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Q N Yu, Y B Guo, X Li, C L Li, W P Tan, X L Fan, Z L Qin, D Chen, W P Wen, S G Zheng, Q L Fu
BACKGROUND: Group 2 innate lymphoid cells (ILC2s) were closely associated with asthma. However, there were no perspective studies about the effects of glucocorticoid on ILC2s in asthma patients. Our objective was to perform a perspective study and evaluate the ILC2 activity after glucocorticoid therapy in asthma patients. METHODS: The asthma and asthma with allergic rhinitis patients were treated with glucocorticoid for 3 months. The circulating ILC2 levels were evaluated...
March 15, 2018: Allergy
Yasutaka Mitamura, Satoshi Nunomura, Yasuhiro Nanri, Masahiro Ogawa, Tomohito Yoshihara, Miho Masuoka, Gaku Tsuji, Takeshi Nakahara, Akiko Hashimoto-Hachiya, Simon J Conway, Masutaka Furue, Kenji Izuhara
BACKGROUND: Barrier dysfunction is an important feature of atopic dermatitis (AD) in which IL-4 and IL-13, signature type 2 cytokines, are involved. Periostin, a matricellular protein induced by IL-4 or IL-13, plays a crucial role in the onset of allergic skin inflammation, including barrier dysfunction. However, it remains elusive how periostin causes barrier dysfunction downstream of the IL-13 signal. METHODS: We systematically identified periostin-dependent expression profile using DNA microarrays...
March 12, 2018: Allergy
Min-Suk Yang, Dong-Yoon Kang, Bomi Seo, Hye Jung Park, So-Young Park, Mi-Yeong Kim, Kyung Hee Park, So-My Koo, Young-Hee Nam, Sujeong Kim, Jae-Woo Jung, Tae-Bum Kim, Gwang Cheon Jang, Hyeon-Jong Yang, Young-Min Ahn, Jung-Won Park, Hye-Ryun Kang
BACKGROUND: Few studies have investigated the incidence of anaphylaxis induced by individual or structurally similar cephalosporins. The aims of the study were to assess the incidence of cephalosporin-induced anaphylaxis and evaluate the clinical efficacy of screening skin tests. METHODS: In this retrospective cohort study, we obtained information on total cephalosporin use and cephalosporin-induced anaphylaxis in intravenous cephalosporin recipients in 12 general hospitals between 2013 and 2015...
March 8, 2018: Allergy
Fumie Ihara, Daiju Sakurai, Syuji Yonekura, Tomohisa Iinuma, Ryoji Yagi, Toshioki Sakurai, Toshihiro Ito, Asaka Matsuura, Yuki Morimoto, Tomoyuki Arai, Satoshi Suzuki, Kazufumi Katayama, Toshinori Nakayama, Yoshitaka Okamoto
BACKGROUND: Although Th2 cells are well known to play important roles in allergic diseases including allergic rhinitis (AR), the factors that induce and sustain the pathogenesis of AR remain unclear. The recent development of sublingual immunotherapy (SLIT) is expected to allow changes to the underlying pathogenesis of AR. However, which Th2 cell subsets are important in house dust mite-induced AR (HDM-AR), the influence of SLIT on the pathogenic Th2 cells, and the association of Th2 cell subsets with SLIT efficacy have not been clarified...
March 8, 2018: Allergy
Désirée Larenas-Linnemann, Sarbjit S Saini, Amyra Ali Azamar-Jácome, Marcus Maurer
We present 26 cases (ours and 25 from an extended literature review) in which chronic spontaneous urticaria (CSU) seems to be caused by a malignancy (mostly carcinoma or hematologic malignancy): the CSU precedes the neoplasia diagnosis by some months (2-8mo in 80%) and resolved days after chemotherapy/ surgical resection of the malignancy. In three patients, the urticaria flare-up alerted the treating physician of neoplasia recurrence. There could be publication bias, but the narrow time-span between cancer remission and urticaria resolution and especially the recurrence of urticaria that led to detection of cancer relapse in some of our cases are arguments in favor of a causal relationship...
March 8, 2018: Allergy
Ralph Mösges, Claus Bachert, Petr Panzner, Moises A Calderon, Ludo Haazen, Sabine Pirotton, Nathalie Wathelet, Stephen R Durham, Marie-Alix Bonny, Thierry Legon, Remy von Frenckell, Oliver Pfaar, Mohamed H Shamji
BACKGROUND: Immunotherapy with peptide hydrolysates from Lolium perenne (LPP) is an alternative treatment for seasonal allergic rhinitis with or without asthma. The aim of this study was to assess the clinical efficacy and safety of a cumulative dose of 170 μg LPP administered subcutaneously over 3 weeks. METHODS: In a randomized, double blind, placebo-controlled trial, 554 adults with grass pollen rhinoconjunctivitis were randomized (1:2 ratio) to receive 8 subcutaneous injections of placebo or 170 μg LPP administered in increasing doses in 4 visits over 3 weeks...
March 7, 2018: Allergy
Riikka E Lemmetyinen, Jussi V Karjalainen, Anna But, Risto L O Renkonen, Juha R Pekkanen, Sanna K Toppila-Salmi, Jari K Haukka
BACKGROUND: Higher all-cause mortality in asthmatics has been shown previously. Polysensitization is associated with higher morbidity among asthmatic children, and allergic rhinitis and/or allergic conjunctivitis (AR/AC) is associated with higher morbidity in adult asthmatics. Little is known about the effect of AR/AC and other factors on mortality among adult asthmatics. The aim was to study mortality and its risk factors in adults with and without asthma. METHODS: We randomly selected 1648 asthmatics with age over 30 years from national registers and matched the asthma sample with one or two controls...
February 20, 2018: Allergy
Gordon Sussman, Mohamed Abuzakouk, Frédéric Bérard, Walter Canonica, Hanneke Oude Elberink, Ana Giménez-Arnau, Clive Grattan, Kelly Hollis, Shannon Hunter, André Knulst, Jean-Philippe Lacour, Charles Lynde, Alexander Marsland, Doreen McBride, Marcus Maurer, Alla Nakonechna, Javier Ortiz de Frutos, Maria Reynolds, Carolyn Sweeney, Haijun Tian, Karsten Weller, Daniel Wolin, Maria-Magdalena Balp
BACKGROUND: ASSURE-CSU revealed differences in physician and patient reporting of angioedema. This post-hoc analysis was conducted to evaluate the actual rate of angioedema in the study population and explore differences between patients with and without angioedema. METHODS: This international observational study assessed 673 patients with inadequately controlled chronic spontaneous urticaria (CSU). Physicians abstracted angioedema data from medical records, which were compared with patient-reported data...
February 20, 2018: Allergy
C D van Ginkel, M E Pettersson, A E J Dubois, G H Koppelman
This study describes the role of two STAT6 gene variants in food allergy using data of patients and their parents who underwent double-blind placebo-controlled food challenges (DBPCFCs). After quality control, 369 trios were analyzed including 262 children (71.0%) with food allergy. Associations were tested by family based association testing (FBAT). The A alleles of both SNPs were associated with food allergy (p=0.036 and p=0.013 for rs324015 and rs1059513, respectively). Furthermore, these A alleles were associated with peanut allergy, higher sIgE levels to both peanut and cow's milk, more severe symptoms and higher eliciting doses during peanut and cow's milk DBPCFCs (all p<0...
February 19, 2018: Allergy
O Pfaar, M Alvaro, V Cardona, E Hamelmann, R Mösges, J Kleine-Tebbe
Allergen immunotherapy (AIT) is a safe, effective treatment for allergic rhinoconjunctivitis and allergic asthma. However, AIT's clinical effect is still contested - primarily due to heterogeneity in clinical trial designs, study populations, therapeutic formulations and efficacy criteria. After discussing current concepts and unmet needs, an international panel of experts made several recommendations: (i) explore and validate definitions for [clinical] responders in AIT-trials; (ii) use of well-documented, standardized provocation tests prior to inclusion of subjects with relevant diseases in AIT trials; (iii) monitoring neo-sensitizations and occurrence of new allergy in extended AIT trials, and exclusion of polyallergic participants; (iv) validation of allergen exposure chambers with regard to natural exposure; (v) in studies of seasonal allergies, focus on peak exposure but also consider organising two parallel, geographically distinct but otherwise identical trials; (vi) discuss adaptive trial designs with the regulatory authorities; (vii) use e-health and m-health technologies to capture more information on individual exposure to allergens; (viii) initiate research on potential psychological, biochemical, immune, neural and even genomic markers of the placebo response; (ix) identify trial designs and primary endpoints that will give children with allergies easier, faster access to AIT formulations; and (x) promote and apply standardized methods for reporting systemic and local adverse events...
February 15, 2018: Allergy
Jung Yeon Hong, Mina Kim, In Suk Sol, Kyung Won Kim, Chang-Min Lee, Jack A Elias, Myung Hyun Sohn, Chun Geun Lee
BACKGROUND: Chitotriosidase (Chitnase 1, Chit1), a major true chitinase in humans, is induced in childhood asthma and has been implicated in the pathogenesis of a variety of inflammatory and tissue remodeling responses. We hypothesized that Chit1 plays a significant role in the pathogenesis of allergic asthma. To identify the role of Chit1, the mechanisms that underlie these contributions and the relevance of these murine findings to childhood asthma. METHODS: Wild type and Chit1-deficient mice and cells in culture were used to define the roles of Chit1 in models of allergic adaptive Th2 inflammation...
February 8, 2018: Allergy
Jing Liu, YingYing Li, Anand Kumar Andiappan, Yan Yan, Tan Kai Sen, Hsiao Hui Ong, Kim Thye Thong, Yew Kwang Ong, Feng Gang Yu, Heng Boon Low, Yong Liang Zhang, Li Shi, De Yun Wang
BACKGROUND: The IL-13 receptor α2 (IL-13Rα2) is a receptor for IL-13 which has conflicting roles in mediating IL-13 responses in the lower airway; with little known about its impact on upper airway diseases. We sought to investigate the expression of IL-13 receptors, IL-13Rα1 and IL-13Rα2, in chronically inflamed nasal epithelium, and explore IL-13 induced signaling pathways in an in vitro model of human nasal epithelial cells (hNECs). METHODS: The protein and mRNA expression levels of IL-13 and its receptors in nasal biopsies of patients with nasal polyps (NP) and healthy controls were evaluated...
February 6, 2018: Allergy
Frank Siebenhaar, Benno Sander, Huyen Tram, André Ellrich, Marcus Maurer, Karsten Weller
BACKGROUND: Mastocytosis is a heterogeneous disease characterized by a clonal expansion of mast cells in various organs. The vast majority of patients suffer from signs and symptoms caused by mediator release from mast cells. Although the disease burden is high, there is currently no specific and validated instrument to measure and monitor signs and symptoms in patients with mastocytosis. OBJECTIVE: To develop and validate a disease-specific tool to measure and monitor the activity of signs and symptoms in patients with mastocytosis, the Mastocytosis Activity Score (MAS)...
February 6, 2018: Allergy
J J Heeringa, L Rijvers, N J Arends, G J Driessen, S G Pasmans, J J M van Dongen, J C de Jongste, M C van Zelm
Despite the critical role of soluble IgE in the pathology of IgE-mediated allergic disease, little is known about abnormalities in the memory B-cells and plasma cells that produce IgE in allergic patients. We here applied a flowcytometric approach to cross-sectionally study blood IgE+ memory B-cells and plasmablasts in 149 children with atopic dermatitis, food allergy and/or asthma, and correlated these to helper-T(h)2 cells and eosinophils. Children with allergic disease had increased numbers of IgE+CD27- and IgE+CD27+ memory B-cells and IgE+ plasmablasts, as well as increased numbers of eosinophils and Th2 cells...
January 30, 2018: Allergy
Luise Worth, Sven Michel, Vincent D Gaertner, Michael Kabesch, Maximilian Schieck
TH 17 cells contribute to the pathogenesis of chronic inflammatory diseases such as asthma and TH 17 pathway tagging SNPs were associated with asthma and total serum IgE levels in childhood. In this study genotype-specific effects of these SNPs on the expression of TH 17 related molecules were analyzed in peripheral blood mononuclear cells (PBMCs) before and after allergen stimulation in 61 individuals. After correction for multiple testing, protein or mRNA expression levels of several molecules, including IL-17A, IL17-F, IL-23 and IL-23 receptor, were significantly correlated with asthma-associated SNPs (located in IL17F, IL22, IL23R and IL23A) and IgE-associated polymorphisms (located in IL17A and three SNPs in IL12B)...
January 30, 2018: Allergy
M Eleonore Pettersson, Gerard H Koppelman, Bertine Mj Flokstra-de Blok, Boudewijn J Kollen, Anthony Ej Dubois
BACKGROUND: There is currently considerable uncertainty regarding what the predictors of the severity of diagnostic or accidental food allergic reactions are, and to what extent the severity of such reactions can be predicted. OBJECTIVE: To identify predictors for the severity of diagnostic and accidental food allergic reactions and to quantify their impact. METHODS: The study population consisted of children with a double-blind, placebo-controlled food challenge (DBPCFC) confirmed food allergy to milk, egg, peanut, cashew nut and/or hazelnut...
January 30, 2018: Allergy
A Muraro, G Roberts, S Halken, A Agache, L Angier, M Fernandez-Rivas, R Gerth van Wijk, M Jutel, S Lau, G Pajno, O Pfaar, D Ryan, G J Sturm, R van Ree, E-M Varga, C Bachert, M Calderon, G W Canonica, S R Durham, H J Malling, U Wahn, A Sheikh
The allergist's community has recently celebrated 100 year of Allergen Immunotherapy (AIT). Unfortunately the implemention of this treatment is still impaired by some challenges. With the diversity of definitions, methodology and different allergen products used, research studies have produced conflicting outcomes. This has resulted in confusion about the benefits and risks of AIT amongst policymakers and professionals, as well as in the variable availability of AIT products, regulation and reimbursement policies globally...
January 30, 2018: Allergy
J Augé, J Vent, I Agache, L Airaksinen, P Campo Mozo, A Chaker, C Cingi, S R Durham, W J Fokkens, P Gevaert, A I Giotakis, P Hellings, M Herknerova, V Hox, L Klimek, C La Melia, J Mullol, N B Muluk, A Muraro, K Naito, O Pfaar, H Riechelmann, C Rondon, M Rudenko, B Samolinski, I Tasca, P V Tomazic, K Vogt, M Wagenmann, G Yeryomenko, L Zhang, R Mösges
Nasal allergen challenge (NAC) is an important tool to diagnose allergic rhinitis. In daily clinical routine, experimentally, or when measuring therapeutic success clinically, nasal allergen challenge is fundamental. It is further one of the key diagnostic tools when initiating specific allergen immunotherapy. So far, national recommendations offered guidance on its execution, however, international divergence left many questions unanswered. These differences in the literature caused EAACI to initiate a task force to answer unmet needs and find a consensus in executing nasal allergen challenge...
January 27, 2018: Allergy
Maili Lehto, Henrik Wolff, Reko Leino, Harri Alenius, Johannes Savolainen
BACKGROUND: Allergen specific immunotherapy (SIT) effectively alleviates type I allergic diseases characterized by T helper (Th) 2-type immunity. Our recent studies have shown that a synthetic trivalent glycocluster, triacedimannose (TADM), suppresses the Th2-type allergic inflammation. The aim of this study was to compare TADM with two well-known adjuvants, unmethylated cytocine-phosphate-guanine oligodeoxynucleotide (CpG) and monophosphoryl lipid A (MPLA) in a grass allergen induced chronic allergic inflammation model in mice...
January 26, 2018: Allergy
Marie Eliane Azoury, Lucia Filì, Rami Bechara, Noémie Scornet, Luc de Chaisemartin, Richard J Weaver, Nancy Claude, Bernard Maillere, Paola Parronchi, Delphine Joseph, Marc Pallardy
BACKGROUND: There is in vitro evidence that T-cells from allergic patients react to benzylpenicillin-human serum albumin (BP-HSA) bioconjugates. Our group has recently shown the existence of naïve CD4+ T lymphocytes recognizing BP-HSA in healthy donors. However, BP-haptenated peptides from HSA participating in the immunization of allergic patients have never been identified. The purpose of the present study is to identify immunodominant BP-haptenated peptides from HSA involved in immunization of patients to BP and to refine the frequency calculation of naïve CD4+ T-cells recognizing BP...
January 22, 2018: Allergy
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