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https://www.readbyqxmd.com/read/28723712/the-role-of-oncogenic-hpv-determination-for-diagnosis-of-high-grade-anal-intraepithelial-neoplasia-in-hiv-infected-msm
#1
Joaquin Burgos, J Hernández-Losa, S Landolfi, A Guelar, Mªc Dinares, J Villar, J Navarro, E Ribera, V Falcó, A Curran
OBJECTIVE: To assess the oncogenic human papillomavirus (HPV) determination and the co-testing HPV and anal cytology value to detect high-grade anal intraepithelial neoplasia (HGAIN) in a cohort of HIV-MSM. DESIGN AND METHODS: Prospective study of HIV-infected MSM who underwent screening for anal dysplasia. Screening program includes anal cytology, HPV testing, and high-resolution anoscopy (HRA) at each visit. Histological samples were obtained if suspicious lesions were revealed by HRA...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28723711/epidemiology-of-autoimmune-and-inflammatory-diseases-in-a-french-nationwide-hiv-cohort
#2
D Lebrun, M Hentzien, L Cuzin, D Rey, V Joly, L Cotte, C Allavena, P Dellamonica, A Servettaz, F Bani-Sadr
HIV infection and inflammatory and autoimmune diseases (IAD) are both related to immune dysfunction. Epidemiological data on IAD in patients living with HIV (PLHIV) are scarce. The aim of this study was thus to estimate the prevalence of 26 IAD among PLHIV followed in a large French multicenter cohort in the cART era (from January 2000 to July 2013), and to describe their occurrence according to cART onset, the immuno-virological status of patients and HCV and/or HBV co-infection.During the study period, 33 403 PLHIV were included in the Dat'AIDS cohort; 1381 patients with an IAD were identified...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28723710/controlled-attenuation-parameter-and-mr-spectroscopy-measured-liver-steatosis-are-discordant-in-hiv-infected-adults-with-high-body-mass
#3
Jennifer C Price, Jennifer L Dodge, Yifei Ma, Rebecca Scherzer, Natalie Korn, Kyle Tillinghast, Marion G Peters, Susan Noworolski, Phyllis C Tien
OBJECTIVE: Hepatic steatosis (HS) is common in HIV-infected individuals. Magnetic resonance spectroscopy (MRS) is the preferred non-invasive method for HS measurement but is expensive. Controlled attenuation parameter (CAP) also assesses HS and is conveniently performed concomitantly with transient elastography. We aimed to assess the accuracy of CAP in the setting of HIV infection. DESIGN: Cross-sectional study. METHODS: CAP and MRS were performed in 82 subjects (39 HIV-monoinfected;7 HCV-monoinfected;21 HIV/HCV-coinfected; 15 with neither infection)...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28723709/delivering-prep-to-pregnant-and-breastfeeding-women-in-sub-saharan-africa-the-implementation-science-frontier
#4
Dvora L Joseph Davey, Linda-Gail Bekker, Pamina Gorbach, Thomas Coates, Landon Myer
: HIV acquisition during pregnancy and postpartum periods remains high despite increased access to and initiation of antiretroviral therapy in sub-Saharan Africa. Moreover, maternal seroconversion during pregnancy and breastfeeding remains a source of significant paediatric HIV infection in the region. In order to curb vertical HIV transmission, HIV acquisition during pregnancy and lactation must significantly decline. Biological and behavioural factors contribute to high HIV incidence, including hormonal changes that alter genital mucosal surfaces, and frequent condomless sex with HIV-infected partners or partners of unknown serostatus...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28723708/subclinical-herpesvirus-shedding-among-hiv-1-infected-men-on-antiretroviral-therapy
#5
Arcadio Agudelo-Hernandez, Yue Chen, Arlene Bullotta, William G Buchanan, Cynthia R Klamar-Blain, Luann Borowski, Sharon A Riddler, Charles R Rinaldo, Bernard Jc Macatangay
DESIGN: We evaluated the subclinical shedding of 6 different herpesviruses in antiretroviral drug-treated HIV(+) men who have sex with men (MSM), and determined how this is associated with markers of inflammation and immune activation. METHODS: We obtained blood, semen, throat washing, urine, and stool from 15 antiretroviral-treated HIV-1-infected MSM with CD4 T cell reconstitution, and 12 age-matched HIV(-) MSM from the Multicenter AIDS Cohort Study at 4 timepoints over 24 weeks to measure DNA levels of cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus 1 and 2, human herpesvirus 6 (HHV6), and HHV8...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28723707/towards-standardised-definitions-for-monitoring-the-continuum-of-hiv-care-in-europe
#6
Annabelle J Gourlay, Anastasia M Pharris, Teymur Noori, Virginie Supervie, Magdalena Rosinska, Ard van Sighem, Giota Touloumi, Kholoud Porter
No abstract text is available yet for this article.
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28723706/oral-shedding-of-herpesviruses-in-hiv-patients-with-varying-degrees-of-immune-status
#7
Dirk P Dittmer, Kristen Tamburro, Huichao Chen, Anthony Lee, Marcia K Sanders, Tischan A Wade, Sonia Napravnik, Jennifer Webster-Cyriaque, Mahmoud Ghannoum, Caroline H Shiboski, Judith A Aberg
OBJECTIVE: Herpesvirus shedding in the oral cavity was analyzed to determine if presence in the oral compartment correlates with systemic changes in HIV-associated immune deficiency as measured by CD4+ counts, plasma HIV viral load (VL) and presence of AIDS-defining events. DESIGN: A5254 is a multicenter, cross-sectional, single-visit study to evaluate oral complications of HIV/AIDS and determine the association between clinical appearance, herpesvirus shedding and immune status as ascertained by CD4 count and HIV viral load...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28692547/seroprevalence-of-hepatitis-e-virus-in-hiv-infected-patients-in-china
#8
Hang Zeng, Lin Wang, Peng Liu, Lingjie Liao, Ling Wang, Yiming Shao
: The seroprevalence of hepatitis E virus (HEV) in HIV-infected patients in China has never been reported. Thus, anti-HEV in HIV-infected patients recruited in five provinces in China was tested. The seroprevalence of HEV was 39.7%, which was higher than that in the general population (23.5%). HEV infection might be a frequent cause of hepatitis in HIV-infected patients.
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692546/hhv8-and-kaposi-s-sarcoma-should-we-really-give-up-protease-inhibitors-in-all-hiv-infected-patients
#9
Patrick Philibert, Laurent Chiche, Sylvie Caillères, Julie Allemand, Stanislas Rebaudet, Marion Delord, Chloé Stavris, Frédérique Retornaz, Hacène Khiri, Philippe Halfon
We describe the first case of a patient presenting Kaposi's Sarcoma with HHV8 viremia after switching from a protease inhibitor (PI) to an integrase inhibitor-based combination antiretroviral therapy, followed by a rapid remission when resuming PI. We suggest that the recent recommendations to switch all HIV patients to PI-free regimens should be carefully reevaluated especially in men who have sex with men HIV patients which are at higher risks of HHV8 infections and associated malignancies.
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692545/selection-of-women-at-risk-for-cervical-cancer-in-an-hiv-infected-south-african-population
#10
Marjolein Van Zummeren, Wieke W Kremer, Matthys C Van Aardt, Erika Breytenbach, Karin L Richter, Lawrence Rozendaal, Birgit I Witte, Lise M A de Strooper, Albertus T Hesselink, Daniëlle A M Heideman, Peter J F Snijders, Renske D M Steenbergen, Greta Dreyer, Chris J L M Meijer
OBJECTIVE: Cervical cancer is the leading cause of cancer-related death in women in South Africa. This study evaluates DNA methylation levels in cervical (pre)cancer and aims to assess the value of high-risk human papillomavirus (hrHPV) testing and methylation analysis, alone or in combination, on physician-taken cervical scrapes to detect cervical cancer, and cervical intraepithelial neoplasia grade 3 (CIN3) in an HIV-infected South African population. DESIGN: Prospective observational multi-centre cohort study...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692544/the-effect-of-school-attendance-and-school-dropout-on-incident-hiv-and-hsv-2-among-young-women-in-rural-south-africa-enrolled-in-hptn-068
#11
Marie C D Stoner, Audrey Pettifor, Jessie K Edwards, Allison E Aiello, Carolyn T Halpern, Aimée Julien, Amanda Selin, Rhian Twine, James P Hughes, Jing Wang, Yaw Agyei, F Xavier Gomez-Olive, Ryan G Wagner, Catherine Macphail, Kathleen Kahn
OBJECTIVE: To estimate the association between school attendance, school dropout, and risk of incident HIV and HSV-2 infection among young women. DESIGN: We used longitudinal data from a randomized controlled trial in rural Mpumalanga province, South Africa, to assess the association between school days attended, school dropout and incident HIV and HSV-2 in young women aged 13-23 years. METHODS: We examined inverse probability of exposure weighted survival curves and used them to calculate 1...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692543/impact-and-economic-evaluation-of-a-novel-hiv-service-delivery-model-in-rural-malawi
#12
Ryan K McBain, Elizabeth Petersen, Nora Tophof, Elizabeth Dunbar, Noel Kalanga, Lawrence Nazimera, Andrew Mganga, Luckson Dullie, Joia Mukherjee, Emily B Wroe
OBJECTIVE: We performed an impact and cost-effectiveness analysis of a novel HIV service delivery model in a high prevalence, remote district of Malawi with a population of 143,800 people. DESIGN: A population-based retrospective analysis of one-year survival rates among newly-enrolled HIV+ patients at 682 health facilities throughout Malawi, comparing facilities implementing the service delivery model (n = 13) and those implementing care-as-usual (n = 669)...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692542/the-effect-of-oral-pre-exposure-prophylaxis-on-the-progression-of-hiv-1-seroconversion
#13
Deborah Donnell, Eric Ramos, Connie Celum, Jared Baeten, Joan Dragavon, Jordan Tappero, Jairam R Lingappa, Allan Ronald, Kenneth Fife, Robert W Coombs
OBJECTIVE: To investigate whether oral pre-exposure prophylaxis (PrEP) alters timing and patterns of seroconversion when PrEP use continues after HIV-1 infection. DESIGN: Retrospective testing of the timing of Fiebig stage HIV-1 seroconversion in the Partners PrEP Study, a randomized placebo-controlled clinical trial of PrEP conducted in Kenya and Uganda. METHODS: Specimens from 138 seroconverters were collected every 3 months and when HIV-1 infection was suspected based on monthly rapid HIV-1 tests...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692541/the-value-of-point-of-care-cd4-and-laboratory-viral-load-in-tailoring-art-monitoring-strategies-to-resource-limitations
#14
Emily P Hyle, Ilesh V Jani, Katherine L Rosettie, Robin Wood, Benjamin Osher, Stephen Resch, Pamela P Pei, Paolo Maggiore, Kenneth A Freedberg, Trevor Peter, Robert A Parker, Rochelle P Walensky
OBJECTIVE: To examine the clinical and economic value of point-of-care CD4 (POC-CD4) or viral load (VL) monitoring compared to current practices in Mozambique, a country representative of the diverse resource limitations encountered by HIV treatment programs in sub-Saharan Africa. DESIGN/METHODS: We use the CEPAC-I model to examine the clinical impact, cost (2014 US$), and incremental cost-effectiveness ratio (ICER, $/year of life saved [YLS]) of ART monitoring strategies in Mozambique...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692540/unique-microrna-expression-in-the-colonic-mucosa-during-chronic-hiv-1-infection
#15
Jennifer A Fulcher, Georgios Koukos, Marina Koutsioumpa, Julie Elliott, Alexandra Drakaki, Dimitrios Iliopoulos, Peter A Anton
OBJECTIVE: Chronic HIV-1 infection leads to widespread inflammation and immune dysregulation. The gastrointestinal mucosa, a primary site for HIV-1 replication, is thought to play a significant role in this response. MicroRNAs (miRs) are small non-coding RNAs that regulate gene expression, including immune activation and inflammation. Here we investigate miR expression and function in the colonic mucosa during HIV-1 infection. DESIGN AND METHODS: Using miR profiling, we examined miR expression in the colonic mucosa of HIV-infected subjects...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692539/hiv-hepatitis-b-virus-co-infection-epidemiology-pathogenesis-and-treatment
#16
Kasha P Singh, Megan Crane, Jennifer Audsley, Sharon R Lewin
: HIV infection has a significant impact on the natural history of chronic hepatitis B virus (HBV) infection, with increased levels of HBV DNA, accelerated progression of liver disease, and increased liver-associated mortality compared with HBV monoinfection. Widespread uptake and early initiation of HBV-active antiretroviral therapy has substantially improved the natural history of HIV-HBV coinfection but the prevalence of liver disease remains elevated in this population. In this paper, we review recent studies examining the natural history and pathogenesis of liver disease and seroconversion in HIV-HBV coinfection in the era of HBV-active antiretroviral therapy and the effects of HIV directly on liver disease...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692538/metabolic-syndrome-and-obesity-are-the-cornerstones-of-liver-fibrosis-in-hiv-monoinfected-patients-results-of-the-metafib-study
#17
Maud Lemoine, Karine Lacombe, Jean Philippe Bastard, Manuela Sébire, Laurent Fonquernie, Nadia Valin, Soraya Fellahi, Jacqueline Capeau, Pierre-Marie Girard, Jean-Luc Meynard
BACKGROUND: Metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD) have become a common finding in HIV-infected patients. However, the severity, risk factors and pathogenesis of liver fibrosis in this population have been poorly documented. OBJECTIVES: to assess the impact of MetS on liver fibrosis and analyze the association between MetS, liver fibrosis and markers of adipose tissue and macrophage activation. METHODS: In a matched cohort of HIV-1-monoinfected patients with and without MetS, after exclusion of other causes of liver disease, we assessed liver stiffness measurement (LSM) and measured levels of serum adipokines, HOMA index and soluble CD163 and CD14 as markers of fat, insulin resistance and macrophage/monocyte activation, respectively...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692537/early-initiation-of-antiretroviral-treatment-post-siv-infection-does-not-resolve-lymphoid-tissue-activation
#18
Jung Joo Hong, Eduardo L V Silveira, Praveen K Amancha, Siddappa N Byrareddy, Sanjeev Gumber, Kyu-Tae Chang, Aftab A Ansari, Francois Villinger
OBJECTIVE: Germinal center (GC) resident follicular helper T (TFH) cells in lymphoid follicles are a potential sanctuary for HIV/SIV replication. But the dynamics of GCs upon early initiation of antiretroviral therapy (ART) and their potential role in the formation of viral sanctuaries post SIV infection are not fully understood. DESIGN: Sequential lymph node biopsies (n = 10) were collected from SIVmac239-infected rhesus macaques before infection, at 5 weeks post infection/pre ART, 6 and 12 weeks following ART initiation...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692536/asymptomatic-anorectal-chlamydia-trachomatis-and-neisseria-gonorrhoeae-infections-are-associated-with-systemic-cd8-t-cell-activation
#19
Vinicius A Vieira, Vivian I Avelino-Silva, Natalia B Cerqueira, Dayane A Costa, Priscilla R Costa, Ricardo P Vasconcelos, Valdez R Madruga, Ronaldo Ismério Moreira, Brenda Hoagland, Valdiléa G Veloso, Beatriz Grinsztejn, Esper G Kallás
BACKGROUND: Oral pre-exposure prophylaxis (PrEP) has been established as a pivotal strategy in HIV prevention. However, bacterial sexually transmitted infections (STIs), such as Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), are also highly prevalent. Although the presence of STI-related mucosal lesions is a known risk factor for HIV acquisition, the potential increase in risk associated with asymptomatic STIs is not completely understood. Recent data demonstrated higher T cell activation is a risk factor for sexually acquired HIV-1 infection...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692535/effect-of-cmv-and-ebv-replication-on-intestinal-mucosal-gene-expression-and-microbiome-composition-of-hiv-infected-and-uninfected-individuals
#20
Sara Gianella, Antoine Chaillon, Ece A Mutlu, Phillip A Engen, Robin M Voigt, Ali Keshavarzian, John Losurdo, Prachi Chakradeo, Steven M Lada, Masato Nakazawa, Alan L Landay
BACKGROUND: HIV-infection is associated with dramatic changes in the intestinal mucosa. The impact of other viral pathogens is unclear. METHODS: Eighty biopsies from left and right colon (n=63) and terminal ileum (n = 17) were collected from 19 HIV-infected and 22 HIV-uninfected subjects. Levels of cytomegalovirus (CMV) and Epstein Barr Virus (EBV) DNA were measured by droplet-digital (dd)PCR. Mucosal gene expression was measured via multiplex-assay. Microbiome analysis was performed using bacterial 16S-rDNA-pyrosequencing...
July 7, 2017: AIDS
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