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Annals of Internal Medicine

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https://www.readbyqxmd.com/read/28320019/steroid-injections-for-patients-with-low-back-pain
#1
(no author information available yet)
No abstract text is available yet for this article.
March 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28319999/the-challenges-of-research-on-interventions-for-low-back-pain
#2
David J Kennedy, Byron J Schneider
No abstract text is available yet for this article.
March 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28319998/hepatitis-c-down-but-not-out
#3
Jay H Hoofnagle, Averell H Sherker
No abstract text is available yet for this article.
March 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28319997/intradiscal-glucocorticoid-injection-for-patients-with-chronic-low-back-pain-associated-with-active-discopathy-a-randomized-trial
#4
Christelle Nguyen, Isabelle Boutron, Gabriel Baron, Katherine Sanchez, Clémence Palazzo, Raphaël Benchimol, Guillaume Paris, Étienne James-Belin, Marie-Martine Lefèvre-Colau, Johann Beaudreuil, Jean-Denis Laredo, Anne Béra-Louville, Anne Cotten, Jean-Luc Drapé, Antoine Feydy, Philippe Ravaud, François Rannou, Serge Poiraudeau
Background: Active discopathy is associated with a specific phenotype of chronic low back pain (LBP). Local inflammation has a role in active discopathy-associated symptoms. Objective: To assess the efficacy of a single glucocorticoid intradiscal injection (GC IDI) in patients with chronic LBP with active discopathy. Design: Prospective, parallel-group, double-blind, randomized, controlled study. (ClinicalTrials.gov: NCT00804531). Setting: 3 tertiary care centers in France...
March 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28319996/oral-direct-acting-agent-therapy-for-hepatitis-c-virus-infection-a-systematic-review
#5
Oluwaseun Falade-Nwulia, Catalina Suarez-Cuervo, David R Nelson, Michael W Fried, Jodi B Segal, Mark S Sulkowski
Background: Rapid improvements in hepatitis C virus (HCV) therapy have led to the approval of multiple oral direct-acting antiviral (DAA) regimens by the U.S. Food and Drug Administration (FDA) for treatment of chronic HCV infection. Purpose: To summarize published literature on the efficacy and safety of oral DAAs for treatment of persons with chronic HCV infection. Data Sources: MEDLINE and EMBASE from inception through 1 November 2016. Study Selection: 42 English-language studies from controlled and single-group registered clinical trials of adults with HCV infection that evaluated at least 8 weeks of an FDA-approved interferon-free HCV regimen that included at least 2 DAAs...
March 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28319995/clinical-trials-of-therapeutics-for-the-prevention-of-congenital-zika-virus-disease-challenges-and-potential-solutions
#6
Alex P Salam, Amanda Rojek, Jake Dunning, Peter W Horby
Zika virus (ZIKV) infection in pregnancy is associated with adverse fetal outcomes, such as microcephaly and other congenital malformations. No therapeutic options are available to pregnant women with ZIKV infection to prevent these effects. Drug trials in pregnancy raise several scientific, ethical, and logistical challenges, which are compounded further in ZIKV because of limited knowledge of the disease pathophysiology and a product development pipeline in its infancy. We evaluate the major challenges in choosing therapeutics to prevent congenital ZIKV disease and conducting clinical trials of these treatments, with a focus on preventing congenital central nervous system malformations...
March 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28289748/the-cystic-fibrosis-survival-gap-why-do-canadians-fare-better-than-americans
#7
Patrick A Flume, Donald R VanDevanter
No abstract text is available yet for this article.
March 14, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28288488/survival-comparison-of-patients-with-cystic-fibrosis-in-canada-and-the-united-states-a-population-based-cohort-study
#8
Anne L Stephenson, Jenna Sykes, Sanja Stanojevic, Bradley S Quon, Bruce C Marshall, Kristofer Petren, Josh Ostrenga, Aliza K Fink, Alexander Elbert, Christopher H Goss
Background: In 2011, the median age of survival of patients with cystic fibrosis reported in the United States was 36.8 years, compared with 48.5 years in Canada. Direct comparison of survival estimates between national registries is challenging because of inherent differences in methodologies used, data processing techniques, and ascertainment bias. Objective: To use a standardized approach to calculate cystic fibrosis survival estimates and to explore differences between Canada and the United States...
March 14, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28288485/annals-understanding-clinical-research-intention-to-treat-analysis
#9
Joshua M Liao, Catharine B Stack, Michael E Griswold, A Russell Localio
No abstract text is available yet for this article.
March 14, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28288484/pharmacologic-therapy-for-type-2-diabetes-synopsis-of-the-2017-american-diabetes-association-standards-of-medical-care-in-diabetes
#10
James J Chamberlain, William H Herman, Sandra Leal, Andrew S Rhinehart, Jay H Shubrook, Neil Skolnik, Rita Rastogi Kalyani
Description: The American Diabetes Association (ADA) annually updates the Standards of Medical Care in Diabetes to provide clinicians, patients, researchers, payers, and other interested parties with evidence-based recommendations for the diagnosis and management of patients with diabetes. Methods: For the 2017 Standards, the ADA Professional Practice Committee updated previous MEDLINE searches performed from 1 January 2016 to November 2016 to add, clarify, or revise recommendations based on new evidence...
March 14, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265678/cytokine-inhibition-in-patients-with-chronic-fatigue-syndrome-a-randomized-trial
#11
Megan E Roerink, Sebastian J H Bredie, Michael Heijnen, Charles A Dinarello, Hans Knoop, Jos W M Van der Meer
Background: Interleukin-1 (IL-1), an important proinflammatory cytokine, is suspected to play a role in chronic fatigue syndrome (CFS). Objective: To evaluate the effect of subcutaneous anakinra versus placebo on fatigue severity in female patients with CFS. Design: Randomized, placebo-controlled trial from July 2014 to May 2016. Patients, providers, and researchers were blinded to treatment assignment. (ClinicalTrials.gov: NCT02108210). Setting: University hospital in the Netherlands...
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265649/developing-recommendations-for-evidence-based-clinical-preventive-services-for-diverse-populations-methods-of-the-u-s-preventive-services-task-force
#12
Kirsten Bibbins-Domingo, Evelyn Whitlock, Tracy Wolff, Quyen Ngo-Metzger, William R Phillips, Karina W Davidson, Alex H Krist, Jennifer S Lin, Carol M Mangione, Ann E Kurth, Francisco A R García, Susan J Curry, David C Grossman, C Seth Landefeld, John W Epling, Albert L Siu
The U.S. Preventive Services Task Force (USPSTF) summarizes the principles and considerations that guide development of its recommendations for diverse U.S. populations. It uses these principles through each step in the evidence-based guideline process: developing the research plan, conducting the evidence review, developing the recommendation, and communicating to guideline users. Three recent recommendations provide examples of how the USPSTF has used these principles: the 2015 recommendation on screening for abnormal blood glucose and type 2 diabetes; the 2016 recommendation on screening for breast cancer; and the recommendation on screening for prostate cancer, which is currently in progress...
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265644/physicians-patients-and-firearms-the-courts-say-yes
#13
Marian E Betz, Megan L Ranney, Garen J Wintemute
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265642/the-importance-of-international-medical-graduates-in-the-united-states
#14
William W Pinsky
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28241264/annals-understanding-clinical-research-implications-of-missing-data-due-to-dropout
#15
Joshua M Liao, Catharine B Stack
No abstract text is available yet for this article.
February 28, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28241205/human-gene-editing-where-does-the-2017-national-academy-of-sciences-report-bring-us
#16
Jonathan D Moreno
No abstract text is available yet for this article.
February 28, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28241286/internet-delivered-exercise-and-pain-coping-skills-training-for-chronic-knee-pain
#17
(no author information available yet)
No abstract text is available yet for this article.
February 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28241277/improving-symptoms-in-knee-osteoarthritis-can-we-get-there-from-here
#18
Lisa A Mandl
No abstract text is available yet for this article.
February 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28241269/american-health-is-global-health
#19
Khameer K Kidia
No abstract text is available yet for this article.
February 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28241256/single-payer-reform-the-only-way-to-fulfill-the-president-s-pledge-of-more-coverage-better-benefits-and-lower-costs
#20
Steffie Woolhandler, David U Himmelstein
No abstract text is available yet for this article.
February 21, 2017: Annals of Internal Medicine
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