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Anesthesia and Analgesia

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https://www.readbyqxmd.com/read/29341967/new-modalities-for-the-administration-of-inhaled-nitric-oxide-in-intensive-care-units-after-cardiac-surgery-or-for-neonatal-indications-a-prospective-observational-study
#1
Philippe Gaudard, Claudio Barbanti, Bertrand Rozec, Philippe Mauriat, Mimoun M'rini, Gilles Cambonie, Jean Michel Liet, Claude Girard, Pierre Louis Leger, Ziad Assaf, Pierre Damas, Gauthier Loron, Laurent Lecourt, Julien Amour, Philippe Pouard
BACKGROUND: Nitric oxide (NO) has a well-known efficacy in pulmonary hypertension (PH), with wide use for 20 years in many countries. The objective of this study was to describe the current use of NO in real life and the gap with the guidelines. METHODS: This is a multicenter, prospective, observational study on inhaled NO administered through an integrated delivery and monitoring device and indicated for PH according to the market authorizations. The characteristics of NO therapy and ventilation modes were observed...
January 16, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29341966/surveying-the-literature-synopsis-of-recent-key-publications
#2
Eugene A Hessel
No abstract text is available yet for this article.
January 16, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29337731/in-response
#3
Mahesh Nagappa, Thach Lam, Frances Chung
No abstract text is available yet for this article.
January 15, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29337730/effects-of-electrical-transcutaneous-vagus-nerve-stimulation-on-the-perceived-intensity-of-repetitive-painful-heat-stimuli-a-blinded-placebo-and-sham-controlled-randomized-crossover-investigation
#4
Henriette Janner, Catharina Klausenitz, Nancy Gürtler, Klaus Hahnenkamp, Taras I Usichenko
BACKGROUND: Transcutaneous vagus nerve stimulation (TVNS) is a promising treatment for acute and chronic pain. However, experimental studies yielded controversial results. We examined if TVNS reduces the perceived intensity of repetitive painful heat stimulation and temporal summation of pain (TSP) in healthy volunteers in comparison with placebo and sham stimulation, as well as no intervention. METHODS: In 4 sessions, 90 heat pulse stimuli at individual pain tolerance temperature were applied to the ventral forearm of 49 healthy volunteers (25 women) using a Contact Heat Evoked Potential Stimulator thermode (Medoc, Ramat Yishai, Israel)...
January 15, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29337729/evaluation-of-almitrine-infusion-during-veno-venous-extracorporeal-membrane-oxygenation-for-severe-acute-respiratory-distress-syndrome-in-adults
#5
Pierre Esnault, Sami Hraiech, Julien Bordes, Jean-Marie Forel, Mélanie Adda, Romain Rambaud, Samuel Lehingue, Antoine Roch, Laurent Papazian, Christophe Guervilly
This single-center case series investigated the effect of almitrine infusion on PaO2/fraction of inspired oxygen (FIO2) in 25 patients on veno-venous extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. A positive trial was defined as an increase of PaO2/FIO2 ratio ≥20%. Thirty-two trials were performed. Twenty (62.5%, 95% confidence interval, 37.5%-75%) trials in 18 patients were positive, with a median PaO2/FIO2 ratio increase of 35% (25%-43%). A focal acute respiratory distress syndrome and inhaled nitric oxide therapy were more frequent in patients with a positive response to almitrine...
January 15, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29337728/continuous-pulse-oximetry-does-not-measure-blood-pressure
#6
Frank J Overdyk, Suzanne J L Broens
No abstract text is available yet for this article.
January 15, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29337727/ultrasound-in-anesthesia-critical-care-and-pain-management-a-critic-s-review
#7
Kimberly Pollock, Joshua Zimmerman
No abstract text is available yet for this article.
January 15, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29337726/valveless-trocar-systems-and-respiratory-mechanics-need-for-revaluation
#8
Emilie Herrmann, Eric Noll, Girish P Joshi, Pierre A Diemunsch
No abstract text is available yet for this article.
January 15, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29337725/in-response
#9
Claudia Claroni, Marco Covotta, Giulia Torregiani, Ester Forastiere
No abstract text is available yet for this article.
January 15, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29337724/statistical-significance-versus-clinical-importance-of-observed-effect-sizes-what-do-p-values-and-confidence-intervals-really-represent
#10
Patrick Schober, Sebastiaan M Bossers, Lothar A Schwarte
Effect size measures are used to quantify treatment effects or associations between variables. Such measures, of which >70 have been described in the literature, include unstandardized and standardized differences in means, risk differences, risk ratios, odds ratios, or correlations. While null hypothesis significance testing is the predominant approach to statistical inference on effect sizes, results of such tests are often misinterpreted, provide no information on the magnitude of the estimate, and tell us nothing about the clinically importance of an effect...
January 15, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29324503/%C3%AE-asarone-alleviated-chronic-constriction-injury-induced-neuropathic-pain-through-inhibition-of-spinal-endoplasmic-reticulum-stress-in-an-liver-x-receptor-dependent-manner
#11
Yulong Gui, Aiyuan Li, Jie Zhang, Guan Li, Xia Ruan, Qulian Guo, Wangyuan Zou
BACKGROUND: Neuropathic pain is an intractable and complex disease. Recent studies have shown a close relationship between endoplasmic reticulum (ER) stress and neuropathic pain. Here, we investigated the effect of α-asarone, an ER stress inhibitor, on chronic constriction injury (CCI)-induced neuropathic pain. METHODS: Two parts were included in this study. In part 1, rats were assigned to 7 groups: the sham group, the sham + α-asarone 20 mg/kg group, the CCI group, the CCI + vehicle group, the CCI + α-asarone 5 mg/kg group, the CCI + α-asarone 10 mg/kg group, and the CCI + α-asarone 20 mg/kg group...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29324502/in-response
#12
Eva K Kohse, Markus W Hollmann, Jens Kessler
No abstract text is available yet for this article.
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29324501/nonpharmacologic-management-of-acute-singultus-hiccups
#13
Daniel S Orlovich, Jay B Brodsky, John G Brock-Utne
No abstract text is available yet for this article.
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29324500/hydroxyethyl-starch-130-0-4-and-its-impact-on-perioperative-outcome-a-propensity-score-matched-controlled-observation-study
#14
Judith-Irina Pagel, Markus Rehm, Tobias Kammerer, Nikolai Hulde, Eike Speck, Josef Briegel, Falk Reinholz, Alexander Crispin, Klaus F Hofmann-Kiefer
BACKGROUND: Adverse effects of hydroxyethyl starches (HESs) have been verified in patients suffering from sepsis or kidney disease, but not in surgical patients at large. The investigation aimed to determine whether the use of HES 130/0.4 was associated with the incidence of acute postinterventional adverse events compared to Ringer's acetate alone in a perioperative setting. METHODS: This propensity score matched, controlled observational study was performed in a single-centre university hospital...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29324499/adding-to-our-competitive-advantage-making-the-case-for-teaching-communication-and-professionalism
#15
Emily Chanan, Mark D Rollins
No abstract text is available yet for this article.
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29324498/five-steps-to-successfully-implement-and-evaluate-propensity-score-matching-in-clinical-research-studies
#16
Steven J Staffa, David Zurakowski
In clinical research, the gold standard level of evidence is the randomized controlled trial (RCT). The availability of nonrandomized retrospective data is growing; however, a primary concern of analyzing such data is comparability of the treatment groups with respect to confounding variables. Propensity score matching (PSM) aims to equate treatment groups with respect to measured baseline covariates to achieve a comparison with reduced selection bias. It is a valuable statistical methodology that mimics the RCT, and it may create an "apples to apples" comparison while reducing bias due to confounding...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29324497/complications-associated-with-mortality-in-the-national-surgical-quality-improvement-program-database
#17
Robert E Freundlich, Michael D Maile, Joseph J Sferra, Elizabeth S Jewell, Sachin Kheterpal, Milo Engoren
BACKGROUND: Attributing causes of postoperative mortality is challenging, as death may be multifactorial. A better understanding of complications that occur in patients who die is important, as it allows clinicians to focus on the most impactful complications. We sought to determine the postoperative complications with the strongest independent association with 30-day mortality. METHODS: Data were obtained from the 2012-2013 National Surgical Quality Improvement Program Participant Use Data Files...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29324496/efficacy-of-ultrasound-guided-serratus-plane-block-on-postoperative-quality-of-recovery-and-analgesia-after-video-assisted-thoracic-surgery-a-randomized-triple-blind-placebo-controlled-study
#18
Do-Hyeong Kim, Young Jun Oh, Jin Gu Lee, Donghun Ha, Young Jin Chang, Hyun Jeong Kwak
BACKGROUND: The optimal regional technique for analgesia and improved quality of recovery after video-assisted thoracic surgery (a procedure associated with considerable postoperative pain) has not been established. The main objective in this study was to compare quality of recovery in patients undergoing serratus plane block (SPB) with either ropivacaine or normal saline on the first postoperative day. Secondary outcomes were analgesic outcomes, including postoperative pain intensity and opioid consumption...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29324495/intravenously-administered-lidocaine-and-magnesium-during-thyroid-surgery-in-female-patients-for-better-quality-of-recovery-after-anesthesia
#19
Myoung Hwa Kim, Min Soo Kim, Jae Hoon Lee, Sang Tae Kim, Jeong-Rim Lee
BACKGROUND: Although systemic lidocaine and magnesium have been widely studied as perioperative analgesic adjuvants, they have been rarely evaluated with respect to recovery quality under the same conditions. We compared the quality of recovery 40 (QoR-40) scores of female patients who received intravenous lidocaine, magnesium, and saline during thyroidectomy to investigate their effects on comprehensive recovery from anesthesia. METHODS: In this prospective, double-blind trial, 135 female patients scheduled for open thyroidectomy were randomly assigned to the lidocaine group (group L), magnesium group (group M), or control group (group C)...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29324494/myocardial-protection-by-glucose-insulin-potassium-in-moderate-to-high-risk-patients-undergoing-elective-on-pump-cardiac-surgery-a-randomized-controlled-trial
#20
Christoph Ellenberger, Tornike Sologashvili, Lukas Kreienbühl, Mustafa Cikirikcioglu, John Diaper, Marc Licker
BACKGROUND: Low cardiac output syndrome is a main cause of death after cardiac surgery. We sought to assess the impact of glucose-insulin-potassium (GIK) to enhance myocardial protection in moderate- to high-risk patients undergoing on-pump heart surgery. METHODS: A randomized controlled trial was performed in adult patients (Bernstein-Parsonnet score >7) scheduled for elective aortic valve replacement and/or coronary artery bypass surgery. Patients were randomized to GIK (20 IU of insulin, 10 mEq of potassium chloride in 50 mL of glucose 40%) or saline infusion given over 60 minutes on anesthetic induction...
January 9, 2018: Anesthesia and Analgesia
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