Carlo Dani, Marcello Napolitano, Ciro Barone, Angelo Manna, Gabriella Nigro, Gianfranco Scarpelli, Elvira Bonanno, Sara Gatto, Francesco Cavigioli, Carlo Forcellini, Enrico Petoello, Renzo Beghini, Martina Ciarcià, Monica Fusco, Fabio Mosca, Anna Lavizzari, Eloisa Gitto, Letteria Barbuscia, Pasqua Betta, Carmine Mattia, Luigi Corvaglia, Stefania Vedovato, Giovanni Vento, Gianfranco Maffei, Raffaele Falsaperla, Paola Lago, Luca Boni, Gianluca Lista
INTRODUCTION: Approximately half of very preterm infants with respiratory distress syndrome (RDS) fail treatment with nasal continuous positive airway pressure (NCPAP) and need mechanical ventilation (MV). OBJECTIVES: Our aim with this study was to evaluate if nasal intermittent positive pressure ventilation (NIPPV) during less invasive surfactant treatment (LISA) can improve respiratory outcome compared with NCPAP. MATERIALS AND METHODS: We carried out an open-label randomized controlled trial at tertiary neonatal intensive care units in which infants with RDS born at 25+0 -31+6 weeks of gestation between December 1, 2020 and October 31, 2022 were supported with NCPAP before and after surfactant administration and received NIPPV or NCPAP during LISA...
January 22, 2024: Pediatric Pulmonology