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Acta Paediatrica

Isabel Benavente-Fernandez, Manuel Lubián-Gutierrez, Gema Jimenez-Gomez, Alfonso M Lechuga-Sancho, Simon P Lubián-López
AIM: Post-haemorrhagic ventricular dilatation is monitored by conventional two-dimensional ultrasound. The aims of this study were to determine the volume of the lateral ventricles using three-dimensional ultrasound in preterm infants with post-haemorrhagic ventricular dilatation and evaluate the relationship between volume and linear measurements. METHODS: Serial two-dimensional ultrasounds and three-dimensional ultrasounds were performed on preterm infants with post-haemorrhagic ventricular dilatation admitted to the neonatal intensive care unit at Puerta del Mar Hospital, Cádiz, Spain, from January 2013 to December 2014...
October 26, 2016: Acta Paediatrica
D Finn, A Dorrian, J Sheehy, E M Dempsey, C A Ryan
AIM: To determine the neonatal incidence, indications and outcomes following transfusions with emergency uncrossmatched O-negative blood. METHODS: A 5 year retrospective review in a single tertiary neonatal unit was conducted. The blood transfusion laboratory's database was analysed for all infants who had received an emergency released blood transfusion (ERBT) between January 2010 - December 2014. RESULTS: We calculated a total ERBT rate of 0...
October 26, 2016: Acta Paediatrica
Amit Mukerji, Prakesh S Shah, Sandesh Shivananda, Wendy Yee, Brooke Read, John Minski, Ruben Alvaro, Christoph Fusch
AIM: To evaluate practice variation with respect to non-invasive respiratory support (NRS) use across Canadian neonatal intensive care units (NICUs). METHODS: A web-based survey was sent to all site investigators of the 30 level 3 NICUs participating in the Canadian Neonatal Network. The survey inquired about the use of five commonly described NRS modes. In addition, the presence and adherence to local guidelines were ascertained. Descriptive analyses were performed to identify variations in practice...
October 26, 2016: Acta Paediatrica
Matti Uhari
Enterobacteriaceae can produce β-lactamases that are capable of hydrolysing extended-spectrum cephalosporins, namely cefotaxime, ceftriaxone, ceftizoxime and ceftatzidime. Today there are more than 1,600 different known β-lactamases (1) and, although the first reports of extended spectrum beta-lactamases (ESBL) were from Germany and England, ESBL producing bacteria have been particularly common in France (2). This article is protected by copyright. All rights reserved.
October 20, 2016: Acta Paediatrica
Francesco Savino, Andrea Quartieri, Angela De Marco, Maria Garro, Alberto Amaretti, Stefano Raimondi, Marta Simone, Maddalena Rossi
AIM: This study compared the faecal microbial composition of formula-fed infants who did and did not have colic. METHODS: Faecal samples from formula-fed infants under 16 weeks of age with (n=38) and without (n=39) colic were collected at Department of Pediatrics in Turin, Italy, between February 2014 and October 2015. The pH and faecal ammonia were determined and total bacteria, bifidobacteria, lactic acid bacteria (LAB) and coliforms were quantified by fluorescent in situ hybridisation (FISH)...
October 20, 2016: Acta Paediatrica
E Ylinen, L Salmela, J Peräsaari, T Jaatinen, A Tenca, O Vapalahti, M Färkkilä, H Jalanko, K-L Kolho
AIM: The human leukocyte antigen (HLA) allele and haplotype frequencies of the Finnish population are unique because of the restricted and homogenous gene population. There are no published data on HLA genotype associations in paediatric autoimmune liver diseases in Scandinavia. This study characterised the HLA genotypes of children with autoimmune liver or biliary disease in Finland. METHODS: The study cohort comprised 19 paediatric patients (13 female) aged 3-15 years treated for autoimmune liver or biliary disease at the Children's Hospital, Helsinki University Hospital, between 2000 and 2011 and followed up for 4...
October 19, 2016: Acta Paediatrica
L Mo-Suwan, E McNeil, P Sangsupawanich, U Chittchang, C Choprapawon
AIM: The association between adiposity rebound and insulin resistance in middle childhood has seldom been studied. We examined the effect of body mass index (BMI) velocity and early adiposity rebound on the insulin resistance of prepubertal children. METHODS: BMI data from a longitudinal follow-up of a birth cohort in Thailand were used. The homeostatic model assessment of insulin resistance (HOMA-IR) was calculated from 12-hour fasting plasma glucose and serum insulin at 8...
October 19, 2016: Acta Paediatrica
Hong Ren, Zhixiong Zhou, Wenxi Kevin Liu, Xiujiang Wang, Zenong Yin
AIM: This study examined the relationships between energy balance-related behaviours outside school hours and obesity in Chinese primary school students. We also explored the influence of gender on those relationships. METHODS: The study sample was a cross-sectional cohort of 5,032 Chinese children who were enrolled in grades 1-6 in primary schools in five Chinese cities and whose mean ages ranged from 7.3 to 11.9 years. The children's parents completed a survey on their child's height, weight and energy balance-related behaviours outside school hours...
October 19, 2016: Acta Paediatrica
Yun Wang, Mei Yang, Zhiqiang Huang, Lang Tian, Lu Niu, Shuiyuan Xiao
AIM: This study aimed to test the association between fathers' smoking behaviour and urinary cotinine levels among preschool children exposed to environmental tobacco smoke (ETS). Possible factors influencing this association were also explored. METHODS: We recruited 368 smoking fathers with children aged 5-6 from five preschools in the city of Changsha, China. Urine samples were collected from the children and the fathers were interviewed face-to-face. We adjusted for potential confounding factors with linear regression models...
October 17, 2016: Acta Paediatrica
Kyriaki A Karavanaki, Alexandra Soldatou, Athina Maria Koufadaki, Charalampos Tsentidis, Fotis A Haliotis, Constantinos J Stefanidis
AIM: This study evaluated the controversial relationship between the duration of fever before treatment initiation (FBT) for a febrile urinary tract infection (UTI), with renal scarring based on dimercaptosuccinic acid scintigraphy (DMSA) findings. METHODS: The inpatient records of 148 children under two years of age with a first episode of febrile UTI were analysed. Acute and repeat DMSA findings, clinical and laboratory parameters were evaluated. RESULTS: Acute DMSA showed that 76 of the 148 children with a febrile UTI had renal lesions: 20 were mild and 56 were moderate or severe...
October 17, 2016: Acta Paediatrica
Alice Lejeune, Luise Martin, Sabine Santibanez, Stephanie Thee, Alexander Gratopp, Peter Späth, Annette Mankertz, Tilmann Kallinich, Horst von Bernuth
Most non-immune individuals exposed to the highly contagious measles virus will develop measles. Complications, such as encephalitis and bacterial infections due to measles virus-induced immunomodulation, account for an acute mortality rate of approximately 0.1% (1). It has been calculated that measles-related immunomodulation may last for several years and may contribute to child mortality on a larger scale than acute measles-related mortality (2). Since humans provide the only host for the virus, and an efficient vaccine is available, it is possible to eliminate measles...
October 17, 2016: Acta Paediatrica
Anders Breinbjerg, Charlotte Siggaard Rittig, Niels Gregersen, Søren Rittig, Jane Hvarregaard Christensen
AIM: Bartter syndrome is an autosomal recessive inherited disease in which patients present with hypokalaemia and metabolic alkalosis. We present two apparently non-related cases with antenatal Bartter syndrome type I, due to a novel variant in the SLC12A1 gene encoding the bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 in the thick ascending limb of the loop of Henle. METHODS: Blood samples were received from the two cases and 19 of their relatives and deoxyribonucleic acid was extracted...
October 17, 2016: Acta Paediatrica
Ida Lindblad, Salmir Nasic, Magnus Landgren, Leif Svensson, Christopher Gillberg, Elisabeth Fernell
AIM: There are few long-term studies of adaptive functions as an outcome measure of pharmacological treatment in attention deficit hyperactivity disorder (ADHD).This study assessed the adaptive abilities of children with ADHD before and after several years of pharmacological treatment. METHOD: We studied 12 children with a mean age of 15 years - seven boys and five girls - who had continued pharmacological treatment for ADHD for more than four years. The Adaptive Behavior Assessment Scales - Second Edition ratings by their teachers were compared before and after they had received treatment for ADHD...
October 15, 2016: Acta Paediatrica
Ilaria Di Giovanni, M Loredana Marcovecchio, Valentina Chiavaroli, Tommaso de Giorgis, Francesco Chiarelli, Angelika Mohn
AIM: Perinatal factors seem to influence the onset of puberty, but there is limited information on the potential effect of large size at birth on pubertal growth. This study evaluated pubertal growth in children born large for gestational age (LGA) compared to children born appropriate for gestational age (AGA). METHODS: Longitudinal growth data collected from 70 children - 40 AGA and 30 LGA - were analysed. The ages at take-off, peak height velocity, final height and pubertal growth spurts were calculated using the Preece-Baines model one...
October 15, 2016: Acta Paediatrica
Eun Lee, Jisun Yoon, Soo-Jong Hong, Jinho Yu
AIM: We investigated airway function in preschoolers with post-infectious bronchiolitis obliterans (PIBO) using impulse oscillometry (IOS). METHODS: This study enrolled 182 children aged 3-5 years: 12 with PIBO, 135 asthma with asthma and 35 non-atopic controls. Respiratory resistance and reactance were assessed using IOS. RESULTS: The percentage predicted (% predicted) of pre-bronchodilator respiratory resistance at 5Hz was significantly higher in children with PIBO (177...
October 15, 2016: Acta Paediatrica
Rachel Bello, Yael Lebenthal, Liora Lazar, Shlomit Shalitin, Ariel Tenenbaum, Moshe Phillip, Liat de Vries
AIM: This study explored whether using the suggested diagnostic serum basal level of 17-hydroxyprogesterone (6.0 nmol/l) would lead to underdiagnosis of non-classical congenital adrenal hyperplasia. METHODS: We retrospectively studied 123 patients with non-classical congenital adrenal hyperplasia, defined as an adrenocorticotropic hormone-stimulated 17-hydroxyprogesterone level of more than 45nmol/l. Of these 13 had basal 17-hydroxyprogesterone levels of less than 6...
October 15, 2016: Acta Paediatrica
Cristiane Ribeiro Ambrósio, Adriana Sanudo, Maria Fernanda Branco de Almeida, Ruth Guinsburg
AIM: The aim of this study was to survey paediatricians, who taught neonatal resuscitation in Brazil, about when they would apply advanced resuscitation in the delivery room for newborn infants born at 23-26 weeks of gestational age. METHODS: This cross-sectional study focused on an electronic questionnaire that was sent to paediatricians who acted as instructors for the Brazilian Neonatal Resuscitation Program from December 2011 to September 2013. The primary outcome was the gestational age at which the respondent would apply advanced resuscitation in the delivery room...
October 14, 2016: Acta Paediatrica
Rutger Bennet, Margareta Eriksson
AIM: This study described the epidemiology and clinical features of childhood tuberculosis (TB) in Stockholm over a 45-year period, when there was a resurge of tuberculosis concomitant with increased immigration. METHODS: We describe 220 children up to the age of 16 years with active TB, seen at the Astrid Lindgren Children's Hospital from 1971-2015. The study period was divided into three 15-year periods. RESULTS: Cases increased from 10 children in 1971-1985 to 76 in 1986-2000 and 134 in 2001-2015, with overall incidence increasing from <1 to four per 100,000...
October 14, 2016: Acta Paediatrica
C M Wickramatilake, R A Dharmadasa, M H A D De Silva
Lower respiratory tract infections (LRTIs) in children are a frequent health problem and, although the majority of LRTIs are self-limiting, most of the children who develop them receive antibiotic treatment (1). The main objective of our study was to determine the pattern of antibiotic use among children with LRTIs admitted to pediatric units in a tertiary care centre in Southern Sri Lanka. This was a descriptive, cross-sectional study and was conducted over a one-year period from 1 January to 31 December 2013...
October 14, 2016: Acta Paediatrica
T Irevall, I Axelsson, E Naumburg
AIM: Adverse neurological symptoms have been linked to vitamin B12 deficiency in infants. This explorative study described the clinical presentation associated with vitamin B12 deficiency in this age group. METHODS: The study comprised infants who were born between 2004-2012 and were tested for vitamin B12 levels after they were admitted to a hospital with neurological symptoms at less than one year of age. Vitamin B12 deficiency was defined as low cobalamin in serum and, or, increased homocysteine and, or, increased methylmalonate...
October 13, 2016: Acta Paediatrica
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