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American Journal of Surgical Pathology

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https://www.readbyqxmd.com/read/29762142/cytology-preparations-of-formalin-fixative-aid-detection-of-giardia-in-duodenal-biopsy-samples-a-helpful-tool-for-diagnosing-esophageal-candidiasis-as-well
#1
Sören Schröder, Thomas Günther
No abstract text is available yet for this article.
May 14, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29762141/pd-1-expression-in-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-cll-sll-and-large-b-cell-richter-transformation-dlbcl-rt-a-characteristic-feature-of-dlbcl-rt-and-potential-surrogate-marker-for-clonal-relatedness
#2
Rong He, Wei Ding, David S Viswanatha, Dong Chen, Min Shi, Daniel Van Dyke, Shulan Tian, Linda N Dao, Sameer A Parikh, Tait D Shanafelt, Timothy G Call, Stephen M Ansell, Jose F Leis, Ming Mai, Curtis A Hanson, Karen L Rech
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a low-grade B-cell neoplasm and ∼2% to 9% patients develop an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (Richter transformation, DLBCL-RT). Programmed death-1 (PD-1) pathway plays a crucial role in tumor host immunity evasion and its blockade has emerged as an effective anti-cancer immunotherapy. PD-L1 and PD-1 expression has shown predictive value in anti-PD cancer immunotherapy; however, it has not been well documented in CLL/SLL and DLBCL-RT...
May 14, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29750666/pd-l1-immunohistochemistry-assay-concordance-in-urothelial-carcinoma-of-the-bladder-and-hypopharyngeal-squamous-cell-carcinoma
#3
Anjelica Hodgson, Elzbieta Slodkowska, Achim Jungbluth, Stanley K Liu, Danny Vesprini, Danny Enepekides, Kevin Higgins, Nora Katabi, Bin Xu, Michelle R Downes
Programmed death ligand-1 (PD-L1) immunohistochemistry is used to guide treatment decisions regarding the use of checkpoint immunotherapy in the management of urothelial carcinoma of the bladder and hypopharyngeal (HP) squamous cell carcinoma. With increasing PD-L1 testing options, a need has arisen to assess the analytical comparability of diagnostic assays in order to develop a more sustainable testing strategy. Using tissue microarrays, PD-L1 expression in tumor cells (TCs) and immune cells (ICs) was manually scored in 197 cases and 27 cases of bladder and HP cancer, respectively...
May 10, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29738361/intraductal-papillary-mucinous-neoplasms-of-minor-salivary-glands-with-akt1-p-glu17lys-mutation
#4
Abbas Agaimy, Sarina K Mueller, Klaus Bumm, Heinrich Iro, Evgeny A Moskalev, Arndt Hartmann, Robert Stoehr, Florian Haller
The spectrum of low-grade intraductal papillary proliferations of the salivary glands is heterogenous, and reproducible morphologic diagnostic criteria have not yet been established. Recognized types are sialadenoma papilliferum, inverted ductal papilloma, and intraductal papilloma, but some lesions have been possibly included in the morphologic spectrum of cystadenoma or low-grade intraductal carcinomas. We herein present detailed morphologic, immunophenotypic, and genotypic features of 3 minor salivary gland neoplasms affecting 2 men (aged 65 and 71 y) and 1 woman (aged 78 y)...
May 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29738360/intraobserver-and-interobserver-variability-in-the-assessment-of-dysplasia-in-ampullary-mucosal-biopsies
#5
Felicia D Allard, Jeffrey D Goldsmith, Gamze Ayata, Tracy L Challies, Robert M Najarian, Imad A Nasser, Helen Wang, Eric U Yee
Endoscopic mucosal biopsies of the ampulla of Vater (AmpBx) are obtained to histologically assess for dysplasia or carcinoma. However, biopsy material is often scant and a host of factors can induce histologic changes that pose diagnostic challenges. We sought to investigate observer variability in interpretation of AmpBx and the impact clinical data may have on diagnostic interpretation. Thirty-one cases from institutional archives were selected, including 12 cases of reactive atypia (RA), 8 indefinite for dysplasia (ID), and 11 showing low-grade dysplasia (LGD)...
May 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29738359/genomic-profile-and-pathologic-features-of-diffuse-large-b-cell-lymphoma-subtype-of-methotrexate-associated-lymphoproliferative-disorder-in-rheumatoid-arthritis-patients
#6
Joaquim Carreras, Yara Yukie Kikuti, Masashi Miyaoka, Shinichiro Hiraiwa, Sakura Tomita, Haruka Ikoma, Yusuke Kondo, Sawako Shiraiwa, Kiyoshi Ando, Shinji Sato, Yasuo Suzuki, Ikuo Miura, Giovanna Roncador, Naoya Nakamura
Rheumatoid arthritis patients often develop the diffuse large B-cell lymphoma subtype of methotrexate-associated lymphoproliferative disorder (DLBCLMTX-LPD ). We characterized the genomic profile and pathologic characteristics of 20 biopsies using an integrative approach. DLBCLMTX-LPD was associated with extranodal involvement, a high/high-intermediate international prognostic index in 53% of cases, and responded to MTX withdrawal. The phenotype was nongerminal center B-cell in 85% of samples and Epstein-Barr encoding region positive (EBER+ ) in 65%, with a high proliferation index and intermediate MYC expression levels...
May 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29738364/a-newly-recognized-histologic-pattern-of-igg4-related-lymphadenopathy-expanding-the-morphologic-spectrum
#7
Ying-Ren Chen, Yi-Ju Chen, Ming-Chung Wang, L Jeffrey Medeiros, Kung-Chao Chang
Immunoglobulin (Ig)G4-related sclerosing disease is a fibroinflammatory disorder characterized by tumor-forming lesions at multiple anatomic sites and by increased serum levels of IgG4. IgG4-related lymphadenopathy, defined as lymphadenopathy developing in patients with IgG4-related sclerosing disease, is known to manifest in 5 histologic patterns: (1) multicentric Castleman disease-like; (2) reactive follicular hyperplasia; (3) interfollicular plasmacytosis with immunoblasts; (4) progressive transformation of germinal centers-like; and (5) inflammatory pseudotumor-like...
May 4, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29738363/pancreatic-lipomatous-hamartoma-a-hitherto-unrecognized-variant
#8
Mariko Tanaka, Tetsuo Ushiku, Masako Ikemura, Yutaka Takazawa, Toru Igari, Michio Shimizu, Hiroshi Yamaguchi, Noriyoshi Fukushima, Kei Sakuma, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Takeyuki Watadani, Yousuke Nakai, Kazuhiko Koike, Masashi Fukayama
Pancreatic masses consisting of lipomatous components clinically include lipoma, liposarcoma, lipomatous pseudohypertrophy of the pancreas, fat-containing neoplasms such as perivascular epithelioid cell tumor, and malignant neoplasm with lipoid degeneration. We present pancreatic lipomatous hamartoma, which has not been reported hitherto. A solid pancreatic mass was detected from a computed tomographic scan check-up in each of 3 cases of Japanese men. Macroscopically, well-demarcated solid lipomatous masses were detected at the uncus, body, and tail of the pancreas, respectively...
May 4, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29738362/colonic-adenomatous-polyps-involving-submucosal-lymphoglandular-complexes-a-diagnostic-pitfall
#9
Hee Eun Lee, Tsung-Teh Wu, Vishal S Chandan, Michael S Torbenson, Taofic Mounajjed
Lymphoglandular complexes (LGCs) are lymphoid nodules containing intestinal mucosa, present in close apposition to muscularis mucosae or submucosa. Rarely, colorectal adenomas involve submucosal LGCs, simulating invasive adenocarcinoma with associated submucosal lymphoid aggregates, and presenting a diagnostic pitfall. We aimed to identify distinctive histologic features between submucosal LGCs and true invasion. Seven adenomas (tubular/tubulovillous adenomas [n=6], including 4 with high-grade dysplasia and 1 with focal intramucosal adenocarcinoma, and sessile serrated adenoma [n=1]) were in the right (n=5) and left colon (n=2)...
May 4, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29697438/improved-progression-prediction-in-barrett-s-esophagus-with-low-grade-dysplasia-using-specific-histologic-criteria
#10
Fiebo J C Ten Kate, Daan Nieboer, Fiebo J W Ten Kate, Michail Doukas, Marco J Bruno, Manon C W Spaander, Leendert H J Looijenga, Katharina Biermann
Risk stratification of patients with Barrett's esophagus (BE) is based on diagnosis of low-grade dysplasia (LGD). LGD has a poor interobserver agreement and a limited value for prediction of progression to high-grade dysplasia or esophageal adenocarcinoma. Specific reproducible histologic criteria may improve the predictive value of LGD. Four gastrointestinal pathologists examined 12 histologic criteria associated with LGD in 84 BE patients with LGD (15 progressors and 69 nonprogressors). The criteria with at least a moderate (kappa, 0...
April 24, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29697437/routine-use-of-adjunctive-p16-immunohistochemistry-improves-diagnostic-agreement-of-cervical-biopsy-interpretation-results-from-the-certain-study
#11
Mark H Stoler, Thomas C Wright, Alex Ferenczy, James Ranger-Moore, Qijun Fang, Monesh Kapadia, Ruediger Ridder
The diagnosis of squamous intraepithelial lesions in cervical tissue specimens is subject to substantial variability. Adjunctive immunohistochemical (IHC) staining for p16 has been shown to add objective biomarker information to morphologic interpretation of hematoxylin and eosin (H&E)-stained tissues. In the CERvical Tissue AdjunctIve aNalysis (CERTAIN) study, we systematically analyzed the impact of adjunctive p16 IHC on the accuracy (agreement with reference pathology results) of diagnosing cervical intraepithelial neoplasia of grade 2 or worse (CIN2+) in the United States...
April 24, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29683821/urothelial-carcinoma-in-situ-of-the-bladder-with-glandular-differentiation-report-of-92-cases
#12
Zhiming Yang, Jonathan I Epstein
Urothelial carcinoma in situ (CIS) of the bladder with glandular differentiation (CIS-GL) is rare with some showing an association with small cell carcinoma. There is a paucity of data on whether CIS-GL diagnosed in the absence of invasive carcinoma is associated with an increased risk of developing small cell carcinoma of the bladder. Twenty-seven cases of CIS-GL were identified from the consult files of one of the authors from 2008 to 2015 without prior or coexisting invasive carcinoma at the time of diagnosis...
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29683820/gastric-type-endocervical-adenocarcinoma-involving-the-endometrium-and-clinically-mimicking-endometrial-neoplasia-a-diagnostic-challenge
#13
Aurelia Busca, Jelena Mirkovic, Carlos Parra-Herran
No abstract text is available yet for this article.
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29683819/primary-and-metastatic-melanoma-with-ntrk-fusions
#14
Cecilia Lezcano, Alexander N Shoushtari, Charlotte Ariyan, Travis J Hollmann, Klaus J Busam
A number of oncogenic driver mutations have been identified in melanocytic nevi and melanoma, but translocations also play a role in tumorigenesis and provide potential therapeutic targets for malignant lesions. Various translocations, such as those involving the anaplastic lymphoma kinase (ALK), neurotrophic tropomyosin receptor kinase 1 (NTRK1), and NTRK3 have been reported in spitzoid melanocytic neoplasms leading to kinase-fusion proteins that result in immunohistochemically detectable ALK or NTRK expression...
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29683818/pan-trk-immunohistochemistry-identifies-ntrk-rearrangements-in-pediatric-mesenchymal-tumors
#15
Erin R Rudzinski, Christina M Lockwood, Bradley A Stohr, Sara O Vargas, Rachel Sheridan, Jennifer O Black, Veena Rajaram, Theodore W Laetsch, Jessica L Davis
Activating neurotrophic receptor kinase (NTRK) fusions define certain pediatric mesenchymal tumors, including infantile fibrosarcoma and cellular mesoblastic nephroma. Traditionally, molecular confirmation of these fusions has included either fluorescent in situ hybridization for ETV6 rearrangements or reverse-transcriptase polymerase chain reaction for the classic ETV6-NTRK3 fusion. However, these methods overlook variant NTRK rearrangements, which are increasingly appreciated as recurrent events in a subset of pediatric mesenchymal tumors...
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29683817/the-etv6-ret-gene-fusion-is-found-in-etv6-rearranged-low-grade-sinonasal-adenocarcinoma-without-ntrk3-involvement
#16
Simon Andreasen, Katalin Kiss, Linea C Melchior, Jan Laco
No abstract text is available yet for this article.
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29683816/immunohistochemical-detection-and-molecular-characterization-of-idh-mutant-sinonasal-undifferentiated-carcinomas
#17
Jeffrey K Mito, Justin A Bishop, Peter M Sadow, Edward B Stelow, William C Faquin, Stacey E Mills, Jeffrey F Krane, Christopher A French, Christopher D M Fletcher, Jason L Hornick, Lynette M Sholl, Vickie Y Jo
Recent studies have identified recurrent isocitrate dehydrogenase 2 (IDH2) mutations in a subset of sinonasal undifferentiated carcinomas (SNUCs); however, the true frequency of IDH mutations in SNUC is unknown. We evaluated the utility of mutation-specific IDH1/2 immunohistochemistry (IHC) in a large multi-institutional cohort of SNUC and morphologic mimics. IHC using a multispecific antibody for IDH1/2 (R132/R172) mutant protein was performed on 193 sinonasal tumors including: 53 SNUCs, 8 poorly differentiated carcinomas (PDCARs) and 132 histologic mimics...
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29683815/salivary-secretory-carcinoma-with-a-novel-etv6-met-fusion-expanding-the-molecular-spectrum-of-a-recently-described-entity
#18
Lisa M Rooper, Theodoros Karantanos, Yi Ning, Justin A Bishop, Sarah W Gordon, Hyunseok Kang
Secretory carcinoma of the salivary glands, also known as mammary analogue secretory carcinoma, is a recently described tumor characterized by generally indolent clinical behavior and recurrent ETV6-NTRK3 fusions. However, a small subset of recent cases with high-grade histology, aggressive behavior, or alternate molecular findings are expanding the spectrum of this entity. In this case, a 59-year-old female presented with an infiltrative submandibular gland tumor that was originally classified as a high-grade acinic cell carcinoma, papillary-cystic variant...
April 20, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29668487/are-sporadic-eosinophilic-solid-and-cystic-renal-cell-carcinomas-characterized-by-somatic-tuberous-sclerosis-gene-mutations
#19
Megan Parilla, Sabah Kadri, Sushant A Patil, Lauren Ritterhouse, Jeremy Segal, Kammi J Henriksen, Tatjana Antic
Eosinophilic solid and cystic renal cell carcinomas (ESC RCC) is a rare, unique tumor type not yet included in the World Health Organization classification of renal neoplasia. Separately, RCCs found in patients with tuberous sclerosis complex (TSC) have recently been categorized into 3 morphologic groups: RCC with a tubulopapillary architecture separated by smooth muscle stroma, chromophobe-like, and eosinophilic-microcytic type. The third classification has been identified in ∼11% of TSC-associated RCC and have histology identical to ESC RCCs...
April 17, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29664741/primary-vaginal-gastric-type-adenocarcinoma-and-vaginal-adenosis-exhibiting-gastric-differentiation-report-of-a-series-with-detailed-immunohistochemical-analysis
#20
Richard Wing-Cheuk Wong, Michelle Moore, Karen L Talia, Raji Ganesan, W Glenn McCluggage
So-called gastric-type adenocarcinoma and related premalignant lesions have been characterized in the cervix, but similar lesions are not widely recognized in the vagina. We report a series of 11 vaginal glandular lesions exhibiting gastric differentiation, comprising 5 cases of adenocarcinoma and 6 of adenosis. All cases occurred in adults (aged 33 to 69) with no known history of diethylstilboestrol exposure. The vaginal adenocarcinomas exhibited morphologic features identical to gastric-type adenocarcinoma of the cervix, but 1 case additionally demonstrated basaloid and sarcomatoid components, which have not been previously reported in cervical gastric-type adenocarcinoma...
April 16, 2018: American Journal of Surgical Pathology
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