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Thomas Boehm, Birgit Reiter, Robin Ristl, Karin Petrosczi, Wolfgang Sperr, Thomas Stimpfl, Peter Valent, Bernd Jilma
BACKGROUND: Histaminolytic activity mediated by diamine oxidase (DAO) is present in plasma after induction of severe anaphylaxis in rats, guinea pigs and rabbits. Heparin released during mast cell degranulation in the gastrointestinal tract might liberate DAO from heparin-sensitive storage sites. DAO release during anaphylaxis has not been demonstrated in humans. METHODS: Plasma DAO, tryptase and histamine concentrations of four severe anaphylaxis events were determined at multiple serial time points in two patients with systemic mastocytosis...
November 12, 2018: Allergy
Anna M Hedman, Cecilia Lundholm, Annika Scheynius, Johan Alm, Ellika Andolf, Göran Pershagen, Catarina Almqvist
No abstract text is available yet for this article.
November 8, 2018: Allergy
Min Jung Kim, Doo Hee Shim, Hye-Ran Cha, Kuk-Young Moon, Chang Mo Yang, Su Jin Hwang, Kyung Won Kim, Jeon Han Park, Chun Geun Lee, Jack A Elias, Myung Hyun Sohn, Jae Myun Lee
BACKGROUND: Chitinase 3-like 1 protein (CHI3L1) (YKL-40 in humans and breast regression protein [BRP]-39 in mice) is required for optimal allergen sensitization and Th2 inflammation in various chronic inflammatory diseases including asthma. However, the role of CHI3L1 in airway inflammation induced by respiratory viruses has not been investigated. The aim of this study is to investigate the relationship between CHI3L1 and airway inflammation caused by respiratory syncytial virus (RSV) infection...
November 7, 2018: Allergy
Antonia Fettelschoss-Gabriel, Victoria Fettelschoss, Florian Olomski, Katharina Birkmann, Franziska Thoms, Maya Bühler, Martin Kummer, Andris Zeltins, Thomas M Kündig, Martin F Bachmann
BACKGROUND: Insect-bite hypersensitivity (IBH) in horses is a chronic allergic dermatitis caused by insect bites. Horses suffer from pruritic skin lesions, caused by type-I/type-IV allergic reactions accompanied by prominent eosinophil infiltration into the skin. Interleukin-5 (IL-5) is the key cytokine for eosinophils and we have previously shown that targeting IL-5 by vaccination reduces disease symptoms in horses. OBJECTIVE: Here we analyzed the potential for long-term therapy by assessing a second follow-up year of the previously published study...
November 7, 2018: Allergy
Mario C Manresa, Leila Smith, Laura Casals-Diaz, Raphael R Fagundes, Eric Brown, Praveen Radhakrishnan, Stephen J Murphy, Bianca Crifo, Moritz J Strowitzki, Doug N Halligan, Ellen H van den Bogaard, Hanna Niehues, Martin Schneider, Cormac T Taylor, Martin Steinhoff
BACKGROUND: When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of cellular hypoxia. The hypoxia-inducible factor-1α (HIF-1α) promotes an adaptive transcriptional response to hypoxia and as such is a major regulator of immune cell survival and function. HIF hydroxylases are the family of oxygen-sensing enzymes primarily responsible for conferring oxygen-dependence upon the HIF pathway...
November 5, 2018: Allergy
Marta Ponce, Fabian Schroeder, Christina Bannert, Klara Schmidthaler, Christian Skjødt Hansen, Katrine Lindholm Bøgh, Regina Soldo, Stephen Kwok-Wing Tsui, Andreas Weinhäusel, Zsolt Szépfalusi, Thomas Eiwegger
BACKGROUND: The preventive effect of allergen immunotherapy (AIT) on allergy and asthma development is currently assessed using primary and secondary AIT approaches. Knowledge of the immunological effects of these interventions is limited and the impact on epitope diversity remains to be defined. METHODS: We used high-density peptide arrays that included all known Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f) allergens and the whole proteome of Der f to study changes in House Dust Mite (HDM) linear peptide recognition during a 2-year preventive double-blind placebo-controlled sublingual HDM AIT pilot study in 2-5-year-old children with sensitization to HDM but without symptoms...
November 5, 2018: Allergy
A Wilcock, R Bahri, S Bulfone-Paus, P D Arkwright
Mast cells are typically linked to immediate hypersensitivity and anaphylaxis. This review looks beyond this narrow role, focusing on how these cells have evolved and diversified via natural selection promoting serine protease gene duplication, augmenting their innate host defence function against helminths and snake envenomation. Plasticity of mast cell genes has come at a price. Somatic activating mutations in the mast cell growth factor KIT gene causes cutaneous mastocytosis in young children, and systemic mastocytosis with a more guarded prognosis in adults who may also harbor other gene mutations with oncogenic potential as they age...
November 3, 2018: Allergy
Caroline Roduit, Remo Frei, Ruth Ferstl, Susanne Loeliger, Patrick Westermann, Claudio Rhyner, Elisa Schiavi, Weronika Barcik, Noelia Rodriguez-Perez, Marcin Wawrzyniak, Christophe Chassard, Christophe Lacroix, Elisabeth Schmausser-Hechfellner, Martin Depner, Erika von Mutius, Charlotte Braun-Fahrländer, Anne Karvonen, Pirkka Kirjavainen, Juha Pekkanen, Jean-Charles Dalphin, Josef Riedler, Cezmi Akdis, Roger Lauener, Liam O'Mahony
BACKGROUND: Dietary changes are suggested to play a role in the increasing prevalence of allergic diseases and asthma. Short-chain fatty acids (SCFAs) are metabolites present in certain foods and are produced by microbes in the gut following fermentation of fibers. SCFAs have been shown to have anti-inflammatory properties in animal models. Our objective was to investigate the potential role of SCFAs in the prevention of allergy and asthma. METHODS: We analysed SCFAs levels by HPLC (High Performance Liquid Chromatography) in fecal samples from 301 one-year old children from a birth cohort and examined their association with early life exposures, especially diet, and allergy and asthma later in life...
November 3, 2018: Allergy
Yingluo Xiong, Xinyi Cui, Wenjing Li, Jiaoyan Lv, Lixia Du, Wenli Mi, Huabin Li, Zhengrong Chen, Qibin Leng, Hong Zhou, Rui He
BACKGROUND: Epithelial cells (ECs) play a crucial role in allergic sensitization to inhaled protease allergens by instructing type 2 innate lymphoid cells (ILC2) and dendritic cells (DCs) via release of pro-type 2 cytokines, particularly interleukin-33 (IL-33). Leukotriene B4 (LTB4) is a well-known leukocyte chemoattractant via engagement of its receptor 1 (BLT1). However, the role of LTB4-BLT1 axis in allergic sensitization via activation of ECs is still unknown. METHODS: We evaluated the effect of LTB4-BLT1 axis on IL-33 expression and ILC2 activation in vivo and in vitro...
November 3, 2018: Allergy
Tsung-Chieh Yao, Ren-Hua Chung, Chung-Yen Lin, Pei-Chien Tsai, Wei-Chiao Chang, Kuo-Wei Yeh, Ming-Han Tsai, Sui-Ling Liao, Man-Chin Hua, Shen-Hao Lai, Li-Chen Chen, Su-Wei Chang, Ya-Wen Yu, Jing-Ya Hsu, Su-Ching Chang, Wen-Chih Cheng, Donglei Hu, Xiumei Hong, Esteban G Burchard, Xiaobin Wang, Jung-Ying Tzeng, Hui-Ju Tsai, Jing-Long Huang
No abstract text is available yet for this article.
October 31, 2018: Allergy
O Pfaar, H Lou, Y Zhang, L Klimek, L Zhang
Allergen immunotherapy (AIT) is the only disease-modifying treatment option for patients with IgE-mediated inhalant allergies. Though used in clinical practice for more than 100 years, most innovations in AIT efficacy and safety have been developed in the last two decades. This expert review aimed to highlight the recent progress in AIT for both application routes, the sublingual (SLIT) and subcutaneous (SCIT) forms. As such, it covers recent aspects regarding efficacy and safety in clinical trials and real-life data and outlines new concepts in consensus and position papers as well as in guidelines for AIT...
October 29, 2018: Allergy
Song-I Yang, So-Yeon Lee, Hyo-Bin Kim, Hwan-Cheol Kim, Jong-Han Leem, Hyeon Jong Yang, Kwon Hyeok, Ju-Hee Seo, Hyun-Ju Cho, Jisun Yoon, Eun Lee, Young-Ho Jung, Yeongho Kim, Sungsu Jung, Ho-Jang Kwon, Soo-Jong Hong
BACKGROUND: The most relevant time of PM10 exposure to affect airway hyperresponsiveness (AHR) and new development of asthma in school-aged children is unclear. The aims of this study are to investigate the most critical time of PM10 exposure to affect AHR and new diagnosis of asthma from AHR in school-aged children. METHODS: Elementary schoolchildren (n=3570) has been enrolled in a nationwide prospective 4-year follow-up survey in Korea from 2005 to 2006. Individual annual PM10 exposure was estimated by using an ordinary kriging method from the prenatal period to 7 years of age...
October 29, 2018: Allergy
P Karisola, A Suomalainen, V Fortino, N Ottman, J Vendelin, H J Wolff, L Ruokolainen, D Greco, N Fyhrquist, H Alenius
No abstract text is available yet for this article.
October 29, 2018: Allergy
Judith L Thijs, Julia Drylewicz, Carla A F M Bruijnzeel-Koomen, Barbara Giovannone, Edward F Knol, Marjolein S de Bruin-Weller, Stefan Nierkens, DirkJan Hijnen
No abstract text is available yet for this article.
October 28, 2018: Allergy
Sophie Nicklaus, Amandine Divaret-Chauveau, Marie-Laure Chardon, Caroline Roduit, Vincent Kaulek, Eléa Ksiazek, Marie-Laure Dalphin, Anne M Karvonen, Pirkka Kirjavainen, Juha Pekkanen, Roger Lauener, Elisabeth Schmausser-Hechfellner, Harald Renz, Charlotte Braun-Fahrländer, Josef Riedler, Dominique A Vuitton, Erika Von Mutius, Jean-Charles Dalphin
BACKGROUND: The effect of exposure to micro-organisms on allergic diseases has been well studied. The protective effect of early food diversity against allergic diseases was previously shown in the PASTURE cohort study. The consumption of cheese, a food potentially rich in microbial diversity, deserves further examination. We aimed to evaluate whether cheese consumption is associated with allergic diseases. METHODS: In the PASTURE study (birth cohort in 5 European countries), data on feeding practices, environmental factors and allergic diseases were collected by questionnaires from birth to 6 years (N=931)...
October 28, 2018: Allergy
Huiyi Deng, Yueqi Sun, Weihao Wang, Meijiao Li, Tian Yuan, Weifeng Kong, Xuekun Huang, Zijie Long, Zhuanggui Chen, Deyun Wang, Qintai Yang
BACKGROUND: Hippo-Yes-associated protein (YAP) pathway plays an important role in epithelial cell proliferation and development. However, its possible role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unknown. We aim to investigate it on nasal epithelial proliferation and remodeling in CRSwNP. METHODS: The expressions of hippo pathway components as well as Ki-67 and E-cadherin in the sinonasal mucosa and nasal epithelial cells were analyzed in 14 controls, 14 eosinophilic CRSwNP and 14 non-eosinophilic CRSwNP...
October 26, 2018: Allergy
Giorgio Ciprandi, Michela Silvestri, Angela Pistorio, Maria Angela Tosca, Ignazio Cirillo
No abstract text is available yet for this article.
October 26, 2018: Allergy
Gopinath Kasetty, Ravi K V Bonghir, Praveen Papareddy, Ellen Tufvesson, Henning Stenberg, Leif Bjermer, Anna Hultgårdh-Nilsson, Heiko Herwald, Arne Egesten
BACKGROUND: In atopic asthma, chronic Th2-biased inflammation is associated with an increased risk of pneumococcal infection. The anionic phosphoglycoprotein osteopontin (OPN) is highly expressed in asthma and has been ascribed several roles during inflammation. This study aimed to investigate whether OPN affects inflammation and vulnerability to pneumococcal infection in atopic asthma. METHODS: House dust mite (HDM) extract was used to induce allergic airway inflammation in both wild-type (Spp1+/+ ) and OPN knockout (Spp1-/- ) C57BL/6J mice, and the airway was then infected with Streptococcus pneumoniae...
October 26, 2018: Allergy
Jiang-Qi Liu, Shan-Shan Li, Li-Hua Mo, Dian Yu, Xiao-Rui Geng, Jing-Yi Hong, Hai-Qiong Yu, Li-Teng Yang, Rui-Di Xie, Zhi-Qiang Liu, Zhi-Gang Liu, Ping-Chang Yang
No abstract text is available yet for this article.
October 25, 2018: Allergy
Marta Sacchetti, Marco Segatto, Alice Bruscolini, Irene Abicca, Carlo Cavaliere, Alessandro Lambiase
The involvement of neuro-inflammation has been demonstrated in asthma, allergic rhinitis (AR), conjunctivitis and atopic dermatitis. Allergic reaction is associated with local production and release of neuromediators such as Nerve Growth Factor (NGF), substance P and Calcitonine-gene related peptide. Patients with allergic diseases showed increased serum and local NGF levels during inflammation or after allergen challenge. This article is protected by copyright. All rights reserved.
October 24, 2018: Allergy
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