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American Journal of Obstetrics and Gynecology

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https://www.readbyqxmd.com/read/28646647/successful-maintenance-of-key-physiological-parameters-in-preterm-lambs-treated-with-ex%C3%A2-vivo-uterine-environment-therapy-for-a-period-of-1-week
#1
Haruo Usuda, Shimpei Watanabe, Yuichiro Miura, Masatoshi Saito, Gabrielle C Musk, Judith Rittenschober-Böhm, Hideyuki Ikeda, Shinichi Sato, Takushi Hanita, Tadashi Matsuda, Alan H Jobe, John P Newnham, Sarah J Stock, Matthew W Kemp
BACKGROUND: Extremely preterm infants born at the border of viability (22-24 weeks' gestation) have high rates of death and lasting disability. Ex vivo uterine environment therapy is an experimental neonatal intensive care strategy that provides gas exchange using parallel membranous oxygenators connected to the umbilical vessels, sparing the extremely preterm cardiopulmonary system from ventilation-derived injury. OBJECTIVE: In this study, we aimed to refine our ex vivo uterine environment therapy platform to eliminate fetal infection and inflammation, while simultaneously extending the duration of hemodynamically stable ex vivo uterine environment therapy to 1 week...
June 20, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28645573/evidence-that-fetal-death-is-associated-with-placental-aging
#2
Kaushik Maiti, Zakia Sultana, Robert John Aitken, Jonathan Morris, Felicity Park, Bronwyn Andrew, Simon C Riley, Roger Smith
BACKGROUND: The risk of unexplained fetal death or stillbirth increases late in pregnancy suggesting that placental aging is an etiological factor. Aging is associated with oxidative damage to DNA, RNA and lipids. We hypothesized that placentas at more than 41 completed weeks of gestation (late-term) would show changes consistent with aging that would also be present in placentas associated with stillbirths. OBJECTIVE: We sought to determine whether placentas from late-term pregnancies and unexplained stillbirth show oxidative damage and other biochemical signs of aging...
June 20, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28645572/longitudinal-associations-between-mental-health-conditions-and-overactive-bladder-in-women-veterans
#3
Catherine S Bradley, Ingrid E Nygaard, Stephen L Hillis, James C Torner, Anne G Sadler
BACKGROUND: One in five recently deployed U.S. women veterans report overactive bladder symptoms. Mental health conditions such as depression and anxiety commonly co-occur in women with overactive bladder, but temporal relationships between these outcomes have not been well-studied, and the mechanism behind this association is unknown. The Women Veterans Urinary Health Study, a nationwide longitudinal study in recently deployed women veterans, was designed to better understand relationships between overactive bladder and mental health conditions...
June 20, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28599895/variations-in-resting-energy-expenditure-impact-on-gestational-weight%C3%A2-gain
#4
Ek Berggren, P O'Tierney-Ginn, S Lewis, L Presley, S Hauguel De-Mouzon, P M Catalano
BACKGROUND: There are significant variations in gestational weight gain, with many women gaining in excess of the Institute of Medicine guidelines. Unfortunately, efforts to improve appropriate gestational weight gain have had only limited success. To date, interventions have focused primarily on decreasing energy intake and/or increasing physical activity. Maternal resting energy expenditure, which comprises ∼60% of total energy expenditure compared with the ∼20% that comes from physical activity, may be an important consideration in understanding variations in gestational weight gain...
June 17, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28619692/a-randomized-trial-of-motivational-interviewing-and-facilitated-contraceptive-access-to-prevent-rapid-repeat-pregnancy-among-adolescent-mothers
#5
Jack Stevens, Robyn Lutz, Ngozi Osuagwu, Dana Rotz, Brian Goesling
BACKGROUND: Most interventions designed to reduce teen pregnancy rates have not focused on pregnant and/or parenting adolescents. Therefore, a large randomized controlled trial was conducted regarding a motivational interviewing program entitled Teen Options to Prevent Pregnancy in a low income sample of adolescent mothers. This program recommended monthly sessions between a participant and a registered nurse over 18 months. This program also featured facilitated birth control access through transportation assistance and a part-time contraceptive clinic...
June 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28619691/a-mouse-model-of-antepartum-stillbirth
#6
Anum Rahman, Lindsay S Cahill, Yu-Qing Zhou, Johnathan Hoggarth, Monique Y Rennie, Mike Seed, Christopher K Macgowan, John C Kingdom, S Lee Adamson, John G Sled
BACKGROUND: Many stillbirths of normally-formed fetuses in the third trimester could be prevented via delivery if reliable means to anticipate this outcome existed. However, since the etiology of these stillbirths is often unexplained and, although the underlying mechanism is presumed to be hypoxia from "placental insufficiency", the placentas often appear normal on histopathologic examination. Gestational age is a risk factor for antepartum stillbirth, with a rapid rise in stillbirth rates after 40 weeks gestation...
June 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28619690/metformin-the-aspirin-of-the-21-st-century-its-role-in-gestational-diabetes-prevention-of-preeclampsia-and-cancer-and-the-promotion-of-longevity
#7
REVIEW
Roberto Romero, Offer Erez, Maik Hüttemann, Eli Maymon, Bogdan Panaitescu, Agustin Conde-Agudelo, Percy Pacora, Bo Hyun Yoon, Lawrence I Grossman
Metformin is everywhere. Originally introduced in clinical practice as an anti-diabetic agent, its role as a therapeutic agent is expanding to include treatment of pre-diabetes, gestational diabetes, polycystic ovarian disease, and more recently, experimental studies, as well as observations in randomized clinical trials, suggest that metformin could have a place in the treatment or prevention of preeclampsia. This article provides a brief overview of the history of metformin in the treatment of diabetes, reviews the results of meta-analyses of metformin in gestational diabetes, and the treatment of obese non-diabetic pregnant women to prevent macrosomia...
June 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28619689/risks-and-benefits-of-opportunistic-salpingectomy-during-vaginal-hysterectomy-a-decision-analysis
#8
Lauren A Cadish, Jonathan P Shepherd, Emma L Barber, Beri Ridgeway
BACKGROUND: Fallopian tubes are commonly removed during laparoscopic and open hysterectomy to prevent ovarian and tubal cancer, but are not routinely removed during vaginal hysterectomy due to perceptions of increased morbidity, difficulty, or inadequate surgical training. OBJECTIVE: We sought to quantify complications and costs associated with a strategy of planned salpingectomy during vaginal hysterectomy. STUDY DESIGN: We created a decision analysis model using TreeAgePro...
June 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28619688/single-port-laparoscopy-in-gynecologic-oncology-seven-years-of-experience-at-a-single-institution
#9
Laura Moulton, Amelia M Jernigan, Caitlin Carr, Lindsey Freeman, Pedro F Escobar, Chad M Michener
BACKGROUND: Single port laparoscopy has gained popularity within minimally invasive gynecologic surgery for its feasibility, cosmetic outcomes and safety. However, within gynecologic oncology, there is limited data regarding short-term adverse outcomes and long term hernia risk in patients undergoing single port laparoscopic surgery. OBJECTIVE: To describe short-term outcomes and hernia rates in patients after single port laparoscopy in a gynecologic oncology practice...
June 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28610900/persistence-of-fimbrial-tissue-on-the-ovarian-surface-following-salpingectomy
#10
Carmen Gan, Rashna Chenoy, Dhivya Chandrasekaran, Elly Brockbank, Antony Hollingworth, Sotiris Vimplis, Alexandra C Lawrence, Arjun R Jeyarajah, David Oram, Nandita Deo, Jamna Saravanamuthu, Sarah S Lam, Asma Faruqi, Naveena Singh, Ranjit Manchanda
BACKGROUND: Salpingectomy is recommended as a risk-reducing strategy for epithelial tubo-ovarian cancer. The gold standard procedure is complete tubal excision. OBJECTIVE: To assess the presence of residual fimbrial/tubal tissue on ovarian surfaces following salpingectomy. DESIGN: Prospective analysis of patients undergoing salpingo-oophorectomy +/- hysterectomy for benign indications, early cervical cancer or low risk endometrial cancer at a UK National Health Service Trust...
June 10, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28610899/reproductive-rights-advocacy-not-just-for-the-family-planning-community
#11
Cara C Heuser, Karen J Gibbins, Marcela C Smid, D Ware Branch
Women and families benefit from access to the full spectrum of reproductive care, including family planning services. We commend our family planning colleagues on their tireless dedication to preserve the rights of women through advocacy. While several of our perinatology peers have also set an example by dedication to these issues, advocacy for patient access to reproductive care options has not been a focus of the larger perinatology community. The time has come for individual perinatologists, as well as the overall perinatology community, to join them and do the work needed to preserve access to safe care, including contraception and abortion services...
June 10, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28610898/immediate-versus-delayed-postpartum-use-of-levonorgestrel-contraceptive-implants-a-randomized-controlled-trial-in-uganda
#12
Sarah Averbach, Othman Kakaire, Herbert Kayiga, Felicia Lester, Abby Sokoloff, Josaphat Byamugisha, Christine Dehlendorf, Jody Steinauer
BACKGROUND: Use of long acting highly-effective contraception has the potential to improve women's ability to avoid short interpregnancy intervals, which are associated with an increased risk of maternal morbidity and mortality, and preterm delivery. In Uganda, contraceptive implants are not routinely available during the immediate postpartum period. OBJECTIVE: The purpose of this study was to compare the proportion of women using levonorgestrel contraceptive implants at six months after delivery in women randomized to immediate or delayed insertion...
June 10, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28602773/frequency-and-consequences-of-ventricular-hypertrophy-in-pregnant-women-with-treated-chronic-hypertension
#13
Anne M Ambia, Jamie L Morgan, Karen L Wilson, Scott W Roberts, C Edward Wells, Donald D Mcintire, Monika Sanghavi, David B Nelson, F Gary Cunningham
BACKGROUND: Ventricular hypertrophy is a known sequelae of long-standing chronic hypertension with associated morbidity and mortality. OBJECTIVE: To assess the frequency and importance of left ventricular hypertrophy in women treated for chronic hypertension during pregnancy. STUDY DESIGN: This was a retrospective study of pregnant women with chronic hypertension who were delivered at our hospital from January 2009 to February 2015. All women who were given antihypertensive therapy underwent maternal echocardiography and were managed in a dedicated, high-risk prenatal clinic...
June 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28602772/urine-leakage-during-sexual-activity-among-ethnically-diverse-community-dwelling-middle-aged-and-older-women
#14
Nagambika Munaganuru, Stephen K van den Eeden, Jennifer Creasman, Leslee L Subak, Lisa Strano-Paul, Alison J Huang
BACKGROUND: Urinary incontinence is associated with decreased female sexual function, but little is known about the prevalence, predictors, and impact of urine leakage during sexual activity among women in the community. OBJECTIVE: To evaluate the prevalence and impact of urine leakage during sex in ethnically-diverse, community-dwelling midlife and older women. STUDY DESIGN: Urinary incontinence and sexual function were assessed by structured questionnaire in a multi-ethnic, community-based cohort of women enrolled in Kaiser Permanente Northern California, an integrated healthcare delivery system in California...
June 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28602771/the-prevalence-of-active-tuberculosis-infection-among-pregnant-women-is-not-increasing-in-the-united-states
#15
LETTER
Jason L Salemi, Hamisu M Salihu
No abstract text is available yet for this article.
June 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28602770/reply-to-letter-l17-052ar1
#16
LETTER
Haim Arie Abenhaim, Amira El-Messidi, Andrea R Spence
No abstract text is available yet for this article.
June 8, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28601567/impact-of-evidence-based-interventions-on-wound-complications-after-cesarean
#17
Lorene A Temming, Nandini Raghuraman, Ebony B Carter, Molly J Stout, Roxane M Rampersad, George A Macones, Alison G Cahill, Methodius G Tuuli
BACKGROUND: A number of evidence-based interventions have been proposed to reduce post cesarean wound complications. Examples of such interventions include appropriate timing of preoperative antibiotics, appropriate choice of skin antisepsis, closure of the subcutaneous layer if subcutaneous depth is ≥ 2 cm, and subcuticular skin closure with suture rather than staples. However, the collective impact of these measures is unclear. OBJECTIVE: We sought to estimate the impact of a group of evidence-based surgical measures (prophylactic antibiotics administered prior to skin incision, chlorhexidine-alcohol for skin antisepsis, closure of subcutaneous layer, and subcuticular skin closure with suture) on wound complications after cesarean, and to estimate residual risk factors for wound complications...
June 7, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28599900/clinicopathologic-and-molecular-markers-in-cervical-carcinoma-a-prospective-cohort-study
#18
Mari Kyllesø Halle, Akinyemi I Ojesina, Hilde Engerud, Kathrine Woie, Ingvild Løberg Tangen, Frederik Holst, Erling Høivik, Kanthida Kusonmano, Ingfrid S Haldorsen, Olav K Vintermyr, Jone Trovik, Bjørn I Bertelsen, Helga B Salvesen, Camilla Krakstad
BACKGROUND: Cervical cancer is a major health problem worldwide. Identification of effective clinicopathologic and molecular markers is vital to improve treatment stratification. OBJECTIVES: To validate a set of well-defined clinicopathologic features in a large population based, prospectively collected cervical cancer cohort to support their use in the clinic. Further, we explore p53 and HER2 as potential prognostic markers in cervical cancer. STUDY DESIGN: Tissue was collected from 401 cervical cancer patients...
June 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28599899/the-placenta-accreta-spectrum-pathophysiology-and-evidence-based-anatomy-for-prenatal-ultrasound-imaging
#19
REVIEW
Eric Jauniaux, Sally Collins, Graham J Burton
The placenta accreta spectrum (PAS) is a complex obstetric complication associated with a high maternal morbidity. It is a relatively new disorder of placentation, and is the consequence of damage to the endometrium-myometrial interface of the uterine wall. When first described 80 years ago, it mainly occurred after manual removal of the placenta, uterine curettage or endometritis. Superficial damage leads primarily to an abnormally adherent placenta, and is diagnosed as the complete or partial absence of the decidua on histology...
June 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28599898/a-randomized-open-label-controlled-trial-of-chlorhexidine-alcohol-versus-povidone-iodine-for-cesarean-antisepsis-the-capica-trial
#20
Edward H Springel, Xiao-Yu Wang, Vanessa M Sarfoh, Bradley P Stetzer, Steven A Weight, Brian M Mercer
BACKGROUND: Identification of optimal surgical site antisepsis preparations may reduce cesarean-related surgical site infections. Two recently published investigations examined efficacy of chlorhexidine-alcohol and iodine-alcohol preparations. No previous randomized controlled trial has compared chlorhexidine-alcohol to povidone-iodine aqueous scrub and paint in reduction of cesarean-related surgical site infection. OBJECTIVE: The purpose of the study was to determine if chlorhexidine-alcohol would result in less surgical site infections than povidone-iodine when used as skin antisepsis preparation prior to cesarean delivery...
June 6, 2017: American Journal of Obstetrics and Gynecology
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