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Acta Tropica

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https://www.readbyqxmd.com/read/29050950/modeling-and-comparative-study-of-the-spread-of-zoonotic-visceral-leishmaniasis-from-northern-to-central-tunisia
#1
Belhassen Kaab, Elyes Zhioua
During the last twenty years, zoonotic visceral leishmaniasis (ZVL) spread from the north characterized by humid, sub-humid, and semi-arid bio-climates to the arid areas located in Central Tunisia. In order to understand the eco-epidemiological factors involved in the distribution of ZVL, both a sero-epidemiological and an entomological investigation were performed in two governorates situated in two different bio-geographical areas: Bizerte in the north and Kairouan in the center. A mathematical model for transmission of ZVL was built, describing the disease dynamic in these areas...
October 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29050949/high-frequency-of-trypanosomatids-in-gallery-forest-bats-of-a-neotropical-savanna
#2
João Lucas M Lourenço, Thaís T C Minuzzi-Souza, Larissa R Silva, Amanda C Oliveira, Vagner J Mendonça, Nadjar Nitz, Ludmilla M S Aguiar, Rodrigo Gurgel-Gonçalves
Bats are well-known hosts of trypanosomatids, though information about their role as reservoirs of these protozoans in the Brazilian savanna is poorly known. We aimed to analyze the occurrence of trypanosomatid species in bats occurring in remnants of gallery forests of Brasília, Federal District of Brazil. We sampled bats using mist nets in six sites, and we collected blood, wing fragments and oral swab samples from all captured individuals. Trypanosomatids were identified in the captured bats through sequencing of the SSUrRNA region and kDNA qPCR...
October 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29042262/molecular-epidemiology-and-in-vitro-evidence-suggest-that-leishmania-braziliensis-strain-helps-determine-antimony-response-among-american-tegumenary-leishmaniasis-patients
#3
Silvana C Silva, Luiz Henrique Guimarães, Juliana A Silva, Viviane Magalhães, Lilian Medina, Adriano Queiroz, Paulo Roberto L Machado, Albert Schriefer
Antimony is the first line drug for treating American tegumentary leishmaniasis (ATL) in Brazil. In this country, Leishmania braziliensis causes at least three distinct forms of disease: localized cutaneous (CL), mucosal (ML) and disseminated leishmaniasis (DL). All forms can be found in Corte de Pedra, Northeast Brazil. ML and DL respond poorly to antimony, in contrast to CL. The L. braziliensis population causing ATL in Corte de Pedra is genetically very diverse, with strains of the parasite associating with the clinical form of leishmaniasis...
October 14, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29042261/biology-of-the-introduced-species-triatoma-lecticularia-hemiptera-reduviidae-to-northwestern-mexico-under-laboratory-conditions
#4
Yunuen Grant-Guillén, Benjamín Nogueda-Torres, Jordi Gascón-Sánchez, Gumercindo Goicochea-Del Rosal, José Alejandro Martínez-Ibarra
The first record of Triatoma lecticularia out of its reported distribution area together with the brief description of the said area is provided in this paper. In addition, some biological parameters related to hatching of eggs, life cycle and feeding and defecation behaviors for each instar of one population of T. lecticularia from its previously reported distribution area (PR) and for each instar of that introduced recently found population (IS) of this species were evaluated and compared. Twenty-eight specimens were collected from IS, mostly (64...
October 14, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29037520/immunization-with-ljm11-salivary-protein-protects-against-infection-with-leishmania-braziliensis-in-the-presence-of-lutzomyia-longipalpis-saliva
#5
Jurema M Cunha, Melissa Abbehusen, Martha Suarez, Jesus Valenzuela, Clarissa R Teixeira, Cláudia I Brodskyn
Leishmania is transmitted in the presence of sand fly saliva. Protective immunity generated by saliva has encouraged identification of a vector salivary-based vaccine. Previous studies have shown that immunization with LJM11, a salivary protein from Lutzomyia longipalpis, is able to induce a Th1 immune response and protect mice against bites of Leishmania major-infected Lutzomyia longipalpis. Here, we further investigate if immunization with LJM11 recombinant protein is able to confer cross-protection against infection with Leishmania braziliensis associated with salivary gland sonicate (SGS) from Lutzomyia intermedia or Lu...
October 13, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29037519/the-akt-like-kinase-of-leishmania-panamensis-as-a-new-molecular-target-for-drug-discovery
#6
Didier Tirado-Duarte, Marcel Marín-Villa, Rodrigo Ochoa, Gustavo Blandón-Fuentes, Maurilio José Soares, Sara Maria Robledo, Rubén E Varela-Miranda
The Akt-like kinase of Leishmania spp. is a cytoplasmic orthologous protein of the serine/threonine kinase B-PKB/human-Akt group, which is involved in the cellular survival of these parasites. By the application of a computational strategy we obtained two specific inhibitors of the Akt-like protein of L. panamensis (UBMC1 and UBMC4), which are predicted to bind specifically to the pleckstrin domain (PH) of the enzyme. We show that the Akt-like of Leishmania panamensis is phospho-activated in parasites under nutritional and thermic stress, this phosphorylation is blocked by the UBMC1 and UMBC2 and such inhibition leads to cell death...
October 13, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29030043/quality-of-anthelminthic-medicines-available-in-jimma-ethiopia
#7
Sileshi Belew, Sultan Suleman, Evelien Wynendaele, Matthias D'Hondt, Anne Kosgei, Luc Duchateau, Bart De Spiegeleer
Soil-transmitted helminthiasis and schistosomiasis are major public health problems in Ethiopia. Mass deworming of at-risk population using a single dose administration of 400mg albendazole (ABZ) or 500mg mebendazole (MBZ) for treatment of common intestinal worms and 40mg of praziquantel (PZQ) per kg body weight for treatment of schistosomiasis is one of the strategies recommended by World Health Organization (WHO) in order to control the morbidity of soil-transmitted helminthiasis and schistosomiasis. Since storage condition, climate, way of transportation and distribution route could all affect the quality of medicines, regular assessment by surveys is very critical to ensure the therapeutic outcome, to minimize risk of toxicity to the patient and resistance of parasites...
October 13, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29030042/genetic-variability-and-transcontinental-sharing-of-giardia-duodenalis-infrapopulations-determined-by-glutamate-dehydrogenase-gene
#8
Adel Spotin, Majid Karamat, Mahmoud Mahami-Oskouei, Abbas Shahbazi, Ehsan Ahmadpour, Tahereh Mikaeili Galeh, Shirzad Fallahi
Microevolutionary data of Giardia duodenalis sub-assemblages is a prerequisite for determining the invasion zoonotic patterns of the parasite. To infer transmission patterns that could not be differentiated by the phenotypic features, a population genetic investigation is crucial for the elucidation of the genetic structure of G. duodenalis among the continents. Forty G. duodenalis positive fecal samples were collected from different foci of Northwest Iran. The specimens were subjected to Trichrome staining and sucrose gradient flotation...
October 13, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29024616/investigation-of-infectious-reproductive-pathogens-of-large-ruminants-are-neosporosis-brucellosis-leptospirosis-and-bvdv-of-relevance-in-lao-pdr
#9
L Olmo, M T Dye, M P Reichel, J R Young, S Nampanya, S Khounsy, P C Thomson, P A Windsor, R D Bush
N. caninum, bovine viral diarrhoea virus, Brucella abortus and Leptospira interrogans serovar Hardjo are globally significant reproductive pathogens that cause abortion and reproductive loss in large ruminants. Prevalence information is lacking in Lao People's Democratic Republic (Laos) despite the poor reproductive performance of cattle and buffalo. Serological examination of frozen cattle (n=90) and buffalo (n=61) sera by commercially available enzyme-linked immunosorbent assays provided the first reported screening of some of these pathogens in Laos...
October 9, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29024615/molecular-confirmation-of-hepatozoon-canis-in-mauritius
#10
Aikaterini Alexandra Daskalaki, Angela Monica Ionică, Keshav Jeetah, Călin Mircea Gherman, Andrei Daniel Mihalca
In this study, Hepatozoon species was molecularly identified and characterized for the first time on the Indian Ocean island of Mauritius. Partial sequences of the 18S rRNA gene of the Hepatozoon isolates were analysed from three naturally infected dogs. The sequences of H. canis were similar to the 18S rRNA partial sequences (JX112783, AB365071 99%) from dog blood samples from West Indies and Nigeria. Our sequences were deposited in the GenBank database.
October 9, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29017878/andean-cutaneous-leishmaniasis-andean-cl-uta-in-peru-and-ecuador-the-causative-leishmania-parasites-and-clinico-epidemiological-features
#11
REVIEW
Yoshihisa Hashiguchi, Eduardo A L Gomez, Abraham G Cáceres, Lenin N Velez, Nancy V Villegas, Kazue Hashiguchi, Tatsuyuki Mimori, Hiroshi Uezato, Hirotomo Kato
This study provides comprehensive information on the past and current status of the Andean cutaneous leishmaniasis (Andean-CL, uta) in Peru and Ecuador, mainly focusing on the causative Leishmania parasites and clinico-epidemiological features. Available information and data including our unpublished works were analyzed thoroughly. Endemic regions of the Andean-CL (uta) in Peru run from the north Piura/Cajamarca to the south Ayacucho at a wide range of the Pacific watersheds of the Andes through several departments, while in Ecuador those exist at limited and spotted areas in the country's mid-southwestern two provinces, Azuay and Chimborazo...
October 7, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29017877/therapeutic-efficacy-of-artesunate-amiodaquine-for-treating-uncomplicated-falciparum-malaria-at-ghindae-zonal-referral-hospital-eritrea
#12
Abdu O Mohammed, Seltene Tewolde, Dawit Estifanos, Yohannes Tekeste, Mohammed-Hamid Osman
INTRODUCTION: The aim of this study was to assess the efficacy of artesunate-amodiaquine (AS+AQ) which is the first-line treatment for uncomplicated falciparum malaria in Eritrea. MATERIALS AND METHODS: The study was conducted from December 2014 to March 2015 in Ghindae Zonal Referral Hospital in Northern Red Sea Zone. Out of 481 patients screened, 103 were enrolled in the study. The therapeutic efficacy test was done as per the WHO protocol for a period of 28days of follow-up...
October 7, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29017876/animal-and-human-tungiasis-related-knowledge-and-treatment-practices-among-animal-keeping-households-in-bugiri-district-south-eastern-uganda
#13
Francis Mutebi, Jürgen Krücken, Georg von Samson-Himmelstjerna, Charles Waiswa, Norbert Mencke, Wilfred Eneku, Tamale Andrew, Hermann Feldmeier
BACKGROUND: Zoonotic tungiasis caused by Tunga penetrans remains a serious public and animal health problem among endemic villages in Uganda and many sub Saharan African countries. Studies on human and animal tungiasis-related knowledge and treatment practices in endemic communities have never been undertaken, a limitation to development of sustainable control measures. METHODS: A cross sectional study using semi-structured questionnaires (Supplementary file S1) was conducted among 236 animal rearing households in 10 endemic villages in Bugiri District, South-Eastern Uganda...
October 7, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29017875/hierarchical-dynamics-influence-the-distribution-of-immature-black-flies-diptera-simuliidae
#14
Anbalagan Sankarappan, Kannan Mani, Dinakaran Sundaram, Balasubramanian Chelliah, Krishnan Muthukalingan
Adult black flies (Simuliidae) are medically important insects and they are the sole vector of Onchocerca volvulus. Immature black flies are major components of aquatic macroinvertebrate assemblages in streams and play a vital role in nutrient dynamics. In this study, we examined effect of hierarchical dynamics (spatio-temporal pattern) on the distribution of immature black flies in South Indian streams. The sampling was done in streams of Western Ghats, South India. A total of 16 species belong to two subgenera: Simulium (10 species) and Gowmphostilbia (6 species) of Simulium were observed...
October 7, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28993182/spatial-and-temporal-distribution-of-pfmsp1-and-pfmsp2-alleles-and-genetic-profile-change-of-plasmodium-falciparum-populations-in-gabon
#15
J M NdongNgomo, N P M'Boundoukwé, W Yavo, L C Bongho Mavoungou, M K Bouyou-Akotet, D P Mawili-Mboumba
Plasmodium population dynamics analysis may help to assess the impact of malaria control strategies deployment. In Gabon, new strategies have been introduced, but malaria is still a public health problem marked by a rebound of the prevalence in 2011. The aim of the study was to investigate the spatial and temporal distribution of P. falciparum strains in different areas in Gabon during a period of malaria transmission transition, between 2008 and 2011. A total of 109P. falciparum isolates were genotyped using nested-PCR of Pfmsp1 and Pfmsp2 genes...
October 6, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28986249/presence-of-borrelia-spp-dna-in-ticks-but-absence-of-borrelia-spp-and-of-leptospira-spp-dna-in-blood-of-fever-patients-in-madagascar
#16
Ralf Matthias Hagen, Hagen Frickmann, Julian Ehlers, Andreas Krüger, Gabriele Margos, Cecilia Hizo-Teufel, Volker Fingerle, Raphael Rakotozandrindrainy, Vera von Kalckreuth, Justin Im, Gi Deok Pak, Hyon Jin Jeon, Jean Philibert Rakotondrainiarivelo, Jean Noël Heriniaina, Tsiry Razafindrabe, Frank Konings, Jürgen May, Benedikt Hogan, Jörg Ganzhorn, Ursula Panzner, Norbert Georg Schwarz, Denise Dekker, Florian Marks, Sven Poppert
The occurrence of tick-borne relapsing fever and leptospirosis in humans in Madagascar remains unclear despite the presence of their potential vectors and reservoir hosts. We screened 255 Amblyomma variegatum ticks and 148 Rhipicephalus microplus ticks from Zebu cattle in Madagascar for Borrelia-specific DNA. Borrelia spp. DNA was detected in 21 Amblyomma variegatum ticks and 2 Rhipicephalus microplus ticks. One Borrelia found in one Rhipicephalus microplus showed close relationship to Borrelia theileri based on genetic distance and phylogenetic analyses on 16S rRNA and flaB sequences...
October 3, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28986248/the-roles-of-galectins-in-parasitic-infections
#17
REVIEW
Weikun Shi, Chunyu Xue, Xin-Zhuan Su, Fangli Lu
Galectins is a family of multifunctional lectins. Fifteen galectins have been identified from a variety of cells and tissues of vertebrates and invertebrates. Galectins have been shown to play pivotal roles in host-pathogen interaction such as adhesion of pathogens to host cells and activation of host innate and adaptive immunity. In recent years, the roles of galectins during parasite infections have gained increasing attention. Galectins produced by different hosts can act as pattern recognition receptors (PRR) detecting conserved pathogen-associated molecular patterns (PAMPs) of parasites, while galectins produced by parasites can modulate host responses...
October 3, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28986247/the-reintroduction-of-denv-2-in-2011-in-panama-and-subsequent-outbreak-characteristic
#18
Yamilka Díaz, Julio Cisneros, Hilda Guzmán, Paola Cordoba, Jean-Paul Carrera, Brechla Moreno, Rubing Chen, Juan Castillo Mewa, Lourdes García, Lizbeth Cerezo, Amelia Travassos da Rosa, Nathan D Gundacker, Blas Armién, Scott C Weaver, Nikos Vasilakis, Sandra López-Vergès, Robert Tesh
The circulation of the South-east Asian/American (AS/AM) dengue 2 virus (DENV-2) genotype in the Americas has been associated with a high rate of severe disease. From 1993, the year DENV was reintroduced in Panama, until 2011 there were 29 dengue-associated deaths, 17 of which occurred in 2011, the most severe outbreak with a case fatality rate (CFR) of 44% (17 deaths out of 38 severe dengue cases). During this outbreak DENV-2 was reintroduced into the country, whereas over the prior five years DENV-1 and -3 were predominant...
October 3, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28982579/sero-epidemiology-and-hemato-biochemical-study-of-bovine-leptospirosis-in-flood-affected-zone-of-pakistan
#19
Muhammad Ijaz, Syed Nazar Abbas, Shahid Hussain Farooqi, Amjad Islam Aqib, Ghulam Ali Anwar, Abdul Rehman, Muhammad Muddassir Ali, Khalid Mehmood, Amjad Khan
The bovine leptospirosis is an economically important zoonotic disease of flood affected areas worldwide, but scarce information is available about its epidemiology in Pakistan. This is a first study on sero-epidemiology of bovine leptospirosis in Pakistan. The objectives of this study were to investigate the sero-prevalence and associated risk factors of bovine leptospirosis in flood affected zone of Punjab, Pakistan. A total of 385 serum samples were randomly collected from four tehsils of district Muzaffargarh, Pakistan...
October 2, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28982578/zika-and-chikungunya-virus-detection-in-naturally-infected-aedes-aegypti-in-ecuador
#20
Varsovia Cevallos, Patricio Ponce, Jesse J Waggoner, Benjamin A Pinsky, Josefina Coloma, Cristina Quiroga, Diego Morales, Maria José Cárdenas
The wide and rapid spread of Chikungunya (CHIKV) and Zika (ZIKV) viruses represent a global public health problem, especially for tropical and subtropical environments. The early detection of CHIKV and ZIKV in mosquitoes may help to understand the dynamics of the diseases in high-risk areas, and to design data based epidemiological surveillance to activate the preparedness and response of the public health system and vector control programs. This study was done to detect ZIKV and CHIKV viruses in naturally infected fed female Aedes aegypti (L...
October 2, 2017: Acta Tropica
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