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American Journal of Transplantation

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https://www.readbyqxmd.com/read/28326672/bk-polyomavirus-specific-9mer-cd8-t-cell-responses-correlate-with-clearance-of-bk-viremia-in-kidney-transplant-recipients-first-report-from-the-swiss-transplant-cohort-study-stcs
#1
Céline Leboeuf, Sabrina Wilk, Rita Achermann, Isabelle Binet, Dela Golshayan, Karin Hadaya, Cedric Hirzel, Matthias Hoffmann, Uyen Huynh-Do, Michael T Koller, Oriol Manuel, Nicolas J Mueller, Thomas F Mueller, Stefan Schaub, Christian van Delden, Fabian H Weissbach, Hans H Hirsch
BK polyomavirus (BKPyV) causes premature kidney transplant (KT) failure in 1-15% of patients. Since antivirals are lacking, most programs screen for BKPyV-viremia and, if positive, reduce immunosuppression. To evaluate the relationship of viremia and BKPyV-specific immunity, we examined prospectively cryopreserved plasma and PBMCs at T0, T6, and T12 months post-transplant from 28 viremic KT patients and 68 non-viremic controls matched for the transplantation period. BKPyV-IgG seroprevalence was comparable between cases (89...
March 22, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28321984/reciprocity-to-increase-participation-of-compatible-living-donor-and-recipient-pairs-in-kidney-paired-donation
#2
John S Gill, Kathryn Tinckam, Marie Chantal Fortin, Caren Rose, Kara Shick-Makaroff, Kimberly Young, Julie Lesage, Edward H Cole, Maeghan Toews, David N Landsberg, Jagbir Gill
Inclusion of compatible living donor and recipient pairs (CPs) in kidney paired donation (KPD) programs could increase living donor transplantation. We introduce the concept of a reciprocity based strategy in which the recipient of a CP that participates in KPD receives priority for a repeat deceased donor transplant in the event their primary living donor KPD transplant fails, and review the practical and ethical considerations of this strategy. The strategy limits prioritization to CPs already committed to living donation, minimizing the risk of unduly influencing donor behavior...
March 21, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28322021/cytoprotective-and-antioxidant-effects-of-steen-solution-on-human-lung-spheroids-and-human-endothelial-cells
#3
Francesca Pagano, Cristina Nocella, Sebastiano Sciarretta, Luca Fianchini, Camilla Siciliano, Giorgio Mangino, Mohsen Ibrahim, Elena De Falco, Roberto Carnevale, Isotta Chimenti, Giacomo Frati
Respiratory diseases represent a major healthcare burden worldwide. Lung transplantation (LTx) is the gold-standard for end-stage patients, strongly limited by shortage of available/suitable donor lungs. Normothermic ex vivo lung perfusion (EVLP) has significantly increased the number of lungs suitable for transplantation. Steen solution is used for EVLP, but the mechanisms involved in its beneficial properties remain to be clarified. We investigated the effects of Steen solution in an in vitro protocol of cold starvation and normothermic recovery (CS/NR) on human lung spheroids, named pneumospheres (PSs), containing epithelial/basal cells, and on endothelial HUVEC cells...
March 20, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28321975/the-medication-level-variability-index-mlvi-predicts-poor-liver-transplant-outcomes-a-prospective-multi-site-study
#4
Eyal Shemesh, John C Bucuvalas, Ravinder Anand, George V Mazariegos, Estella M Alonso, Robert S Venick, Miguel Reyes-Mugica, Rachel A Annunziato, Benjamin L Shneider
Nonadherence to immunosuppressant medications is a leading cause of poor long-term outcomes in transplant recipients. The Medication Level Variability Index (MLVI) provides a vehicle for transplant outcome risk-stratification through continuous assessment of adherence. The MALT (Medication Adherence in children who had a Liver Transplant) prospective multi-site study evaluated whether MLVI predicts Late Acute Rejection (LAR). 400 pediatric (1-17 year old) liver transplant recipients were enrolled and followed for 2 years...
March 20, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28316132/comment-on-the-article-optn-srtr-2015-annual-data-report-pancreas
#5
LETTER
A C Gruessner
We read with great interest the most recent "OPTN/SRTR 2015 Annual Data Report: Pancreas" (1). We would like to bring to the attention of the editors and authors our serious concerns with respect to flaws in this SRTR report specifically related to pancreas transplantation alone (PTA). First, we noted substantial discrepancies in the number of PTAs (Table PA 1) presented in this article versus the number of PTAs that the International Pancreas Transplant Registry (IPTR) uses for its current analyses. This article is protected by copyright...
March 18, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28316126/hemodialysis-clinic-social-networks-sex-differences-and-renal-transplantation
#6
A Gillespie, E L Fink, H M Traino, A Uversky, S B Bass, J Greener, J Hunt, T Browne, H Hammer, P P Reese, Z Obradovic
This study describes patient social networks within a new hemodialysis clinic and models the association between social network participation and kidney transplantation. Survey and observational data collected between 8/2012 and 2/2015 were used to observe the formation of a social network of 46 hemodialysis patients in a newly opened clinic. Thirty-two (70%) patients formed a social network, discussing health (59%) and transplantation (44%) with other patients. While transplant eligible women participated in the network less often than men (56% vs...
March 18, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28296134/predicting-primary-nonfunction-of-liver-transplants-with-laboratory-values-can-it-be-done
#7
EDITORIAL
Randall S Sung
Determination of primary nonfunction (PNF) of a liver transplant can be one of the most difficult assessments in transplantation. PNF can initially manifest in variety of ways both dramatic and subtle, and no one parameter is sufficient for diagnosis [1,2]. The determination of PNF informs the decision to relist for a second liver transplant. Once relisted, one or more additional confirmations are subsequently necessary in the context of deciding whether to retransplant as donors become available. In addition, a retransplant operation is not without risk, especially in the setting of the existing or impending multiorgan system failure that can be associated with PNF...
March 14, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28295968/nosocomial-bk-polyomavirus-infection-causing-hemorrhagic-cystitis-among-patients-with-hematological-malignancies-after-hematopoietic-stem-cell-transplantation
#8
Jun Kato, Takehiko Mori, Tetsuro Suzuki, Masahiko Ito, Tian-Cheng Li, Masatoshi Sakurai, Yusuke Yamane, Rie Yamazaki, Yuya Koda, Takaaki Toyama, Naoki Hasegwa, Shinichiro Okamoto
BK polyomavirus (BKPyV) is recognized as a pathogen that causes diseases such as hemorrhagic cystitis and nephritis after allogeneic hematopoietic stem cell transplantation (HSCT) or renal transplantation. BKPYV-associated disease is thought to occur through reactivation under immunosuppression. However, the possibility of its nosocomial transmission and the clinical significance of such transmission have not been elucidated. During a 6-month period, 9 adult patients (median age: 47 years) with hematological disorders who were treated with HSCT (N=7) or chemotherapy (N=2) in a single hematology department developed hemorrhagic cystitis due to BKPYV infection...
March 14, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28296181/-white-out-after-lung-transplantation-a-multicentre-cohort-description-of-late-acute-graft-failure
#9
Stijn E Verleden, Jens Gottlieb, Adriana Dubbeldam, Geert M Verleden, Hendrik Suhling, Tobias Welte, Robin Vos, Mark Greer
Graft failure represents a leading cause of mortality following organ transplantation. Acute late-onset graft failure has not been widely reported. This paper describes the demographics, CT imaging pathology findings and treatment of patients presenting with the latter. A retrospective review of lung transplant recipients at 2 large-volume centres was performed. Acute late-onset graft failure was defined as sudden onset of bilateral infiltrates with an oxygenation index <200 without identifiable cause or concurrent extra-pulmonary organ failure...
March 12, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28296155/obituary-of-thomas-e-starzl-m-d-ph-d
#10
EDITORIAL
John J Fung
Thomas E. Starzl was born in LeMars, Iowa, where his father, Roman Starzl, owned and edited the town's newspaper. Young "Tommie" worked at every job on the paper, from printer's devil to reporter. His mother had been a nurse earlier in life. Her encouragement and her long fight with breast cancer inspired Starzl to pursue a medical career. After graduating from high school, he enlisted in the U.S. This article is protected by copyright. All rights reserved.
March 12, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28296000/novel-application-of-localized-nanodelivery-of-anti-il6-protects-organ-transplant-from-ischemia-reperfusion-injuries
#11
Zhabiz Solhjou, Mayuko Uehara, Baharak Bahmani, Omar H Maarouf, Takaharu Ichimura, Craig R Brooks, Wanlong Xu, Mine Yilmaz, Abdala Elkhal, Stefan G Tullius, Indira Guleria, Martina McGrath, Reza Abdi
Ischemia reperfusion injury (IRI) evokes intra-graft inflammatory responses, which markedly augment alloimmune responses against the graft. Understanding the mechanisms underlying these responses is fundamental to develop therapeutic regimens to prevent/ameliorate organ IRI. Here, we demonstrate that IRI results in a marked increase in mitochondrial damage and autophagy in dendritic cells (DC). While autophagy is a survival mechanism for ischemic DC, it also augments their production of IL6. Allograft derived dendritic cells (ADDC) lacking autophagy related gene 5 (Atg5) showed higher death rates post-transplantation...
March 12, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28296255/breg-dependent-islet-transplant-tolerance-is-also-nk-cell-dependent
#12
Christian Schuetz, Kang Mi Lee, Ryan Scott, Lisa Kojima, Laura Washburn, Liye Liu, Wei-Hui Liu, Haley Tector, Ji Lei, Heidi Yeh, James Kim, James F Markmann
Immunologic tolerance to solid organ and islet cell grafts has been achieved in various rodent models using antibodies directed at CD45RB and Tim-1. We have shown that this form of tolerance depends on regulatory B-cells. To elucidate further the mechanism by which Bregs induce tolerance we investigated the requirement of NK and NKT cells in this model. To do so, hyperglycemic B6, μMT, Beige or CD1d(-/-) mice received Balb/c islet grafts and treatment with the tolerance inducing regimen consisting of anti-CD45RB and anti -TIM1...
March 10, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28276660/complement-alternative-pathway-deficiency-in-recipients-protects-kidney-allograft-from-ischemia-reperfusion-injury-and-alloreactive-t-cell-response
#13
Federica Casiraghi, Nadia Azzollini, Marta Todeschini, Sonia Fiori, Regiane Aparecida Cavinato, Paola Cassis, Samantha Solini, Francesca Pezzuto, Marilena Mister, Joshua M Thurman, Ariela Benigni, Giuseppe Remuzzi, Marina Noris
Despite the introduction of novel and more targeted immunosuppressive drugs, the long-term survival of kidney transplants has not improved satisfactorily. Early antigen-independent intra-graft inflammation plays a critical role in the initiation of the alloimmune response and impacts long-term graft function. Complement activation is a key player both in ischemia/reperfusion injury (IRI) as well as in adaptive anti-graft immune response after kidney transplantation. Since the alternative pathway (AP) amplifies complement activation regardless of the initiation pathways and renal IR injured cells undergo uncontrolled complement activation, we wondered whether selective blockade of AP could be a strategy for prolonging kidney graft survival...
March 9, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28276658/safety-and-outcomes-in-100-consecutive-donation-after-circulatory-death-liver-transplants-using-a-protocol-that-includes-thrombolytic-therapy
#14
H Bohorquez, J B Seal, A J Cohen, A Kressel, E Bugeaud, D S Bruce, I C Carmody, T W Reichman, N Battula, M Alsaggaf, G Therapondos, N Bzowej, G Tyson, S Joshi, R Nicolau-Raducu, N Girgrah, G E Loss
Donation after circulatory death (DCD) liver transplantation (LT) reportedly yields inferior survival and increased complication rates compared with donation after brain death (DBD). We compare 100 consecutive DCD LT using a protocol that includes thrombolytic therapy (late DCD group) to an historical DCD group (early DCD group n=38) and a cohort of DBD LT recipients (DBD group n=435). Late DCD LT recipients had better 1 and 3 year graft survival rates than early DCD LT recipients (92% vs. 76.3%, p=0.03 and 91...
March 9, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28276629/improved-fetal-hemoglobin-with-mtor-inhibitor-based-immunosuppression-in-a-kidney-transplant-recipient-with-sickle-cell-disease
#15
Noémie Gaudre, Pierre Cougoul, Pablo Bartolucci, Gaëlle Dörr, Alessandra Bura-Riviere, Nassim Kamar, Arnaud Del Bello
Fetal hemoglobin induction is a key-point in the management of sickle-cell disease (SCD). Herein, we report on a kidney-transplant recipient with SCD that was treated with everolimus, a mammalian target of rapamycin inhibitor. At 10 months after initiating therapy, HbF level was dramatically increased (from 4.8% to 15%) and there was excellent tolerance to treatment. This article is protected by copyright. All rights reserved.
March 9, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28267898/laparoscopic-biopsies-in-pancreas-transplantation
#16
P D Uva, J S Odorico, A Giunippero, I C Cabrera, A Gallo, L R Leon, E Minue, F Toniolo, I Gonzalez, E Chuluyan, D H Casadei
As there is no precise laboratory test or imaging study for detection of pancreas allograft rejection, there is increasing interest in obtaining pancreas tissue for diagnosis. Pancreas allograft biopsies are most commonly performed percutaneously, transcystoscopically, or endoscopically, yet pancreas transplant surgeons often lack the skills to perform these types of biopsies. We have performed 160 laparoscopic pancreas biopsies in 95 patients. There were 146 simultaneous kidney-pancreas biopsies and 14 pancreas only biopsies due to pancreas alone, kidney loss or extraperitoneal kidney...
March 7, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28267897/outcomes-of-pediatric-kidney-transplantation-in-recipients-of-a-previous-non-renal-solid-organ-transplant
#17
Gilad Hamdani, Bin Zhang, Chunyan Liu, Jens Goebel, Yue Zhang, Edward Nehus
Children who receive a non-renal solid organ transplant may develop secondary renal failure requiring kidney transplantation. We investigated outcomes of 165 pediatric kidney transplant recipients who previously received a heart, lung, or liver transplant using data from 1988-2012 reported to the United Network for Organ Sharing. Patient and allograft survival were compared with 330 matched primary kidney transplant (PKT) recipients. Kidney transplantation after solid organ transplant (KASOT) recipients experienced similar allograft survival: 5 and 10-year graft survival was 78% and 60% in KASOT recipients, compared to 80% and 61% in PKT recipients (p=0...
March 7, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28257169/filtration-markers-cardiovascular-disease-mortality-and-kidney-outcomes-in-stable-kidney-transplant-recipients-the-favorit-trial
#18
M C Foster, D E Weiner, A G Bostom, M A Carpenter, L A Inker, P Jarolim, A A Joseph, J W Kusek, T Pesavento, M A Pfeffer, M Rao, S D Solomon, A S Levey
Cystatin C and beta-2-microglobulin (B2M) are filtration markers associated with adverse outcomes in non-transplant populations, sometimes with stronger associations than for creatinine. We evaluated associations of estimated glomerular filtration rate from cystatin C (eGFRcys ), B2M (eGFRB2M ), and creatinine (eGFRcr ) with cardiovascular outcomes, mortality, and kidney failure in stable kidney transplant recipients using a case-cohort study nested within the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) Trial...
March 3, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28251829/radiological-analysis-of-unused-donor-lungs-a-tool-to-improve-donor-acceptance-for-transplantation
#19
Stijn E Verleden, An Martens, Sofie Ordies, Tobias Heigl, Hannelore Bellon, Elly Vandermeulen, Anke Van Herck, Annelore Sacreas, Johny Verschakelen, Walter Coudyzer, Dirk E Van Raemdonck, Robin Vos, Birgit Weynand, Geert M Verleden, Bart Vanaudenaerde, Arne Neyrinck
Despite donor organ shortage, a large proportion of possible donor lungs are declined for transplantation. Criteria for accepting/declining lungs remain controversial since there are not much adequate tools to aid in decision-making. We collected, air-inflated and froze a large series of declined/unused donor lungs and subjected these lung specimens to CT examination. Affected target regions were scanned using microCT. Lungs from 28 donors were collected. Two lungs were unused, 6 were declined for non-allograft-related reasons (collectively denominated non-allograft declines, n=8), while 20 were declined because of allograft-related reasons...
March 1, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28251816/inferior-outcomes-on-the-waiting-list-in-low-volume-pediatric-heart-transplant-centers
#20
Abbas Rana, Charles D Fraser, Brandi B Scully, Jeffrey S Heinle, E Dean McKenzie, William J Dreyer, Michael Kueht, Hao Liu, Eileen D Brewer, Todd K Rosengart, Christine A O'Mahony, John A Goss
Low case volume has been associated with poor outcomes in a wide spectrum of procedures. Our objective is to study the association of low case volume and worse outcomes in pediatric heart transplant centers, taking the novel approach of including waitlist outcomes in the analysis. We studied a cohort of 6,482 candidates listed in the Organ Procurement and Transplantation Network for pediatric heart transplantation between 2002 and 2014; 4,665 of the candidates (72%) were transplanted. Candidates were divided into groups according to the average annual transplant volume performed in the listing center during the study period: > 10, 6-10, 3-5, and <3...
March 1, 2017: American Journal of Transplantation
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