journal
MENU ▼
Read by QxMD icon Read
search

AIDS

journal
https://www.readbyqxmd.com/read/28121714/hepatitis-delta-and-hiv-infection
#1
Vincent Soriano, Kenneth E Sherman, Pablo Barreiro
Viral liver diseases are frequent co-morbidities and major contributors to death in HIV-positive individuals on antiretroviral therapy. Whereas cure of hepatitis C and control of hepatitis B with antivirals avert liver disease progression in most HIV-coinfected patients, the lack of satisfactory treatment for hepatitis delta virus (HDV) infection remains a major threat for developing cirrhosis and liver cancer in this population. In the European Union and North America, sexual contact has replaced injection drug use has major transmission route for HDV in HIV-positive persons...
January 24, 2017: AIDS
https://www.readbyqxmd.com/read/28121713/a-novel-hiv-1-gp41-tripartite-model-for-rational-design-of-hiv-1-fusion-inhibitors-with-improved-antiviral-activity
#2
Shan Su, Qian Wang, Wei Xu, Fei Yu, Chen Hua, Yun Zhu, Shibo Jiang, Lu Lu
OBJECTIVES: During HIV-1 fusion process, the N-terminal heptad repeat (NHR) of the HIV-1 gp41 interacts with the C-terminal heptad repeat (CHR) to form the fusion active 6-helix bundle (6-HB), thus being an effective target for the design of CHR-peptide-based HIV-1 fusion inhibitors. To overcome the limitations of the simplified helix wheel model of 6-HB, we herein developed a novel HIV-1 gp41 NHR-CHR-NHR tripartite model for the rational design of HIV-1 fusion inhibitors with improved antiviral activities...
January 24, 2017: AIDS
https://www.readbyqxmd.com/read/28121712/elevated-cytomegalovirus-igg-antibody-levels-are-associated-with-hiv-1-disease-progression-and-immune-activation
#3
Eshan U Patel, Sara Gianella, Kevin Newell, Aaron A R Tobian, Allison R Kirkpatrick, Fredrick Nalugoda, Mary K Grabowski, Ronald H Gray, David Serwadda, Thomas C Quinn, Andrew D Redd, Steven J Reynolds
OBJECTIVE: To assess the association between CMV IgG antibody levels, HIV disease progression, and immune activation in sub-Saharan Africa. DESIGN: A prospective cohort study was conducted among women enrolled in a trial that was designed to determine the effect of acyclovir on HIV disease progression in Rakai, Uganda. METHODS: The primary endpoints were progression to a CD4 T-cell count<250 cells/μL, non-traumatic death, or initiation of ART...
January 24, 2017: AIDS
https://www.readbyqxmd.com/read/28121711/hepatocellular-carcinoma-an-evolving-challenge-in-viral-hepatitis-and-hiv-co-infection
#4
David J Pinato, Alessia Dalla Pria, Rohini Sharma, Mark Bower
Liver-related morbidity and mortality is expanding in people living with HIV (PLHIV). Hepatocellular carcinoma (HCC), the third most lethal malignancy on a global scale, is a dominant complication of chronic liver disease and cirrhosis in patients with coexisting hepatitis. HIV infection further complicates the clinical heterogeneity of HCC posing concurrent challenges stemming from the underlying immunological status of the patients and the ongoing need for combined anti-retroviral therapy (cART). In this paper we review the multiple clinical implications that characterize the multidisciplinary management of HCC in the context of HIV infection...
January 24, 2017: AIDS
https://www.readbyqxmd.com/read/28121710/improved-quality-of-life-with-immediate-initiation-of-antiretroviral-therapy-in-the-strategic-timing-of-antiretroviral-therapy-trial
#5
Alan R Lifson, Birgit Grund, Edward M Gardner, Richard Kaplan, Eileen Denning, Nicole Engen, Catherine L Carey, Fabian Chen, Sounkalo Dao, Eric Florence, Jesus Sanz, Sean Emery
OBJECTIVE: To determine if immediate compared to deferred initiation of antiretroviral therapy (ART) in healthy persons living with HIV (PLWH) had a more favorable impact on health-related quality of life (QOL), or self-assessed physical, mental and overall health status. DESIGN: QOL was measured in START (Strategic Timing of Antiretroviral Therapy), which randomized healthy ART naive PLWH with >500 CD4+ cells/μl from 35 countries to immediate versus deferred ART...
January 24, 2017: AIDS
https://www.readbyqxmd.com/read/28121709/associations-of-the-vaginal-microbiota-with-hiv-infection-bacterial-vaginosis-and-demographic-factors
#6
Christel Chehoud, Daniel J Stieh, Aubrey G Bailey, Alice L Laughlin, Shannon A Allen, Kerrie L McCotter, Scott A Sherrill-Mix, Thomas J Hope, Frederic D Bushman
OBJECTIVE: We sought to investigate the effects of HIV infection on the vaginal microbiota, and associations with treatment and demographic factors. We thus compared vaginal microbiome samples from HIV+ and HIV- women collected at two Chicago area hospitals. DESIGN: We studied vaginal microbiome samples from 178 women analyzed longitudinally (n = 324 samples), and collected extensive data on clinical status and demographic factors. METHODS: We used 16S rRNA gene sequencing to characterize the bacterial lineages present, then UniFrac, Shannon Diversity and other measures to compare community structure to sample metadata...
January 24, 2017: AIDS
https://www.readbyqxmd.com/read/28121708/cerebral-blood-flow-and-cognitive-function-in-hiv-infected-men-with-sustained-suppressed-viremia-on-combination-antiretroviral-therapy
#7
Tanja Su, Henk-Jan Mutsaerts, Matthan W A Caan, Ferdinand W N M Wit, Judith Schouten, Gert J Geurtsen, David J Sharp, Maria Prins, E Richard, Peter Portegies, Peter Reiss, Charles B Majoie
OBJECTIVE: To assess if HIV-infected patients on long-term successful combination antiretroviral therapy (cART) show cerebral blood flow (CBF) alterations in comparison to HIV-uninfected, otherwise similar controls. To explore whether such alterations are associated with HIV-associated cognitive impairment and to explore potential determinants of CBF alterations in HIV. DESIGN: Cross-sectional comparison of CBF in an observational cohort study. METHODS: Clinical, cognitive and magnetic resonance imaging (MRI) data of 100 middle-aged aviremic HIV-infected men on cART and 69 HIV-uninfected controls were collected and compared...
January 24, 2017: AIDS
https://www.readbyqxmd.com/read/28121707/patient-reported-barriers-and-facilitators-to-antiretroviral-adherence-in-sub-saharan-africa-a-systematic-review
#8
Natasha Croome, Monisha Ahluwalia, Lyndsay D Hughes, Melanie Abas
OBJECTIVE: To identify the range and frequency of patient-reported barriers and facilitators to antiretroviral treatment (ART) adherence in Sub-Saharan Africa (SSA). DESIGN: Studies from 2005-2016 were identified by searching 10 electronic databases and through additional hand and web-searching. METHODS: Inclusion criteria were: HIV positive adults taking ART based in any SSA country, qualitative study or quantitative survey and included at least one patient-reported barrier or facilitator to ART adherence...
January 24, 2017: AIDS
https://www.readbyqxmd.com/read/28121706/greater-remnant-lipoprotein-cholesterol-reduction-with-pitavastatin-compared-to-pravastatin-in-hiv-infected-patients-the-intrepid-trial
#9
Parag H Joshi, P Elliott Miller, Seth S Martin, Steven R Jones, Joseph M Massaro, Ralph B D'Agostino, Krishnaji R Kulkarni, Craig Sponseller, Peter P Toth
OBJECTIVE: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in those with HIV. An emerging CVD risk factor is triglyceride-rich remnant lipoprotein cholesterol (RLP-C: the sum of intermediate-density lipoprotein and very low-density lipoprotein3 cholesterol). The effects of statin therapy on lipoprotein subfractions, including RLP-C, in HIV-dyslipidemia are unknown. METHODS: This is a post-hoc analysis of the randomized INTREPID trial (NCT 01301066) comparing pitavastatin 4 mg daily vs...
January 24, 2017: AIDS
https://www.readbyqxmd.com/read/28118207/rectal-microbiota-among-hiv-uninfected-untreated-hiv-and-treated-hiv-infected-men-who-have-sex-with-men-msm-in-nigeria
#10
Rebecca G Nowak, Søren M Bentzen, Jacques Ravel, Trevor A Crowell, Wuese Dauda, Bing Ma, Hongjie Liu, William A Blattner, Stefan D Baral, Manhattan E Charurat
OBJECTIVE: Untreated advanced HIV infection alters the gut microbiota, but it is unclear whether antiretroviral therapy (ART) reverses these changes. We compared the composition of the rectal microbiota among three groups of men who have sex with men (MSM): HIV-uninfected, untreated HIV, and ART-treated HIV-infected. DESIGN: A cross-sectional study was conducted among 130 MSM (55 HIV-uninfected, 41 untreated HIV, 34 ART-treated HIV) in Abuja, Nigeria. METHODS: Bacterial 16S rRNA genes were amplified from rectal swabs, sequenced and clustered into Genera-level operational taxonomic units...
January 21, 2017: AIDS
https://www.readbyqxmd.com/read/28118206/the-gender-gap-a-longitudinal-examination-of-men-s-and-women-s-art-adherence-in-british-columbia-2000-2014
#11
Cathy M Puskas, Angela Kaida, Cari L Miller, Wendy Zhang, Benita Yip, Neora Pick, Julio S G Montaner, Robert S Hogg
OBJECTIVE: The aim of this study was to observe the effect of sex on attaining optimal adherence to combination antiretroviral therapy (cART) longitudinally, while controlling for known adherence confounders: injection drug use (IDU) and ethnicity. DESIGN: Using the population-based HAART Observational Medical Evaluation and Research (HOMER) cohort, data were collected from HIV-positive adults, ≥19 years, receiving cART in British Columbia (BC), Canada, with data collected between 2000 and 2014...
January 21, 2017: AIDS
https://www.readbyqxmd.com/read/28118205/timing-of-cart-initiation-in-male-and-female-migrants-living-with-hiv-in-western-europe-an-observational-cohort-study-1997-2013
#12
(no author information available yet)
BACKGROUND: We evaluate differences in timing of cART (combined Antiretroviral Treatment) initiation by geographical origin in male and female HIV-positive subjects in COHERE, a large European Collaboration of HIV Cohorts. METHODS: We included individuals recruited in Western-Europe between January1997-March2013, with known geographical origin and ≥1CD4 cell count measurement while cART-naïve. Timing of cART was assessed through modified time-to-event methods where a scale of CD4 counts was used instead of time, with cART being the outcome...
January 21, 2017: AIDS
https://www.readbyqxmd.com/read/28107222/romidepsin-induced-hiv-1-viremia-during-effective-art-contains-identical-viral-sequences-with-few-deleterious-mutations
#13
Anni Winckelmann, Kirston Barton, Bonnie Hiener, Timothy E Schlub, Wei Shao, Thomas A Rasmussen, Lars Østergaard, Ole S Søgaard, Martin Tolstrup, Sarah Palmer
OBJECTIVE: To investigate the origin of the HIV-1 viremia induced by the latency-reversing agent romidepsin. DESIGN: Six individuals on suppressive antiretroviral therapy received romidepsin administered intravenously once weekly for three consecutive weeks. CD4+ T-cells were obtained at baseline, following the second and third romidepsin infusion, and 10 weeks after the final romidepsin treatment. METHODS: Single-genome sequencing of the env region was used to genetically characterize the virus from proviral DNA, the transcribed cell-associated RNA and the plasma RNA pool...
January 19, 2017: AIDS
https://www.readbyqxmd.com/read/28107221/cash-vs-food-assistance-to-improve-adherence-to-antiretroviral-therapy-among-hiv-infected-adults-in-tanzania-a-randomized-trial
#14
Sandra I McCoy, Prosper F Njau, Carolyn Fahey, Ntuli Kapologwe, Suneetha Kadiyala, Nicholas P Jewell, William H Dow, Nancy S Padian
OBJECTIVE: We evaluated the effectiveness of short-term cash and food assistance to improve adherence to antiretroviral therapy (ART) and retention in care among people living with HIV in Tanzania. METHODS: At three clinics, 805 participants were randomized to three groups in a 3 : 3 : 1 ratio, stratified by site : nutrition assessment and counseling (NAC) and cash transfers (∼$11/month, n = 347), NAC and food baskets (n = 345), and NAC-only (comparison group, n = 113, clinicaltrials...
January 19, 2017: AIDS
https://www.readbyqxmd.com/read/28099191/long-acting-combination-anti-hiv-drug-suspension-enhances-and-sustains-higher-drug-levels-in-lymph-node-cells-than-in-blood-cells-and-plasma
#15
John C Kraft, Lisa A McConnachie, Josefin Koehn, Loren Kinman, Carol Collins, Danny D Shen, Ann C Collier, Rodney J Y Ho
OBJECTIVE: To determine if a combination of anti-HIV drugs-tenofovir (TFV), lopinavir (LPV), and ritonavir (RTV)-in a lipid-stabilized nanosuspension (called TLC-ART101) could enhance and sustain intracellular drug levels and exposures in lymph node and blood cells above those in plasma. DESIGN: Four macaques were given a single dose of TLC-ART101 subcutaneously. Drug concentrations in plasma and mononuclear cells of the blood (PBMCs) and lymph nodes (LNMCs) were analyzed using a validated combination LC-MS/MS assay...
January 17, 2017: AIDS
https://www.readbyqxmd.com/read/28099190/coagulation-imbalance-and-neurocognitive-functioning-in-older-hiv-adults-on-suppressive-antiretroviral-therapy
#16
Jessica L Montoya, Jennifer Iudicello, Hannah A Oppenheim, Pariya L Fazeli, Michael Potter, Qing Ma, Paul J Mills, Ronald J Ellis, Igor Grant, Scott L Letendre, David J Moore
OBJECTIVES: To compare plasma biomarkers of coagulation between HIV-infected individuals and HIV-uninfected controls and to assess the impact of disturbances in coagulation on neurocognitive functioning in HIV. DESIGN: Cross-sectional study of 66 antiretroviral therapy-treated virally suppressed HIV-infected and 34 HIV-uninfected older (≥50 years of age) adults. METHODS: Participants completed standardized neurobehavioral and neuromedical assessments...
January 17, 2017: AIDS
https://www.readbyqxmd.com/read/28099189/productive-infection-of-human-neural-progenitor-cells-by-r5-tropic-hiv-1-opiate-co-exposure-heightens-infectivity-and-functional-vulnerability
#17
Joyce M Balinang, Ruturaj R Masvekar, Kurt F Hauser, Pamela E Knapp
OBJECTIVE: Human immunodeficiency virus type-1 (HIV-1) causes a spectrum of CNS complications; many are worsened by opiate co-exposure. Human neural progenitor cells (hNPCs) give rise to all CNS neurons and macroglia. We tested the hypothesis that hNPC maturation and fate are altered by HIV and opiates, contributing to HIV-1-related neuropathology. Since reports that hNPCs are infectable remain controversial, we rigorously examined hNPC infection and ability to propagate infection, and determined whether HIV effects on hNPC function required infection...
January 17, 2017: AIDS
https://www.readbyqxmd.com/read/28099188/hepatitis-b-incidence-and-prevention-with-antiretroviral-therapy-among-hiv-positive-individuals-in-rakai-uganda
#18
Emmanuel Seremba, Victor Ssempijja, Sarah Kalibbala, Ronald H Gray, Maria J Wawer, Fred Nalugoda, Corey Casper, Warren T Phipps, Ponsiano Ocama, David Serwadda, David L Thomas, Steven Reynolds
OBJECTIVE: Antiretroviral therapy (ART) may interfere with replication of hepatitis B (HBV) raising the hypothesis that HBV infection might be prevented by ART. We investigated the incidence and risk factors associated with HBV among HIV-infected adults in Rakai, Uganda. METHODS: We screened stored sera from 944 HIV-infected adults enrolled in the Rakai Community Cohort Study between September 2003 and March 2015 for evidence of HBV exposure. Serum from participants who tested anti-HBc negative (497) at baseline were tested over 3-7 consecutive survey rounds for incident HBV...
January 17, 2017: AIDS
https://www.readbyqxmd.com/read/28060020/significant-association-between-statin-associated-myalgia-and-vitamin-d-deficiency-among-treated-hiv-infected-patients
#19
Leonardo Calza, Eleonora Magistrelli, Vincenzo Colangeli, Marco Borderi, Ilaria Contadini, Isabella Bon, Maria Carla Re, Pierluigi Viale
BACKGROUND.: Several studies have shown a significant association between vitamin D deficiency and an increased risk of statin-related symptomatic myalgia in the general population, but there are no data among HIV-infected persons. METHODS.: A retrospective, cohort study was conducted to assess the incidence of symptomatic myalgia and elevation in serum creatine kinase (CK) level among HIV-positive adults on cART and treated with atorvastatin or rosuvastatin for at least 12 months between 2011 and 2015 in our Outpatient Unit...
January 4, 2017: AIDS
https://www.readbyqxmd.com/read/28060019/defining-the-hiv-pre-exposure-prophylaxis-care-continuum
#20
A S Nunn, L Brinkley-Rubinstein, C E Oldenburg, K H Mayer, M Mimiaga, R Patel, P A Chan
No abstract text is available yet for this article.
January 4, 2017: AIDS
journal
journal
20006
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"