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Acta Paediatrica

Rikke Pilmann Laursen, Anni Larnkjaer, Christian Ritz, Iva Hojsak, Kim Michaelsen, Christian Mølgaard
AIM: We examined the frequency and potential risk factors for respiratory infections, diarrhoea and absences in infants during their first months in day care. METHODS: This prospective cohort study comprised 269 Danish infants aged 8-14 months and was part of a study that examined how probiotics affected absences from day care due to respiratory and gastrointestinal infections. The risk factors examined were the household, child characteristics and type of day care facility...
March 14, 2018: Acta Paediatrica
Mohammed Qadori, Elmira Flem, Terese Bekkevold, Henrik Døllner, Ann Marit Gilje, Astrid Rojahn, Ketil Størdal
AIM: Using routine blood sampling in a gastroenteritis diagnostic work-up is debatable. This study examined the relationship between the severity of acute gastroenteritis and blood test abnormalities. METHODS: We prospectively enrolled children under five years referred for outpatient or inpatient management for gastroenteritis from February 2014 to April 2016. The four study hospitals cared for 30% of Norwegian children. The severity of gastroenteritis was assessed using Vesikari scores...
March 13, 2018: Acta Paediatrica
Thomas Rossor, Ingran Lingam, Abdel Douiri, Ravindra Bhat, Anne Greenough
AIM: To determine whether a pH probe or multichannel intraluminal impedance (MII) more frequently detected gastro-oesophageal reflux and test the hypothesis that acid reflux was associated with lower baseline impedance. METHODS: A prospective study of infants in whom reflux was suspected and evaluated using combined pH and multichannel impedance. Studies were considered abnormal if the acid index was >10% or there were > 79MII reflux events in 24 hours. The acid index was the percentage of total study time with a pH<four and the acid clearance time (ACT) the time from the pH falling below four to rising above four...
March 13, 2018: Acta Paediatrica
Vinod K Bhutani, M Jeffrey Maisels, David L Schutzman, Martin E Castillo Cuadrado, Janelle L Aby, Debra L Bogen, Robert D Christensen, Jon F Watchko, Ronald J Wong, David K Stevenson
AIM: To identify neonates at risk for haemolytic hyperbilirubinaemia through near-concurrrent measurements of total serum/plasma bilirubin (TB) or transcutaneous bilirubin (TcB) and end-tidal breath carbon monoxide (CO), corrected for ambient CO (ETCOc), an index of bilirubin production and haemolysis. METHODS: Paired TB/TcB (mg/dL) and ETCOc (ppm) measurements were obtained in newborns (n=283) at 20 to <60h of age in five nurseries. TB/TcB values were assigned TB/TcB percentile risk using the Bhutani hour-specific nomogram...
March 13, 2018: Acta Paediatrica
L Bourgoin, L Caeymaex, F Decobert, C Jung, C Danan, X Durrmeyer
AIM: Less invasive surfactant administration (LISA) can avoid tracheal intubation for neonatal respiratory distress syndrome, but can be painful because it requires laryngoscopy. The aim of this study was to assess the efficacy and tolerance of intravenous atropine plus ketamine administration before LISA. METHODS: We conducted a prospective observational study of all premature infants hospitalised in our French neonatal intensive care unit treated with LISA between March 2015 and March 2016...
March 13, 2018: Acta Paediatrica
Idowu O Senbanjo, Mohammed A Salisu, Kazeem A Oshikoya, Uchechukwu O Adediji, Ayodeji O Akinola
AIM: We studied sleep patterns, sleep problems and associated socio-demographic factors among children aged 1-12 years in Lagos, Nigeria. METHODS: This prospective hospital-based study involved 432 children (55% males) who came for routine paediatric care at the Lagos State University Teaching Hospital. Information on socio-demographics, sleeping patterns and specific sleep disorders were obtained. RESULTS: The mean age of the subjects was 5...
March 12, 2018: Acta Paediatrica
M Hermanussen, B Bogin, C Scheffler
AIM: To scrutinize to what extent modern ideas about nutrition effects on growth are supported by historic observations in European populations. METHOD: We reviewed 19th and early 20th century paediatric journals in the Staatsbibliothek zu Berlin, the third largest European library with an almost complete collection of the German medical literature. During a three-day visit, we inspected 15 bookshelf meters of literature not available in electronic format. RESULTS: Late 19th and early 20th century breastfed European infants and children, independent of social strata, grew far below World Health Organisation (WHO) standards and 15-30% of adequately-fed children would be classified as stunted by the WHO standards...
March 11, 2018: Acta Paediatrica
Ryszard Lauterbach, Tobias Strunk, Sanjay Patole, Joanna Hurkała, Dorota Pawlik
Pentoxifylline (PTX) is a methylxanthine with immunomodulating properties that may be beneficial in neonatal sepsis.(1, 2) Mechanisms include inhibition of TLR-mediated inflammation, particularly in cord blood.(3, 4) PTX-related adverse events are rare, including in neonates. Systematic reviews suggest PTX is safe and potentially beneficial in this context.(5) Based on our clinical trials, we have been using PTX for the past 20 years in neonatal sepsis.(2) This article is protected by copyright. All rights reserved...
March 9, 2018: Acta Paediatrica
S Fredheim, P Foli Andersen, G Laerkholm, J Svensson, C B Juhl, B Olsen, K Pilgaard, J Johannesen
AIM: We investigated children's counter regulatory hormone profiles during a hyperinsulinaemic hypoglycaemic clamp procedure at day and night. METHODS: In 2013 we assessed the counter regulatory response to hypoglycaemia in eight outpatients with type 1 diabetes, recruited from the Herlev Hospital, Denmark, at a mean age of 9.6 ±2.3 years. Hyperinsulinaemic 80 mU/m2 /min clamps were performed with a stepwise reduction in plasma glucose from euglycaemia (7-9 mmol/L) to hypoglycaemia (<3...
March 8, 2018: Acta Paediatrica
Gabriel Otterman, Klara Lahne, Elizabeth V Arkema, Steven Lucas, Staffan Janson, Lena Hellström-Westas
AIM: Countries that conduct systematic child death reviews report a high proportion of modifiable characteristics among deaths from external causes and this study examined the trends in Sweden. METHODS: We analysed individual level data on external, ill-defined and unknown causes from the Swedish cause of death register from 2000-2014 and mortality rates were estimated for children under the age of one and for those aged 1-14 and 15-17 years. RESULTS: Child deaths from all causes were 7,914 and 2,006 (25%) were from external, ill-defined and unknown causes: 610 (30%) were infants, 692 (34%) were 1-14 and 704 (35%) were 15-17...
March 8, 2018: Acta Paediatrica
Lauren Beard, Clyde J Wright
No abstract text is available yet for this article.
March 8, 2018: Acta Paediatrica
Barbara Santangelo, Rosa Lapolla, Irene Rutigliano, Massimo Pettoello Mantovani, Angelo Campanozzi
AIM: No data are available on caffeine consumption among Italian adolescents. We investigated caffeine intake from coffee, soft drinks and energy drinks in a sample of Italian adolescents and determined if they exceeded the recommended limits. METHODS: The study comprised 1213 adolescents with a mean age of 15.1 years (range 12-19) from four schools in Foggia, southern Italy. Caffeine intake was assessed using an anonymous self-reported questionnaire during the 2013/2014 school year...
March 7, 2018: Acta Paediatrica
Franca Benini, Emanuele Castagno, Egidio Barbi, Sabrina Congedi, Antonio Urbino, Paolo Biban, Lucia Calistri, Rossella Letizia Mancusi
AIM: The Pain Practice in Italian Paediatric Emergency Departments assessed how appropriately analgesic drugs were being used by Italian clinicians, based on national paediatric pain guidelines. METHODS: This was a retrospective study that involved 17 Italian members of the Pain In Pediatric Emergency Rooms group. It comprised patients up to the age of 14 years who came to hospital emergency departments with pain and were treated with paracetamol, ibuprofen or opioids, such as codeine, tramadol and morphine...
March 5, 2018: Acta Paediatrica
Anat Yerushalmy-Feler, Hagai Soback, Ronit Lubetzky, Amir Ben-Tov, Margalit Dali-Levy, Tut Galai, Shlomi Cohen
AIM: This study described outcomes following treatment for lactose intolerance, which is common in children. METHODS: The medical records of children aged 6-18 years who underwent lactose hydrogen breath testing at Dana-Dwek Children's Hospital, Tel Aviv, Israel, from August 2012-August 2014 were analysed. We compared 154 children with gastrointestinal symptoms and positive lactose hydrogen breath tests to 49 children with negative test results. RESULTS: Of the 154 children in the study group, 89 (57...
March 5, 2018: Acta Paediatrica
Venla Lehti, David Gyllenberg, Auli Suominen, Andre Sourander
AIM: We examined the association between having at least one parent born abroad and being diagnosed with a developmental disorder related to speech and language, academic skills or coordination. METHODS: This nested case-control study was based on Finnish population records for 1996-2007. Cases from the Finnish Hospital Discharge Register were diagnosed with developmental disorders of speech and language, academic skills and coordination by the end of 2012. We identified 28,192 cases and 106,616 matched controls...
March 5, 2018: Acta Paediatrica
Jo Wray, Jenifer Tregay, Catherine Bull, Rachel L Knowles, Sonya Crowe, Katherine Brown
AIM: To elicit the perceptions of helpline staff who talk to parents of children discharged after cardiac surgery in infancy about parents' key concerns. METHODS: A qualitative study involving semi-structured interviews with 10 staff at four heart charities. Interviews were recorded, transcribed and analysed using Framework analysis. RESULTS: Staff identified the knowledge, communication and support needs of parents which they described in terms of the impact of patient and family factors, sources of support and systems...
March 5, 2018: Acta Paediatrica
Hilde Brenne, Kristine Hermansen Grunewaldt, Turid Follestad, Håkon Bergseng
AIM: We measured electrical activity of the diaphragm (Edi) to compare the breathing effort in preterm infants during weaning from respiratory support with high-flow nasal cannulae (HFNC) or nasal continuous positive airway pressure (nCPAP). METHODS: This randomised cross-over study was carried out at St Olav's University Hospital, Trondheim, Norway from December 2013 to June 2015. We gave 21 preterm infants weighing at least 1,000 grams HFNC 6 l/min for four hours and nCPAP 3 cmH2 O for four hours with a one-hour wash-out period...
March 5, 2018: Acta Paediatrica
Hua-Hong Wu, Hui Li, Ya-Qin Zhang, Xin-Nan Zong, Zong-Han Zhu, Yang Yu
AIM: This 2015 study was part of The National Growth Survey of Children under seven years of age, which has been carried out in nine Chinese cities every 10 years since 1975. Our aim was to assess children's feeding practices and nutritional supplements. METHODS: This was a cross-sectional survey of 89,006 healthy children aged one to 24 months. All data were collected by face-to-face interviews during child health visits, using a questionnaire. RESULTS: The exclusive breastfeeding rate was 53% in infants under six months of age and the continued breastfeeding rate was 51% among infants who were 10-12 months and 5% when they were 21-24 months...
March 2, 2018: Acta Paediatrica
Britt Frisk Pados, Suzanne M Thoyre, Jinhee Park
AIM: To determine reference values for the Child Oral and Motor Proficiency Scale (ChOMPS) based on healthy, typically-developing and typically-eating children between 6 months and 7 years old. METHODS: Parents of children 6 months to 7 years old (n=1057) completed the 63-item ChOMPS. Median, range, 5th and 10th percentiles were calculated for scores on the four subscales of the ChOMPS as well as the total score in each of 11 age groups. RESULTS: Age-based norm-reference values are reported...
February 27, 2018: Acta Paediatrica
Agneta Uusijärvi, Ola Olén, Petter Malmborg, Martina Eriksson, Peter Grimheden, Henrik Arnell
AIM: This study aimed to validate the Rome III criteria and alarm symptoms with regard to their ability to discriminate between organic and functional diagnoses in children with gastrointestinal complaints. METHODS: We recruited 258 children aged 4-17 years who consulted a paediatrician in secondary or tertiary care in Stockholm from January 2013 to May 2014 due to gastrointestinal complaints. A symptom questionnaire based on the official Questionnaire on Pediatric Gastrointestinal Symptoms Rome III, including questions on alarm symptoms, was used...
February 27, 2018: Acta Paediatrica
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