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JOURNAL ARTICLE
Amanda I Adler, Ruth L Coleman, Jose Leal, William N Whiteley, Philip Clarke, Rury R Holman
BACKGROUND: The 20-year UK Prospective Diabetes Study showed major clinical benefits for people with newly diagnosed type 2 diabetes randomly allocated to intensive glycaemic control with sulfonylurea or insulin therapy or metformin therapy, compared with conventional glycaemic control. 10-year post-trial follow-up identified enduring and emerging glycaemic and metformin legacy treatment effects. We aimed to determine whether these effects would wane by extending follow-up for another 14 years...
May 17, 2024: Lancet
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JOURNAL ARTICLE
Paul Webster
No abstract text is available yet for this article.
May 17, 2024: Lancet
#3
JOURNAL ARTICLE
Sharmila Devi
No abstract text is available yet for this article.
May 17, 2024: Lancet
#4
JOURNAL ARTICLE
Christopher A Lamb, Cate Titterton, Rupa Banerjee, Anna Gomberg, David T Rubin, Ailsa L Hart
No abstract text is available yet for this article.
May 17, 2024: Lancet
#5
JOURNAL ARTICLE
Shelagh B Coutts, Sandeep Ankolekar, Ramana Appireddy, Juan F Arenillas, Zarina Assis, Peter Bailey, Philip A Barber, Rodrigo Bazan, Brian H Buck, Ken S Butcher, Marie-Christine Camden, Bruce Campbell, Leanne K Casaubon, Luciana Catanese, Kausik Chatterjee, Philip M C Choi, Brian Clarke, Dar Dowlatshahi, Julia Ferrari, Thalia S Field, Aravind Ganesh, Darshan Ghia, Mayank Goyal, Stefan Greisenegger, Omid Halse, Mackenzie Horn, Gary Hunter, Oje Imoukhuede, Peter J Kelly, James Kennedy, Carol Kenney, Timothy J Kleinig, Kailash Krishnan, Fabrico Lima, Jennifer L Mandzia, Martha Marko, Sheila O Martins, George Medvedev, Bijoy K Menon, Sachin M Mishra, Carlos Molina, Aimen Moussaddy, Keith W Muir, Mark W Parsons, Andrew M W Penn, Arthur Pille, Octávio M Pontes-Neto, Christine Roffe, Joaquin Serena, Robert Simister, Nishita Singh, Neil Spratt, Daniel Strbian, Carol H Tham, M Ivan Wiggam, David J Williams, Mark R Willmot, Teddy Wu, Amy Y X Yu, George Zachariah, Atif Zafar, Charlotte Zerna, Michael D Hill
BACKGROUND: Individuals with minor ischaemic stroke and intracranial occlusion are at increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve outcomes in this population. We aimed to test the superiority of intravenous tenecteplase over non-thrombolytic standard of care in patients with minor ischaemic stroke and intracranial occlusion or focal perfusion abnormality. METHODS: In this multicentre, prospective, parallel group, open label with blinded outcome assessment, randomised controlled trial, adult patients (aged ≥18 years) were included at 48 hospitals in Australia, Austria, Brazil, Canada, Finland, Ireland, New Zealand, Singapore, Spain, and the UK...
May 16, 2024: Lancet
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JOURNAL ARTICLE
Simona Sacco, Guillaume Turc
No abstract text is available yet for this article.
May 16, 2024: Lancet
#7
JOURNAL ARTICLE
Chris C Parker, Noel W Clarke, Adrian D Cook, Howard Kynaston, Charles N Catton, William R Cross, Peter M Petersen, Rajendra A Persad, Fred Saad, Lorna C Bower, John Logue, Heather Payne, Silvia Forcat, Cindy Goldstein, Claire Murphy, Juliette Anderson, Maroie Barkati, David M Bottomley, Jennifer Branagan, Ananya Choudhury, Peter W M Chung, Lyn Cogley, Chee L Goh, Peter Hoskin, Vincent Khoo, Shawn C Malone, Lindsey Masters, Stephen L Morris, Abdenour Nabid, Aldrich D Ong, Rakesh Raman, Kathryn L Tarver, Alison C Tree, Jane Worlding, James P Wylie, Anjali M Zarkar, Wendy R Parulekar, Mahesh K B Parmar, Matthew R Sydes
BACKGROUND: Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. METHODS: RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer...
May 16, 2024: Lancet
#8
JOURNAL ARTICLE
Chris C Parker, Howard Kynaston, Adrian D Cook, Noel W Clarke, Charles N Catton, William R Cross, Peter M Petersen, Rajendra A Persad, Cheryl A Pugh, Fred Saad, John Logue, Heather Payne, Lorna C Bower, Chris Brawley, Mary Rauchenberger, Maroie Barkati, David M Bottomley, Klaus Brasso, Hans T Chung, Peter W M Chung, Ruth Conroy, Alison Falconer, Vicky Ford, Chee L Goh, Catherine M Heath, Nicholas D James, Charmaine Kim-Sing, Ravi Kodavatiganti, Shawn C Malone, Stephen L Morris, Abdenour Nabid, Aldrich D Ong, Rakesh Raman, Sree Rodda, Paula Wells, Jane Worlding, Wendy R Parulekar, Mahesh K B Parmar, Matthew R Sydes
BACKGROUND: Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain. METHODS: RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT...
May 16, 2024: Lancet
#9
JOURNAL ARTICLE
Alan Pollack, Alan Dal Pra
No abstract text is available yet for this article.
May 16, 2024: Lancet
#10
LETTER
Muhammad Abu Salmiya
No abstract text is available yet for this article.
May 15, 2024: Lancet
#11
JOURNAL ARTICLE
Jürgen Beck, Christian Fung, Daniel Strbian, Lukas Bütikofer, Werner J Z'Graggen, Matthias F Lang, Seraina Beyeler, Jan Gralla, Florian Ringel, Karl Schaller, Nikolaus Plesnila, Marcel Arnold, Werner Hacke, Peter Jüni, Alexander David Mendelow, Christian Stapf, Rustam Al-Shahi Salman, Jenny Bressan, Stefanie Lerch, Arsany Hakim, Nicolas Martinez-Majander, Anna Piippo-Karjalainen, Peter Vajkoczy, Stefan Wolf, Gerrit A Schubert, Anke Höllig, Michael Veldeman, Roland Roelz, Andreas Gruber, Philip Rauch, Dorothee Mielke, Veit Rohde, Thomas Kerz, Eberhard Uhl, Enea Thanasi, Hagen B Huttner, Bernd Kallmünzer, L Jaap Kappelle, Wolfgang Deinsberger, Christian Roth, Robin Lemmens, Jan Leppert, Jose L Sanmillan, Jonathan M Coutinho, Katharina A M Hackenberg, Gernot Reimann, Mikael Mazighi, Claudio L A Bassetti, Heinrich P Mattle, Andreas Raabe, Urs Fischer
BACKGROUND: It is unknown whether decompressive craniectomy improves clinical outcome for people with spontaneous severe deep intracerebral haemorrhage. The SWITCH trial aimed to assess whether decompressive craniectomy plus best medical treatment in these patients improves outcome at 6 months compared to best medical treatment alone. METHODS: In this multicentre, randomised, open-label, assessor-blinded trial conducted in 42 stroke centres in Austria, Belgium, Finland, France, Germany, the Netherlands, Spain, Sweden, and Switzerland, adults (18-75 years) with a severe intracerebral haemorrhage involving the basal ganglia or thalamus were randomly assigned to receive either decompressive craniectomy plus best medical treatment or best medical treatment alone...
May 14, 2024: Lancet
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JOURNAL ARTICLE
Catharina Jm Klijn, Ruben Dammers, Nikola Sprigg
No abstract text is available yet for this article.
May 14, 2024: Lancet
#13
REVIEW
Nina A Hilkens, Barbara Casolla, Thomas W Leung, Frank-Erik de Leeuw
Stroke affects up to one in five people during their lifetime in some high-income countries, and up to almost one in two in low-income countries. Globally, it is the second leading cause of death. Clinically, the disease is characterised by sudden neurological deficits. Vascular aetiologies contribute to the most common causes of ischaemic stroke, including large artery disease, cardioembolism, and small vessel disease. Small vessel disease is also the most frequent cause of intracerebral haemorrhage, followed by macrovascular causes...
May 14, 2024: Lancet
#14
LETTER
Jessica Smith-Amara
No abstract text is available yet for this article.
May 14, 2024: Lancet
#15
LETTER
Joelle M Abi-Rached, Eric Reinhart
No abstract text is available yet for this article.
May 14, 2024: Lancet
#16
JOURNAL ARTICLE
Doris Kwesiga, Phillip Wanduru
No abstract text is available yet for this article.
May 13, 2024: Lancet
#17
JOURNAL ARTICLE
Ibrahim Abubakar, Rebecca Langella, Nicolas Meda
No abstract text is available yet for this article.
May 13, 2024: Lancet
#18
JOURNAL ARTICLE
Victor Tumukunde, Melissa M Medvedev, Cally J Tann, Ivan Mambule, Catherine Pitt, Charles Opondo, Ayoub Kakande, Ruth Canter, Yiga Haroon, Charity Kirabo-Nagemi, Andrew Abaasa, Wilson Okot, Fredrick Katongole, Raymond Ssenyonga, Natalia Niombi, Carol Nanyunja, Diana Elbourne, Giulia Greco, Elizabeth Ekirapa-Kiracho, Moffat Nyirenda, Elizabeth Allen, Peter Waiswa, Joy E Lawn
BACKGROUND: Preterm birth is the leading cause of death in children younger than 5 years worldwide. WHO recommends kangaroo mother care (KMC); however, its effects on mortality in sub-Saharan Africa and its relative costs remain unclear. We aimed to compare the effectiveness, safety, costs, and cost-effectiveness of KMC initiated before clinical stabilisation versus standard care in neonates weighing up to 2000 g. METHODS: We conducted a parallel-group, individually randomised controlled trial in five hospitals across Uganda...
May 13, 2024: Lancet
#19
JOURNAL ARTICLE
Rebecca L Gould, Christopher J McDermott, Benjamin J Thompson, Charlotte V Rawlinson, Matt Bursnall, Mike Bradburn, Pavithra Kumar, Emily J Turton, David A White, Marc A Serfaty, Christopher D Graham, Lance M McCracken, Laura H Goldstein, Ammar Al-Chalabi, Richard W Orrell, Tim Williams, Rupert Noad, Idris Baker, Christina Faull, Thomas Lambert, Suresh K Chhetri, John Ealing, Anthony Hanratty, Aleksandar Radunovic, Nushan Gunawardana, Gail Meadows, George H Gorrie, Tracey Young, Vanessa Lawrence, Cindy Cooper, Pamela J Shaw, Robert J Howard
BACKGROUND: Motor neuron disease is a progressive, fatal neurodegenerative disease for which there is no cure. Acceptance and Commitment Therapy (ACT) is a psychological therapy incorporating acceptance, mindfulness, and behaviour change techniques. We aimed to evaluate the effectiveness of ACT plus usual care, compared with usual care alone, for improving quality of life in people with motor neuron disease. METHODS: We conducted a parallel, multicentre, two-arm randomised controlled trial in 16 UK motor neuron disease care centres or clinics...
May 9, 2024: Lancet
#20
JOURNAL ARTICLE
Noah Kojima, Cornelia Adlhoch, Oriol Mitja, Vu Quoc Dat, Andres G Lescano, Jeffrey D Klausner
No abstract text is available yet for this article.
May 9, 2024: Lancet
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