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American Journal of Ophthalmology

Imran Mohammed, Andrew Ross, John O Britton, Dalia G Said, Harminder S Dua
No abstract text is available yet for this article.
October 13, 2018: American Journal of Ophthalmology
Wei-Dar Chen, Yao-Hsu Yang, Chung-Yuan Lee, Chien-Hsiung Lai, Chia-Yen Liu, Li-Ju Lai
PURPOSE: To analyze the incidence and risk of non-infectious uveitis among postdelivery women with a history of preeclampsia/eclampsia. DESIGN: Population-based retrospective matched cohort study. Methods SETTING: All participant data were retrieved from the Longitudinal Health Insurance Database 2005 STUDY POPULATION: 2073 postdelivery women, aged ≥20 years, diagnosed with preeclampsia/eclampsia were included from January 1, 1997 to December 31, 2012. OBSERVATION PROCEDURE(S): A follow-up of 5 years to trace the occurrence of non-infectious uveitis...
October 11, 2018: American Journal of Ophthalmology
Ryo Asaoka, Hiroshi Murata, Kazunori Hirasawa, Yuri Fujino, Masato Matsuura, Atsuya Miki, Takashi Kanamoto, Yoko Ikeda, Kazuhiko Mori, Aiko Iwase, Nobuyuki Shoji, Kenji Inoue, Junkichi Yamagami, Makoto Araie
PURPOSE: To construct and evaluate a Deep Learning (DL) model to diagnose early glaucoma from spectral domain optical coherence tomography (SD-OCT) images. DESIGN: AI diagnostic tool development, evaluation, and comparison METHODS: Setting: multiple institutional practices. STUDY POPULATION: Pre-training data consisted of 4316 OCT images (RS3000, Nidek) from 1565 eyes with open angle glaucoma (OAG) irrespective of the stage of glaucoma and 193 normal eyes...
October 11, 2018: American Journal of Ophthalmology
Natsume Suzuki, Takefumi Yamaguchi, Shinsuke Shibata, Toshihiro Nagai, Hisashi Noma, Kazuo Tsubota, Jun Shimazaki
PURPOSE: To investigate the association between the severity of bullous keratopathy and proinflammatory cytokine levels in the aqueous humor (AqH). DESIGN: Cross sectional study. METHODS: This study included a total of 95 eyes: 62 with bullous keratopathy and 33 that underwent cataract surgery. Central corneal thickness (CCT) and central corneal volume within 4mm and 6mm (CCV4mm and CCV6mm , respectively) were determined using anterior segment optical coherence tomography...
October 11, 2018: American Journal of Ophthalmology
Friederike Schaub, Fanny Gerber, Werner Adler, Philip Enders, Silvia Schrittenlocher, Ludwig M Heindl, Claus Cursiefen, Björn O Bachmann
PURPOSE: To investigate correlations between preoperative corneal backscatter with visual acuity results following Descemet Membrane Endothelial Keratoplasty (DMEK) in eyes with corneal endothelial disorders. DESIGN: Retrospective interventional case series. METHODS: The first 551 consecutive DMEKs of the Center of Ophthalmology, University of Cologne with available preoperative corneal densitometry values (corneal light backscatter measured in grey scale units) measured by Scheimpflug-based Oculus Pentacam corneal densitometry module were screened for eligibility...
October 10, 2018: American Journal of Ophthalmology
James J L Tee, Yesa Yang, Angelos Kalitzeos, Andrew Webster, James Bainbridge, Michel Michaelides
PURPOSE: Quantitative study of retinal structure, progression rates and interocular symmetry in RPGR-associated retinopathy using spectral domain optical coherence tomography (SD-OCT). DESIGN: Prospective, observational cohort study. METHODS: SETTING: Moorfields Eye Hospital, London, UK SUBJECTS: 38 subjects MAIN OUTCOME MEASURE: Two SD-OCT-derived ellipzoid zone (EZ) metrics with repeatability assessments. EZ width (EZW) measurements were made on transfoveal line scans...
October 9, 2018: American Journal of Ophthalmology
Tiffany A Chen, Ryan A Shields, Zachary H Bodnar, Natalia Callaway, Ira H Schachar, Darius M Moshfeghi
PURPOSE: To describe an improved understanding of the regression patterns following off-label intravitreal bevacizumab (IVB) treatment for retinopathy of prematurity (ROP). DESIGN: Retrospective cohort study. MethodsAll infants treated with IVB for Type 1 ROP at a single institution from June 2013 to March 2018 were retrospectively reviewed and the amount of retinal non-perfusion on fluorescein angiogram was calculated. ResultsOnly 3 eyes (3.3%) reached full vascular maturity in the 92 eyes of 46 patients analyzed...
October 9, 2018: American Journal of Ophthalmology
Reza Dana, John L Bradley, Annie Guerin, Irina Pivneva, Amber M Evans, Ipek Özer Stillman
PURPOSE: To assess the proportion of comorbidities in patients with dry eye disease (DED) compared with matched patients without DED in a comprehensive US population. DESIGN: Retrospective case-control study METHODS: Health care records for insurance claims data, detailing medical services incurred by military personnel, their families and dependents in military and civilian facilities across the United States from January 1, 2003 to March 31, 2015, were obtained from the Department of Defense (DOD) Military Health System (MHS)...
October 9, 2018: American Journal of Ophthalmology
F H Verhagen, E C A Stigter, M L Pras-Raves, B M T Burgering, S M Imhof, T R D J Radstake, J H de Boer, J J W Kuiper
PURPOSE: HLA-B27 positive acute anterior uveitis has a higher recurrence rate and shows more anterior chamber cell infiltration compared to HLA-B27-negative patients, suggesting distinct etiology of these clinically overlapping conditions. To advance our understanding of the biology of acute anterior uveitis, we characterized the metabolic profile of aqueous humor (AqH) of patients with HLA-B27 associated anterior uveitis (B27-AAU) and non-infectious idiopathic anterior uveitis (idiopathic AAU)...
October 9, 2018: American Journal of Ophthalmology
Alexandra P M de Koning-Backus, Gabriëlle H S Buitendijk, Jessica C Kiefte-de Jong, Johanna M Colijn, Albert Hofman, Johannes R Vingerling, Elizabeth B Haverkort, Oscar H Franco, Caroline C W Klaver
PURPOSE: What patients should eat to reduce their risk of age-related macular degeneration (AMD) is still unclear. We investigated the effect of a diet recommended by Health Councils on AMD. DESIGN: Prospective population-based cohort study. METHODS: 4202 participants from the Rotterdam Study aged 55+ years, free of AMD at baseline, were included and followed up for 9.1±5.8 years. Incident AMD was graded on fundus photographs. Dietary data were collected using a validated 170-item food frequency questionnaire, and food intakes were categorized into food patterns based on guidelines from Health Councils...
October 9, 2018: American Journal of Ophthalmology
Paul T Finger, Puneet Jain, Sri Krishna Mukkamala
PURPOSE: Evaluate Super-Thick Amniotic Membrane Graft(ST-AMG) for ocular surface reconstruction. DESIGN: Retrospective, interventional case series. METHODS: SETTING: Single center, clinical practice POPULATION: Selected patients with typically large ocular surface abnormalities that required reconstruction. INTERVENTION: Surgical insertion of ST-AMG for reconstruction or repair of the ocular surface. MAIN OUTCOME MEASURES: Intraoperative handling, graft position at 1 week post-implantation, graft dissolution at 3-weeks, epithelialization of the ocular surface and symblepharon...
October 9, 2018: American Journal of Ophthalmology
Ahnul Ha, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
No abstract text is available yet for this article.
October 8, 2018: American Journal of Ophthalmology
Hugo Y Hsu, Benjamin Ernst, Eric J Schmidt, Rohit Parihar, Chelsea Horwood, Sean L Edelstein
PURPOSE: To evaluate the laboratory results and prognostic factors of poor clinical outcomes in microbial keratitis cases over 15 years at Saint Louis University. DESIGN: Retrospective cohort and trend study. METHODS: Microbiological and clinical information from culture-positive cases seen at Saint Louis University from 1999-2013 were reviewed retrospectively. Statistical analyses were used to determine microbiological and antibiotic susceptibility trends...
October 8, 2018: American Journal of Ophthalmology
Mohamed F Farid
PURPOSE: to report the results of dual augmentation of vertical rectus muscle transposition (VRT) in the treatment of chronic sixth nerve palsy. DESIGN: retrospective case series. METHODS: this is a retrospective review of medical records of patients with chronic sixth nerve palsy who underwent dual augmented VRT with or without medial rectus (MR) recession from 2013 to 2016. Data collection included gender, age, laterality and duration of post operative follow up...
October 8, 2018: American Journal of Ophthalmology
Matthew R Starr, Wendy M Smith
PURPOSE: Histoplasmosis is a known complication of systemic immunosuppressive therapy, particularly among patients receiving tumor necrosis factor alpha (TNFα) inhibitors. There is limited data on the development of disseminated or pulmonary histoplasmosis among patients receiving systemic immunosuppressive medication for non-infectious ocular inflammation. DESIGN: Retrospective case series. METHODS: We reviewed all patients with uveitis or scleritis who subsequently developed pulmonary or disseminated histoplasmosis at the Mayo Clinic in Rochester, MN from September 1994 through July 1st , 2017 with a 3:1 age- and sex-matched control cohort who did not develop histoplasmosis...
October 8, 2018: American Journal of Ophthalmology
Reeta Danni, Claudia Taipale, Lotta Ilveskoski, Raimo Tuuminen
PURPOSE: To study the outcomes of uneventful cataract surgery in diabetic patients without retinal complications. SETTING: Conducted at Kymenlaakso Central Hospital, Kotka, Finland. DESIGN: A post-hoc treatment analysis using data from 2 double-blind RCTs. METHODS: A total of 276 eyes of 266 patients undergoing routine cataract surgery were included in the study. Patients with type I or II diabetes (N=56 eyes) were compared to non-diabetic patients (N=220 eyes)...
October 8, 2018: American Journal of Ophthalmology
Elodie Bousquet, Myriam Dhundass, Raphaël Lejoyeux, Ari Shinojima, Valérie Krivosic, Sarah Mrejen, Alain Gaudric, Ramin Tadayoni
PURPOSE: To assess the efficacy and safety of mineralocorticoid receptor antagonists (MRA) in the treatment of non-resolving central serous chorioretinopathy (CSC) and identify predictive factors of treatment response. DESIGN: Retrospective, multicenter, non-comparative, interventional case series. METHODS: Clinical and imaging data from consecutive patients with non-resolving CSC treated with eplerenone or spironolactone for 3-6 months between 2012 and 2016 were reviewed...
October 8, 2018: American Journal of Ophthalmology
Mariacristina Parravano, Daniele De Geronimo, Fabio Scarinci, Gianni Virgili, Lea Querques, Monica Varano, Francesco Bandello, Giuseppe Querques
PURPOSE: To investigate the progression of diabetic microaneurysms (MAs) according to the SD-OCT and OCT Angiography (OCTA) characteristics and to evaluate their influence on the retinal extracellular fluid accumulation at 1 year follow-up in patients with non proliferative diabetic retinopathy (NPDR). DESIGN: Prospective, observational case series. METHODS: Fourteen patients with NPDR underwent SD-OCT and OCTA at the baseline and at 1 year follow-up...
October 8, 2018: American Journal of Ophthalmology
R Doyle Stulting, Jonathan H Lass, Mark A Terry, Beth Ann Benetz, Nathan Cohen, Allison R Ayala, Maureen G Maguire, Christopher Croasdale, Yassine J Daoud, Steven P Dunn, Kenneth M Goins, Pankaj C Gupta, Marian S Macsai, Shahzad I Mian, Sudeep Pramanik, Jennifer Rose-Nussbaumer, Jonathan C Song, Walter J Stark, Alan Sugar, David D Verdier, Loretta B Szczotka-Flynn
PURPOSE: To identify factors related to graft rejection following Descemet stripping automated endothelial keratoplasty (DSAEK) in the Cornea Preservation Time Study (CPTS). DESIGN: Cohort study within a multicenter randomized clinical trial. METHODS: 1330 eyes of 1090 subjects undergoing DSAEK were randomized to receive a donor cornea with preservation time (PT) of 0-7 days (N=675) or 8-14 days (N=655) and followed for three years. Central endothelial cell density (ECD) was determined by a central image analysis reading center...
October 8, 2018: American Journal of Ophthalmology
Jiandong Pan, Ding Chen, Xiaoling Yang, Ruitao Zou, Kuo Zhao, Dan Cheng, Shenghai Huang, Tingye Zhou, Ye Yang, Feng Chen
No abstract text is available yet for this article.
October 6, 2018: American Journal of Ophthalmology
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