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Annals of Medicine

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https://www.readbyqxmd.com/read/27685190/pathogenesis-of-ligaments-ossification-in-spondyloarthritis-insights-and-doubts
#1
Anna Neve, Nicola Maruotti, Addolorata Corrado, Francesco Paolo Cantatore
Despite intensive research in spondyloarthritis pathogenesis, some important questions still remain unanswered, particularly concerning enthesis new bone formation. Several evidences suggest that it prevalently occurs by endochondral ossification, however it remains to identify factors that can induce and influence its initiation and progression. Recent progress, achieved in animal models and in vitro and genetic association studies, has led us to hypothesize that several systemic factors (adipokines and gut hormones) and local factors (BMP and Wnt signaling) as well as angiogenesis and mechanical stress are involved...
November 12, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27685024/the-use-of-echocardiography-for-the-non-invasive-evaluation-of-coronary-artery-disease
#2
Cesare R Sirtori, Fabien Labombarda, Samuela Castelnuovo, Rebecca Perry
In the Western world, there are now millions of patients who undergo clinical procedures that evaluate coronary artery status each year. Methods span from direct imaging using angiography, computerized tomography, to nuclear magnetic imaging as well as to functional studies, such as positron emission tomography. These techniques have provided significant information to physicians, but there is still need for an improved accessibility. Angiographic methods are expensive and expose the patient to significant amounts of radiation, undesirable in younger patients...
November 12, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27813419/anti-interleukin-2-receptor-antibodies-for-the-prevention-of-rejection-in-liver-transplant-recipients-a-systematic-review-and-meta-analysis
#3
Yi Zhang, Weidong Jin, Xun Cai
BACKGROUND: Antibody induction therapy aims to prevent acute cellular rejection by reducing T-cell proliferation and activation. We evaluated the efficacy and side effects of two anti-interleukin-2 receptor antibodies (IL2RA), basiliximab and daclizumab, for prevention of liver transplant rejection in adult patients. METHODS: Randomized controlled trials on basiliximab or daclizumab were identified by searching multiple databases and reference lists published up to July, 2015...
November 4, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27595291/increased-serum-c-reactive-protein-levels-are-associated-with-shorter-survival-and-development-of-second-cancers-in-chronic-lymphocytic-leukemia
#4
Yair Herishanu, Aaron Polliack, Shani Shenhar-Tsarfaty, Ronit Weinberger, Ram Gelman, Tomer Ziv-Baran, David Zeltser, Itzhak Shapira, Sholomo Berliner, Ori Rogowski
BACKGROUND: Chronic lymphocytic leukemia (CLL) is characterized by a heterogeneous clinical course, ranging from stable to more aggressive disease. Herein, we determined the prognostic significance of serum C-reactive protein (CRP) levels in patients with CLL Methods: A retrospective cohort study reviewing the records of 107 consecutive treatment naïve patients with CLL and a control group comprised of apparently healthy individuals attending for periodic health examinations. RESULTS: The median CRP level of patients with CLL was 0...
November 3, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27791388/a-narrative-review-about-blood-laboratory-testing-for-early-prediction-of-preeclampsia-chasing-the-finish-line-or-at-the-starting-blocks
#5
Martina Montagnana, Elisa Danese, Giuseppe Lippi, Cristiano Fava
Preeclampsia (PE) affects 2-8% of pregnancies worldwide, thus representing an important cause of maternal and neonatal morbidity, up to death. Many studies have been designed to identify putative biomarkers for accurate and timely diagnosing PE, but only some of them were focused on specific and sensitive biomarkers for early prediction of this life-threatening condition. In particular, some prospective studies aimed to investigate the predictive role of circulating biomarkers before 20 weeks of gestation in the general pregnant population yielded conflicting results...
October 28, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27786563/non-invasive-pre-implantation-aneuploidy-screening-and-diagnosis-of-beta-thalassemia-ivsii654-mutation-using-spent-embryo-culture-medium
#6
WeiQiang Liu, JianQiao Liu, HongZi Du, JiaWei Ling, XiaoFang Sun, DunJin Chen
BACKGROUND: Cell-free nuclear DNA has been isolated from spent embryo culture medium. Whether this small amount of DNA can be amplified at the whole genome level and the concordance rate of karyotypes and specific alleles between biopsied cells and media has not been evaluated. METHODS: Seven couples were recruited, 88 donated embryos and their corresponding media were collected for whole genome amplification (WGA). The efficiency of WGA, the concordance of chromosome status and the HBB gene IVSII654 allele between biopsied cells and media were investigated...
October 27, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27786555/seasonality-of-stroke-in-finland
#7
Jussi Sipilä, Jori O Ruuskanen, Tommi Kauko, Päivi Rautava, Ville Kytö
INTRODUCTION: The burden of stroke is increasing globally. Reports on seasonal variations in stroke occurrence are conflicting and long-term data is absent. METHODS: A retrospective cohort study using discharge registry data of all acute stroke admissions in Finland in 2004-2014 for patients ≥18 years age. 97018 admissions for ischemic stroke (IS) were included, 18252 admissions for intracerebral haemorrhage (ICH) and 11271 admissions for subarachnoid haemorrhage (SAH)...
October 27, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27786552/use-of-antidementia-drugs-and-risk-of-pneumonia-in-older-persons-with-alzheimer-s-disease
#8
Pasi Lampela, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Piia Lavikainen, Sirpa Hartikainen, Heidi Taipale
INTRODUCTION: Persons with Alzheimer's disease are at an increased risk of pneumonia, but the comparative risks during specific antidementia treatments are not known. We compared the risk of pneumonia in use of donepezil, rivastigmine (oral, transdermal), galantamine and memantine. PATIENTS AND METHODS: We used data from a nationwide cohort of community-dwelling individuals diagnosed with Alzheimer's disease during 2005-2011 in Finland, who initiated monotherapy with acetylcholinesterase inhibitor or memantine (n = 65481)...
October 27, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27764976/clinical-usefulness-of-the-oxford-classification-in-determining-immunosuppressive-treatment-in-iga-nephropathy
#9
Chang-Yun Yoon, Jeong Hae Kie, Tae Ik Chang, Ea Wha Kang, Youn Kyung Kee, Hyoungnae Kim, Seohyun Park, Hae-Ryong Yun, Su-Young Jung, Jong Hyun Jhee, Young Eun Kwon, Hyung Jung Oh, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND: The Oxford classification has been widely used in IgA nephropathy. However, its clinical usefulness of determining immunosuppression is unknown. AIMS: Whether the Oxford classification could predict the development of proteinuria ≥1 g/g Cr and worsening kidney function, as well as the clinical efficacy of corticosteroid treatment according to each histologic variable of the Oxford-MEST. METHODS: We included 377 patients with early-stage IgA nephropathy...
October 21, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27764973/predictors-of-cardiorespiratory-fitness-in-female-and-male-adults-with-different-body-mass-index-national-health-and-nutrition-examination-survey-1999-2004-dataset
#10
Liang Chen, Jian Kuang, Jian-Hao Pei, Hong-Mei Chen, Zhong Chen, Zhong-Wen Li, Hua-Zhang Yang, Xiao-Ying Fu, Long Wang, Zhi-Jiang Chen, Shui-Qing Lai, Shu-Ting Zhang
BACKGROUND: The aim of this study was to explore factors affecting cardiorespiratory fitness in males and females with different body mass index. METHODS: The National Health and Nutrition Examination Survey 1999-2004 data were used for this retrospective study. Estimated maximal oxygen uptake (VO2max) is surrogate for cardiorespiratory fitness (CRF). Univariate and multivariate linear regression analyses were performed to explore whether study variables were associated with estimated VO2max stratified by gender and BMI categories...
October 21, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27764967/cardiovascular-fitness-in-young-males-and-risk-of-unprovoked-venous-thromboembolism-in-adulthood
#11
Bengt Zöller, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist
BACKGROUND: Whether high cardiovascular fitness is associated with reduced risk of venous thromboembolism (VTE) is unknown. The present study aims to determine whether high cardiovascular fitness reduces the risk of VTE. METHODS: A Swedish cohort of male conscripts (n = 773925) born in 1954-1970 with no history of previous VTE were followed from enlistment (1972-1990) until 2010. Data on cardiovascular fitness using a cycle ergonometric test (maximal aerobic workload in Watt [Wmax]) at conscription were linked with national hospital register data and the Multi-Generation Register...
October 21, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27763781/markers-of-atherosclerosis-in-patients-with-cushing-s-syndrome-a-meta-analysis-of-literature-studies
#12
Roberta Lupoli, Pasquale Ambrosino, Anna Tortora, Livia Barba, Gelsy Arianna Lupoli, Matteo Nicola Dario Di Minno
BACKGROUND: Several studies reported an increased cardiovascular (CV) risk in Cushing's syndrome (CS). We performed a meta-analysis on the impact of CS on major markers of atherosclerosis. METHODS: Studies on intima-media thickness (IMT), carotid plaques prevalence and flow-mediated dilation (FMD) in CS patients and controls were searched in the PubMed, Web of Science, Scopus and EMBASE. Differences between cases and controls were expressed as mean difference (MD) with 95% confidence intervals (95%CI) for continuous variables, and as Odds Ratio (OR) with 95%CI for dichotomous variables...
October 20, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27763780/systemic-effects-of-controlled-exposure-to-diesel-exhaust-a-meta-analysis-from-randomized-controlled-trials
#13
Jefferson Luis Vieira, Francisco Yuri Macedo, Alexandre Miguel Benjo, Guilherme V Guimarães, Johanna Paola Contreras, Edimar A Bocchi
INTRODUCTION: Ambient air pollution is associated with adverse cardiovascular events. This meta-analysis aimed to investigate the short-term association between air pollution and cardiovascular effects on healthy volunteers. METHODS: We searched databases to identify randomized trials with controlled human exposures to either of two models for studying ambient particulate matter: diesel-exhaust or concentrated ambient particles. Estimates of size effect were performed using standardized mean difference (SMD)...
October 20, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27763767/drug-burden-index-and-change-in-cognition-over-time-in-community-dwelling-older-men-the-champ-study
#14
Kris M Jamsen, Danijela Gnjidic, Sarah N Hilmer, Jenni Ilomäki, David G Le Couteur, Fiona M Blyth, David J Handelsman, Vasi Naganathan, Louise M Waite, Robert G Cumming, J Simon Bell
OBJECTIVE: Anticholinergic and sedative medications are associated with acute cognitive impairment but the long-term impact on change in cognition is unclear. This study investigated the effect of anticholinergic and sedative medications, quantified using the Drug Burden Index (DBI), on change in cognition over time in community-dwelling older men. METHODS: This was a prospective cohort study of men aged ≥70 years in Sydney, Australia. DBI was assessed at baseline, two and five years...
October 20, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27690662/titanium-nitride-oxide-coated-coronary-stents-insights-from-the-available-evidence
#15
Pasi P Karjalainen, Wail Nammas
Coating of stent surface with a biocompatible material is suggested to improve stent safety profile. A proprietary process was developed to coat titanium-nitride-oxide on the stent surface, based on plasma technology that uses the nano-synthesis of gas and metal. Preclinical in vitro and in vivo investigation confirmed blood compatibility of titanium (nitride-) oxide films. Titanium-nitride-oxide-coated stents demonstrated a better angiographic outcome, compared with bare-metal stents at mid-term follow-up; however, they failed to achieve non-inferiority for angiographic outcome versus second-generation drug-eluting stents...
October 3, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27690642/regulatory-t-cd4-cd25-lymphocytes-increase-in-symptomatic-carotid-artery-stenosis
#16
Flavia Del Porto, Noemi Cifani, Maria Proietta, Sara Perrotta, Raffaele Dito, Cira di Gioia, Raffaella Carletti, Luigi Rizzo, Gianluigi Orgera, Michele Rossi, Livia Ferri, Luigi Tritapepe, Maurizio Taurino
BACKGROUND: Atherosclerosis is a multifactorial disease characterized by an immune-inflammatory remodeling of the arterial wall. Tregs and Th17 subpopulations are detectable inside atherosclerotic plaque, however their behavior in symptomatic carotid artery stenosis (CAS) is not fully elucidated. The aim of this study was to evaluate Th17 and Tregs subsets and their ratio in patients affected by symptomatic and asymptomatic CAS. METHODS: 14 patients with symptomatic CAS (CAS-S group), 41 patients with asymptomatic CAS (CAS-A group), 32 subjects with traditional cardiovascular risk factors (RF group) and 10 healthy subjects (HS group) were enrolled...
October 3, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27689859/effect-of-uric-acid-lowering-therapy-on-blood-pressure-systematic-review-and-meta-analysis
#17
Li-Hui Qu, Hong Jiang, Jiang-Hua Chen
BACKGROUND: The purpose of this meta-analysis was to determine if uric acid-lowering therapy is associated with a decrease in blood pressure (BP) and serum creatinine levels. MATERIALS AND METHODS: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until June 29, 2016, with keywords: uric-acid-lowering therapy, allopurinol, febuxostat, uricosuric, blood pressure. Only randomized controlled trials were included. The primary outcomes were reduction in systolic BP (SBP) and diastolic BP (DBP), and secondary was reduction in serum creatinine level...
September 30, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27684365/exercise-cardiac-power-and-the-risk-of-coronary-heart-disease-and-cardiovascular-mortality-in-men
#18
Sudhir Kurl, Timo Mäkikallio, Sae Young Jae, Kimmo Ronkainen, Jari A Laukkanen
PURPOSE: The aim of this study was to examine the relationship of exercise cardiac power (ECP), defined as a ratio of directly measured maximal oxygen uptake with peak systolic blood pressure during exercise, with the risk of mortality from coronary heart diseases (CHD) and cardiovascular diseases (CVD). DESIGN: Population-based cohort study with an average follow-up of 25 years from eastern Finland. About 2358 men at baseline participated in exercise stress test and 182 CHD and 302 CVD deaths occurred...
September 29, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27684300/are-12-lead-ecg-findings-associated-with-the-risk-of-cardiovascular-events-after-ischemic-stroke-in-young-adults
#19
Jani Pirinen, Jukka Putaala, Karoliina Aarnio, Aapo L Aro, Juha Sinisalo, Markku Kaste, Elena Haapaniemi, Turgut Tatlisumak, Mika Lehto
INTRODUCTION: Ischemic stroke (IS) in a young patient is a disaster and recurrent cardiovascular events could add further impairment. Identifying patients with high risk of such events is therefore important. The prognostic relevance of ECG for this population is unknown. MATERIALS AND METHODS: A total of 690 IS patients aged 15-49 years were included. A 12-lead ECG was obtained 1-14 d after the onset of stroke. We adjusted for demographic factors, comorbidities, and stroke characteristics, Cox regression models were used to identify independent ECG parameters associated with long-term risks of (1) any cardiovascular event, (2) cardiac events, and (3) recurrent stroke...
September 29, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27684209/the-ability-of-an-electrocardiogram-to-predict-fatal-and-non-fatal-cardiac-events-in-asymptomatic-middle-aged-subjects
#20
Henri K Terho, Jani T Tikkanen, Tuomas V Kenttä, M Juhani Junttila, Aapo L Aro, Olli Anttonen, Tuomas Kerola, Harri A Rissanen, Paul Knekt, Antti Reunanen, Heikki V Huikuri
INTRODUCTION: The long-term prognostic value of a standard 12-lead electrocardiogram (ECG) for predicting cardiac events in apparently healthy middle-aged subjects is not well defined. MATERIALS AND METHODS: A total of 9511 middle-aged subjects (mean age 43 ± 8.2 years, 52% males) without a known cardiac disease and with a follow-up 40 years were included in the study. Fatal and non-fatal cardiac events were collected from the national registries. The predictive value of ECG was separately analyzed for 10 and 30 years...
September 29, 2016: Annals of Medicine
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