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American Journal of Ophthalmology

Robert M Feibel, Jennifer Arch
PURPOSE: This article reviews the history of Cuban Epidemic Optic Neuropathy (1991-1993), which caused visual loss, peripheral neuralgias, and other neurological symptoms in over 50,000 persons, an incidence of almost 0.5% of the entire population. The clinical findings, etiology, and treatment are described. We then relate the Cuban epidemic to the fictional epidemic of contagious blindness depicted by Nobel Laureate José Saramago in his 1995 novel Blindness. This novel describes an unnamed modern city in which all inhabitants, except the ophthalmologist's wife, are affected with a white, not black, blindness...
June 12, 2018: American Journal of Ophthalmology
Jialiang Zhao, Xiao Xu, Leon B Ellwein, Huaijin Guan, Mingguang He, Ping Liu, Jianhua Lv, Xunlun Sheng, Peizeng Yang, Jinglin Yi, Ning Cai, Mei Yang, Guangming Jin, Fei Leng, Fengrong Li, Yanping Li, Hong Lu, Wenqiang Shao, Shengfang Song, Yuansheng Yuan, Wenjuan Zhuang, Lei An
PURPOSE: Estimate surgical coverage of cataract-related vision impairment and blindness and visual acuity outcomes in operated eyes in rural China in 2014 with comparisons with the 2006 Nine-Province Survey. DESIGN: Population-based, cross-sectional study. METHODS: Geographical cluster sampling was used in randomly selecting residents from a rural county or semi-rural district within 9 provinces: Beijing, Jiangsu, Guangdong, Heilongjiang, Jiangxi, Hebei, Ningxia, Chongqing and Yunnan...
June 12, 2018: American Journal of Ophthalmology
Abhay R Vasavada, Vaishali Vasavada, Sajani K Shah, M R Praveen, Viraj A Vasavada, Rupal H Trivedi, Farida Rawat, Archana Koul
PURPOSE: Comparative evaluation of complications and visual outcomes following bilateral congenital cataract surgery in children upto 2 years of age with and without primary intraocular lens (IOL) implantation at 5 years follow-up DESIGN: Randomized, controlled, clinical trial METHODS: 60 children (120 eyes) upto 2 years of age undergoing bilateral congenital cataract surgery randomized to: group 1, primary aphakia (n=30) or group 2,primary IOL implantation (n=30). Single surgeon performed surgeries with identical surgical technique...
June 12, 2018: American Journal of Ophthalmology
Timur M Yildirim, Gerd U Auffarth, Grzegorz Łabuz, Silvia Bopp, Hyeck-Soo Son, Ramin Khoramnia
PURPOSE: Explanted hydrophilic intraocular lenses (IOLs) with clinically significant opacification after pars plana vitrectomy (PPV) were assessed for material change and optical quality, in an in-vitro laboratory study. DESIGN: Retrospective observational case series. METHODS: 10 opacified IOLs after PPV with intraocular gas injection were analyzed in a laboratory setting. Analyses included evaluation of patients' medical history, optical quality assessment, light microscopy, histological staining, scanning electron microscopy and energy dispersive X-Ray spectroscopy...
June 8, 2018: American Journal of Ophthalmology
Prafulla K Maharana, Pranita Sahay, Sagnik Sen, Renu Venugopal, Jeewan S Titiyal, Namrata Sharma
PURPOSE: To describe corneal ectasia in cases of chronic Steven Johnson Syndrome (SJS) DESIGN: Prospective observational study METHOD SETTING: Institutional PATIENT: Fifteen consecutive cases of chronic SJS MAIN OUTCOME MEASURES: Best corrected distance visual acuity (BCDVA), Kmax, anterior elevation, posterior elevation, thinnest pachymetry and Sotozono severity score RESULTS: 30 eyes of fifteen patients were included. Corneal tomography using Scheimpflug technology (Pentacam-HR, Oculus GmbH) was performed...
June 8, 2018: American Journal of Ophthalmology
Harris Sultan, Stacy V Smith, Andrew G Lee, Patricia Chévez-Barrios
PURPOSE: To provide quantitative evidence linking the Cluster of Differentiation-68 (CD68)+ macrophage-marker found on temporal artery biopsies (TABs) with disease prognosis. DESIGN: Retrospective, cross-sectional study METHODS: We examined 42 consecutive patients who had undergone unilateral TABs at a single hospital in 2015. Clinical data, laboratory data, and histopathologic features of TABs were recorded. INCLUSION CRITERIA: clinical diagnosis of giant cell arteritis (GCA) with TAB performed at the same center...
June 8, 2018: American Journal of Ophthalmology
Yoshikazu Ichikawa, Yutaka Imamura, Masahiro Ishida
PURPOSE: To examine correlations of inner nuclear layer (INL) thickness with metamorphosia and tangential retinal displacement in epiretinal membrane (ERM). DESIGN: Retrospective, consecutive, interventional case series. METHODS: SETTING: Institutional study PATIENT POPULATION: Fifty eyes of 50 patients undergoing epiretinal membrane surgery OBSERVATION PROCEDURES: M-CHARTS were used to measure metamorphopsia. Inner nuclear layer (INL) thickness and outer retinal layer (ORL) thickness in the macula and distances between the intersections of 2 sets of retinal vessels situated vertically or horizontally were measured in Spectralis OCT and infrared images...
June 8, 2018: American Journal of Ophthalmology
Etienne M Schönbach, Rupert W Strauss, Xiangrong Kong, Beatriz Muñoz, Mohamed A Ibrahim, Janet S Sunness, David G Birch, Gesa-Astrid Hahn, Fadi Nasser, Eberhart Zrenner, SriniVas R Sadda, Sheila K West, Hendrik P N Scholl
PURPOSE: To investigate the natural history of Stargardt disease (STGD1) using fixation location and fixation stability. DESIGN: Multicenter, international, prospective cohort study. METHODS: Fixation testing was performed using the Nidek MP-1 microperimeter as part of the prospective, multicenter, natural history study on the Progression of Stargardt disease (ProgStar). A total of 238 patients with ABCA4-related STGD1 were enrolled at baseline (bilateral enrollment in 86...
June 8, 2018: American Journal of Ophthalmology
Alexander D Blandford, Sari Yordi, Saloni Kapoor, Gabrielle Yeaney, Claudiu V Cotta, Jason Valent, Julian D Perry, Arun D Singh
PURPOSE: Ocular adnexal amyloidosis may represent localized manifestation of an underlying systemic process. Accurate identification of the amyloid fibrils can guide the systemic work up and treatment. The aim of this study was to characterize subtypes of ocular adnexal amyloidosis using immunohistochemistry and mass spectrometric analysis and to correlate with ocular involvement and systemic association. DESIGN: A retrospective case series. METHODS: Review of patients with ocular adnexal amyloidosis subtyped by immunohistochemistry and mass spectrometric analysis at the Cleveland Clinic from June 1995 to June 2017...
June 8, 2018: American Journal of Ophthalmology
Enrico Borrelli, Siva Balasubramanian, Giacinto Triolo, Piero Barboni, SriniVas R Sadda, Alfredo A Sadun
PURPOSE: To study the macular microvascular networks in patients affected by chronic Leber's hereditary optic neuropathy (LHON) using optical coherence tomography angiography (OCTA), and to quantify these changes in different macular sectors. DESIGN: Prospective cross-sectional study. METHODS: Patients with a clinical and molecularly confirmed diagnosis of LHON (affected patients in the chronic stage) were enrolled from the neuro-ophthalmology clinic at the Doheny-UCLA...
June 6, 2018: American Journal of Ophthalmology
Mali Okada, Rathika Kandasamy, Elaine W Chong, Myra McGuiness, Robyn H Guymer
PURPOSE: To assess outcomes of the treat-and-extend (T&E) injection regimen for neovascular age related macular degeneration (AMD) as compared to either a monthly or a pro-re-nata (PRN) treatment strategy. DESIGN: Systematic review and meta-analysis METHODS: Studies that compared the T&E regimen with either monthly or PRN dosing for treatment-naïve AMD were included. Trial eligibility, data extraction and risk of bias were assessed according to Cochrane review methods...
June 6, 2018: American Journal of Ophthalmology
Osama M Mustafa
No abstract text is available yet for this article.
June 5, 2018: American Journal of Ophthalmology
Swarup S Swaminathan, Pedro Monsalve, Xiao Yi Zhou, Mabel Enriquez-Algeciras, Sanjoy K Bhattacharya, Sander R Dubovy, Anna K Junk
PURPOSE: To determine whether there are identifiable, reproducible findings in the trabecular meshwork (TM) of patients with primary open-angle glaucoma (POAG) who underwent Kahook dual blade (KDB) goniotomy. DESIGN: Non-comparative retrospective case series. METHODS: Tertiary academic referral center, Veterans Affairs Medical Center. Thirteen patients (14 eyes) with POAG (100%) were treated with KDB goniotomy from May to December 2017. Isolated TM tissue was collected from 9 patients (10 eyes) and submitted for histologic analysis...
June 5, 2018: American Journal of Ophthalmology
Hae-Young Lopilly Park, Soo Ji Jeon, Chan Kee Park
PURPOSE: Optical coherence tomography angiography (OCT-A) was used to investigate the features of choroidal microcirculation within the β-zone peripapillary atrophy (PPA) and its association with visual field (VF) defects in myopic patients. DESIGN: A cross-sectional study. METHODS: Participants: Eighty-four myopic patients with a unilateral glaucomatous VF defect. OBSERVATION PROCEDURES: Comparison was performed between VF-affected eyes and contralateral normal eyes...
June 5, 2018: American Journal of Ophthalmology
Mae O Gordon, Michael A Kass
No abstract text is available yet for this article.
May 31, 2018: American Journal of Ophthalmology
Pia Leon, Mohit Parekh, Yoav Nahum, Michael Mimouni, Giuseppe Giannaccare, Laura Sapigni, Alessandro Ruzza, Massimo Busin
No abstract text is available yet for this article.
May 30, 2018: American Journal of Ophthalmology
Antoine Rousseau, Céline Terrada, Sara Touhami, Emmanuel Barreau, Pierre-Raphaël Rothschild, Sophie Valleix, Farida Benoudiba, Marie-Hélène Errera, Cécile Cauquil, Anne Guiochon-Mantel, David Adams, Marc Labetoulle
PURPOSE: To describe abnormalities in choroidal and retinal vasculature associated with Val30Met familial transthyretin amyloidosis (V30M-FTA) using fluorescein and indocyanine green (ICG) angiography. DESIGN: Prospective, cross-sectional study. METHODS: This study was conducted at the French National Reference Center for FTA. We included 18 consecutive genetically confirmed V30M-FTA patients (36 eyes) who underwent complete neurological examination, including staging with Polyneuropathy Disability (PND) score, and complete ophthalmic evaluation, including staging of intraocular amyloid deposits, fluorescein (FA) and ICG angiograms (ICG-A)...
May 30, 2018: American Journal of Ophthalmology
Mi Sun Sung, Hwan Heo, Sang Woo Park
PURPOSE: To evaluate the clinical characteristics of β-PPA in myopic eyes and determine whether the microstructure of β-PPA is associated with parapapillary microvasculature by using optical coherence tomography (OCT) angiography. DESIGN: Cross-sectional study METHODS: This study included 80 subjects with myopia with β-PPA. Spherical equivalent (SE) refractive error, axial length, horizontal tilt angle, and the width of β-PPA were evaluated. The microstructure of β-PPA and subfoveal choroidal thickness were evaluated using enhanced-depth imaging OCT and eyes were classified into 3 groups based on the presence of Bruch's membrane (BM), a PPA+BM only group, a PPA+BM and PPA-BM group, and a PPA-BM only group...
May 30, 2018: American Journal of Ophthalmology
Sebastian Siebelmann, Sebastian Lopez Ramos, Mario Matthaei, Paula Scholz, Silvia Schrittenlocher, Ludwig M Heindl, Björn Bachmann, Claus Cursiefen
No abstract text is available yet for this article.
May 29, 2018: American Journal of Ophthalmology
Emilio A Torres-Netto, Luzia Diegues Silva, Marco Antonio Bordon Riveros, Albert Santos, Luciene B Sousa, Lauro A Oliveira
PURPOSE: To evaluate microbiota colonizing soft contact lenses (CL) in eyes with Boston type I keratoprosthesis (BKPro), and determine the prevalence of resistance to fourth-generation fluoroquinolone (FQ). DESIGN: Prospective, observational study. SUBJECTS: Patients with BKPro using CL as routine who were in postoperative follow-up in the department of ophthalmology from Federal University of Sao Paulo, and volunteered to participate in the study...
May 29, 2018: American Journal of Ophthalmology
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