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https://www.readbyqxmd.com/read/30608274/increased-il-17-and-or-ifn-%C3%AE-producing-t-cell-subsets-in-gut-mucosa-of-long-term-treated-hiv-1-infected-women
#1
Gabriella D'ettorre, Cristian Borrazzo, Claudia Pinacchio, Letizia Santinelli, Eugenio N Cavallari, Maura Statzu, Gianfranco Fanello, Giancarlo Ceccarelli, Guido Antonelli, Vincenzo Vullo, Claudio M Mastroianni, Carolina Scagnolari
OBJECTIVE: The influence of gender on gut mucosal T cell response in HIV-1 infection remains largely unknown. We explored whether the frequencies of IFN-[Latin Small Letter Gamma] and/or IL-17 producing naïve, central (TCM) and effector (TEM) memory CD4+ (Th1, Th17) and CD8+ T (Tc1, Tc17) cells measured in gut and peripheral districts differed between female and male HIV-1-infected patients. METHODS: Thirty long-term treated HIV-infected individuals were enrolled...
January 2, 2019: AIDS
https://www.readbyqxmd.com/read/30608273/no-effect-of-test-and-treat-on-sexual-behaviours-at-population-level-in-rural-south-africa
#2
Matthieu Rolland, Nuala McGrath, Thierry Tiendrebeogo, Joseph Larmarange, Deenan Pillay, François Dabis, Joanna Orne-Gliemann
CONTEXT: Within the community-randomised ANRS 12249 Treatment-as-Prevention (TasP) trial conducted in rural South Africa, we analysed sexual behaviours stratified by sex over time, comparing immediate ART irrespective of CD4 count vs CD4-guided ART (start at CD4>350 then >500) arms. METHODS: As part of the 6-monthly home-based trial rounds, a sexual behaviour questionnaire (IQ) was administered to all residents ≥16 years. We considered seven indicators: sexual intercourse in the past month; at least one regular sexual partner in the past six months; at least one casual sexual partner in the past six months and more than one sexual partner in the past six months; condom use at last sex (CLS) with regular partner, CLS with casual partner, and point prevalence estimate of concurrency...
January 2, 2019: AIDS
https://www.readbyqxmd.com/read/30608272/hiv-1-detection-in-the-olfactory-mucosa-of-hiv-1-infected-participants
#3
Luca Bertero, Sarah Beth Joseph, Mattia Trunfio, Tiziano Allice, Sebastiano Catera, Daniele Imperiale, Paola Cassoni, Laura Pesci Kincer, Veronica Pirriatore, Valeria Ghisetti, Enrica Amasio, Gianluigi Zanusso, Stefano Bonora, Giovanni Di Perri, Andrea Calcagno
OBJECTIVE: Human Immunodeficiency virus (HIV) infection chronically affects the central nervous system (CNS). Olfactory mucosa (OM) is a unique site in the respiratory tract that is directly connected to the CNS, thus we wanted to evaluate OM as a surrogate of CNS sampling. DESIGN: We conducted a preliminary study examining HIV populations and susceptible cells in the OM. METHODS: OM was sampled by minimally invasive brushing. CSF analyses were performed as per routine clinical procedures...
January 2, 2019: AIDS
https://www.readbyqxmd.com/read/30585848/combination-antibody-treatment-controls-hiv-infection-in-phase-1-trial
#4
Kristin Nicole Harper
No abstract text is available yet for this article.
December 21, 2018: AIDS
https://www.readbyqxmd.com/read/30585847/hiv-associated-cardiovascular-disease-is-global-scourge
#5
Kristin Nicole Harper
No abstract text is available yet for this article.
December 21, 2018: AIDS
https://www.readbyqxmd.com/read/30585846/rapid-art-high-virologic-suppression-rates-with-immediate-art-initiation-in-a-vulnerable-urban-clinic-population
#6
Susa Coffey, Peter Bacchetti, Darpun Sachdev, Oliver Bacon, Diane Jones, Clarissa Opsina-Norvell, Sandra Torres, Elizabeth Lynch, Christy Camp, Remy Mercer-Slomoff, Sulggi Lee, Katerina Christopoulos, Christopher Pilcher, Ling Hsu, Chengshi Jin, Susan Scheer, Diane Havlir, Monica Gandhi
OBJECTIVE: Little is known about long-term viral suppression (VS) rates for patients who start ART soon after diagnosis. We describe virologic outcomes from the San Francisco-based Ward 86 RAPID-ART program. DESIGN: Retrospective review of clinic-based cohort METHODS:: IN 2013, Ward 86 adopted immediate ART at the first visit after HIV diagnosis. Patients were referred from testing sites, offered same-or next-day intakes, and received multidisciplinary evaluation, support, and insurance enrollment/optimization...
December 21, 2018: AIDS
https://www.readbyqxmd.com/read/30585845/hiv-risk-associated-with-serum-medroxyprogesterone-acetate-mpa-levels-among-women-in-east-and-southern-africa-a-case-control-study
#7
Renee Heffron, Randy Stalter, Maria Pyra, Kavita Nanda, David W Erikson, Florian Hladik, Steven W Blue, Nicole L Davis, Nelly Mugo, Athena P Kourtis, Jairam R Lingappa, Jared M Baeten
BACKGROUND: Some observational studies have found increased HIV risk associated with self-reported use of injectable depot medroxyprogesterone acetate (DMPA). Testing blood samples for MPA, the progestin in DMPA, permits validation of self-reported data and exploration of whether potential HIV risk is correlated with MPA levels, which are highest soon after injection. METHODS: We conducted a case-control study testing archived serum from women who participated in three longitudinal studies of HIV prevention in East and southern Africa...
December 21, 2018: AIDS
https://www.readbyqxmd.com/read/30585844/prior-exposure-to-thymidine-analogues-and-didanosine-is-associated-with-long-lasting-alterations-in-adipose-tissue-distribution-and-cardiovascular-risk-factors
#8
Marco Gelpi, Shoaib Afzal, Andreas Fuchs, Jens Lundgren, Andreas D Knudsen, Ninna Drivsholm, Amanda Mocroft, Anne-Mette Lebech, Birgitte Lindegaard, Jørgen T Kühl, Per E Sigvardsen, Lars Køber, Børge G Nordestgaard, Klaus F Kofoed, Susanne D Nielsen
BACKGROUND: Thymidine analogues (TA) and didanosine (ddI) have been associated with redistribution of body fat from subcutaneous (SAT) to visceral (VAT) adipose tissue, which, in turn, is a risk factor for cardiovascular disease (CVD). We explored differences in adipose tissue distribution between people living with HIV (PLWH) with prior exposure to TA and/or ddI, without exposure, and uninfected controls and the association with CVD risk factors. METHODS: 761 PLWH from the COCOMO study and 2,283 age- and sex-matched uninfected controls from the CGPS study were included...
December 21, 2018: AIDS
https://www.readbyqxmd.com/read/30585843/caution-is-needed-in-interpreting-hiv-transmission-chains-by-ultra-deep-sequencing
#9
Eve Todesco, Marc Wirden, Ruxandra Calin, Anne Simon, Sophie Sayon, Francis Barin, Christine Katlama, Vincent Calvez, Anne-Geneviève Marcelin, Stéphane Hué
OBJECTIVES: Molecular epidemiology is applied to various aspects of HIV transmission analyses. With ultra-deep sequencing (UDS), in-depth characterisation of transmission episodes involving minority variants are permitted. We explored HIV-1 epidemiological linkage and evaluated characteristics of transmission dynamics and transmitted drug resistance (TDR) detection through the added value of UDS. DESIGN: HIV pol gene fragments were sequenced by UDS and Sanger sequencing (SS) on samples of 70 HIV-1 infected, treatment-naïve recently diagnosed men having sex with men (MSM)...
December 21, 2018: AIDS
https://www.readbyqxmd.com/read/30585842/reinfection-by-hcv-following-effective-all-oral-daa-therapy-in-hiv-hcv-coinfected-individuals
#10
Juan Berenguer, Ángela Gil-Martin, Inmaculada Jarrin, María L Montes, Lourdes Domínguez, Teresa Aldámiz-Echevarría, María J Téllez, Ignacio Santos, Jesús Troya, Juan E Losa, Regino Serrano, María T De Guzmán, María J Calvo, Juan J González-García
OBJECTIVES: We analyzed HCV reinfection among participants in a prospective registry of HIV/HCV-coinfected patients treated with all-oral DAA-based therapy in the region of Madrid. DESIGN: Observational cohort study. METHODS: The study period started on the date SVR was confirmed. The censoring date was December 31, 2017. SVR was defined as negative HCV-RNA 12 weeks after completion of treatment. Reinfection was defined as a positive HCV-RNA test result after achievement of SVR...
December 21, 2018: AIDS
https://www.readbyqxmd.com/read/30585841/integration-of-care-for-hiv-and-opioid-use-disorder-a-systematic-review-of-interventions-in-clinical-and-community-based-settings
#11
Benjamin J Oldfield, Nicolas Muñoz, Mark P Mcgovern, Melissa Funaro, Merceditas Villanueva, Jeanette M Tetrault, E Jennifer Edelman
OBJECTIVE: We sought to identify optimal strategies for integrating HIV- and opioid use disorder-(OUD) screening and treatment in diverse settings. DESIGN: Systematic review. METHODS: We searched Ovid MEDLINE, PubMed, Embase, and PsycINFO and pre-identified websites. Studies were included if they were published in English on or after 2002 through May 2017, and evaluated interventions that integrated, at an organizational level, screening and/or treatment for HIV and OUD in any care setting in any country...
December 21, 2018: AIDS
https://www.readbyqxmd.com/read/30585840/estimating-national-rates-of-hiv-infection-among-men-who-have-sex-with-men-persons-who-inject-drugs-and-heterosexuals-in-the-united-states
#12
Nicole Crepaz, Kristen L Hess, David W Purcell, H Irene Hall
BACKGROUND: Calculating national rates of HIV diagnosis, incidence, and prevalence can quantify disease burden and is important for planning and evaluating programs. We calculated HIV rates among men who have sex with men (MSM), persons who inject drugs (PWID), and heterosexuals in 2010 and 2015. METHODS: We used proportion estimates of the United States population classified as MSM, PWID, and heterosexuals along with census data to calculate the population sizes which were used as the denominators for calculating HIV rates...
December 21, 2018: AIDS
https://www.readbyqxmd.com/read/30585839/one-step-closer-to-ultra-long-acting-prep
#13
Kristin Nicole Harper
No abstract text is available yet for this article.
December 21, 2018: AIDS
https://www.readbyqxmd.com/read/30601153/associations-between-baseline-biomarkers-and-lung-function-in-hiv-positive-individuals
#14
David M Macdonald, Alexander D Zanotto, Gary Collins, Jason V Baker, Marcin Czarnecki, Eliana Loiza, Daniel E Nixon, Vasileios Papastamopoulos, Chris H Wendt, Robin Wood, Ken M Kunisaki
OBJECTIVE: To analyze the association of baseline biomarker data with cross sectional lung function and subsequent decline in lung function in HIV-positive persons. DESIGN: Lung function was modeled in all START pulmonary substudy participants who had baseline biomarker data and good-quality spirometry. In longitudinal analyses we restricted to those participants with at least one good-quality follow up spirometry test. METHODS: We performed linear regression of baseline FEV1, FVC, and FEV1/FVC and their longitudinal slopes on log2-transformed baseline biomarkers with adjustment for age, sex, race, region, smoking status, baseline CD4+ T-cell counts, and baseline HIV-RNA...
December 19, 2018: AIDS
https://www.readbyqxmd.com/read/30557159/csf-extracellular-vesicles-and-neurofilament-light-protein-as-biomarkers-of-cns-injury-in-hiv-infected-patients-on-antiretroviral-therapy
#15
Debjani Guha, Shibani S Mukerji, Sukrutha Chettimada, Vikas Misra, David R Lorenz, Susan Morgello, Dana Gabuzda
OBJECTIVE: The relationship of cerebrospinal fluid (CSF) extracellular vesicles (EVs) to neurocognitive impairment (NCI) in HIV-infected individuals is unclear. Here, we characterize CSF EVs and their association with CNS injury-related biomarkers (neurofilament light [NFL], S100B, neopterin) and NCI in HIV+ subjects on combination antiretroviral therapy (cART). DESIGN: Cross-sectional and longitudinal study of CSF samples from HIV+ subjects on cART. METHODS: NFL, S100B, and neopterin were measured by ELISA in 190 CSF samples from 112 subjects (67 HIV+ and 45 HIV-)...
December 14, 2018: AIDS
https://www.readbyqxmd.com/read/30557158/sociobehavioral-and-community-predictors-of-unsuppressed-hiv-viral-load-multilevel-results-from-a-hyperendemic-rural-south-african-population
#16
Andrew Tomita, Alain Vandormael, Till Bärnighausen, Andrew Phillips, Deenan Pillay, Tulio De Oliveira, Frank Tanser
OBJECTIVE: Extensive anti-retroviral therapy scale-up is expected to prevent onward transmission of HIV by reducing the overall community viral load (VL). Despite countless studies about predictors of VL derived from clinical settings, to date, no study has established them in sub-Saharan Africa hyperendemic community settings that can inform population-based interventions designed to halt HIV transmission. We used one of Africa's largest population-based prospective cohorts in rural KwaZulu-Natal Province, South Africa, to establish for the first time the socio-demographic, behavioral and community predictors of unsuppressed VL...
December 14, 2018: AIDS
https://www.readbyqxmd.com/read/30570571/the-pharmacokinetics-pharmacodynamics-and-mucosal-responses-to-maraviroc-containing-prep-regimens-in-men-who-have-sex-with-men
#17
Ian McGowan, Timothy Wilkin, Raphael J Landovitz, Chunyuan Wu, Ying Chen, Mark A Marzinke, Craig W Hendrix, Paul Richardson, Susan H Eshleman, Adriana Andrade, Wairimu Chege, Peter L Anderson, Marybeth McCauley, Jason Farley, Kenneth H Mayer, Peter Anton, Rhonda M Brand, Ross D Cranston, Roy Gulick
OBJECTIVE: HIV Prevention Trials Network 069/AIDS Clinical Trials Group A5305 was a study of 48-week oral pre-exposure prophylaxis (PrEP) regimens in MSM and transgender women. A rectal substudy was included to evaluate drug concentrations in rectal compartment vs. blood, gut-associated lymphoid tissue (GALT) responses to four antiretroviral PrEP regimens [maraviroc (MVC), MVC + emtricitabine (FTC), MVC + tenofovir (TFV) disoproxil fumarate, and TFV disoproxil fumarate + FTC], and to determine whether ARV exposure was associated with ex-vivo suppression of HIV infection in colorectal explants...
December 13, 2018: AIDS
https://www.readbyqxmd.com/read/30557161/towards-unaids-fast-track-goals-targeting-priority-geographic-areas-for-hiv-prevention-and-care-in-zimbabwe
#18
Diego F Cuadros, Jingjing Li, Zindoga Mukandavire, Godfrey N Musuka, Adam J Branscum, Benn Sartorius, Owen Mugurungi, Frank Tanser
INTRODUCTION: Zimbabwe has made substantial progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) targets of 90-90-90 by 2020, with 73% of people living with HIV diagnosed, 87% of those diagnosed on antiretroviral therapy (ART), and 86% of those on ART virally suppressed. Despite this exceptional response, more effort is needed to completely achieve the UNAIDS targets. Here, we conducted a detailed spatial analysis of the geographical structure of the HIV epidemic in Zimbabwe to include geographical prioritization as a key component of their overall HIV intervention strategy...
December 13, 2018: AIDS
https://www.readbyqxmd.com/read/30531399/the-multidimensionality-of-masculine-norms-in-east-zimbabwe-implications-for-hiv-prevention-testing-and-treatment
#19
Rebecca Rhead, Morten Skovdal, Albert Takaruza, Rufurwokuda Maswera, Constance Nyamukapa, Simon Gregson
BACKGROUND: Research and intervention studies suggest that men face challenges in using HIV services in sub-Saharan Africa. To address these challenges, quantitative measurements are needed to establish the individual-level determinants of masculine norms and their implications for HIV prevention and treatment programmes. METHODS: Survey questions for four masculine norms identified in qualitative research were included in a general-population survey of 3116 men in east Zimbabwe, 2012-2013...
December 10, 2018: AIDS
https://www.readbyqxmd.com/read/30531320/postpartum-hiv-care-continuum-outcomes-in-the-southeastern-us
#20
Jane S Chen, Brian W Pence, Lisa Rahangdale, Kristine B Patterson, Claire E Farel, Amy L Durr, Amanda C Antono, Oksana Zakharova, Joseph J Eron, Sonia Napravnik
OBJECTIVE: Evaluate postpartum HIV care outcomes. DESIGN: Prospective clinical cohort of women with HIV and a live birth at the University of North Carolina, 1996-2014. METHODS: We estimated two stages of the HIV care continuum in the first 24 months postpartum: care retention (≥2 visits per year, ≥90 days apart) and viral suppression (HIV RNA < 400 copies/mL). Multivariable models were fit using logistic regression. RESULTS: Among 1416 women, 141 experienced a live birth at a median age of 28 years, with 74% virally suppressed at delivery...
November 27, 2018: AIDS
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