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Acta Paediatrica

Lars Walløe, Nils Lid Hjort, Marianne Thoresen
An important neonatal hypothermia (HT) trial on hypoxic-ischemic-encephalopathy was published in November 2017 by Laptook and the NICHD group (1). One hundred and sixty-eight newborn term infants who failed the 6 hour time-window for HT were recruited by 21 centers over an 8 year period into a trial of HT versus normothermia (NT) if they were >6h and <24 hours old. The median postnatal age at start of HT was 16 hours. The infants were cooled for 96 hours, 24 hours longer than the standard 72 hour duration...
November 11, 2018: Acta Paediatrica
Arne Ohlsson
This is a well-designed and executed long-term follow-up study of early use of paracetamol versus placebo on closure of the patent ductus arterioles (PDA) in very preterm infants, born at 235 to 316 post menstrual age (1). The original randomized controlled study (RCT) enrolled 48 infants within 24 hours of birth (2). The study showed that prophylactic paracetamol induced early closure of the ductus arteriosus without detectable side effects (2). This article is protected by copyright. All rights reserved.
November 11, 2018: Acta Paediatrica
M Collet, B Gagnière, C Rousseau, A Chapron, L Fiquet, C Certain
AIM: We explored the associations between childhood exposure to screens, including televisions, computers, game consoles, tablets and smartphones, and primary language disorders. METHODS: This multi-centre case-control study comprised 167 children aged 3.5-6.5 years, who were born in 2010-2012 and diagnosed with primary language disorders, and 109 matched controls without language disorders. Questionnaires were completed by their parents who were recruited by 16 family doctors and 27 speech and language therapists in the Ille-et-Vilaine region of France...
November 11, 2018: Acta Paediatrica
Leif Dotevall
No abstract text is available yet for this article.
November 9, 2018: Acta Paediatrica
Jacqueline Huvanandana, Cindy Thamrin, Murray Hinder, Alistair McEwan, Mark Tracy
AIM: To evaluate cerebral autoregulation changes in preterm infants receiving a loading dose of caffeine base. METHODS: In a cohort of 30 preterm infants, we extracted measures of cerebral autoregulation using time and frequency domain techniques to determine the correlation between mean arterial pressure (MAP) and tissue oxygenation index (TOI) signals. These measures included the cerebral oximetry index (COx), cross-correlation and coherence measures, and were extracted prior to caffeine loading and in the 2 hours following administration of 10 mg/kg caffeine base...
November 7, 2018: Acta Paediatrica
Emilie Moretti, Thameur Rakza, Béatrice Mestdagh, Julien Labreuche, Dominique Turck
AIM: Breastfed infants pass more stools and more liquid stools than formula fed infants and some have no bowel movements or infrequent stools for several days or weeks. We compared exclusively breastfed and exclusively formula fed infants for the first three months. METHODS: This study of 118 infants was carried out in the maternity ward of the Lille University Jeanne de Flandre Hospital, France, in 2015. The outcomes were the number and consistency of stools and the prevalence of infrequent stools...
November 7, 2018: Acta Paediatrica
Amanda G Sandoval Karamian, Fiona M Baumer
No abstract text is available yet for this article.
November 6, 2018: Acta Paediatrica
Bonnie H Arzuaga, Carter Petty, Annie Janvier
AIM: To explore pediatric trainees' experiences and perspectives regarding interactions and relationships between physicians and patients' parents. METHODS: Email survey was sent to AAP Section of Pediatric Trainees members. Trainees were asked about 40 interactions with parents as well as perceived benefits/risks and potential influences. Analysis of associations between variables and perspectives/experiences used chi-square and Fisher exact. RESULTS: 370 surveys were completed...
November 1, 2018: Acta Paediatrica
Gerarda Cappuccio, Annalaura Torella, Mario Mastrangelo, Claudia Carducci, Vincenzo Nigro, Nicola Brunetti-Pierri, Vincenzo Leuzzi
In 2012 Acta Paediatrica published our paper, which reported a possible new form of cerebral folate deficiency, with microcephaly, growth delay, severe intellectual disability and compulsive self-harm behaviour (1). Our patient has now been included in the Telethon Undiagnosed Diseases Program, which aims at providing diagnoses for paediatric patients with an unnamed genetic disease. This article is protected by copyright. All rights reserved.
November 1, 2018: Acta Paediatrica
Laura E Ellington, Elizabeth Jacob-Files, Rosario Becerra, Gabriela Mallma, José Tantalean da Fieno, Katie R Nielsen
AIM: Implementation of healthcare interventions in resource-limited settings remains challenging. This exploratory qualitative study describes social and institutional factors to consider prior to nasal high flow deployment in a middle-income country. METHODS: Researchers conducted 8 nursing focus groups and 4 semi-structured physician interviews at Instituto Nacional de Salud del Niño in Lima, Peru. Participants were identified via purposive sampling. Data were transcribed, translated and coded using a rigorous and iterative process...
November 1, 2018: Acta Paediatrica
Francesco Cavallin, Gaia Pavan, Maria Elena Cavicchiolo, Nicoletta Doglioni, Daniele Trevisanuto
Hypoxic-ischaemic encephalopathy at birth is a rare and unexpected event, affecting 1.5 per 1,000 live births. Appropriate documentation during resuscitation is essential when reviewing the quality of emergency responses and handling medico-legal claims, but it is often unsatisfactory and inaccurate. This retrospective observational study was based on resuscitation data on all neonates with hypoxic-ischaemic encephalopathy born between 1 January 2014 and 31 December 2016 in Eastern Veneto, Italy, who received therapeutic hypothermia...
October 31, 2018: Acta Paediatrica
Jorgen Lous
No abstract text is available yet for this article.
October 30, 2018: Acta Paediatrica
L Emery, E Hamm, K Hague, O Chorna, M Moore-Clingenpeel, N L Maitre
AIM: To compare the effectiveness of an intensive-intermittent vs. standard spaced protocolized music therapy intervention on supporting developmental milestone acquisition of infants >44 weeks post-menstrual age (PMA) hospitalized in a Neonatal Intensive Care Unit (NICU). METHOD: This was a comparative effectiveness study of infants 44-66 weeks PMA with a projected NICU stay of at least one month from recruitment. Infants were randomized to one of two treatment groups: traditional therapy (2x/week) and intermittent-intensive (4x/week, off, 4x/week, off)...
October 30, 2018: Acta Paediatrica
Maria Saito-Benz, Clint Gray, Yu-Chieh Tzeng, Greg Atkinson, Mary J Berry
Regional oxygenation (rSO2 ) by Near Infrared Spectroscopy (NIRS) has the potential to inform vital organ oxygenation and has been advocated as a potential clinical adjunct to the current haemoglobin-based neonatal transfusion guidelines(1). Researchers have demonstrated that transfusion of red blood cells (RBCs) for anaemia of prematurity leads to increases in rSO2 and/or decreases in fractional tissue oxygen extraction (FTOE) in the brain, kidney, gut and muscle up to 24hrs after transfusion(2-4). However, the effects of transfusion on regional oxygenation beyond the initial 24hrs after transfusion are currently not known...
October 29, 2018: Acta Paediatrica
Rose-Marie A Mackay, J Paul Townsend, Jennifer Calvert, Mark Anthony, Andrew R Wilkinson, Anthony D Postle, Howard W Clark, David A Todd
AIM: Sepsis is multifactorial and potentially devastating for preterm neonates. Changes in surfactant protein-D (SP-D), phosphatidylcholine (PC) and PC molecular species during infection may indicate innate immunity or inflammation during sepsis. We aimed to compare these important pulmonary molecules in ventilated neonates without or with sepsis. METHODS: Endotracheal aspirates were collected from preterm neonates born at 23-35 weeks and admitted to the neonatal intensive care unit at the John Radcliffe Hospital, Oxford, UK, from October 2000 to March 2002...
October 29, 2018: Acta Paediatrica
Christopher Andrews, Mary Ann Cooper
We read with interest the recent Brief Report of Maxwell, et al. (1) tragically showing poor foetal outcome following lightning strike, including severe global neuropsychological impairment of the foetus. They suggest this is poorly recognised. While we agree with this assessment, the choice of literature supporting the contention that outcome in pregnancy may be otherwise good after lightning strike derives from electrical, not lightning, trauma. This article is protected by copyright. All rights reserved...
October 29, 2018: Acta Paediatrica
Ulrika Wester Oxelgren, Åsa Myrelid, Göran Annerén, Joakim Westerlund, Jan Gustafsson, Elisabeth Fernell
AIM: We investigated the severities and profiles of intellectual disability (ID) in a population-based group of children with Down syndrome and related the findings to coexisting autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). METHODS: There were about 100 children with Down syndrome living in Uppsala county, Sweden, at the time of the study who all received medical services from the same specialist outpatient clinic. The 60 children (68% male) were aged 5-17 years at inclusion: 41 were assessed within the study and 19 had test results from previous assessments, performed within three years before inclusion...
October 29, 2018: Acta Paediatrica
Jin-Hwa Moon, Sang Yeon Cho, Sung Min Lim, Joo Hyung Roh, Min Sook Koh, Yong Joo Kim, Eunwoo Nam
AIM: We evaluated the relationships between the use of smart devices, such as smartphones and tablet computers, and the development levels and language scores in young children. METHODS: A cross-sectional analysis with 117 children aged three to five years was conducted. The participants were recruited from kindergartens in South Korea between November 2015 and April 2016. Parental questionnaires to assess smart device usage status by children, developmental screening test and receptive-expressive language scale were administered; metrics included smart device usage frequency and usage time, appropriate smart device usage level, developmental levels and language scores...
October 29, 2018: Acta Paediatrica
Elisabetta Venturini, Paola Piccini, Chiara Tersigni, Elena Chiappini, Luisa Galli
AIM: This systematic review aimed to provide an overview of the immunisation of internationally adopted children and to discuss possible vaccination strategies. METHODS: A literature search was performed covering papers published in English from 1988 to 15 June 2018 using the Ovid Medline, Embase and Cochrane Library databases. This identified 749 studies and 41 full texts were evaluated. RESULTS: Overall, 19 studies conducted between 1988 and 2016 fulfilled our inclusion criteria...
October 28, 2018: Acta Paediatrica
Nadja Reissland, Akerke Makhmud, Suzanne Froggatt
Prader-Willi syndrome (PWS) is a complex neuro-genetic disorder with estimated prevalence varying from 1 in 10,000 to 1 in 30,000 with an equal number of males and females affected. A study of the incidence of PWS in France reported thirty-eight infants were diagnosed at a median age of 18 days post birth. None of the cases were identified prenatally. The condition is complex with fetal PWS phenotype including fetal hypo-mobility, polyhydramnios, intra-uterine growth restriction, and immobile flexed extremities with clenched hands or fists, symptoms which are not exclusively pathognomonic to PWS...
October 26, 2018: Acta Paediatrica
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