Camille Francès, Jean-Eric Autegarden
BACKGROUND: About 10% of subjects report suspected penicillin allergy, but 85-90% of these patients are not truly allergic and could safely receive beta-lactam antibiotics Objective: To design and validate a clinical decision-making algorithm, based on anamnesis (chronology, severity, and duration of the suspected allergic reactions) and reaching a 100% sensitivity and negative predictive value, to assess allergy risk related to a penicillin prescription in general practise. STUDY DESIGN AND METHODS: All patients were included prospectively and explorated based on ENDA/EAACI recommendations...
December 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28782992/pdtcm-a-systems-pharmacology-platform-of-traditional-chinese-medicine-for-psoriasis
#16
Dongmei Wang, Jiangyong Gu, Wei Zhu, Fang Luo, Lirong Chen, Xiaojie Xu, Chuanjian Lu
INTRODUCTION: Psoriasis is a refractory skin disorder, and usually requires a lifetime control. Traditional Chinese medicine (TCM) is effective and safe for this disease. However, the cellular and molecular mechanisms of TCM remedies for psoriasis are still not fully understood. TCM contains numerous natural products. Natural products have historically been invaluable as a resource of therapeutic agents. Yet, there is no integrated information about active compounds of TCM for psoriasis...
December 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28537435/comparison-of-treatments-in-patients-with-distal-humerus-intercondylar-fracture-a-systematic-review-and-meta-analysis
#17
Hongwei Chen, Dacheng Li, Jun Zhang, Xinwei Xiong
INTRODUCTION: Distal humerus intercondylar fractures are intra-articular comminuted fractures of the elbow that involve soft tissue injury. We evaluate different surgical approaches and elbow functional outcomes in the treatment of distal humerus fracture. MATERIALS AND METHODS: Medline, Cochrane, EMBASE, Google Scholar databases were searched up to 29 July 2016. All studies had to have evaluated the treatment of patients with intercondylar fractures of the distal humerus...
November 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28521523/sepsis-in-internal-medicine-wards-current-knowledge-uncertainties-and-new-approaches-for-management-optimization
#18
Vincenzo Zaccone, Alberto Tosoni, Giovanna Passaro, Carla Vincenza Vallone, Michele Impagnatiello, Domenica Donatella Li Puma, Salvatore De Cosmo, Raffaele Landolfi, Antonio Mirijello
Sepsis represents a global health problem in terms of morbidity, mortality, social and economic costs. Although usually managed in Intensive Care Units, sepsis showed an increased prevalence among Internal Medicine wards in the last decade. This is substantially due to the ageing of population and to multi-morbidity. These characteristics represent both a risk factor for sepsis and a relative contra-indication for the admission to Intensive Care Units. Although there is a lack of literature on the management of sepsis in Internal Medicine, the outcome of these patients seems to be gradually improving...
November 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28409656/condomless-sex-and-hiv-transmission-among-serodifferent-couples-current-evidence-and-recommendations
#19
Alan Koff, Carole Goldberg, Onyema Ogbuagu
Human immunodeficiency virus (HIV) infection remains a global pandemic. The primary driver of HIV incidence is sexual transmission between serodifferent individuals. Condoms, when used consistently and correctly, are effective at preventing sexually transmitted HIV infections and are considered an integral component of a comprehensive approach to HIV prevention. However, the demonstrated effectiveness of antiretroviral therapy (ART) to prevent HIV transmission, known as treatment as prevention and of pre-exposure prophylaxis, have raised an intriguing dilemma on the necessity and additive preventive benefit of condom use among individuals in serodifferent relationships utilizing these prevention strategies...
September 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28358246/effects-of-direct-renin-inhibition-versus-angiotensin-ii-receptor-blockade-on-angiotensin-profiles-in-non-diabetic-chronic-kidney-disease
#20
Marlies Antlanger, Sebastian Bernhofer, Johannes J Kovarik, Chantal Kopecky, Christopher C Kaltenecker, Oliver Domenig, Marko Poglitsch, Marcus D Säemann
BACKGROUND: Direct renin inhibition (DRI) is clinically inferior to other blockers of the renin-angiotensin system (RAS). Thus far, the underlying molecular causes of this finding remain unknown. METHODS: Twenty four patients with non-diabetic chronic kidney disease (CKD) stages III-IV and albuminuria were randomized to DRI or angiotensin receptor blocker (ARB). Employing a novel mass-spectrometry method, the concentrations of renin, aldosterone and plasma angiotensin peptides [Ang I, Ang II, Ang-(1-7), Ang-(1-5), Ang-(2-8), Ang-(3-8)] were quantified before and after an 8-week treatment...
September 2017: Annals of Medicine
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