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Allergy

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https://www.readbyqxmd.com/read/29337345/sputum-cytology-during-late-phase-responses-to-inhalation-challenge-with-different-allergens
#1
Joana A Revez, Kieran J Killian, Paul M O'Byrne, Louis-Philippe Boulet, John W Upham, Gail M Gauvreau, Manuel A R Ferreira
BACKGROUND: In mouse models of allergic asthma, exposure to different allergens can trigger distinct inflammatory subtypes in the airways. We investigated if this observation extends to humans. METHODS: We compared the frequency of sputum inflammatory subtypes between mild allergic asthma subjects (n=129) exposed to different allergens in inhalation challenge tests. These tests were performed using a standardized protocol as part of clinical trials of experimental treatments for asthma, prior to drug randomization...
January 16, 2018: Allergy
https://www.readbyqxmd.com/read/29336489/executive-summary-methods-and-evidence-report-for-the-evidence-and-consensus-based-s3-guideline-for-the-definition-classification-diagnosis-and-management-of-urticaria-revision-and-update-2017
#2
LETTER
C Dressler, S Rosumeck, R N Werner, M Magerl, M Metz, M Maurer, A Nast, T Zuberbier
For the revision and update of the EAACI/GA²LEN/EDF/WAO guideline on urticaria we defined and followed a structured process as recommended by national and international guideline development manuals (1) and took the Appraisal of Guidelines Research and Evaluation (AGREE II) Instrument (2) into account. The full methods report can be found in the online appendix [please add link]. This article is protected by copyright. All rights reserved.
January 16, 2018: Allergy
https://www.readbyqxmd.com/read/29336067/treatment-of-allergic-rhinitis-using-mobile-technology-with-real-world-data-the-mask-observational-pilot-study
#3
REVIEW
J Bousquet, S Arnavielhe, A Bedbrook, G Alexis-Alexandre, M van Eerd, R Murray, G W Canonica, M Illario, E Menditto, G Passalacqua, C Stellato, M Triggiani, P Carreiro-Martins, J Fonseca, M Morais Almeida, L Nogueira-Silva, A M Pereira, A Todo Bom, I Bosse, D Caimmi, P Demoly, P Devillier, J F Fontaine, J Just, G L Onorato, M L Kowalski, P Kuna, B Samolinski, J M Anto, J Mullol, A Valero, P V Tomazic, K C Bergmann, T Keil, L Klimek, R Mösgues, S Shamai, T Zuberbier, E Murphy, Peter McDowall, D Price, D Ryan, A Sheikh, N H Chavannes, W J Fokkens, V Kvedariene, A Valiulis, C Bachert, P W Hellings, I Kull, E Melén, M Wickman, C Bindslev-Jensen, E Eller, T Haahtela, E Valovirta, N G Papadopoulos, I Annesi-Maesano, M Bewick, S Bosnic-Anticevich, A A Cruz, G De Vries, B Gemicioglu, D Larenas-Linnemann, D Laune, E Mathieu-Dupas, R E O'Hehir, F Portejoie, V Siroux, O Spranger, O VandenPlas, A Yorgancioglu
BACKGROUND: Large observational implementation studies are needed to triangulate the findings from randomized control trials (RCTs) as they reflect "real world" everyday practice. In a pilot study, we attempted to provide additional and complementary insights on the real life treatment of allergic rhinitis using mobile technology. METHODS: A mobile phone app (Allergy Diary, freely available Google Play and Apple App stores) collects the data of daily visual analogue scales (VAS) for (i) overall allergic symptoms, (ii) nasal, ocular and asthma symptoms, (iii) work, as well as (iv) medication use using a treatment scroll list including all medications (prescribed and over the counter (OTC)) for rhinitis customized for 15 countries...
January 15, 2018: Allergy
https://www.readbyqxmd.com/read/29336054/the-eaaci-ga%C3%A2-len-edf-wao-guideline-for-the-definition-classification-diagnosis-and-management-of-urticaria-the-2017-revision-and-update
#4
T Zuberbier, W Aberer, R Asero, A H Abdul Latiff, D Baker, B Ballmer-Weber, J A Bernstein, C Bindslev-Jensen, Z Brzoza, R Buense Bedrikow, G W Canonica, M K Church, T Craig, I V Danilycheva, C Dressler, L F Ensina, A Giménez-Arnau, K Godse, M Gonçalo, C Grattan, J Hebert, M Hide, A Kaplan, A Kapp, C H Katelaris, E Kocatürk, K Kulthanan, D Larenas-Linnemann, T A Leslie, M Magerl, P Mathelier-Fusade, R Y Meshkova, M Metz, A Nast, E Nettis, H Oude-Elberink, S Rosumeck, S S Saini, M Sánchez-Borges, P Schmid-Grendelmeier, P Staubach, G Sussman, E Toubi, G A Vena, C Vestergaard, B Wedi, R N Werner, Z Zhao, M Maurer
This evidence and consensus-based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on December 1st, 2016. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the EU-founded network of excellence, the Global Allergy and Asthma European Network (GA²LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) with the participation of 48 delegates of 42 national and international societies...
January 15, 2018: Allergy
https://www.readbyqxmd.com/read/29331087/outdoor-pollen-is-a-trigger-of-child-and-adolescent-asthma-ed-presentations-a-systematic-review-and-meta-analysis
#5
REVIEW
Bircan Erbas, Mitra Jazayeri, Katrina A Lambert, Constance H Katelaris, Luke A Prendergast, Rachel Tham, M Jeannette Parrodi, Janet Davies, Ed Newbigin, Michael J Abramson, Shyamali C Dharmage
BACKGROUND: In the context of increased asthma exacerbations associated with climatic changes such as thunderstorm asthma, interest in establishing the link between pollen exposure and asthma hospital admissions has intensified. Here, we systematically reviewed and performed a meta-analysis of studies on pollen and ED attendance. METHODS: A search for studies with appropriate search strategy in Medline, Embase, Web of Science and CINAHL was conducted. Each study was assessed for quality and risk of bias...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29331070/how-does-dose-impact-on-the-severity-of-food-induced-allergic-reactions-and-can-this-improve-risk-assessment-for-allergenic-foods
#6
REVIEW
Anthony E J Dubois, Paul J Turner, Jonathan Hourihane, Barbara Ballmer-Weber, Kirsten Beyer, Chan Chun-Han, M Hazel Gowland, Sue O'Hagan, Lynne Regent, Ben Remington, Sabine Schnadt, Thomas Stroheker, René W R Crevel
Quantitative risk assessment for food allergens has made considerable progress in recent years, yet acceptability of its outcomes remains stymied because of the limited extent to which it has been possible to incorporate severity as a variable. Reaction severity, particularly following accidental exposure, depends on multiple factors, related to the allergen, the host and any treatments which might be administered. Some of these factors are plausibly still unknown. Quantitative risk assessment shows that limiting exposure through control of dose reduces the rates of reactions in allergic populations, but its impact on the relative frequency of severe reactions at different doses is unclear...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29331046/prevalence-severity-and-risk-factors-for-acute-exacerbations-of-nasal-and-sinus-symptoms-by-chronic-rhinosinusitis-status
#7
Jordan R Kuiper, Annemarie G Hirsch, Karen Bandeen-Roche, Agnes S Sundaresan, Bruce K Tan, Robert P Schleimer, Robert C Kern, Walter F Stewart, Brian S Schwartz
BACKGROUND: Nasal and sinus symptoms (NSS) are common to many health conditions, including chronic rhinosinusitis (CRS). Few studies have investigated the occurrence and severity of, and risk factors for, acute exacerbations of NSS (AENSS) by CRS status (current, past, or never met European Position Paper on Rhinosinusitis [EPOS] criteria for CRS). METHODS: Four seasonal questionnaires were mailed to a stratified random sample of Geisinger primary care patients...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29331045/the-urgent-need-for-a-harmonized-severity-scoring-system-for-acute-allergic-reactions
#8
Antonella Muraro, Montserrat Fernandez-Rivas, Kirsten Beyer, Victòria Cardona, Andrew Clark, Esben Eller, Jonathan O'B Hourihane, Marek Jutel, Aziz Sheikh, Ioana Agache, Katrina J Allen, Liz Angier, Barbara Ballmer-Weber, Maria Beatrice Bilò, Carsten Bindslev-Jensen, Carlos A Camargo, Antonella Cianferoni, Audrey DunnGalvin, Philippe A Eigenmann, Susanne Halken, Karin Hoffmann-Sommergruber, Susanne Lau, Caroline Nilsson, Lars K Poulsen, Franziska Rueff, Jonathan Spergel, Gunter Sturm, Frans Timmermans, Maria J Torres, Paul Turner, Ronald van Ree, Magnus Wickman, Margitta Worm, E N Clare Mills, Graham Roberts
The accurate assessment and communication of the severity of acute allergic reactions is important to patients, clinicians, researchers, the food industry, public health and regulatory authorities. Severity has different meanings to different stakeholders with patients and clinicians rating the significance of particular symptoms very differently. Many severity scoring systems have been generated, most focusing on the severity of reactions following exposure to a limited group of allergens. They are heterogeneous in format, none has used an accepted developmental approach and none has been validated...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29331029/characterization-of-cd34-hematopoietic-cells-in-systemic-mastocytosis-potential-role-in-disease-dissemination
#9
Andrea Mayado, Cristina Teodosio, Noelia Dasilva Freire, Maria Jara-Acevedo, Andrés C Garcia-Montero, Ivan Álvarez-Twose, Laura Sánchez-Muñoz, Almudena Matito, Carolina Caldas, Javier I Muñoz-González, Ana Henriques, José I Sánchez-Gallego, Luis Escribano, Alberto Orfao
BACKGROUND: Recent studies show that most systemic mastocytosis (SM) patients, including indolent SM (ISM) with (ISMs+) and without skin lesions (ISMs-), carry the KIT D816V mutation in PB leukocytes. We investigated the potential association between the degree of involvement of BM hematopoiesis by the KIT D816V mutation and the distribution of different maturation-associated compartments of bone marrow (BM) and peripheral blood (PB) CD34+ hematopoietic precursors (HPC) in ISM, and identified the specific PB cell compartments that carry this mutation...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29331026/the-asthma-rhinitis-multimorbidity-is-associated-with-ige-polysensitization-in-adolescents-and-adults
#10
Valérie Siroux, Natalia Ballardini, Marion Soler, Christian Lupinek, Anne Boudier, Isabelle Pin, Jocelyne Just, Rachel Nadif, Josep M Anto, Erik Melen, Rudolf Valenta, Magnus Wickman, Jean Bousquet
BACKGROUND: Children with multimorbid asthma and rhinitis show IgE polysensitization to several allergen sources. This association remain poorly studied in adolescents and adults using defined allergen molecules. We investigated IgE sensitization patterns towards a broad panel of aeroallergen components in adults and adolescents with a focus on individuals with asthma and rhinitis multimorbidity. METHODS: IgE reactivity to 64 microarrayed aeroallergen molecules was determined with the MeDALL-chip in samples from the French EGEA study (n=840, age=40...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29331025/multidimensional-endotypes-of-chronic-rhinosinusitis-and-their-association-with-treatment-outcomes
#11
Bo Liao, Jin-Xin Liu, Zhi-Yong Li, Zhen Zhen, Ping-Ping Cao, Yin Yao, Xiao-Bo Long, Heng Wang, Yan Wang, Robert Schleimer, Zheng Liu
BACKGROUND: The expression of chronic rhinosinusitis (CRS) is multidimensional. Disease heterogeneity in patients with CRS remains poorly understood. This study aimed to identify endotypes of CRS using cluster analysis by integrating multidimensional characteristics and to explore their association with treatment outcomes. METHODS: A total of 28 clinical variables and 39 mucosal cellular and molecular variables were analyzed using principal component analysis. Cluster analysis was performed on 246 prospectively recruited Chinese CRS patients with at least one-year post-operative follow-up...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29330864/allergy-committed-to-progress-in-allergy-and-immunology
#12
Hans-Uwe Simon, Thomas Bieber
After more than 8 years, our terms as Co-Editors-in-Chief have now reached an end. We are thankful for having had the privilege to serve the community in this position. We think that we have reached our original goal of increasing the overall quality of the journal (1). The science which is reported every month in Allergy is of high quality and wide interest, largely contributing to the development of the fields of Allergy and Immunology. The impact of the journal is high, as reflected by its present impact factor of 7...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29322523/prevalence-of-pollen-induced-allergic-rhinitis-with-high-pollen-exposure-in-grasslands-of-northern-china
#13
Xue-Yan Wang, Ting-Ting Ma, Xiao-Yan Wang, Yan Zhuang, Xiang-Dong Wang, Hui-Yu Ning, Hai-Yun Shi, Rui-Li Yu, Dan Yan, Hong-Dong Huang, Yong-Fei Bai, Guang-Liang Shan, Biao Zhang, Qing-Kun Song, Yan-Fen Zhang, Tie-Jun Zhang, Da-Zhong Jia, Xi-Long Liu, Zhen-Xiang Kang, Wei-Jun Yan, Ba-Te Yang, Xiu-Zhi Bao, Shu-Hua Sun, Fang-Fang Zhang, Wen-Hui Yu, Chao-Lu Bai, Tang Wei, Tong Yang, Tao-Qiong Ma, Xue-Bin Wu, Jian-Guo Liu, Hui Du, Luo Zhang, Yong Yan, De-Yun Wang
BACKGROUND: The aim of this study was to investigate the prevalence of epidemiologic and physician-diagnosed pollen-induced AR (PiAR) in the grasslands of northern China, and to study the impact of the intensity and time of pollen exposure on PiAR prevalence. METHODS: A multistage, clustered and proportionately stratified random sampling with a field-interviewer administrated survey study was performed together with skin prick tests (SPT) and measurements of the daily pollen count...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29322510/lolium-perenne-peptide-immunotherapy-is-well-tolerated-and-elicits-a-protective-b-cell-response-in-seasonal-allergic-rhinitis-patients
#14
R Mösges, A F Koch, E Raskopf, J Singh, K Shah-Hosseini, B Hauswald, Y Yarin, F Corazza, L Haazen, S Pirotton, S Allekotte, G Zadoyan, T Legon, S R Durham, M H Shamji
BACKGROUND: Systemic allergic reactions are a risk for allergen immunotherapy that utilizes intact allergen preparations. We evaluated the safety, efficacy and immune mechanisms of short-course treatment with adjuvant-free Lolium perenne peptides (LPP) following a 6-week dose-escalation protocol. METHODS: In a prospective, dose-escalation study, 61 grass pollen-allergic patients received 2 subcutaneous injections of LPP once weekly for 6 weeks. Safety was assessed evaluating local reactions, systemic reactions and adverse events...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29319899/usefulness-of-asthma-predictive-index-in-ascertaining-asthma-status-of-children-using-medical-records-an-explorative-study
#15
Chung-Il Wi, Elizabeth A Krusemark, Gretchen Voge, Sunghwan Sohn, Hongfang Liu, Euijung Ryu, Miguel A Park, Jose A Castro-Rodriguez, Young J Juhn
BACKGROUND: Frequent wheezing in original Asthma Predictive Index (API) was defined by parental report of recurrent wheezing within 1 year during the first 3 years of life. The nature of frequent wheezing in children, particularly aged over 3 years has not been studied. We aimed to assess the frequency and interval of wheezing to define frequent wheezing in ascertaining asthma for children using medical records. METHODS: Among children who participated in a previous study (n=427), all wheezing episodes documented in medical records were collected for children who had ≥2wheezing episodes PLUS met one major criteria or two minor criteria of API...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29319896/skin-inflammation-exacerbates-food-allergy-symptoms-in-epicutaneously-sensitized-mice
#16
Akiko Kawasaki, Naohiro Ito, Hiroki Murai, Motoko Yasutomi, Hironobu Naiki, Yusei Ohshima
BACKGROUND: Cutaneous exposure to food antigen through impaired skin barrier has been shown to induce epicutaneous sensitization, thereby causing IgE-mediated food allergies. OBJECTIVE: We examined whether skin barrier impairment following epicutaneous sensitization exacerbates food allergies. METHODS: BALB/c mice were epicutaneously sensitized by repeated application of ovalbumin (OVA) to MC903-pretreated ear skin for 48 hours weekly and then intragastrically challenged with OVA...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29319887/depressed-mood-is-associated-with-loss-of-productivity-in-allergic-rhinitis
#17
Adam P Campbell, Lloyd P Hoehle, Katie M Phillips, David S Caradonna, Stacey T Gray, Ahmad R Sedaghat
Allergic rhinitis (AR) is associated with significant decreases in quality of life and productivity losses. We hypothesized that symptoms of AR may differentially associate with lost productivity due to AR. We performed a cross-sectional cohort study of 105 prospectively recruited patients with persistent AR. AR control, severity of depressed mood and sinonasal symptoms were assessed with the Rhinitis Control Assessment Test (RCAT), Patient Health Questionnaire (PHQ-2), and the 22-item Sinonasal Outcome Test (SNOT-22) respectively...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29319886/eaaci-guidelines-on-allergen-immunotherapy-out-with-the-old-and-in-with-the-new
#18
EDITORIAL
Ioana Agache
Occurring in both developed and developing countries and across all ethnic groups and ages allergic diseases represent a global health problem. During the last few decades, there has been an increase in the prevalence of allergic diseases and it has been predicted that by 2025 half of the entire EU population will be affected [1]. The three major management strategies are avoidance, symptom control by pharmacotherapy and allergen immunotherapy (AIT). By contrast with symptom control by pharmacotherapy AIT aims to modify the immune system via tolerance induction [2] and is potentially able to alter the course of allergic diseases [3]...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29319884/similar-localization-of-conformational-ige-epitopes-on-the-house-dust-mite-allergens-der-p-5-and-der-p-21-despite-limited-ige-cross-reactivity
#19
M Curin, T Garmatiuk, Y Resch-Marat, K W Chen, G Hofer, K Fauland, W Keller, W Hemmer, S Vrtala, M Focke-Tejkl, R Valenta
BACKGROUND: Due to high IgE recognition frequency and high allergenic activity, Der p 5 and Der p 21 are clinically important house dust mite (HDM) allergens. The objective of this study was to characterise the immunodominant IgE epitopes of Der p 5 and Der p 21 responsible for their high allergenic activity. METHODS: A panel of 12 overlapping peptides spanning the Der p 5 and Der p 21 sequence were synthesized to search for sequential IgE epitopes by direct testing for allergic patients ' IgE reactivity...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29319882/oral-myeloid-cells-uptake-allergoids-coupled-to-mannan-driving-th1-treg-responses-upon-sublingual-delivery-in-mice
#20
Irene Soria, Juan López-Relaño, Marcos Viñuela, José-Ignacio Tudela, Alba Angelina, Cristina Benito-Villalvilla, Carmen M Díez-Rivero, Bárbara Cases, Ana I Manzano, Enrique Fernández-Caldas, Miguel Casanovas, Oscar Palomares, José L Subiza
BACKGROUND: Polymerized allergoids coupled to nonoxidized mannan (PM-allergoids) may represent novel vaccines targeting dendritic cells (DCs). PM-allergoids are better captured by DCs than native allergens and favor Th1/Treg cell responses upon subcutaneous injection. Herein we have studied in mice the in vivo immunogenicity of PM-allergoids administered sublingually in comparison to native allergens. METHODS: Three immunization protocols (4-8 weeks long) were used in Balb/c mice...
January 10, 2018: Allergy
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