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AIDS Patient Care and STDs

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https://www.readbyqxmd.com/read/28051875/a-health-related-quality-of-life-measure-for-use-in-patients-with-hiv-a-validation-study
#1
Rebecca Schnall, Jianfang Liu, Hwayoung Cho, Sabina Hirshfield, Karolynn Siegel, Susan Olender
In the United States, HIV has evolved from an acute disease to a chronic illness making health-related quality of life a pre-eminent goal for many persons living with HIV (PLWH). There have been a number of HIV-specific quality-of-life instruments developed, but little attention has been paid to the validation of standardized nondisease-specific quality-of-life instruments tailored to PLWH. The goal of this research was to validate the Patient-Reported Outcomes Measurement Information System (PROMIS)-29, a questionnaire that measures health-related quality of life in PLWH...
January 4, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27936863/missed-opportunities-for-repeat-hiv-testing-in-pregnancy-implications-for-elimination-of-mother-to-child-transmission-in-the-united-states
#2
Caiyun Liao, William Christopher Golden, Jean R Anderson, Jenell S Coleman
HIV testing is an effective intervention that is used for reducing perinatal HIV transmission. Centers for Disease Control and Prevention recommends a second HIV test during the third trimester of pregnancy for women in settings with an elevated HIV incidence (≥17 cases per 100,000 person-years). We conducted a retrospective cohort study at a single hospital in Baltimore, Maryland, to determine whether a second HIV test was done and to compare HIV retesting with mandated syphilis retesting. Of women who delivered at this hospital, 98...
December 12, 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28051898/high-proportion-of-deaths-attributable-to-hiv-among-postpartum-women-in-botswana-despite-widespread-uptake-of-antiretroviral-therapy
#3
Rebecca Marie Zash, Sajini Souda, Jean Leidner, Kelebogile Binda, Chazha Hick, Kathleen Powis, Joseph Makhema, Mompati Mmalane, Max Essex, Shahin Lockman, Roger L Shapiro
Mortality in the postpartum period may be impacted by antiretroviral therapy (ART) received in pregnancy, and whether ART is continued in the postpartum period. HIV-infected and HIV-uninfected mothers were enrolled within 48 h of delivery at five public hospital maternity wards throughout Botswana and followed for 24 months. Maternal deaths were reported by one of the approved contacts given by the mother at enrollment. Detailed information on the cause of death was not available. Risk factors for 24-month mortality were assessed using Cox proportional hazard models...
January 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28051897/prevalence-of-metabolic-syndrome-among-people-living-with-hiv-in-developing-countries-a-systematic-review
#4
Sivaraj Naidu, Sasheela Ponnampalvanar, Shahrul Bahyah Kamaruzzaman, Adeeba Kamarulzaman
Metabolic syndrome (MS) is a group of components associated with cardiovascular disease and type 2 diabetes mellitus. The prevalence of MS in the HIV population is increasing in epidemic proportions globally. However, the magnitude and characteristics of MS are not fully elucidated in developing countries. The aim of this systematic review was to assess the prevalence of MS and its components among people living with HIV (PLWH) in developing countries. Searches were carried out in MEDLINE, Embase, Web of Science, CINAHL, Cochrane Central Register of Controlled Trials, Scopus, other web sources, and by hand search...
January 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28051896/optimizing-the-timing-of-hiv-screening-as-part-of-routine-medical-care
#5
Matthew R Golden, James P Hughes, Julia C Dombrowski
US federal guidelines recommend that medical providers test all adolescents and adults for HIV infection at least once before the age of 64. The wide age range included in these guidelines may limit their utility and impact. We created an arithmetic model to estimate how HIV screening at different ages would impact the total number of years of undiagnosed HIV infection in the population and the number of persons developing clinical manifestations of HIV/AIDS. Our base case model assumed that age of infection in the screened population was the same as the estimated age of infection among all persons diagnosed with HIV in the United States in 2010...
January 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28051895/correction-to-aids-patient-care-and-stds-2016-30-425-434-doi-10-1089-apc-2016-0114
#6
(no author information available yet)
No abstract text is available yet for this article.
January 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27893276/opportunities-for-hiv-prevention-communication-during-sexual-encounters-with-black-men-who-have-sex-with-men
#7
Tiffiany M Aholou, Jose Nanin, Kathryn Drumhiller, Madeline Y Sutton
Conversations about HIV prevention before engaging in sex may result in safer sex practices and decreased HIV transmission. However, partner communication for HIV prevention has been understudied among black/African American men who have sex with men (BMSM), a group that is disproportionately affected by HIV. We explored and described encounters and perceptions about HIV prevention conversations among BMSM and their sex partner(s) in New York City. We conducted an inductive thematic analysis of semi-structured interviews with BMSM who reported sex with a man in the previous 3 months...
January 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27905841/cell-delivered-entry-inhibitors-for-hiv-1-ccr5-downregulation-and-blocking-virus-membrane-fusion-in-defending-the-host-cell-population
#8
Geoff Symonds, Jeffrey S Bartlett, Hans-Peter Kiem, Marlene Tsie, Louis Breton
HIV-1 infection requires the presence of the CD4 receptor on the target cell surface and a coreceptor, predominantly CC-chemokine receptor 5 (CCR5). It has been shown that individuals who are homozygous for a defective CCR5 gene are protected from HIV-1 infection. A novel self-inactivating lentiviral vector LVsh5/C46 (Cal-1) has been engineered to block HIV-1 infection with two viral entry inhibitors, conferring resistance to HIV-1 infection from both CCR5 and CXCR4 tropic strains. Cal-1 encodes a short hairpin RNA (sh5) to downregulate CCR5 and C46, an HIV-1 fusion inhibitor...
December 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27905840/combining-cell-and-gene-therapy-in-an-effort-to-eradicate-hiv
#9
Thor A Wagner
More than 30 million people are infected with HIV, and HIV remains the fifth leading cause of disability-adjusted life years worldwide. Antiretroviral therapy (ART) dramatically decreases mortality rate, but there are side effects, long-term toxicities, expenses, stigmas, and inconveniences associated with chronic treatment, and HIV-infected individuals on ART have an increased risk of malignancies, cardiovascular disease, neurologic disease, and shortened life expectancy. Therefore, a cure for HIV remains an important goal...
December 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27905839/gene-therapy-to-cure-hiv-where-to-from-here
#10
Rowena Johnston
A variety of approaches are being tested to cure HIV, but with the exception of the Berlin patient case, none has been successful. The Berlin patient, positive for both HIV and acute myeloid leukemia (AML), received two stem cell transplants from a donor homozygous for the CCR5delta32 mutation. In the 8 years since his second transplant, he has remained free of both HIV and AML. This case provides strong proof-of-principle that a cure for HIV is possible and might be achieved through gene therapy. Several technological barriers must be resolved and are discussed here, including the safe delivery of the intervention throughout the body of the infected person, increased efficiency of gene editing, and avoidance of resistance to the therapy...
December 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27905838/engineering-hiv-specific-immunity-with-chimeric-antigen-receptors
#11
Scott G Kitchen, Jerome A Zack
HIV remains a highly important public health and clinical issue despite many recent advances in attempting to develop a cure, which has remained elusive for most people infected with HIV. HIV disease can be controlled with pharmacologic therapies; however, these treatments are expensive, may have severe side effects, and are not curative. Consequently, an improved means to control or eliminate HIV replication is needed. Cytotoxic T lymphocytes (CTLs) play a critical role in controlling viral replication and are an important part in the ability of the immune response to eradicate most viral infections...
December 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27855263/disruption-or-excision-of-provirus-as-an-approach-to-hiv-cure
#12
Keith R Jerome
An effective approach to HIV cure will almost certainly require a combination of strategies, including some means of reducing the latent HIV reservoir. Because the integrated HIV provirus represents the major source of viral persistence and reactivation, one attractive approach is the direct targeting of provirus for disruption or excision using targeted endonucleases, such as CRISPR/Cas9, zinc finger nucleases, TAL effector nucleases, or meganucleases (homing endonucleases). This article highlights some of the challenges for successful endonuclease therapy for HIV, including optimization of enzyme activity and specificity, the possible emergence of viral resistance, and most importantly, efficient in vivo delivery of the enzymes to a sufficient portion of the latent reservoir...
December 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27854121/a-cure-for-aids
#13
Jeffrey Laurence
No abstract text is available yet for this article.
December 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27854119/clinical-applications-of-genome-editing-to-hiv-cure
#14
Cathy X Wang, Paula M Cannon
Despite significant advances in HIV drug treatment regimens, which grant near-normal life expectancies to infected individuals who have good virological control, HIV infection itself remains incurable. In recent years, novel gene- and cell-based therapies have gained increasing attention due to their potential to provide a functional or even sterilizing cure for HIV infection with a one-shot treatment. A functional cure would keep the infection in check and prevent progression to AIDS, while a sterilizing cure would eradicate all HIV viruses from the patient...
December 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27849373/adaptation-and-implementation-of-an-intervention-to-reduce-hiv-related-stigma-among-healthcare-workers-in-the-united-states-piloting-of-the-fresh-workshop
#15
D Scott Batey, Samantha Whitfield, Mazheruddin Mulla, Kristi L Stringer, Modupeoluwa Durojaiye, Lisa McCormick, Bulent Turan, Laura Nyblade, Mirjam-Colette Kempf, Janet M Turan
HIV-related stigma has been shown to have profound effects on people living with HIV (PLWH). When stigma is experienced in a healthcare setting, negative health outcomes are exacerbated. We sought to assess the feasibility and acceptability of a healthcare setting stigma-reduction intervention, the Finding Respect and Ending Stigma around HIV (FRESH) Workshop, in the United States. This intervention, adapted from a similar strategy implemented in Africa, brought together healthcare workers (HW) and PLWH to address HIV-related stigma...
November 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27849372/using-path-analysis-to-evaluate-the-healthcare-empowerment-model-among-persons-living-with-hiv-for-antiretroviral-therapy-adherence
#16
Jacob J van den Berg, Torsten B Neilands, Mallory O Johnson, Bing Chen, Parya Saberi
Healthcare empowerment (HCE) is patient controlled and includes the process and state of being engaged, informed, collaborative, committed, and tolerant of uncertainty. Understanding psychosocial factors that impact HCE for persons living with HIV is critical for their treatment and care. A sample of 1494 male and female participants living with HIV in the United States with a mean age of 45.6 (standard deviation = 11.4) completed a one-time online survey about their demographic characteristics, social support, healthcare provider relationship, HIV treatment knowledge, perceived HIV-related stigma, lifetime trauma, depressive symptoms, HCE, and antiretroviral therapy (ART) adherence...
November 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27849371/determinants-of-behavior-change-intention-among-heterosexual-thai-males-diagnosed-with-sexually-transmitted-diseases
#17
Ratsiri Thato, Ekkachai Daengsaard
This study sought to identify factors associated with intention to change sexual practices among heterosexual Thai males diagnosed with sexually transmitted infections (STIs). STI clinic patients (n = 247) reported their sexual behaviors and condom use during the previous 3 months. STI and HIV knowledge, motivation to change sexual practices, and behavioral skills were assessed. Then, self-reported behavior change intention, including consistent condom use, reducing number of sexual partners, not using drugs and alcohol when having sex, and refusal of condomless sex, was examined...
November 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27849370/reengagement-in-care-after-a-gap-in-hiv-care-among-a-population-of-privately-insured-persons-with-hiv-in-the-united-states
#18
Kathy K Byrd, Melissa Furtado, Tim Bush, Lytt Gardner
The HIV care continuum illustrates steps needed to reach HIV viral suppression, including retention in care. The continuum's retention measure does not account for gaps or reengagement in care and thus provides an incomplete picture of long-term engagement. We used a claims database to determine the proportion of privately insured persons with HIV who experienced a gap in care and subsequently reengaged between 2008 and 2012. A gap was defined as no office visit claim in >6 months and reengagement as ≥1 office visit claim after a gap...
November 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27849369/understanding-barriers-to-scaling-up-hiv-assisted-partner-services-in-kenya
#19
Marielle Goyette, Beatrice Muthoni Wamuti, Mercy Owuor, David Bukusi, Peter Mutiti Maingi, Felix Abuna Otieno, Peter Cherutich, Anne Ng'ang'a, Carey Farquhar
Assisted partner services (APS) are more effective than passive referral in identifying new cases of HIV in many settings. Understanding the barriers to the uptake of APS in sub-Saharan Africa is important before its scale up. In this qualitative study, we explored client, community, and healthcare worker barriers to APS within a cluster randomized trial of APS in Kenya. We conducted 20 in-depth interviews with clients who declined enrollment in the APS study and 9 focus group discussions with health advisors, HIV testing and counseling (HTC) counselors, and the general HTC client population...
November 2016: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/27849368/correction-to-aids-patient-care-and-stds-2015-29-4-12-doi-10-1089-apc-2014-0166
#20
(no author information available yet)
No abstract text is available yet for this article.
November 2016: AIDS Patient Care and STDs
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