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Acta Paediatrica

R Rasul, M Ward, S Clews, J Falconer, J Feller, K Lui, J Oei
AIM: We determined the safety, feasibility and sustainability of an outpatient model of care for infants exposed to intra-uterine drugs. METHODS: This was a retrospective chart review of 774 drug-exposed infants born between 1998-2016 at the Royal Hospital for Women, Sydney, Australia. RESULTS: Most (86%) of the mothers used multiple drugs, including opioids (58%). More than three-quarters (78%) of the infants were born full term at a mean gestation of 38 weeks and hospitalised for a median of seven days...
July 21, 2018: Acta Paediatrica
Stefan Kutzsche
John Langdon Down (1828-1896) had a long-standing interest in the connection between ethnicity and mental health and he believed in Charles Darwin's theory of evolution. In 1866 he became the first clinician to identify a specific group of patients with Mongolian characteristics and suggested that they were very responsive to treatment (1). But it took nearly 100 years for this condition to be named Down syndrome. This article is protected by copyright. All rights reserved.
July 20, 2018: Acta Paediatrica
Junko Yoshimoto, Takashi Yorifuji, Yosuke Washio, Tomoka Okamura, Hirokazu Watanabe, Hiroyuki Doi, Hirokazu Tsukahara
AIM: We examined the effects of being born small for gestational age (SGA) on the risk of being hospitalised for common diseases during childhood. METHODS: This Japanese nationwide, population-based longitudinal survey followed babies born before 42 weeks of gestation from 10-17 January and 10-17 July 2001, using data from the Government's Longitudinal Survey of Babies in the 21st Century. Our study followed 41,268 children until 5.5 years of age: 39,107 full-term (8...
July 20, 2018: Acta Paediatrica
I Alberici, A La Manna, M Pennesi, M Starc, F Scozzola, G Nicolini, A Toffolo, G Marra, R Chimenz, F Sica, S Maringhini, L Monasta, G Montini
AIM: in 2009 the Italian society for paediatric nephrology suggested the need for cystography, following a first febrile urinary tract infection (UTI), only in children at high-risk for dilating vesico-ureteral reflux or in the event of a second infection. The aim of this study was to evaluate the adequacy of the risk factors proposed by the Italian guidelines. METHODS: children aged two to 36 months, managed by 10 Italian hospitals between 2009 and 2013, with a first febrile UTI were retrospectively evaluated...
July 20, 2018: Acta Paediatrica
Matti Korppi, Johanna Teräsjärvi, Juho Vuononvirta, Milla Liehu-Martiskainen, Heini Huhtala, Liisa Kröger, Laura Pöyhönen, Qiushui He
Finnish newborns were vaccinated with Bacillus Callmette-Guerin (BCG) vaccine from 1940s until 2006. The diagnostics of severe complications after vaccination was centralised until 1988, and 222 children presented with BCG osteitis from 1960 to 1988 (1). Pattern-recognition receptors (PRR), such as toll-like receptors (TLR), recognise surface structures of pathogens and initiate inflammatory and immune responses in the host (2) Cytokines, such as tumor necrosis factor (TNF), interferons (IFN) and interleukins (IL) are important mediators in these responses...
July 20, 2018: Acta Paediatrica
Pierre Kuhn, Jacques Sizun, Charlotte Casper
AIM: Hospitalised newborn infants may be stressed due to inappropriate sensory stimuli and early separation from their families, that can negatively impact their neurodevelopment. The French Group of Reflection and Evaluation of the Environment of Newborns (GREEN) issues guidelines based on environmental neonatology and family centred care. The first recommendation focuses on private family rooms versus large shared rooms. METHODS: These guidelines are based on a systematic evaluation of the literature providing different grades of evidence...
July 19, 2018: Acta Paediatrica
Afrodite Psaros Einberg, Björn Fischler
The use of interferon free, oral direct acting antiviral (DAA) combination therapy has in the last few years rapidly changed the care for adult patients with chronic hepatitis C virus (HCV) infection (1). Their strong efficacy, with sustained viral response (SVR) rates of 90-95% and a very low burden of side effects, has prompted considerations for paediatric usage (2). Results from the first controlled paediatric trials are equally promising and subsequently combination therapy, with sofosbuvir and ledipasvir for genotypes 1 and 4 and sofosbuvir and ribavirin for genotypes 2 and 3, is now licensed for patients above 12 years of age (2)...
July 19, 2018: Acta Paediatrica
Niels Lynøe, Anders Eriksson
Since the publication of the Swedish systematic literature review on the diagnostic accuracy of the triad of signs and symptoms and shaken baby syndrome (1), several authors have commented on the arguments for classifying most previous studies as having a high risk of bias (2-4). The main reason for this classification is that scientists have used the clinical judgments of child protection teams as the reference test when classifying shaken baby cases (1). Since the diagnostic tests depend on this reference test, the outcome will be a high risk of bias (5,6)...
July 19, 2018: Acta Paediatrica
Mireia Adelantado-Renau, Maria Reyes Beltran-Valls, Irene Esteban-Cornejo, Vicente Martínez-Vizcaíno, Alba María Santaliestra-Pasías, Diego Moliner-Urdiales
AIM: This study examined the association of adherence to the Mediterranean diet with academic performance and tested whether this association was mediated by sleep in Spanish adolescents. METHODS: We recruited 269 adolescents (52% boys) aged 13.9 ± 0.3 years from the Deporte, ADOlescencia y Salud study of 38 secondary schools and sport clubs in Castellon, Spain, between February and May 2015. Adherence to the Mediterranean diet was assessed by the KIDMED questionnaire, sleep quality was evaluated with the Pittsburgh Sleep Quality Index test and sleep duration was objectively computed using a wrist-worn accelerometer...
July 17, 2018: Acta Paediatrica
Göran Wennergren
No abstract text is available yet for this article.
July 13, 2018: Acta Paediatrica
V Georgieva, W Kamolvit, M Herthelius, P Lüthje, A Brauner, M Chromek
AIM: Vitamin D stimulates production of the endogenous antimicrobial peptides cathelicidin and β-defensin-2, which are expressed in the urinary tract. We investigated vitamin D status and levels of cathelicidin and β-defensin-2 and their association with urinary tract infection. METHODS: The study included 120 children under three years of age: 76 children with urinary tract infection and 44 otherwise healthy children with congenital hydronephrosis. Serum 25-hydroxycholecalciferol levels were measured by direct competitive electro-chemiluminescence immunoassay, and plasma cathelicidin and β-defensin-2 concentrations were analysed by enzyme-linked immunosorbent assay...
July 13, 2018: Acta Paediatrica
Erik Wejryd, Giovanna Marchini, Veronica Frimmel, Baldvin Jonsson, Thomas Abrahamsson
AIM: This study evaluated if oral supplementation with the probiotic bacterium Lactobacillus reuteri DSM 17938 improved enteral feeding tolerance and growth rates in extremely low birth weight infants. METHOD: A randomised, double-blind, placebo-controlled trial comprising 134 extremely low birth weight (<1,000g) infants born before gestational week 28+0. Daily supplementation of L. reuteri (1.25 x 108 bacteria/day) or placebo started within 3 days and continued until gestational week 36+0...
July 12, 2018: Acta Paediatrica
Seung Kim, Sowon Park, Hong Koh, Yunkoo Kang, Namkyung Kwon
AIM: We evaluated how well medical staff or parents understood patients with inflammatory bowel disease (IBD) by comparing their evaluation of the patients' quality of life (QoL) with the patients' self-reported QoL. METHODS: This study was carried out at Severance Children's Hospital in Seoul, Korea, in 2017. The children with IBD were recruited from August 2017 to December 2017 and they had a mean age of 16.4 (range 9.3-18.9) years. We asked the 64 children (38 boys), 58 mothers, 16 fathers, three physicians and one IBD nurse to answer the IMPACT-III questionnaire, which measures QoL, and compared the scores...
July 12, 2018: Acta Paediatrica
Arianne H Teeuw, Rik B J Kraan, Rick R van Rijn, Patrick M M Bossuyt, Hugo S A Heymans
AIM: We studied the accuracy of a screening checklist (SPUTOVAMO), complete physical examination (top-to-toe inspection, TTI) and their combination in detecting child abuse in the emergency department (ED). METHODS: Consecutive patients admitted to the ED of the Academic Medical Center in Amsterdam between January 2011 and 1 July 2013 were included. An Expert Panel assigned a consensus diagnosis to positive cases. For all other and missed cases, the Child Abuse Counselling and Reporting Centre diagnosis was used...
July 10, 2018: Acta Paediatrica
A Kelso, K Vogel, J M Steinacker
AIM: A standard approach to measure subcutaneous adipose tissue (SAT) using ultrasound has proved successful in adults, but has not been studied in children. This study addressed that gap in children aged 3-5 years. METHODS: In autumn 2016, 24 preschools in Southwest Germany, recruited via mail, agreed to take part in this study and 274 children (51.4% boys) with a mean age of 4.6 ±0.7 years participated in measurements of SAT and anthropometry. Differences in measurements were explored between the sexes and anthropometric predictors of mean SAT thickness were identified...
July 10, 2018: Acta Paediatrica
Alan Leviton, Elizabeth N Allred, Robert M Joseph, T Michael O'Shea, Joseph Majzoub, Karl C K Kuban
AIM: To evaluate the relationship between corticotropin-releasing hormone (CRH) expression in the placenta and the risk of school-related dysfunctions at age 10 years among children born extremely preterm (EP). METHODS: CRH expression was measured in the placenta of 761 EP children, who had the following assessments at age 10 years: Differential Ability Scales, Oral and Written Language Scales, the Wechsler Individual Achievement Test-III, NEPSY-II, and the Child Symptom Inventory-4...
July 10, 2018: Acta Paediatrica
Susanna Salmivesi, Matti Korppi
Cows' milk allergy (CMA), mediated by immunoglobulin-E, is the most common food allergy in young children. Although CMA normally resolves by itself at an early age, a remarkable proportion of children will remain allergic to milk at school age (1). The only treatment option that has previously been available has been to avoid milk and milk products and challenging the patients to consume milk at regular intervals, for example every 6-12 months. This article is protected by copyright. All rights reserved.
July 10, 2018: Acta Paediatrica
Heikki Peltola, Markus Pääkkönen
No abstract text is available yet for this article.
July 6, 2018: Acta Paediatrica
Peder Annaeus Granlund, Jostein Strand Ødegaard, Håvard Ove Skjerven, Karin C Lødrup Carlsen, Katarina Hanséus, Ingolfur Rögnvaldsson, Jan Sunnegårdh, Maila I Turanlahti, Henrik Holmstrøm
AIM: This study determined the use of standardised procedures for infant non-invasive blood pressure (NIBP) measurements in the Nordic countries and aimed to identify factors included in the standardisation and interpretation of NIBP measurements in infants. METHODS: A cross-sectional electronic questionnaire survey was sent to 84 physicians in all 23 university hospitals in Sweden, Norway, Denmark, Finland and Iceland and was completed from February to March 2017...
July 6, 2018: Acta Paediatrica
Carolien F M Gijsbers
First, organic diagnoses were found in 42 children (16%), but how did the clinicians determine the causal relationships between the abnormalities they found, such as anal fissures and lactose malabsorption, and the patients' symptoms? In general, expert diagnoses are not transparent and reproducible without any criteria for causal relationships. Our paper on clinical diagnoses of abdominal pain used criteria based on therapeutic interventions and follow up. These were that treatment of the suspected cause was successful, the abdominal pain disappeared within a reasonable period of time and it did not reappear within six months or it reappeared, apparently due to the same cause, and was eliminated in the same way (2)...
July 4, 2018: Acta Paediatrica
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