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American Journal of Obstetrics and Gynecology

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https://www.readbyqxmd.com/read/30639383/expanding-the-indications-for-cell-free-dna-in-the-maternal-circulation-clinical-considerations-and-implications
#1
REVIEW
Gian Carlo di Renzo, Jose' Luis Bartha, Catia M Bilardo
Non-invasive prenatal testing (NIPT) for fetal aneuploidy using cell-free DNA has been widely integrated into routine obstetrical care. The scope of cfDNA testing has expanded from trisomies 21, 18, and 13 to include sex chromosome conditions, panels of specific microdeletions, and more recently genome-wide copy number variants and rare autosomal trisomies. Because the technical ability to test for a condition does not necessarily correspond with a clinical benefit to a population or to individual pregnant women, the benefits and harms of screening programs must be carefully weighed before implementation...
January 10, 2019: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30639089/effect-of-postoperative-partial-bladder-filling-after-minimally-invasive-hysterectomy-on-post-anesthesia-care-unit-discharge-and-cost-a-single-blinded-randomized-controlled-trial
#2
Gaby Moawad, Paul Tyan, Cherie Marfori, Elias Abi Khalil, Daniel Park
BACKGROUND: Hysterectomy is one of the most common surgical procedures performed each year with substantial related healthcare costs. This trial studied the effect of postoperative bladder backfilling to sub-micturition level in the operating room and its effect on early postoperative patient care and related cost. OBJECTIVE: To compare the effect of bladder backfilling on early postoperative patient care and related cost. STUDY DESIGN: A randomized, single-blinded, controlled trial conducted between April 2016 and February 2017 at a single urban university hospital providing tertiary care for minimally invasive gynecologic surgery...
January 9, 2019: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30633920/association-between-gestational-age-and-severe-maternal-morbidity-and-mortality-of-preterm-cesarean-delivery-a-population-based-cohort-study
#3
Julie Blanc, Noémie Resseguier, François Goffinet, Elsa Lorthe, Gilles Kayem, Pierre Delorme, Christophe Vayssiere, Pascal Auquier, Claude D'ercole
BACKGROUND: Cesarean delivery rates at extreme prematurity have regularly increased over the last years and few previous studies investigated severe maternal morbidity of extreme preterm cesarean. OBJECTIVE: To evaluate if gestational age < 26 weeks of gestation (weeks) is associated with severe maternal morbidity and mortality (SMMM) of preterm cesarean in comparison with cesarean between 26 and 34 weeks. STUDY DESIGN: The "Etude Epidémiologique sur les petits âges gestationnels" (EPIPAGE) 2 is a national prospective population-based cohort study of preterm births in 2011...
January 8, 2019: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30633919/time-from-neuraxial-anesthesia-placement-to-delivery-is-inversely-proportional-to-umbilical-arterial-cord-ph-at-scheduled-cesarean-delivery
#4
Rebecca R Rimsza, William M Perez, Shilpa Babbar, Megan O'Brien, Laura K Vricella
BACKGROUND: Neuraxial block-related hypotension and maternal obesity contribute to uterine hypoperfusion and decreased umbilical arterial pH at cesarean delivery. Between the time of anesthesia placement and delivery, the fetus may be exposed to a hypo-perfused uterine environment without surgeon awareness of fetal compromise. OBJECTIVE: We sought to evaluate neonatal umbilical arterial pH according to pre-delivery time intervals at scheduled term cesarean. STUDY DESIGN: We performed a retrospective cohort study of cesarean deliveries between September 2014 and February 2017...
January 8, 2019: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30633918/diagnostic-performance-of-third-trimester-ultrasound-for-the-prediction-of-late-onset-fetal-growth-restriction-a-systematic-review-and-meta-analysis
#5
REVIEW
Javier Caradeux, Raigam J Martinez-Portilla, Anna Peguero, Alexandros Sotiriadis, Francesc Figueras
OBJECTIVE: To establish the diagnostic performance of ultrasound screening for predicting late smallness for gestational age (SGA) and/or fetal growth restriction (FGR). DATA SOURCES: A systematic search was performed to identify relevant studies published since 2007 in English, Spanish, French, Italian, or German, using the databases PubMed, ISI Web of Science, and SCOPUS. STUDY ELIGIBILITY CRITERIA: Prospective and retrospective cohort studies in low-risk or non-selected singleton pregnancies with screening ultrasound performed at ≥32 weeks of gestation...
January 8, 2019: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30633917/vaginal-assessment-and-expedited-amniotomy-in-oral-misoprostol-labor-induction-in-nulliparas-a-randomized-trial
#6
Sandar Tin Win, Peng Chiong Tan, Imelda Balchin, Su Yen Khong, Khaing Si Lay, Siti Zawiah Omar
BACKGROUND: Labor is induced in 20-30% of maternities with an increasing trend of use. Labor induction with oral misoprostol is associated with reduced risk of Cesarean births and has a comparable safety and effectiveness profile to mechanical method like with the Foley catheter. Labor induction in nulliparous women continues to be challenging with the process often quite protracted and eventual Cesarean rate is high and particularly so when the cervix is unfavorable and ripening is required...
January 8, 2019: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30633916/resolution-of-intra-amniotic-sludge-after-antibiotic-administration-in-a-patient-with-short-cervix-and-recurrent-mid-trimester-loss
#7
Cheryl Dinglas, Martin Chavez, Anthony Vintzileos
No abstract text is available yet for this article.
January 8, 2019: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30629909/academic-physicians-as-factory-workers-identifying-and-preventing-alienation-of-labor
#8
Frank A Chervenak, Laurence B McCullough
Recent changes in the culture of academic obstetrics and gynecology have increased the potential for disconnect between physicians and their patients. These changes include increased emphasis on productivity, burgeoning bureaucracies for purposes of compliance, arbitrary clinical goals such as low cesarean delivery rates, the electronic medical record, and lack of respect. These changes are predatory on professionalism when they alienate obstetrician-gynecologists from their patients. The concepts of alienated labor and non-alienated labor in the political philosophy of Karl Marx can be used to explain this alienation...
January 7, 2019: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30629908/two-dose-versus-single-dose-of-methotrexate-for-treatment-of-ectopic-pregnancy-a-meta-analysis
#9
REVIEW
Snigdha Alur-Gupta, Laura G Cooney, Suneeta Senapati, Mary D Sammel, Kurt T Barnhart
OBJECTIVE: To compare the treatment success and failure rates, as well as side effects and surgery rates between methotrexate protocols. DATA SOURCES: PubMed, Embase and the Cochrane library searched up till July 2018. STUDY ELIGIBILITY CRITERIA: RCTs that compared women with ectopic pregnancies receiving the single dose, two dose or multi-dose methotrexate protocols. STUDY APPRAISAL AND SYNTHESIS METHODS: Odds of treatment success, treatment failure, side effects and surgery for tubal rupture as well as length of follow-up until treatment success compared using random and fixed effects meta-analysis...
January 7, 2019: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30625296/the-american-gynecological-and-obstetrical-society-reinvigorating-for-the-21st-century
#10
Laurel W Rice, Charles J Lockwood, Maureen Phipps, John O L Delancey, Ronald D Alvarez, Marcelle I Cedars
The American Gynecological and Obstetrical Society (AGOS) has the potential to serve as a unifying organization to advocate for women's reproductive health care, education and research. This report reviews a strategic plan designed to reinvigorate AGOS to address, together with our partner organizations, the ever more pressing issues and challenges in women's reproductive health.
January 6, 2019: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30625295/clinical-diagnosis-of-endometriosis-a-call-to-action
#11
Sanjay K Agarwal, Charles Chapron, Linda C Giudice, Marc R Laufer, Nicholas Leyland, Stacey A Missmer, Sukhbir S Singh, Hugh S Taylor
Endometriosis can have a profound impact on women's lives, including associated pain, infertility, decreased quality of life, and interference with daily life, relationships, and livelihood. The first step in alleviating these adverse sequelae is to diagnose the underlying condition. For many women, the journey to endometriosis diagnosis is long and fraught with barriers and misdiagnoses. Inherent challenges include a gold standard based on an invasive surgical procedure (laparoscopy) and diverse symptomatology, contributing to the well-established delay of 4 to 11 years from first symptom onset to surgical diagnosis...
January 6, 2019: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30625294/alobar-holoprosencephaly-detected-in-a-nine-week-embryo
#12
Simon Meagher, Lisa Hui
No abstract text is available yet for this article.
January 6, 2019: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30594567/computerized-analysis-of-cardiotocograms-and-st-signals-is-associated-with-significant-reductions-in-hypoxic-ischemic-encephalopathy-and-cesarean-delivery-an-observational-study-in-38-466-deliveries
#13
Joana Lopes-Pereira, Antónia Costa, Diogo Ayres-de-Campos, Cristina Costa-Santos, Joana Amaral, João Bernardes
BACKGROUND: Intrapartum cardiotocography (CTG) is widely used in high-resource countries and remains at the centre of fetal monitoring and the decision to intervene, but there is ample evidence of poor reliability in visual interpretation, as well as limited accuracy in identifying fetal hypoxia. Combined monitoring of CTG and ST segment signals was developed to increase specificity, but analysis relies heavily on CTG interpretation and is therefore also affected by the previously referred problems...
December 27, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30594566/in-reply-are-early-screening-biomarkers-for-endometrial-cancer-needed-to-reduce-health-disparities
#14
LETTER
Kemi M Doll, Barbara A Goff, Scott D Ramsey
No abstract text is available yet for this article.
December 27, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30594565/are-early-screening-biomarkers-for-endometrial-cancer-needed-to-reduce-health-disparities
#15
LETTER
Marina R S Walther-Antonio, Andrea Mariani
No abstract text is available yet for this article.
December 27, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30593768/red-plaques-and-tumors-on-the-vulva
#16
Chao Wu
No abstract text is available yet for this article.
December 26, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30586548/revitalizing-research-in-genitourinary-syndrome-of-menopause
#17
Olivia H Chang, Marie Fidela R Paraiso
Genitourinary syndrome of menopause is defined as the collection of signs and symptoms of the genitourinary tract from menopause, previously known as vulvovaginal atrophy. The Food and Drug Administration (FDA) has approved select hormonal and non-hormonal treatment for vaginal atrophy, including systemic estrogen, vaginal estrogen, estrogen receptor modulators and dehydroepiandrosterone. These medications can increase the risk of thromboembolic disease and malignancy; furthermore, the cost of the medications have been increasing...
December 23, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30582928/magnetic-resonance-imaging-for-prenatal-estimation-of-birth-weight-in-pregnancy-review-of-available-data-techniques-and-future-perspectives
#18
REVIEW
Caroline Kadji, Mieke M Cannie, Serena Resta, David Guez, Fouad Abi Khalil, Riccardo De Angelis, Jacques C Jani
Fetuses at the extremes of growth abnormalities carry a risk of perinatal morbidity and mortality. Their identification is traditionally done by 2-dimensional ultrasound, the performance of which is not always optimal. Magnetic resonance imaging (MRI) superbly depicts fetal anatomy and anomalies and has largely contributed to the evaluation of high-risk pregnancies. In 1994, Baker et al. introduced MRI for estimation of fetal weight (EFW). This is done by measuring the fetal body volume (FBV) and converting it through a formula to fetal weight...
December 21, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30582927/survival-outcome-prediction-in-cervical-cancer-cox-models-versus-deep-learning-model
#19
Koji Matsuo, Sanjay Purushotham, Bo Jiang, Rachel S Mandelbaum, Tsuyoshi Takiuchi, Yan Liu, Lynda D Roman
BACKGROUND: Historically, the Cox proportional hazard regression (CPH) model has been the mainstay for survival analyses in oncologic research. The CPH model is generally utilized based upon an assumption of linear association. However, it is likely that in reality there are many clinico-pathological features that exhibit a non-linear association in biomedicine. OBJECTIVE: To compare the deep-learning neural network model and the CPH model in the prediction of survival in women with cervical cancer...
December 21, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30579877/reply
#20
LETTER
Alexander M Friedman
No abstract text is available yet for this article.
December 20, 2018: American Journal of Obstetrics and Gynecology
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