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Teresa Stemeseder, Eva Klinglmayr, Stephanie Moser, Lisa Lueftenegger, Roland Lang, Martin Himly, Gertie J Oostingh, Joerg Zumbach, Arne C Bathke, Thomas Hawranek, Gabriele Gadermaier
BACKGROUND: Allergen specific IgE antibodies are a hallmark of type I allergy. The aim of this cross-sectional study was to analyze the sensitization profiles of an Austrian adolescent population utilizing molecule-based IgE diagnosis. METHODS: Serum samples of 501 non-selected pupils from Salzburg, Austria, were tested in ImmunoCAP ISAC(®) for IgE reactivity to 112 single allergens. Sensitization profiles were assessed and statistically coordinated with reported allergies...
October 18, 2016: Allergy
A Heratizadeh, T Werfel
The pathogenesis of atopic dermatitis (AD) is multi-factorial and complex. Consequently, clinical signs and symptoms vary strongly depending on individually relevant trigger factors and the stage of the disease. So far, treatment of AD was commonly limited to topical treatment or, in more severe cases, to systemic drugs mostly approved for other indications than AD. However, emerging data on new anti-inflammatory agents have been published in the recent years. As these new substances specifically focus on immune responses in AD, these are partially considered as possible "break-through" in the treatment of AD...
October 13, 2016: Allergy
Paul C Schröder, Sabina Illi, Vera I Casaca, Anna Lluis, Andreas Böck, Caroline Roduit, Martin Depner, Remo Frei, Jon Genuneit, Petra Ina Pfefferle, Marjut Roponen, Juliane Weber, Charlotte Braun-Fahrländer, Josef Riedler, Jean-Charles Dalphin, Juha Pekkanen, Roger Lauener, Erika von Mutius, Bianca Schaub, Anne Hyvärinen, Anne M Karvonen, Maija-Riitta Hirvonen, Pekka Tiittanen, Sami Remes, Vincent Kaulek, Marie-Laure Dalphin, Markus J Ege, Georg J Loss, Harald Renz, Gert Doekes, Michael Kabesch
BACKGROUND: Farm exposure protects against development of allergies early in life. At 4.5 years, protection against asthma by farm-milk exposure was partially mediated by regulatory T-cells (Tregs). The aim of this study was to investigate the critical time window of the "asthma-protective" farm effect via Tregs during childhood immune maturation. METHODS: Tregs were assessed longitudinally at 4.5 and 6 years in 111 children (56 farm, 55 reference children) from the PASTURE/EFRAIM birth cohort (flow-cytometry)...
October 12, 2016: Allergy
José Serrano-Pariente, Vicente Plaza, Joan B Soriano, Mercè Mayosc, Antolín López-Viña, César Picado, Laura Vigil
BACKGROUND: Continuous positive airway pressure (CPAP) in asthma patients with concomitant obstructive sleep apnea syndrome (OSAS) seems to have a favorable impact on asthma, but data are inconsistent due to methodological limitations of previous studies METHODS: Prospective, multicenter study. We examined asthma outcomes after six months of CPAP in 99 adult asthma patients (mean age 57 years) with OSAS (respiratory disturbance index ≥20). Asthma control and quality of life were assessed with the Asthma Control Questionnaire (ACQ) and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), respectively...
October 12, 2016: Allergy
G Cortellini, A Romano, A Santucci, A Barbaud, S Bavbek, D Bignardi, M Blanca, P Bonadonna, M T Costantino, J J Laguna, C Lombardo, L Losappio, J Makowska, A Nakonechna, O Quercia, E A Pastorello, V Patella, I Terreehorst, S Testi, J R Cernadas, J Dionicio Elera, D Lippolis, S Voltolini, D Grosseto
BACKGROUND: Hypersensitivity to acetylsalicylic acid (ASA) constitutes a serious problem for subjects with coronary artery disease. In such subjects, physicians have to choose the more appropriate procedure between challenge and desensitization. As the literature on this issue is sparse, the present study aims to establish in these subjects clinical criteria for eligibility for an ASA challenge and/or desensitization. METHODS: Collection and analysis of data on ASA challenges and desensitizations from 10 allergy centers, as well as consensus among the related physicians and an expert panel...
October 12, 2016: Allergy
Moisés A Calderón, Carmen Vidal, Pablo Rodríguez Del Río, Jocelyne Just, Oliver Pfaar, Ana I Tabar, Inmaculada Sánchez-Machín, Petra Bubel, Jesus Borja, Peter Eberle, Rainer Reiber, Michel Bouvier, Alain Lepelliez, Ludger Klimek, Pascal Demoly
BACKGROUND: Outside clinical trials, data on systemic reactions (SRs) due to allergen immunotherapy (AIT) are scarce. METHODS: A prospective, longitudinal, web-based survey of "real-life" respiratory allergen immunotherapy (AIT) clinical practice was conducted in France, Germany and Spain. SRs were recorded and coded according to the Medical Dictionary for Regulatory Activities (MedDRA) and risk factors associated with SRs were identified. RESULTS: A total of 4,316 patients (corresponding to 4,363 ongoing courses of AIT) were included...
October 8, 2016: Allergy
Alicia R Mathers, Cara D Carey, Meaghan E Killeen, Julio Diaz-Perez, Sonia R Salvatore, Francisco J Schopfer, Bruce A Freeman, Louis D Falo
BACKGROUND: Reactions between nitric oxide (NO), nitrite (NO2(-) ), and unsaturated fatty acids give rise to electrophilic nitro-fatty acids (NO2 -FAs), such as nitro-oleic acid (OA-NO2 ) and nitro-linoleic acid (LNO2 ). Endogenous electrophilic fatty acids (EFAs) mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction reactions. Hence, there is considerable interest in employing NO2 -FAs and other EFAs for the prevention and treatment of inflammatory disorders...
October 8, 2016: Allergy
Thomas Bieber, Stefan Vieths, Karl Broich
Atopic conditions (atopic dermatitis, rhinitis and asthma) belong to the most common non communicable diseases and are driven by chronic inflammatory reactions. They have a strong impact on the quality of life and represent a substantial and growing socio-economic burden. Interestingly, there is an increasing interest in the development of new therapeutic options with a number of biologics and small molecules targeting potential key mechanisms in atopic conditions. However, besides the safety issue, most of the new active substances are still evaluated according to the traditional efficacy paradigm focusing on the success in treating exacerbations and flares...
October 7, 2016: Allergy
Sarah S Killingbeck, Moyar Q Ge, Angela Haczku
Immunotherapy has been employed with great success in the form of vaccination to combat viral, bacterial, and parasitic infection. In this issue of Allergy, Cabauatan et al. describe a novel method of allergen specific immunotherapy using epicutaneous patch vaccination with the recombinant birch pollen antigen Bet v 1 in combination with a heat-labile Escherichia coli toxin (LT) as adjuvant. Patch vaccination with rBet v 1 + LT augmented production of IgG instead of IgE antibodies, inhibiting rBet v 1 sensitization in outbred guinea pigs...
October 7, 2016: Allergy
Fabian Zellweger, Alexander Eggel
IgE-associated allergic diseases belong to the most common inflammatory conditions. Their clinical manifestation ranges from mild symptoms to life-threatening episodes. Often patients experience a reduction in physical and psychologic well-being and suffer from a decreased quality-of-life due to disease activity. The continuously rising number of people that are affected by an allergic condition indicates an urgent need for better diagnostics and more efficient treatment options. Recent progress in the understanding of pathophysiologic mechanisms underlying IgE-associated allergic disorders have led to the identification of novel therapeutic targets and the development of drug candidates that are currently under evaluation...
October 6, 2016: Allergy
M A E Nieuwenhuis, J M Vonk, B E Himes, C Sarnowski, C Minelli, D Jarvis, E Bouzigon, D C Nickle, M Laviolette, D Sin, S T Weiss, M van den Berge, G H Koppelman, D S Postma
BACKGROUND: The severity of bronchial hyperresponsiveness (BHR) is a fundamental feature of asthma. The severity of BHR varies between asthmatics and is associated with lack of asthma control. The mechanisms underlying this trait are still unclear. This study aims to identify genes associated with BHR severity, using a genome wide association study (GWAS) on the slope of BHR in adult asthmatics. METHODS: We performed a GWAS on BHR severity in adult asthmatics from the Dutch Asthma GWAS cohort (n=650), adjusting for smoking and inhaled corticosteroid use, and verified results in 3 other cohorts...
October 6, 2016: Allergy
A K A Wright, C Newby, R A Hartley, V Mistry, S Gupta, R Berair, K M Roach, R Saunders, T Thornton, M Shelley, K Edwards, B Barker, C E Brightling
BACKGROUND: The role of fibrocytes in COPD is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease. METHODS: Utilising flow cytometry to identify circulating, collagen type-1(+) cells we found two populations 1) CD45(+) CD34(+) (fibrocytes) and 2) CD45(+) CD34(-) (myeloid-derived suppressor cell [MDSC]-like fibrocytes) cells in stable COPD (n=41) and control (n=29) subjects...
October 6, 2016: Allergy
Y Mostmans, M Grosber, M Blykers, P Mols, N Naeije, J Gutermuth
BACKGROUND: Anaphylaxis is a life-threatening emergency of which reliable epidemiological data are lacking. This study aimed to analyze how quickly patients presenting with anaphylaxis were treated in emergency and whether treatment followed the EAACI-guidelines. METHODS: Patient data were collected between 04/2009-04/2013. Emergency doctors completed a questionnaire for adult patients presenting at the emergency department (ED) of the St. Pierre hospital in Brussels with anaphylaxis...
October 6, 2016: Allergy
M A Portelli, C Moseley, C E Stewart, D S Postma, P Howarth, J A Warner, J W Holloway, G H Koppelman, C Brightling, I Sayers
RATIONALE: Genetic polymorphisms in the asthma susceptibility gene, urokinase plasminogen activator receptor (uPAR/PLAUR) have been associated with lung function decline and uPAR blood levels in asthma subjects. Preliminary studies have identified uPAR elevation in asthma; however, a definitive study regarding which clinical features of asthma uPAR may be driving is currently lacking. OBJECTIVES: We aimed to comprehensively determine the uPAR expression profile in asthma and control subjects utilizing bronchial biopsies and serum, and to relate uPAR expression to asthma clinical features...
October 5, 2016: Allergy
M Pollock, I P Sinha, L Hartling, B H Rowe, S Schreiber, R M Fernandes
International guidelines provide conflicting recommendations on how to use bronchodilators to manage childhood acute wheezing conditions in the emergency department (ED), and there is variation within and among countries in how these conditions are managed. This may be reflective of uncertainty about the evidence. This overview of systematic reviews (SRs) aimed to synthesize, appraise, and present all SR evidence on the efficacy and safety of inhaled short-acting bronchodilators to treat asthma and wheeze exacerbations in children 0-18 years presenting to the ED...
October 5, 2016: Allergy
Lara Ravanetti, Annemiek Dijkhuis, Yanaika S Sabogal Pineros, Suzanne M Bal, Barbara S Dierdorp, Tamara Dekker, Adrian Logiantara, Ian M Adcock, Navin L Rao, Louis Boon, Gino Villetti, Peter J Sterk, Fabrizio Facchinetti, René Lutter
BACKGROUND: Acute worsening of asthma symptoms (exacerbation) is predominantly triggered by respiratory viruses, with influenza causing the most severe exacerbations. The lack of an adequate animal model hampers mechanistic insight and the development of new therapeutics. AIM: We developed and characterized a robust, consistent and reproducible mouse model of severe exacerbation of chronic allergic asthma. METHODS: Chronic allergic airway inflammation was induced following a house dust mite (HDM)-sensitization protocol...
October 3, 2016: Allergy
Antonella Muraro, Brecht Steelant, Sirpa Pietikainen, David Borrelli, Nessa Childers, Ina Callebaut, Inge Kortekaas Krohn, Katleen Martens, Benoit Pugin, Florin Dan-Popescu, Mariana Vieru, Marek Jutel, Ioana Agache, Peter W Hellings
From the 26th to the 28th of April 2016, an allergy awareness campaign was organized by the European Academy of Allergy and Clinical Immunology (EAACI) and the European Federation of Allergy and Airway Diseases Patients Associations (EFA) in the European Parliament in Brussels, with support of the European Parliament's Interest group on Allergy and Asthma and was co-hosted by the Members of the European Parliament (MEP) David Borrelli, Sirpa Pietikainen and Nessa Childers. Skin prick tests (SPT) were performed to gain attention for the increasing prevalence of allergic airways diseases in Europe...
October 3, 2016: Allergy
J B Wartna, A M Bohnen, G Elshout, M W H Pijnenburg, D H J Pols, R R Gerth van Wijk, P J E Bindels
BACKGROUND: About 12% of children are affected by allergic rhinoconjunctivitis (AR). Although the main symptomatic treatments are intranasal corticosteroids (INCS) (daily or on demand) and oral antihistamines, it remains unclear which treatment provides the best relief of symptoms. Therefore, this study examines whether daily use of INCS is superior to on demand use, or to oral antihistamines on demand. METHODS: A single-blinded randomized controlled trial in children (aged 6-18 years) with pollen-related AR...
October 3, 2016: Allergy
L B Grabenhenrich, A Reich, J Bellach, V Trendelenburg, A B Sprikkelman, G Roberts, K E C Grimshaw, S Sigurdardottir, M L Kowalski, N G Papadopoulos, S Quirce, R Dubakiene, B Niggemann, M Fernández-Rivas, B Ballmer-Weber, R van Ree, S Schnadt, E N C Mills, T Keil, K Beyer
BACKGROUND: The conduct of oral food challenges as the preferred diagnostic standard for food allergy (FA) was harmonized over the last years. However, documentation and interpretation of challenge results, particularly in research settings, are not sufficiently standardized to allow valid comparisons between studies. Our aim was to develop a diagnostic toolbox to capture and report clinical observations in double-blind placebo-controlled food challenges (DBPCFC). METHODS: A group of experienced allergists, paediatricians, dieticians, epidemiologists and data managers developed generic case report forms and standard operating procedures for DBPCFCs and piloted them in three clinical centres...
September 27, 2016: Allergy
L Polloni, E Ferruzza, L Ronconi, A Toniolo, F Lazzarotto, R Bonaguro, N Celegato, A Muraro
BACKGROUND: Inappropriate dietary eliminations may impair quality of life, affect children's growth and unnecessarily impact on healthcare costs. Previous retrospective studies reported that around 25% of children continue a food-avoidance diet despite a negative oral food challenge (OFC). A definite pattern has not been found yet for patients not reintroducing the food. This study aimed to examine the role of child's nutritional attitudes and maternal anxiety in reintroducing food after a negative OFC...
September 23, 2016: Allergy
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