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Annals of Medicine

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https://www.readbyqxmd.com/read/28685636/comparisons-of-clinical-impacts-on-individuals-with-brugada-electrocardiographic-patterns-defined-by-ishne-criteria-or-ehra-hrs-aphrs-criteria-a-nationwide-community-based-study
#1
Ching-Yu Julius Chen, Jyh-Ming Jimmy Juang, Ying-Hsiang Chen, I-Chien Wu, Chih-Cheng Hsu, Ray-Chin Wu, Kwo-Ching Chen, Wen-Jin Liaw, Tsung-Lung Tsai, Lian-Yu Lin, Juey-Jen Hwang, Li-Ting Ho, Chih-Chien Yu, Jen-Kuang Lee, Cho-Kai Wu, Shih-Fan Sherri Yeh, Dun-Hui Yang, I-Shou Chang, Ling-Ping Lai, Fu-Tien Chiang, Jiunn-Lee Lin, Chao Agnes Hsiung
INTRODUCTION: Identifying Brugada electrocardiographic pattern (BrP) early is crucial to prevent sudden cardiac death. Two different diagnostic criteria proposed by International Society for Holter and Noninvasive Electrocardiography (ISHNE) and Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society (HRS/EHRA/APHRS) were widely used in clinical practice. The difference in prevalence and prognosis of BrP by applying the two different criteria was never studied before...
July 18, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28657357/ecg-markers-associated-with-ischemic-stroke-at-young-age-a-case-control-study
#2
Jani Pirinen, Antti Eranti, Paul Knekt, Mika Lehto, Nicolas Martinez-Majander, Aapo L Aro, Harri Rissanen, Markku Heliövaara, Markku Kaste, Turgut Tatlisumak, Heikki Huikuri, Jukka Putaala
INTRODUCTION: Certain electrocardiographic (ECG) abnormalities are associated with ischemic stroke (IS), especially cardioembolic subtype. Besides atrial fibrillation, markers of left ventricular hypertrophy (LVH) or atrial pathology also reflect elevated risk. We studied the association of ECG markers with IS in young adults. METHODS: We performed a case-control study including 567 consecutive IS patients aged 15-49 years (inclusion period: 1994-2007) and one or two age- and sex-matched control subjects enrolled during 1978-1980 (n = 1033), and investigated also the stroke aetiologic subgroups...
July 14, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28649865/dental-stem-cells-recent-progresses-in-tissue-engineering-and-regenerative-medicine
#3
João Botelho, Maria Alzira Cavacas, Vanessa Machado, José João Mendes
Since the disclosure of adult mesenchymal stem cells (MSCs) there have been an intense investigation on the characteristics of these cells and their potentialities. Dental Stem Cells (DSCs) are MSC-like populations with self-renewal capacity and multidifferentiation potential. Currently, there are five main DSCs, dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHED), stem cells from apical papilla (SCAP), periodontal ligament stem cells (PDLSCs), and Dental Follicle Precursor Cells (DFPCs)...
June 24, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28590774/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-in-the-management-of-solitary-pulmonary-nodule-a-review
#4
Duilio Divisi, Mirko Barone, Gino Zaccagna, Roberto Crisci
Solitary pulmonary nodules are common radiologic findings and their detection has increased due to the introduction and improvement of diagnostics. Since a nodule can be an expression of early lung cancers, a proper classification and management are required because its treatment might lead to decreased morbidity and mortality. In this regard, prominent guidelines are available although they are characterized sometimes by discordant and misleading evidences. Furthermore, the same results of studies in the literature appear conflicting...
June 23, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28537435/comparison-of-treatments-in-patients-with-distal-humerus-intercondylar-fracture-a-systematic-review-and-meta-analysis
#5
Hongwei Chen, Dacheng Li, Jun Zhang, Xinwei Xiong
INTRODUCTION: Distal humerus intercondylar fractures are intra-articular comminuted fractures of the elbow that involve soft tissue injury. We evaluate different surgical approaches and elbow functional outcomes in the treatment of distal humerus fracture. MATERIALS AND METHODS: Medline, Cochrane, EMBASE, Google Scholar databases were searched up to 29 July 2016. All studies had to have evaluated the treatment of patients with intercondylar fractures of the distal humerus...
June 14, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28540743/a-review-on-cardiovascular-effects-of-newer-hypoglycaemic-medications
#6
B Tate Cutshall, Jennifer D Twilla, Andrew S Olinger, Carrie S Oliphant
Cardiovascular disease (CVD) is the most prevalent cause of morbidity and mortality in diabetic patients. Improvement in cardiovascular complications with glycaemic control and managing cardiovascular risk factors is well established. However, the impact of hypoglycaemic medications on CVD is of increasing importance. In 2008, the U.S. Food and Drug Administration issued study regulations for hypoglycaemic agents after rosiglitazone was shown to increase the incidence of myocardial infarction, and the European Medicines Agency provided their own guidance in 2012...
June 9, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28537456/angiogenic-profile-and-smoking-in-the-finnish-genetics-of-pre-eclampsia-consortium-finnpec-cohort
#7
Tiina Jääskeläinen, Sanna Suomalainen-König, Esa Hämäläinen, Kari Pulkki, Jarkko Romppanen, Seppo Heinonen, Hannele Laivuori
OBJECTIVES: The biological mechanism by which smoking reduces the risk of pre-eclampsia (PE) is unresolved. We studied serum levels of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and their ratio, in addition to soluble endoglin (sEng) in early and late pregnancy to ascertain whether these factors are altered in women who smoke. SUBJECTS AND METHODS: First trimester serum samples were available from 217 women who later developed PE and 238 women who did not develop PE...
June 9, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28590772/arterial-stiffness-in-fertile-women-with-metabolic-syndrome
#8
Tiina Vilmi-Kerälä, Teemu Koivistoinen, Outi Palomäki, Jukka Uotila, Ari Palomäki
INTRODUCTION: Although metabolic syndrome (MetS) is evidently associated with the risk of cardiovascular disease (CVD), recently its use has been questioned. We studied the utility of MetS diagnosis when estimating individual CVD risk. METHODS: We compared 27 fertile women with MetS and 27 counterparts without the syndrome, matched pairwise according to well-known risk factors of CVD. Pulse wave velocity (PWV) and central blood pressure (cBP) were determined noninvasively via a SphygmoCor device...
June 7, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28521523/sepsis-in-internal-medicine-wards-current-knowledge-uncertainties-and-new-approaches-for-management-optimization
#9
Vincenzo Zaccone, Alberto Tosoni, Giovanna Passaro, Carla Vincenza Vallone, Michele Impagnatiello, Domenica Donatella Li Puma, Salvatore De Cosmo, Raffaele Landolfi, Antonio Mirijello
Sepsis represents a global health problem in terms of morbidity, mortality, social and economic costs. Although usually managed in Intensive Care Units, sepsis showed an increased prevalence among Internal Medicine wards in the last decade. This is substantially due to the ageing of population and to multi-morbidity. These characteristics represent both a risk factor for sepsis and a relative contra-indication for the admission to Intensive Care Units. Although there is a lack of literature on the management of sepsis in Internal Medicine, the outcome of these patients seems to be gradually improving...
May 27, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28462631/effects-of-selected-dietary-constituents-on-high-sensitivity-c-reactive-protein-levels-in-u-s-adults
#10
Mohsen Mazidi, Andre Pascal Kengne, Dimitri P Mikhailidis, Arrigo F Cicero, Maciej Banach
BACKGROUND AND AIM: Growing evidence suggests that some of the effects of diet on cardiovascular disease (CVD) occur through mechanisms involving subclinical inflammation. We assessed the relationship between selected dietary constituents and serum high-sensitivity C-reactive protein (hsCRP) concentration in a population-based sample of United States adults. METHODS: In this cross-sectional analysis, participants were selected from the US National Health and Nutrition Examination Survey (NHANES) and restricted to those with available data on dietary intake, biochemical and anthropometric measurements from 2001 to 2010...
May 23, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28462603/gluten-related-disorders-certainties-questions-and-doubts
#11
Simona Valenti, Domenico Corica, Luisa Ricciardi, Claudio Romano
In the last decade, the ingestion of gluten, a heterogeneous complex of proteins present in wheat, rice, barley and probably in oats, has been associated with clinical disorders, such as celiac disease, wheat allergy and recently to non-celiac gluten sensitivity or wheat intolerance syndrome. Gluten-related disorders, which are becoming epidemiologically relevant with an estimated global prevalence of about 5%, require the exclusion of gluten from the diet. For the past 5 years, an important shift in the availability of gluten-free products, together with increased consumption in the general population, has been recorded and is estimated to be about 12-25%...
May 11, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28332418/asthma-status-is-an-independent-risk-factor-for-herpes-zoster-in-children-a-population-based-cohort-study
#12
Su-Jing Chen, Kuang-Hua Huang, Wen-Chen Tsai, Cheng-Li Lin, Yih-Dih Cheng, Chang-Ching Wei
BACKGROUNDS: Literatures regarding the effects of childhood asthma on the risk of herpes zoster (HZ) is very limited. The aim of this study is to investigate the risks of children developing HZ with asthma. METHODS: From the National Health Insurance Research Database, we identified 300,649 patients who had asthma between 2000 and 2007 as an asthma cohort. We identified another matched non-asthma cohort. All subjects were followed until the end of 2008. A Cox model was used to estimate the association of asthma on the risk of HZ...
April 23, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28409656/condomless-sex-and-hiv-transmission-among-serodifferent-couples-current-evidence-and-recommendations
#13
Alan Koff, Carole Goldberg, Onyema Ogbuagu
Human immunodeficiency virus (HIV) infection remains a global pandemic. The primary driver of HIV incidence is sexual transmission between serodifferent individuals. Condoms, when used consistently and correctly, are effective at preventing sexually transmitted HIV infections and are considered an integral component of a comprehensive approach to HIV prevention. However, the demonstrated effectiveness of antiretroviral therapy (ART) to prevent HIV transmission, known as treatment as prevention and of pre-exposure prophylaxis, have raised an intriguing dilemma on the necessity and additive preventive benefit of condom use among individuals in serodifferent relationships utilizing these prevention strategies...
September 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28276869/comorbidities-and-risk-of-mortality-in-patients-with-sleep-apnea
#14
Chi-Lu Chiang, Yung-Tai Chen, Kang-Ling Wang, Vincent Yi-Fong Su, Li-An Wu, Diahn-Warng Perng, Shi-Chuan Chang, Yuh-Min Chen, Tzeng-Ji Chen, Kun-Ta Chou
BACKGROUND: A variety of disorders, most notably cardiovascular diseases, was linked to sleep apnea (SA), but their impact on mortality of SA patients had not been systematically investigated. We aimed to develop a composite index based on the comorbidity burden to predict mortality risk. METHODS: Using Taiwan National Health Insurance Research Database, 9853 adult SA patients were enrolled and their comorbidity profile at baseline was recorded. The subjects were followed from 1995 till death or the end of 2011...
August 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28166422/relation-of-heart-rate-recovery-after-exercise-testing-to-coronary-artery-calcification
#15
Sae Young Jae, Sudhir Kurl, Jari A Laukkanen, Eun Sun Yoon, Yoon-Ho Choi, Bo Fernhall, Barry A Franklin
BACKGROUND: We examined whether slow heart rate recovery (HRR) after exercise testing as an estimate of impaired autonomic function is related to coronary artery calcification (CAC), an emerging marker of coronary atherosclerosis. METHODS: We evaluated 2088 men who participated in a health-screening program that included measures of CAC and peak or symptom-limited cardiopulmonary exercise testing. HRR was calculated as the difference between peak heart rate (HR) during exercise testing and the HR at 2 min of recovery after peak exercise...
August 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28166415/adverse-metabolic-and-mental-health-outcomes-associated-with-shiftwork-in-a-population-based-study-of-277-168-workers-in-uk-biobank
#16
Cathy A Wyse, Carlos A Celis Morales, Nicolas Graham, Yu Fan, Joey Ward, Anne M Curtis, Daniel Mackay, Daniel J Smith, Mark E S Bailey, Stephany Biello, Jason M R Gill, Jill P Pell
BACKGROUND: Reported associations between shiftwork and health have largely been based on occupation-specific, or single sex studies that might not be generalizable to the entire working population. The objective of this study was to investigate whether shiftwork was independently associated with obesity, diabetes, poor sleep, and well-being in a large, UK general population cohort. METHODS: Participants of the UK Biobank study who were employed at the time of assessment were included...
August 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28084122/plasma-endothelin-1-levels-in-patients-with-resistant-hypertension-effects-of-renal-sympathetic-denervation
#17
Luigi Petramala, Federica Olmati, Massimo Mancone, Antonio Concistré, Matteo Galassi, Cristiano Marinelli, Gianfranco Tonnarini, Piernatale Lucia, Umberto Costi, Gino Iannucci, Gennaro Sardella, Claudio Letizia
INTRODUCTION: Resistant arterial hypertension (RHT) is defined as poor controlled blood pressure (BP) despite optimal doses of three or more antihypertensive agents, including a diuretic. In the development of RHT, hyperactivity of sympathetic (SNS) and renin-angiotensin-aldosterone (SRAA) systems are involved, and SNS is a potent stimulator of vasoactive endothelin-1 (ET-1) peptide. Renal sympathetic denervation (RSD) through disrupting renal afferent and efferent nerves attenuates SNS activity...
August 2017: Annals of Medicine
https://www.readbyqxmd.com/read/27813419/anti-interleukin-2-receptor-antibodies-for-the-prevention-of-rejection-in-liver-transplant-recipients-a-systematic-review-and-meta-analysis
#18
Y Zhang, W Jin, X Cai
BACKGROUND: Antibody induction therapy aims at preventing acute cellular rejection by reducing T-cell proliferation and activation. We evaluated the efficacy and side effects of two anti-interleukin-2 receptor antibodies (IL2RAs), basiliximab and daclizumab, for prevention of liver transplant rejection in adult patients. METHODS: Randomized controlled trials (RCTs) on basiliximab or daclizumab were identified by searching multiple databases and reference lists published up to July, 2015...
August 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28084107/the-risk-of-gastrointestinal-bleeding-in-patients-receiving-dabigatran-etexilate-a-systematic-review-and-meta-analysis-of-the-literature
#19
Matteo Nicola Dario Di Minno, Pasquale Ambrosino, Alessandro Di Minno, Elena Tremoli, Giovanni Di Minno
BACKGROUND: Evidence on the risk of gastrointestinal (GI) bleeding associated with dabigatran etexilate (DE) is contrasting. We performed a meta-analysis of literature to address this issue. METHODS AND RESULTS: Studies on GI bleeding risk in patients receiving DE or vitamin-K antagonists (VKA) were systematically searched. Twenty-three studies (26 datasets) showed no difference in the GI bleeding risk between the 250,871 patients treated with DE and the 460,386 receiving VKA (OR: 1...
June 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28042719/insulins-nph-glargine-and-detemir-and-risk-of-severe-hypoglycemia-among-working-age-adults
#20
Arto Y Strandberg, Houssem Khanfir, Sari Mäkimattila, Tero Saukkonen, Timo E Strandberg, Fabian Hoti
INTRODUCTION: The longer acting basal insulin analogs glargine and detemir have shown a lower incidence of hypoglycemia compared to insulin NPH in clinical studies. We evaluated the real-life risk of severe hypoglycemia among new users of insulins in the working-age population in Finland. METHODS: All persons aged 18-65 years with diabetes mellitus who were newly prescribed with insulins NPH, glargine, or detemir during 2006-2009, were identified from national registers...
June 2017: Annals of Medicine
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