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Pavel Kolkhir, Natalia Pereverzina, Olga Olisova, Marcus Maurer
Chronic viral infections including those by hepatitis B (CHB) virus and hepatitis C (CHC) virus have been reported to be comorbidities of chronic spontaneous urticaria (CSU). Here, we performed the first comprehensive review of the peer-reviewed literature (Pubmed, Web of Science and Google Scholar) on the prevalence of CHB and CHC in patients with CSU and vice versa. The prevalence of CHB and CHC in CSU does not appear to be increased. Less than 5% and less than 2% of CSU patients have markers of CHB and CHC, respectively, according to most of the 32 studies reviewed...
May 22, 2018: Allergy
Kotryna Simonyté Sjödin, Marie-Louise Hammarström, Patrik Rydén, Andreas Sjödin, Olle Hernell, Lars Engstrand, Christina E West
BACKGROUND: Compositional changes of the early life gut microbiota have been implicated in IgE-associated allergic disease but there is lack of longitudinal studies. We examined gut microbiota development from infancy to school age in relation to onset of IgE-associated allergic diseases. At 8 years of age, we also examined the relationship between gut microbiota and T-cell regulation, estimated as responses to polyclonal T-cell activation. METHODS: Stool samples were collected from 93 children at 4, 6 and 13 months, and 8 years of age...
May 22, 2018: Allergy
Dong Keon Yon, Seung Won Lee, Eun Kyo Ha, Kyung Suk Lee, Young-Ho Jung, Hye Mi Jee, Mi Ae Kim, Jae-Cheol Ahn, Youn Ho Sheen, Man Yong Han
Extensive studies support the presence of links between dyslipidemia and allergic diseases, and there has been with particular emphasis on allergen sensitization1-3 , asthma2,4 , and atopic dermatitis (AD). Although evidence supporting a link of allergic rhinitis (AR) with dyslipidemia is limited and controversial2,3 , many researchers have focused on the relationship of obesity and rhinitis, rather than blood lipids.5 This study determined the association of different blood lipids with current rhinitis and rhinitis-related parameters, including nasal symptoms, peripheral olfactory function, and nasal volume...
May 22, 2018: Allergy
Margitta Worm, Tim Higenbottam, Oliver Pfaar, Ralph Mösges, Werner Aberer, Kulasiri Gunawardena, Dorothea Wessiepe, Denise Lee, Matthias F Kramer, Murray Skinner, Bev Lees, Stefan Zielen
BACKGROUND: The Birch Allergoid, Tyrosine Adsorbate, Monophosphoryl Lipid A (POLLINEX® Quattro Plus 1.0 ml Birch 100%) is an effective, well-tolerated short course subcutaneous immunotherapy. We performed two phase II studies to determine its optimal cumulative dose. METHODS: The studies were conducted in Germany, Austria and Poland (EudraCT numbers: 2012-004336-28 PQBirch203 and 2015-000984-15 PQBirch204) using a wide range of cumulative doses. In both studies, subjects were administered 6 therapy injections weekly outside the pollen season...
May 19, 2018: Allergy
Lucie Mondoulet, Vincent Dioszeghy, Florence Busato, Camille Plaquet, Véronique Dhelft, Kevin Bethune, Laurence Leclere, Christian Daviaud, Mélanie Ligouis, Hugh Sampson, Christophe Dupont, Jörg Tost
BACKGROUND: Epicutaneous immunotherapy (EPIT) is a promising method for treating food allergies. In animal models, EPIT induces sustained unresponsiveness and prevents further sensitization mediated by Tregs. Here, we elucidate the mechanisms underlying the therapeutic effect of EPIT, by characterizing the kinetics of DNA methylation changes in sorted cells from spleen and blood and by evaluating its persistence and bystander effect compared to oral immunotherapy (OIT). METHODS: BALB/c mice orally sensitized to peanut proteins (PPE) were treated by EPIT using a PPE-patch or by PPE-OIT...
May 19, 2018: Allergy
Rachel Rignault-Bricard, François Machavoine, Salah Mecheri, Olivier Hermine, Elke Schneider, Michel Dy, Maria Leite-de-Moraes
BACKGROUND: Basophils are commonly associated with allergic responses because of their ability to produce large amounts of pro-Th2 cytokines and histamine. However, the mechanisms through which bone marrow-resident basophils (BMRB) become fully competent cytokine and histamine producers in response to IgE crosslinking are poorly understood. Here, we sought to determine the role of IL-3 in promoting pro-Th2 basophils. METHODS: BMRB and basophils exposed to IL-3 in vitro and in vivo were evaluated for their production of Th2 cytokines and histamine in response to FcεRI crosslinking on both protein and gene expression levels...
May 19, 2018: Allergy
Kozeta Miliku, Bianca Robertson, Atul K Sharma, Padmaja Subbarao, Allan B Becker, Piushkumar J Mandhane, Stuart E Turvey, Diana L Lefebvre, Malcolm R Sears, Lars Bode, Meghan Azad
Allergies originate early in life and food sensitization is often the first manifestation of allergic disease (1). Breastfeeding has been inconsistently associated with allergic conditions (2). These inconsistencies could reflect differences in human milk composition, which varies across different settings and populations. However, it remains poorly understood which of the bioactive components in human milk contribute to the developmental programming of allergic disease. This article is protected by copyright...
May 18, 2018: Allergy
C Palladino, M S Narzt, M Bublin, M Schreiner, P Humeniuk, M Gschwandtner, C Hafner, W Hemmer, K Hoffmann-Sommergruber, M Mildner, O Palomares, F Gruber, H Breiteneder
Currently, the earliest cellular and molecular signals driving allergic sensitization to peanuts are not fully understood, even though peanut allergens have been studied extensively. Meanwhile, lipids contained within allergen sources are emerging as players in the pathogenesis of allergies. Exposure of infants to peanut oil-containing lotions was described as a risk factor for the development of peanut allergy (1). This article is protected by copyright. All rights reserved.
May 10, 2018: Allergy
Vaibhav Jain, Shikha Raina, Atish Prabhakar Gheware, Rita Singh, Rakhshinda Rehman, Vinny Negi, Tracy Murray Stewart, Ulaganathan Mabalirajan, Adarsh Kumar Mishra, Robert A Casero, Anurag Agrawal, Balaram Ghosh
BACKGROUND: Airway epithelial injury is a crucial component of acute and severe asthma pathogenesis and a promising target for treatment of refractory asthma. However, the underlying mechanism of epithelial injury remains poorly explored. Though high levels of polyamines, mainly spermine, have been found in asthma and co-morbidity, their role in airway epithelial injury and the cause of their altered levels in asthma has not been explored. METHODS: We measured key polyamine metabolic enzymes in lung samples from normal and asthmatic subjects and in mice with OVA-induced allergic airway inflammation (AAI)...
May 5, 2018: Allergy
Riikka J Lund, Maria Osmala, Maia Malonzo, Minna Lukkarinen, Annamari Leino, Jussi Salmi, Sanna Vuorikoski, Riitta Turunen, Tytti Vuorinen, Cezmi Akdis, Harri Lähdesmäki, Riitta Lahesmaa, Tuomas Jartti
Children with rhinovirus-induced severe early wheezing have an increased risk of developing asthma later in life. The exact molecular mechanisms for this association are still mostly unknown. To identify potential changes in the transcriptional and epigenetic regulation in rhinovirus-associated atopic or non-atopic asthma we analyzed a cohort of 5-year-old children (n = 45) according to the virus etiology of the first severe wheezing episode at the mean age of 13 months and to five-year asthma outcome. The development of atopic asthma in children with early rhinovirus-induced wheezing was associated with DNA methylation changes at several genomic sites in chromosomal regions previously linked to asthma...
May 5, 2018: Allergy
Matthew Cole, Karen Bandeen-Roche, Annemarie G Hirsch, Jordan Kuiper, Agnes S Sundaresan, Bruce K Tan, Robert P Schleimer, Robert C Kern, Brian S Schwartz
BACKGROUND: Sinonasal symptoms are common and can have several underlying causes. When symptoms occur in specified patterns lasting three months or more they meet criteria for chronic rhinosinusitis (CRS). Approaches to CRS symptom measurement do not specify how to measure symptoms and treat specified sinonasal symptoms as generally interchangeable, suggesting that such symptoms should cluster on one or two latent factors. METHODS: We used questionnaire responses to 37 questions on presence, severity, bother, and frequency of cardinal sinonasal and related symptoms lasting three months, from 3535 subjects at three time points over 16 months...
May 5, 2018: Allergy
Alessandra Vultaggio, Francesca Nencini, Alessia Carraresi, Sara Pratesi, Robert Movérare, Camilla Eriksson, Lennart Venemalm, Enrico Maggi, Andrea Matucci
BACKGROUND: Infliximab (IFX) carries potential risk of immunogenicity with the production of anti-drug antibodies (ADA). ADA may belong to different isotypes and are usually measured by ELISA bridging assay. This test is not designed to detect IgG4 antibodies. The aim was to measure IgG4 anti-IFX antibodies in a cohort of IFX-treated patients and to evaluate their relationship with ADA and their clinical impact. METHODS: ADA were detected by using a bridging ELISA in the serum of 222 treated patients with different clinical outcomes to IFX...
May 2, 2018: Allergy
M Ödling, N Andersson, S Ekström, E Melén, A Bergström, I Kull
Asthma often debuts in early life (1). During childhood, the prevalence of asthma is higher in boys, but prevalence is higher in girls after puberty (2). The goal of asthma treatment is to achieve and maintain asthma control as well as reduce future risks of exacerbations (3). This article is protected by copyright. All rights reserved.
May 2, 2018: Allergy
Karin C Lødrup Carlsen, Eva Maria Rehbinder, Håvard O Skjerven, Monica Hauger Carlsen, Thea Aspelund Fatnes, Pål Fugelli, Berit Granum, Guttorm Haugen, Gunilla Hedlin, Christine Monceyron Jonassen, Linn Landrø, Jon Lunde, Benjamin J Marsland, Björn Nordlund, Knut Rudi, Katrine Sjøborg, Cilla Söderhäll, Anne Cathrine Staff, Riyas Vettukattil, Kai-Håkon Carlsen
Reversing or aborting the increase in allergic and other immune-related non-communicable diseases (NCDs) in the western world, first observed for allergic rhinitis from the 1890ies1 , requires primary prevention strategies, probably on a general population level. The diseases are likely to be related to changes in lifestyle, environment or both2 , including reduced microbial diversity, increased use of xenobiotics in industrial and consumer products, exposure to tobacco or nicotinic products and variations in diets and nutritional elements...
April 30, 2018: Allergy
Marc A Riedl, Emel Aygören-Pürsün, James Baker, Henriette Farkas, John Anderson, Jonathan A Bernstein, Laurence Bouillet, Paula Busse, Michael Manning, Markus Magerl, Mark Gompels, Aarnoud P Huissoon, Hillary Longhurst, William Lumry, Bruce Ritchie, Ralph Shapiro, Daniel Soteres, Aleena Banerji, Mauro Cancian, Douglas T Johnston, Timothy J Craig, David Launay, H Henry Li, Myron Liebhaber, Timothy Nickel, Jacob Offenberger, William Rae, Rik Schrijvers, Massimo Triggiani, H James Wedner, Sylvia Dobo, Melanie Cornpropst, Desiree Clemons, Lei Fang, Phil Collis, William P Sheridan, Marcus Maurer
BACKGROUND: Effective inhibition of plasma kallikrein may have significant benefits for patients with hereditary angioedema due to deficiency of C1 inhibitor (C1-INH-HAE) by reducing the frequency of angioedema attacks. Avoralstat is a small molecule inhibitor of plasma kallikrein. This study (OPuS-2) evaluated the efficacy and safety of prophylactic avoralstat 300 or 500 mg compared with placebo. METHODS: OPuS-2 was a Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study...
April 24, 2018: Allergy
Tal Erlich, Israa Sharkia, Nadine Landolina, Miri Assayag, Omer Goldberger, Neville Berkman, Francesca Levi-Schafer, Ehud Razin
Recently we have shown that mast cell mitochondrial STAT3 could serve as a new target for the regulation of the allergic response as it plays an essential role in immunologically-mediated degranulation of mast cells. In the present work, we explored how two recently developed mitochondrial STAT3 inhibitors (Mitocur-1 and Mitocur-3) modulate the allergic response. Here we show that treatment of rodent and human cultured mast cells with low concentrations of mitochondrial STAT3 inhibitors had no effect on STAT3 target gene expression...
April 23, 2018: Allergy
Jung U Shin, Seo Hyeong Kim, Ji Yeon Noh, Ji Hye Kim, Kim Hye Ran, Kyoung Yong Jeong, Kyung Hee Park, Jungsoo Lee, Howard Chu, Jae-Hyun Lee, Tai-Soon Yong, Jung-Won Park, Kwang Hoon Lee
BACKGROUND: Several studies have demonstrated that allergen-specific immunotherapy (SIT) can be an effective treatment for atopic dermatitis (AD). However, there is no relevant mouse model to investigate the mechanism and validate the novel modality of SIT in AD. METHODS: NC/Nga mice with induced AD-like skin lesions received a subcutaneous injection of SIT (an extract of the house dust mite Dermatophagoides farinae [DfE]) or placebo for 5 weeks). Clinical and histological improvements of AD-like skin lesions were examined...
April 21, 2018: Allergy
L Y Feldman, J D Thacher, M van Hage, I Kull, E Melén, G Pershagen, M Wickman, T To, J L Protudjer, A Bergström
No abstract text is available yet for this article.
April 19, 2018: Allergy
R S Mueller, E Jensen-Jarolim, F Roth-Walter, E Marti, J Janda, A A Seida, D DeBoer
In human patients with seasonal allergic rhinoconjunctivitis sensitized to grass pollen, the first successful allergen immunotherapy (AIT) was reported in 1911. Today, immunotherapy is an accepted treatment for allergic asthma, allergic rhinitis and hypersensitivities to insect venom. AIT is also used for atopic dermatitis and recently for food allergy. Subcutaneous, epicutaneous, intralymphatic, oral and sublingual protocols of AIT exist. In animals, most data are available in dogs where subcutaneous AIT is an accepted treatment for atopic dermatitis...
April 19, 2018: Allergy
Kazumasa Iwamoto, Tim J Stroisch, Susanne Koch, Nadine Herrmann, Nicole Leib, Thomas Bieber
BACKGROUND: The skin of atopic dermatitis (AD) patients presents a significant dysbalance of the microbiome with a high colonization by Staphylococcus aureus (S. aureus) which positively correlates with the severity of the disease. OBJECTIVE: Understanding the role of epidermal dendritic cells as link between the innate and the adaptive immune systems in AD. METHODS: Comparative phenotypic and functional analysis of TLR2 on Langerhans cells (LC) and inflammatory dendritic epidermal cells (IDEC) in organotypic models as well as freshly isolated cells from healthy and AD skin...
April 19, 2018: Allergy
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