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American Journal of Surgical Pathology

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https://www.readbyqxmd.com/read/28922187/novel-histologic-finding-adipose-tissue-is-prevalent-within-penile-tunica-albuginea-and-corpora-cavernosa-an-anatomic-study-of-63-specimens-and-considerations-for-cancer-invasion
#1
Ingrid M Rodriguez, Martin Cuevas, Arturo Silvero, Sofía Cañete-Portillo, Diego F Sanchez, Jose Barreto, Antonio L Cubilla
Adipose tissue, along with arteries, veins, and peripheral nerves, is a normal constituent of mesenchymal tissues encasing the corpora cavernosa at the level of the penile shaft, variously designated as penile fascia or Bucks fascia. To our knowledge, the presence of fat has not been previously reported within the corpora cavernosa. One or 2 transversal histologic sections at the level of the surgical margin at the shaft of 63 consecutive partial penectomy specimens for squamous cell carcinoma were evaluated...
September 15, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28914717/the-relationship-between-mismatch-repair-deficiency-and-pd-l1-expression-in-breast-carcinoma
#2
Anne M Mills, Erik A Dill, Christopher A Moskaluk, Jaroslaw Dziegielewski, Tim N Bullock, Patrick M Dillon
Mismatch repair (MMR) deficiency in solid tumors has recently been linked to susceptibility to immunotherapies targeting the programmed cell death-1 (PD-1)/programmed cell death-1 ligand (PD-L1) axis. Loss of MMR proteins has been shown to correlate with tumoral PD-L1 expression in colorectal and endometrial carcinomas, but the association between expression of MMR proteins and PD-L1 has not previously been studied in breast carcinoma, where MMR deficiency is less common. We assessed the relationship between PD-L1 and MMR protein expression by immunohistochemistry in 245 primary and 40 metastatic breast carcinomas...
September 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28914716/diagnostic-utility-of-satb2-in-metastatic-krukenberg-tumors-of-the-ovary-an-immunohistochemical-study-of-70-cases-with-comparison-to-cdx2-ck7-ck20-chromogranin-and-synaptophysin
#3
Chen Yang, Li Sun, Lingxin Zhang, Lixin Zhou, Ming Zhao, Yan Peng, Dongfeng Niu, Zhongwu Li, Xiaozheng Huang, Qiang Kang, Lin Jia, Jinping Lai, Dengfeng Cao
SATB2 is a sensitive marker for colorectal adenocarcinomas. No study has investigated its diagnostic utility in metastatic Krukenberg tumors (MKTs) of the ovary. Here we performed immunohistochemical staining SATB2 in 70 MKTs of various origins (stomach 27, colorectum 13, appendix 20 including 19 metastatic adenocarcinomas ex goblet cell carcinoids [AdexGCC] and 1 conventional poorly differentiated carcinoma with signet ring cells, breast 5, bladder 3, lung 2) to assess its diagnostic utility. We also compared SATB2 with CDX2, CK7, CK20, chromogranin, and synaptophysin in MKTs of gastric origin (MKTs-stomach), those of colorectal origin (MKTs-colorectum) and those due to appendiceal AdexGCCs (MKT-AdexGCCs) for their sensitivity and specificity to distinguish these tumors...
September 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28914715/diffuse-staining-for-activated-notch1-correlates-with-notch1-mutation-status-and-is-associated-with-worse-outcome-in-adenoid-cystic-carcinoma
#4
Dipti P Sajed, William C Faquin, Chris Carey, Eric A Severson, Amir H Afrogheh, Carl A Johnson, Stephen C Blacklow, Nicole G Chau, Derrick T Lin, Jeffrey F Krane, Vickie Y Jo, Joaquín J Garcia, Lynette M Sholl, Jon C Aster
NOTCH1 is frequently mutated in adenoid cystic carcinoma (ACC). To test the idea that immunohistochemical (IHC) staining can identify ACCs with NOTCH1 mutations, we performed IHC for activated NOTCH1 (NICD1) in 197 cases diagnosed as ACC from 173 patients. NICD1 staining was positive in 194 cases (98%) in 2 major patterns: subset positivity, which correlated with tubular/cribriform histology; and diffuse positivity, which correlated with a solid histology. To determine the relationship between NICD1 staining and NOTCH1 mutational status, targeted exome sequencing data were obtained on 14 diffusely NICD1-positive ACC specimens from 11 patients and 15 subset NICD1-positive ACC specimens from 15 patients...
September 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28914714/radiologically-undetected-hepatocellular-carcinoma-in-patients-undergoing-liver-transplantation-an-immunohistochemical-correlation-with-li-rads-score
#5
Wei Xiong, Gregory Cheeney, Sooah Kim, Violetta Kolesnikova, Brooke Henninger, Jacob Alexander, Paul E Swanson, Melissa P Upton, Camtu D Truong, Matthew M Yeh
Orthotopic liver transplantation is the best option for patients with carefully selected unresectable disease because of underlying liver dysfunction. The 5-year survival rate after orthotopic liver transplantation for early detected hepatocellular carcinoma (HCC) is high, and a similar or even higher rate is reported in those with radiologically undetected HCC. This study evaluated and compared the histologic features of pretransplant radiologically undetected (14 patients, 25 tumors) versus detected (36 patients, 45 tumors) HCCs...
September 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877067/diagnostic-and-prognostic-biomarkers-of-adrenal-cortical-carcinoma
#6
Ozgur Mete, Hasan Gucer, Mehmet Kefeli, Sylvia L Asa
The diagnosis of low-grade adrenal cortical carcinoma (ACC) confined to the adrenal gland can be challenging. Although there are diagnostic and prognostic molecular tests for ACC, they remain largely unutilized. We examined the diagnostic and prognostic value of altered reticulin framework and the immunoprofile of biomarkers including IGF-2, proteins involved in cell proliferation and mitotic spindle regulation (Ki67, p53, BUB1B, HURP, NEK2), DNA damage repair (PBK, γ-H2AX), telomere regulation (DAX, ATRX), wnt-signaling pathway (beta-catenin) and PI3K signaling pathway (PTEN, phospho-mTOR) in a tissue microarray of 50 adenomas and 43 carcinomas that were characterized for angioinvasion as defined by strict criteria, Weiss score, and mitotic rate-based tumor grade...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877066/clinicopathologic-and-molecular-characteristics-of-synchronous-colorectal-carcinoma-with-mismatch-repair-deficiency
#7
Kayoko Nakano, Hidetaka Yamamoto, Minako Fujiwara, Yutaka Koga, Shinichi Tsuruta, Eikichi Ihara, Eiji Oki, Masafumi Nakamura, Yoshihiro Ogawa, Yoshinao Oda
Synchronous colorectal carcinoma (CRC) is a unique disease associated with a high prevalence (∼35%) of microsatellite instability and occasionally with Lynch syndrome. The clinicopathologic and molecular features of synchronous CRC are poorly understood, particularly in Japanese patients. We examined 118 Japanese patients (236 tumors) with synchronous CRC and 117 Japanese patients (117 tumors) with solitary CRC with immunohistochemical staining for TP53 and mismatch repair (MMR) protein (MLH1, MSH2, PMS2, and MSH6) and mutation analyses of KRAS and BRAF genes...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877065/hpv-related-multiphenotypic-sinonasal-carcinoma-an-expanded-series-of-49-cases-of-the-tumor-formerly-known-as-hpv-related-carcinoma-with-adenoid-cystic-carcinoma-like-features
#8
Justin A Bishop, Simon Andreasen, Jen-Fan Hang, Martin J Bullock, Tiffany Y Chen, Alessandro Franchi, Joaquin J Garcia, Douglas R Gnepp, Carmen R Gomez-Fernandez, Stephan Ihrler, Ying-Ju Kuo, James S Lewis, Kelly R Magliocca, Stefan Pambuccian, Ann Sandison, Emmanuelle Uro-Coste, Edward Stelow, Katalin Kiss, William H Westra
Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related carcinoma with adenoid cystic carcinoma-like features, is a peculiar neoplasm that is restricted to the sinonasal tract, exhibits features of both a surface-derived and salivary gland carcinoma (particularly adenoid cystic carcinoma), and is associated with high-risk HPV. Given the limited number of published cases, the full clinicopathologic spectrum of this neoplasm is unclear. Here, we present an updated experience of 49 cases...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877064/desmoplastic-pattern-at-the-tumor-front-defines-poor-prognosis-subtypes-of-colorectal-cancer
#9
Hideki Ueno, Yukihide Kanemitsu, Shigeki Sekine, Megumi Ishiguro, Eisaku Ito, Yojiro Hashiguchi, Fukuo Kondo, Hideyuki Shimazaki, Satsuki Mochizuki, Yoshiki Kajiwara, Eiji Shinto, Junji Yamamoto
Although recent findings of cancer biology research indicate that prognostic power arises from genes expressed by stromal cells rather than epithelial cells, desmoplastic reaction (DR) has not been completely examined as a prognostic marker for colorectal cancer. A pathologic review of 821 stage II and III patients who underwent R0 resection for colorectal cancer at 4 independent institutions was conducted. DR was classified as mature, intermediate, or immature based on the existence of hyalinized keloid-like collagen and myxoid stroma at the extramural desmoplastic front...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877063/sentinel-lymph-nodes-in-classic-invasive-lobular-carcinoma-of-the-breast-cytokeratin-immunostain-ensures-detection-and-precise-determination-of-extent-of-involvement
#10
Ami Patel, Timothy D'Alfonso, Esther Cheng, Syed A Hoda
The assessment of sentinel lymph nodes (SLN) on hematoxylin and eosin (H&E)-stained sections in cases of classic type of invasive lobular carcinoma (cILC) is considered unreliable, particularly in cases with minimal involvement, that is by either isolated tumor cells (pN0i+) or micrometastases (pN1mi). Although the impact of minimal SLN involvement has been shown to be insignificant in most clinical trials (even though cILC was either under-represented or not separated in the respective cohorts), the results of MIRROR trial did emphasize the need for additional therapy in cases with minimally involved SLN to ensure improved disease-free survival...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877062/recurrent-braf-gene-fusions-in-a-subset-of-pediatric-spindle-cell-sarcomas-expanding-the-genetic-spectrum-of-tumors-with-overlapping-features-with-infantile-fibrosarcoma
#11
Yu-Chien Kao, Christopher D M Fletcher, Rita Alaggio, Leonard Wexler, Lei Zhang, Yun-Shao Sung, Dicle Orhan, Wei-Chin Chang, David Swanson, Brendan C Dickson, Cristina R Antonescu
Infantile fibrosarcomas (IFS) represent a distinct group of soft tissue tumors occurring in patients under 2 years of age and most commonly involving the extremities. Most IFS show recurrent ETV6-NTRK3 gene fusions, sensitivity to chemotherapy, and an overall favorable clinical outcome. However, outside these well-defined pathologic features, no studies have investigated IFS lacking ETV6-NTRK3 fusions, or tumors with the morphology resembling IFS in older children. This study was triggered by the identification of a novel SEPT7-BRAF fusion in an unclassified retroperitoneal spindle cell sarcoma in a 16-year-old female by targeted RNA sequencing...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877061/maml2-rearrangements-in-variant-forms-of-mucoepidermoid-carcinoma-ancillary-diagnostic-testing-for-the-ciliated-and-warthin-like-variants
#12
Justin A Bishop, Morgan L Cowan, Chung H Shum, William H Westra
Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Recent studies have shown that most MECs harbor gene fusions involving MAML2-an alteration that appears to be specific for MEC, a finding that could be diagnostically useful. While most cases of MEC are histologically straightforward, uncommon variants can cause considerable diagnostic difficulty. We present 2 variants of MEC for which MAML2 studies were crucial in establishing a diagnosis: a previously undescribed ciliated variant, and the recently described Warthin-like variant...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877060/clinicopathologic-diversity-of-undifferentiated-sarcoma-with-bcor-ccnb3-fusion-analysis-of-11-cases-with-a-reappraisal-of-the-utility-of-immunohistochemistry-for-bcor-and-ccnb3
#13
Atsuji Matsuyama, Eisuke Shiba, Yoshihisa Umekita, Kanae Nosaka, Takihiro Kamio, Hiroyuki Yanai, Chika Miyasaka, Reiko Watanabe, Ichiro Ito, Tomoko Tamaki, Shinichi Hayashi, Masanori Hisaoka
Undifferentiated sarcoma harboring the BCOR-CCNB3 fusion is characterized by its predilection to affect skeletons of adolescent males, cellular small round/spindle cell morphology, and CCNB3 immunoreactivity. We analyzed 11 cases of BCOR-CCNB3 sarcoma, 10 of which were identified in a reverse transcription-polymerase chain reaction-based screen of 85 patient samples recorded in our database as unclassified small round or spindle cell sarcomas. BCOR rearrangements were confirmed by fluorescence in situ hybridization in 8 tumors...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877059/choriocarcinoma-in-women-analysis-of-a-case-series-with-genotyping
#14
Johanna Savage, Emily Adams, Emanuela Veras, Kathleen M Murphy, Brigitte M Ronnett
Choriocarcinoma is an uncommon malignant neoplasm, which can be either gestational or nongestational in origin. Distinction of these subtypes has prognostic and therapeutic implications. Twenty-two tumors were genotyped using polymerase chain reaction amplification of 15 short tandem repeat loci and the amelogenin locus (XY determination). DNA patterns from tumor and maternal tissue, as well as villous tissue from any available prior or concurrent gestation, were compared, to determine gestational versus nongestational nature (containing vs...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877058/nonuniform-distribution-of-high-risk-human-papillomavirus-in-squamous-cell-carcinomas-of-the-oropharynx-rethinking-the-anatomic-boundaries-of-oral-and-oropharyngeal-carcinoma-from-an-oncologic-hpv-perspective
#15
Elise Gelwan, Ian-James Malm, Armen Khararjian, Carol Fakhry, Justin A Bishop, William H Westra
The oral cavity and oropharynx have historically been viewed as a single anatomic compartment of the head and neck. The practice of combining the oral cavity and oropharynx has recently been revised, largely owing to the observation that human papillomavirus (HPV)-related carcinogenesis has a strong predilection for the oropharynx but not the oral cavity. The purpose of this study was to determine whether HPV is evenly distributed across squamous cell carcinomas of the oropharynx including those sites that do not harbor tonsillar tissues such as the soft palate...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877057/pleuroparenchymal-fibroelastosis-a-review-of-histopathologic-features-and-the-relationship-between-histologic-parameters-and-survival
#16
Reena Khiroya, Claudio Macaluso, Maria A Montero, Athol U Wells, Felix Chua, Maria Kokosi, Toby M Maher, Anand Devaraj, Alexandra Rice, Elisabetta A Renzoni, Andrew G Nicholson
Pleuroparenchymal fibroelastosis (PPFE) is now a defined clinicopathologic entity in the updated 2013 ATS/ERS classification of idiopathic interstitial pneumonias (IIPs), which has led to a significant increase in cases being diagnosed at our institution. We have therefore reviewed 43 PPFE cases (58 biopsies in total) to assess whether any clinical or histopathologic features provide prognostic information. A semiquantatitive grading system was used to assess extent of fibroblastic foci, intra-alveolar fibroelastosis, visceral pleural fibrosis, chronic inflammation in areas of fibrosis, vascular fibrointimal thickening, and presence of granulomas...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877056/pax8-expression-in-a-subset-of-malignant-peritoneal-mesotheliomas-and-benign-mesothelium-has-diagnostic-implications-in-the-differential-diagnosis-of-ovarian-serous-carcinoma
#17
David B Chapel, Aliya N Husain, Thomas Krausz, Stephanie M McGregor
Distinguishing malignant peritoneal mesothelioma (MPM) from serous carcinoma involving the peritoneum remains a diagnostic challenge, particularly in small biopsy and cytology specimens. In this distinction, PAX8 expression has been regarded as a specific marker of serous carcinoma. In addition, BAP1 loss is reportedly specific to MPM, in the distinction from both benign mesothelial lesions and ovarian serous tumors (OSTs). Using immunohistochemistry, we examined PAX8 and BAP1 expression in 27 MPMs, 25 cases of benign mesothelium, and 45 OSTs...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877055/solitary-fibrous-tumors-of-the-head-and-neck-a-multi-institutional-clinicopathologic-study
#18
Steven C Smith, William E Gooding, Matthew Elkins, Rajiv M Patel, Paul W Harms, Andrew S McDaniel, Nallasivam Palanisamy, Cora Uram-Tuculescu, Bonnie B Balzer, David R Lucas, Raja R Seethala, Jonathan B McHugh
Solitary fibrous tumors (SFTs) of the head and neck are uncommon. Lesions previously diagnosed in the head and neck as hemangiopericytomas (HPCs), giant cell angiofibromas (GCAs), and orbital fibrous histiocytomas (OFHs) are now recognized as within the expanded spectrum of SFTs. To better understand the clinicopathologic profile of head and neck SFTs, we performed a multi-institutional study of 88 examples. There was no sex predilection (F:M ratio 1.2), and the median patient age was 52 years (range: 15 to above 89 y)...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877054/melanotic-translocation-renal-cell-carcinoma-with-a-novel-arid1b-tfe3-gene-fusion
#19
Tatjana Antic, Jerome B Taxy, Mir Alikhan, Jeremy Segal
A 36-year-old male was found to have a 7.0 cm left upper pole renal mass on renal ultrasound. Following nephrectomy, the mass was grossly ill-demarcated, friable and red-brown, invading renal parenchyma, hilar fat and the renal vein. Microscopically, the tumor had a nested and papillary architecture. The cells demonstrated abundant clear and eosinophilic cytoplasm and focal intracytoplasmic melanin pigment. Nucleoli were prominent. By immunohistochemistry, the tumor was positive for TFE3; HMB-45 stained approximately 5% of tumor cells corresponding to the histologic melanin pigment, which was confirmed with Fontana-Masson stain with bleach...
September 4, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28877053/-atypical-pleomorphic-lipomatous-tumor-a-clinicopathologic-immunohistochemical-and-molecular-study-of-21-cases-emphasizing-its-relationship-to-atypical-spindle-cell-lipomatous-tumor-and-suggesting-a-morphologic-spectrum-atypical-spindle-cell-pleomorphic-lipomatous
#20
David Creytens, Thomas Mentzel, Liesbeth Ferdinande, Evelyne Lecoutere, Joost van Gorp, Lilit Atanesyan, Karel de Groot, Suvi Savola, Nadine Van Roy, Jo Van Dorpe, Uta Flucke
The classification of the until recently poorly explored group of atypical adipocytic neoplasms with spindle cell features, for which recently the term atypical spindle cell lipomatous tumor (ASLT) has been proposed, remains challenging. Recent studies have proposed ASLT as a unique entity with (in at least a significant subset of cases) a specific genetic background, namely deletions/losses of 13q14, including RB1 and its flanking genes RCBTB2, DLEU1, and ITM2B. Similar genetic aberrations have been reported in pleomorphic liposarcomas (PLSs)...
September 4, 2017: American Journal of Surgical Pathology
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