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https://www.readbyqxmd.com/read/28806198/pre-treatment-integrase-strand-transfer-inhibitor-resistance-in-north-carolina-from-2010-2016
#1
Timothy W Menza, Rachael Billock, Erika Samoff, Joseph J Eron, Ann M Dennis
OBJECTIVE: We sought to define the prevalence of pre-treatment INSTI resistance and assess the transmission networks of those with pre-treatment INSTI resistance. DESIGN: A retrospective cohort study of HIV-positive patients with genotypic resistance testing sent to a single referral laboratory in North Carolina between 2010 and 2016. METHODS: We linked genotype and public health data for in-care HIV-positive individuals to determine the prevalence of INSTI resistance among treatment-naïve (defined as those with a first genotype ≤3 months after diagnosis) and treatment-experienced (defined as those with a first genotype >3 months after diagnosis) patients...
August 12, 2017: AIDS
https://www.readbyqxmd.com/read/28806197/frailty-is-strongly-associated-with-increased-risk-of-recurrent-falls-among-older-hiv-infected-adults-a-prospective-cohort-study
#2
Katherine Tassiopoulos, Mona Abdo, Kunling Wu, Susan L Koletar, Frank J Palella, Robert Kalayjian, Babafemi Taiwo, Kristine M Erlandson
OBJECTIVE: Both frailty and falls occur at earlier than expected ages among HIV-infected individuals, but the contribution of frailty to fall risk in this population is not well understood. We examined this association among participants enrolled in AIDS Clinical Trials Group (ACTG) A5322. DESIGN: A prospective, multi-center cohort study of HIV-infected men and women ≥40 years. METHODS: Frailty assessment included a 4-meter walk, grip strength, and self-reported weight loss, exhaustion, and low physical activity...
August 12, 2017: AIDS
https://www.readbyqxmd.com/read/28806196/the-costs-of-hiv-treatment-and-care-in-ghana-a-longitudinal-multi-site-analysis
#3
Evelinn Mikkelsen, Jan Hontelez, Justice Nonvignon, Sam Amon, Felix A Asante, Moses K Aikins, Julie van de Haterd, Rob Baltussen
OBJECTIVE: To determine cost-functions that describe the dynamics of costs of HIV treatment and care in Ghana by CD4 cell count at treatment initiation and over time on antiretroviral therapy (ART). DESIGN: We used detailed longitudinal healthcare utilization data from clinical health records of HIV-infected patients at seven Ghanaian ART clinics to estimate cost-functions of treatment and care by CD4 cell count at treatment initiation and time on ART. METHODS: We developed two linear regression models; one with individual random effects to determine the relationship between CD4 cell count at ART initiation and costs of treatment and care, and one with individual fixed effects to determine the causal effect of time in care on costs of treatment and care...
August 12, 2017: AIDS
https://www.readbyqxmd.com/read/28806195/antiretroviral-combination-use-during-pregnancy-and-the-risk-of-major-congenital-malformations
#4
Anick Bérard, Odile Sheehy, Jin-Ping Zhao, Michal Abrahamowicz, Mona Loutfy, Isabelle Boucoiran, Sasha Bernatsky
OBJECTIVE: To quantify the risk of major congenital malformations associated with gestational combination antiretroviral use. DESIGN: Population-based prospective cohort study. METHODS: Using the Quebec Pregnancy Cohort from 1998-2015, we included women who covered by Quebec Drug Plan and have a singleton livebirth. All antiretroviral use alone or in combination were considered. Major congenital malformations overall and organ-specific malformations in the first year of life were identified...
August 12, 2017: AIDS
https://www.readbyqxmd.com/read/28742529/risk-factors-for-early-mortality-on-antiretroviral-therapy-in-advanced-hiv-infected-adults
#5
Gregory P Bisson, Ritesh Ramchandani, Sachiko Miyahara, Rosie Mngqibisa, Mitch Matoga, McNeil Ngongondo, Wadzanai Samaneka, Lucy Koech, Kogieleum Naidoo, Mohammed Rassool, Fredrick Kirui, Peter Banda, Vidya Mave, Dileep Kadam, Paul Leger, German Henostroza, Yukari C Manabe, Jing Bao, Johnstone Kumwenda, Amita Gupta, Mina C Hosseinipour
BACKGROUND: Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but risk factors for death in these patients are unclear. METHODS: We used data from a multi-site randomized trial comparing empiric versus preventive TB therapy in HIV-infected adults initiating ART with CD4 counts <50 cells/mm to evaluate risk factors for death within 48 weeks after ART initiation...
July 24, 2017: AIDS
https://www.readbyqxmd.com/read/28723712/the-role-of-oncogenic-hpv-determination-for-diagnosis-of-high-grade-anal-intraepithelial-neoplasia-in-hiv-infected-msm
#6
Joaquin Burgos, J Hernández-Losa, S Landolfi, A Guelar, Mªc Dinares, J Villar, J Navarro, E Ribera, V Falcó, A Curran
OBJECTIVE: To assess the oncogenic human papillomavirus (HPV) determination and the co-testing HPV and anal cytology value to detect high-grade anal intraepithelial neoplasia (HGAIN) in a cohort of HIV-MSM. DESIGN AND METHODS: Prospective study of HIV-infected MSM who underwent screening for anal dysplasia. Screening program includes anal cytology, HPV testing, and high-resolution anoscopy (HRA) at each visit. Histological samples were obtained if suspicious lesions were revealed by HRA...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28723711/epidemiology-of-autoimmune-and-inflammatory-diseases-in-a-french-nationwide-hiv-cohort
#7
D Lebrun, M Hentzien, L Cuzin, D Rey, V Joly, L Cotte, C Allavena, P Dellamonica, A Servettaz, F Bani-Sadr
HIV infection and inflammatory and autoimmune diseases (IAD) are both related to immune dysfunction. Epidemiological data on IAD in patients living with HIV (PLHIV) are scarce. The aim of this study was thus to estimate the prevalence of 26 IAD among PLHIV followed in a large French multicenter cohort in the cART era (from January 2000 to July 2013), and to describe their occurrence according to cART onset, the immuno-virological status of patients and HCV and/or HBV co-infection.During the study period, 33 403 PLHIV were included in the Dat'AIDS cohort; 1381 patients with an IAD were identified...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28723710/controlled-attenuation-parameter-and-mr-spectroscopy-measured-liver-steatosis-are-discordant-in-hiv-infected-adults-with-high-body-mass
#8
Jennifer C Price, Jennifer L Dodge, Yifei Ma, Rebecca Scherzer, Natalie Korn, Kyle Tillinghast, Marion G Peters, Susan Noworolski, Phyllis C Tien
OBJECTIVE: Hepatic steatosis (HS) is common in HIV-infected individuals. Magnetic resonance spectroscopy (MRS) is the preferred non-invasive method for HS measurement but is expensive. Controlled attenuation parameter (CAP) also assesses HS and is conveniently performed concomitantly with transient elastography. We aimed to assess the accuracy of CAP in the setting of HIV infection. DESIGN: Cross-sectional study. METHODS: CAP and MRS were performed in 82 subjects (39 HIV-monoinfected;7 HCV-monoinfected;21 HIV/HCV-coinfected; 15 with neither infection)...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28723709/delivering-prep-to-pregnant-and-breastfeeding-women-in-sub-saharan-africa-the-implementation-science-frontier
#9
Dvora L Joseph Davey, Linda-Gail Bekker, Pamina Gorbach, Thomas Coates, Landon Myer
: HIV acquisition during pregnancy and postpartum periods remains high despite increased access to and initiation of antiretroviral therapy in sub-Saharan Africa. Moreover, maternal seroconversion during pregnancy and breastfeeding remains a source of significant paediatric HIV infection in the region. In order to curb vertical HIV transmission, HIV acquisition during pregnancy and lactation must significantly decline. Biological and behavioural factors contribute to high HIV incidence, including hormonal changes that alter genital mucosal surfaces, and frequent condomless sex with HIV-infected partners or partners of unknown serostatus...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28723708/subclinical-herpesvirus-shedding-among-hiv-1-infected-men-on-antiretroviral-therapy
#10
Arcadio Agudelo-Hernandez, Yue Chen, Arlene Bullotta, William G Buchanan, Cynthia R Klamar-Blain, Luann Borowski, Sharon A Riddler, Charles R Rinaldo, Bernard Jc Macatangay
DESIGN: We evaluated the subclinical shedding of 6 different herpesviruses in antiretroviral drug-treated HIV(+) men who have sex with men (MSM), and determined how this is associated with markers of inflammation and immune activation. METHODS: We obtained blood, semen, throat washing, urine, and stool from 15 antiretroviral-treated HIV-1-infected MSM with CD4 T cell reconstitution, and 12 age-matched HIV(-) MSM from the Multicenter AIDS Cohort Study at 4 timepoints over 24 weeks to measure DNA levels of cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus 1 and 2, human herpesvirus 6 (HHV6), and HHV8...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28723707/towards-standardised-definitions-for-monitoring-the-continuum-of-hiv-care-in-europe
#11
Annabelle J Gourlay, Anastasia M Pharris, Teymur Noori, Virginie Supervie, Magdalena Rosinska, Ard van Sighem, Giota Touloumi, Kholoud Porter
No abstract text is available yet for this article.
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28723706/oral-shedding-of-herpesviruses-in-hiv-patients-with-varying-degrees-of-immune-status
#12
Dirk P Dittmer, Kristen Tamburro, Huichao Chen, Anthony Lee, Marcia K Sanders, Tischan A Wade, Sonia Napravnik, Jennifer Webster-Cyriaque, Mahmoud Ghannoum, Caroline H Shiboski, Judith A Aberg
OBJECTIVE: Herpesvirus shedding in the oral cavity was analyzed to determine if presence in the oral compartment correlates with systemic changes in HIV-associated immune deficiency as measured by CD4+ counts, plasma HIV viral load (VL) and presence of AIDS-defining events. DESIGN: A5254 is a multicenter, cross-sectional, single-visit study to evaluate oral complications of HIV/AIDS and determine the association between clinical appearance, herpesvirus shedding and immune status as ascertained by CD4 count and HIV viral load...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28692547/seroprevalence-of-hepatitis-e-virus-in-hiv-infected-patients-in-china
#13
Hang Zeng, Lin Wang, Peng Liu, Lingjie Liao, Ling Wang, Yiming Shao
: The seroprevalence of hepatitis E virus (HEV) in HIV-infected patients in China has never been reported. Thus, anti-HEV in HIV-infected patients recruited in five provinces in China was tested. The seroprevalence of HEV was 39.7%, which was higher than that in the general population (23.5%). HEV infection might be a frequent cause of hepatitis in HIV-infected patients.
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692546/hhv8-and-kaposi-s-sarcoma-should-we-really-give-up-protease-inhibitors-in-all-hiv-infected-patients
#14
Patrick Philibert, Laurent Chiche, Sylvie Caillères, Julie Allemand, Stanislas Rebaudet, Marion Delord, Chloé Stavris, Frédérique Retornaz, Hacène Khiri, Philippe Halfon
We describe the first case of a patient presenting Kaposi's Sarcoma with HHV8 viremia after switching from a protease inhibitor (PI) to an integrase inhibitor-based combination antiretroviral therapy, followed by a rapid remission when resuming PI. We suggest that the recent recommendations to switch all HIV patients to PI-free regimens should be carefully reevaluated especially in men who have sex with men HIV patients which are at higher risks of HHV8 infections and associated malignancies.
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692545/selection-of-women-at-risk-for-cervical-cancer-in-an-hiv-infected-south-african-population
#15
Marjolein Van Zummeren, Wieke W Kremer, Matthys C Van Aardt, Erika Breytenbach, Karin L Richter, Lawrence Rozendaal, Birgit I Witte, Lise M A de Strooper, Albertus T Hesselink, Daniëlle A M Heideman, Peter J F Snijders, Renske D M Steenbergen, Greta Dreyer, Chris J L M Meijer
OBJECTIVE: Cervical cancer is the leading cause of cancer-related death in women in South Africa. This study evaluates DNA methylation levels in cervical (pre)cancer and aims to assess the value of high-risk human papillomavirus (hrHPV) testing and methylation analysis, alone or in combination, on physician-taken cervical scrapes to detect cervical cancer, and cervical intraepithelial neoplasia grade 3 (CIN3) in an HIV-infected South African population. DESIGN: Prospective observational multi-centre cohort study...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692544/the-effect-of-school-attendance-and-school-dropout-on-incident-hiv-and-hsv-2-among-young-women-in-rural-south-africa-enrolled-in-hptn-068
#16
Marie C D Stoner, Audrey Pettifor, Jessie K Edwards, Allison E Aiello, Carolyn T Halpern, Aimée Julien, Amanda Selin, Rhian Twine, James P Hughes, Jing Wang, Yaw Agyei, F Xavier Gomez-Olive, Ryan G Wagner, Catherine Macphail, Kathleen Kahn
OBJECTIVE: To estimate the association between school attendance, school dropout, and risk of incident HIV and HSV-2 infection among young women. DESIGN: We used longitudinal data from a randomized controlled trial in rural Mpumalanga province, South Africa, to assess the association between school days attended, school dropout and incident HIV and HSV-2 in young women aged 13-23 years. METHODS: We examined inverse probability of exposure weighted survival curves and used them to calculate 1...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692543/impact-and-economic-evaluation-of-a-novel-hiv-service-delivery-model-in-rural-malawi
#17
Ryan K McBain, Elizabeth Petersen, Nora Tophof, Elizabeth Dunbar, Noel Kalanga, Lawrence Nazimera, Andrew Mganga, Luckson Dullie, Joia Mukherjee, Emily B Wroe
OBJECTIVE: We performed an impact and cost-effectiveness analysis of a novel HIV service delivery model in a high prevalence, remote district of Malawi with a population of 143,800 people. DESIGN: A population-based retrospective analysis of one-year survival rates among newly-enrolled HIV+ patients at 682 health facilities throughout Malawi, comparing facilities implementing the service delivery model (n = 13) and those implementing care-as-usual (n = 669)...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692542/the-effect-of-oral-pre-exposure-prophylaxis-on-the-progression-of-hiv-1-seroconversion
#18
Deborah Donnell, Eric Ramos, Connie Celum, Jared Baeten, Joan Dragavon, Jordan Tappero, Jairam R Lingappa, Allan Ronald, Kenneth Fife, Robert W Coombs
OBJECTIVE: To investigate whether oral pre-exposure prophylaxis (PrEP) alters timing and patterns of seroconversion when PrEP use continues after HIV-1 infection. DESIGN: Retrospective testing of the timing of Fiebig stage HIV-1 seroconversion in the Partners PrEP Study, a randomized placebo-controlled clinical trial of PrEP conducted in Kenya and Uganda. METHODS: Specimens from 138 seroconverters were collected every 3 months and when HIV-1 infection was suspected based on monthly rapid HIV-1 tests...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692541/the-value-of-point-of-care-cd4-and-laboratory-viral-load-in-tailoring-art-monitoring-strategies-to-resource-limitations
#19
Emily P Hyle, Ilesh V Jani, Katherine L Rosettie, Robin Wood, Benjamin Osher, Stephen Resch, Pamela P Pei, Paolo Maggiore, Kenneth A Freedberg, Trevor Peter, Robert A Parker, Rochelle P Walensky
OBJECTIVE: To examine the clinical and economic value of point-of-care CD4 (POC-CD4) or viral load (VL) monitoring compared to current practices in Mozambique, a country representative of the diverse resource limitations encountered by HIV treatment programs in sub-Saharan Africa. DESIGN/METHODS: We use the CEPAC-I model to examine the clinical impact, cost (2014 US$), and incremental cost-effectiveness ratio (ICER, $/year of life saved [YLS]) of ART monitoring strategies in Mozambique...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28692540/unique-microrna-expression-in-the-colonic-mucosa-during-chronic-hiv-1-infection
#20
Jennifer A Fulcher, Georgios Koukos, Marina Koutsioumpa, Julie Elliott, Alexandra Drakaki, Dimitrios Iliopoulos, Peter A Anton
OBJECTIVE: Chronic HIV-1 infection leads to widespread inflammation and immune dysregulation. The gastrointestinal mucosa, a primary site for HIV-1 replication, is thought to play a significant role in this response. MicroRNAs (miRs) are small non-coding RNAs that regulate gene expression, including immune activation and inflammation. Here we investigate miR expression and function in the colonic mucosa during HIV-1 infection. DESIGN AND METHODS: Using miR profiling, we examined miR expression in the colonic mucosa of HIV-infected subjects...
July 7, 2017: AIDS
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