journal
MENU ▼
Read by QxMD icon Read
search

American Journal of Pathology

journal
https://www.readbyqxmd.com/read/29137952/neural-egfl-like-1-regulates-cartilage-maturation-through-runt-related-transcription-factor-3-mediated-indian-hedgehog-signaling
#1
Chenshuang Li, Zhong Zheng, Jie Jiang, Wenlu Jiang, Kevin Lee, Emily A Berthiaume, Eric C Chen, Cymbeline T Culiat, Yan-Heng Zhou, Xinli Zhang, Kang Ting, Chia Soo
The pro-chondrogenic function of runt-related transcription factor 2 (Runx2) was previously considered to be dependent on direct binding with the promoter of Indian hedgehog (Ihh)-the major regulator of chondrocyte differentiation, proliferation, and maturation. Our previous studies identified neural EGFL like 1 (Nell-1) as a Runx2-responsive growth factor for chondrogenic differentiation and maturation. In this study, we further revealed that the pro-chondrogenic activities of Nell-1 also rely on Ihh signaling, by showing: [1] Nell-1 significantly elevated Ihh signal transduction, [2] Nell-1 deficiency markedly reduced Ihh activation in chondrocytes, and [3] Nell-1-stimulated chondrogenesis was significantly reduced by the specific hedgehog inhibitor, cyclopamine...
November 11, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29137951/triple-negative-breast-cancer-stem-cells-and-african-ancestry
#2
REVIEW
Evelyn Jiagge, Dhananjay Chitale, Lisa A Newman
Triple-negative breast cancers (TNBC) are more common among African ancestry populations, such as African Americans and western, sub-Saharan Africans, compared to European ancestry populations. This phenotype prevalence contributes to breast cancer outcome disparities between African Americans and Caucasian Americans. Breast cancer stem cells represent the tumor subpopulation responsible for metastatic virulence and ongoing research seeks to characterize the extent to which TNBC versus non-TNBC stem cells may differ...
November 11, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29137950/linking-race-cancer-outcomes-and-tissue-repair
#3
REVIEW
Jung S Byun, Samson Park, Ambar Caban, Alana Jones, Kevin Gardner
The burden of cancer in the United States is unevenly spread across its different populations, with stark differences in both disease prevalence and outcome based on race and ethnicity. Although a large portion of these differences can be explained by a variety of socio-behavioral and socio-economic factors, even after these exposures are taken into consideration, significant disparities persist. In this review, we explore a conceptual framework of biological theories and unifying concepts, based on an evolutionary perspective, that may help better define common guiding principles for exploration of underlying etiologies of cancer health disparities...
November 11, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29137949/the-science-of-cancer-health-disparities
#4
EDITORIAL
Kevin Gardner
This Guest Editorial highlights the reviews in Race in Cancer Health Disparities Theme Issue that improve our understanding of the complex role of race in disparities in cancer frequency and outcome.
November 11, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29137948/analysis-of-tumor-biology-to-advance-cancer-health-disparity-research
#5
REVIEW
Cheryl Jacobs Smith, Tsion Zewdu Minas, Stefan Ambs
Cancer mortality rates in the US continue to decline. Reductions in tobacco use, uptake of preventive measures, adoption of early detection methods, and better treatments have resulted in improved cancer outcomes for men and women. Despite this progress, some population groups continue to experience an excessive cancer burden when compared with other population groups. One of the most prominent cancer health disparities exists in prostate cancer. Prostate cancer mortality rates are highest among men of African ancestry when compared with other men, both in the US and globally...
November 11, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29132929/a-new-scope-and-a-new-editorial-team-for-the-american-journal-of-pathology
#6
EDITORIAL
Martha B Furie
No abstract text is available yet for this article.
November 10, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29132928/this-month-in-ajp
#7
(no author information available yet)
The following highlights summarize research articles that are published in the current issue of The American Journal of Pathology.
November 10, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29128569/lysophosphatidic-acid-receptor-1-is-important-for-intestinal-epithelial-barrier-function-and-susceptibility-to-colitis
#8
Songbai Lin, Yiran Han, Kayte Jenkin, Sei-Jung Lee, Maiko Sasaki, Jan-Michael Klapproth, Peijian He, C Chris Yun
Intestinal epithelial cells form a barrier that is critical in protecting the host from the hostile luminal environment. Previously, we showed that lysophosphatidic acid receptor 1 (LPAR1) regulates proliferation of intestinal epithelial cells such that the absence of LPA1 mitigates epithelial wound healing process. This study provides evidence that LPA1 is important for the maintenance of epithelial barrier integrity. The epithelial permeability, determined by fluorescently labeled dextran flux and transepithelial resistance, is increased in Lpar1(-/-) (Lpa1(-/-)) mouse intestine...
November 8, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29128568/race-in-cancer-health-disparities-theme-issue-colorectal-cancer-disparity-in-african-americans-risk-factors-and-carcinogenic-mechanisms
#9
REVIEW
Gaius J Augustus, Nathan A Ellis
African Americans have the highest incidence and mortality rates of colorectal cancer (CRC) of any ethnic group in the United States. Although some of these disparities can be explained by differences in access to care, cancer screening, and other socioeconomic factors, disparities remain after adjustment for these factors. Consequently, an examination of recent advances in the understanding of ethnicity-specific factors, including genetic and environmental factors relating to risk of CRC, the biology of CRC progression, and the changes in screening and mortality, is important for evaluating our progress towards eliminating the disparities...
November 8, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29128567/haploinsufficiency-of-hnrnp-u-changes-activity-pattern-and-metabolic-rhythms
#10
Beibei Lai, Jianghuan Zou, Zhaoyu Lin, Zhipeng Qu, Anying Song, Ying Xu, Xiang Gao
The neuropeptides arginine vasopressin (Avp) and vasoactive intestinal polypeptide (Vip) are critical for the communication and coupling of suprachiasmatic nucleus neurons, which organize daily rhythms of physiology and behavior in mammals. However, how these peptides are regulated remains uncharacterized. Here, we demonstrate that heterogeneous nuclear ribonucleoprotein U (hnRNP U) is essential for the expression of Avp and Vip. Loss of one copy of the Hnrnpu gene resulted in fragmented locomotor activities and disrupted metabolic rhythms...
November 8, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29128566/restoration-of-polr1c-in-early-embryogenesis-rescues-the-type-3-treacher-collins-syndrome-facial-malformation-phenotype-in-zebrafish
#11
Ernest Man Lok Kwong, Jeff Cheuk Hin Ho, Marco Chi Chung Lau, May-Su You, Yun-Jin Jiang, William Ka Fai Tse
Treacher Collins Syndrome (TCS) is a rare congenital birth disorder (1 in 50,000 live births) characterized by severe craniofacial defects. Recently, our group unfolded the pathogenesis of polr1c Type 3 TCS by using the zebrafish model. Facial development depends on the neural crest cells, in which polr1c plays a role in regulating its expression. In this report, we aim to identify the functional time window of polr1c in TCS by the use of photo-morpholino to restore the polr1c expression at different time points...
November 8, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29128565/obesity-and-triple-negative-breast-cancer-disparities-controversies-and-biology
#12
REVIEW
Eric C Dietze, Tanya A Chavez, Victoria L Seewaldt
Once considered a problem of Western nations, obesity (body mass index ≥30kg/m(2)) has rapidly increased since the 1970s to become a major threat to world health. Since 1970, the face of obesity has changed from a disease of affluence and abundance to a disease of poverty. Over the last 10 years, studies have mechanistically linked obesity and an obese tumor microenvironment with signaling pathways that predict aggressive breast cancer biology. For example, in the United States African-American women are more likely than non-Hispanic European-American women to be obese and to be diagnosed with triple-negative breast cancer (TNBC)...
November 8, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29128564/epigenetic-mechanisms-of-atm-activation-after-helicobacter-pylori-infection
#13
Juliana Carvalho Santos, Rafael Zuppardo Gambeloni, Aline Tengan Roque, Sebastian Oeck, Marcelo Lima Ribeiro
Gastric cancer (GC) is the second leading cause of cancer-related mortality worldwide. The disease develops from the accumulation of several genetic and epigenetic changes. Among other risk factors, Helicobacter pylori infection is considered the main driving factor of GC development. H. pylori infection increases DNA damage levels and leads to epigenetic dysregulation, which may favor gastric carcinogenesis. An early step in double strand break repair is the recruitment of (ataxia-telangiectasia mutated serine/threonine kinase (ATM) to the damaged site, where it plays a key role in advancing the DNA damage checkpoint process...
November 8, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29128563/matrin-3-is-a-component-of-neuronal-cytoplasmic-inclusions-of-motor-neurons-in-sporadic-amyotrophic-lateral-sclerosis
#14
Mikiko Tada, Hiroshi Doi, Shigeru Koyano, Shun Kubota, Ryoko Fukai, Shunta Hashiguchi, Noriko Hayashi, Yuko Kawamoto, Misako Kunii, Kenichi Tanaka, Keita Takahashi, Yuki Ogawa, Ryo Iwata, Shoji Yamanaka, Hideyuki Takeuchi, Fumiaki Tanaka
Mutations in the matrin 3 (MATR3) gene have been identified as a cause of familial amyotrophic lateral sclerosis, but the involvement of MATR3 protein in sporadic amyotrophic lateral sclerosis (SALS) pathology has not been fully assessed. Here, we immunohistochemically analyzed MATR3 pathology in the spinal cords of SALS and control autopsies. MATR3 immunostaining of the motor neuron nuclei revealed two distinct patterns, mild and strong staining. There were no differences in the ratio of mild versus strong nuclear staining between the SALS and control cases...
November 8, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29126837/antiandrogens-reduce-intratumoral-androgen-concentrations-and-induce-androgen-receptor-expression-in-castration-resistant-prostate-cancer-xenografts
#15
Matias Knuuttila, Arfa Mehmood, Riikka Huhtaniemi, Emrah Yatkin, Merja R Häkkinen, Riikka Oksala, Teemu D Laajala, Henrik Ryberg, David J Handelsman, Tero Aittokallio, Seppo Auriola, Claes Ohlsson, Asta Laiho, Laura L Elo, Petra Sipilä, Sari I Mäkelä, Matti Poutanen
The development of castration-resistant prostate cancer (CRPC) is associated with the activation of intratumoral androgen biosynthesis and an increase in androgen receptor (AR) expression. We recently demonstrated that similarly to the clinical CRPC, orthotopically grown castration-resistant VCaP (CR-VCaP) xenografts express high levels of AR and retain intratumoral androgen concentrations similar to tumors grown in intact mice. Here, we show that antiandrogen treatment (enzalutamide or ARN-509) significantly reduced (10-fold, P < 0...
November 7, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29128099/regulation-of-cellular-senescence-by-mir-34a-in-alcoholic-liver-injury
#16
Ying Wan, Kelly McDaniel, Nan Wu, Sugeily Ramos-Lorenzo, Trenton Glaser, Julie Venter, Heather Francis, Lindsey Kennedy, Keisaku Sato, Tianhao Zhou, Konstantina Kyritsi, Qiaobing Huang, Tami Annable, Chaodong Wu, Shannon Glaser, Gianfranco Alpini, Fanyin Meng
Alcoholic liver disease remains a major cause of liver-related morbidity and mortality, which ranges from alcoholic steatohepatitis to fibrosis/cirrhosis and hepatocellular carcinoma, and the related mechanisms are understood poorly. In this study, we aimed to investigate the role of miR-34a in alcohol-induced cellular senescence and liver fibrosis. We found that hepatic miR-34a expression was upregulated in ethanol-fed mice and heavy drinkers with steatohepatitis compared with respective controls. Mice treated with miR-34a Vivo-Morpholino developed less severe liver fibrosis than wild-type mice after 5 weeks of ethanol feeding...
November 2, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29107075/the-role-of-extracellular-histones-in-influenza-virus-pathogenesis
#17
Harshini K Ashar, Nathan C Mueller, Jennifer M Rudd, Timothy A Snider, Mallika Achanta, Maram Prasanthi, Sivasami Pulavendran, Paul G Thomas, Ramachandran Akhilesh, Jerry R Malayer, Jerry W Ritchey, Rachakatla Rajasekhar, Vincent Tk Chow, Charles T Esmon, Narasaraju Teluguakula
Although exaggerated host immune responses have been implicated in influenza-induced lung pathogenesis, the etiological factors that contribute to these events are not completely understood. We have previously demonstrated that neutrophil extracellular traps exacerbate pulmonary injury during influenza pneumonia. Histones are the major protein components of neutrophil extracellular traps and are known to have cytotoxic effects. Here, we examined the role of extracellular histones in lung pathogenesis during influenza...
October 26, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29107074/loss-of-%C3%AE-epithelial-sodium-channel-function-in-meibomian-glands-produces-pseudohypoaldosteronism-1-like-ocular-disease-in-mice
#18
Dongfang Yu, Yogesh Saini, Gang Chen, Andrew J Ghio, Hong Dang, Kimberlie A Burns, Yang Wang, Richard M Davis, Scott H Randell, Charles R Esther, Friedrich Paulsen, Richard C Boucher
Human subjects with pseudohypoaldosteronism-1 due to loss of function mutations in epithelial Na(+) channel (ENaC) subunits exhibit meibomian gland (MG) dysfunction. A conditional βENaC MG knockout mouse model was generated to elucidate the pathogenesis of absent ENaC function in the MG and associated ocular surface disease. βENaC MG KO mice exhibited a striking age dependent, female predominant MG dysfunction phenotype, with white toothpaste-like secretions observed obstructing MG orifices at seven weeks of age...
October 26, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29107073/immuno-metabolic-determinants-of-chemoradiotherapy-response-and-survival-in-head-and-neck-squamous-cell-carcinoma
#19
Rosemarie Krupar, Matthias G Hautmann, Ravi R Pathak, Indu Varier, Cassandra McLaren, Doris Gaag, Claus Hellerbrand, Matthias Evert, Simon Laban, Christian Idel, Vlad Sandulache, Sven Perner, Anja K Bosserhoff, Andrew G Sikora
Tumor immune microenvironment and tumor metabolism are major determinants of chemoradiotherapy response. We assessed the interdependency and prognostic significance of specific immune and metabolic phenotypes in head and neck squamous cell carcinoma (HNSCC) and evaluated changes in reactive oxygen species as a mechanism of treatment response in tumor spheroid/immunocyte co-cultures. Pretreatment tumor biopsies were immunohistochemically characterized in a cohort of 73 HNSCC patients treated by definitive chemoradiotherapy and correlated with survival...
October 26, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29107072/ectopic-phosphorylated-creb-marks-dedifferentiated-proximal-tubules-in-cystic-kidney-disease
#20
Pawan Puri, Caitlin M Schaefer, Daniel Bushnell, Mary E Taglienti, Jordan A Kreidberg, Bradley K Yoder, Carlton M Bates
Ectopic cAMP signaling is pathological in polycystic kidney disease; however, its spatio-temporal actions are unclear. We characterized expression of phosphorylated Creb (p-Creb), a target and mediator of cAMP signaling, in developing and cystic kidney models. We also examined tubule-specific effects of cAMP analogs in cystogenesis in embryonic kidney explants. In wild-type mice, p-Creb marked nephron progenitors (NP), early epithelial NP derivatives, ureteric bud, and cortical stroma; p-Creb was present in differentiated thick ascending limb of Henle, collecting duct, and stroma; however, it disappeared in mature NP-derived proximal tubules...
October 26, 2017: American Journal of Pathology
journal
journal
20018
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"