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Annals of Medicine

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https://www.readbyqxmd.com/read/29637787/prevalence-of-metabolic-syndrome-among-middle-aged-and-elderly-adults-in-china-current-status-and-temporal-trends
#1
Wenzhen Li, Fujian Song, Xiaojun Wang, Longde Wang, Dongming Wang, Xiaoxv Yin, Shiyi Cao, Yanhong Gong, Wei Yue, Feng Yan, Hong Zhang, Zhenjie Sheng, Zhihong Wang, Zuxun Lu
BACKGROUND: Metabolic syndrome (MetS) is a cluster of major risk factors for cardiovascular diseases. We aimed to estimate prevalence and distribution of MetS among middle-aged and elderly adults in China. METHODS: The present analysis used data from a national study in 2014-2015. We defined MetS by different definitions, and compared results of the present study and previous nationally representative studies to illustrate possible temporal changes in MetS prevalence...
April 11, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29629575/adult-hospital-admissions-associated-with-multiple-sclerosis-in-finland-in-2004-2014
#2
Anna-Leena Pirttisalo, Jussi O T Sipilä, Merja Soilu-Hänninen, Päivi Rautava, Ville Kytö
INTRODUCTION: Treatment of multiple sclerosis (MS) has developed significantly and several new immunotherapeutic drugs have become available in Finland since 2004. We studied whether this is associated with changes in hospital admission frequencies and healthcare costs and whether admission rates due to infection have increased. METHODS: The national Care Register for Health Care was searched for all discharges from neurological, medical, surgical, neurosurgical and intensive care units with MS as a primary diagnosis or an auxiliary diagnosis for primary infection diagnosis in 2004-2014...
April 9, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29616838/why-all-randomised-controlled-trials-produce-biased-results
#3
Alexander Krauss
BACKGROUND: Randomised controlled trials (RCTs) are commonly viewed as the best research method to inform public health and social policy. Usually they are thought of as providing the most rigorous evidence of a treatment's effectiveness without strong assumptions, biases and limitations. OBJECTIVE: This is the first study to examine that hypothesis by assessing the 10 most cited RCT studies worldwide. DATA SOURCES: These 10 RCT studies with the highest number of citations in any journal (up to June 2016) were identified by searching Scopus (the largest database of peer-reviewed journals)...
April 4, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29608110/fitting-the-right-non-vitamin-k-antagonist-oral-anticoagulant-to-the-right-patient-with-non-valvular-atrial-fibrillation-an-evidence-based-choice
#4
Yanguang Li, Daniele Pastori, Gregory Yh Lip
Atrial fibrillation (AF) is the most prevalent arrhythmia and is associated with an increased risk of ischemic stroke (IS) and systemic embolism (SE). Stroke prevention is a key element for the overall management of AF patients. The non-vitamin K antagonist oral anticoagulants (NOACs), such as dabigatran, rivaroxaban, apixaban and edoxaban, are at least as effective as warfarin in reducing IS/SE with a lower rate of major bleeding. Various analyses from the large Phase III randomised trials demonstrated different efficacy and safety of NOACs in specific subgroups of patients...
April 2, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29578362/molecular-aspects-of-hypercholesterolemia-treatment-current-perspectives-and-hopes
#5
Najmeh Ahangari, Majid Ghayour Mobarhan, Amir Hosein Sahebkar, Alireza Pasdar
BACKGROUND: Hypercholesterolemia is a pathological condition which has been reported in 39% of the worlds' adult population. We aimed to review molecular aspects of current and novel therapeutic approaches based on low-density lipoprotein cholesterol lowering strategies. METHODS: Searching through PubMed and Scopus databases for relative articles using the following keywords have been done: Hypercholesterolemia, Therapy, lipid-lowering drugs, low-density lipoprotein cholesterol...
March 26, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29537306/deciphering-metabonomics-biomarkers-targets-interactions-for-psoriasis-vulgaris-by-network-pharmacology
#6
Jiangyong Gu, Li Li, Dongmei Wang, Wei Zhu, Ling Han, Ruizhi Zhao, Xiaojie Xu, Chuanjian Lu
OBJECTIVES: Psoriasis vulgaris is a chronic inflammatory and immune-mediated skin disease. 44 metabonomics biomarkers were identified by high-throughput liquid chromatography coupled to mass spectrometry in our previous work, but the roles of metabonomics biomarkers in the pathogenesis of psoriasis is unclear. METHODS: The metabonomics biomarker-enzyme network was constructed. The key metabonomics biomarkers and enzymes were screened out by network analysis. The binding affinity between each metabonomics biomarker and target was calculated by molecular docking...
March 23, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29537309/pancreatic-cancer-subtypes-a-roadmap-for-precision-medicine
#7
Carolina Torres, Paul J Grippo
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cause of cancer-related deaths by 2020. Although it has traditionally been approached as a disease, accumulated evidences point to the clinical heterogeneity of this disease, which translate into disparity in outcomes among the patients. Much emphasis has been put into patient classification introducing a platform for more tailored therapies. In the last 10 years, there have been important advances in the understanding of the molecular pathogenesis of PDAC, which has culminated with a comprehensive integrated genomic analysis from RNA expression profiles...
March 22, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29513108/hereditary-angioedema-due-to-c1-inhibitor-deficiency-in-macedonia-clinical-characteristics-novel-serping1-mutations-and-genetic-factors-modifying-the-clinical-phenotype
#8
Vesna Grivčeva-Panovska, Mitja Košnik, Peter Korošec, Slađana Andrejević, Ljerka Karadža-Lapić, Matija Rijavec
OBJECTIVE: Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare disease, characterized by swellings. We aimed to characterize on a clinical and molecular basis C1-INH-HAE patients in the Republic of Macedonia. RESULTS: All 15 patients from six unrelated families were diagnosed with C1-INH-HAE type I, with a mean age of symptom onset of 11 years and an average delay of diagnosis of 7 years. Patients reported on average 31 angioedema attacks/year, with a median clinical severity score (CSS) of 7...
March 7, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29473427/glucocorticoid-sensitivity-and-inflammatory-status-of-peripheral-blood-mononuclear-cells-in-patients-with-coronary-artery-disease
#9
Simon Jönsson, Anna K Lundberg, Rosanna W S Chung, Lena Jonasson
OBJECTIVE: Mechanisms behind sustained inflammation in patients with coronary artery disease (CAD) are not clarified but hypothalamus-pituitary-adrenal (HPA) axis dysfunction may have a role. Here, we investigated whether inflammatory status of peripheral blood mononuclear cells (PBMCs) was associated with altered glucocorticoid sensitivity in CAD patients. METHODS: In 55 CAD patients and 30 controls, mRNA levels of GR-α, GR-β, NF-κB, IκBα, MMP-9, and TIMP-1 were measured in PBMCs...
February 23, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29448840/inverse-association-between-serum-albumin-and-future-risk-of-venous-thromboembolism-interrelationship-with-high-sensitivity-c-reactive-protein
#10
Setor K Kunutsor, Samuel Seidu, Devvrat T Katechia, Jari A Laukkanen
PURPOSE: We aimed to assess the prospective association of serum albumin with venous thromboembolism (VTE) risk and evaluate if the association is independent of or modified by inflammation, as measured by high sensitivity C-reactive protein (hsCRP). DESIGN: We analysed data of 2176 men aged 42-61 years free from VTE in the Kuopio Ischemic Heart Disease study, with serum albumin concentrations measured at baseline using Coulter's bromocresol purple colorimetric assays...
February 20, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29473759/contribution-of-non-traditional-lipid-profiles-to-reduced-glomerular-filtration-rate-in-h-type-hypertension-population-of-rural-china
#11
Haoyu Wang, Zhao Li, Xiaofan Guo, Yintao Chen, Shuang Chen, Yichen Tian, Yingxian Sun
BACKGROUND: Despite current interest in the unfavourable impact of non-traditional lipid profiles on cardiovascular disease, information regarding its relations to reduced glomerular filtration rate (GFR) in H-type hypertension population has not been systemically elucidated. METHODS: Analyses were based upon a cross-sectional study of 3259 participants with H-type hypertension who underwent assessment of biochemical, anthropometric and blood pressure values. Reduced GFR was considered if meeting estimated GFR <60 ml/min/1...
May 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29457514/relapse-of-bullous-pemphigoid-an-update-on-this-stubborn-clinical-problem
#12
Yiman Wang, Xuming Mao, Yanhong Wang, Yueping Zeng, Yidi Liu, Hongzhong Jin, Li Li
Bullous pemphigoid (BP) is a chronic autoimmune blistering disorder that has a predilection for the elderly. It is characterized by a poor prognosis due to its high mortality rate and the tendency to relapse. The relapse rate of BP ranges from 27.87% to 53% after disease remission, while the majority of relapses occur early (within 6 months) during remission. Clinical interventions aimed to prevent early relapses could reduce potential complications from first-line treatment and make follow-up care easier for clinicians in practice, thus improving the prognosis of BP and the quality of patients' lives...
May 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29363985/pulmonary-hypertension-and-exercise-training-a-synopsis-on-the-more-recent-evidences
#13
Massimo Leggio, Augusto Fusco, Massimo Armeni, Stefania D'Emidio, Paolo Severi, Salvatore Calvaruso, Giorgio Limongelli, Luca Sgorbini, Maria Grazia Bendini, Andrea Mazza
The benefits of exercise training in virtually all humans, including those with a clinically stable chronic disease are numerous. The potential value lies in the fact that functional capacity is oftentimes significantly compromised. Exercise training not only play a role in reversing some of the pathophysiologic processes associated with chronic diseases but also improves clinical trajectory. Given the significant pathologic consequences associated with pulmonary hypertension and its implications for deteriorating right ventricular function as well as the perceived potential for a precipitous and possibly critical drop in cardiac output during periods of physical exertion, exercise training was historically not recommended for these patients...
May 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29338438/challenges-in-adult-vaccination
#14
Eduardo de Gomensoro, Giuseppe Del Giudice, T Mark Doherty
Life-long primary prevention interventions beginning and continuing throughout an individual's lifetime are increasingly seen as key to meeting the global healthcare challenges that accompany demographic changes - a concept referred to as "Healthy aging". In this perspective, vaccination is seen as part of a triad, together with healthy diet and exercise. Current adult vaccine coverage is lower than target vaccination rates in most developed countries, and so vaccine preventable diseases continue to present a substantial burden on health and healthcare resources, especially in older individuals...
May 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29316825/on-surmounting-the-barriers-to-hpv-vaccination-we-can-do-better
#15
Aria C Attia, Judith Wolf, Ana E Núñez
The major impediment to increased human papillomavirus (HPV) vaccination coverage in young males and females is lack of health care provider recommendation. Despite its efficacy in preventing cervical cancer, HPV vaccination in females (49.5%) and males (37.5%) ages 13 through 17 falls well below the Centers for Disease Control and Prevention's (CDC) Healthy People 2020 target of 80% coverage. Parents' willingness to vaccinate their child has been shown to be much higher when physicians share personal vaccination decisions for their own children as well as what other parents have done at that particular clinic...
May 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29308916/maternal-immunization-where-are-we-now-and-how-to-move-forward
#16
Ivo Vojtek, Ilse Dieussaert, T Mark Doherty, Valentine Franck, Linda Hanssens, Jacqueline Miller, Rafik Bekkat-Berkani, Walid Kandeil, David Prado-Cohrs, Andrew Vyse
Pregnancy and the postpartum period are associated with elevated risks to both mother and infant from infectious disease. Vaccination of pregnant women, also called maternal immunization, has the potential to protect pregnant women, foetuses and infants from several vaccine-preventable diseases. Maternal immunoglobulin G antibodies are actively transferred through the placenta to provide passive immunity to new-borns during the first months of life, until the time for infant vaccinations or until the period of greatest susceptibility has passed...
May 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29291629/longer-time-spent-in-bed-attempting-to-sleep-is-associated-with-rapid-renal-function-decline-the-dongfeng-tongji-cohort-study
#17
Yizhun Li, Liangle Yang, Hao Wang, Haijing Jiang, Gaokun Qiu, Yiyi Liu, Yang Xiao, Handong Yang, Tangchun Wu, Xiaomin Zhang
INTRODUCTION: Prospective evidence on the relation between time in bed and renal dysfunction remains limited. We aimed to investigate the association of time spent in bed attempting to sleep (TSBS) with renal function decline in a middle-aged and elderly Chinese population. METHODS: About 16,733 eligible participants with a mean age of 62.3 years at baseline were included. Rapid renal function decline was defined as (baseline eGFR - revisit eGFR)/years of follow-up ≥5 mL/min per 1...
March 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29237304/the-role-of-mitochondrial-dysfunction-in-cardiovascular-disease-a-brief-review
#18
Dimitry A Chistiakov, Tatiana P Shkurat, Alexandra A Melnichenko, Andrey V Grechko, Alexander N Orekhov
Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Proper mitochondrial function is necessary in tissues and organs that are of high energy demand, including the heart. Mitochondria are very sensitive to nutrient and oxygen supply and undergo metabolic adaptation to the changing environment. In CVD, such an adaptation is impaired, which, in turn, leads to a progressive decline of the mitochondrial function associated with abnormalities in the respiratory chain and ATP synthesis, increased oxidative stress, and loss of the structural integrity of mitochondria...
March 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29172794/mortality-in-patients-with-atrial-fibrillation-and-common-co-morbidities-a-cohort-study-in-primary-care
#19
Per Wändell, Axel C Carlsson, Martin J Holzmann, Johan Ärnlöv, Jan Sundquist, Kristina Sundquist
OBJECTIVE: To study the association between cardiovascular co-morbidities and mortality risk in primary care patients with atrial fibrillation. METHODS: The study population included all adults (n = 12,283) ≥ 45 years diagnosed with AF at 75 primary care centres in Sweden between 2001 and 2007. The outcome was mortality (until 2010) and data were explored for co-morbidities using Cox regression with hazard ratios (HRs). Analyses were performed stratified by sex and by age-group (45-64, 65-74 and ≥75 years of age) with adjustment for age, socio-economic factors and relevant co-morbidities...
March 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29172780/understanding-modern-day-vaccines-what-you-need-to-know
#20
Volker Vetter, Gülhan Denizer, Leonard R Friedland, Jyothsna Krishnan, Marla Shapiro
Vaccines are considered to be one of the greatest public health achievements of the last century. Depending on the biology of the infection, the disease to be prevented, and the targeted population, a vaccine may require the induction of different adaptive immune mechanisms to be effective. Understanding the basic concepts of different vaccines is therefore crucial to understand their mode of action, benefits, risks, and their potential real-life impact on protection. This review aims to provide healthcare professionals with background information about the main vaccine designs and concepts of protection in a simplified way to improve their knowledge and understanding, and increase their confidence in the science of vaccination ( Supplementary Material )...
March 2018: Annals of Medicine
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