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AIDS Patient Care and STDs

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https://www.readbyqxmd.com/read/29232170/correlates-of-never-testing-for-hiv-among-sexually-active-internet-recruited-gay-bisexual-and-other-men-who-have-sex-with-men-in-the-united-states
#1
Kimberly M Nelson, David W Pantalone, Kristi E Gamarel, Michael P Carey, Jane M Simoni
In the United States, gay, bisexual, and other men who have sex with men (GBMSM) are disproportionately affected by the HIV/AIDS epidemic. Despite great strides in HIV prevention, including biobehavioral HIV prevention strategies such as pre-exposure prophylaxis and treatment as prevention, there has been relatively low uptake of these strategies. The success of biobehavioral prevention strategies requires HIV testing but a subset of GBMSM have never been tested. To optimize prevention efforts, we sought to understand the characteristics of GBMSM who report never testing for HIV...
December 12, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29185801/the-pre-exposure-prophylaxis-prep-stigma-paradox-learning-from-canada-s-first-wave-of-prep-users
#2
Daniel Grace, Jody Jollimore, Paul MacPherson, Matthew J P Strang, Darrell H S Tan
With the emergence of daily oral tenofovir disoproxil fumarate and emtricitabine-based pre-exposure prophylaxis (PrEP) use in Canada, questions have emerged concerning the impacts of this HIV prevention tool on gay men's social and sexual lives. We conducted small focus groups and individual qualitative interviews with 16 gay men in Toronto who were part of the 'first wave' of Canadian PrEP users. Participants were on PrEP for at least one year as part of a demonstration project (November 2014-June 2016). These participants accessed PrEP before regulatory approval by Health Canada in February 2016...
November 29, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29148966/exploring-the-health-care-environment-and-associations-with-clinical-outcomes-of-people-living-with-hiv-aids
#3
Mary Hawk, Robert W S Coulter, James E Egan, Mackey Reuel Friedman, Steven Meanley, Stuart Fisk, Courtney Watson, Suzanne Kinsky
Despite three decades of dramatic treatment breakthroughs in antiretroviral regimens, clinical outcomes for people living with HIV vary greatly. The HIV treatment cascade models the stages of care that people living with HIV go through toward the goal of viral suppression and demonstrates that <30% of those living with HIV/AIDS in the United States have met this goal. Although some research has focused on the ways that patient characteristics and patient-provider relationships contribute to clinical adherence and treatment success, few studies to date have examined the ways that contextual factors of care and the healthcare environment contribute to patient outcomes...
November 17, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29323558/optimizing-delivery-of-hiv-preexposure-prophylaxis-for-women-in-the-united-states
#4
Erika Aaron, Cori Blum, Dominika Seidman, Mary Jo Hoyt, Joanne Simone, Meg Sullivan, Dawn K Smith
Preexposure prophylaxis (PrEP) is a highly effective HIV prevention method; however, it is underutilized among women who are at risk for acquisition of HIV. Women comprise one in five HIV diagnoses in the United States, and significant racial disparities in new HIV diagnoses persist. The rate of new HIV diagnoses among black and African American women in 2015 was 16 times greater than that of white women. These disparities highlight the importance of HIV prevention strategies for women, including the use of PrEP...
January 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29323557/neuropsychological-assessment-of-412-hiv-infected-individuals-in-s%C3%A3-o-paulo-brazil
#5
Maria Rita Polo Gascón, José Ernesto Vidal, Yolanda Marques Mazzaro, Jerusa Smid, Rosa Maria Nascimento Marcusso, Claudio Garcia Capitão, Elizeu Macedo Coutinho, Glaucia Rosana Guerra Benute, Mara Cristina Souza De Lucia, Augusto César Penalva de Oliveira
HIV-associated neurocognitive disorders (HAND) remain frequent even among individuals receiving combined antiretroviral therapy (cART). In addition, HAND may adversely affect the quality of life and adherence to cART. There is scarce epidemiological information about HAND in Latin America. This cross-sectional study recruited HIV-infected patients from a tertiary teaching institution in São Paulo, Brazil, between May 2013 and February 2015. The patients were adults with at least 4 years of education and patients with current neurological or psychiatric diseases were excluded...
January 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29323556/modality-of-primary-hiv-disclosure-and-association-with-mental-health-stigma-and-antiretroviral-therapy-adherence-in-tanzanian-youth-living-with-hiv
#6
Julia V Ramos, Blandina T Mmbaga, Elizabeth L Turner, Leonia L Rugalabamu, Severa Luhanga, Coleen K Cunningham, Dorothy E Dow
Disclosing HIV status to children before adolescence is a major challenge facing families and healthcare providers. This study used a mixed methods approach to explore the youth perspective of how youth living with HIV (YLHIV) found out their status and to quantify the association of disclosure modality with mental health, stigma, adherence, and HIV outcomes in adolescence. Youth 11-24 years of age attending adolescent HIV clinic in Moshi, Tanzania were included. Adolescents answered questions, including when and how they found out they had HIV, mental health surveys (nine-item Patient Health Questionnaire, Strengths and Difficulties Questionnaire, and modified University of California Los Angeles trauma screen), modified Berger's stigma scale, and self-reported adherence...
January 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29211515/factors-associated-with-use-of-short-term-pre-exposure-prophylaxis-for-hiv-among-female-partners-of-migrant-miners-in-mozambique
#7
Joana Falcao, Allison Zerbe, Maria Lahuerta, Rachel Baggaley, Laurence Ahoua, Pietro DiMattei, Fernando Morales, Isaias Ramiro, Wafaa M El-Sadr
Effective interventions tailored to specific types of behaviors and contexts are needed for women at risk for HIV acquisition. Oral pre-exposure prophylaxis (PrEP) is an efficacious HIV prevention intervention that uses antiretroviral drugs to reduce the risk of acquiring HIV infection. In Mozambique, HIV remains a major public health concern, with a national prevalence of 13%. Studies have demonstrated that the migration of male miners between southern provinces of Mozambique and South Africa is contributing to the HIV epidemic in Mozambique...
December 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29211514/hiv-care-providers-intentions-to-prescribe-and-actual-prescription-of-pre-exposure-prophylaxis-to-at-risk-adolescents-and-adults
#8
Tanya L Kowalczyk Mullins, Gregory Zimet, Michelle Lally, Jiahong Xu, Sarah Thornton, Jessica A Kahn
Pre-exposure prophylaxis (PrEP) is indicated for use in US adults, and little is known about clinician intentions to prescribe and actual prescription of PrEP to adolescents younger than 18. Fifty-six clinicians who care for HIV-infected and at-risk youth completed an anonymous online survey in 2014. Primary outcomes were (1) intentions to prescribe PrEP to adolescents and adults in four risk categories [men who have sex with men (MSM), transgender women, heterosexuals with multiple partners of unknown HIV status, heterosexuals with HIV-infected partners]; and (2) actual prescription of PrEP to adolescents and adults in these risk groups...
December 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29211513/facilitators-and-barriers-to-pre-exposure-prophylaxis-willingness-among-young-men-who-have-sex-with-men-who-use-geosocial-networking-applications-in-california
#9
Ian W Holloway, Diane Tan, Jennifer L Gildner, Sean C Beougher, Craig Pulsipher, Jorge A Montoya, Aaron Plant, Arleen Leibowitz
While correlates of pre-exposure prophylaxis (PrEP) uptake have been explored among older men who have sex with men (MSM), less is known about the facilitators and barriers that encourage uptake among younger MSM (YMSM). This study explores the association between willingness to take PrEP and demographic characteristics, sexual risk, and substance use, and attitudinal factors among YMSM in California who use geosocial networking applications (GSN apps). Based on survey data from YMSM recruited through GSN apps (n = 687), PrEP willingness was positively associated with Hispanic ethnicity [adjusted odds ratio (aOR): 1...
December 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29211512/durability-of-second-antiretroviral-regimens-in-the-italian-cohort-naive-antiretrovirals-foundation-study-and-factors-associated-with-discontinuation
#10
Antonio Di Biagio, Patrizia Lorenzini, Giulia Gustinetti, Stefano Rusconi, Andrea De Luca, Giuseppe Lapadula, Sergio Lo Caputo, Stefania Cicalini, Francesco Castelli, Giulia Marchetti, Andrea Antinori, Antonella d'Arminio Monforte
The study was designed to investigate the median duration of second antiretroviral regimens and factors associated with early discontinuation in HIV patients who switched with an undetectable viral load. We conducted a retrospective analysis of the Italian Cohort Naive Antiretrovirals Foundation Study (ICONA), which collects data throughout the country. Patients who started first antiretroviral therapy (ART) after January 1, 2008 in any center involved in this cohort and then switched to a second regimen were included in the study...
December 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29087746/underutilization-of-statins-when-indicated-in-hiv-seropositive-and-seronegative-women
#11
Jonathan V Todd, Stephen R Cole, David A Wohl, Ross J Simpson, Michele Jonsson Funk, M Alan Brookhart, Jennifer Cocohoba, Daniel Merenstein, Anjali Sharma, Jason Lazar, Joel Milam, Mardge Cohen, Stephen Gange, Tené T Lewis, Greer Burkholder, Adaora A Adimora
Increased life expectancy of persons living with HIV infection receiving antiretroviral therapy heightens the importance of preventing and treating chronic comorbidities such as cardiovascular disease. While guidelines have increasingly advocated more aggressive use of statins for low-density lipoprotein (LDL) cholesterol reduction, it is unclear whether people with HIV, especially women, are receiving statins when indicated, and whether their HIV disease is a factor in access. We assessed the cumulative incidence of statin use after an indication in the Women's Interagency HIV Study (WIHS), from 2000 to 2014...
November 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29087745/substantially-higher-and-earlier-occurrence-of-anti-tuberculosis-drug-related-adverse-reactions-in-hiv-coinfected-tuberculosis-patients-a-matched-cohort-study
#12
Takashi Matono, Takeshi Nishijima, Katsuji Teruya, Eriko Morino, Jin Takasaki, Hiroyuki Gatanaga, Yoshimi Kikuchi, Mitsuo Kaku, Shinichi Oka
Little information exists on the frequency, severity, and timing of first-line anti-tuberculosis drug-related adverse events (TB-AEs) in HIV-tuberculosis coinfected (HIV-TB) patients in the antiretroviral therapy (ART) era. This matched-cohort study included HIV-TB patients as cases and HIV-uninfected tuberculosis (non-HIV-TB) patients as controls. Tuberculosis was culture-confirmed in both groups. Cases were matched to controls in a 1:4 ratio on age, sex, and year of diagnosis. TB-AEs were defined as Grade 2 or higher requiring drug discontinuation/regimen change...
November 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29087744/potential-healthcare-insurance-and-provider-barriers-to-pre-exposure-prophylaxis-utilization-among-young-men-who-have-sex-with-men
#13
Sarah J Marks, Roland C Merchant, Melissa A Clark, Tao Liu, Joshua G Rosenberger, Jose Bauermeister, Kenneth H Mayer
Young adult men-who-have-sex-with-men (YMSM) continue to have among the highest incidence of HIV infection in the United States. Pre-exposure prophylaxis (PrEP) is an effective and safe method of preventing HIV infection; however, despite US Food and Drug Administration approval, utilization remains low, in part, due to structural barriers, particularly access to healthcare. In this study, we used social media to recruit black, Hispanic, and white HIV-uninfected 18- to 24-year-old YMSM. Participants completed an online survey about their sexual behavior, healthcare access, and previous use of PrEP...
November 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29087743/experiences-of-young-parents-with-perinatally-acquired-hiv
#14
Cynthia Fair, Hannah Allen, Connie Trexler, Lawrence J D'Angelo
This research explores the perceptions of adolescents and young adults (AYA) living with perinatally acquired HIV (PHIV) as they transition into parenthood. We conducted hour-long, semistructured audio-recorded interviews with a purposive sample of 17 AYA parents with PHIV who were current or former patients at two US pediatric/adolescent infectious diseases clinics. Participants were asked about challenges/rewards of parenting and anticipated future fertility desires/intentions. Analysis of the transcribed interviews was guided by grounded theory...
November 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29039984/financial-barriers-and-lapses-in-treatment-and-care-of-hiv-infected-adults-in-a-southern-state-in-the-united-states
#15
David A Wohl, Rita K Kuwahara, Kamran Javadi, Christine Kirby, David L Rosen, Sonia Napravnik, Claire Farel
Antiretroviral (ARV) adherence has largely been considered from the perspective of an individual's behavior with less attention given to potential structural causes for lapses in treatment, such as the cost of medications and care. HIV medication expense is typically covered by third party payers. However, private insurance premiums and deductibles may rise, or policies terminated such as with a change in employment. Likewise, a patient's eligibility for publicly funded coverage like state AIDS Drug Assistance Programs (ADAP) or Medicaid can also be lost...
November 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28981337/comparing-outcomes-of-hiv-infected-chinese-adults-on-antiretroviral-therapy-by-cd4-count-at-treatment-initiation-a-nationwide-retrospective-observational-cohort-study-2012-2014
#16
Ran Hu, Fujie Zhang, Vania Wang, Zhihui Dou, Colin Shepard, Decai Zhao, Xia Liu, Weiwei Mu, Yasong Wu, Hongxin Zhao, Huiqin Li
The chief concerns for antiretroviral therapy (ART) programs considering removal of CD4(+) cell count thresholds for treatment are the increased incidence of ART-related adverse events. A nationwide observational cohort study was conducted among patients who initiated ART in 2012. We divided the eligible patients into three groups: an early ART group with a baseline CD4(+) cell count of 500 cells/μL or greater, a standard ART group with a baseline CD4(+) cell count between 350 and 499 cells/μL, and a late ART group with a baseline CD4(+) cell count between 200 and 349 cells/μL...
October 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28981336/fostering-a-feeling-of-worth-among-vulnerable-hiv-populations-the-role-of-linkage-to-care-specialists
#17
Michelle R Broaddus, Jill Owczarzak, Casey Schumann, Kimberly A Koester
To address barriers to adequate engagement in medical care among people living with HIV, Wisconsin's AIDS/HIV Program created a new position, the Linkage to Care (LTC) Specialist. Specialists provide intensive, short-term case management and patient navigation services for small caseloads of individuals at high risk of disengaging with medical care. Clients are eligible if they are newly diagnosed with HIV or new to medical care, recently released from incarceration, recently out of care, nonadherent to scheduled medical care visits, or have detectable viral load while in care...
October 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28981335/strengthening-the-hiv-care-continuum-in-the-dominican-republic-application-of-a-triadic-implementation-framework-to-meet-the-unaids-90-90-90-treatment-goal
#18
Alex S Bowman, Mili Mehta, Leonel Lerebours Nadal, Mina Halpern, Stephen W Nicholas, Silvia Amesty
Innovative empirical frameworks to evaluate progress in efforts addressing HIV treatment and prevention barriers in resource-limited areas are sorely needed to achieve the UNAIDS 90-90-90 goal (90% diagnosed, 90% on treatment, and 90% virally suppressed). A triadic implementation framework (TIF) is a comprehensive conceptual tool for (1) monitoring attrition, (2) evaluating operational programs, and (3) measuring the impact of specific implementation goals within the care continuum. TIF will assess the effects of enhanced programs on adherence and virologic suppression within the HIV care continuum at a regional clinic in the Dominican Republic (Clínica de Familia La Romana [CFLR]) and its program serving high-risk, migratory batey (sugarcane cultivation) communities...
October 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28981334/adolescent-and-adult-hiv-providers-definitions-of-hiv-infected-youths-successful-transition-to-adult-care-in-the-united-states
#19
Morgan M Philbin, Amanda E Tanner, Alice Ma, Brittany D Chambers, Samuella Ware, Elizabeth N Kinnard, Sophia A Hussen, Sonia Lee, J Dennis Fortenberry
It is important for both individual- and population-level health that HIV-infected individuals progress through the Care Continuum. However, HIV-infected youth frequently disengage from care during transition from pediatric/adolescent to adult care; only 50% remain in adult care after 1 year. Understanding how providers define and approach a successful healthcare transition can improve the delivery of HIV-related services during critical years of HIV treatment. We conducted 58 staff interviews across 14 Adolescent Trials Network clinics (n = 30) and 20 adult clinics (n = 28)...
October 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28891717/longitudinal-viral-suppression-among-a-cohort-of-adolescents-and-young-adults-with-behaviorally-acquired-human-immunodeficiency-virus
#20
Sarah M Wood, Elizabeth Lowenthal, Susan Lee, Sarah J Ratcliffe, Nadia Dowshen
Youth living with HIV (YLWH) are less likely than older adults to achieve and sustain viral suppression. While treatment guidelines recommend decreased viral load (VL) monitoring in individuals with well-controlled HIV, the appropriateness of this strategy for adolescents is unknown. We conducted a retrospective cohort study to describe longitudinal viral suppression and identify incidence of, and risk factors for, virologic failure among YLWH at a US adolescent HIV clinic from 2002 to 2015. We utilized Cox proportional hazards modeling to compare hazard ratios (HRs) for virologic failure stratified by baseline characteristics...
September 2017: AIDS Patient Care and STDs
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