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Annals of Medicine

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https://www.readbyqxmd.com/read/28537435/comparison-of-treatments-in-patients-with-distal-humerus-intercondylar-fracture-a-systematic-review-and-meta-analysis
#1
Hongwei Chen, Dacheng Li, Jun Zhang, Xinwei Xiong
INTRODUCTION: Distal humerus intercondylar fractures are intra-articular comminuted fractures of the elbow that involve soft tissue injury. We evaluate different surgical approaches and elbow functional outcomes in the treatment of distal humerus fracture. MATERIALS AND METHODS: Medline, Cochrane, EMBASE, Google Scholar databases were searched up to 29 July 2016. All studies had to have evaluated the treatment of patients with intercondylar fractures of the distal humerus...
June 14, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28540743/a-review-on-cardiovascular-effects-of-newer-hypoglycaemic-medications
#2
B Tate Cutshall, Jennifer D Twilla, Andrew S Olinger, Carrie S Oliphant
Cardiovascular disease (CVD) is the most prevalent cause of morbidity and mortality in diabetic patients. Improvement in cardiovascular complications with glycaemic control and managing cardiovascular risk factors is well established. However, the impact of hypoglycaemic medications on CVD is of increasing importance. In 2008, the U.S. Food and Drug Administration issued study regulations for hypoglycaemic agents after rosiglitazone was shown to increase the incidence of myocardial infarction, and the European Medicines Agency provided their own guidance in 2012...
June 9, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28537456/angiogenic-profile-and-smoking-in-the-finnish-genetics-of-pre-eclampsia-consortium-finnpec-cohort
#3
Tiina Jääskeläinen, Sanna Suomalainen-König, Esa Hämäläinen, Kari Pulkki, Jarkko Romppanen, Seppo Heinonen, Hannele Laivuori
OBJECTIVES: The biological mechanism by which smoking reduces the risk of pre-eclampsia (PE) is unresolved. We studied serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and their ratio, in addition to soluble endoglin (sEng) in early and late pregnancy to ascertain whether these factors are altered in women who smoke. SUBJECTS AND METHODS: First trimester serum samples were available from 217 women who later developed PE and 238 women who did not develop PE...
June 9, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28590774/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-in-the-management-of-solitary-pulmonary-nodule-a-review
#4
Duilio Divisi, Mirko Barone, Gino Zaccagna, Roberto Crisci
Solitary pulmonary nodules are common radiologic findings and their detection has increased due to the introduction and improvement of diagnostics. Since a nodule can be an expression of early lung cancers, a proper classification and management are required because its treatment might lead to decreased morbidity and mortality. In this regard, prominent guidelines are available although they are characterized sometimes by discordant and misleading evidences. Furthermore, the same results of studies in the literature appear conflicting...
June 7, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28590772/arterial-stiffness-in-fertile-women-with-metabolic-syndrome
#5
Tiina Vilmi-Kerälä, Teemu Koivistoinen, Outi Palomäki, Jukka Uotila, Ari Palomäki
INTRODUCTION: Although metabolic syndrome (MetS) is evidently associated with the risk of cardiovascular disease (CVD), recently its use has been questioned. We studied the utility of MetS diagnosis when estimating individual CVD risk. METHODS: We compared 27 fertile women with MetS and 27 counterparts without the syndrome, matched pairwise according to well-known risk factors of CVD. Pulse wave velocity (PWV) and central blood pressure (cBP) were determined noninvasively via a SphygmoCor device...
June 7, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28521523/sepsis-in-internal-medicine-wards-current-knowledge-uncertainties-and-new-approaches-for-management-optimization
#6
Vincenzo Zaccone, Alberto Tosoni, Giovanna Passaro, Carla Vincenza Vallone, Michele Impagnatiello, Domenica Donatella Li Puma, Salvatore De Cosmo, Raffaele Landolfi, Antonio Mirijello
Sepsis represents a global health problem in terms of morbidity, mortality, social and economic costs. Although usually managed in Intensive Care Units, sepsis showed an increased prevalence among Internal Medicine wards in the last decade. This is substantially due to the ageing of population and to multi-morbidity. These characteristics represent both a risk factor for sepsis and a relative contra-indication for the admission to Intensive Care Units. Although there is a lack of literature on the management of sepsis in Internal Medicine, the outcome of these patients seems to be gradually improving...
May 27, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28462631/effects-of-selected-dietary-constituents-on-high-sensitivity-c-reactive-protein-levels-in-u-s-adults
#7
Mohsen Mazidi, Andre Pascal Kengne, Dimitri P Mikhailidis, Arrigo F Cicero, Maciej Banach
BACKGROUND AND AIM: Growing evidence suggests that some of the effects of diet on cardiovascular disease (CVD) occur through mechanisms involving subclinical inflammation. We assessed the relationship between selected dietary constituents and serum high-sensitivity C-reactive protein (hsCRP) concentration in a population-based sample of United States adults. METHODS: In this cross-sectional analysis, participants were selected from the US National Health and Nutrition Examination Survey (NHANES) and restricted to those with available data on dietary intake, biochemical and anthropometric measurements from 2001 to 2010...
May 23, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28462603/gluten-related-disorders-certainties-questions-and-doubts
#8
Simona Valenti, Domenico Corica, Luisa Ricciardi, Claudio Romano
In the last decade, the ingestion of gluten, a heterogeneous complex of proteins present in wheat, rice, barley and probably in oats, has been associated with clinical disorders, such as celiac disease, wheat allergy and recently to non-celiac gluten sensitivity or wheat intolerance syndrome. Gluten-related disorders, which are becoming epidemiologically relevant with an estimated global prevalence of about 5%, require the exclusion of gluten from the diet. For the past 5 years, an important shift in the availability of gluten-free products, together with increased consumption in the general population, has been recorded and is estimated to be about 12-25%...
May 11, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28332418/asthma-status-is-an-independent-risk-factor-for-herpes-zoster-in-children-a-population-based-cohort-study
#9
Su-Jing Chen, Kuang-Hua Huang, Wen-Chen Tsai, Cheng-Li Lin, Yih-Dih Cheng, Chang-Ching Wei
BACKGROUNDS: Literatures regarding the effects of childhood asthma on the risk of herpes zoster (HZ) is very limited. The aim of this study is to investigate the risks of children developing HZ with asthma. METHODS: From the National Health Insurance Research Database, we identified 300,649 patients who had asthma between 2000 and 2007 as an asthma cohort. We identified another matched non-asthma cohort. All subjects were followed until the end of 2008. A Cox model was used to estimate the association of asthma on the risk of HZ...
April 23, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28358246/effects-of-direct-renin-inhibition-versus-angiotensin-ii-receptor-blockade-on-angiotensin-profiles-in-non-diabetic-chronic-kidney-disease
#10
Marlies Antlanger, Sebastian Bernhofer, Johannes J Kovarik, Chantal Kopecky, Christopher C Kaltenecker, Oliver Domenig, Marko Poglitsch, Marcus D Säemann
BACKGROUND: Direct renin inhibition (DRI) is clinically inferior to other blockers of the renin-angiotensin system (RAS). Thus far, the underlying molecular causes of this finding remain unknown. METHODS: Twenty four patients with non-diabetic chronic kidney disease (CKD) stages III-IV and albuminuria were randomized to DRI or angiotensin receptor blocker (ARB). Employing a novel mass-spectrometry method, the concentrations of renin, aldosterone and plasma angiotensin peptides [Ang I, Ang II, Ang-(1-7), Ang-(1-5), Ang-(2-8), Ang-(3-8)] were quantified before and after an 8-week treatment...
April 17, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28326854/subclinical-carotid-atherosclerosis-in-patients-with-chronic-obstructive-pulmonary-disease-a-meta-analysis-of-literature-studies
#11
Pasquale Ambrosino, Roberta Lupoli, Giovanni Cafaro, Salvatore Iervolino, Mauro Carone, Nicola Pappone, Matteo Nicola Dario Di Minno
BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients have an increased cardiovascular (CV) morbidity and mortality. Common carotid intima-media thickness (CCA-IMT) and carotid plaques are surrogate markers of subclinical atherosclerosis and predictors of CV events. METHODS AND RESULTS: We performed a meta-analysis to evaluate the association between COPD and subclinical atherosclerosis. Studies evaluating the impact of COPD on CCA-IMT and on the prevalence of carotid plaques were systematically searched...
April 17, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28294644/electrocardiogram-changes-and-atrial-arrhythmias-in-individuals-carrying-sodium-channel-scn5a-d1275n-mutation
#12
Sari U M Vanninen, Kjell Nikus, Katriina Aalto-Setälä
INTRODUCTION: The cardiac sodium channel SCN5A regulates atrioventricular and ventricular depolarization as well as cardiac conduction. Patients with cardiac electrical abnormalities have an increased risk of sudden cardiac death (SCD) and cardio-embolic stroke. Optimal management of cardiac disease includes the understanding of association between the causative mutations and the clinical phenotype. A 12-lead electrocardiogram (ECG) is an easy and inexpensive tool for finding risk patients...
April 17, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28286967/protective-effect-of-glucagon-like-peptide-1-agents-on-reperfusion-injury-for-acute-myocardial-infarction-a-meta-analysis-of-randomized-controlled-trials
#13
Mengjie Huang, Ribao Wei, Yang Wang, Tingyu Su, Qingping Li, Xi Yang, Xiangmei Chen
BACKGROUND: The cardioprotective properties of glucagon-like peptide-1 (GLP-1) receptor agonists in acute myocardial infarction (AMI) patients against reperfusion injury remain unclear. We performed a meta-analysis to assess their role in the acute phase of AMI. METHODS AND RESULTS: Randomized controlled trials (RCTs) comparing GLP-1 agents with placebo in AMI patients undergoing percutaneous coronary intervention were identified by searching PubMed, Embase and Cochrane libraries...
March 31, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28281834/association-of-sleep-disordered-breathing-with-diabetes-associated-kidney-disease
#14
Stefan Stadler, Tanja Zimmermann, Franziska Franke, Myriam Rheinberger, Iris M Heid, Carsten A Böger, Michael Arzt
INTRODUCTION: Diabetes-associated kidney disease is characterized by impairment of renal function and albuminuria. The aim of the present study was to assess whether sleep-disordered breathing is associated with decreased estimated glomerular filtration rate or increased urine-albumin-to-creatinine-ratio independently from known modulators of diabetes-associated kidney disease. MATERIAL AND METHODS: Estimated glomerular filtration rate and urine-albumin-to-creatinine-ratio were determined in the baseline survey of the DIACORE-SDB substudy, a prospectively planned study of Diabetes mellitus 2 patients...
March 27, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28271734/overuse-of-organ-biopsies-in-immunoglobulin-light-chain-amyloidosis-al-the-consequence-of-failure-of-early-recognition
#15
Eli Muchtar, Angela Dispenzieri, Martha Q Lacy, Francis K Buadi, Prashant Kapoor, Suzanne R Hayman, Wilson Gonsalves, Rahma Warsame, Taxiarchis V Kourelis, Rajshekhar Chakraborty, Stephen Russell, John A Lust, Yi Lin, Ronald S Go, Steven Zeldenrust, S Vincent Rajkumar, David Dingli, Nelson Leung, Robert A Kyle, Shaji K Kumar, Morie A Gertz
INTRODUCTION: The diagnosis of amyloidosis requires histological confirmation of Congo-red (CR) deposits. The tissue source is preferably fat aspiration and/or bone marrow (BM) biopsy, but at times organ biopsy is required. METHODS: We studied 612 patients with systemic immunoglobulin light chain amyloidosis to characterise the tissues used to establish the diagnosis. RESULTS: The median number of tissue samples was 3. About 95% of BM biopsies were stained for CR, while 79% of patients had fat aspiration CR-stained...
March 27, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28409656/condomless-sex-and-hiv-transmission-among-serodifferent-couples-current-evidence-and-recommendations
#16
Alan Koff, Carole Goldberg, Onyema Ogbuagu
Human immunodeficiency virus (HIV) infection remains a global pandemic. The primary driver of HIV incidence is sexual transmission between serodifferent individuals. Condoms, when used consistently and correctly, are effective at preventing sexually transmitted HIV infections and are considered an integral component of a comprehensive approach to HIV prevention. However, the demonstrated effectiveness of antiretroviral therapy (ART) to prevent HIV transmission, known as treatment as prevention and of pre-exposure prophylaxis, have raised an intriguing dilemma on the necessity and additive preventive benefit of condom use among individuals in serodifferent relationships utilizing these prevention strategies...
September 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28166422/relation-of-heart-rate-recovery-after-exercise-testing-to-coronary-artery-calcification
#17
Sae Young Jae, Sudhir Kurl, Jari A Laukkanen, Eun Sun Yoon, Yoon-Ho Choi, Bo Fernhall, Barry A Franklin
BACKGROUND: We examined whether slow heart rate recovery (HRR) after exercise testing as an estimate of impaired autonomic function is related to coronary artery calcification (CAC), an emerging marker of coronary atherosclerosis. METHODS: We evaluated 2088 men who participated in a health-screening program that included measures of CAC and peak or symptom-limited cardiopulmonary exercise testing. HRR was calculated as the difference between peak heart rate (HR) during exercise testing and the HR at 2 min of recovery after peak exercise...
August 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28166415/adverse-metabolic-and-mental-health-outcomes-associated-with-shiftwork-in-a-population-based-study-of-277-168-workers-in-uk-biobank
#18
Cathy A Wyse, Carlos A Celis Morales, Nicolas Graham, Yu Fan, Joey Ward, Anne M Curtis, Daniel Mackay, Daniel J Smith, Mark E S Bailey, Stephany Biello, Jason M R Gill, Jill P Pell
BACKGROUND: Reported associations between shiftwork and health have largely been based on occupation-specific, or single sex studies that might not be generalizable to the entire working population. The objective of this study was to investigate whether shiftwork was independently associated with obesity, diabetes, poor sleep, and well-being in a large, UK general population cohort. METHODS: Participants of the UK Biobank study who were employed at the time of assessment were included...
August 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28084122/plasma-endothelin-1-levels-in-patients-with-resistant-hypertension-effects-of-renal-sympathetic-denervation
#19
Luigi Petramala, Federica Olmati, Massimo Mancone, Antonio Concistré, Matteo Galassi, Cristiano Marinelli, Gianfranco Tonnarini, Piernatale Lucia, Umberto Costi, Gino Iannucci, Gennaro Sardella, Claudio Letizia
INTRODUCTION: Resistant arterial hypertension (RHT) is defined as poor controlled blood pressure (BP) despite optimal doses of three or more antihypertensive agents, including a diuretic. In the development of RHT, hyperactivity of sympathetic (SNS) and renin-angiotensin-aldosterone (SRAA) systems are involved, and SNS is a potent stimulator of vasoactive endothelin-1 (ET-1) peptide. Renal sympathetic denervation (RSD) through disrupting renal afferent and efferent nerves attenuates SNS activity...
August 2017: Annals of Medicine
https://www.readbyqxmd.com/read/27813419/anti-interleukin-2-receptor-antibodies-for-the-prevention-of-rejection-in-liver-transplant-recipients-a-systematic-review-and-meta-analysis
#20
Y Zhang, W Jin, X Cai
BACKGROUND: Antibody induction therapy aims at preventing acute cellular rejection by reducing T-cell proliferation and activation. We evaluated the efficacy and side effects of two anti-interleukin-2 receptor antibodies (IL2RAs), basiliximab and daclizumab, for prevention of liver transplant rejection in adult patients. METHODS: Randomized controlled trials (RCTs) on basiliximab or daclizumab were identified by searching multiple databases and reference lists published up to July, 2015...
August 2017: Annals of Medicine
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