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Anesthesia and Analgesia

Francis Veyckemans
No abstract text is available yet for this article.
July 13, 2018: Anesthesia and Analgesia
Matthew D McEvoy, Karl-Christian Thies, Sharon Einav, Kurt Ruetzler, Vivek K Moitra, Mark E Nunnally, Arna Banerjee, Guy Weinberg, Andrea Gabrielli, Gerald A Maccioli, Gregory Dobson, Michael F O'Connor
No abstract text is available yet for this article.
July 13, 2018: Anesthesia and Analgesia
Patrick Schober, Thomas R Vetter
Survival analysis, or more generally, time-to-event analysis, refers to a set of methods for analyzing the length of time until the occurrence of a well-defined end point of interest. A unique feature of survival data is that typically not all patients experience the event (eg, death) by the end of the observation period, so the actual survival times for some patients are unknown. This phenomenon, referred to as censoring, must be accounted for in the analysis to allow for valid inferences. Moreover, survival times are usually skewed, limiting the usefulness of analysis methods that assume a normal data distribution...
July 13, 2018: Anesthesia and Analgesia
Nadir Sharawi, Brendan Carvalho, Ashraf S Habib, Lindsay Blake, Jill M Mhyre, Pervez Sultan
The prevalence of neuraxial opioid-induced clinically significant respiratory depression (CSRD) after cesarean delivery is unknown. We sought to review reported cases of author-reported respiratory depression (ARD) to calculate CSRD prevalence. A 6-database literature search was performed to identify ARD secondary to neuraxial morphine or diamorphine, in parturients undergoing cesarean delivery. "Highest" (definite and probable/possible) and "lowest" (definite) prevalences of CSRD were calculated...
July 11, 2018: Anesthesia and Analgesia
Jacob E Sunshine, Andrew T Humbert, Benjamin Booth, Steven M Bowman, Eileen M Bulger, Sam R Sharar
BACKGROUND: Virtually all anesthesiologists care for patients who sustain traumatic injuries; however, the frequency with which operative anesthesia care is provided to this specific patient population is unclear. We sought to better understand the degree to which anesthesia providers participate in operative trauma care and how this differs by trauma center designation (levels I-V), using data from a comprehensive, regional database-the Washington State Trauma Registry (WSTR). We also sought to specifically assess operative anesthesia care frequency vis a vis the American College of Surgeons guidelines for continuous anesthesiology coverage for Level II trauma center accreditation...
July 11, 2018: Anesthesia and Analgesia
David C Pescod
No abstract text is available yet for this article.
July 11, 2018: Anesthesia and Analgesia
David P Frey, Melissa E Bauer, Carrie L Bell, Lisa Kane Low, Afton L Hassett, Ruth B Cassidy, Katherine D Boyer, Sam R Sharar
This pilot study investigated the use of virtual reality (VR) in laboring women. Twenty-seven women were observed for equivalent time during unmedicated contractions in the first stage of labor both with and without VR (order balanced and randomized). Numeric rating scale scores were collected after both study conditions. Significant decreases in sensory pain -1.5 (95% CI, -0.8 to -2.2), affective pain -2.5 (95% CI, -1.6 to -3.3), cognitive pain -3.1 (95% CI, -2.4 to -3.8), and anxiety -1.5 (95% CI, -0.8 to -2...
July 11, 2018: Anesthesia and Analgesia
Chiao Yen Shih, Chia Ming Chang
No abstract text is available yet for this article.
July 11, 2018: Anesthesia and Analgesia
Bingdong Tao, Kun Liu, Dandan Wang, Yiming Liu, Hong Yin
BACKGROUND: GlideScope video laryngoscope (GS) has been widely used to facilitate tracheal intubation in adults and pediatric patients because it can improve glottic view. Several investigations performed in pediatric patients have shown that GS provides a better view of the glottis than direct laryngoscope (DL). However, to date, there are no studies assessing the use of GS in neonates. Therefore, we conducted a prospective study to compare time to intubate (TTI) when either GS or DL was used for endotracheal intubation in neonates...
July 6, 2018: Anesthesia and Analgesia
Alexandre Joosten, Céline Boudart, Jean-Louis Vincent, Frederic Vanden Eynden, Luc Barvais, Luc Van Obbergh, Joseph Rinehart, Olivier Desebbe
BACKGROUND: Pulse pressure variation (PPV) can be used to predict fluid responsiveness in anesthetized patients receiving controlled mechanical ventilation but usually requires dedicated advanced monitoring. Capstesia (Galenic App, Vitoria-Gasteiz, Spain) is a novel smartphone application that calculates PPV and cardiac output (CO) from a picture of the invasive arterial pressure waveform obtained from any monitor screen. The primary objective was to compare the ability of PPV obtained using the Capstesia (PPVCAP) and PPV obtained using a pulse contour analysis monitor (PPVPC) to predict fluid responsiveness...
July 6, 2018: Anesthesia and Analgesia
Sarah Armour, Trygve K Armour, William R Joppa, Simon Maltais, James A Nelson, Erica Wittwer
Hydroxocobalamin (vitamin B12a) is an emerging treatment for vasoplegic syndrome (VS) associated with cardiopulmonary bypass (CPB). Given its cost and scarcity, an institutional guideline for its use as a rescue treatment in cases of suspected VS was developed. Hemodynamic variables and vasopressor requirements were reviewed for a series of 24 post-CPB patients who received B12a. Favorable changes in hemodynamic parameters and vasopressor requirements were seen after B12a administration although guideline criteria for VS were inconsistently met...
July 2, 2018: Anesthesia and Analgesia
Audra M Webber, Melissa Kreso
No abstract text is available yet for this article.
July 2, 2018: Anesthesia and Analgesia
Michelle H Vu, Guy Weinberg
No abstract text is available yet for this article.
July 2, 2018: Anesthesia and Analgesia
Karam Nam, Younsuk Lee, Hee-Pyoung Park, Jaeyeon Chung, Hyun-Kyu Yoon, Tae Kyong Kim
BACKGROUND: In patients with an unstable cervical spine, maintenance of cervical immobilization during tracheal intubation is important. In McGrath videolaryngoscopic intubation, lifting of the blade to raise the epiglottis is needed to visualize the glottis, but in patients with an unstable cervical spine, this can cause cervical spine movement. By contrast, the Optiscope, a rigid video-stylet, does not require raising of the epiglottis during tracheal intubation. We therefore hypothesized that the Optiscope would produce less cervical spine movement than the McGrath videolaryngoscope during tracheal intubation...
June 28, 2018: Anesthesia and Analgesia
Tatjana S Bevans-Warren, Daniel O Clegg, Derek J Sakata, Christopher A Reilly
No abstract text is available yet for this article.
June 28, 2018: Anesthesia and Analgesia
Oscar Pérez-González, Luis F Cuéllar-Guzmán, Mayra Navarrete-Pacheco, Jorge J Ortiz-Martínez, Wendell H Williams, Juan P Cata
Regional anesthesia may play a beneficial role in long-term oncological outcomes. Specifically, it has been suggested that it can prolong recurrence-free survival and overall survival after gastrointestinal cancer surgery, including gastric and esophageal cancer, by modulating the immune and inflammatory response. However, the results from human studies are conflicting. The goal of this systematic review was to summarize the evidence on the impact of regional anesthesia on immunomodulation and cancer recurrence after gastric and esophageal surgery...
June 28, 2018: Anesthesia and Analgesia
Eva Christensson, Karl A Franklin, Carin Sahlin, Andreas Palm, Jan Ulfberg, Lars I Eriksson, Eva Lindberg, Eva Hagel, Malin Jonsson Fagerlund
BACKGROUND: Obstructive sleep apnea (OSA) is related to postoperative complications and is a common disorder. Most patients with sleep apnea are, however, undiagnosed, and there is a need for simple screening tools. We aimed to investigate whether STOP-Bang and oxygen desaturation index can identify subjects with OSA. METHODS: In this prospective, observational multicenter trial, 449 adult patients referred to a sleep clinic for evaluation of OSA were investigated with ambulatory polygraphy, including pulse oximetry and the STOP-Bang questionnaire in 4 Swedish centers...
June 28, 2018: Anesthesia and Analgesia
Yuen M Cheung, Gail P Scoones, Robert Jan Stolker, Frank Weber
BACKGROUND: The aepEXplus monitoring system, which uses mid-latency auditory evoked potentials to measure depth of hypnosis, was evaluated in pediatric patients receiving desflurane-remifentanil anesthesia. METHODS: Seventy-five patients, 1-18 years of age (stratified for age; 1-3, 3-6, 6-18 years, for subgroup analyses), were included in this prospective observational study. The aepEX and the bispectral index (BIS) were recorded simultaneously, the latter serving as a reference...
June 28, 2018: Anesthesia and Analgesia
Taha Elajnaf, Daniel T Baptista-Hon, Tim G Hales
BACKGROUND: Cardiotoxic effects of local anesthetics (LAs) involve inhibition of NaV1.5 voltage-gated Na channels. Metastatic breast and colon cancer cells also express NaV1.5, predominantly the neonatal splice variant (nNaV1.5) and their inhibition by LAs reduces invasion and migration. It may be advantageous to target cancer cells while sparing cardiac function through selective blockade of nNaV1.5 and/or by preferentially affecting inactivated NaV1.5, which predominate in cancer cells...
June 28, 2018: Anesthesia and Analgesia
Patrick St-Pierre, Issam Tanoubi, Olivier Verdonck, Louis-Philippe Fortier, Philippe Richebé, Isabelle Côté, Christian Loubert, Pierre Drolet
BACKGROUND: We hypothesized that, compared to remifentanil, dexmedetomidine used for endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) performed under monitored anesthesia care (MAC) in nonintubated patients would result in fewer episodes of major respiratory adverse events (number of episodes of bradypnea, apnea or desaturation) but no difference in satisfaction with perioperative conditions. METHODS: Sixty (American Society of Anesthesiologists physical status I-III) patients scheduled to undergo EBUS-TBNA under MAC were randomized to receive either remifentanil (0...
June 28, 2018: Anesthesia and Analgesia
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