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American Journal of Clinical Pathology

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https://www.readbyqxmd.com/read/28165529/molecular-biomarkers-for-the-evaluation-of-colorectal-cancer
#1
Antonia R Sepulveda, Stanley R Hamilton, Carmen J Allegra, Wayne Grody, Allison M Cushman-Vokoun, William K Funkhouser, Scott E Kopetz, Christopher Lieu, Noralane M Lindor, Bruce D Minsky, Federico A Monzon, Daniel J Sargent, Veena M Singh, Joseph Willis, Jennifer Clark, Carol Colasacco, R Bryan Rumble, Robyn Temple-Smolkin, Christina B Ventura, Jan A Nowak
No abstract text is available yet for this article.
February 3, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28158445/the-impact-of-an-electronic-ordering-system-on-blood-bank-specimen-rejection-rates
#2
Stefanie K Forest, Maryam Shirazi, Charlotte Wu-Gall, Brie A Stotler
No abstract text is available yet for this article.
January 31, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28158394/challenges-to-classic-esophageal-candidiasis
#3
Mohammed I Alsomali, Michael A Arnold, Wendy L Frankel, Rondell P Graham, Phil A Hart, Dora M Lam-Himlin, Bita V Naini, Lysandra Voltaggio, Christina A Arnold
No abstract text is available yet for this article.
January 31, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28122722/improving-global-access-to-diagnostic-testing-more-steps-forward
#4
EDITORIAL
Michael L Wilson, Kenneth A Fleming
No abstract text is available yet for this article.
January 25, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28122725/optimal-fixation-conditions-and-dna-extraction-methods-for-mlpa-analysis-on-ffpe-tissue-derived-dna
#5
Lilit Atanesyan, Maryvonne J Steenkamer, Anja Horstman, Cathy B Moelans, Jan P Schouten, Suvi P Savola
OBJECTIVES: Molecular genetic analysis of formalin-fixed, paraffin-embedded (FFPE) tissues is of great importance both for research and diagnostics. Multiplex ligation-dependent probe amplification (MLPA) is a widely used technique for gene copy number determination, and it has been successfully used for FFPE tissue-extracted DNA analysis. However, there have been no studies addressing the effect of tissue fixation procedures and DNA extraction methods on MLPA. This study therefore focuses on selecting optimal preanalytic conditions such as FFPE tissue preparation conditions and DNA extraction methods...
January 24, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28122724/lab-in-a-box-a-guide-to-building-anatomic-pathology-networks-in-resource-limited-settings
#6
REVIEW
Laura C Warner
OBJECTIVES: Noncommunicable diseases, including malignancies, represent an increasing proportion of the global human disease burden, but low- and middle-income countries lack the necessary infrastructure to diagnose and treat the rising number of patients with cancer. METHODS: African Strategies for Advancing Pathology devised the lab-in-a-box to guide rapid deployment of anatomic pathologic services in sub-Saharan Africa. RESULTS: This framework defines essential elements of a laboratory network, providing the full spectrum of cancer care, and explores the many barriers to creating fully functional laboratory networks in resource-limited settings...
January 24, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28122723/male-breast-cancer-a-single-institution-clinicopathologic-and-immunohistochemical-study
#7
Kate M Serdy, José Pablo Leone, David J Dabbs, Rohit Bhargava
OBJECTIVES: A clinicopathologic study with an emphasis on tumor immunohistochemical profile is presented. METHODS: Sixty-one cases of male invasive breast cancers were studied. Median age of the cohort was 65 years. RESULTS: Ninety-seven percent were estrogen receptor positive+ and 10% human epidermal growth factor receptor 2 positive. The individual diagnostic marker positivity was 98% for GATA-binding protein 3, 95% for androgen receptor, 90% for progesterone receptor, 88% for deleted in pancreatic cancer 4, 75% for gross cystic disease fluid protein 15, 72% for cytokeratin 7, 55% for mammaglobin, and 15% for vimentin and Wilms tumor protein 1...
January 24, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28110280/her2-gene-protein-assay-is-useful-to-determine-her2-status-and-evaluate-her2-heterogeneity-in-her2-equivocal-breast-cancer
#8
Yanjun Hou, Hiroaki Nitta, Zaibo Li
OBJECTIVES: Approximately 15% of breast cancers show equivocal human epidermal growth factor receptor 2 (HER2) results on HER2 immunohistochemistry (IHC) and are reflexed for fluorescence in situ hybridization (FISH). However, some cases remain equivocal. In this study, we evaluated these double-equivocal cases by using a novel gene protein assay (GPA), which can simultaneously assess HER2 gene copy number and protein on a single slide using bright-field microscopy. METHODS: GPA was performed on 42 HER2 IHC and FISH double-equivocal cases...
January 21, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28108472/relapsed-acute-promyelocytic-leukemia-lacks-classic-leukemic-promyelocyte-morphology-and-can-create-diagnostic-challenges
#9
Vanessa J Dayton, Robert W McKenna, Sophia L Yohe, Michelle M Dolan, Elizabeth Courville, Harold Alvarez, Michael A Linden
OBJECTIVES: Although current therapies for acute promyelocytic leukemia (APL), such as all-trans retinoic acid and arsenic trioxide, usually result in remission, some patients relapse. Early recognition of relapse is critical for prompt intervention. In this study, we systematically reviewed morphologic, immunophenotypic, and cytogenetic findings in paired diagnostic and relapsed APL cases and describe and quantify the changes in blast morphology at relapse. METHODS: By electronic database search, we identified eight paired diagnostic and relapsed APL cases for which peripheral blood or bone marrow smears were available for review...
January 20, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28108471/prognostic-significance-of-residual-acute-myeloid-leukemia-in-bone-marrow-samples-taken-prior-to-allogeneic-hematopoietic-cell-transplantation
#10
Alexandra E Kovach, Andrew M Brunner, Amir T Fathi, Yi-Bin Chen, Robert P Hasserjian
OBJECTIVES: We sought to identify features in routine evaluation of pre-hematopoietic cell transplantation (HCT) bone marrow samples from patients with acute myeloid leukemia (AML) that influenced patient outcome. METHODS: Of 140 patients, evidence of residual leukemia (RL) was identified in 38 (27%) of pre-HCT samples, as defined by 5% or more aspirate blasts, increased blood blasts, clustered or necrotic blasts on biopsy specimens, and/or leukemia-associated karyotypic abnormalities...
January 20, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28028117/standard-operating-procedure-utilization-for-tuberculosis-microscopy-in-mekelle-city-north-ethiopia
#11
Yemane Weldu, Hagos Gebru, Getahun Kahsay, Gebremichael Teweldemedhn, Yifter Hagos, Amlsha Kahsay
OBJECTIVES: The aim of this study was to assess the utilization of standard operating procedures for acid-fast bacilli (AFB) smear microscopy. METHODS: A facility-based cross-sectional study was conducted in select health institutions in Mekelle City, Ethiopia, from July 1, 2015, through August 30, 2015. Using a simple random sampling technique, 18 health facilities were included in the study. Data were collected using a standard checklist and entered into Epi Info version 3...
December 27, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28028115/epidemiologic-analysis-of-respiratory-viral-infections-mainly-in-hospitalized-children-and-adults-in-a-midwest-university-medical-center-after-the-implementation-of-a-14-virus-multiplex-nucleic-acid-amplification-test
#12
Sophie Arbefeville, Patricia Ferrieri
OBJECTIVES: To investigate the etiology of viral respiratory tract infections mainly in hospitalized children and adults over a 12-month consecutive period after implementation of a 14-virus multiplex nucleic acid amplification test. METHODS: From January 2014 to January 2015, a total of 2,237 respiratory samples were analyzed with the US Food and Drug Administration-cleared eSensor Respiratory Viral Panel (GenMark Diagnostics, Carlsbad, CA). RESULTS: Of the 2,237 specimens tested, 788 specimens were positive for at least one virus, giving a positivity rate of 35...
December 27, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28007703/immunohistochemistry-is-rarely-justified-for-the-diagnosis-of-viral-infections
#13
Isaac H Solomon, Jason L Hornick, Alvaro C Laga
OBJECTIVES: To determine the utility of immunohistochemistry (IHC) for the diagnosis of viral infections in surgical pathology specimens lacking characteristic viral cytopathic effects. METHODS: Five years of cases at an academic medical center were reviewed for the use of IHC to detect cytomegalovirus (CMV), herpes simplex virus 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), adenovirus, or polyomavirus (ie, BK or JC). RESULTS: In total, 1,636 viral IHC stains were ordered on 1,099 specimens from 957 cases...
December 21, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28007702/immunohistochemical-detection-of-ros1-fusion
#14
Yuhua Su, Theodore Goncalves, Dora Dias-Santagata, Mai P Hoang
OBJECTIVES: Patients whose tumors harbor ROS1 translocation may benefit from targeted therapy. Detection of ROS1 rearrangement can be done by three methods: immunohistochemistry, fluorescence in situ hybridization, and molecular assays. Immunohistochemistry would be a cost-effective means to screen for ROS1 translocation, which is uncommon. METHODS: ROS1 immunostain was performed on cases with known ROS1 translocation status detected either by fluorescence in situ hybridization or next-generation sequencing...
December 21, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28171939/lab-in-a-box
#15
Laura C Warner
No abstract text is available yet for this article.
January 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28171911/improving-global-access-to-diagnostic-testing
#16
Michael L Wilson, Kenneth A Fleming
No abstract text is available yet for this article.
January 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28171879/male-breast-cancer
#17
Kate M Serdy, José Pablo Leone, David J Dabbs, Rohit Bhargava
No abstract text is available yet for this article.
January 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28158414/an-essential-pathology-package-for-low-and-middle-income-countries
#18
Kenneth A Fleming, Mahendra Naidoo, Michael Wilson, John Flanigan, Susan Horton, Modupe Kuti, Lai Meng Looi, Chris Price, Kun Ru, Abdul Ghafur, Jianxiang Wang, Nestor Lago
No abstract text is available yet for this article.
January 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28077401/acknowledgments
#19
(no author information available yet)
No abstract text is available yet for this article.
December 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28077400/differential-expression-of-hedgehog-and-snail-in-cutaneous-fibrosing-disorders-implications-for-targeted-inhibition
#20
Amrita Goyal, Katy R Linskey, Jonathan Kay, Lyn M Duncan, Rosalynn M Nazarian
OBJECTIVES: To examine Hedgehog signaling in cutaneous fibrosing disorders for which effective approved therapies are lacking, expand our knowledge of pathophysiology, and explore the rationale for targeted inhibition. METHODS: Stain intensity and percentage of cells staining for Sonic hedgehog (Shh), Indian hedgehog (Ihh), Patched (Ptch), glycogen synthase kinase 3 β (GSK3-β), β-catenin, and Snail were evaluated in human skin biopsy specimens of keloid, hypertrophic scar (Hscar), scleroderma, nephrogenic systemic fibrosis (NSF), scar, and normal skin using a tissue microarray...
December 2016: American Journal of Clinical Pathology
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