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https://www.readbyqxmd.com/read/27902508/cabotegravir-long-acting-injection-protects-macaques-against-intravenous-challenge-with-sivmac251
#1
Chasity D Andrews, Leslie S T Bernard, Amanda Yee Poon, Hiroshi Mohri, Natanya Gettie, William R Spreen, Agegnehu Gettie, Kasi Russell-Lodrigue, James Blanchard, Zhi Hong, David D Ho, Martin Markowitz
OBJECTIVE: We evaluated the effectiveness of cabotegravir (CAB; GSK1265744 or GSK744) long-acting (LA) as pre-exposure prophylaxis (PrEP) against intravenous SIV challenge in a model that mimics blood transfusions based on the per-act probability of infection. DESIGN: CAB LA is an InSTI formulated as a 200 mg/mL injectable nanoparticle suspension that is an effective pre-exposure prophylaxis (PrEP) agent against rectal and vaginal SHIV transmission in macaques...
November 29, 2016: AIDS
https://www.readbyqxmd.com/read/27902507/smoking-hiv-and-risk-of-pregnancy-loss
#2
Daniel Westreich, Jordan Cates, Mardge Cohen, Kathleen M Weber, Dominika Seidman, Karen Cropsey, Rodney Wright, Joel Milam, Mary A Young, C Christina Mehta, Deborah R Gustafson, Margaret A Fischl, Adaora A Adimora
OBJECTIVE: Cigarette smoking during pregnancy increases risks of poor pregnancy outcomes including miscarriage and stillbirth (pregnancy loss), but the effect of smoking on pregnancy loss among HIV-infected women has not been explored. Here, investigated the impact of smoking on risk of pregnancy loss among HIV-positive and HIV-negative women, and estimated the potential impact of realistic smoking cessation interventions on risk of pregnancy loss among HIV-positive women. DESIGN: We analyzed pregnancy outcomes in HIV-positive and HIV-negative participants in the Women's Interagency HIV Study (WIHS) between 1994 and 2014...
November 29, 2016: AIDS
https://www.readbyqxmd.com/read/27835621/interpreting-the-influence-of-race-and-cognitive-activity-on-neurocognition-in-adults-aging-with-hiv
#3
David E Vance
No abstract text is available yet for this article.
November 9, 2016: AIDS
https://www.readbyqxmd.com/read/27835619/hla-g-hiv-1-specific-cd8-t-cells-are-associated-with-hiv-1-immune-control
#4
Selena Viganò, Jordi J Negrón, Samantha Tse, Fatema Z Chowdhury, Mathias Lichterfeld, Xu G Yu
OBJECTIVE(S): To assess the frequency and function of HIV-1-specific HLA-G CD8 T cells in HIV-1 controllers and progressors. DESIGN: We performed an observational cross-sectional cohort analysis in untreated (n = 47) and treated (n = 17) HIV-1 patients with different rates of disease progression and n = 14 healthy individuals. METHODS: We evaluated the frequency, the proportion and the function of total and virus-specific HLA-G CD8 T cells by tetramer or intracellular cytokine staining, followed by flow cytometric analysis...
November 9, 2016: AIDS
https://www.readbyqxmd.com/read/27835618/increased-glucose-transporter-1-expression-on-intermediate-monocytes-from-hiv-infected-women-with-subclinical-cardiovascular-disease
#5
Tiffany R Butterfield, David B Hanna, Robert C Kaplan, Jorge R Kizer, Helen G Durkin, Mary A Young, Marek J Nowicki, Phyllis C Tien, Elizabeth T Golub, Michelle A Floris-Moore, Kehmia Titanji, Margaret A Fischl, Sonya L Heath, Jefferey Martinson, Suzanne M Crowe, Clovis S Palmer, Alan L Landay, Joshua J Anzinger
OBJECTIVE: People living with HIV (PLWH) have chronic immune activation and increased cardiovascular disease (CVD) risk. Activation of monocytes and T lymphocytes causes up-regulation of glucose transporter-1 (GLUT1) for efficient function. PLWH have an increased percentage of GLUT1-expressing monocytes and T lymphocytes, but it is unclear if these cells are associated with CVD. We evaluated expression of GLUT1 and CD38 on monocyte and T lymphocyte populations from HIV-infected women with subclinical CVD...
November 9, 2016: AIDS
https://www.readbyqxmd.com/read/27835616/association-of-cognitive-activity-and-neurocognitive-function-in-blacks-and-whites-with-hiv
#6
Kristin R Krueger, Oluwatoyian Adeyemi, Sue Leurgans, Raj C Shah, Antonio D Jimenez, Lawrence Ouellet, Alan L Landay, David A Bennett, Lisa L Barnes
OBJECTIVE: Older persons with HIV are at risk for impaired cognition, yet there is limited information on modifiable factors associated with neurocognitive function in this group. DESIGN: This is a cross-sectional observational study of cognitive activities and neurocognitive function. METHODS: We examined the relation between frequency of cognitive activity and current neurocognitive performance in 176 older persons with HIV (70% African American, 76% male; mean age = 58...
November 9, 2016: AIDS
https://www.readbyqxmd.com/read/27835615/modulation-of-innate-and-adaptive-cellular-immunity-relevant-to-hiv-1-vaccine-design-by-seminal-plasma
#7
Kevin J Selva, Stephen J Kent, Matthew S Parsons
OBJECTIVES: Mucosal exposure to HIV-1 infection generally occurs in the presence of semen. Immunomodulation by seminal plasma (SP) is well described in the reproductive biology literature. Little is known, however, about the impact of SP on innate and adaptive anti-HIV-1 cellular immunity. DESIGN: This study investigated the effects of SP on immune responses considered important for prophylactic HIV-1 vaccine development, namely innate and adaptive cellular immunity mediated by NK cells and T-cells, respectively...
November 9, 2016: AIDS
https://www.readbyqxmd.com/read/27835614/depression-at-antiretroviral-therapy-initiation-and-clinical-outcomes-among-a-cohort-of-tanzanian-women-living-with-hiv
#8
Christopher R Sudfeld, Sylvia Kaaya, Nilupa S Gunaratna, Fedinand Mugusi, Wafaie W Fawzi, Said Aboud, Mary C Smith Fawzi
OBJECTIVE: The objective of the study was to assess the relationship of depression at antiretroviral therapy (ART) initiation with mortality and clinical outcomes among Tanzanian women living with HIV. DESIGN: We conducted a prospective cohort study of 1,487 women who initiated ART in Dar es Salaam, Tanzania. METHODS: Symptoms of depression and anxiety were assessed using a Tanzanian adapted and validated version of the Hopkins Symptom Checklist (HSCL-25)...
November 9, 2016: AIDS
https://www.readbyqxmd.com/read/27828785/early-age-at-start-of-antiretroviral-therapy-associated-with-better-virologic-control-after-initial-suppression-in-hiv-infected-infants
#9
Stephanie Shiau, Renate Strehlau, Karl-Günter Technau, Faeezah Patel, Stephen M Arpadi, Ashraf Coovadia, Elaine J Abrams, Louise Kuhn
OBJECTIVE: The report of the 'Mississippi baby' who was initiated on antiretroviral therapy (ART) within 30 h of birth and maintained viral suppression off ART for 27 months has increased interest in the timing of ART initiation early in life. We examined associations between age at ART initiation and virologic outcomes in five cohorts of HIV-infected infants and young children who initiated ART before 2 years of age in Johannesburg, South Africa. METHODS: We compared those who initiated ART early (<6 months of age) and those who started ART late (6-24 months of age)...
November 8, 2016: AIDS
https://www.readbyqxmd.com/read/27831953/life-expectancy-in-hiv-positive-persons-in-switzerland-matched-comparison-with-general-population
#10
Aysel Gueler, André Moser, Alexandra Calmy, Huldrych F Günthard, Enos Bernasconi, Hansjakob Furrer, Christoph A Fux, Manuel Battegay, Matthias Cavassini, Pietro Vernazza, Marcel Zwahlen, Matthias Egger
OBJECTIVES: To estimate life expectancy (LE) over 25 years in HIV-positive people and compare their LE with recent estimates for the general population, by education. METHODS: Patients aged 20 years or older enrolled in the Swiss HIV Cohort Study 1988-2013 were eligible. Patients alive in 2001 were matched to up to 100 Swiss residents, by sex, year of birth, and education. LE at age 20 was estimated for monotherapy (1988-1991), dual therapy (1992-1995), early combination antiretroviral therapy (cART, 1996-1998), later cART (1999-2005) and recent cART (2006-2013) eras...
November 7, 2016: AIDS
https://www.readbyqxmd.com/read/27831952/tenofovir-disoproxil-fumarate-safety-for-women-and-their-infants-during-pregnancy-and-breastfeeding-systematic-review
#11
Lynne M Mofenson, Rachel C Baggaley, Ioannis Mameletzis
OBJECTIVES: Pregnant/lactating women in some sub-Saharan Africa settings are at substantial risk of HIV acquisition and could benefit from pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF), but safety data in pregnancy/lactation are limited. DESIGN: Systematic data review through August 2016. METHODS: We reviewed research reports/conference abstracts with maternal/child adverse outcome data in HIV-infected and HIV-uninfected pregnant/lactating women receiving TDF alone or in combination with other drugs compared with non-TDF regimens...
November 7, 2016: AIDS
https://www.readbyqxmd.com/read/27831951/use-of-via-pap-smear-or-hr-hpv-testing-in-women-living-with-hiv-aids-for-post-treatment-cervical-cancer-screening-same-tests-different-priorities
#12
Omenge Orang'o, Tao Liu, Astrid Christoffersen-Deb, Peter Itsura, John Oguda, Sierra Washington, David Chumba, Latha Pisharodi, Susan Cu-Uvin, Anne F Rositch
OBJECTIVES: Few studies have addressed optimal follow-up for HIV-infected women after cervical treatment. This study aimed to compare performance of three available tests to detect post-treatment cervical disease in HIV-infected women in Kenya. DESIGN: This is a prospective cohort study. METHODS: At least six months following cryotherapy, 517 HIV-infected women were evaluated concurrently with VIA, Pap smear, and HR-HPV testing. Women positive by any test (≥LSIL for Pap) were scheduled for colposcopy and biopsy...
November 7, 2016: AIDS
https://www.readbyqxmd.com/read/27831950/partner-services-in-adults-with-acute-and-early-hiv-infection-san-diego-1996-2014
#13
Nella Green, Martin Hoenigl, Antoine Chaillon, Christy M Anderson, Sergei L Kosakovsky Pond, Davey M Smith, Susan J Little
BACKGROUND: To examine the yield of HIV partner services provided to persons newly diagnosed with acute and early HIV infection (AEH) in San Diego, United States. DESIGN: Observational cohort study. METHODS: The study investigated the yield (i.e. number of new HIV and AEH diagnoses, genetically linked partnerships, and high risk uninfected partners) of partner services (confidential contact tracing) for individuals with AEH enrolled in the San Diego Primary Infection Resource Consortium 1996 - 2014...
November 7, 2016: AIDS
https://www.readbyqxmd.com/read/27831949/sex-differences-in-the-association-of-hiv-infection-with-hepatic-steatosis
#14
Ani Kardashian, Yifei Ma, Rebecca Scherzer, Jennifer C Price, Monika Sarkar, Natalie Korn, Kyle Tillinghast, Marion G Peters, Susan M Noworolski, Phyllis C Tien
BACKGROUND: Hepatic steatosis is increasing worldwide. Whether HIV and its associated metabolic perturbations exacerbate steatosis is unclear. Sex differences in adipose tissue distribution may also affect steatosis risk. We examined the contribution of HIV and sex to steatosis. METHODS: Using magnetic resonance imaging and spectroscopy, visceral adipose tissue (VAT) and liver fat fraction (LFF) were measured in 121 HIV-infected and 107 uninfected men and women without viral hepatitis...
November 7, 2016: AIDS
https://www.readbyqxmd.com/read/27831948/hiv-surveillance-combining-an-assay-for-identification-of-very-recent-infection-and-phylogenetic-analyses-on-dried-spots
#15
Denys Brand, Jean Capsec, Antoine Chaillon, Françoise Cazein, Stéphane Le Vu, Alain Moreau, Josiane Pillonel, Sylvie Brunet, Damien Thierry, Leslie Guillon-Grammatico, Florence Lot, Francis Barin
BACKGROUND: Transmitted/founder (T/F) viruses isolated at the early stage of infection are indicators of the variants that are spreading within a population. The French reporting system for new HIV diagnoses is linked to a virological surveillance using dried serum spots (DSS). METHODS: We combined an immunoassay for very recent infection (VRI < 31 days) to a phylogenetic analysis of T/F viruses and sociodemographic information to analyze the dynamics of the HIV-1 epidemic during a 3-year period...
November 7, 2016: AIDS
https://www.readbyqxmd.com/read/27831947/an-epidemiological-modelling-study-to-estimate-the-composition-of-hiv-positive-populations-including-migrants-from-endemic-settings-an-application-in-the-uk
#16
Fumiyo Nakagawa, Andrew Phillips
OBJECTIVE: Migrants account for a significant number of people living with HIV in Europe, and it is important to fully consider this population in national estimates. Using a novel approach with the UK as an example, we present key public health measures of the HIV epidemic, taking into account both in-country infections and infections likely to have been acquired abroad. DESIGN: Mathematical model calibrated to extensive data sources. METHODS: An individual-based stochastic simulation model is used to calibrate to routinely collected surveillance data in the UK...
November 7, 2016: AIDS
https://www.readbyqxmd.com/read/27831946/rates-and-predictors-of-injury-in-a-population-based-cohort-of-people-living-with-hiv-trends-and-disparities-from-1996-to-2013
#17
Hasina Samji, Wendy Zhang, Oghenowede Eyawo, Shahab Jabbari, Guillaume Colley, Zach Tanner, Mark Hull, Julio S G Montaner, Robert S Hogg
OBJECTIVES: Injuries are responsible for 10% of the global burden of disease; however, the epidemiology of injury among people living with HIV (PLHIV) has not been well-elucidated. This study seeks to characterize rates and predictors of injury among PLHIV compared to the general population in British Columbia (BC), Canada. DESIGN: A population-based dataset was created via linkage between the BC Centre for Excellence in HIV/AIDS and PopulationDataBC. METHODS: PLHIV aged 20 years and older were compared to a random 10% sample of the adult general population...
November 7, 2016: AIDS
https://www.readbyqxmd.com/read/27831945/the-lorenz-curve-a-novel-method-for-understanding-viral-load-distribution-at-the-population-level
#18
Katerina Christopoulos, Wendy Hartogensis, David V Glidden, Christopher D Pilcher, Monica Gandhi, Elvin H Geng
Existing HIV care cascade metrics fail to capture whether viremia is equally distributed in a population or concentrated within groups. We applied the Lorenz cure, which has been used to describe disparities in the distribution of income and other resources, to the distribution of viremia in a safety-net HIV clinic in 2012. Among 1,855 established clinic patients, 1% of the population held 50% of the virus and 10% of the population held 94% of virus.
November 7, 2016: AIDS
https://www.readbyqxmd.com/read/27819802/immediate-initiation-of-cart-is-associated-with-lower-levels-of-cerebrospinal-fluid-ykl-40-a-marker-of-microglial-activation-in-hiv-1-infection
#19
Michael J Peluso, Victor Valcour, Nittaya Phanuphak, Jintanat Ananworanich, James Lk Fletcsher, Thep Chalermchai, Shelly J Krebs, Merlin L Robb, Joanna Hellmuth, Magnus Gisslén, Henrik Zetterberg, Serena Spudich
OBJECTIVE: To characterize cerebrospinal fluid (CSF) YKL-40, a unique biomarker that reflects activation of microglial cells, in acute (AHI) and chronic HIV-1 infection (CHI) and to determine the effect of treatment initiation on levels of this marker. DESIGN: Cross-sectional study of two groups of HIV-infected participants at baseline and follow-up timepoints. METHODS: AHI (n = 33) and CHI (n = 34) participants underwent CSF and blood sampling before treatment initiation with combination antiretroviral therapy (cART) and at follow up on cART in a subset of these individuals (6 months in AHI participants [n = 24], 1 year in CHI participants [n = 10])...
November 2, 2016: AIDS
https://www.readbyqxmd.com/read/27776040/the-effects-of-hiv-on-fertility-by-infection-duration-evidence-from-african-population-cohorts-before-art-availability-fertility-by-duration-of-hiv-infection
#20
Milly Marston, Jessica Nakiyingi-Miiro, Sylvia Kusemererwa, Mark Urassa, Denna Michael, Constance Nyamukapa, Simon Gregson, Basia Zaba, Jeffrey W Eaton
OBJECTIVES: To estimate the relationship between HIV natural history and fertility by duration of infection in East and Southern Africa before the availability of antiretroviral therapy, and assess potential biases in estimates of age-specific sub-fertility when using retrospective birth histories in cross-sectional studies. DESIGN: Pooled analysis of prospective population-based HIV cohort studies in Masaka (Uganda) Kisesa (Tanzania), and Manicaland (Zimbabwe)...
October 20, 2016: AIDS
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