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AIDS

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https://www.readbyqxmd.com/read/28426535/frailty-in-hiv-infected-people-a-new-risk-factor-for-bone-mineral-density-loss
#1
Sylvie Bregigeon, Anne Galinier, Olivia Zaegel-Faucher, Carla E Cano, Véronique Obry, Hélène Laroche, Sophie Trijau, Armelle Saout, Isabelle Poizot-Martin
OBJECTIVE: This study aims to assess the association between bone mineral density (BMD) and frailty in a cohort of HIV-infected patients. DESIGN: A cross-sectional study in an HIV outpatient unit where nearly 1,000 patients are monitored. METHODS: Subjects undergoing bone densitometry were proposed an evaluation of frailty using criteria of the Cardiovascular Health Study (CHS) and the Study of Osteoporotic Fractures (SOF). Frailty markers (FM) were weight-loss, self-reported exhaustion, physical activity, grip strength, chair stands, and slow gait...
April 19, 2017: AIDS
https://www.readbyqxmd.com/read/28426534/age-disparate-relationships-and-hiv-incidence-in-adolescent-girls-and-young-women-evidence-from-a-general-population-cohort-in-zimbabwe
#2
Robin Schaefer, Simon Gregson, Jeffrey W Eaton, Owen Mugurungi, Rebecca Rhead, Albert Takaruza, Rufurwokuda Maswera, Constance Nyamukapa
OBJECTIVE: Age-disparate sexual relationships with older men may drive high rates of HIV acquisition in young women in sub-Saharan Africa but evidence is limited. We investigate the association between age-disparate relationships and HIV incidence in Manicaland, Zimbabwe. DESIGN: A general-population open-cohort study (six surveys) (1998-2013). METHODS: 3746 young women aged 15-24 years participated in consecutive surveys and were HIV-negative at the beginning of inter-survey periods...
April 19, 2017: AIDS
https://www.readbyqxmd.com/read/28426533/hiv-dna-content-in-different-cd4-t-cell-subsets-correlates-with-cd4-cd8-ratio-or-length-of-efficient-treatment
#3
Lara Gibellini, Simone Pecorini, Sara de Biasi, Elena Bianchini, Margherita Digaetano, Marcello Pinti, Gianluca Carnevale, Vanni Borghi, Giovanni Guaraldi, Cristina Mussini, Andrea Cossarizza, Milena Nasi
OBJECTIVES: HIV establishes a latent infection at different degrees within naïve (TN) or central (TCM) and effector memory (TEM) CD4+ T cell. Studying patients in whom HIV production was suppressed by combined antiretroviral therapy (cART), our main aim was to find which factors are related or can influence intracellular viral reservoir in different CD4+ T cell subsets. METHODS: We enrolled 32 HIV+ patients successfully treated for > 2 years, with a CD4+ T cell count > 500 cells/μL and plasma viremia undetectable from at least one year...
April 19, 2017: AIDS
https://www.readbyqxmd.com/read/28426532/impact-of-co-morbidity-and-aging-on-health-related-quality-of-life-in-hiv-positive-and-hiv-negative-individuals
#4
N Langebeek, K W Kooij, F W Wit, I G Stolte, M A G Sprangers, P Reiss, P T Nieuwkerk
BACKGROUND: HIV-infected individuals may be at risk for the premature onset of age-associated non-communicable co-morbidities. Being HIV-positive, having comorbidities and being of higher age may adversely impact health-related quality of life (HRQL). We investigated the possible contribution of HIV infection, co-morbidities, and age on HRQL and depression. METHODS: HIV-infected individuals and uninfected controls from the AGEhIV Cohort Study were screened for the presence of co-morbidities...
April 19, 2017: AIDS
https://www.readbyqxmd.com/read/28398960/prevalence-and-risk-factors-of-non-alcoholic-fatty-liver-disease-in-hiv-monoinfection-a-systematic-review-and-meta-analysis
#5
James B Maurice, Amee Patel, Alasdair J Scott, Krish Patel, Mark Thursz, Maud Lemoine
OBJECTIVE: to identify the prevalence and risk factors of NAFLD, NASH and fibrosis in HIV-monoinfected patients. DESIGN: Systematic review and meta-analysis. METHODS: We searched Medline and Embase and included studies that enrolled HIV-monoinfected patients with NAFLD defined by imaging and/or liver histology. Data on prevalence and risk factors for NAFLD, NASH and fibrosis were collected for meta-analysis using random effects models. RESULTS: Ten studies were included from USA (n = 4), Canada (n = 1), France (n = 2), Italy (n = 1), Japan (n = 1) and China (n = 1)...
April 10, 2017: AIDS
https://www.readbyqxmd.com/read/28398959/emergence-of-untreatable-multidrug-resistant-hiv-1-in-patients-failing-second-line-therapy-in-kenya
#6
Seth C Inzaule, Raph L Hamers, Irene Mukui, Kennedy Were, Prestone Owiti, Daniel Kwaro, Tobias F Rinke de Wit, Clement Zeh
: We performed a countrywide assessment of HIV drug resistance among 123 patients with virological failure on second-line antiretroviral therapy (ART) in Kenya. The percentage of patients harboring intermediate-to-high-level resistance was 27% for lopinavir-ritonavir, 24% for atazanavir-ritonavir and 7% for darunavir-ritonavir, and 25% had complete loss of activity to all available first- and second-line drugs. Overall, one in four patients failing second-line ART have completely exhausted available antiretrovirals in Kenya, highlighting the need for increased access to third-line drugs...
April 10, 2017: AIDS
https://www.readbyqxmd.com/read/28398958/new-onset-diabetes-in-hiv-treated-adults-from-thailand-predictors-long-term-renal-and-cardiovascular-outcomes
#7
Opass Putcharoen, Lalita Wattanachanya, Jiratchaya Sophonphan, Sarawut Siwamogsatham, Vorapot Sapsirisavat, Sivaporn Gatechompol, Supalak Phonphithak, Stephen J Kerr, Yingyos Avihingsanon, Kiat Ruxrungtham, Anchalee Avihingsanon
OBJECTIVE: To determine the incidence and risk factors for developing diabetes mellitus (DM) in a cohort of Thai HIV-infected patients on long-term combination antiretroviral therapy (cART). DESIGN: Prospective study conducted between July 1996-April 30, 2015. METHODS: 1,748 subjects (60% males) who did not have DM prior to ART were assessed twice a year. Incident DM was defined as either having two consecutive fasting glucose levels >126 mg/dL, or reporting anti-DM medication/ DM diagnosis after starting cART...
April 10, 2017: AIDS
https://www.readbyqxmd.com/read/28398957/association-of-hiv-diagnosis-rates-and-laws-criminalizing-hiv-exposure-in-the-united-states
#8
Patricia Sweeney, Simone C Gray, David W Purcell, Jenny Sewell, Aruna Surendera Babu, Brett A Tarver, Joseph Prejean, Jonathan Mermin
OBJECTIVE: To assess whether state criminal exposure laws are associated with HIV and stage 3 (AIDS) diagnosis rates in the United States. DESIGN: We assessed the relationship between HIV and stage 3 (AIDS) diagnosis data from the National HIV Surveillance System and the presence of a state criminal exposure law as identified through WestlawNext by using generalized estimating equations. METHODS: We limited analysis to persons aged ≥13 years with diagnosed HIV infection or AIDS reported to the National HIV Surveillance System of the Centers for Disease Control and Prevention...
April 10, 2017: AIDS
https://www.readbyqxmd.com/read/28398956/informatic-interrogation-of-csf-proteomic-profiles-from-hiv-infected-subjects-implicates-acute-phase-and-complement-systems-in-shifting-cognitive-status
#9
Ceereena Ubaida-Mohien, Benjamin Lamberty, Alex M Dickens, Michelle M Mielke, Thomas Marcotte, Ned Sacktor, Igor Grant, Scott Letendre, D Franklin, Pawel Cibrowski, Ravi Tharakan, Justin C McArthur, Howard Fox, Norman J Haughey
The prevalence of HIV-Associated Neurocognitive Disorders (HAND) has not changed considerably in the last two decades. Potent antiretroviral therapy (ART) has shifted the severity of HAND to milder phenotypes, but excess morbidity and mortality continue to be associated with HAND. Changes in numerous markers of immune function, inflammation and cellular stress have been repeatedly associated with HAND but the underlying systems that drive these changes have not been identified. In this study we used systems informatics to interrogate the CSF proteomic content of longitudinal samples obtained from HIV-infected adults with stably unimpaired, stably impaired, worsening, or improving neurocognitive (NC) performance...
April 10, 2017: AIDS
https://www.readbyqxmd.com/read/28398955/does-art-change-partnership-dynamics-and-hiv-risk-behaviours-among-plwh-a-cohort-study-in-kwazulu-natal-south-africa
#10
Nuala McGrath, Erofili Grapsa
OBJECTIVE: We explore the impact of antiretroviral therapy (ART) on partnership acquisition and dissolution rates and changes in sexual behaviours among HIV-infected adults. DESIGN: Using detailed longitudinal data from a prospective cohort of HIV-infected adults with CD4<200 cell/ml (ART-eligible) or CD4>500 cell/ml (pre-ART) conducted in rural KwaZulu-Natal, South Africa, 2009-2012. METHODS: Partnership acquisition and dissolution are explored through survival analysis methods, while generalized linear models were fitted for the sexual behaviour outcomes with interaction terms to allow the association with ART to vary over time...
April 10, 2017: AIDS
https://www.readbyqxmd.com/read/28398954/moving-towards-test-and-start-learning-from-the-experience-of-universal-art-programs-for-hiv-infected-pregnant-breastfeeding-women
#11
Sara E Forhan, Surbhi Modi, James C Houston, Laura N Broyles
: In 2015, the World Health Organization (WHO) recommended universal antiretroviral therapy (ART) for all people living with HIV (PLHIV) after two randomized controlled trials revealed lower rates of mortality and serious illnesses among PLHIV receiving immediate ART compared to those receiving deferred ART. Many countries in sub-Saharan Africa rapidly adopted this guidance and are implementing "test and start" programs.As this work begins, lessons learned from prevention of mother-to-child transmission (PMTCT) Option B+ programs can inform decisions for new universal HIV treatment programs...
April 10, 2017: AIDS
https://www.readbyqxmd.com/read/28375875/emergent-drug-resistance-with-integrase-strand-transfer-inhibitor-based-regimens-incidence-and-risk-factors
#12
Katherine J Lepik, P Richard Harrigan, Benita Yip, Lu Wang, Marjorie A Robbins, Wendy W Zhang, Junine Toy, Linda Akagi, Viviane Dias Lima, Silvia Guillemi, Julio S G Montaner, Rolando Barrios
OBJECTIVES: To estimate the incidence of and risk factors for emergent resistance to integrase inhibitors (INSTI) and nucleoside(-tide) reverse transcriptase inhibitors (NRTI) in HIV-1-infected adults receiving an INSTI plus two NRTIs. DESIGN: Retrospective cohort study. METHODS: Persons ≥19 years were included if they received their first prescription for raltegravir, elvitegravir or dolutegravir in British Columbia, Canada in 2012-2014, and were followed to 31-Dec-2015...
April 3, 2017: AIDS
https://www.readbyqxmd.com/read/28375874/immune-reconstitution-inflammatory-syndrome-associated-with-toxoplasmic-encephalitis-in-hiv-infected-patients-a-multicenter-cohort-study
#13
Ward P H van Bilsen, Charlotte H S B van den Berg, Bart J A Rijnders, Kees Brinkman, Jan W Mulder, Luc B S Gelinck, Andy I M Hoepelman, Ferdinand W N M Wit, Diederik van de Beek, Jan M Prins
OBJECTIVES: To investigate the incidence and risk factors of immune reconstitution inflammatory syndrome (IRIS) associated with toxoplasmic encephalitis (TE) in patients starting cART. DESIGN: A historical multicenter cohort study. METHODS: We included all HIV-infected patients diagnosed with TE in six Dutch hospitals between 1996 and 2016. Diagnosis of TE-IRIS was made using predefined IRIS criteria. We distinguished paradoxical TE-IRIS (worsening of underlying treated infection) from unmasking TE-IRIS (unmasking of subclinical infection after start of cART)...
April 3, 2017: AIDS
https://www.readbyqxmd.com/read/28375873/an-increased-rate-of-fracture-occurs-a-decade-earlier-in-hiv-compared-to-hiv-men-in-the-multicenter-aids-cohort-study-macs
#14
Anda Gonciulea, Ruibin Wang, Keri N Althoff, Frank J Palella, Jordan Lake, Lawrence A Kingsley, Todd T Brown
OBJECTIVES: To determine the incidence and age-related fracture risk among HIV-infected (HIV+) and uninfected men (HIV-). To evaluate factors independently associated with fracture risk. DESIGN: Prospective, multicenter cohort study of men with or at risk for HIV. METHODS: Outcome measures: 1) all fractures (excluding skull, face, digits) and 2) fragility fractures (vertebral column, femur, wrist, humerus) were collected semiannually in 1221 HIV+ and 1408 HIV- men ≥ age 40...
April 3, 2017: AIDS
https://www.readbyqxmd.com/read/28358742/similar-effectiveness-of-direct-acting-antiviral-against-hepatitis-c-virus-in-patients-with-and-without-hiv-infection
#15
María Luisa Montes, Antonio Olveira, Adriana Ahumada, Teresa Aldamiz, Javier García-Samaniego, Ana Clemente, Juan Berenguer, Juan González-García, Luz Martín-Carbonero
OBJECTIVE: We compared the baseline characteristics, effectiveness, and tolerance of DAA-based regimens taken by HCV-monoinfected and HCV-HIV-coinfected individuals in clinical practice. DESIGN: We performed a prospective observational study in 2 tertiary centers in Madrid, Spain that included all HCV-monoinfected and HCV/HIV-coinfected patients undergoing HCV treatment with all-oral DAA regimens in a routine clinical setting from April 2015 to November 2015. We evaluated sustained virological response 12 weeks after the end of therapy (SVR12), adverse events (AEs), and baseline and treatment characteristics...
March 29, 2017: AIDS
https://www.readbyqxmd.com/read/28358741/novel-genetic-associations-and-gene-gene-interactions-of-chemokine-receptor-and-chemokine-genetic-polymorphisms-in-hiv-aids
#16
Jacqueline M Valverde-Villegas, Rúbia Marília De Medeiros, Karine Pereira de Andrade, Vanessa Cristina Jacovas, Breno Riegel Dos Santos, Daniel Simon, Sabrina Esteves de Matos Almeida, José Artur Bogo Chies
OBJECTIVE: To investigate the influence of candidate polymorphisms on chemokine receptor/ligand genes on HIV infection and AIDS progression (HIV/AIDS). DESIGN: Fifteen polymorphisms of the CCR3, CCR4, CCR5, CCR6, CCR8, CXCR3, CXCR6, CCL20, CCL22 and CXCL10 genes were analysed in 206 HIV-positive subjects classified as rapid progressors (RPs; n = 40), or non-RPs (NRPs; n = 166) and in 294 HIV-seronegative subjects. METHODS: The polymorphisms were genotyped using minisequencing...
March 29, 2017: AIDS
https://www.readbyqxmd.com/read/28358740/croi-2017-highlights
#17
Kristin N Harper
No abstract text is available yet for this article.
March 29, 2017: AIDS
https://www.readbyqxmd.com/read/28358739/hiv-infection-has-no-prognostic-impact-on-advanced-stage-hodgkin-lymphoma-treated-with-doxorubicin-bleomycin-vinblastine-and-dacarbazine
#18
Marc Sorigué, Olga García, Gustavo Tapia, Maria J Baptista, Miriam Moreno, José-Luis Mate, Juan M Sancho, Evarist Feliu, Josep-Maria Ribera, José-Tomás Navarro
OBJECTIVE: Classical Hodgkin lymphoma (cHL) is a non-AIDS-defining cancer with good response to chemotherapy in the combined antiretroviral therapy (cART) era. The aim of the study was to compare the characteristics, the response with treatment and survival of advanced-stage cHL treated with adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) between cART-treated HIV-positive and HIV-negative patients. DESIGN AND METHODS: We retrospectively analyzed advanced-stage cHL patients from a single institution, uniformly treated with ABVD...
March 29, 2017: AIDS
https://www.readbyqxmd.com/read/28358738/%C3%AE-7-nicotinic-acetylcholine-receptor-inhibition-by-indinavir-implications-for-cognitive-dysfunction-in-treated-hiv-disease
#19
Sean Ekins, Paul Mathews, Erin K Saito, Natalie Diaz, David Naylor, Julia Chung, Aaron M McMurtray
OBJECTIVE: This study set out to determine if the human immunodeficiency virus (HIV) protease inhibitor, indinavir, alters responsiveness of α7-nicotinic acetylcholine receptors to acetylcholine. DESIGN: Treatment with highly active antiretroviral therapy has dramatically reduced development of HIV associated dementia and more severe forms of cognitive impairment. However, many individuals continue to experience cognitive decline of uncertain etiology. Previous studies have failed to demonstrate significant alterations of functional brain connectivity, structural brain changes, or changes in cerebral blood flow sufficient to explain cognitive decline in virally suppressed individuals...
March 29, 2017: AIDS
https://www.readbyqxmd.com/read/28358737/delay-in-sexual-maturation-in-perinatally-hiv-infected-youth-is-mediated-by-poor-growth
#20
Andrea Bellavia, Paige L Williams, Linda A Dimeglio, Rohan Hazra, Mark J Abzug, Kunjal Patel, Denise L Jacobson, Russell B Van Dyke, Mitchell E Geffner
OBJECTIVE: To evaluate the association between HIV infection and sexual maturation, and mediation of this association by HIV effects on growth. DESIGN: Pooled data were analyzed from two longitudinal cohort studies, the IMPAACT P219/219C Study (1993-2007) and the PHACS Adolescent Master Protocol (2007-2015), including perinatally HIV-infected (PHIV) and HIV-exposed uninfected (PHEU) youth. METHODS: We evaluated age at sexual maturity among 2539 PHIV and PHEU adolescents based on annual physician-assessed pubertal staging measures...
March 29, 2017: AIDS
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