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American Journal of Ophthalmology

Zhichao Wu, Felipe A Medeiros, Robert N Weinreb, Linda M Zangwill
PURPOSE: To compare the performance of the pattern standard deviation (PSD) values derived from the central 12 locations of the 24-2 visual field test (C24-2) to the entire 10-2 test for detecting central visual field abnormalities in eyes with, suspected or at risk of having glaucoma. DESIGN: Cross-sectional, case-control study METHODS: Eyes with, suspected or at risk of having glaucoma, based on masked grading of optic disc stereophotographs and/or ocular hypertension (intraocular pressure ≥22 mm Hg) were included as cases (n=523)...
August 9, 2018: American Journal of Ophthalmology
Won June Lee, Kyeong Ik Na, Ahnul Ha, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To evaluate patterns of glaucomatous structural progression using the combined retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) event-based progression analysis feature provided by spectral-domain optical coherence tomography (SD-OCT)'s Guided Progression Analysis (GPA) software. DESIGN: Retrospective observational case series. METHODS: Seventy-nine (79) patients with open-angle glaucoma (OAG) showing clinically confirmed structural progression within a minimum 3-year follow-up period...
August 9, 2018: American Journal of Ophthalmology
Tadamichi Akagi, Akihito Uji, Alex S Huang, Robert N Weinreb, Tatsuya Yamada, Manabu Miyata, Takanori Kameda, Hanako Ohashi Ikeda, Akitaka Tsujikawa
PURPOSE: To investigate conjunctival and intrascleral vasculatures using anterior-segment (AS) optical coherence tomography angiography (OCTA) in normal eyes. DESIGN: Cross-sectional study. METHODS: AS-OCTA images of the corneal limbus were acquired circumferentially using a swept-source OCT system in 10 eyes of 10 healthy subjects. AS-OCTA flow patterns with en face maximum projection were compared between the superficial (from the conjunctival epithelium to a depth of 200 μm) and deep (from a depth of 200 μm to 1000 μm) layers...
August 9, 2018: American Journal of Ophthalmology
Sunee Chansangpetch, Kevin Lau, Claudio I Perez, Ngoc Nguyen, Travis C Porco, Shan C Lin
PURPOSE: To evaluate the effectiveness of trabecular microbypass stent (iStent) implantation in combined mechanism glaucoma (CMG). DESIGN: Retrospective cohort study METHODS: We reviewed the medical charts of patients with the following scenarios: (1) primary open angle glaucoma (POAG) undergoing phacoemulsification (PE), (2) POAG undergoing PE with iStent (POAG-PE/iStent), (3) CMG undergoing PE (CMG-PE), and (4) CMG undergoing PE with iStent (CMG-PE/iStent). CMG was defined as narrow angle glaucoma patients whose angle had opened after iridotomy...
August 8, 2018: American Journal of Ophthalmology
Wei-Boon Khor, Venkatesh N Prajna, Prashant Garg, Jodhbir S Mehta, Lixin Xie, Zuguo Liu, Ma Dominga B Padilla, Choun-Ki Joo, Yoshitsugu Inoue, Panida Goseyarakwong, Fung-Rong Hu, Kohji Nishida, Shigeru Kinoshita, Vilavun Puangsricharern, Ai-Ling Tan, Roger Beuerman, Alvin Young, Namrata Sharma, Benjamin Haaland, Francis S Mah, Elmer Y Tu, Fiona J Stapleton, Richard L Abbott, Donald Tiang-Hwee Tan
PURPOSE: To survey the demographics, risk factors, microbiology and outcomes for infectious keratitis in Asia. DESIGN: Prospective, non-randomized clinical study METHODS: Thirteen study centers and 30 sub-centers recruited consecutive subjects over 12 - 18 months, and performed standardized data collection. A microbiological protocol standardized the processing and reporting of all isolates. Treatment of the infectious keratitis was decided by the managing ophthalmologist...
August 8, 2018: American Journal of Ophthalmology
Emilia Maggio, Mauro Sartore, Marcella Attanasio, Giorgia Maraone, Massimo Guerriero, Antonio Polito, Grazia Pertile
PURPOSE: To report the long-term outcomes of intravitreal anti-VEGF treatment for diabetic macular edema (DME) in a real-world clinical setting and to assess the efficacy of subsequent alternative treatments in eyes with suboptimal response to anti-VEGF. DESIGN: Retrospective interventional case series. METHODS: The medical records of consecutive eyes with center-involving DME, treated between August 2008 and June 2015 with 3 monthly intravitreal anti-VEGF injections - with or without prompt or deferred laser - followed by PRN re-treatment, were reviewed...
August 8, 2018: American Journal of Ophthalmology
Soolienah Rhiu, Suzanne Michalak, Warachaya Phanphruk, David G Hunter
PURPOSE: To describe a phenomenon, depression in attempted abduction, not previously recognized as a feature of Duane syndrome (DS). DESIGN: Retrospective, observational case series METHODS: Setting: Institutional practice PATIENT POPULATION: Patients diagnosed with esotropic DS at Boston Children's Hospital from 2002-2015. Patients with clinical photographs documenting horizontal gaze were included. Patients with prior strabismus surgery were excluded. OBSERVATION PROCEDURES: Patients were classified into 3 groups according to their vertical eye position in attempted abduction: midline group, depression group and elevation group...
August 8, 2018: American Journal of Ophthalmology
Bernardo T Lopes, Isaac C Ramos, Marcella Q Salomão, Frederico P Guerra, Steve C Schallhorn, Julie M Schallhorn, Riccardo Vinciguerra, Paolo Vinciguerra, Fancis W Price, Marianne O Price, Dan Z Reinstein, Timothy J Archer, Michael W Bellin, Aydano P Machado, Renato Ambrósio
PURPOSE: To improve the detection of corneal ectasia susceptibility using tomographic data. DESIGN: Multicenter case control study METHODS: Data from patients from five different clinics from South-America, United States and Europe were evaluated. Artificial intelligence models were generated using Pentacam HR (Oculus, Wetzlar, Germany) parameters to discriminate the preoperative data of three groups: stable LASIK cases (2,980 patients with minimum follow up of 7 years), ectasia susceptibility (71 eyes of 45 patients that developed post-LASIK ectasia [PLE]) and clinical keratoconus (182 patients [KC])...
August 8, 2018: American Journal of Ophthalmology
Yong Wei Wei Dayna, Chai Hui-Chen Charmaine, Shen Liang, Ray Manotosh, Tan Wee Tien Anna
PURPOSE: To compare the outcome in patients with Fuchs Endothelial Dystrophy (FED) who underwent standard phacoemulsification versus Femtosecond Laser-Assisted Surgery (FLACS) in the treatment of visually significant cataracts. DESIGN: Retrospective, comparative, interventional case series METHODS PATIENT OR STUDY POPULATION: : Between April 2013 and December 2016, 140 FED eyes with cataracts of all densities were included. 72 eyes underwent phacoemulsification and 68 eyes underwent FLACS...
August 8, 2018: American Journal of Ophthalmology
Alessandro Arrigo, Emanuela Aragona, Luigi Capone, Luisa Pierro, Francesco Romano, Francesco Bandello, Maurizio Battaglia Parodi
PURPOSE: To analyze optical coherence tomography angiography (OCTA) quantitative features in patients affected by new-onset choroidal neovascularization (CNV) in one eye and early/intermediate age-related macular degeneration (AMD) in the fellow eye. DESIGN: Case-control study. SETTINGS: Clinical Practice. STUDY POPULATION: Thirty patients and thirty age-matched controls. OBSERVATION PROCEDURES: Both cohorts underwent complete ophthalmologic examination, including best corrected visual acuity (BCVA) measurement, biomicroscopy, fluorescein angiography (FA) and indocyanine green angiography (ICGA) examination (Spectralis HRA; Heidelberg Engineering, Germany), OCT and OCTA scans (DRI OCT Triton; Topcon Corporation, Japan)...
August 8, 2018: American Journal of Ophthalmology
Atalie C Thompson, M Tariq Bhatti, Sidney M Gospe
PURPOSE: To use spectral domain-optical coherence tomography (SD-OCT) to assess whether epipapillary vitreous traction from evolving posterior vitreous detachment (PVD) is mechanistically involved in the pathogenesis of non-arteritic anterior ischemic optic neuropathy (NAION). DESIGN: Retrospective cohort study. METHODS: <AbstractText Label="SETTING" NlmCategory="METHODS">Single academic center. PATIENT OR STUDY POPULATION: Eighty eyes in 74 subjects presenting within 2 weeks of symptom onset of NAION...
August 8, 2018: American Journal of Ophthalmology
Louis Cai, Manuel Paez-Escamilla, Scott D Walter, Bercin Tarlan, Christina L Decatur, Barbara M Perez, J William Harbour
PURPOSE: To compare the prognostic accuracy of gene expression profiling (GEP) combined with PRAME status versus the clinical Tumor-Node-Metastasis (TNM) staging in patients with uveal melanoma (UM). DESIGN: Retrospective cohort study. METHODS: The study included 240 consecutive patients with UM. Tumors were assessed for GEP status (Class 1 or Class 2) using a validated 15-gene assay, and PRAME expression status using quantitative PCR. TNM staging was according to the American Joint Committee on Cancer (AJCC) 8th edition...
August 6, 2018: American Journal of Ophthalmology
Youn Joo Choi, Eun Kyu Oh, Min Joung Lee, Namju Kim, Ho-Kyung Choung, Sang In Khwarg
PURPOSE: To investigate the clinical features and risk factors of atypical mycobacterial infection in anophthalmic sockets with porous orbital implant exposure. DESIGN: Case-control study. METHODS: The medical records of all patients who had undergone surgical correction of porous orbital implant exposure were consecutively reviewed, and the patients were stratified as those with atypical mycobacterial infection (AM infection group) and others (non-AM group)...
August 6, 2018: American Journal of Ophthalmology
Jose V Perez-Moreiras, Juan J Gomez-Reino, Jose R Maneiro, Eva Perez-Pampin, Angel Romo Lopez, Fernando M Rodríguez Alvarez, Jesús M Castillo Laguarta, Aurora Del Estad Cabello, María Gessa Sorroche, Enrique España Gregori, Marco Sales-Sanz
OBJECTIVE: To demonstrate the efficacy of the anti- interleukin-6 receptor monoclonal antibody tocilizumab in patients with moderate to severe corticosteroid resistant Graves´ orbitopathy (GO). DESIGN: Double-masked randomized clinical trial SETTING: and Participants: Thirty-two adults with moderate to severe corticosteroid-resistant GO from ten medical centers in Spain were randomized (1:1) INTERVENTION: Randomization to either 8 mg/kg body weight tocilizumab or placebo administered intravenously at weeks 0, 4, 8, and 12, and follow-up for an additional 28 weeks...
August 3, 2018: American Journal of Ophthalmology
Alexandra Lind, Jovanna Dahlgren, Lina Raffa, Kerstin Allvin, Deala Ghazi Mroué, Marita Andersson Grönlund
PURPOSE: To study visual function and ocular fundus morphology in relation to growth, metabolic status and blood pressure in moderate-to-late preterm (MLP) children at 10 years of age. DESIGN: Prospective cohort study. METHODS: In this population-based observational study, non-syndromic MLP children born in Gothenburg, Sweden, were examined neonatally year 2002-2003 concerning length, weight, head circumference and insulin-like growth factor I (IGF-I)...
August 3, 2018: American Journal of Ophthalmology
Hakan Demirci, Leslie M Niziol, Zeynep Ozkurt, Naziha Slimani, Cem Ozgonul, Tiffany Liu, David C Musch, Miguel Materin
PURPOSE: To evaluate the prognostication of choroidal melanoma (CM) by the gene expression profiling (GEP) test DESIGN: Cohort study METHODS: Retrospective review of 293 CM patients from 2 centers RESULTS: Of 293 patients, 132 (45%) were class 1A by GEP, 63 (22%) were class 1B, and 98 (33%) were class 2. Class 2 tumors had more ciliary body involvement, greater largest basal dimension (LBD), and were thicker. GEP results and increasing LBD were independently predictive of time to metastasis...
August 3, 2018: American Journal of Ophthalmology
Ts Vajaranant, Rm Ray, Lr Pasquale, J A Mares, R Ritch, Ew Gower, Mn Haan, Rd Jackson, Pm Maki
PURPOSE: We conducted a secondary analysis of a randomized, placebo-controlled trial to test if hormone therapy (HT) altered the risk of open-angle glaucoma (OAG), and if the risk reduction varied by race. DESIGN: Secondary analysis of randomized controlled trial data Methods: We linked Medicare claims data to 25,535 women in the Women's Health Initiative. Women without a uterus were randomized to receive either oral conjugated equine estrogens (CEE 0.625mg/day) or placebo, and women with a uterus received oral CEE and medroxyprogesterone acetate (CEE 0...
August 3, 2018: American Journal of Ophthalmology
Vitor K L Takahashi, Júlia T Takiuti, Ruben Jauregui, Vinit B Mahajan, Stephen H Tsang
PURPOSE: To determine rate of bone spicule pigmentation appearance in patients with Retinitis Pigmentosa (RP) DESIGN: Retrospective, observational case series. PARTICIPANTS: A total of 240 patients were analyzed for this study METHODS: A retrospective analysis was conducted at the Electrodiagnostic Clinic at Columbia University Medical Center of all patients' medical records with a diagnosis of RP between July 2017 and January 2018. The medical records of these patients were analyzed to determine whether the patients presented with pigment migration on their first and last visit to our clinic...
August 3, 2018: American Journal of Ophthalmology
Mathieu F Bakhoum, K Bailey Freund, Rosa Dolz-Marco, Belinda Cs Leong, Caroline R Baumal, Jay S Duker, David Sarraf
PURPOSE: To analyze the spectrum of ischemia associated with paracentral acute middle maculopathy (PAMM) in eyes with acute retinal vascular occlusion and to describe an ischemic cascade. DESIGN: A retrospective observational case series. METHODS: Patients presenting with PAMM secondary to acute retinal vascular occlusion were identified. Analysis of multimodal imaging was performed at baseline and at follow up visits to elucidate the patterns and progression of ischemia within the retinal layers...
August 3, 2018: American Journal of Ophthalmology
Sunee Chansangpetch, Brendan Tran, Claudio I Perez, Christine Siguan-Bell, Kevin Lau, Anh-Hien Nguyen, Andy Thai, Mingguang He, Dandan Wang, Ngoc Nguyen, Shan C Lin
PURPOSE: To evaluate the difference in anterior segment optical coherence tomography (AS-OCT) parameters among ethnic Vietnamese, Chinese, and Caucasians DESIGN: Cross-sectional study METHODS: We prospectively recruited phakic non-glaucomatous participants (based on intraocular pressure <21 mmHg, normal optic nerve head and retinal nerve fiber, and cup-to-disc ratio <0.6) of three ethnic groups- Vietnamese, Chinese, and Caucasians. AS-OCT parameters including angle (angle opening distance, trabecular-iris space area, and angle recess area), iris (iris thickness, iris area, and iris curvature (Icurv)), and anterior chamber parameters (anterior chamber depth, width (ACW), area, and lens vault (LV)) were obtained...
August 3, 2018: American Journal of Ophthalmology
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