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American Journal of Ophthalmology

Christopher Bowd, Linda M Zangwill, Robert N Weinreb, Felipe A Medeiros, Akram Belghith
PURPOSE: "Floor effects" in retinal imaging are defined as the points at which no further structural loss can be detected. We estimated the measurement floors for spectral-domain optical coherence tomography (SD-OCT) measurements and compared global change over time in advanced glaucoma eyes. DESIGN: Validity study to investigate measurement floors. METHODS: A longitudinal "Variability Group" of 41 eyes with moderate to advanced glaucoma (SAP MD ≤ -8 dB) was used to estimate measurement floors...
November 30, 2016: American Journal of Ophthalmology
Namritha V Patrao, Sheelah Antao, Catherine Egan, Amer Omar, Robin Hamilton, Philip G Hykin, Sobha Sivaprasad, Ranjan Rajendram
No abstract text is available yet for this article.
November 30, 2016: American Journal of Ophthalmology
Pulak Agrawal
No abstract text is available yet for this article.
November 25, 2016: American Journal of Ophthalmology
Dan Călugăru, Mihai Călugăru
No abstract text is available yet for this article.
November 25, 2016: American Journal of Ophthalmology
Sotaro Ooto, Yoshimasa Kuroda, Nagahisa Yoshimura
No abstract text is available yet for this article.
November 25, 2016: American Journal of Ophthalmology
William J Ares, Daniel Tonetti, Jenny Y Yu, Edward A Monaco, John C Flickinger, L Dade Lunsford
PURPOSE: Uveal metastases are ophthalmologic tumors that have historically been treated by fractionated external beam radiation therapy or invasive brachytherapy. The need for rapid response and less invasive management options led the authors to explore the use of Gamma knife stereotactic radiosurgery (SRS) for this common problem. DESIGN: Interventional case series. METHODS: Intervention: In order to prevent eye movement during the procedure, all three patients underwent a retrobulbar anesthetic block followed by magnetic resonance imaging to detect the target...
November 23, 2016: American Journal of Ophthalmology
Roberto dell'Omo, Gianni Virgili, Stanislao Rizzo, Serena De Turris, Giovanni Coclite, Dario Giorgio, Ermanno dell'Omo, Ciro Costagliola
PURPOSE: To compare the morphologic and functional characteristics and response to surgery of lamellar macular holes (LMHs) with and without lamellar hole-associated epiretinal proliferation (LHEP) and standard epiretinal membrane (ERM). DESIGN: Retrospective observational case series. METHODS: Setting: Vitreoretinal clinical practice. STUDY POPULATION: Eigthy-four eyes of 84 patients. The included eyes must present an irregular foveal contour and schitic or cavitated lamellar separation of neurosensory retina on spectral-domain optical coherence tomography (SD-OCT) and an area of increased autofluorescence on blue- fundus autofluorescence (B-FAF)...
November 23, 2016: American Journal of Ophthalmology
Nicolas A Yannuzzi, Nancy Si, Nidhi Relhan, Ajay E Kuriyan, Thomas A Albini, Audina M Berrocal, Janet L Davis, William E Smiddy, Justin Townsend, Darlene Miller, Harry W Flynn
PURPOSE: To report the clinical features, causative organisms, and visual acuity (VA) outcomes associated with acute-onset endophthalmitis after clear corneal cataract surgery over the past two decades. DESIGN: Retrospective case series. METHODS: Clinical and microbiology records were reviewed for 63 eyes of 63 patients who presented to a tertiary referral center between 2006 and 2015 with culture-positive endophthalmitis occurring within 6 weeks of clear corneal cataract surgery...
November 23, 2016: American Journal of Ophthalmology
Nazlee Zebardast, David S Friedman, Susan Vitale
PURPOSE: Estimate prevalence of presenting near-vision impairment (PNVI) among people =50years in the United States (US) and examine associations with socio-demographic characteristics. DESIGN: Cross-sectional study METHODS: 11016 of 12781 (88.5%) US adults =50 years participated in the National Health and Nutrition Examination Survey (NHANES) between 1999-2008 with recorded near visual acuity. PNVI was defined as presenting near-vision worse than 20/40; functional near-vision impairment (FNVI) was defined as at least "moderate-difficulty" with either reading newsprint or near-work...
November 16, 2016: American Journal of Ophthalmology
Karen B Schaal, Giovanni Gregori, Philip J Rosenfeld
PURPOSE: To determine if en face optical coherence tomography (OCT) imaging can identify nascent geographic atrophy (nGA) in eyes with intermediate age-related macular degeneration (iAMD). DESIGN: Retrospective observational case series. METHODS: Patients with iAMD from the COMPLETE study at the Bascom Palmer Eye Institute were evaluated to determine if nGA was present at baseline and at follow-up using high density Spectralis OCT B-scans and en face OCT images from the Cirrus OCT instrument...
November 15, 2016: American Journal of Ophthalmology
Ryo Asaoka, Kazunori Hirasawa, Aiko Iwase, Yuri Fujino, Hiroshi Murata, Nobuyuki Shoji, Makoto Araie
PURPOSE: To validate the usefulness of the 'Random Forests' classifier to diagnose early glaucoma with spectral domain optical coherence tomography (SD-OCT). METHOD: Design: Comparison of diagnostic algorithms Setting: multiple institutional practice STUDY PARTICIPANTS: Training dataset included 94 eyes of 94 open angle glaucoma (OAG) patients and 84 eyes of 84 normal subjects and testing dataset included 114 eyes of 114 OAG patients and 82 eyes of 82 normal subjects...
November 8, 2016: American Journal of Ophthalmology
Donald L Budenz, Julia Beiser Huecker, Steven J Gedde, Mae Gordon, Michael Kass
PURPOSE: To determine the cumulative incidence of optic disc hemorrhage (ODH) before and after development of primary open angle glaucoma (POAG); determine the prognostic significance of ODH for the development of POAG; identify predictive factors for ODH. DESIGN: Prospective cohort study. METHODS: ODHs were evaluated in 3,236 eyes of 1618 Ocular Hypertension Treatment Study (OHTS) participants annually using stereoscopic optic disc photographs...
November 7, 2016: American Journal of Ophthalmology
Swathi Kaliki, Faraz Ali Mohammad, Prerana Tahiliani, Virender S Sangwan
PURPOSE: To compare the surgical outcomes of ocular surface squamous neoplasia (OSSN) following wide excisional biopsy with and without primary simple limbal epithelial transplantation (p-SLET). DESIGN: Non-randomized clinical study with historical controls METHODS: Setting: Single-institutional study PATIENTS: 8 patients who underwent wide excisional biopsy of OSSN without p-SLET (historical controls) and 7 patients with p-SLET (cases) INTERVENTION: Wide excisional biopsy, p-SLET MAIN OUTCOME MEASURES: Limbal stem cell deficiency (LSCD) RESULTS: The tumor features between cases versus historical controls including mean number of limbal clock hours affected by OSSN (6 vs 4; p=0...
November 7, 2016: American Journal of Ophthalmology
Lindsay A Rhodes, Carrie E Huisingh, Adam E Quinn, Gerald McGwin, Frank LaRussa, Daniel Box, Cynthia Owsley, Christopher A Girkin
PURPOSE: To examine if racial differences in Bruch's membrane opening-minimum rim width (BMO-MRW) in spectral domain optical coherence tomography (SDOCT) exist, specifically between people of African descent (AD) and European descent (ED) in normal ocular health. DESIGN: Cross-sectional study METHODS: Patients presenting for a comprehensive eye exam at retail-based primary eye clinics were enrolled based on ≥1 of the following at-risk criteria for glaucoma: AD aged ≥ 40 years, ED aged ≥50 years, diabetes, family history of glaucoma, and/or pre-existing diagnosis of glaucoma...
November 5, 2016: American Journal of Ophthalmology
Virender Sachdeva, Sushma Katukuri, Ramesh Kekunnaya, Merle Fernandes, Mohammed Hasnat Ali
INTRODUCTION: Initial undercorrection of intra-ocular lens (IOL power) is a common practice in children undergoing pediatric cataract surgery. However, long term refractive status of these children is largely unknown. The purpose of this study is to analyze the long-term refractive status of these children. DESIGN: Retrospective observational study METHODS: We analyzed records of children (< 7 yrs) who underwent cataract surgery where a primary IOL implantation was performed and had completed follow-up upto atleast 7 years of age...
November 3, 2016: American Journal of Ophthalmology
Steven L Mansberger, Shivali Menda, Brad Fortune, Stuart K Gardiner, Shaban Demirel
PURPOSE: To characterize the error of optical coherence tomography (OCT) measurements of retinal nerve fiber layer (RNFL) thickness when using automated retinal layer segmentation algorithms without manual refinement. DESIGN: cross-sectional study METHODS: Setting: glaucoma clinical practice. STUDY POPULATION: 3490 scans from 412 eyes of 213 individuals with a diagnosis of glaucoma or glaucoma suspect. Observational Procedures: We used spectral domain OCT (Spectralis, Heidelberg Engineering, Heidelberg, Germany) to measure RNFL thickness in a 6-degree peripapillary circle, and exported the native 'automated segmentation only' results...
November 3, 2016: American Journal of Ophthalmology
Ryan S Kim, Patricia Chevez-Barrios, Maria E Bretana, Tien P Wong, Bin S Teh, Amy C Schefler
PURPOSE: Perform the first in vivo examination of fine needle aspiration biopsy scleral tracts to determine the incidence of iatrogenic extension of tumor cells. DESIGN: A prospective, consecutive, observational case series. METHODS: Setting: Clinical/surgical setting at Retina Consultants of Houston and Houston Methodist Hospital, Houston, TX. PARTICIPANTS: Ten patients who were scheduled for enucleation as primary treatment for uveal melanoma...
November 3, 2016: American Journal of Ophthalmology
Min Li, Ye Yang, Hong Jiang, Giovanni Gregori, Luiz Roisman, Fang Zheng, Bilian Ke, Dongyi Qu, Jianhua Wang
PURPOSE: To investigate the changes of the retinal microvascular network and microcirculation in high myopia. DESIGN: A cross-sectional, matched, comparative clinical study. PARTICIPANTS: Twenty eyes of twenty subjects with non-pathological high myopia (28 ± 5 Years) with a refractive error of -6.31 ± 1.23 Diopters (mean ± standard deviation) and twenty eyes of twenty age- and gender-matched control subjects (30 ± 6 years) with a refractive error of -1...
November 3, 2016: American Journal of Ophthalmology
Christophe Chiquet, Florent Aptel, Catherine Creuzot-Garcher, Jean-Paul Berrod, Laurent Kodjikian, Pascale Massin, Catherine Deloche, Julien Perino, Bridget-Anne Kirwan, Sophie de Brouwer, Jean-Marc Combette, Francine Behar-Cohen
PURPOSE: To evaluate the efficacy and safety of XG-102 (brimapitide) compared to dexamethasone eye-drops in the treatment of post-operative ocular inflammation. DESIGN: Multicenter, randomized, parallel group, double-masked, non-inferiority clinical trial PATIENTS: Patients who underwent anterior and posterior segments combined surgery, or glaucoma surgery, or complex posterior segment surgery, were eligible to participate. INTERVENTION: Patients were administered a single sub-conjunctival injection of 250 μl XG-102 90 μg (N=47) or 900 μg (N=48) or placebo (N=50) at the end of ocular surgery...
October 31, 2016: American Journal of Ophthalmology
Peter L Nesper, Brian T Soetikno, Amani A Fawzi
PURPOSE: To study choriocapillaris blood flow in age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA) and study its correlation to vision (VA) in eyes with reticular pseudodrusen (RPD) versus those with drusen without RPD (drusen). DESIGN: Cross-sectional study METHODS: Patients with either drusen or RPD in early AMD underwent OCTA imaging of the superior, inferior, and/or nasal macula. We quantified "percent choriocapillaris area of non-perfusion" (PCAN) in eyes with RPD versus those with drusen...
October 26, 2016: American Journal of Ophthalmology
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