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https://www.readbyqxmd.com/read/29280762/brentuximab-vedotin-with-avd-shows-safety-in-the-absence-of-strong-cyp3a4-inhibitors-in-newly-diagnosed-hiv-associated-hodgkin-lymphoma
#1
Paul G Rubinstein, Page C Moore, Michelle A Rudek, David H Henry, Juan C Ramos, Lee Ratner, Erin Reid, Elad Sharon, Ariela Noy
OBJECTIVE: Brentuximab vedotin (BV) is an FDA approved anti-CD30 antibody drug conjugate potently active in Hodgkin lymphoma (HL). Trials of BV with doxorubicin, vinblastine, and dacarbazine (AVD-BV) excluded patients with HIV. We studied the safety of (AVD-BV) in newly diagnosed HIV-associated classical Hodgkin lymphoma (HIV-cHL). DESIGN AND METHODS: Patients diagnosed with Stage II-IV HIV-cHL received AVD-BV on days 1 and 15 every 28 days for 6 cycles. Anti-HIV medications with strong CYP3A4 inhibition were excluded...
December 26, 2017: AIDS
https://www.readbyqxmd.com/read/29280761/a-baseline-metabolomic-signature-is-associated-with-immunological-cd4-t-cell-recovery-after-36-months-of-art-in-hiv-infected-patients
#2
Esther Rodríguez-Gallego, Josep Gómez, Yolanda María Pacheco, Joaquim Peraire, Consuelo Viladés, Raúl Beltrán-Debón, Roger Mallol, Miguel López-Dupla, Sergi Veloso, Verónica Alba, Julià Blanco, Nicolau Cañellas, Anna Rull, Manuel Leal, Xavier Correig, Pere Domingo, Francesc Vidal
OBJECTIVES: Poor immunological recovery in treated HIV-infected patients is associated with greater morbidity and mortality. To date, predictive biomarkers of this incomplete immune reconstitution have not been established. We aimed to identify a baseline metabolomic signature associated with a poor immunological recovery after ART in order to envisage the underlying mechanistic pathways that influence the treatment response. DESIGN: This was a multi-centre, prospective cohort study in ART-naïve and a pre-ART low nadir (<200 cells/μl) HIV-infected patients (n = 64)...
December 26, 2017: AIDS
https://www.readbyqxmd.com/read/29280760/the-hiv-1-tat-protein-affects-human-cd4-t-cell-programming-and-activation-and-favors-the-differentiation-of-na%C3%A3-ve-cd4-t-cells
#3
Francesco Nicoli, Eleonora Gallerani, Fabio Sforza, Valentina Finessi, Mkunde Chachage, Christof Geldmacher, Aurelio Cafaro, Barbara Ensoli, Antonella Caputo, Riccardo Gavioli
OBJECTIVE: HIV infection is characterized by several immune dysfunctions, such as chronic activation of the immune system, premature ageing and loss of CD4 T cell, in particular within the naïve compartment. The Tat protein of HIV is released extracellularly and enters neighboring cells affecting their functionality, for instance impacting on CD8 T cell programs and activity. As the presence and/or induction of anti-Tat immune responses is associated with reduced T cell dysfunctions and CD4 T cell loss, we investigated whether Tat impacts human resting or activated CD4 T cells...
December 26, 2017: AIDS
https://www.readbyqxmd.com/read/29280759/phylogenetic-analysis-as-a-forensic-tool-in-hiv-transmission-investigations-a-literature-review
#4
Ana B Abecasis, Marta Pingarilho, Anne-Mieke Vandamme
: Because HIV is a fast-evolving virus, HIV genomic sequences of several individuals can be used to investigate whether they belong to a transmission network. Since the infamous 'Florida dentist case' in the beginning of the 90 s, phylogenetic analyses has been recurrently used in court settings as a forensic tool in HIV transmission investigations, e.g. cases where one or more complainants allege that a defendant has unlawfully infected them with HIV. Such cases can arise both in the context of HIV-specific criminal laws - in countries where transmission of HIV infection is specifically criminalized - or in the context of general laws, for example, by applying physical or sexual assault laws to HIV-related cases...
December 26, 2017: AIDS
https://www.readbyqxmd.com/read/29280758/changes-in-insulin-sensitivity-over-time-and-associated-factors-in-hiv-infected-adolescents
#5
Mitchell E Geffner, Kunjal Patel, Denise L Jacobson, Julia Wu, Tracie L Miller, Rohan Hazra, Mariana Gerschenson, Tanvi Sharma, Margarita Silio, Jennifer Jao, Jody K Takemoto, Russell B Van Dyke, Linda A Dimeglio
OBJECTIVE: To compare prevalence of IR between perinatally HIV-infected (PHIV+) and perinatally HIV-exposed, but uninfected adolescents (PHEU), determine incidence of and contributory factors to new and resolved cases of IR in PHIV+, and evaluate glucose metabolism. DESIGN: Cross-sectional design for comparison of prevalence among PHIV+ and PHEU. Longitudinal design for incidence and resolution of IR among PHIV+ at risk for these outcomes. METHODS: The source population was adolescents from pediatric HIV clinics in the US and Puerto Rico participating in PHACS AMP, an ongoing prospective cohort study designed to evaluate impact of HIV infection and its treatment on multiple domains in preadolescents and adolescents...
December 26, 2017: AIDS
https://www.readbyqxmd.com/read/29280757/kir3dl1-alleles-and-their-epistatic-interactions-with-hla-class-i-influence-resistance-and-susceptibility-to-hiv-1-acquisition-in-the-pumwani-sex-worker-cohort
#6
Ma Luo, Chris Czarnecki, Michelle Nebroski, Joshua Kimani, Nicole Bernard, Francis A Plummer
OBJECTIVE: To determine the associations of KIR3DL1/S1(3DL1/S1) and its epistatic interactions with HLA class I(HLA-I) alleles with resistance and susceptibility to HIV-1. DESIGN: Despite repeated exposure to HIV-1 a subset of women enrolled in the Pumwani sex worker cohort remain HIV uninfected. Previous studies have shown that specific HLA class I and II alleles were associated with this natural immunity. In this study we investigated the association of 3DL1/S1 and its epistatic interactions with HLA-I, with resistance or susceptibility to HIV-1 acquisition...
December 26, 2017: AIDS
https://www.readbyqxmd.com/read/29239898/patient-and-program-level-monitoring-of-differentiated-service-delivery-for-hiv-a-pragmatic-and-parsimonious-approach-is-needed
#7
William J Reidy, Miriam Rabkin, Maureen Syowai, Andrea Schaaf, Wafaa M El-Sadr
No abstract text is available yet for this article.
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239897/ex-vivo-expression-of-chemokine-receptors-on-cells-surrounding-cutaneous-nerves-in-patients-with-hiv-associated-sensory-neuropathy
#8
Jenjira Mountford, Fitri Octaviana, Riwanti Estiasari, Denise Dewanto Setiawan, Ibnu Ariyanto, Silvia Lee, Jessica Gaff, Constance Chew, Connie Jackaman, Peter Kamerman, Catherine Cherry, Patricia Price
OBJECTIVE: HIV-associated sensory neuropathy (HIV-SN) remains common in HIV+ individuals receiving anti-retroviral therapy (ART), even though neurotoxic anti-retroviral drugs (e.g. stavudine) have been phased out of use. Accumulating evidence indicates that the neuropathy is immune-mediated. We hypothesise that chemokines produced locally in the skin promote migration of macrophages and T-cells into the tissue, damaging cutaneous nerves causing HIV-SN. DESIGN: We assessed chemokine receptor expression on infiltrating CD14 and CD3 cells around cutaneous nerves in standardised skin biopsies from HIV-SN+ patients (n = 5), HIV-SN- patients (n = 9) and healthy controls (n = 4)...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239896/ex-vivo-antiretroviral-potency-of-newer-integrase-strand-transfer-inhibitors-cabotegravir-and-bictegravir-in-hiv-1-non-b-subtypes
#9
Ujjwal Neogi, Kamlendra Singh, Shambhu G Aralaguppe, Leonard C Rogers, Duncan T Njenda, Stefan G Sarafianos, Bo Hejdeman, Anders Sönnerborg
OBJECTIVE: To determine the antiretroviral activity of the integrase strand transfer inhibitors (INSTIs), raltegravir, elvitegravir, dolutegravir, cabotegravir and bictegravir, against different subtypes as well as primary and acquired drug resistance mutations (DRM) in a patient-cohort infected with diverse subtypes. DESIGN: Biochemical and virological drug sensitivity analysis using patient derived HIV-1 genes and cross-sectional/longitudinal clinical study. METHODS: Assays for inhibition of 3'-end processing (IC50-3P), strand transfer (IC50-ST) and drug sensitivity (DSA) for five INSTIs were done using patient-derived integrase or gag-pol genes from subtypes A1, B, C, 01_AE and 02_AG...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239895/development-of-broad-neutralization-activity-in-shiv-infected-rhesus-macaques-after-long-term-infection
#10
Nan Gao, Wei Wang, Chu Wang, Tiejun Gu, Rui Guo, Bin Yu, Wei Kong, Chuan Qin, Elena E Giorgi, Zhiwei Chen, Samantha Townsley, Shiu-Lok Hu, Xianghui Yu, Feng Gao
OBJECTIVE: Non-human primates (NHPs) are the only animal model that can be used to evaluate protection efficacy of HIV-1 Env vaccines. However, whether broadly neutralizing antibodies (bnAbs) can be elicited in NHPs infected with simian/human immunodeficiency virus (SHIV) has not been fully understood. The objective of this study is to investigate whether broad neutralization activities were developed in SHIV-infected macaques after long-term infection as in humans. DESIGN: Neutralization breadth and specificities in plasmas from SHIV-infected macaques could be determined by analyzing a panel of tier 2 viruses and their mutants...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239894/temporal-variation-in-hiv-specific-igg-subclass-abs-during-acute-infection-differentiates-spontaneous-controllers-from-chronic-progressors
#11
Saheli Sadanand, Jishnu Das, Amy W Chung, Matthew K Schoen, Sophie Lane, Todd J Suscovich, Hendrik Streeck, Davey Smith, Susan Little, Douglas A Lauffenburger, Douglas Richman, Galit Alter
OBJECTIVE: Given the emerging appreciation for the role of antibody-dependent effector functions and IgG subclass distribution among spontaneous controllers of HIV, we sought to determine whether antibody-associated features diverged in early HIV infection between subjects who ultimately became controllers versus those who became progressors. METHODS: IgG was purified from plasma from nine acutely infected subjects who subsequently controlled HIV spontaneously (controllers) and ten acutely infected individuals who did not control viremia (progressors)...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239893/switch-from-tenofovir-disoproxil-fumarate-combination-to-dolutegravir-plus-rilpivirine-improves-parameters-of-bone-health
#12
Grace A Mccomsey, Sergio Lupo, David Parks, Mónica Coronado Poggio, Joseph De Wet, Lesley P Kahl, Kostas Angelis, Brian Wynne, Kati Vandermeulen, Martin Gartland, Michael Cupo, Michael Aboud
OBJECTIVE: Bone mineral density (BMD) loss, a risk factor for osteoporosis, has been attributed to HIV infection and antiretroviral therapy (ART), including regimens containing tenofovir disoproxil fumarate. DESIGN: Study 202094 is an open-label, parallel-group, sub-study of the phase III SWORD-1 and SWORD-2 studies (ClincialTrials.gov identifier, NCT02478632). METHODS: HIV-1-infected adults with HIV-1 RNA < 50 copies per mL who received ART containing tenofovir disoproxil fumarate for ≥6 months were randomized to receive dolutegravir+rilpivirine or continue current ART regimen...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239892/addressing-hiv-on-the-french-guyanese-brazilian-border-no-choice-but-collaboration
#13
Anna S Boser, Bastien Bidaud, Silvia Maues, Noé Guiraud, Anapaula M Mendes, François Lacapere, Sophie Rhodes, Florence Huber, Leila Adriouch, Mathieu Nacher, Emilie Mosnier
No abstract text is available yet for this article.
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239891/cancer-burden-attributable-to-cigarette-smoking-among-hiv-infected-people-in-north-america
#14
Sean F Altekruse, Meredith S Shiels, Sharada P Modur, Stephanie R Land, Kristina A Crothers, Mari M Kitahata, Jennifer E Thorne, William C Mathews, Diana M Fernández-Santos, Angel M Mayor, John M Gill, Michael A Horberg, John T Brooks, Richard D Moore, Michael J Silverberg, Keri N Althoff, Eric A Engels
OBJECTIVE: With combination-antiretroviral therapy, HIV-infected individuals live longer with an elevated burden of cancer. Given the high prevalence of smoking among HIV-infected populations, we examined the risk of incident cancers attributable to ever smoking cigarettes. DESIGN: Observational cohort of HIV-infected participants with 270,136 person-years of follow-up in the North American AIDS Cohort Collaboration on Research and Design consortium. Among 52,441 participants; 2306 were diagnosed with cancer during 2000-2015...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239890/omega-3-decreases-interleukin-6-levels-in-hiv-and-hhv-8-co-infected-patients-results-from-a-randomized-supplementation-trial-in-uganda
#15
Anna E Coghill, Jeanette M Schenk, Zeina Mahkoul, Jackson Orem, Warren Phipps, Corey Casper
OBJECTIVE: Kaposi sarcoma (KS) is an HIV-associated malignancy caused by human herpesvirus-8 that occurs at highest incidence in sub-Saharan Africa. KS patients often present with inflammatory symptoms associated with higher mortality. DESIGN: We conducted a double-blind, randomized, placebo-controlled study in Uganda to test whether omega-3 (ω-3) supplementation could reduce inflammation in HIV and HHV-8 co-infected adults ≥ 18 years of age. Patients with acute illness, AIDS, or advanced KS were ineligible, as were pregnant women...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239889/are-trajectories-of-psychosocial-risk-in-adolescence-linked-to-hiv-vulnerability-in-emerging-and-young-adulthood-an-eighteen-year-longitudinal-study
#16
David Cordova, Justin Heinze, Hsing-Fang Hsieh, Ritesh Mistry, Christopher P Salas-Wright, Stephanie H Cook, Marc A Zimmerman
OBJECTIVES: To examine trajectories of adolescent psychosocial risk-drug use, depressive and anxiety symptoms, and violence victimization and observation-and the longitudinal relationship between psychosocial risk trajectories during adolescence and HIV risk behaviors in adulthood. METHODS: The eighteen-year longitudinal study was conducted from September 1994 through May 2013, in Michigan. Eight-hundred and fifty predominantly (80%) African American adolescents completed demographics and measures of drug use, depressive and anxiety symptoms, violence victimization and observation at Times 1-4, sexual risk behaviors at Times 5 and 6, and social conditions (i...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239888/eleven-year-incident-glucose-disorders-in-treated-hiv-infection-the-st-vincent-s-hiv-and-diabetes-study
#17
Chelsea N McMahon, Kathy Petoumenos, Karl Hesse, Andrew Carr, David A Cooper, Katherine Samaras
OBJECTIVES: To determine the long-term incidence of glucose disorders in treated HIV-infection, associations with traditional and HIV-specific risk factors and whether glycemic status predicts mortality. METHODS: Observational cohort of 104 men with treated HIV-infection and without diabetes, aged 43 ± 8y at baseline, with (mean ± SD) 11 8 ± 3 5y follow-up, with ascertainment of glucose status by fasting glucose or, in a subset (n = 33), a 75 g oral glucose tolerance test by 10-12 years follow-up...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29239887/incidence-of-sexually-transmitted-infections-before-and-after-pre-exposure-prophylaxis-for-hiv-a-cohort-study
#18
Vinh-Kim Nguyen, Zoë R Greenwald, Helen Trottier, Martha Cadieux, Alexandre Goyette, Mariève Beauchemin, Louise Charest, Danièle Longpré, Stéphane Lavoie, Hermione Gbego Tossa, Réjean Thomas
OBJECTIVE: Use of Pre-Exposure Prophylaxis (PrEP) for HIV raises concerns about sexually transmitted infection (STI) incidence due to decreased condom use among men who have sex with men (MSM). This study examines whether PrEP is associated with STIs in the 12-months following PrEP prescription relative to the 12-months prior to PrEP and if STI rates are higher among PrEP users relative to individuals receiving Post-Exposure Prophylaxis (PEP). DESIGN: Retrospective cohort study including PrEP users with >12 months of follow-up before PrEP prescription and individuals receiving PEP from 2010-2015 at Clinique l'Actuel (Montréal, Canada)...
December 12, 2017: AIDS
https://www.readbyqxmd.com/read/29194122/improving-postpartum-retention-in-care-for-women-living-with-hiv-in-the-united-states
#19
Florence M Momplaisir, Deborah Storm, Hervette Nkwihoreze, Olakunle Jayeola, John B Jemmott
: Research findings have consistently demonstrated that women living with HIV (WLWH) in the United States and globally experience declines in medication adherence and retention in care after giving birth. A number of studies have identified factors associated with postpartum retention in care, but the evidence base for interventions to address the problem and close this gap in the HIV care continuum is limited. Furthermore, the majority of studies have been conducted in low-or moderate resource countries and may be less applicable or require adaptation for use in high resource countries...
November 30, 2017: AIDS
https://www.readbyqxmd.com/read/29194121/hiv-infected-cannabis-users-have-lower-circulating-cd16-monocytes-and-ip-10-levels-compared-to-non-using-hiv-patients
#20
Michael D Rizzo, Robert B Crawford, Joseph E Henriquez, Yasser Aldhamen, Peter Gulick, Andrea Amalfitano, Norbert E Kaminski
OBJECTIVE: Chronic immune activation and elevated numbers of circulating activated monocytes (CD16) are implicated in HIV-associated neuroinflammation. The objective was to compare the level of circulating CD16 monocytes and interferon-γ-inducible protein 10 (IP-10) between HIV-infected cannabis users (HIV+MJ+) and non-cannabis users (HIV+MJ-), and determine whether in vitro Δ-Tetrahydrocannabinol (THC), a constituent of cannabis, affected CD16 expression as well as IP-10 production by monocytes...
November 30, 2017: AIDS
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