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Annals of Medicine

Alexandra Migdal, Martin Abrahamson, Anne Peters, Nan Vint
Type 2 Diabetes Mellitus (T2DM) is a growing problem in the United States, affecting 30.3 million Americans, or 9.4% of the US population. Given that T2DM is a progressive disease, intensification of rapid acting insulin (RAI) to address hyperglycemia is often required. The American Diabetes Association and the European Association for the Study of Diabetes recommend individualizing the treatment approach to glucose control, considering factors such as age, health behaviors, comorbidities, and life expectancy...
August 14, 2018: Annals of Medicine
Amirhossein Sahebkar, Luis E Simental-Mendía, Dimitri P Mikhailidis, Matteo Pirro, Maciej Banach, Cesare R Sirtori, Željko Reiner
BACKGROUND: Apolipoprotein C-III (apo C-III) is a key regulator of triglycerides metabolism. The aim of this meta-analysis was to assess the effect of fish omega-3 polyunsaturated fatty acids (PUFAs) on apo C-III levels. METHODS: Randomized placebo-controlled trials investigating the impact of omega-3 on apo C-III levels were searched in PubMed-Medline, SCOPUS, Web of Science and Google Scholar. A random-effects model and generic inverse variance method were used for quantitative data synthesis...
August 13, 2018: Annals of Medicine
Chia-Wen Lu, Yu-Kang Chang, Yi-Hsuan Lee, Chia-Sheng Kuo, Hao-Hsiang Chang, Chi-Ting Huang, Chih-Cheng Hsu, Kuo-Chin Huang
Background Bariatric surgery is associated with a significant improvement in depressive mood in the initial postoperative years, but the maintenance of the improvement is under debate. Aim To explore the association between bariatric surgery and major depressive disorder (MDD) in a 12-year nationwide cohort study. Method Using the National Health Insurance Research Database of Taiwan, we identified 2302 patients who underwent bariatric surgery in 2001-2009. These patients were matched by propensity score to 6493 obese patients who did not receive bariatric surgery...
August 13, 2018: Annals of Medicine
Kadri Haljas, Jari Lahti, Tiinamaija Tuomi, Bo Isomaa, Johan G Eriksson, Leif Groop, Katri Räikkönen
BACKGROUND: The association between depression and type 2 diabetes is bi-directional. Underlying biological determinants remain elusive. We examined if a common Melatonin Receptor 1B gene diabetes risk variant rs10830963 influenced the associations between depressive symptoms and glycemic traits. MATERIALS: The Prevalence, Prediction and Prevention of Diabetes-Botnia Study participants (n = 4555) with no diabetes underwent an oral glucose tolerance test, were genotyped for rs10830963 and completed the Mental Health Inventory on depressive symptoms...
August 8, 2018: Annals of Medicine
Ori Wand, Oshrat E Tayer-Shifman, Shafik Khoury, Alon Y Hershko
INTRODUCTION: There are insufficient data on the aetiologic factors underlying splenic infarction (SI). Therefore, there is no consensus regarding the appropriate diagnostic approach. METHODS: We conducted a retrospective analysis of all patients admitted with SI from January 2004 to December 2014. Medical records were screened for the clinical presentation, underlying causes, associated medical conditions and methods of patient evaluation. RESULTS: We found 89 subjects with 90 episodes of SI...
July 31, 2018: Annals of Medicine
Yolanda González Silva, Laura Abad Manteca, Henar de la Red Gallego, Mónica Álvarez Muñoz, María Luisa Rodríguez Carbajo, Teresa Murcia Casado, Lourdes Ausín Pérez, Jésica Abadía Otero, José-Luis Pérez-Castrillón
OBJECTIVE: To assess the relationship between the FRAX index and the Barthel index/MiniMental State Examination in older people. PATIENTS AND METHODS: Observational descriptive study. Demographic data, comorbidity, dependency and cognitive state, and risk of osteoporotic fracture were collected. RESULTS: 375 patients were included (60% female) Patients with a low-risk FRAX for hip fractures had a higher Mini-mental (25, 95% CI 24 to 27 vs 22, 95% 21 to 23, p = 0...
July 24, 2018: Annals of Medicine
Aki Juhani Käräjämäki, Janne Hukkanen, Olavi Ukkola
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes an enormous burden to human health and health-care systems all over the world. A great proportion of this burden results from increased risk of cardiovascular diseases. Atrial fibrillation (AF) is the most common chronic heart arrhythmia globally and it increases the risk of embolic stroke and heart failure. Recent studies have explored the association between NAFLD and AF with somewhat conflicting results. However, ultrasound-verified prospective studies concur that NAFLD is associated with the incidence of AF...
July 24, 2018: Annals of Medicine
Setor K Kunutsor, Tanjaniina Laukkanen, Jari A Laukkanen
PURPOSE: We sought to determine cross-sectional and longitudinal associations of frequency of sauna bathing with high sensitivity C-reactive protein (hsCRP), fibrinogen, leucocyte count and gamma-glutamyltransferase (GGT). DESIGN: Baseline sauna bathing habits were assessed in 2269 men aged 42-61 years. Concentrations of hsCRP, fibrinogen, leucocyte count, and GGT were determined at baseline and 11 years later. The associations of sauna bathing frequency with baseline and 11-year hsCRP, fibrinogen, leucocyte count, and GGT levels were examined using robust multivariate regression analyses...
July 24, 2018: Annals of Medicine
Hyung Jung Oh, Seulbi Lee, Eun-Kyung Lee, Oesook Lee, Eunhee Ha, Eun-Mi Park, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Seung Jun Kim, Dong-Ryeol Ryu
BACKGROUND: The effects of each blood pressure index [systolic and diastolic blood pressure (SBP, DBP), pulse pressure (PP), mean arterial pressure (MAP)] on the occurrence of mortality and cardiovascular (CV) events have not yet been investigated in prehypertensive populations. METHODS: A total of 30,258 prehypertensive Korean participants underwent periodic health examination between 2003 and 2004 were enrolled, and the associations of BP components with mortality and CV events were investigated...
July 21, 2018: Annals of Medicine
Irene Marafini, Giovanni Monteleone
Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract encompassing two main clinical entities: Crohn's disease (CD) and ulcerative colitis (UC). These disorders are characterized by various grades of tissue damage and development of local complications and extra-intestinal manifestations. The cause of IBD remains unknown but accumulating evidence indicates that both CD and UC arise in genetically predisposed individuals as a result of the action of multiple environmental factors, which ultimately trigger excessive and poorly controlled immune response against antigens of the luminal flora...
July 21, 2018: Annals of Medicine
Hsiu-Li Lin, Hsiu-Chen Lin, Yuan-Fu Tseng, Jane Chen-Jui Chao, Chien-Yeh Hsu
OBJECTIVES: We investigated the association of thiazolidinedione and its dose effect with the risk of Parkinson's disease (PD) in patients with diabetes mellitus (DM). METHODS: This study enrolled 38,521 patients with newly-diagnosed DM, between 2001 and 2013, and compared them to the matched subjects without DM. The hazard ratios (HRs) for PD were compared between the thiazolidinedione-treated and non-thiazolidinedione-treated groups of the study cohort, and between subgroups who received different cumulative dosages of thiazolidinedione...
July 21, 2018: Annals of Medicine
Krista Nuotio, Petra Ijäs, Hanna M Heikkilä, Suvi M Koskinen, Jani Saksi, Pirkka Vikatmaa, Pia Sorto, Laura Mäkitie, Henrietta Eriksson, Sonja Kasari, Heli Silvennoinen, Leena Valanne, Mikko I Mäyränpää, Petri T Kovanen, Lauri Soinne, Perttu J Lindsberg
INTRODUCTION: Every fifth ischemic stroke is caused by thromboembolism originating from an atherosclerotic carotid artery plaque. While prevention is the most cost-effective stroke therapy, antiplatelet and cholesterol-lowering drugs have a ceiling effect in their efficacy. Therefore, discovery of novel pathophysiologic targets are needed to improve the primary and secondary prevention of stroke. This article provides a detailed study design and protocol of HeCES2, an observational prospective cohort study with the objective to investigate the pathophysiology of carotid atherosclerosis...
July 16, 2018: Annals of Medicine
Setor K Kunutsor, Samuel Seidu, Kamlesh Khunti
PURPOSE: Evidence on the association between depression, antidepressant use and venous thromboembolism (VTE) risk is conflicting. We conducted a systematic review and meta-analysis of published observational studies evaluating the associations of depression and antidepressant use with VTE risk. DESIGN: Eligible studies were identified in a literature search of MEDLINE, Embase, Web of Science and reference list of relevant studies up to April 2018. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated aggregated using random effects models...
July 12, 2018: Annals of Medicine
Haoyu Wang, Shuze Wang, Xin Yi, Yining Tao, Hao Qian, Pengyu Jia, Yintao Chen, Yingxian Sun
BACKGROUND: Recently, a novel 4-tiered classification of left ventricular hypertrophy (LVH) based on ventricular dilatation (indexed LV end-diastolic volume [EDV]) and concentricity (mass/EDV0.67 ) has improved all-cause and cardiovascular mortality risk stratification. However, their possible association with ischemic stroke has not been extensively evaluated in the general population. METHODS: We evaluated a cross-sectional study of 11,037 subjects from the general population of China in whom echocardiographic and ischemic stroke data were available to subdivide patients with LVH into four geometric patterns: indeterminate, dilated, thick, and both thick and dilated hypertrophy...
July 12, 2018: Annals of Medicine
Mingjuan Yan, Shaoqun Shu, Chunyuan Guo, Chengyuan Tang, Zheng Dong
Acute kidney injury (AKI) is a medical condition characterized by kidney damage with a rapid decline of renal function, which is associated with high mortality and morbidity. Recent research has further established an intimate relationship between AKI and chronic kidney disease. Perturbations of kidney cells in AKI result in the accumulation of unfolded and misfolded proteins in the endoplasmic reticulum (ER), leading to unfolded protein response (UPR) or ER stress. In this review, we analyze the role and regulation of ER stress in AKI triggered by renal ischemia-reperfusion and cisplatin nephrotoxicity...
July 11, 2018: Annals of Medicine
M Ruscica, N Ferri, C Macchi, A Corsini, C R Sirtori
Inflammatory changes are responsible for maintenance of the atherosclerotic process and may underlie some of the most feared vascular complications. Among the multiple mechanisms of inflammation, the arterial deposition of lipids and particularly of cholesterol crystals is the one responsible for activation of inflammasome NLRP3, followed by the rise of circulating markers, mainly C-reactive protein (CRP). Elevation of lipoproteins, LDL but also VLDL and remnants, associates with increased inflammatory changes and coronary risk...
July 6, 2018: Annals of Medicine
Amirhossein Sahebkar, Luis E Simental-Mendía, Matteo Pirro, Fabrizio Montecucco, Federico Carbone, Maciej Banach, George E Barreto, Alexandra E Butler
AIMS: To assess the effect of fibrates on circulating cystatin C levels. MATERIALS AND METHODS: Clinical studies evaluating the effect of a fibrate on circulating cystatin C levels were searched in PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases. A random-effect model and generic inverse variance method were used for quantitative data synthesis, sensitivity analysis conducted using the leave-one-out method, and weighted random-effects meta-regression performed to evaluate potential confounders on cystatin C levels...
June 29, 2018: Annals of Medicine
Kazuo Miyazawa, Daniele Pastori, Christoph Hammerstingl, Riccardo Cappato, Isabelle Ling Meng, Frank Kramer, Ariel Cohen, Anke Schulz, Martin van Eickels, Gregory Y H Lip, Francisco Marin
BACKGROUND: Non-vitamin K antagonist oral anticoagulants including rivaroxaban are widely used for stroke prevention in patients with atrial fibrillation (AF). We investigated the relationship between plasma biomarkers (indicative of thrombogenesis, fibrinolysis and inflammation) and left atrial thrombus resolution after rivaroxaban treatment. METHODS: This was an ancillary analysis of the X-TRA study, which was a prospective interventional study evaluating the use of rivaroxaban for left atrial/left atrial appendage (LA/LAA) thrombus resolution in AF patients...
June 29, 2018: Annals of Medicine
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June 2018: Annals of Medicine
Leena Äyräväinen, Anna Maria Heikkinen, Antti Kuuliala, Kirsi Ahola, Riitta Koivuniemi, Leena Laasonen, Eeva Moilanen, Mari Hämäläinen, Taina Tervahartiala, Jukka H Meurman, Marjatta Leirisalo-Repo, Timo Sorsa
OBJECTIVE: To study prospectively the association of salivary and serum matrix metalloproteinase (MMP)-8, tissue inhibitor of MMPs (TIMP)-1 and interleukin (IL)-6 with periodontal and systemic inflammation in rheumatoid arthritis (RA). We hypothesized that biomarker concentrations reflect inflammation. METHODS: Fifty three early untreated RA (ERA) and 28 chronic RA (CRA) patients, underwent rheumatological and dental examinations at baseline and one year later after starting first conventional or biological disease modifying antirheumatic drug...
June 2018: Annals of Medicine
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