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American Journal of Surgical Pathology

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https://www.readbyqxmd.com/read/30418186/papillary-adenomas-and-other-small-epithelial-tumors-in-the-kidney-an-autopsy-study
#1
Anna Caliò, Kathleen A Warfel, John N Eble
The aim of this work was to study small neoplasms of the epithelium of the renal tubules; kidneys from 402 unselected autopsies were sectioned at 1 to 2 mm intervals. All lesions were examined histologically. A total of 232 papillary adenomas were found in 76 patients (19%), ranging from 1 to 35 adenomas/patient (mean: 3, median: 2). Patients with papillary adenomas were older (range: 27 to 90 y) (P<0.0001), more commonly smokers (P=0.01), and more frequently had glomerulosclerosis (P=0.0001) than those without...
November 9, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30418185/-fat-rich-spindle-cell-poor-variants-of-atypical-spindle-cell-lipomatous-tumors-show-similar-morphologic-immunohistochemical-and-molecular-features-as-dysplastic-lipomas-are-they-related-lesions
#2
Michael Michal, Abbas Agaimy, Alejandro L Contreras, Michal Michal, John F Fetsch
No abstract text is available yet for this article.
November 9, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30418184/the-spectrum-of-ebv-positive-mucocutaneous-ulcer-a-study-of-9-cases
#3
Lucía Prieto-Torres, Itziar Eraña, Rocio Gil-Redondo, Inés Gómez de la Riva, Rebeca Manso, Raquel Pajares, Raúl Córdoba, Salma Machan, Mariano Ara, Luís Requena, Miguel Á Piris, Socorro M Rodríguez-Pinilla
We describe a series of 9 patients with Epstein-Barr virus (EBV)-positive mucocutaneous lymphoproliferative lesions that broadens the concept of EBV-positive mucocutaneous ulcer. We report 5 female and 4 male patients, with an average age of 74 years (range, 55 to 87 y), 2 of whom were HIV-positive. The lesions were located in the oropharynx, skin, and rectal and/or genital mucosa. Histopathologically, 6 cases showed a polymorphic pattern and 3 had a monomorphic and diffuse one, with angiotropism in 4 cases (2 each with the polymorphic and monomorphic patterns)...
November 9, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30407212/clinicopathologic-features-of-cic-nutm1-sarcomas-a-new-molecular-variant-of-the-family-of-cic-fused-sarcomas
#4
François Le Loarer, Daniel Pissaloux, Sarah Watson, Catherine Godfraind, Louise Galmiche-Rolland, Karen Silva, Laetitia Mayeur, Antoine Italiano, Audrey Michot, Gaëlle Pierron, Alexandre Vasiljevic, Dominique Ranchère-Vince, Jean Michel Coindre, Franck Tirode
CIC-fused sarcomas represent an emerging family of tumors, for long connected to the Ewing family group of tumors, but underlined by distinct CIC fusions with different partners. 3' Fusion partners include DUX4, FOXO4, and, as recently emphasized, NUTM1. In this study, we report the clinicopathologic and molecular features of a series of 6 CIC-NUTM1 sarcomas. Mean age at diagnosis was 6 years (2 to 27 y), and 4 patients were male individuals. Primary tumors were located in the central nervous system (n=3), paravertebral soft tissue and epidural spaces (n=1, each), and lung (n=1)...
November 6, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30379651/hypothalamic-vasopressin-producing-tumors-often-inappropriate-diuresis-but-occasionally-cushing-disease
#5
Sylvia L Asa, Shereen Ezzat, Daniel F Kelly, Pejman Cohan, Yuki Takasumi, Garni Barkhoudarian, Anthony P Heaney, Rowena Ridout, Constance L Chik, Lester D R Thompson, Fred Gentili, Ozgur Mete
Tumors of hypothalamic neurons that produce vasopressin are rare. We retrieved all cases of vasopressin-positive tumors in the sellar region from the database of the Department of Pathology. Five cases fulfilled the selection criteria, representing the first series of such tumors. Clinical, radiologic, and pathologic features were reviewed. Four tumors classified as neurocytomas were identified in 3 females and 1 male patient; the ages at onset of symptoms ranged from 17 to 40 years. All were large sellar masses with suprasellar extension and/or invasion of the parasellar sinuses...
October 30, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30379650/spindle-and-round-cell-sarcoma-with-ewsr1-patz1-gene-fusion-a-sarcoma-with-polyphenotypic-differentiation
#6
Abhijit Chougule, Martin S Taylor, Valentina Nardi, Ivan Chebib, Gregory M Cote, Edwin Choy, G Petur Nielsen, Vikram Deshpande
The evolving classification of round cell sarcomas is driven by molecular alterations. EWSR1-PATZ1 fusion positive spindle and round cell sarcoma is one such new tumor entity. Herein, we report 2 EWSR1-PATZ1 fusion positive spindle and round cell sarcomas with overlapping histologic features and polyphenotypic differentiation. The intra-abdominal tumors affected female patients, 31-and 53-year old. Both tumors showed sheets and nests of round to spindle cells, fine chromatin, tiny conspicuous nucleoli, moderate cytoplasm, and thick bands of intratumoral fibrosis...
October 30, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30371510/tenosynovitis-with-psammomatous-calcifications-a-distinctive-trauma-associated-subtype-of-idiopathic-calcifying-tenosynovitis-with-a-predilection-for-the-distal-extremities-of-middle-aged-women-a-report-of-23-cases
#7
Michael Michal, Abbas Agaimy, Andrew L Folpe, Iva Zambo, Radek Kebrle, Raymund E Horch, Zdenek Kinkor, Marian Svajdler, Tomas Vanecek, Filip Heidenreich, Dmitry V Kazakov, Kvetoslava Michalova, Ladislav Hadravsky, Michal Michal
The term "idiopathic calcifying tenosynovitis" (ICT) refers to a clinically and radiologically defined syndrome of pain and tendinous calcifications, most often involving the shoulder joint. A distinctive subset of ICT cases, termed "tenosynovitis with psammomatous calcifications" (TPC), occurs in the distal extremities and shows characteristic morphology, in particular psammomatous calcifications. As only 14 cases have been reported to date, TPC remains poorly recognized by both pathologists and clinicians...
October 26, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30371509/utility-of-combined-ezh2-p-erk1-2-p-stat-and-myc-expression-in-the-differential-diagnosis-of-ezh2-positive-hodgkin-lymphomas-and-related-large-b-cell-lymphomas
#8
Xuejun Tian, Jie Xu, David M Dorfman
EZH2 is a methyltransferase that plays an important tumorigenic role in various neoplasms. We previously found that EZH2 is expressed in a range of aggressive B-cell lymphomas (ABCLs), T-cell lymphomas, and histiocytic neoplasms, with differential expression of intracellular signaling molecules p-ERK, MYC, and p-STAT3, potential regulators of EZH2 expression. We studied EZH2 expression in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), classic Hodgkin lymphoma (cHL), T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL), and B-cell Lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphomas and classic Hodgkin lymphoma (BCLu-DLBCL/cHL), as well as the coexpression of p-ERK, MYC, and p-STAT3 in these neoplasms...
October 26, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30346305/mycobacterium-chimaera-hepatitis-a-new-disease-entity
#9
Nafis Shafizadeh, Gillian Hale, Julu Bhatnagar, Najeeb S Alshak, Jim Nomura
Mycobacterium chimaera was identified as a species within the Mycobacterium avium complex in 2004. Until recently, it was predominantly seen in immunocompromised patients. In 2015, an outbreak of disseminated M. chimaera disease was described in European patients after undergoing open-heart surgery in which contaminated heater-cooler water units were used. Using whole genomic sequencing and phylogenetic analysis, investigators found a highly clonal outbreak from the German manufacturing site of the heater-cooler water units...
October 22, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30334831/tumor-budding-and-prognosis-in-gastric-adenocarcinoma
#10
Niko Kemi, Maarit Eskuri, Julia Ikäläinen, Tuomo J Karttunen, Joonas H Kauppila
Tumor budding has been associated with poor prognosis in several cancer types, but its significance in gastric cancer is unknown. The aim of this study was to assess the prognostic significance of tumor budding in gastric adenocarcinoma, and its main histologic types. Some 583 gastric adenocarcinoma patients who underwent surgery in Oulu University Hospital during the years 1983-2016 were included in this retrospective cohort study. Tumor budding was counted per 0.785 mm fields from the slides originally used for diagnostic purposes...
October 16, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30334830/epstein-barr-virus-associated-pulmonary-carcinoma-proposing-an-alternative-term-and-expanding-the-histologic-spectrum-of-lymphoepithelioma-like-carcinoma-of-the-lung
#11
Yi-Chen Yeh, Hua-Lin Kao, Kang-Lung Lee, Mei-Han Wu, Hsiang-Ling Ho, Teh-Ying Chou
Lymphoepithelioma-like carcinoma (LELC) of the lung is a rare Epstein-Barr virus (EBV)-associated carcinoma. It is histologically characterized by a syncytial growth pattern with marked lymphocytic infiltration that is indistinguishable from the histology observed in undifferentiated nasopharyngeal carcinomas. However, it has been noted that LELC can display nonclassic morphology and lack significant lymphocytic infiltration. In this study, we conducted a comprehensive clinicopathologic analysis of 61 patients with pulmonary LELC and performed automatic quantification of the lymphocytic infiltrate using the IHC Profiler software...
October 16, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30334829/clinical-insignficance-of-monoclonal-t-cell-populations-and-duodenal-intraepithelial-t-cell-phenotypes-in-celiac-and-nonceliac-patients
#12
Romulo Celli, Pei Hui, Hannah Triscott, Sidney Bogardus, Joanna Gibson, Michael Hwang, Marie E Robert
Refractory celiac disease (RCD) is a rare condition, usually managed at specialized centers. However, gastroenterologists and pathologists in general practices are often the first to consider a diagnosis of RCD in celiac patients with persistent symptoms. The distinction between type I and type II RCD is crucial as patients with RCD II have a shortened life expectancy. The diagnosis of RCD II requires the demonstration of abnormal intraepithelial lymphocytes and/or monoclonal T-cell populations in duodenal biopsies, typically assessed in formalin-fixed paraffin-embedded tissue...
October 16, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30334828/cutaneous-leishmaniasis-contribution-of-routine-histopathology-in-unexpected-encounters
#13
Jerome B Taxy, Harry M Goldin, Sara Dickie, Thomas Cibull
The ulcerated papules of cutaneous leishmaniasis represent an unusual form of granulomatous dermatitis caused by Leishmania species, a protozoan transmitted by sandfly bites. As the disease is not native to North America, clinical suspicion is partially based on a compatible travel history and may result in a biopsy. The key role of standard morphology is the identification of Leishmania organisms, supplemented by Giemsa and/or CD1a immunostaining. Histologically, the organism may be confused with Histoplasma species, which is resolved by staining with methenamine silver or PAS...
October 16, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30320628/an-immune-suppression-associated-ebv-positive-anaplastic-large-cell-lymphoma-with-a-braf-v600e-mutation
#14
Alejandro A Gru, Eli Williams, Jacqueline M Junkins-Hopkins
Iatrogenic lymphoproliferative disorders have been described in patients receiving immunosuppressive/immunomodulatory agents outside the transplantation setting. Novel biological agents such as TNF-α blockers and JAK-inhibitors have also proven to be effective in many disorders including rheumatoid arthritis, inflammatory bowel disease (ulcerative colitis and Crohn disease), psoriasis, and others. A significant dilemma exists in those lymphoproliferative disorders associated with immunosuppressants and rheumatologic conditions, that relies on whether the association of the process is with the medication or the underlying autoimmune condition...
October 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30303819/somatic-mutations-of-tsc2-or-mtor-characterize-a-morphologically-distinct-subset-of-sporadic-renal-cell-carcinoma-with-eosinophilic-and-vacuolated-cytoplasm
#15
Ying-Bei Chen, Leili Mirsadraei, Gowtham Jayakumaran, Hikmat A Al-Ahmadie, Samson W Fine, Anuradha Gopalan, S Joseph Sirintrapun, Satish K Tickoo, Victor E Reuter
The differential diagnosis of renal cell neoplasms with solid or nested architecture and eosinophilic cytoplasm has become increasingly complex. Despite recent advances in classifying a number of entities exhibiting this morphology, some tumors remain in the unclassified category. Here we describe a morphologically distinct group of sporadic renal cell carcinoma (RCC) with predominantly nested architecture, eosinophilic, and remarkably vacuolated cytoplasm retrospectively identified from a cohort of previously unclassified tumors...
October 9, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30303818/recurrent-genomic-alterations-in-soft-tissue-perineuriomas
#16
Jodi M Carter, Yanhong Wu, Melissa M Blessing, Andrew L Folpe, Erik C Thorland, Robert J Spinner, Mark E Jentoft, Chen Wang, Saurabh Baheti, Zhiyv Niu, Michelle L Mauermann, Christopher J Klein
Perineuriomas are rare nerve sheath tumors, divided into intraneural and extraneural (soft tissue) types. Intraneural perineuriomas frequently contain TRAF7 mutations, and rarely, chr22q12 deletions. While chr22q losses can occur in soft tissue perineuriomas, comprehensive high-resolution molecular profiling has not been reported in these tumors and TRAF7 status is unknown. We used whole-exome sequencing and OncoScan single nucleotide polymorphism (SNP) array to evaluate 14 soft tissue perineuriomas. Thirteen cases showed 2 or more chromosomal abnormalities, composed primarily of large deletions...
October 9, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30300147/gleason-grading-there-is-no-substitute-for-judgment
#17
Murali Varma
No abstract text is available yet for this article.
October 8, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30300146/gleason-grading-clear-and-straightforward-rules-facilitate-judgment
#18
Kiril Trpkov, Asli Yilmaz, Sakkarn Sangkhamanon, Shaun Medlicott, Bryan Donnelly, Geoffrey Gotto, Melissa Shea-Budgell
No abstract text is available yet for this article.
October 8, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30285997/adamantinoma-like-ewing-sarcoma-of-the-salivary-glands-a-newly-recognized-mimicker-of-basaloid-salivary-carcinomas
#19
Lisa M Rooper, Vickie Y Jo, Cristina R Antonescu, Vania Nose, William H Westra, Raja R Seethala, Justin A Bishop
Adamantinoma-like Ewing sarcoma (ALES) is a rare tumor that demonstrates the EWSR1-FLI1 translocation characteristic of Ewing sarcoma despite overt epithelial differentiation including diffuse expression of cytokeratins and p40. Most cases of ALES described to date have occurred in the head and neck where they can mimic a wide range of small round blue cell tumors. Because distinguishing ALES from basaloid salivary gland carcinomas can be particularly difficult, we analyzed a series of 10 ALESs that occurred in the salivary glands with the aim of identifying features that allow for better recognition of this entity...
October 3, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30285995/vstm2a-overexpression-is-a-sensitive-and-specific-biomarker-for-mucinous-tubular-and-spindle-cell-carcinoma-mtscc-of-the-kidney
#20
Lisha Wang, Yuping Zhang, Ying-Bei Chen, Stephanie L Skala, Hikmat A Al-Ahmadie, Xiaoming Wang, Xuhong Cao, Brendan A Veeneman, Jin Chen, Marcin Cieślik, Yuanyuan Qiao, Fengyun Su, Pankaj Vats, Javed Siddiqui, Hong Xiao, Evita T Sadimin, Jonathan I Epstein, Ming Zhou, Ankur R Sangoi, Kiril Trpkov, Adeboye O Osunkoya, Giovanna A Giannico, Jesse K McKenney, Pedram Argani, Satish K Tickoo, Victor E Reuter, Arul M Chinnaiyan, Saravana M Dhanasekaran, Rohit Mehra
Our recent study revealed recurrent chromosomal losses and somatic mutations of genes in the Hippo pathway in mucinous tubular and spindle cell carcinoma (MTSCC). Here, we performed an integrative analysis of 907 renal cell carcinoma (RCC) samples (combined from The Cancer Genome Atlas and in-house studies) and the Knepper data set of microdissected rat nephrons. We identified VSTM2A and IRX5 as novel cancer-specific and lineage-specific biomarkers in MTSCC. We then assessed their expression by RNA in situ hybridization (ISH) in 113 tumors, including 33 MTSCC, 40 type 1 papillary RCC, 8 type 2 papillary RCC, 2 unclassified RCC, 15 clear cell RCC, and 15 chromophobe RCC...
October 3, 2018: American Journal of Surgical Pathology
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