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Acta Paediatrica

Petter Brattström, Chiara Russo, David Ley, Matteo Bruschettini
AIM: Though caffeine is a consolidated treatment in preterm infants, the efficacy and safety of a higher dose have not been systematically appraised. METHODS: A systematic review was conducted to compare high (loading dose >20 mg/kg and maintenance >10 mg/kg/day) versus low dose of caffeine. MEDLINE, EMBASE, Central, and conference proceedings for randomized controlled trials (RCTs) and quasi-RCTs were searched. Two authors independently screened the records, extracted the data and assessed the risk of bias...
September 22, 2018: Acta Paediatrica
Rossella Parini, Alexander Broomfield, Maureen Anne Cleary, Linda De Meirleir, Maja Di Rocco, Waseem Mahmoud Fathalla, Nathalie Guffon, Christina Lampe, Allan Meldgaard Lund, Maurizio Scarpa, Anna Tylki-Szymańska, Jiří Zeman
AIM: Mucopolysaccharidosis type I is a lysosomal storage disorder that can result in significant disease burden, disability and premature death, if left untreated. The aim of this review was to elaborate on the diagnosis of mucopolysaccharidosis type I and the pros and cons of newborn screening. METHODS: An international working group was established to discuss ways to improve the early diagnosis of mucopolysaccharidosis type I. It consisted of 13 experts in paediatrics, rare diseases and inherited metabolic diseases from Europe and the Middle East...
September 22, 2018: Acta Paediatrica
Pontus Challis, Linn Larsson, Elisabeth Stoltz Sjöström, Fredrik Serenius, Magnus Domellöf, Anders Elfvin
AIM: The definition of necrotising enterocolitis is based on clinical and radiological signs that can be difficult to interpret. The aim of the present study was to validate the incidence of necrotising enterocolitis in the Extremely Preterm Infants in Sweden Study (EXPRESS). METHODS: The EXPRESS study consisted of all 707 infants born before 27+0 gestational weeks during the years 2004-2007 in Sweden. Of these infants, 38 were recorded as having necrotising enterocolitis of Bell stage II or higher...
September 20, 2018: Acta Paediatrica
Torunn Gresdal Rønning, Christina Gabrielsen Aas, Ragnhild Støen, Kåre Bergh, Jan Egil Afset, Mari Sagli Holte, Andreas Radtke
AIM: Klebsiella spp. have been stated to be the most frequent cause of neonatal intensive care unit (NICU) outbreaks. We report an outbreak of Klebsiella oxytoca in a NICU at a tertiary care hospital in Norway between April 2016 and April 2017. This study describes the outbreak, infection control measures undertaken and the molecular methods developed. METHODS: The outbreak prompted detailed epidemiological and microbial investigations, where whole genome sequencing (WGS) was particularly useful for both genotyping and development of two new K...
September 20, 2018: Acta Paediatrica
Elodie Nattes, Danièle Karaa, Laurène Dehoux, Michel Peuchmaur, Theresa Kwon, Georges Deschênes
AIM: Complete or partial resistance to prednisone and calcineurin inhibitors in children with idiopathic nephrotic syndrome often leads to end stage renal disease. The aim of the study was to report the outcome of patients with multidrug resistant nephrotic syndrome treated with an association of immunoglobulin immunoadsorption, intravenous immunoglobulins and B cell depletion. METHODS: At treatment initiation, patients received 10 sessions of immunoglobulin immunoadsorption and intravenous immunoglobulins in two weeks followed by one rituximab in case of remission...
September 19, 2018: Acta Paediatrica
Christer Forsell, Eva Gronowitz, Yvonne Larsson, Britt-Marie Kjellberg, Peter Friberg, Staffan Mårild
AIM: to assess the 4-year outcome in children with obesity randomised to one of two 12-month life-style treatment programs in primary care. METHODS: At baseline, 64 children with obesity aged 8.0-13.0 years were randomised to a treatment program managed either by a nurse, dietician, and physiotherapist (n=32) or by a nurse and dietician (n=32). RESULTS: From baseline to follow-up the mean body mass standard deviation score had decreased by -0...
September 19, 2018: Acta Paediatrica
Anisha Bhatia, Ariel A Salas
No abstract text is available yet for this article.
September 19, 2018: Acta Paediatrica
Anders Batman Mjelle, Hans Jørgen Timm Guthe, Hallvard Reigstad, Anne Lise Bjørke Monsen, Trond Markestad
AIM: To determine serum C-reactive protein (CRP) concentrations in healthy term-born infants shortly after birth. METHODS: We sampled blood from 182 infants along with the routine neonatal screening program at 48-72 hours of age from consecutively recruited healthy infants without signs of infection and a gestational age (GA) of at least 37 weeks. The blood was stored at minus 20°C until analysis in one assay after the end of the study. RESULTS: The CRP levels were positively skewed...
September 17, 2018: Acta Paediatrica
Anastasia Fotaki, Maria Anatoliotaki, Ioanna Tritou, Aggeliki Tzagaraki, Maria Kampitaki, Georgia Vlachaki
AIM: A spinal epidural abscess (SEA) is a rare paediatric bacterial infection, with possible devastating neurologic sequelae. We explored localisation in the cervical segment, which is unusual, but more dangerous, than other SEAs. METHODS: We describe 22 cases (12 male) of paediatric SEAs without risk factors: 21 from a literature search from 2000-2017 and a 30-month-old boy with a spontaneous cervical SEA due to Group A Streptococcus. RESULTS: The average age was eight years and the symptoms were mainly fever, back pain and motor deficit, with an aetiological diagnosis in 68%...
September 17, 2018: Acta Paediatrica
Håkan Kalzén, Tova Hannegård Hamrin, Lars Lindberg, Ola Ingemanson, Peter Radell, Staffan Eksborg
AIM: To investigate if unnecessary harm could be avoided in children admitted to paediatric intensive care (PICU), we analysed the impact of arterial blood gas on the paediatric index of mortality score2 (PIM2) and the derived predicted death rate (PDR). METHODS: From 1 January 2008 to 31 December 2010, 1,793 consecutive admissions, newborn infants to 16 years of age (median 0.71 years) from a single, tertiary PICU in Gothenburg Sweden, were collected. Admission information on arterial oxygen tension (PaO2 ) and fraction of inspired oxygen (FiO2 ) was extracted from 990 admissions...
September 16, 2018: Acta Paediatrica
Niels Lynøe, Anders Eriksson
The main conclusion of the SBU systematic review was that there is insufficient scientific evidence on which to assess the diagnostic accuracy of the triad in identifying traumatic shaking (very low-quality evidence) (1). Laurent-Vannier et al are concerned that this conclusion is used by defence lawyers, but this concern can be understood and respected only if the review was actually flawed (2). The authors duplicate the claims of Debelle et al (3) that the review contains significant flaws and that it should be retracted...
September 14, 2018: Acta Paediatrica
Gerarda Cappuccio, Pia Bernardo, Enza Raiano, Michele Pinelli, Marianna Alagia, Marcello Esposito, Roberto Della Casa, Pietro Strisciuglio, Nicola Brunetti-Pierri, Carmela Bravaccio
Rett syndrome is a severe neurodevelopmental disorder, mostly caused by a MECP2 gene mutation, with some overlaps with autism spectrum disorders and cerebral palsy. Pain perception is potentially abnormal in children with neurodevelopmental disorders and higher levels of pain and discomfort are expected in Rett syndrome, due to issues such as scoliosis, constipation, gastrointestinal problems and self-injuries. Despite this, atypical pain expressions have been reported in Rett syndrome patients that give the impression that they are not in pain (1)...
September 14, 2018: Acta Paediatrica
Veli-Jukka Anttila
No abstract text is available yet for this article.
September 8, 2018: Acta Paediatrica
Agneta Uusijärvi, Ola Olén, Petter Malmborg, Henrik Arnell
We agree that the task of determining whether the cause of recurrent abdominal pain (RAP) in children is organic or functional, may be challenging. Abdominal pain-related functional gastrointestinal disorders are common and characterised by fluctuating symptoms, sometimes with long time symptom-free periods. In our study the diagnostic review was performed by two experienced paediatric gastroenterologists who had access to all patient records until at least 12 months after initial contact. A subgroup of children with RAP in the study by Gijsbers et...
September 8, 2018: Acta Paediatrica
S Manti, G F Parisi, V Giacchi, P Sciacca, L Tardino, C Cuppari, C Salpietro, A Chikermane, S Leonardi
AIM: This study determined cardiovascular impairment in young children with obstructive respiratory disease who were assessed using the opening interrupter technique (RINT). METHODS: This pilot study enrolled 41 children who had been referred to pulmonology and allergology specialists at the University of Catania, Italy, from March to July 2017: 23 (mean age 4.13 ±0.62 years) had chronic coughs and wheezing and 18 controls (mean age 4.27 ±0.66 years) had obstructive chest disease, but were otherwise healthy...
September 8, 2018: Acta Paediatrica
Peter J Anderson
No abstract text is available yet for this article.
September 7, 2018: Acta Paediatrica
Annelie Lindholm, Stefan Bergman, Bernt Alm, Gerd Almquist Tangen, Jovanna Dahlgren, Josefine Roswall
AIM: The aim of the present study was to examine body mass index (BMI) and waist-to-height ratio (WHtR) growth patterns from birth until five years regarding their ability to predict overweight or obesity in children at five years of age. METHODS: Population-based longitudinal birth cohort study of 1,540 children from the south-west region of Sweden, recruited at the first visit to the child health care centres in 2007-2008. The children were followed for five years and classified into two weight groups according to the 2012 International Obesity Task Force criteria...
September 7, 2018: Acta Paediatrica
J Gavin, L V Marino, J J Ashton, R M Beattie
AIM: Maintenance enteral nutrition (MEN) is routinely used in Paediatric Crohn's Disease (CD) to prolong remission although there is limited evidence for efficacy and alack of formal guidelines. This study surveyed patients', parents' and professional experience with MEN. METHODS: Two questionnaires were developed to survey experience of MEN; i) Patients/Parents (children >10 years of age aimed to complete independently) and ii) Dietitians. Questionnaires were sent to families prescribed MEN after exclusive enteral nutrition (EEN) between 2015-17 (n=77) and dietitians working in paediatric regional centres in UK (n=23)...
September 7, 2018: Acta Paediatrica
Keira C Kilmartin, Darragh Finn, Gavin A Hawkes, Mmoloki Kenosi, Eugene M Dempsey, Vicki Livingstone, Anthony C Ryan
AIM: Corrective ventilation strategies (CVS) during neonatal resuscitation and stabilization (R&S) are taught through the MRSOPA mnemonic: Mask adjustment, Repositioning airway, Suctioning, Opening the mouth, Increasing inspiratory Pressure, and Alternative airway. The aim was to examine the use of CVS and to investigate the relationship between MRSOPA strategies and intubation of very preterm infants < 32 weeks' gestation in the delivery room. METHODS: Retrospective review of video recordings of R&S of preterm infants born in Cork University Maternity Hospital, Ireland...
September 7, 2018: Acta Paediatrica
Erik Landfeldt, Thomas Sejersen, Már Tulinius
AIM: Ataluren has been approved for treating nonsense mutation Duchenne muscular dystrophy (nmDMD) and there are currently discussions concerning drug access and applications beyond the development programme. This study provides an overview of nmDMD and ataluren, stipulates clinical rules for treatment initiation and discontinuation and proposes a model the implementation of orphan drugs in clinical practice in Sweden. METHODS: This was a targeted mini review of the literature from 1995-2018, which included cohort studies, guidelines, randomised clinical trials, clinical commentaries and reviews...
September 6, 2018: Acta Paediatrica
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