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Acta Paediatrica

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https://www.readbyqxmd.com/read/28520217/the-gene-encoding-the-inwardly-rectifying-potassium-channel-kir4-1-may-be-involved-in-sudden-infant-death-syndrome
#1
Siri H Opdal, Åshild Vege, Arne Stray-Pedersen, Torleiv O Rognum
AIM: Disturbances in brain function and development may play a role in sudden infant death syndrome (SIDS). This Norwegian study aimed to test the hypothesis that specific variants of genes involved in water transport and potassium homeostasis would be predisposing factors for SIDS. METHODS: Genetic variation in the genes encoding aquaporin-4 (AQP4), Kir4.1 (KCNJ10) and α-syntrophin were analysed in 171 SIDS cases (62.6% male) with a median age of 15.5 (2-52) weeks and 398 adult controls (70...
May 18, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28520183/infected-malnourished-children-displayed-changes-in-early-activation-and-lymphocyte-subpopulations
#2
Oralia Nájera-Medina, Fernando Valencia-Chavarría, Consuelo Cortés-Bejar, Monika Palacios-Martínez, C Paulina Rodríguez-López, María Cristina González-Torres
AIM: Malnutrition and infections cause immunological changes in lymphocyte subpopulations and their functionality. We evaluated the activation capacity of lymphocytes and memory cells in 10 well nourished, seven well nourished infected and eight malnourished infected children before and after treatment. METHODS: All the children were patients in Mexico City and were less than three years of age. The expression of various cluster of differentiation (CD) cells were assessed by flow cytometry: CD45RA (naïve) and CD45RO (memory) antigens on CD4 lymphocytes and CD69 in all lymphocytes...
May 18, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28520106/prophylactic-sustained-inflation-is-just-one-step-to-preventing-bronchopulmonary-dysplasia
#3
G Lista, I Bresesti
I am glad to see that the Sustained Lung Inflation (SLI) trial (1) still draws a great deal of attention and I would like to clarify some aspects of the trial, in response to the comments by Gupta and Argarwal (2) in Acta Paediatrica. A meta-analysis carried out in 2016 demonstrated that starting non-invasive respiratory support from birth could reduce the incidence of bronchopulmonary dysplasia and death. However, about 50% of very low birth weight infants who are initially on nasal continuous positive airway pressure need subsequent intubation and mechanical ventilation...
May 18, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28520104/use-of-time-and-adolescent-health-related-quality-of-life-wellbeing-a-scoping-review
#4
REVIEW
Monica Wong, Kate Lycett, Tim Olds, Lisa Gold, Melissa Wake
Time use could profoundly affect adolescents' health-related quality of life (HRQL). Ideally, overall time use patterns would be considered, because activities within a 24-hour day are inherently correlated (more in one activity means less in another). This review focused on the associations of 1) overall time use patterns and 2) components of time use patterns with HRQL in adolescents. CONCLUSION: More physical activity, less screen time and more/adequate sleep, in isolation, are associated with better profile-based HRQL subscales...
May 18, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28513002/one-oxygen-breath-shortened-the-time-to-return-of-spontaneous-circulation-in-severely-asphyxiated-piglets
#5
Rikard Linner, Doris Cunha-Goncalves, Valeria Perez-de-Sa
AIM: Asphyxiated neonates should be resuscitated with air, but it remains unclear if oxygen supplementation is needed in ineffectively ventilated newborn infants. We studied the return of spontaneous circulation (ROSC) with oxygen or air in an experimental model of inadequate ventilation. METHODS: Asphyxia was induced in 16 newborn piglets until their heart rate was <60 bpm or mean arterial pressure (MAP) <30 mmHg. During the first 10 minutes of resuscitation, they received one breath per minute of oxygen (n=8) or air (n=8)...
May 16, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28510985/changing-diagnosis-coding-routines-may-confound-the-results-of-longitudinal-childhood-pneumonia-studies
#6
M Eriksson, A Nilsson, R Bennet
AIM: This Swedish study compared the discharge diagnosis codes used for children up to the age of five hospitalised for acute lower respiratory tract infections before and after the introduction of the pneumococcal conjugate vaccine in 2007. METHODS: The International Classification of Diseases - 10(th) revision codes were used. We compared the discharge diagnosis codes at the Astrid Lindgren Children's Hospital from 1 July 2005 to 30 June 2007 (n=1,127) and 1 July 2011 to 30 June 2013 (n=1,240) in relation to the diagnostic methods used...
May 16, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28510350/real-life-comparison-of-three-general-paediatric-wards-showed-similar-outcomes-for-children-with-bronchiolitis-despite-different-treatment-regimens
#7
Einat Shmueli, Tal Berger, Yonatan A Herman, Gabriel Chodick, Eran Rom, Efraim Bilavsky, Liat Ashkenazi-Hoffnung, Shai Ashkenazi, Jacob Amir, Dario Prais
AIM: This study evaluated the effectiveness of three different treatments for bronchiolitis in a tertiary pediatric facility. METHODS: Patients with bronchiolitis who were younger than two years of age and were randomly allocated to three general wards at Schneider Children's Medical Center, Israel, after admission were included. Different treatment protocols in the wards were retrospectively compared. RESULTS: The study comprised 286 children...
May 16, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28508419/case-control-study-shows-that-neonatal-pneumococcal-meningitis-cannot-be-distinguished-from-group-b-streptococcus-cases
#8
Alexandra Arfi, Robert Cohen, Emmanuelle Varon, Stéphane Béchet, Stéphane Bonacorsi, Corinne Levy
AIM: Streptococcus pneumoniae (S. pneumoniae) is sometimes implicated in neonatal bacterial meningitis. This study described the demographic, clinical and biological features of neonatal S. pneumoniae meningitis and compared pneumococcal and group B streptococcal (GBS) neonatal meningitis. METHODS: We conducted a case-control study that compared neonates, aged one to 28 days with S. pneumoniae meningitis or GBS meningitis. Each case with S. pneumoniae was randomly matched to four control patients with GBS by age group and study year...
May 16, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28508412/nicotine-withdrawal-syndrome-in-a-newborn-baby-after-maternal-use-of-oral-applied-moist-tobacco-snus-should-result-in-greater-awareness-to-the-use-of-snus-among-pregnant-women
#9
Dag Helge Frøisland
The harm that smoking causes the fetus are well known. Smoking by young men and women in Scandinavia has steadily declined in the last few decades and the use of snus - moist tobacco that is placed in the mouth - has increased. This patient history highlights the effects of using snus during pregnancy This article is protected by copyright. All rights reserved.
May 16, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28503824/an-index-to-predict-asthma-in-wheezing-young-children-produced-promising-initial-results
#10
Bill Hesselmar, Robert Saalman, Göran Wennergren, Mainor Åmark, Agnes E Wold, Ingegerd Adlerberth, Nils Åberg
Diagnosing asthma is difficult in infants and preschool children because wheezing is common in this age group and it is not synonymous with asthma. Some children outgrow the tendency to wheeze during colds in a few years' time, whereas other develop asthma. Efforts have been made to find ways to identify the subgroup of preschool children with wheeze who are most likely to develop asthma (1,2). However, the different asthma predictive indexes mainly aim to predict children who will have a persistent wheeze or asthma, not necessarily the subgroup who will outgrow their symptoms...
May 15, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28503800/secular-trends-in-australian-school-children-s-sleep-and-perceived-importance-of-sleep-between-1985-and-2013
#11
James Dollman, Lisa Matricciani, Verity Booth, Sarah Blunden
AIM: To examine secular trends in Australian children's actual sleep time as well as the perceived importance of sleep between 1985-2004-2013. METHODS: Secular trends in children's sleep and their perception of the importance of sleep across three time points 1985 (N=401), 2004 (N=450) and 2013 (N=395), were examined according to socioeconomic status (SES), age and sex. The children self-reported their bed-time, wake-up time and their perceived importance of sleep, among other questions...
May 15, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28502114/risk-factors-for-executive-function-difficulties-in-preschool-and-early-school-age-preterm-children
#12
Sari O'Meagher, Nenagh Kemp, Kimberley Norris, Peter Anderson, Clive Skilbeck
AIM: To investigate the relationship between executive functioning and social and perinatal risk factors in four- to five-year-old preterm children. METHODS: 141 children born preterm (< 33 weeks of gestation) and 77 term comparison children were assessed using standardized measures of general intelligence and performance-based executive function tests prior to starting kindergarten. Parental and teacher reports of executive functioning were completed when the children commenced kindergarten...
May 14, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28498519/starting-enteral-nutrition-with-preterm-single-donor-milk-instead-of-formula-affects-time-to-full-enteral-feeding-in-very-low-birth-weight-infants
#13
Alexandra Kreissl, Elisabeth Sauerzapf, Andreas Repa, Christoph Binder, Margarita Thanhaeuser, Bernd Jilma, Robin Ristl, Angelika Berger, Nadja Haiden
AIM: This study compared the impact of using either single donor breast milk or formula to start enteral feeding in preterm infants, on the time to full enteral feeding, growth and morbidity. The milk was provided by other preterm mothers. METHODS: This was an observational prospective study, carried out from June 2012 - March 2013 at the Medical University of Vienna, Austria, on the effects of preterm single donor milk on 133 very low birth weight infants with a birth weight <1,500g and a gestational age <32 weeks until they were on full enteral feeding...
May 12, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28489289/introducing-high-flow-nasal-cannula-to-the-neonatal-transport-environment
#14
Michael A Boyle, Arunava Dhar, Susan Broster
We are encouraged to see that other neonatal transport services are using High-Flow nasal cannula (HFNC) respiratory support during neonatal transport as outlined by Brunton et al (1). The experiences appear to be broadly similar across the two services, however, due to the central location of the neonatal transport base and the well served road network in the East of England region air transports are not conducted. Despite the increasing numbers of articles relating to HFNC use in neonatal units and consensus statements on best practice there is a relative paucity of data relating to its use on transport (2,3)...
May 10, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28477437/national-epidemiological-study-reveals-longer-paediatric-bone-and-joint-infection-stays-for-infants-and-in-general-hospitals
#15
E Laurent, L Petit, Z Maakaroun-Vermesse, L Bernard, T Odent, L Grammatico-Guillon
AIM: Published studies have suggested that 2-5 days of intravenous treatment could effectively treat paediatric bone and joint infections (PBJI), allowing a faster discharge. This study analysed the factors associated with PBJI hospital stays lasting longer than five days using the French National Hospital Discharge Database. METHODS: We selected children under 15 years hospitalised in 2013 with haematogenous PBJIs using a validated French algorithm based on specific diagnosis and surgical procedure codes...
May 6, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28477430/sound-levels-in-a-neonatal-intensive-care-unit-significantly-exceeded-recommendations-especially-inside-incubators
#16
J Parra, A de Suremain, F Berne Audeoud, A Ego, T Debillon
AIM: This study measured sound levels in a 2008 built French neonatal intensive care unit (NICU) and compared them to the 2007 American Academy of Pediatrics (AAP) recommendations. The ultimate aim was to identify factors that could influence noise levels. METHODS: The study measured sound in 17 single or double rooms in the NICU. Two dosimeters were installed in each room, one inside and one outside the incubators, and these conducted measurements over a 24-hour period...
May 6, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28477429/higher-serum-25-oh-d-concentration-is-associated-with-lower-risk-of-chronic-otitis-media-with-effusion-a-case-control-study
#17
Rebecca E Walker, Jim Bartley, Carlos A Camargo, David Flint, John M D Thompson, Edwin A Mitchell
AIM: Vitamin D supplementation and higher 25(OH)-vitamin D concentration are associated with reduced risk of acute respiratory infection. This study examined whether there is a similar association between higher serum 25(OH)D concentration and lower risk of chronic otitis media with effusion (COME). METHODS: In a case-control study, serum 25(OH)D concentration in children referred for tympanostomy tube placement for COME (n=178) was compared to that of healthy children randomly sampled from primary care practices (n=179)...
May 6, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28477427/tv-or-unrestricted-unmonitored-internet-access-in-the-bedroom-and-bmi-in-youth-athletes
#18
Andrea Stracciolini, Benjamin J Shore, Michael J Pepin, Katherine Eisenberg, William P Meehan
AIM: To correlate television or unrestricted, unmonitored internet access in room of sleep with BMI. METHODS: Cross sectional study of athletes ≤ 19 years who underwent an Injury Prevention Evaluation. Independent variables included proportion of athletes categorized as overweight or obese who answered positively to American Academy of Pediatrics recommended questions: 1) Do you have a TV in the room where you sleep? 2) Do you have unrestricted, unmonitored access to the internet in the room where you sleep?...
May 6, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28477426/optimising-physiology-for-adolescents-with-dysautonomia
#19
Karen Thaxter Nesbeth
I congratulate Armstrong et al (1) on their high quality paper, which will enable us to plan interventions that improve the quality of life of the dysautonomic paediatric population. I support the movement toward programmes that facilitate closely monitored, appropriate exercise regimes, tailored for the dysautonomic adolescent. This may, in the medium to long term be physiologically equivalent to, but more cost-effective than, the intermittent intravenous infusions of saline that have been found to dramatically reduce symptoms and improve the quality of life of patients suffering from postural orthostatic hypotention syndrome (2)...
May 6, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28471526/preterm-infants-at-discharge-nap-polysomnography-versus-24-hour-oximetry
#20
Tamsin Roberts, Angela Campbell, Peter Larsen, Dawn Elder
AIM: This study aimed to determine whether measures of intermittent hypoxia derived from 24-hour oximetry correlate with measures of apnoea derived from modified nap polysomnography undertaken for preterm infants before discharge. METHODS: Infants born ≤32 weeks gestation were recruited from the Neonatal Intensive Care Unit, and had a modified polysomnography to assess their respiratory stability once they were ≥35 weeks postmenstrual age. Infants were defined as unstable if they had more than 10 obstructive events per hour or any apnoea of > 20 seconds in length...
May 4, 2017: Acta Paediatrica
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