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Journals
American Journal of Respirator...
American Journal of Respiratory and Critical Care Medicine
#1
JOURNAL ARTICLE
Merete B Long, Amy Gilmour, Margaret Kehl, David Tabor, Ashley E Keller, Paul Warrener, Vancheswaran Gopalakrishnan, Sanna Rosengren, Megan L Crichton, Eve McIntosh, Yan Hui Giam, Holly R Keir, Wayne Brailsford, Rod Hughes, Maria G Belvisi, Bret R Sellman, Antonio DiGiandomenico, James D Chalmers
RATIONALE AND OBJECTIVES: Pseudomonas aeruginosa infection is associated with worse outcomes in bronchiectasis. Impaired neutrophil antimicrobial responses contribute to bacterial persistence. Gremubamab is a bivalent, bispecific monoclonal antibody targeting Psl exopolysaccharide and the type 3 secretion system component PcrV. This study evaluated the efficacy of gremubamab to enhance killing of P.aeruginosa by neutrophils from bronchiectasis patients and to prevent P.aeruginosa -associated cytotoxicity...
May 16, 2024: American Journal of Respiratory and Critical Care Medicine
#2
JOURNAL ARTICLE
Shigeto Horiuchi, Makoto Hibino, Shunichi Tobe, Kazunari Maeda, Riko Kamada, Shigehiro Watanabe, Tetsuri Kondo
No abstract text is available yet for this article.
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
#3
JOURNAL ARTICLE
Lisa Maier, Wonder P Drake
No abstract text is available yet for this article.
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
#4
JOURNAL ARTICLE
Steven M Kawut, Rui Feng, Susan S Ellenberg, Roham Zamanian, Todd Bull, Murali Chakinala, Stephen C Mathai, Anna Hemnes, Grace Lin, Margaret Doyle, Ruth Andrew, Margaret MacLean, Ioannis Stasinopoulos, Eric Austin, Angela DeMichele, Haochang Shou, Jasleen Minhas, Nianfu Song, Jude Moutchia, Corey E Ventetuolo
RATIONALE: Inhibition of aromatase with anastrozole reduces pulmonary hypertension in experimental models. OBJECTIVES: We aimed to determine whether anastrozole improved six-minute walk distance (6MWD) at six months in pulmonary arterial hypertension (PAH). METHODS: We performed a randomized, double-blind, placebo-controlled Phase II clinical trial of anastrozole in subjects with PAH at seven centers. Eighty-four post-menopausal women and men with PAH were randomized in a 1:1 ratio to receive anastrozole 1 mg or placebo by mouth daily, stratified by sex using permuted blocks of variable sizes...
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
#5
JOURNAL ARTICLE
Sarita R Berigei, Sreyankar Nandy, Satomi Yamamoto, Rebecca A Raphaely, Amalia DeCoursey, Jaeyul Lee, Amita Sharma, Hugh G Auchincloss, Henning Gaissert, Michael Lanuti, Harald C Ott, Uma M Sachdeva, Cameron D Wright, Sophia H Zhao, Robert W Hallowell, Barry S Shea, Ashok Muniappan, Colleen M Keyes, Lida P Hariri
RATIONALE: Idiopathic pulmonary fibrosis (IPF) affects subpleural lung, but is considered to spare small airways. Micro-CT studies demonstrated small airway reduction in end-stage IPF explanted lungs, raising questions about small airway involvement in early-stage disease. Endobronchial optical coherence tomography (EB-OCT) is a volumetric imaging modality that detects microscopic features from subpleural to proximal airways. We use EB-OCT to evaluate small airways in early IPF and control subjects in vivo ...
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
#6
JOURNAL ARTICLE
Diego J Maselli, Alejandro A Diaz
No abstract text is available yet for this article.
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
#7
JOURNAL ARTICLE
Miguel Angel Martinez-Garcia
No abstract text is available yet for this article.
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
#8
JOURNAL ARTICLE
Ghislaine Douflé, Bhushan H Katira
No abstract text is available yet for this article.
May 15, 2024: American Journal of Respiratory and Critical Care Medicine
#9
JOURNAL ARTICLE
Pierre-Régis Burgel, Andrew Bush
No abstract text is available yet for this article.
May 8, 2024: American Journal of Respiratory and Critical Care Medicine
#10
JOURNAL ARTICLE
Avraham Unterman, Amy Y Zhao, Nir Neumark, Jonas C Schupp, Farida Ahangari, Carlos Cosme, Prapti Sharma, Jasper Flint, Yan Stein, Changwan Ryu, Genta Ishikawa, Tomokazu S Sumida, Jose L Gomez, Jose D Herazo-Maya, Charles S Dela Cruz, Erica L Herzog, Naftali Kaminski
RATIONALE: Changes in peripheral blood cell populations have been observed but not detailed at single-cell resolution in idiopathic pulmonary fibrosis (IPF). OBJECTIVES: To provide an atlas of the changes in the peripheral immune system in stable and progressive IPF. METHODS: Peripheral blood mononuclear cells (PBMCs) from IPF patients and controls were profiled using 10x Chromium 5' single-cell RNA sequencing (scRNA-seq). Flow cytometry was used for validation...
May 8, 2024: American Journal of Respiratory and Critical Care Medicine
#11
JOURNAL ARTICLE
Amjad Horani
No abstract text is available yet for this article.
May 8, 2024: American Journal of Respiratory and Critical Care Medicine
#12
JOURNAL ARTICLE
Yonghua Gao, Hollian Richardson, Alison J Dicker, Alun Barton, Elena Kuzmanova, Michal Shteinberg, Lidia Perea, Pieter C Goeminne, Erin Cant, Chandani Hennayake, Jennifer Pollock, Hani Abo Leyah, Hayoung Choi, Eva Polverino, Francesco Blasi, Tobias Welte, Stefano Aliberti, Merete Long, Amelia Shoemark, Oriol Sibila, Jeffrey T J Huang, James D Chalmers
RATIONALE: Bronchiectasis is characterised by acute exacerbations but the biological mechanisms underlying these events is poorly characterised. Objectives To investigate the inflammatory and microbial characteristics of exacerbations of bronchiectasis. METHODS: 120 patients with bronchiectasis were enrolled and presented with acute exacerbations within 12 months. Spontaneous sputum samples were obtained during a period of clinical stability and again at exacerbation prior to receipt of antibiotic treatment...
May 8, 2024: American Journal of Respiratory and Critical Care Medicine
#13
JOURNAL ARTICLE
Kimberly D García-Irizarry, Joseph J Perez-Ortiz, Jesús M Meléndez-Montañez, Wilfredo De Jesús-Rojas
No abstract text is available yet for this article.
May 7, 2024: American Journal of Respiratory and Critical Care Medicine
#14
JOURNAL ARTICLE
Pamela J McShane, Amanda E Brunton, Radmila Choate, Meghan Marmor, Christopher J Richards, George M Solomon, Diego J Maselli, Colin Swenson, Timothy R Aksamit, Mark L Metersky
No abstract text is available yet for this article.
May 7, 2024: American Journal of Respiratory and Critical Care Medicine
#15
JOURNAL ARTICLE
Hugo Clermidy, Salim Si-Mohamed, Cyril Prieur, Claire Merveilleux du Vignaux, Philippe Douek, François Tronc
No abstract text is available yet for this article.
May 7, 2024: American Journal of Respiratory and Critical Care Medicine
#16
JOURNAL ARTICLE
Luis Perez-de-Llano, Ghislaine Scelo, Trung N Tran, Tham T Le, Malin Faregås, Borja G Cosio, Matthew Peters, Paul E Pfeffer, Mona Al-Ahmad, Riyad O Al-Lehebi, Alan Altraja, Celine Bergeron, Leif H Bjermer, Anne S Bjerrum, Lakmini Bulathsinhala, John Busby, Diana J Cano Rosales, Giorgio W Canonica, Victoria A Carter, Jeremy Charriot, George C Christoff, Eve J Denton, Delbert R Dorscheid, Maria J Fernandez Sanchez, João A Fonseca, Peter G Gibson, Celine Y Y Goh, Liam G Heaney, Enrico Heffler, Mark Hew, Takashi Iwanaga, Rohit Katial, Mariko S Koh, Piotr Kuna, Désirée E S Larenas-Linnemann, Lauri Lehtimäki, Bassam Mahboub, Neil Martin, Hisako Matsumoto, Andrew N Menzies-Gow, Nikolaos G Papadopoulos, Todor A Popov, Celeste M Porsbjerg, Pujan Patel, Chin K Rhee, Mohsen Sadatsafavi, Camille Taillé, Carlos A Torres-Duque, Ming-Ju Tsai, Charlotte S Ulrik, John W Upham, Anna von Bülow, Eileen Wang, Michael E Wechsler, David B Price
RATIONALE: There is no consensus on criteria to include in an asthma remission definition in real-life. Factors associated with achieving remission post-biologic-initiation remain poorly understood. OBJECTIVES: To quantify the proportion of adults with severe asthma achieving multi-domain-defined remission post-biologic-initiation and identify pre-biologic characteristics associated with achieving remission which may be used to predict it. METHODS: This was a longitudinal cohort study using data from 23 countries from the International Severe Asthma Registry...
May 3, 2024: American Journal of Respiratory and Critical Care Medicine
#17
JOURNAL ARTICLE
Elie Azoulay, Frédéric Pochard, Laurent Argaud, Nancy Kentish-Barnes
No abstract text is available yet for this article.
May 3, 2024: American Journal of Respiratory and Critical Care Medicine
#18
JOURNAL ARTICLE
Iris G van der Sar, Catharina C Moor, Marlies S Wijsenbeek
No abstract text is available yet for this article.
May 3, 2024: American Journal of Respiratory and Critical Care Medicine
#19
JOURNAL ARTICLE
G Jan Zijlstra
No abstract text is available yet for this article.
May 3, 2024: American Journal of Respiratory and Critical Care Medicine
#20
JOURNAL ARTICLE
Yong Huang, Shwu-Fan Ma, Imre Noth
No abstract text is available yet for this article.
May 3, 2024: American Journal of Respiratory and Critical Care Medicine
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