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https://www.readbyqxmd.com/read/28514282/recent-progress-in-anti-hiv-broadly-neutralizing-antibody-research
#1
Stacey C Tobin
No abstract text is available yet for this article.
May 16, 2017: AIDS
https://www.readbyqxmd.com/read/28514281/acute-hyperinsulinemia-effects-on-systemic-markers-of-immune-activation-in-hiv
#2
Timothy K O'malley, Tricia H Burdo, Jake A Robinson, Kathleen V Fitch, Steven K Grinspoon, Suman Srinivasa
: The well-treated HIV population remains at risk for insulin resistance and chronic immune activation. We tested the effects of acute hyperinsulinemia on inflammation in HIV. Twenty HIV-infected and 10 non-HIV-infected individuals well-matched for BMI underwent oral glucose tolerance testing to stimulate insulin secretion and assess for changes in circulating sCD163, sCD14, and MCP-1. sCD14 decreased significantly after stimulation of hyperinsulinemia and no significant changes in sCD163 or MCP-1 were demonstrated in HIV-infected and non-HIV-infected groups...
May 16, 2017: AIDS
https://www.readbyqxmd.com/read/28514280/ten-year-trends-in-anti-retroviral-therapy-persistence-among-us-medicaid-beneficiaries-2001-2010
#3
Bora Youn, Theresa I Shireman, Yoojin Lee, Omar Galárraga, Aadia I Rana, Amy C Justice, Ira B Wilson
OBJECTIVE: Whether the rate of HIV antiretroviral therapy (ART) persistence has improved over time in the U.S. is unknown. We examined ART persistence trends between 2001 and 2010, using non-HIV medications as a comparator. METHODS: We conducted a retrospective cohort study using Medicaid claims. We defined persistence as the duration of treatment from the first to the last fill date before a 90-day permissible gap, and used Kaplan-Meier curves and Cox proportional hazard models to assess crude and adjusted non-persistence...
May 16, 2017: AIDS
https://www.readbyqxmd.com/read/28514279/impact-of-alemtuzumab-on-hiv-persistence-in-an-hiv-infected-individual-on-antiretroviral-therapy-with-sezary-syndrome
#4
Thomas Aagaard Rasmussen, James McMahon, J Judy Chang, Jori Symons, Michael Roche, Ashanti Dantanarayana, Afam Okoye, Bonnie Hiener, Sarah Palmer, Wen Shi Lee, Stephen Kent, Carrie Van Der Weyden, H Miles Prince, Paul U Cameron, Sharon R Lewin
OBJECTIVE: To study the effects of alemtuzumab on HIV persistence in an HIV-infected individual on antiretroviral therapy (ART) with Sezary syndrome, a rare malignancy of CD4+ T-cells DESIGN:: Case report. METHODS: Blood was collected 30 and 18 months prior to presentation with Sezary syndrome, at the time of presentation and during alemtuzumab. T-cell subsets in malignant (CD7-CD26-TCR-VBeta2+) and non-malignant cells were quantified by flow cytometry. HIV-DNA in total CD4+ T-cells, in sorted malignant and non-malignant CD4+ T-cells was quantified by PCR and clonal expansion of HIV-DNA assessed by full-length next-generation sequencing...
May 16, 2017: AIDS
https://www.readbyqxmd.com/read/28514278/impact-of-screening-and-art-on-anal-cancer-incidence-in-hiv-positive-men-who-have-sex-with-men-mathematical-modeling-study
#5
Nello Blaser, Barbara Bertisch, Roger D Kouyos, Alexandra Calmy, Heiner C Bucher, Matthias Cavassini, Janne Estill, Olivia Keiser, Matthias Egger
BACKGROUND: The incidence of anal cancer is high in HIV-positive men who have sex with men (MSM). We modeled the impact of screening strategies and combination antiretroviral therapy (cART) coverage on anal cancer incidence in Switzerland. METHODS: Individual-based, dynamic simulation model parameterized with Swiss HIV Cohort Study (SHCS) and literature data. We assumed all men to be HPV infected. CD4 cell count trajectories were the main predictors of anal cancer...
May 16, 2017: AIDS
https://www.readbyqxmd.com/read/28514277/a-commitment-contract-to-achieve-virologic-suppression-in-poorly-adherent-patients-with-hiv-aids
#6
Marcella Alsan, John Beshears, Wendy S Armstrong, James J Choi, Brigitte C Madrian, Minh Ly T Nguyen, Carlos Del Rio, David Laibson, Vincent C Marconi
OBJECTIVE: Assess whether a commitment contract informed by behavioral economics leads to persistent virologic suppression among HIV-positive patients with poor antiretroviral therapy (ART) adherence. DESIGN: Single-center pilot randomized clinical trial, plus a non-randomized control group. SETTING: Publicly-funded HIV clinic in Atlanta, Georgia, USA. INTERVENTION: The study involved three arms. (i) Participants in the provider visit incentive arm received $30 after attending each scheduled provider visit...
May 16, 2017: AIDS
https://www.readbyqxmd.com/read/28514276/sexual-network-drivers-of-hiv-and-herpes-simplex-virus-type-2-hsv-2-transmission-a-comparative-mathematical-modeling-analysis
#7
Ryosuke Omori, Laith J Abu-Raddad
OBJECTIVES: HIV and herpes simplex virus type 2 (HSV-2) infections are sexually transmitted and propagate in sexual networks. Using mathematical modeling, we aimed to quantify effects of key network statistics on infection transmission, and extent to which HSV-2 prevalence can be a proxy of HIV prevalence. DESIGN/METHODS: An individual-based simulation model was constructed to describe sex partnering and infection transmission, and was parameterized with representative natural history, transmission, and sexual behavior data...
May 16, 2017: AIDS
https://www.readbyqxmd.com/read/28481774/a-common-anti-cmv-drug-ganciclovir-inhibits-hiv-1-replication-in-human-tissues-ex-vivo
#8
Christophe Vanpouille, Jean A Bernatchez, Andrea Lisco, Anush Arakelyan, Elisa Saba, Matthias Götte, Leonid Margolis
: Cytomegalovirus (CMV) is a common HIV-1 copathogen. Since CMV infection is an important contributor to immune activation, the driving force of HIV disease, an anti-CMV strategy might be beneficial to HIV-infected patients. Shin et al. reported that anti-CMV therapy with valganciclovir in coinfected individuals results in a decrease of HIV viral load that is not accompanied by a decrease of immune activation. This suggests an alternative mechanism for HIV inhibition other than suppression of CMV-mediated inflammation...
May 5, 2017: AIDS
https://www.readbyqxmd.com/read/28481773/who-provides-additional-guidance-on-hiv-self-testing-and-partner-notification
#9
Stacey C Tobin
No abstract text is available yet for this article.
May 5, 2017: AIDS
https://www.readbyqxmd.com/read/28481772/hiv-drug-resistance-in-africa-an-emerging-problem-that-deserves-urgent-attention
#10
Milagros Moreno, Estrella Caballero, Raquel M Mateus, Filomena Samba, Eva Gil, Vicenç Falcó
No abstract text is available yet for this article.
May 5, 2017: AIDS
https://www.readbyqxmd.com/read/28481771/cd4-cd8-ratio-restoration-in-long-term-treated-hiv-1-infected-individuals-incidence-and-determinants
#11
Fabienne Caby
OBJECTIVES: A persistently low CD4/CD8 ratio despite virological control reflects a higher risk of morbidity in HIV-infected individuals. The objective of the study was to assess the probability and determinants of ratio restoration (≥1) during long-term cART. DESIGN: Study cohort based on the French Hospital Database on HIV (FHDH-ANRS CO4). METHODS: Antiretroviral naïve HIV-1 infected individuals were included if they achieved virological control (plasma HIV-RNA≤500 copies/ml) within 9 months following cART, started between 2000 and 2010...
May 5, 2017: AIDS
https://www.readbyqxmd.com/read/28481770/elective-cesarean-section-for-women-living-with-hiv-a-systematic-review-of-risks-and-benefits
#12
Caitlin E Kennedy, Ping Teresa Yeh, Shristi Pandey, Ana Pilar Betran, Manjulaa Narasimhan
OBJECTIVE AND DESIGN: To inform World Health Organization guidelines, we conducted a systematic review and meta-analysis to assess maternal and perinatal outcomes comparing cesarean section before labor and rupture of membranes (elective c-section/ECS) with other modes of delivery for women living with HIV. METHODS: We searched PUBMED, CINAHL, Embase, CENTRAL, and previous reviews to identify published trials and observational studies through October 2015. Results were synthesized using random-effects meta-analysis, stratifying for combination antiretroviral therapy (cART), CD4/viral load (VL), delivery at term, and low-/middle-income countries (LMICs)...
May 5, 2017: AIDS
https://www.readbyqxmd.com/read/28471766/what-works-reaching-universal-hiv-testing-lessons-from-hptn-071-popart-trial-in-zambia
#13
Kwame Shanaube, Ab Schaap, Sian Floyd, Mwelwa Phiri, Sam Griffith, Joseph Chaila, Peter Bock, Richard Hayes, Sarah Fidler, Helen Ayles
OBJECTIVE: To determine the uptake of home-based HIV counselling and testing (HCT) in four HPTN071 (PopART) trial communities (implementing a 'full' combination HIV prevention package that includes universal HIV testing and treatment) in Zambia. We also explore factors associated with uptake of HCT in these communities. DESIGN: HPTN071 (PopART) is a 3-arm community-randomized trial in 12 communities in Zambia and 9 communities in South Africa evaluating the impact of a combination HIV revention package, including universal HIV testing and treatment, on HIV incidence...
May 3, 2017: AIDS
https://www.readbyqxmd.com/read/28471765/impact-of-aging-on-neurocognitive-performance-in-previously-antiretroviral-na%C3%A3-ve-hiv-individuals-on-their-first-suppressive-regimen
#14
Hamza Coban, Kevin Robertson, Marlene Smurzynski, Supriya Krishnan, Kunling Wu, Ronald J Bosch, Ann C Collier, Ronald J Ellis
BACKGROUND: Despite treatment with virologically suppressive antiretroviral therapy (ART), neurocognitive impairment may persist or develop de novo in aging HIV-infected individuals. We evaluated advancing age as a predictor of neurocognitive impairment in a large cohort of previously ART-naïve individuals on long-term ART DESIGN:: The AIDS Clinical Trials Group (ACTG) Longitudinal Linked Randomized Trials (ALLRT) was a prospective cohort study of HIV-infected individuals originally enrolled in randomized ART trials...
May 3, 2017: AIDS
https://www.readbyqxmd.com/read/28463886/renal-and-bone-effects-of-tenofovir-containing-regimens-compared-in-a-large-real-world-patient-population
#15
Stacey C Tobin
No abstract text is available yet for this article.
May 1, 2017: AIDS
https://www.readbyqxmd.com/read/28463885/examination-of-hiv-infection-through-heterosexual-contact-with-partners-who-are-known-to-be-hiv-infected-in-the-united-states-2010-2015
#16
Nicole Crepaz, Bill Dong, Mi Chen, Irene Hall
: Using data from the National HIV Surveillance System, we examined HIV infections diagnosed between 2010 and 2015 attributed to heterosexual contact with partners previously known to be HIV infected. More than 4 in 10 HIV infections among heterosexual males and 5 in 10 HIV infections among heterosexual females were attributed to this group. Findings may inform the prioritization of prevention and care efforts and resource allocation modeling for reducing new HIV infection among discordant partnerships.
May 1, 2017: AIDS
https://www.readbyqxmd.com/read/28463884/beyond-antiretroviral-therapy-early-interventions-to-control-hiv-1-infection
#17
Jesper Damsgaard Gunst, Martin Tolstrup, Ole Schmeltz Søgaard
No abstract text is available yet for this article.
May 1, 2017: AIDS
https://www.readbyqxmd.com/read/28463883/htlv-1-infection-and-disease-in-spain
#18
Carmen de Mendoza, Estrella Caballero, Antonio Aguilera, Silvia Requena, Raúl Ortiz de Lejarazu, María Pirón, Rocío González, Ana Jiménez, Lourdes Roc, Ana Treviño, Rafael Benito, Miriam Fernández-Alonso, Aitziber Aguinaga, Carmen Rodríguez, Juan García-Costa, Lidia Blanco, José M Ramos, Enrique Calderón, José M Eirós, Silvia Sauleda, Pablo Barreiro, Vicente Soriano
: Human T-lymphotropic virus type 1 (HTLV-1) infection is a neglected disease despite roughly 15 million people are chronically infected worldwide. Lifelong less than 10% of carriers develop life-threatening diseases, mostly a subacute myelopathy known as tropical spastic paraparesis (TSP) and a lymphoproliferative disorder named adult T-cell leukemia (ATL). HTLV-1 is efficiently transmitted perinatally (breastfeeding), sexually (more from male to female) and parenterally (transfusions, injection drug use and transplants)...
May 1, 2017: AIDS
https://www.readbyqxmd.com/read/28463882/impact-of-intensified-antiretroviral-therapy-during-early-hiv-infection-on-gut-immunology-and-inflammatory-blood-biomarkers-a-randomized-controlled-trial
#19
Connie J Kim, Rodney Rousseau, Sanja Huibner, Colin Kovacs, Erika Benko, Kamnoosh Shahabi, Gabor Kandel, Mario Ostrowski, Rupert Kaul
OBJECTIVE: Standard antiretroviral therapy (ART) is slow to reverse gut mucosal immune defects that cause persistent inflammation and immune activation. We examined whether intensifying early-administered ART through the addition of maraviroc and raltegravir would accelerate their resolution. DESIGN: ART-naïve men with early HIV infection were randomized in a double-blind manner to receive ART (emtricitabine/tenofovir disoproxil fumarate + lopinavir/ritonavir), together with either combined raltegravir/maraviroc or placebo, for 48 weeks...
May 1, 2017: AIDS
https://www.readbyqxmd.com/read/28463881/emphysema-and-soluble-cd14-are-associated-with-pulmonary-nodules-in-hiv-infected-patients-implications-for-lung-cancer-screening
#20
Matthew Triplette, Keith M Sigel, Alison Morris, Shahida Shahrir, Juan P Wisnivesky, Chung Y Kong, Phillip T Diaz, Alycia Petraglia, Kristina Crothers
OBJECTIVE: Lung cancer screening may benefit HIV-infected (HIV+) smokers due to an elevated risk of lung cancer, but may have unique harms because of HIV-specific risk factors for false-positive screens. This study seeks to understand whether inflammatory biomarkers and markers of chronic lung disease are associated with non-calcified nodules ≥4 mm in HIV-infected (HIV+) compared to uninfected patients. DESIGN: This is a cohort study of the Examinations of HIV-Associated Lung Emphysema (EXHALE), including 158 HIV+ and 133 HIV-uninfected participants...
May 1, 2017: AIDS
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