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American Journal of Surgical Pathology

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https://www.readbyqxmd.com/read/29135520/epithelial-myoepithelial-carcinoma-frequent-morphologic-and-molecular-evidence-of-preexisting-pleomorphic-adenoma-common-hras-mutations-in-plag1-intact-and-hmga2-intact-cases-and-occasional-tp53-fbxw7-and-smarcb1-alterations-in-high-grade-cases
#1
Soufiane El Hallani, Aaron M Udager, Diana Bell, Isabel Fonseca, Lester D R Thompson, Adel Assaad, Abbas Agaimy, Alyssa M Luvison, Caitlyn Miller, Raja R Seethala, Simion Chiosea
We hypothesized that there is a relationship between the preexisting pleomorphic adenoma [PA]), histologic grade of epithelial-myoepithelial carcinomas (EMCAs), and genetic alterations. EMCAs (n=39) were analyzed for morphologic and molecular evidence of preexisting PA (PLAG1, HMGA2 status by fluorescence in situ hybridization, FISH, and FGFR1-PLAG1 fusion by next-generation sequencing, NGS). Twenty-three EMCAs were further analyzed by NGS for mutations and copy number variation in 50 cancer-related genes. On the basis of combined morphologic and molecular evidence of PA, the following subsets of EMCA emerged: (a) EMCAs with morphologic evidence of preexisting PA, but intact PLAG1 and HMGA2 (12/39, 31%), (b) Carcinomas with PLAG1 alterations (9/39, 23%), or (c) HMGA2 alterations (10/39, 26%), and (d) de novo carcinomas, without morphologic or molecular evidence of PA (8/39, 21%)...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29135519/syphilis-of-the-aerodigestive-tract
#2
Julie Y Tse, May P Chan, Judith A Ferry, Vikram Deshpande, Aliyah R Sohani, Valentina Nardi, Andras Schaffer, Rosalynn M Nazarian, Lawrence R Zukerberg
Syphilis, a sexually transmitted infection caused by the Gram-negative bacterium Treponema pallidum, is increasing in prevalence in the United States. It has been our experience that primary and secondary syphilis of the aerodigestive tract can afflict a large age spectrum with varied clinical and histopathologic findings, which can lead to diagnostic problems and frequent misdiagnosis. In this study, we describe the histopathologic patterns of syphilis of the aerodigestive tract to expand awareness of its varied appearance...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29135518/substantial-interobserver-agreement-in-the-diagnosis-of-dysplasia-in-barrett-esophagus-upon-review-of-a-patient-s-entire-set-of-biopsies
#3
Marcela A Salomao, Dora Lam-Himlin, Rish K Pai
The pathologic diagnosis of dysplasia in Barrett esophagus (BE) suffers from interobserver disagreement. Many of the studies demonstrating disagreement in the diagnosis of dysplasia have pathologists review individual biopsy slides in isolation. To more closely mimic daily practice, 3 pathologists reviewed hematoxylin and eosin slides made from 549 individual biopsy jars obtained from 129 unique patients with a diagnosis of BE. Each pathologist reviewed the entirety of a given patient's biopsy material. The grade of dysplasia present in each biopsy jar was given as well as an overall highest grade of dysplasia from the patient's entire set of biopsies...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29135517/myb-translocation-status-in-salivary-gland-epithelial-myoepithelial-carcinoma-evaluation-of-classic-variant-and-hybrid-forms
#4
Justin A Bishop, William H Westra
Epithelial-myoepithelial carcinoma (EMC) is a malignant salivary gland neoplasm comprised of a biphasic arrangement of inner luminal ductal cells and outer myoepithelial cells. Adenoid cystic carcinoma (AdCC) is also a biphasic tumor comprised of ductal and myoepithelial cells, but these components tend to be arranged in a more cribriform pattern. The occurrence of "hybrid carcinomas" that show mixed patterns of EMC and AdCC raises questions about the relationship of these morphologically overlapping but clinically distinct tumors...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29135516/international-endocervical-adenocarcinoma-criteria-and-classification-iecc-a-new-pathogenetic-classification-for-invasive-adenocarcinomas-of-the-endocervix
#5
Simona Stolnicu, Iulia Barsan, Lien Hoang, Prusha Patel, Cristina Terinte, Anna Pesci, Sarit Aviel-Ronen, Takako Kiyokawa, Isabel Alvarado-Cabrero, Malcolm C Pike, Esther Oliva, Kay J Park, Robert A Soslow
We sought to classify endocervical adenocarcinomas (ECAs) based on morphologic features linked to etiology (ie, human papillomavirus [HPV] infection), unlike the World Health Organization 2014 classification. The International Endocervical Adenocarcinoma Criteria and Classification (IECC criteria), described herein, distinguishes between human papillomavirus-associated adenocarcinoma (HPVA), recognized by the presence of luminal mitoses and apoptosis seen at scanning magnification, and no or limited HPVA features (nonhuman papillomavirus-associated adenocarcinoma [NHPVA])...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29112020/distinguishing-neurofibroma-from-desmoplastic-melanoma-the-value-of-p53
#6
Ashley Elsensohn, Jessica Shiu, Narina Grove, Anna-Marie Hosking, Ronald Barr, Sébastien de Feraudy
Distinguishing desmoplastic melanomas (DMs) from neurofibromas (NFs) can be histologically challenging in some cases. To date, a reliable marker to differentiate the 2 entities has remained elusive. S100 subtyping and CD34 fingerprinting have been proposed, but controversy remains as to their reliability. Missense mutations in TP53 are often found in DMs, resulting in a dominant negative effect and paradoxical accumulation of the tumor suppressor protein p53. We hypothesized that p53 may be expressed differentially in DMs, making it a valuable tool in differentiating DMs from NFs...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29112019/utility-of-p16-immunohistochemistry-in-evaluating-negative-cervical-biopsies-following-high-risk-pap-test-results
#7
Alana F Shain, Shirley Kwok, Ann K Folkins, Christina S Kong
The Lower Anogenital Squamous Terminology (LAST) Standardization Project for human papilloma virus (HPV)-associated lesions specifically recommends the use of p16 immunohistochemistry (IHC) as an adjunct to morphologic assessment of cervical biopsies interpreted as negative or low-grade squamous intraepithelial lesion (LSIL) from patients with prior high-risk Pap test results (high-grade squamous intraepithelial lesion [HSIL], atypical squamous cells cannot exclude HSIL, atypical glandular cells [AGC], or HPV16 atypical squamous cells of undetermined significance [ASC-US])...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29112018/tumor-budding-and-pdc-grade-are-stage-independent-predictors-of-clinical-outcome-in-mismatch-repair-deficient-colorectal-cancer
#8
Éanna Ryan, Yi Ling Khaw, Ben Creavin, Robert Geraghty, Elizabeth J Ryan, David Gibbons, Ann Hanly, Sean T Martin, P Ronan O'Connell, Desmond C Winter, Kieran Sheahan
Mismatch repair deficient (dMMR) colorectal cancer (CRC) despite its association with poor histologic grade often has improved prognosis compared with MMR proficient CRC. Tumor budding and poorly differentiated clusters (PDCs) may predict metastatic potential of colorectal adenocarcinoma (CRC). In addition, their assessment may be more reproducible than the evaluation of other histopathologic parameters. Therefore, we wished to determine their potential as prognostic indicators in a cohort of dMMR CRC patients relative to histologic grade...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29112017/neoplastic-lesions-of-gastric-adenocarcinoma-and-proximal-polyposis-syndrome-gapps-are-gastric-phenotype
#9
Willem B de Boer, Hooi Ee, Marian P Kumarasinghe
Neoplastic lesions of gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) are gastric phenotype. GAPPS was reported in 2011 as a new autosomal dominant gastric polyposis syndrome characterized by involvement of the gastric body/fundus with sparing of the antrum by multiple polyps, reported to be primarily fundic gland polyps (FGPs), with progression to dysplasia and adenocarcinoma of intestinal type. Our series consists of 51 endoscopic biopsies and 5 gastrectomy specimens from 25 patients belonging to a previously defined GAPPS family...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29112016/b-lymphoblastic-leukemia-lymphoma-with-burkitt-like-morphology-and-igh-myc-rearrangement-report-of-3-cases-in-adult-patients
#10
Yiting Li, Gunjan Gupta, Ari Molofsky, Yi Xie, Nader Shihabi, Jane McCormick, Elaine S Jaffe
Isolated MYC rearrangement without other recurrent genetic abnormalities is rare in B lymphoblastic leukemia/lymphoma (B-ALL/LBL), with most cases reported in pediatric patients. We report 3 adult cases with lymphoblasts showing a precursor B cell immunophenotype, and isolated MYC/IGH translocation. All 3 cases occurred in male patients with initial presentation of diffuse lymphadenopathy. Cases 1 and 2 had B-ALL with significantly increased lymphoblasts in peripheral blood and bone marrow. Case 3, a patient with human immunodeficiency virus infection, had the diagnosis of B-LBL made on a retroperitoneal lymph node biopsy and had no peripheral blood or bone marrow involvement...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29112015/pd-l1-and-pd-l2-are-differentially-expressed-by-macrophages-or-tumor-cells-in-primary-cutaneous-diffuse-large-b-cell-lymphoma-leg-type
#11
Sarah Menguy, Martina Prochazkova-Carlotti, Marie Beylot-Barry, Fréderic Saltel, Béatrice Vergier, Jean-Philippe Merlio, Anne Pham-Ledard
As checkpoint molecules' inhibition may represent a therapeutic option in relapsing cases, we assessed programmed death ligands' (PD-L1/PD-L2) expression in a series of 29 primary cutaneous diffuse large B-cell lymphoma, leg-type (PCDLBCL-LT) cases. Double immunostaining for either PD-L1 or PD-L2 was associated either with PAX5 staining to evaluate tumor cells or with CD68 or CD163 staining for macrophages. The microenvironment of PCDLBCL-LT was characterized by immunostainings for CD3 (tumor-infiltrating lymphocytes), FOXP3 (regulatory T cells), programmed cell death-1, and CD33 (myeloid-derived suppressor cells)...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29112014/hpv-e6-e7-mrna-in-situ-hybridization-in-the-diagnosis-of-cervical-low-grade-squamous-intraepithelial-lesions-lsil
#12
Anne M Mills, Joseph D Coppock, Brian C Willis, Mark H Stoler
Cervical low-grade squamous intraepithelial lesions (LSIL) (aka cervical intraepithelial neoplasia, grade 1 [CIN1]) can present considerable diagnostic challenges and are associated with poor interobserver reproducibility and overdiagnosis. Furthermore, ancillary studies such as p16 immunohistochemistry have shown little utility in resolving the LSIL versus negative/reactive differential. Human papillomavirus (HPV) RNA in situ hybridization (ISH) has shown promise as a diagnostic aid in this setting, but has not been studied in a large case series...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29112013/cancer-therapy-associated-lymphoproliferative-disorders-an-under-recognized-type-of-immunodeficiency-associated-lymphoproliferative-disorder
#13
Sergio Pina-Oviedo, Roberto N Miranda, L Jeffrey Medeiros
We describe the clinicopathologic features of 17 patients who had a hematologic malignancy of various types, were treated, and subsequently developed a lymphoproliferative disorder (LPD). There were 10 men and 7 women with a median age of 59 years (range, 36 to 83 y). The primary hematologic neoplasms included: 5 chronic lymphocytic leukemia/small lymphocytic lymphoma, 3 plasma cell myeloma, 2 acute monoblastic leukemia, and 1 case each of mixed-phenotype acute leukemia, chronic myeloid leukemia, splenic marginal zone lymphoma, follicular lymphoma, mantle cell lymphoma, T-cell prolymphocytic leukemia, and peripheral T-cell lymphoma...
November 3, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29076877/the-role-of-molecular-testing-in-the-differential-diagnosis-of-salivary-gland-carcinomas
#14
Alena Skálová, Göran Stenman, Roderick H W Simpson, Henrik Hellquist, David Slouka, Tomas Svoboda, Justin A Bishop, Jennifer L Hunt, Ken-Ichi Nibu, Alessandra Rinaldo, Vincent Vander Poorten, Kenneth O Devaney, Petr Steiner, Alfio Ferlito
Salivary gland neoplasms are a morphologically heterogenous group of lesions that are often diagnostically challenging. In recent years, considerable progress in salivary gland taxonomy has been reached by the discovery of tumor type-specific fusion oncogenes generated by chromosome translocations. This review describes the clinicopathologic features of a selected group of salivary gland carcinomas with a focus on their distinctive genomic characteristics. Mammary analog secretory carcinoma is a recently described entity characterized by a t(12;15)(p13;q25) translocation resulting in an ETV6-NTRK3 fusion...
October 26, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29076876/loss-of-bap1-expression-in-atypical-mesothelial-proliferations-helps-to-predict-malignant-mesothelioma
#15
Raghavendra Pillappa, Joseph J Maleszewski, William R Sukov, Patrick P Bedroske, Patricia T Greipp, Jennifer M Boland, Eunhee S Yi, Tobias Peikert, Marie Christine Aubry, Anja C Roden
Distinguishing reactive mesothelial proliferation from malignant mesothelioma (MM) can be difficult, particularly on small biopsies. In this scenario, a diagnosis of atypical mesothelial proliferation might be rendered. However, the distinction between a reactive process and MM is important for prognosis and treatment. Recently, loss of BRCA1-associated protein 1 (BAP1) expression and/or homozygous deletion of CDKN2A were identified in some MM, but not in reactive mesothelial proliferations. We studied 34 cases of atypical mesothelial proliferation from our institutional files (1993 to 2016) for BAP1 expression, deletion of CDKN2A, and clinical outcome...
October 26, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29076875/ovarian-microcystic-stromal-tumors-are-characterized-by-alterations-in-the-beta-catenin-apc-pathway-and-may-be-an-extracolonic-manifestation-of-familial-adenomatous-polyposis
#16
(no author information available yet)
No abstract text is available yet for this article.
October 26, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29076874/clear-cell-carcinoma-of-salivary-glands-is-frequently-p16-positive-a-pitfall-in-the-interpretation-of-oropharyngeal-biopsies
#17
Justin A Bishop, Lisa M Rooper, Simion I Chiosea, William H Westra
Clear cell carcinoma (CCC) is a low-grade malignancy that commonly arises in minor salivary glands of the oropharynx and other sites. EWSR1-ATF1 gene fusions seem to be specific for this salivary neoplasm. Testing for EWSR1-ATF1 has expanded the histologic spectrum of CCC. As one important example, many CCCs have a predominantly squamous phenotype with few clear cells, a finding that can cause confusion with squamous cell carcinoma (SqCC). P16 immunohistochemical staining to determine human papillomavirus (HPV) status has become standard practice for all oropharyngeal carcinomas showing squamous differentiation...
October 26, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29076873/molecular-profiling-of-mammary-analog-secretory-carcinoma-revealed-a-subset-of-tumors-harboring-a-novel-etv6-ret-translocation-report-of-10-cases
#18
Alena Skalova, Tomas Vanecek, Petr Martinek, Ilan Weinreb, Todd M Stevens, Roderick H W Simpson, Martin Hyrcza, Niels J Rupp, Martina Baneckova, Michael Michal, David Slouka, Tomas Svoboda, Alena Metelkova, Arghavan Etebarian, Jaroslav Pavelka, Steven J Potts, Jason Christiansen, Petr Steiner, Michal Michal
ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, and has not been documented in any other salivary tumor type. The present study comprised a clinical, histologic, and molecular analysis of 10 cases of secretory carcinoma, with typical morphology and immunoprofile harboring a novel ETV6-RET translocation...
October 26, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29076872/analysis-of-t1-bladder-cancer-on-biopsy-and-transurethral-resection-specimens-comparison-and-ranking-of-t1-quantification-approaches-to-predict-progression-to-muscularis-propria-invasion
#19
Mariah Z Leivo, Debashis Sahoo, Zachary Hamilton, Leili Mirsadraei, Ahmed Shabaik, John K Parsons, Andrew K Kader, Ithaar Derweesh, Christopher Kane, Donna E Hansel
Urothelial carcinoma of the bladder invasive into lamina propria on biopsy or transurethral resection of bladder tumor, termed "T1" disease, progresses to muscularis propria invasion in a subset of patients. Prior studies have proposed histopathologic metrics to predict progression, although methods vary widely and it is unclear which method is most robust. This poses a challenge since recent World Health Organization and American Joint Commission on Cancer editions encourage some attempt to substratify T1 disease...
October 26, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29076871/olfactory-epithelial-hamartoma-a-new-subtype-of-sinonasal-hamartoma
#20
Myriam Kossai, Sophie El Zein, Michel Wassef, Jean-Pierre Guichard, Christelle Pouliquen, Philippe Herman, Benjamin Vérillaud, Marion Classe
Sinonasal epithelial hamartomas occurring in adults are classified as seromucinous hamartoma (SMH) or respiratory epithelial adenomatoid hamartoma (REAH). We describe herein a novel subtype of adult sinonasal hamartoma that contains olfactory epithelium, a histologic feature not previously reported in the literature. Our pathology department database was retrospectively searched for sinonasal hamartomas containing areas of olfactory epithelium. Six relevant cases (3 male and 3 female patients; age, 30 to 77 y) were retrieved, and available pathology slides and clinical and imaging data from patient charts were reviewed...
October 26, 2017: American Journal of Surgical Pathology
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