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https://www.readbyqxmd.com/read/27906453/syk-inhibition-blocks-airway-constriction-and-protects-from-th2-induced-airway-inflammation-and-remodeling-in-mice
#1
Christoph Tabeling, Julia Herbert, Andreas C Hocke, David Lamb, Lutz Wollin, Klaus Erb, Ekaterina Boiarina, Hesam Movassagh, Jörg Scheffel, Jan M Doehn, Stefan Hippenstiel, Marcus Maurer, Abdelilah S Gounni, Wolfgang M Kuebler, Norbert Suttorp, Martin Witzenrath
BACKGROUND: Spleen tyrosine kinase (Syk) is an intracellular non-receptor tyrosine kinase, which has been implicated as central immune modulator promoting allergic airway inflammation. Syk inhibition has been proposed as a new therapeutic approach in asthma. However, the direct effects of Syk inhibition on airway constriction independent of allergen sensitization remain elusive. METHODS: Spectral confocal microscopy of human and murine lung tissue was performed to localize Syk expression...
December 1, 2016: Allergy
https://www.readbyqxmd.com/read/27896827/leaping-through-the-looking-glass-secondary-analysis-of-the-effect-of-skin-test-size-and-age-of-introduction-on-peanut-tolerance-after-early-peanut-introduction
#2
Matthew Greenhawt, David Fleischer, Edmond S Chan, Carina Venter, David Stukus, Ruchi Gupta, Jonathan Spergel
BACKGROUND: In the Learning Early About Peanut Allergy (LEAP) study, early peanut introduction in high-risk 4-11 month olds was associated with a significantly decreased risk of developing peanut allergy. However, the influences of key baseline high-risk factors on peanut tolerance are poorly understood. METHODS: Secondary analysis was conducted on the publically available LEAP dataset, exploring relationships between peanut tolerance, baseline peanut/egg sensitization, eczema severity/duration, age of introduction, gender, and race...
November 29, 2016: Allergy
https://www.readbyqxmd.com/read/27892597/a-multi-center-study-on-anaphylaxis-caused-by-peanut-tree-nuts-and-seeds-in-children-and-adolescents
#3
Kyunguk Jeong, So-Yeon Lee, Kangmo Ahn, Jihyun Kim, Hae-Ran Lee, Dong In Suh, Bok-Yang Pyun, Taek Ki Min, Ji-Won Kwon, Kyu-Earn Kim, Kyung Won Kim, Myung Hyun Sohn, Yoon Hee Kim, Tae Won Song, Jung Hyun Kwon, You Hoon Jeon, Hyung Young Kim, Jeong Hee Kim, Young Min Ahn, Sooyoung Lee
Peanut (PN) and tree nuts (TNs) are common causes of anaphylaxis in Western countries but no information is available in Korea. To feature clinical characteristics of anaphylaxis caused by PN, TNs, and seeds, a retrospective medical record review was performed in 14 university hospitals in Korea (2009-2013).One hundred and twenty-six cases were identified, with the mean age of 4.9 years. PN, walnut (WN), and pine nut accounted for 32.5%, 41.3%, and 7.1%, respectively. The median values of specific IgE (sIgE) to PN, WN and pine nut were 10...
November 28, 2016: Allergy
https://www.readbyqxmd.com/read/27886391/estimate-of-the-total-costs-of-allergic-rhinitis-in-specialized-care-based-on-real-world-data-the-ferin-study
#4
C Colás, M Brosa, E Antón, J Montoro, A Navarro, M T Dordal, I Dávila, B Fernández-Parra, M D P Ibáñez, M Lluch-Bernal, V Matheu, C Rondón, M C Sánchez, A Valero
BACKGROUND: Despite the socioeconomic importance of allergic rhinitis (AR), very few prospective studies have been performed under conditions of routine clinical practice and with a sufficiently long observation period outside the clinical trial scenario. We prospectively estimated the direct and indirect costs of AR in patients attending specialized clinics in Spain. METHODS: Patients were recruited at random from allergy outpatient clinics in 101 health centers throughout Spain over 12 months...
November 25, 2016: Allergy
https://www.readbyqxmd.com/read/27886390/green-yellow-and-red-risk-perception-in-everyday-life-a-communication-tool
#5
A Stensgaard, A DunnGalvin, D Nielsen, M Munch, C Bindslev-Jensen
BACKGROUND: Adolescents have the highest risk for food allergy-related fatalities. Our main aim was to investigate the level of risk in everyday social situations as perceived by adolescents/young adults with peanut allergy, their families and their friends. METHODS: The web-based 'Colours Of Risks' (COR) questionnaire was completed by 70 patients (aged 12-23 years), 103 mothers and fathers, 31 siblings (aged 12-26 years), and 42 friends (aged 12-24 years). COR deals with six main contexts (home, school/university, work, visiting/social activities, special occasions/parties, and vacations), each with 1-12 items...
November 25, 2016: Allergy
https://www.readbyqxmd.com/read/27886387/coping-strategies-alexithymia-and-anxiety-in-young-patients-with-food-allergy
#6
Laura Polloni, Audrey DunnGalvin, Emilia Ferruzza, Roberta Bonaguro, Francesca Lazzarotto, Alice Toniolo, Nicolò Celegato, Antonella Muraro
BACKGROUND: Food allergy is major public health concern affecting nearly 15 million Americans and 80 million Europeans. Risk of anaphylaxis and implications for social activities affect patients' quality of life and psychological wellbeing. We previously found that young patients reported higher levels of alexithymia (difficulty in recognizing and expressing emotions) compared to healthy peers, and may influence affect, management style and clinical outcomes. This study aimed to explore links between coping strategies, alexithymia and anxiety among food-allergic adolescents and young adults...
November 25, 2016: Allergy
https://www.readbyqxmd.com/read/27886386/costs-of-perennial-allergic-rhinitis-and-allergic-asthma-increase-with-severity-and-poor-disease-control
#7
Manon Belhassen, Pascal Demoly, Evelyne Bloch-Morot, Gérard de Pouvourville, Marine Ginoux, Antoine Chartier, Laurent Laforest, Niels Serup-Hansen, Massoud Toussi, Eric Van Ganse
BACKGROUND: Perennial allergic rhinitis (PAR) represents a global and public health problem, due to its prevalence, morbidity, and impact on the quality of life. PAR is frequently associated to allergic asthma (AA). Costs of PAR with or without AA are poorly documented. OBJECTIVE: Our study aimed to detail medical resource utilization (MRU) and related direct cost for PAR, with or without concomitant AA, in France. METHODS: Using Electronic Health Records (EHRs), we identified in 2010 two cohorts of PAR patients, based on General Practitioners' diagnoses and prescribing data, with and without concomitant AA...
November 25, 2016: Allergy
https://www.readbyqxmd.com/read/27874209/airway-eosinophil-migration-into-lymph-nodes-in-mice-depends-on-leukotriene-c4
#8
Hai-Bin Wang, Praveen Akuthota, Yoshihide Kanaoka, Peter F Weller
BACKGROUND: We previously demonstrated in mice that airway eosinophils traffic from the airway lumen into lung-draining paratracheal lymph nodes. However, mechanisms whereby eosinophils traverse from the lungs and home to paratracheal lymph nodes remain unclear. We investigated roles of cysteinyl leukotrienes in mediating eosinophil trafficking from lungs to paratracheal lymph nodes. METHODS: The expression of CCR7 was determined by flow cytometry. Transwell assays were used to test chemotactic responses of leukotriene C4 synthase-deficient and control airway eosinophils to the chemokine CCL19 ex vivo...
November 22, 2016: Allergy
https://www.readbyqxmd.com/read/27874204/field-testing-the-new-anaphylaxis-classification-for-the-who-international-classification-of-diseases-icd-11-revision
#9
Luciana Kase Tanno, Nicolas Molinari, Sophie Bruel, Jean-Luc Bourrain, Moises A Calderon, Pierre Aubas, Pascal Demoly
BACKGROUND: In order to consolidate the new classification model addressed to the allergic and hypersensitivity conditions according to the International Classification of Diseases (ICD)-11 revision timeline, we here propose real-life application of quality assurance methodology to evaluate sensitivity and accuracy of the "Anaphylaxis" subsection. METHODS: We applied field-testing methodology by analyzing all the consecutive inpatients' files documented as allergies from the University Hospital of Montpellier electronic database for the period of one year...
November 22, 2016: Allergy
https://www.readbyqxmd.com/read/27874202/defining-pollen-exposure-times-for-clinical-trials-of-allergen-immunotherapy-for-pollen-induced-rhinoconjunctivitis-an-eaaci-position-paper
#10
O Pfaar, K Bastl, U Berger, J Buters, M A Calderon, B Clot, U Darsow, P Demoly, S R Durham, C Galán, R Gehrig, R Gerth van Wijk, L Jacobsen, L Klimek, M Sofiev, M Thibaudon, K C Bergmann
BACKGROUND: Clinical efficacy of pollen allergen immunotherapy has been broadly documented in randomized controlled trials. The underlying clinical endpoints are analysed in seasonal time periods pre-defined on the basis of the background pollen concentration. However, any validated or generally accepted definition from academia or regulatory authorities for this relevant pollen-exposure intensity or period of time (season) is currently not available. Therefore, this Task Force initiative of the European Academy of Allergy and Clinical Immunology (EAACI) aimed to propose definitions based on expert-consensus...
November 22, 2016: Allergy
https://www.readbyqxmd.com/read/27873335/lip-b-1-is-a-novel-allergenic-protein-isolated-from-the-booklouse-liposcelis-bostrychophila
#11
O Ishibashi, K Sakuragi, Y Fukutomi, Y Kawakami, Y Kamata, M Sakurai, S Nakayama, H Uchiyama, H Kobayashi, H Kojima, T Inui
BACKGROUND: Booklice, belonging to the order Psocoptera, are small household insect pests that are distributed worldwide. Liposcelis bostrychophila (L. bostrychophila), a common home-inhabiting species of booklouse, infests old books, sheets of paper and stored food. Recent entomological and serological studies demonstrated that L. bostrychophila accounted for the majority of detectable insects in house dust and could be a potent inducer of respiratory allergy. Our recent proteomic analysis identified a potent allergenic protein from L...
November 22, 2016: Allergy
https://www.readbyqxmd.com/read/27873330/the-burden-of-non-adherence-among-adults-with-asthma-a-role-for-shared-decision-making
#12
Samantha Pollard, Nick Bansback, J Mark FitzGerld, Stirling Bryan
A shared approach to decision making framework has been suggested for chronic disease management especially where multiple treatment options exist. Shared decision making (SDM) requires that both physicians and patients are actively engaged in the decision-making process, including information exchange; expressing treatment preferences; as well as agreement over the final treatment decision. Although SDM appears well supported by patients, practitioners and policy makers alike, the current challenge is to determine how best to make SDM a reality in everyday clinical practice...
November 22, 2016: Allergy
https://www.readbyqxmd.com/read/27864967/chemokine-receptors-in-allergic-diseases
#13
REVIEW
Laure Castan, Antoine Magnan, Grégory Bouchaud
Under homeostatic conditions, as well as in various diseases, leucocyte migration is a crucial issue for the immune system that is mainly organized through the activation of bone marrow-derived cells in various tissues. Immune cell trafficking is orchestrated by a family of small proteins called chemokines. Leucocytes express cell-surface receptors that bind to chemokines and trigger transendothelial migration. Most allergic diseases, such as asthma, rhinitis, food allergies and atopic dermatitis, are generally classified by the tissue rather than the type of inflammation; making the chemokine/chemokine receptor system a key point of the immune response...
November 16, 2016: Allergy
https://www.readbyqxmd.com/read/27864954/prevalence-of-comorbidity-and-associated-risk-factors-in-adults-with-atopic-dermatitis
#14
Alexander Egeberg, Yuki M F Andersen, Gunnar H Gislason, Lone Skov, Jacob P Thyssen
BACKGROUND: Atopic dermatitis (AD) is a common chronic skin disorder, which may persist into adulthood, however the prevalence of comorbidities in patients with AD is not well characterized. AD is considered a systemic disorder like psoriasis, which has raised a need for data on the comorbidity profile of patients with AD, to assess the potential risks, benefits, and complications in management of patients with AD. We described the occurrence of medical and psychiatric comorbidities and associated risk factors in adults with AD compared with psoriasis and the general population...
November 16, 2016: Allergy
https://www.readbyqxmd.com/read/27861999/forkhead-box-protein-3-foxp3-producing-dendritic-cells-suppress-allergic-response
#15
Xiao-Yu Liu, Ling-Zhi Xu, Xiang-Qian Luo, Xiao-Rui Geng, Zhi-Qiang Liu, Li-Teng Yang, Gui Yang, Si Chen, Zhi-Gang Liu, Hua-Bin Li, Li-Tao Yang, Tian-Gang Luan, Ping-Chang Yang
BACKGROUND: The generation of the tolerogenic dendritic cells (DC) is not fully understood yet. Forkhead box protein-3 (Foxp3) is an important molecule in the immune tolerance. This study tests a hypothesis that DCs express Foxp3, which can be up regulated by Staphylococcal enterotoxin B (SEB). METHODS: The expression of Foxp3 by DCs was evaluated by real time RT-PCR, Western blotting, flow cytometry and chromatin immunoprecipitation assay. RESULTS: We observed that mice treated with SEB at 0...
November 15, 2016: Allergy
https://www.readbyqxmd.com/read/27861994/detection-of-drug-responsive-b-lymphocytes-and-anti-drug-igg-in-patients-with-%C3%AE-lactam-hypersensitivity
#16
Mohammed O Amali, Andrew Sullivan, Rosalind E Jenkins, John Farrell, Xiaoli Meng, Lee Faulkner, Paul Whitaker, Daniel Peckham, B Kevin Park, Dean J Naisbitt
BACKGROUND: Delayed-type β-lactam hypersensitivity develops in subset of patients. The cellular immunological processes that underlie the drug-specific response have been described; however, little is known about involvement of the humoral immune system. Thus, the aim of this study was to utilize piperacillin hypersensitivity as an exemplar to (1) develop cell culture methods for the detection of drug-specific B cell responses, (2) characterize drug-specific IgG subtypes and (3) assess reactivity of IgG antibodies against proteins modified to different levels with piperacillin haptens...
November 15, 2016: Allergy
https://www.readbyqxmd.com/read/27861988/mechanisms-of-action-that-contribute-to-efficacy-of-omalizumab-in-chronic-spontaneous-urticaria
#17
REVIEW
Allen P Kaplan, Ana M Giménez-Arnau, Sarbjit Singh Saini
The monoclonal anti-immunoglobulin E (IgE) antibody, omalizumab, was the first drug approved for use in patients with chronic idiopathic/spontaneous urticaria (CIU/CSU) who remain symptomatic despite H1 -antihistamine treatment. Omalizumab binds to free IgE, which lowers free IgE levels and causes FcεRI receptors on basophils and mast cells to be downregulated. It has been shown to improve symptoms of CIU/CSU, but its mechanism of action is not currently understood. Potential mechanisms in CIU/CSU include reducing mast cell releasability, reversing basopenia and improving basophil IgE receptor function, reducing activity of IgG autoantibodies against FcεRI and IgE, reducing activity of IgE autoantibodies against an antigen or autoantigen that has yet to be definitively identified, reducing the activity of intrinsically "abnormal" IgE, and decreasing in vitro coagulation abnormalities associated with disease activity...
November 15, 2016: Allergy
https://www.readbyqxmd.com/read/27859359/cashew-allergy-risks-2s-albumins-and-predictions-based-on-ige-antibody-levels
#18
EDITORIAL
Jörg Kleine-Tebbe, Robert G Hamilton
We read with great interest the report of Lange et al (1) that studied cashew allergic children and the potential predictive value of cashew 2S albumin storage protein (Ana o 3)-specific IgE measurements in determining the need for an oral cashew challenge to prove disease. They report that IgE antibody levels >2 kUA /l to Ana o 3 improved their prediction (95% probability) of a positive oral food challenge after cashew consumption in comparison to IgE against the whole cashew extract. In other words, increased analytical specificity of molecular Ana o 3-specific IgE testing (2) reportedly translates into an improved diagnostic efficacy and a superior prediction for a positive oral cashew challenge...
November 15, 2016: Allergy
https://www.readbyqxmd.com/read/27859351/exosomes-in-immunoregulation-of-chronic-lung-diseases
#19
REVIEW
K P Hough, D Chanda, S R Duncan, V J Thannickal, J S Deshane
Exosomes are nano-sized, membrane-bound vesicles released from cells that transport cargo including DNA, RNA, and proteins, between cells as a form of intercellular communication. In addition to their role in intercellular communication, exosomes are beginning to be appreciated as agents of immunoregulation that can modulate antigen presentation, immune activation, suppression and surveillance. This article summarizes how these multifaceted functions of exosomes may promote development and/or progression of chronic inflammatory lung diseases including asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis...
November 15, 2016: Allergy
https://www.readbyqxmd.com/read/27859399/cd48-on-blood-leukocytes-and-in-serum-of-asthma-patients-varies-with-severity
#20
R S Gangwar, Y Minai-Fleminger, M Seaf, A Gutgold, A Shikotra, C Barber, A Chauhan, S Holgate, P Bradding, P Howarth, R Eliashar, N Berkman, F Levi-Schaffer
BACKGROUND: CD48 is a membrane receptor (mCD48) on eosinophils and mast cells and exists in a soluble form (sCD48). CD48 has a pivotal role in murine asthma and in the proinflammatory interactions of mast cells with eosinophils via its ligand CD244. Thus, CD48 might be important in human asthma. METHODS: Therefore, two separate cohorts (IL and UK) comprising mild, moderate, and severe asthma and healthy volunteers were evaluated for blood leukocyte mCD48 expression and sCD48 in serum...
November 10, 2016: Allergy
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